                         SEQUENCE LISTING

<110>  INSERM
 
<120>  METHOD TO TREAT CANCER

<130>  BIO20363 LOPEZ

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric yeast/mouse SMRAD51

<400>  1

Met Ser Gln Val Gln Glu Gln His Ile Ser Glu Ser Gln Leu Gln Tyr 
1               5                   10                  15      


Gly Asn Gly Ser Leu Met Ser Thr Val Pro Ala Asp Leu Ser Gln Ser 
            20                  25                  30          


Val Val Asp Gly Asn Gly Asn Gly Ser Ser Glu Asp Ile Glu Ala Thr 
        35                  40                  45              


Asn Gly Ala Met Gln Met Gln Leu Glu Ala Ser Ala Asp Thr Ser Val 
    50                  55                  60                  


Glu Glu Glu Ser Phe Gly Pro Gln Pro Ile Ser Arg Leu Glu Gln Cys 
65                  70                  75                  80  


Gly Ile Asn Ala Asn Asp Val Lys Lys Leu Glu Glu Ala Gly Tyr His 
                85                  90                  95      


Thr Val Glu Ala Val Ala Tyr Ala Pro Lys Lys Glu Leu Ile Asn Ile 
            100                 105                 110         


Lys Gly Ile Ser Glu Ala Lys Ala Asp Lys Ile Leu Thr Glu Ala Ala 
        115                 120                 125             


Lys Leu Val Pro Met Gly Phe Thr Thr Ala Thr Glu Phe His Gln Arg 
    130                 135                 140                 


Arg Ser Glu Ile Ile Gln Ile Thr Thr Gly Ser Lys Glu Leu Asp Lys 
145                 150                 155                 160 


Leu Leu Gln Gly Gly Ile Glu Thr Gly Ser Ile Thr Glu Met Phe Gly 
                165                 170                 175     


Glu Phe Arg Thr Gly Lys Thr Gln Ile Cys His Thr Leu Ala Val Thr 
            180                 185                 190         


Cys Gln Leu Pro Ile Asp Arg Gly Gly Gly Glu Gly Lys Ala Met Tyr 
        195                 200                 205             


Ile Asp Thr Glu Gly Thr Phe Arg Pro Glu Arg Leu Leu Ala Val Ala 
    210                 215                 220                 


Glu Arg Tyr Gly Leu Ser Gly Ser Asp Val Leu Asp Asn Val Ala Tyr 
225                 230                 235                 240 


Ala Arg Gly Phe Asn Thr Asp His Gln Thr Gln Leu Leu Tyr Gln Ala 
                245                 250                 255     


Ser Ala Met Met Val Glu Ser Arg Tyr Ala Leu Leu Ile Val Asp Ser 
            260                 265                 270         


Ala Thr Ala Leu Tyr Arg Thr Asp Tyr Ser Gly Arg Gly Glu Leu Ser 
        275                 280                 285             


Ala Arg Gln Met His Leu Ala Arg Phe Leu Arg Met Leu Leu Arg Leu 
    290                 295                 300                 


Ala Asp Glu Phe Gly Val Ala Val Val Ile Thr Asn Gln Val Val Ala 
305                 310                 315                 320 


Gln Val Asp Gly Ala Ala Met Phe Ala Ala Asp Pro Lys Lys Pro Ile 
                325                 330                 335     


Gly Gly Asn Ile Ile Ala His Ala Ser Thr Thr Arg Leu Tyr Leu Arg 
            340                 345                 350         


Lys Gly Arg Gly Glu Thr Arg Ile Cys Lys Ile Tyr Asp Ser Pro Cys 
        355                 360                 365             


Leu Pro Glu Ala Glu Ala Met Phe Ala Ile Asn Ala Asp Gly Val Gly 
    370                 375                 380                 


Asp Ala Lys Asp 
385             


<210>  2
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric yeast/human SMRAD51

<400>  2

Met Ser Gln Val Gln Glu Gln His Ile Ser Glu Ser Gln Leu Gln Tyr 
1               5                   10                  15      


Gly Asn Gly Ser Leu Met Ser Thr Val Pro Ala Asp Leu Ser Gln Ser 
            20                  25                  30          


Val Val Asp Gly Asn Gly Asn Gly Ser Ser Glu Asp Ile Glu Ala Thr 
        35                  40                  45              


Asn Gly Ala Met Gln Met Gln Leu Glu Ala Asn Ala Asp Thr Ser Val 
    50                  55                  60                  


Glu Glu Glu Ser Phe Gly Pro Gln Pro Ile Ser Arg Leu Glu Gln Cys 
65                  70                  75                  80  


Gly Ile Asn Ala Asn Asp Val Lys Lys Leu Glu Glu Ala Gly Tyr His 
                85                  90                  95      


Thr Val Glu Ala Val Ala Tyr Ala Pro Lys Lys Glu Leu Ile Asn Ile 
            100                 105                 110         


Lys Gly Ile Ser Glu Ala Lys Ala Asp Lys Ile Leu Thr Glu Ala Ala 
        115                 120                 125             


Lys Leu Val Pro Met Gly Phe Thr Thr Ala Thr Glu Phe His Gln Arg 
    130                 135                 140                 


Arg Ser Glu Ile Ile Gln Ile Thr Thr Gly Ser Lys Glu Leu Asp Lys 
145                 150                 155                 160 


Leu Leu Gln Gly Gly Ile Glu Thr Gly Ser Ile Thr Glu Met Phe Gly 
                165                 170                 175     


Glu Phe Arg Thr Gly Lys Thr Gln Ile Cys His Thr Leu Ala Val Thr 
            180                 185                 190         


Cys Gln Leu Pro Ile Asp Arg Gly Gly Gly Glu Gly Lys Ala Met Tyr 
        195                 200                 205             


Ile Asp Thr Glu Gly Thr Phe Arg Pro Glu Arg Leu Leu Ala Val Ala 
    210                 215                 220                 


Glu Arg Tyr Gly Leu Ser Gly Ser Asp Val Leu Asp Asn Val Ala Tyr 
225                 230                 235                 240 


Ala Arg Gly Phe Asn Thr Asp His Gln Thr Gln Leu Leu Tyr Gln Ala 
                245                 250                 255     


Ser Ala Met Met Val Glu Ser Arg Tyr Ala Leu Leu Ile Val Asp Ser 
            260                 265                 270         


Ala Thr Ala Leu Tyr Arg Thr Asp Tyr Ser Gly Arg Gly Glu Leu Ser 
        275                 280                 285             


Ala Arg Gln Met His Leu Ala Arg Phe Leu Arg Met Leu Leu Arg Leu 
    290                 295                 300                 


Ala Asp Glu Phe Gly Val Ala Val Val Ile Thr Asn Gln Val Val Ala 
305                 310                 315                 320 


Gln Val Asp Gly Ala Ala Met Phe Ala Ala Asp Pro Lys Lys Pro Ile 
                325                 330                 335     


Gly Gly Asn Ile Ile Ala His Ala Ser Thr Thr Arg Leu Tyr Leu Arg 
            340                 345                 350         


Lys Gly Arg Gly Glu Thr Arg Ile Cys Lys Ile Tyr Asp Ser Pro Cys 
        355                 360                 365             


Leu Pro Glu Ala Glu Ala Met Phe Ala Ile Asn Ala Asp Gly Val Gly 
    370                 375                 380                 


Asp Ala Lys Asp 
385             


<210>  3
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Met Gln Met Gln Leu Glu Ala Asn Ala Asp Thr Ser Val Glu 
1               5                   10                  15      


Glu Glu Ser Phe Gly Pro Gln Pro Ile Ser Arg Leu Glu Gln Cys Gly 
            20                  25                  30          


Ile Asn Ala Asn Asp Val Lys Lys Leu Glu Glu Ala Gly Phe His Thr 
        35                  40                  45              


Val Glu Ala Val Ala Tyr Ala Pro Lys Lys Glu Leu Ile Asn Ile Lys 
    50                  55                  60                  


Gly Ile Ser Glu Ala Lys Ala Asp Lys Ile Leu Ala Glu Ala Ala Lys 
65                  70                  75                  80  


Leu Val Pro Met Gly Phe Thr Thr Ala Thr Glu Phe His Gln Arg Arg 
                85                  90                  95      


Ser Glu Ile Ile Gln Ile Thr Thr Gly Ser Lys Glu Leu Asp Lys Leu 
            100                 105                 110         


Leu Gln Gly Gly Ile Glu Thr Gly Ser Ile Thr Glu Met Phe Gly Glu 
        115                 120                 125             


Phe Arg Thr Gly Ala Thr Gln Ile Cys His Thr Leu Ala Val Thr Cys 
    130                 135                 140                 


Gln Leu Pro Ile Asp Arg Gly Gly Gly Glu Gly Lys Ala Met Tyr Ile 
145                 150                 155                 160 


Asp Thr Glu Gly Thr Phe Arg Pro Glu Arg Leu Leu Ala Val Ala Glu 
                165                 170                 175     


Arg Tyr Gly Leu Ser Gly Ser Asp Val Leu Asp Asn Val Ala Tyr Ala 
            180                 185                 190         


Arg Ala Phe Asn Thr Asp His Gln Thr Gln Leu Leu Tyr Gln Ala Ser 
        195                 200                 205             


Ala Met Met Val Glu Ser Arg Tyr Ala Leu Leu Ile Val Asp Ser Ala 
    210                 215                 220                 


Thr Ala Leu Tyr Arg Thr Asp Tyr Ser Gly Arg Gly Glu Leu Ser Ala 
225                 230                 235                 240 


Arg Gln Met His Leu Ala Arg Phe Leu Arg Met Leu Leu Arg Leu Ala 
                245                 250                 255     


Asp Glu Phe Gly Val Ala Val Val Ile Thr Asn Gln Val Val Ala Gln 
            260                 265                 270         


Val Asp Gly Ala Ala Met Phe Ala Ala Asp Pro Lys Lys Pro Ile Gly 
        275                 280                 285             


Gly Asn Ile Ile Ala His Ala Ser Thr Thr Arg Leu Tyr Leu Arg Lys 
    290                 295                 300                 


Gly Arg Gly Glu Thr Arg Ile Cys Lys Ile Tyr Asp Ser Pro Cys Leu 
305                 310                 315                 320 


Pro Glu Ala Glu Ala Met Phe Ala Ile Asn Ala Asp Gly Val Gly Asp 
                325                 330                 335     


Ala Lys Asp 
            


<210>  4
<211>  339
<212>  PRT
<213>  Mus musculus

<400>  4

Met Ala Met Gln Met Gln Leu Glu Ala Ser Ala Asp Thr Ser Val Glu 
1               5                   10                  15      


Glu Glu Ser Phe Gly Pro Gln Pro Ile Ser Arg Leu Glu Gln Cys Gly 
            20                  25                  30          


Ile Asn Ala Asn Asp Val Lys Lys Leu Glu Glu Ala Gly Tyr His Thr 
        35                  40                  45              


Val Glu Ala Val Ala Tyr Ala Pro Lys Lys Glu Leu Ile Asn Ile Lys 
    50                  55                  60                  


Gly Ile Ser Glu Ala Lys Ala Asp Lys Ile Leu Thr Glu Ala Ala Lys 
65                  70                  75                  80  


Leu Val Pro Met Gly Phe Thr Thr Ala Thr Glu Phe His Gln Arg Arg 
                85                  90                  95      


Ser Glu Ile Ile Gln Ile Thr Thr Gly Ser Lys Glu Leu Asp Lys Leu 
            100                 105                 110         


Leu Gln Gly Gly Ile Glu Thr Gly Ser Ile Thr Glu Met Phe Gly Glu 
        115                 120                 125             


Phe Arg Thr Gly Ala Thr Gln Ile Cys His Thr Leu Ala Val Thr Cys 
    130                 135                 140                 


Gln Leu Pro Ile Asp Arg Gly Gly Gly Glu Gly Lys Ala Met Tyr Ile 
145                 150                 155                 160 


Asp Thr Glu Gly Thr Phe Arg Pro Glu Arg Leu Leu Ala Val Ala Glu 
                165                 170                 175     


Arg Tyr Gly Leu Ser Gly Ser Asp Val Leu Asp Asn Val Ala Tyr Ala 
            180                 185                 190         


Arg Gly Phe Asn Thr Asp His Gln Thr Gln Leu Leu Tyr Gln Ala Ser 
        195                 200                 205             


Ala Met Met Val Glu Ser Arg Tyr Ala Leu Leu Ile Val Asp Ser Ala 
    210                 215                 220                 


Thr Ala Leu Tyr Arg Thr Asp Tyr Ser Gly Arg Gly Glu Leu Ser Ala 
225                 230                 235                 240 


Arg Gln Met His Leu Ala Arg Phe Leu Arg Met Leu Leu Arg Leu Ala 
                245                 250                 255     


Asp Glu Phe Gly Val Ala Val Val Ile Thr Asn Gln Val Val Ala Gln 
            260                 265                 270         


Val Asp Gly Ala Ala Met Phe Ala Ala Asp Pro Lys Lys Pro Ile Gly 
        275                 280                 285             


Gly Asn Ile Ile Ala His Ala Ser Thr Thr Arg Leu Tyr Leu Arg Lys 
    290                 295                 300                 


Gly Arg Gly Glu Thr Arg Ile Cys Lys Ile Tyr Asp Ser Pro Cys Leu 
305                 310                 315                 320 


Pro Glu Ala Glu Ala Met Phe Ala Ile Asn Ala Asp Gly Val Gly Asp 
                325                 330                 335     


Ala Lys Asp 
            


<210>  5
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Met Gln Met Gln Leu Glu Ala Asn Ala Asp Thr Ser Val Glu 
1               5                   10                  15      


Glu Glu Ser Phe Gly Pro Gln Pro Ile Ser Arg Leu Glu Gln Cys Gly 
            20                  25                  30          


Ile Asn Ala Asn Asp Val Lys Lys Leu Glu Glu Ala Gly Phe His Thr 
        35                  40                  45              


Val Glu Ala Val Ala Tyr Ala Pro Lys Lys Glu Leu Ile Asn Ile Lys 
    50                  55                  60                  


Gly Ile Ser Glu Ala Lys Ala Asp Lys Ile Leu Ala Glu Ala Ala Lys 
65                  70                  75                  80  


Leu Val Pro Met Gly Phe Thr Thr Ala Thr Glu Phe His Gln Arg Arg 
                85                  90                  95      


Ser Glu Ile Ile Gln Ile Thr Thr Gly Ser Lys Glu Leu Asp Lys Leu 
            100                 105                 110         


Leu Gln Gly Gly Ile Glu Thr Gly Ser Ile Thr Glu Met Phe Gly Glu 
        115                 120                 125             


Phe Arg Thr Gly Arg Thr Gln Ile Cys His Thr Leu Ala Val Thr Cys 
    130                 135                 140                 


Gln Leu Pro Ile Asp Arg Gly Gly Gly Glu Gly Lys Ala Met Tyr Ile 
145                 150                 155                 160 


Asp Thr Glu Gly Thr Phe Arg Pro Glu Arg Leu Leu Ala Val Ala Glu 
                165                 170                 175     


Arg Tyr Gly Leu Ser Gly Ser Asp Val Leu Asp Asn Val Ala Tyr Ala 
            180                 185                 190         


Arg Ala Phe Asn Thr Asp His Gln Thr Gln Leu Leu Tyr Gln Ala Ser 
        195                 200                 205             


Ala Met Met Val Glu Ser Arg Tyr Ala Leu Leu Ile Val Asp Ser Ala 
    210                 215                 220                 


Thr Ala Leu Tyr Arg Thr Asp Tyr Ser Gly Arg Gly Glu Leu Ser Ala 
225                 230                 235                 240 


Arg Gln Met His Leu Ala Arg Phe Leu Arg Met Leu Leu Arg Leu Ala 
                245                 250                 255     


Asp Glu Phe Gly Val Ala Val Val Ile Thr Asn Gln Val Val Ala Gln 
            260                 265                 270         


Val Asp Gly Ala Ala Met Phe Ala Ala Asp Pro Lys Lys Pro Ile Gly 
        275                 280                 285             


Gly Asn Ile Ile Ala His Ala Ser Thr Thr Arg Leu Tyr Leu Arg Lys 
    290                 295                 300                 


Gly Arg Gly Glu Thr Arg Ile Cys Lys Ile Tyr Asp Ser Pro Cys Leu 
305                 310                 315                 320 


Pro Glu Ala Glu Ala Met Phe Ala Ile Asn Ala Asp Gly Val Gly Asp 
                325                 330                 335     


Ala Lys Asp 
            


<210>  6
<211>  339
<212>  PRT
<213>  Mus musculus

<400>  6

Met Ala Met Gln Met Gln Leu Glu Ala Ser Ala Asp Thr Ser Val Glu 
1               5                   10                  15      


Glu Glu Ser Phe Gly Pro Gln Pro Ile Ser Arg Leu Glu Gln Cys Gly 
            20                  25                  30          


Ile Asn Ala Asn Asp Val Lys Lys Leu Glu Glu Ala Gly Tyr His Thr 
        35                  40                  45              


Val Glu Ala Val Ala Tyr Ala Pro Lys Lys Glu Leu Ile Asn Ile Lys 
    50                  55                  60                  


Gly Ile Ser Glu Ala Lys Ala Asp Lys Ile Leu Thr Glu Ala Ala Lys 
65                  70                  75                  80  


Leu Val Pro Met Gly Phe Thr Thr Ala Thr Glu Phe His Gln Arg Arg 
                85                  90                  95      


Ser Glu Ile Ile Gln Ile Thr Thr Gly Ser Lys Glu Leu Asp Lys Leu 
            100                 105                 110         


Leu Gln Gly Gly Ile Glu Thr Gly Ser Ile Thr Glu Met Phe Gly Glu 
        115                 120                 125             


Phe Arg Thr Gly Arg Thr Gln Ile Cys His Thr Leu Ala Val Thr Cys 
    130                 135                 140                 


Gln Leu Pro Ile Asp Arg Gly Gly Gly Glu Gly Lys Ala Met Tyr Ile 
145                 150                 155                 160 


Asp Thr Glu Gly Thr Phe Arg Pro Glu Arg Leu Leu Ala Val Ala Glu 
                165                 170                 175     


Arg Tyr Gly Leu Ser Gly Ser Asp Val Leu Asp Asn Val Ala Tyr Ala 
            180                 185                 190         


Arg Gly Phe Asn Thr Asp His Gln Thr Gln Leu Leu Tyr Gln Ala Ser 
        195                 200                 205             


Ala Met Met Val Glu Ser Arg Tyr Ala Leu Leu Ile Val Asp Ser Ala 
    210                 215                 220                 


Thr Ala Leu Tyr Arg Thr Asp Tyr Ser Gly Arg Gly Glu Leu Ser Ala 
225                 230                 235                 240 


Arg Gln Met His Leu Ala Arg Phe Leu Arg Met Leu Leu Arg Leu Ala 
                245                 250                 255     


Asp Glu Phe Gly Val Ala Val Val Ile Thr Asn Gln Val Val Ala Gln 
            260                 265                 270         


Val Asp Gly Ala Ala Met Phe Ala Ala Asp Pro Lys Lys Pro Ile Gly 
        275                 280                 285             


Gly Asn Ile Ile Ala His Ala Ser Thr Thr Arg Leu Tyr Leu Arg Lys 
    290                 295                 300                 


Gly Arg Gly Glu Thr Arg Ile Cys Lys Ile Tyr Asp Ser Pro Cys Leu 
305                 310                 315                 320 


Pro Glu Ala Glu Ala Met Phe Ala Ile Asn Ala Asp Gly Val Gly Asp 
                325                 330                 335     


Ala Lys Asp 
            


<210>  7
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Met Gln Met Gln Leu Glu Ala Asn Ala Asp Thr Ser Val Glu 
1               5                   10                  15      


Glu Glu Ser Phe Gly Pro Gln Pro Ile Ser Arg Leu Glu Gln Cys Gly 
            20                  25                  30          


Ile Asn Ala Asn Asp Val Lys Lys Leu Glu Glu Ala Gly Tyr His Thr 
        35                  40                  45              


Val Glu Ala Val Ala Tyr Ala Pro Lys Lys Glu Leu Ile Asn Ile Lys 
    50                  55                  60                  


Gly Ile Ser Glu Ala Lys Ala Asp Lys Ile Leu Thr Glu Ala Ala Lys 
65                  70                  75                  80  


Leu Val Pro Met Gly Phe Thr Thr Ala Thr Glu Phe His Gln Arg Arg 
                85                  90                  95      


Ser Glu Ile Ile Gln Ile Thr Thr Gly Ser Lys Glu Leu Asp Lys Leu 
            100                 105                 110         


Leu Gln Gly Gly Ile Glu Thr Gly Ser Ile Thr Glu Met Phe Gly Glu 
        115                 120                 125             


Phe Arg Pro Gly Lys Thr Gln Ile Cys His Thr Leu Ala Val Thr Cys 
    130                 135                 140                 


Gln Leu Pro Ile Asp Arg Gly Gly Gly Glu Gly Lys Ala Met Tyr Ile 
145                 150                 155                 160 


Asp Thr Glu Gly Thr Phe Arg Pro Glu Arg Leu Leu Ala Val Ala Glu 
                165                 170                 175     


Arg Tyr Gly Leu Ser Gly Ser Asp Val Leu Asp Asn Val Ala Tyr Ala 
            180                 185                 190         


Arg Gly Phe Asn Thr Asp His Gln Thr Gln Leu Leu Tyr Gln Ala Ser 
        195                 200                 205             


Ala Met Met Val Glu Ser Arg Tyr Ala Leu Leu Ile Val Asp Ser Ala 
    210                 215                 220                 


Thr Ala Leu Tyr Arg Thr Asp Tyr Ser Gly Arg Gly Glu Leu Ser Ala 
225                 230                 235                 240 


Arg Gln Met His Leu Ala Arg Phe Leu Arg Met Leu Leu Arg Leu Ala 
                245                 250                 255     


Asp Glu Phe Gly Val Ala Val Val Ile Thr Asn Gln Val Val Ala Gln 
            260                 265                 270         


Val Asp Gly Ala Ala Met Phe Ala Ala Asp Pro Lys Lys Pro Ile Gly 
        275                 280                 285             


Gly Asn Ile Ile Ala His Ala Ser Thr Thr Arg Leu Tyr Leu Arg Lys 
    290                 295                 300                 


Gly Arg Gly Glu Thr Arg Ile Cys Lys Ile Tyr Asp Ser Pro Cys Leu 
305                 310                 315                 320 


Pro Glu Ala Glu Ala Met Phe Ala Ile Asn Ala Asp Gly Val Gly Asp 
                325                 330                 335     


Ala Lys Asp 
            


<210>  8
<211>  339
<212>  PRT
<213>  Mus musculus

<400>  8

Met Ala Met Gln Met Gln Leu Glu Ala Ser Ala Asp Thr Ser Val Glu 
1               5                   10                  15      


Glu Glu Ser Phe Gly Pro Gln Pro Ile Ser Arg Leu Glu Gln Cys Gly 
            20                  25                  30          


Ile Asn Ala Asn Asp Val Lys Lys Leu Glu Glu Ala Gly Tyr His Thr 
        35                  40                  45              


Val Glu Ala Val Ala Tyr Ala Pro Lys Lys Glu Leu Ile Asn Ile Lys 
    50                  55                  60                  


Gly Ile Ser Glu Ala Lys Ala Asp Lys Ile Leu Thr Glu Ala Ala Lys 
65                  70                  75                  80  


Leu Val Pro Met Gly Phe Thr Thr Ala Thr Glu Phe His Gln Arg Arg 
                85                  90                  95      


Ser Glu Ile Ile Gln Ile Thr Thr Gly Ser Lys Glu Leu Asp Lys Leu 
            100                 105                 110         


Leu Gln Gly Gly Ile Glu Thr Gly Ser Ile Thr Glu Met Phe Gly Glu 
        115                 120                 125             


Phe Arg Pro Gly Lys Thr Gln Ile Cys His Thr Leu Ala Val Thr Cys 
    130                 135                 140                 


Gln Leu Pro Ile Asp Arg Gly Gly Gly Glu Gly Lys Ala Met Tyr Ile 
145                 150                 155                 160 


Asp Thr Glu Gly Thr Phe Arg Pro Glu Arg Leu Leu Ala Val Ala Glu 
                165                 170                 175     


Arg Tyr Gly Leu Ser Gly Ser Asp Val Leu Asp Asn Val Ala Tyr Ala 
            180                 185                 190         


Arg Gly Phe Asn Thr Asp His Gln Thr Gln Leu Leu Tyr Gln Ala Ser 
        195                 200                 205             


Ala Met Met Val Glu Ser Arg Tyr Ala Leu Leu Ile Val Asp Ser Ala 
    210                 215                 220                 


Thr Ala Leu Tyr Arg Thr Asp Tyr Ser Gly Arg Gly Glu Leu Ser Ala 
225                 230                 235                 240 


Arg Gln Met His Leu Ala Arg Phe Leu Arg Met Leu Leu Arg Leu Ala 
                245                 250                 255     


Asp Glu Phe Gly Val Ala Val Val Ile Thr Asn Gln Val Val Ala Gln 
            260                 265                 270         


Val Asp Gly Ala Ala Met Phe Ala Ala Asp Pro Lys Lys Pro Ile Gly 
        275                 280                 285             


Gly Asn Ile Ile Ala His Ala Ser Thr Thr Arg Leu Tyr Leu Arg Lys 
    290                 295                 300                 


Gly Arg Gly Glu Thr Arg Ile Cys Lys Ile Tyr Asp Ser Pro Cys Leu 
305                 310                 315                 320 


Pro Glu Ala Glu Ala Met Phe Ala Ile Asn Ala Asp Gly Val Gly Asp 
                325                 330                 335     


Ala Lys Asp 
            


<210>  9
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Met Gln Met Gln Leu Glu Ala Asn Ala Asp Thr Ser Val Glu 
1               5                   10                  15      


Glu Glu Ser Phe Gly Pro Gln Pro Ile Ser Arg Leu Glu Gln Cys Gly 
            20                  25                  30          


Ile Asn Ala Asn Asp Val Lys Lys Leu Glu Glu Ala Gly Tyr His Thr 
        35                  40                  45              


Val Glu Ala Val Ala Tyr Ala Pro Lys Lys Glu Leu Ile Asn Ile Lys 
    50                  55                  60                  


Gly Ile Ser Glu Ala Lys Ala Asp Lys Ile Leu Thr Glu Ala Ala Lys 
65                  70                  75                  80  


Leu Val Pro Met Gly Phe Thr Thr Ala Thr Glu Phe His Gln Arg Arg 
                85                  90                  95      


Ser Glu Ile Ile Gln Ile Thr Thr Gly Ser Lys Glu Leu Asp Lys Leu 
            100                 105                 110         


Leu Gln Gly Gly Ile Glu Thr Gly Ser Ile Thr Glu Met Phe Gly Glu 
        115                 120                 125             


Phe Ala Thr Gly Lys Thr Gln Ile Cys His Thr Leu Ala Val Thr Cys 
    130                 135                 140                 


Gln Leu Pro Ile Asp Arg Gly Gly Gly Glu Gly Lys Ala Met Tyr Ile 
145                 150                 155                 160 


Asp Thr Glu Gly Thr Phe Arg Pro Glu Arg Leu Leu Ala Val Ala Glu 
                165                 170                 175     


Arg Tyr Gly Leu Ser Gly Ser Asp Val Leu Asp Asn Val Ala Tyr Ala 
            180                 185                 190         


Arg Gly Phe Asn Thr Asp His Gln Thr Gln Leu Leu Tyr Gln Ala Ser 
        195                 200                 205             


Ala Met Met Val Glu Ser Arg Tyr Ala Leu Leu Ile Val Asp Ser Ala 
    210                 215                 220                 


Thr Ala Leu Tyr Arg Thr Asp Tyr Ser Gly Arg Gly Glu Leu Ser Ala 
225                 230                 235                 240 


Arg Gln Met His Leu Ala Arg Phe Leu Arg Met Leu Leu Arg Leu Ala 
                245                 250                 255     


Asp Glu Phe Gly Val Ala Val Val Ile Thr Asn Gln Val Val Ala Gln 
            260                 265                 270         


Val Asp Gly Ala Ala Met Phe Ala Ala Asp Pro Lys Lys Pro Ile Gly 
        275                 280                 285             


Gly Asn Ile Ile Ala His Ala Ser Thr Thr Arg Leu Tyr Leu Ala Lys 
    290                 295                 300                 


Gly Arg Gly Glu Thr Arg Ile Cys Ala Ile Tyr Asp Ser Pro Cys Leu 
305                 310                 315                 320 


Pro Glu Ala Glu Ala Met Phe Ala Ile Asn Ala Asp Gly Val Gly Asp 
                325                 330                 335     


Ala Lys Asp 
            


<210>  10
<211>  339
<212>  PRT
<213>  Mus musculus

<400>  10

Met Ala Met Gln Met Gln Leu Glu Ala Ser Ala Asp Thr Ser Val Glu 
1               5                   10                  15      


Glu Glu Ser Phe Gly Pro Gln Pro Ile Ser Arg Leu Glu Gln Cys Gly 
            20                  25                  30          


Ile Asn Ala Asn Asp Val Lys Lys Leu Glu Glu Ala Gly Tyr His Thr 
        35                  40                  45              


Val Glu Ala Val Ala Tyr Ala Pro Lys Lys Glu Leu Ile Asn Ile Lys 
    50                  55                  60                  


Gly Ile Ser Glu Ala Lys Ala Asp Lys Ile Leu Thr Glu Ala Ala Lys 
65                  70                  75                  80  


Leu Val Pro Met Gly Phe Thr Thr Ala Thr Glu Phe His Gln Arg Arg 
                85                  90                  95      


Ser Glu Ile Ile Gln Ile Thr Thr Gly Ser Lys Glu Leu Asp Lys Leu 
            100                 105                 110         


Leu Gln Gly Gly Ile Glu Thr Gly Ser Ile Thr Glu Met Phe Gly Glu 
        115                 120                 125             


Phe Ala Thr Gly Lys Thr Gln Ile Cys His Thr Leu Ala Val Thr Cys 
    130                 135                 140                 


Gln Leu Pro Ile Asp Arg Gly Gly Gly Glu Gly Lys Ala Met Tyr Ile 
145                 150                 155                 160 


Asp Thr Glu Gly Thr Phe Arg Pro Glu Arg Leu Leu Ala Val Ala Glu 
                165                 170                 175     


Arg Tyr Gly Leu Ser Gly Ser Asp Val Leu Asp Asn Val Ala Tyr Ala 
            180                 185                 190         


Arg Gly Phe Asn Thr Asp His Gln Thr Gln Leu Leu Tyr Gln Ala Ser 
        195                 200                 205             


Ala Met Met Val Glu Ser Arg Tyr Ala Leu Leu Ile Val Asp Ser Ala 
    210                 215                 220                 


Thr Ala Leu Tyr Arg Thr Asp Tyr Ser Gly Arg Gly Glu Leu Ser Ala 
225                 230                 235                 240 


Arg Gln Met His Leu Ala Arg Phe Leu Arg Met Leu Leu Arg Leu Ala 
                245                 250                 255     


Asp Glu Phe Gly Val Ala Val Val Ile Thr Asn Gln Val Val Ala Gln 
            260                 265                 270         


Val Asp Gly Ala Ala Met Phe Ala Ala Asp Pro Lys Lys Pro Ile Gly 
        275                 280                 285             


Gly Asn Ile Ile Ala His Ala Ser Thr Thr Arg Leu Tyr Leu Ala Lys 
    290                 295                 300                 


Gly Arg Gly Glu Thr Arg Ile Cys Ala Ile Tyr Asp Ser Pro Cys Leu 
305                 310                 315                 320 


Pro Glu Ala Glu Ala Met Phe Ala Ile Asn Ala Asp Gly Val Gly Asp 
                325                 330                 335     


Ala Lys Asp 
            


<210>  11
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Lys Glu Asp Gln Val Val Ala Glu Glu Pro Gly Phe Gln Asp Glu 
1               5                   10                  15      


Glu Glu Ser Leu Phe Gln Asp Ile Asp Leu Leu Gln Lys His Gly Ile 
            20                  25                  30          


Asn Val Ala Asp Ile Lys Lys Leu Lys Ser Val Gly Ile Cys Thr Ile 
        35                  40                  45              


Lys Gly Ile Gln Met Thr Thr Arg Arg Ala Leu Cys Asn Val Lys Gly 
    50                  55                  60                  


Leu Ser Glu Ala Lys Val Asp Lys Ile Lys Glu Ala Ala Asn Lys Leu 
65                  70                  75                  80  


Ile Glu Pro Gly Phe Leu Thr Ala Phe Glu Tyr Ser Glu Lys Arg Lys 
                85                  90                  95      


Met Val Phe His Ile Thr Thr Gly Ser Gln Glu Phe Asp Lys Leu Leu 
            100                 105                 110         


Gly Gly Gly Ile Glu Ser Met Ala Ile Thr Glu Ala Phe Gly Glu Phe 
        115                 120                 125             


Arg Thr Gly Lys Thr Gln Leu Ser His Thr Leu Cys Val Thr Ala Gln 
    130                 135                 140                 


Leu Pro Gly Ala Gly Gly Tyr Pro Gly Gly Lys Ile Ile Phe Ile Asp 
145                 150                 155                 160 


Thr Glu Asn Thr Phe Arg Pro Asp Arg Leu Arg Asp Ile Ala Asp Arg 
                165                 170                 175     


Phe Asn Val Asp His Asp Ala Val Leu Asp Asn Val Leu Tyr Ala Arg 
            180                 185                 190         


Ala Tyr Thr Ser Glu His Gln Met Glu Leu Leu Asp Tyr Val Ala Ala 
        195                 200                 205             


Lys Phe His Glu Glu Ala Gly Ile Phe Lys Leu Leu Ile Ile Asp Ser 
    210                 215                 220                 


Ile Met Ala Leu Phe Arg Val Asp Phe Ser Gly Arg Gly Glu Leu Ala 
225                 230                 235                 240 


Glu Arg Gln Gln Lys Leu Ala Gln Met Leu Ser Arg Leu Gln Lys Ile 
                245                 250                 255     


Ser Glu Glu Tyr Asn Val Ala Val Phe Val Thr Asn Gln Met Thr Ala 
            260                 265                 270         


Asp Pro Gly Ala Thr Met Thr Phe Gln Ala Asp Pro Lys Lys Pro Ile 
        275                 280                 285             


Gly Gly His Ile Leu Ala His Ala Ser Thr Thr Arg Ile Ser Leu Arg 
    290                 295                 300                 


Lys Gly Arg Gly Glu Leu Arg Ile Ala Lys Ile Tyr Asp Ser Pro Glu 
305                 310                 315                 320 


Met Pro Glu Asn Glu Ala Thr Phe Ala Ile Thr Ala Gly Gly Ile Gly 
                325                 330                 335     


Asp Ala Lys Glu 
            340 


<210>  12
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Lys Glu Asp Gln Val Val Ala Glu Glu Pro Gly Phe Gln Asp Glu 
1               5                   10                  15      


Glu Glu Ser Leu Phe Gln Asp Ile Asp Leu Leu Gln Lys His Gly Ile 
            20                  25                  30          


Asn Val Ala Asp Ile Lys Lys Leu Lys Ser Val Gly Ile Cys Thr Ile 
        35                  40                  45              


Lys Gly Ile Gln Met Thr Thr Arg Arg Ala Leu Cys Asn Val Lys Gly 
    50                  55                  60                  


Leu Ser Glu Ala Lys Val Asp Lys Ile Lys Glu Ala Ala Asn Lys Leu 
65                  70                  75                  80  


Ile Glu Pro Gly Phe Leu Thr Ala Phe Glu Tyr Ser Glu Lys Arg Lys 
                85                  90                  95      


Met Val Phe His Ile Thr Thr Gly Ser Gln Glu Phe Asp Lys Leu Leu 
            100                 105                 110         


Gly Gly Gly Ile Glu Ser Met Ala Ile Thr Glu Ala Phe Gly Glu Phe 
        115                 120                 125             


Arg Thr Gly Lys Thr Gln Leu Ser His Thr Leu Cys Gly Glu His Gln 
    130                 135                 140                 


Met Glu Leu Leu Asp Tyr Val Ala Ala Lys Phe His Glu Glu Ala Gly 
145                 150                 155                 160 


Ile Phe Lys Leu Leu Ile Ile Asp Ser Ile Met Ala Leu Phe Arg Val 
                165                 170                 175     


Asp Phe Ser Gly Arg Gly Glu Leu Ala Glu Arg Gln Gln Lys Leu Ala 
            180                 185                 190         


Gln Met Leu Ser Arg Leu Gln Lys Ile Ser Glu Glu Tyr Asn Val Ala 
        195                 200                 205             


Val Phe Val Thr Asn Gln Met Thr Ala Asp Pro Gly Ala Thr Met Thr 
    210                 215                 220                 


Phe Gln Ala Asp Pro Lys Lys Pro Ile Gly Gly His Ile Leu Ala His 
225                 230                 235                 240 


Ala Ser Thr Thr Arg Ile Ser Leu Arg Lys Gly Arg Gly Glu Leu Arg 
                245                 250                 255     


Ile Ala Lys Ile Tyr Asp Ser Pro Glu Met Pro Glu Asn Glu Ala Thr 
            260                 265                 270         


Phe Ala Ile Thr Ala Gly Gly Ile Gly Asp Ala Lys Glu 
        275                 280                 285 


<210>  13
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Met Gln Met Gln Leu Glu Ala Ser Ala Asp Thr Ser Val Glu 
1               5                   10                  15      


Glu Glu Ser Phe Gly Pro Gln Pro Ile Ser Arg Leu Glu Gln Cys Gly 
            20                  25                  30          


Ile Asn Ala Asn Asp Val Lys Lys Leu Glu Glu Ala Gly Tyr His Thr 
        35                  40                  45              


Val Glu Ala Val Ala Tyr Ala Pro Lys Lys Glu Leu Ile Asn Ile Lys 
    50                  55                  60                  


Gly Ile Ser Glu Ala Lys Ala Asp Lys Ile Leu Thr Glu Ala Ala Lys 
65                  70                  75                  80  


Leu Val Pro Met Gly Phe Thr Thr Ala Thr Glu Phe His Gln Arg Arg 
                85                  90                  95      


Ser Glu Ile Ile Gln Ile Thr Thr Gly Ser Lys Glu Leu Asp Lys Leu 
            100                 105                 110         


Leu Gln Gly Gly Ile Glu Thr Gly Ser Ile Thr Glu Met Phe Gly Glu 
        115                 120                 125             


Phe Arg Thr Gly Lys Thr Gln Ile Cys His Thr Leu Ala Val Thr Cys 
    130                 135                 140                 


Gln Leu Pro Ile Asp Arg Gly Gly Gly Glu Gly Lys Ala Met Tyr Ile 
145                 150                 155                 160 


Asp Thr Glu Gly Thr Phe Arg Pro Glu Arg Leu Leu Ala Val Ala Glu 
                165                 170                 175     


Arg Tyr Gly Leu Ser Gly Ser Asp Val Leu Asp Asn Val Ala Tyr Ala 
            180                 185                 190         


Arg Gly Phe Asn Thr Asp His Gln Thr Gln Leu Leu Tyr Gln Ala Ser 
        195                 200                 205             


Ala Met Met Val Glu Ser Arg Tyr Ala Leu Leu Ile Val Asp Ser Ala 
    210                 215                 220                 


Thr Ala Leu Tyr Arg Thr Asp Tyr Ser Gly Arg Gly Glu Leu Ser Ala 
225                 230                 235                 240 


Arg Gln Met His Leu Ala Arg Phe Leu Arg Met Leu Leu Arg Leu Ala 
                245                 250                 255     


Asp Glu Phe Gly Val Ala Val Val Ile Thr Asn Gln Val Val Ala Gln 
            260                 265                 270         


Val Asp Gly Ala Ala Met Phe Ala Ala Asp Pro Lys Lys Pro Ile Gly 
        275                 280                 285             


Gly Asn Ile Ile Ala His Ala Ser Thr Thr Arg Leu Tyr Leu Arg Lys 
    290                 295                 300                 


Gly Arg Gly Glu Thr Arg Ile Cys Lys Ile Tyr Asp Ser Pro Cys Leu 
305                 310                 315                 320 


Pro Glu Ala Glu Ala Met Phe Ala Ile Asn Ala Asp Gly Val Gly Asp 
                325                 330                 335     


Ala Lys Asp 
            


<210>  14
<211>  339
<212>  PRT
<213>  Mus musculus

<400>  14

Met Ala Met Gln Met Gln Leu Glu Ala Ser Ala Asp Thr Ser Val Glu 
1               5                   10                  15      


Glu Glu Ser Phe Gly Pro Gln Pro Ile Ser Arg Leu Glu Gln Cys Gly 
            20                  25                  30          


Ile Asn Ala Asn Asp Val Lys Lys Leu Glu Glu Ala Gly Tyr His Thr 
        35                  40                  45              


Val Glu Ala Val Ala Tyr Ala Pro Lys Lys Glu Leu Ile Asn Ile Lys 
    50                  55                  60                  


Gly Ile Ser Glu Ala Lys Ala Asp Lys Ile Leu Thr Glu Ala Ala Lys 
65                  70                  75                  80  


Leu Val Pro Met Gly Phe Thr Thr Ala Thr Glu Phe His Gln Arg Arg 
                85                  90                  95      


Ser Glu Ile Ile Gln Ile Thr Thr Gly Ser Lys Glu Leu Asp Lys Leu 
            100                 105                 110         


Leu Gln Gly Gly Ile Glu Thr Gly Ser Ile Thr Glu Met Phe Gly Glu 
        115                 120                 125             


Phe Arg Thr Gly Lys Thr Gln Ile Cys His Thr Leu Ala Val Thr Cys 
    130                 135                 140                 


Gln Leu Pro Ile Asp Arg Gly Gly Gly Glu Gly Lys Ala Met Tyr Ile 
145                 150                 155                 160 


Asp Thr Glu Gly Thr Phe Arg Pro Glu Arg Leu Leu Ala Val Ala Glu 
                165                 170                 175     


Arg Tyr Gly Leu Ser Gly Ser Asp Val Leu Asp Asn Val Ala Tyr Ala 
            180                 185                 190         


Arg Gly Phe Asn Thr Asp His Gln Thr Gln Leu Leu Tyr Gln Ala Ser 
        195                 200                 205             


Ala Met Met Val Glu Ser Arg Tyr Ala Leu Leu Ile Val Asp Ser Ala 
    210                 215                 220                 


Thr Ala Leu Tyr Arg Thr Asp Tyr Ser Gly Arg Gly Glu Leu Ser Ala 
225                 230                 235                 240 


Arg Gln Met His Leu Ala Arg Phe Leu Arg Met Leu Leu Arg Leu Ala 
                245                 250                 255     


Asp Glu Phe Gly Val Ala Val Val Ile Thr Asn Gln Val Val Ala Gln 
            260                 265                 270         


Val Asp Gly Ala Ala Met Phe Ala Ala Asp Pro Lys Lys Pro Ile Gly 
        275                 280                 285             


Gly Asn Ile Ile Ala His Ala Ser Thr Thr Arg Leu Tyr Leu Arg Lys 
    290                 295                 300                 


Gly Arg Gly Glu Thr Arg Ile Cys Lys Ile Tyr Asp Ser Pro Cys Leu 
305                 310                 315                 320 


Pro Glu Ala Glu Ala Met Phe Ala Ile Asn Ala Asp Gly Val Gly Asp 
                325                 330                 335     


Ala Lys Asp 
            


<210>  15
<211>  1167
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric yeast/mouse SMRAD51

<400>  15
atgtctcaag ttcaagaaca acatatatca gagtcacagc ttcagtacgg gaacggttcg       60

ttgatgtcca ctgtaccagc agacctttca cagtcagtcg ttgatggaaa cggcaacggt      120

agcagcgaag atattgaggc caccaacggc gctatgcaaa tgcagcttga agcaagtgca      180

gatacttcag tggaagaaga aagttttggt ccacagccta tttcacggtt agagcagtgt      240

ggcataaatg ccaatgatgt gaagaaatta gaagaagccg gttaccatac agtggaggct      300

gttgcttatg caccgaagaa ggaactaata aatattaagg gaattagtga agccaaagct      360

gacaaaattc tgactgaggc agcaaaattg gttccaatgg gtttcaccac ggcaactgag      420

tttcaccagc gccggtcaga gatcatacag ataactactg gctccaaaga gctggacaag      480

ctgcttcaag gtggaattga gactggatct atcacagaga tgtttggaga attccgaact      540

gggaagacac agatctgtca tacgttggct gttacatgcc agctccccat tgaccgtggt      600

ggaggtgaag ggaaggccat gtacattgac accgagggca cctttaggcc ggagcggctg      660

ctagcagtag ctgagagata cggtctctct ggcagcgatg tcctagataa tgtagcatat      720

gcgcgagggt tcaacacaga ccaccagacc cagctccttt accaagcgtc agccatgatg      780

gtagaatcca ggtatgcact gcttattgta gacagtgcta ctgcccttta cagaacagac      840

tactcagggc ggggagagct ttcagccagg caaatgcatt tggccagatt tctgaggatg      900

ctgcttcgac ttgctgatga gtttggtgtc gcagtggtaa tcaccaacca ggtagtagcc      960

caagtagatg gagcagccat gttcgctgca gatcccaaaa aacccattgg agggaacatc     1020

atcgctcatg cgtcaaccac caggctgtac ctgagaaaag gaagagggga gaccagaatc     1080

tgcaaaatct atgactctcc ctgtcttcct gaagctgaag ctatgtttgc cattaatgca     1140

gatggagtgg gcgatgccaa agactga                                         1167


<210>  16
<211>  1167
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric yeast/human SMRAD51

<400>  16
atgtctcaag ttcaagaaca acatatatca gagtcacagc ttcagtacgg gaacggttcg       60

ttgatgtcca ctgtaccagc agacctttca cagtcagtcg ttgatggaaa cggcaacggt      120

agcagcgaag atattgaggc caccaacggc gcaatgcaga tgcagcttga agcaaatgca      180

gatacttcag tggaagaaga aagctttggc ccacaaccca tttcacggtt agagcagtgt      240

ggcataaatg ccaacgatgt gaagaaattg gaagaagctg gattccatac tgtggaggct      300

gttgcctatg cgccaaagaa ggagctaata aatattaagg gaattagtga agccaaagct      360

gataaaattc tggctgaggc agctaaatta gttccaatgg gtttcaccac tgcaactgaa      420

ttccaccaaa ggcggtcaga gatcatacag attactactg gctccaaaga gcttgacaaa      480

ctacttcaag gtggaattga gactggatct atcacagaaa tgtttggaga attccgaact      540

gggaagaccc agatctgtca tacgctagct gtcacctgcc agcttcccat tgaccggggt      600

ggaggtgaag gaaaggccat gtacattgac actgagggta cctttaggcc agaacggctg      660

ctggcagtgg ctgagaggta tggtctctct ggcagtgatg tcctggataa tgtagcatat      720

gctcgagcgt tcaacacaga ccaccagacc cagctccttt atcaagcatc agccatgatg      780

gtagaatcta ggtatgcact gcttattgta gacagtgcca ccgcccttta cagaacagac      840

tactcgggtc gaggtgagct ttcagccagg cagatgcact tggccaggtt tctgcggatg      900

cttctgcgac tcgctgatga gtttggtgta gcagtggtaa tcactaatca ggtggtagct      960

caagtggatg gagcagcgat gtttgctgct gatcccaaaa aacctattgg aggaaatatc     1020

atcgcccatg catcaacaac cagattgtat ctgaggaaag gaagagggga aaccagaatc     1080

tgcaaaatct acgactctcc ctgtcttcct gaagctgaag ctatgttcgc cattaatgca     1140

gatggagtgg gagatgccaa agactga                                         1167


<210>  17
<211>  1023
<212>  DNA
<213>  Homo sapiens

<400>  17
atgaaggagg atcaagttgt ggcggaagaa ccaggattcc aagatgaaga ggaatctttg       60

tttcaagata ttgacctgtt acagaaacat ggaattaacg tggctgacat taagaaactg      120

aaatcagtag gaatctgtac catcaaaggt atacagatga caacaagaag agctctatgc      180

aatgtcaaag gactctcaga agccaaagta gacaagatta aagaggcagc gaacaaacta      240

attgaaccag gattcttgac tgcatttgag tatagtgaaa agaggaaaat ggttttccat      300

atcaccaccg ggagccagga atttgataag ttactaggag gtggaattga aagtatggca      360

attacagaag cttttggaga atttcgtact ggaaaaaccc agctttctca taccctctgt      420

gtgacagctc aacttccagg agctggtggc tacccaggag gaaagattat cttcattgat      480

acagaaaata ctttccgtcc agatcgcctt agggacattg ctgatcgctt taatgtagac      540

catgatgcag tactggacaa cgtactttat gcacgtgcat atactagtga acatcagatg      600

gagctacttg attatgtagc agcaaagttc catgaagaag ctggcatctt caagctattg      660

attatcgatt caataatggc actttttcga gtggatttca gtggccgtgg ggagttggcc      720

gaacggcagc aaaaattggc ccagatgttg tcacgactcc aaaaaatctc agaagaatat      780

aacgtggctg tttttgtgac caatcaaatg actgccgatc caggagcaac tatgaccttt      840

caggcagatc ccaaaaaacc cattggggga cacattctgg ctcatgcttc aacaacaaga      900

ataagcttgc gaaagggaag aggagagctc agaattgcca agatttatga cagtcctgag      960

atgcctgaaa atgaagccac cttcgcaata actgctggag gaattgggga tgccaaggag     1020

tag                                                                   1023


<210>  18
<211>  858
<212>  DNA
<213>  Homo sapiens

<400>  18
atgaaggagg atcaagttgt ggcggaagaa ccaggattcc aagatgaaga ggaatctttg       60

tttcaagata ttgacctgtt acagaaacat ggaattaacg tggctgacat taagaaactg      120

aaatcagtag gaatctgtac catcaaaggt atacagatga caacaagaag agctctatgc      180

aatgtcaaag gactctcaga agccaaagta gacaagatta aagaggcagc gaacaaacta      240

attgaaccag gattcttgac tgcatttgag tatagtgaaa agaggaaaat ggttttccat      300

atcaccaccg ggagccagga atttgataag ttactaggag gtggaattga aagtatggca      360

attacagaag cttttggaga atttcgtact ggaaaaaccc agctttctca taccctctgt      420

ggtgaacatc agatggagct acttgattat gtagcagcaa agttccatga agaagctggc      480

atcttcaagc tattgattat cgattcaata atggcacttt ttcgagtgga tttcagtggc      540

cgtggggagt tggccgaacg gcagcaaaaa ttggcccaga tgttgtcacg actccaaaaa      600

atctcagaag aatataacgt ggctgttttt gtgaccaatc aaatgactgc cgatccagga      660

gcaactatga cctttcaggc agatcccaaa aaacccattg ggggacacat tctggctcat      720

gcttcaacaa caagaataag cttgcgaaag ggaagaggag agctcagaat tgccaagatt      780

tatgacagtc ctgagatgcc tgaaaatgaa gccaccttcg caataactgc tggaggaatt      840

ggggatgcca aggagtag                                                    858


<210>  19
<211>  1020
<212>  DNA
<213>  Homo sapiens

<400>  19
atggcaatgc agatgcagct tgaagcaaat gcagatactt cagtggaaga agaaagcttt       60

ggcccacaac ccatttcacg gttagagcag tgtggcataa atgccaacga tgtgaagaaa      120

ttggaagaag ctggattcca tactgtggag gctgttgcct atgcgccaaa gaaggagcta      180

ataaatatta agggaattag tgaagccaaa gctgataaaa ttctggctga ggcagctaaa      240

ttagttccaa tgggtttcac cactgcaact gaattccacc aaaggcggtc agagatcata      300

cagattacta ctggctccaa agagcttgac aaactacttc aaggtggaat tgagactgga      360

tctatcacag aaatgtttgg agaattccga actgggaaga cccagatctg tcatacgcta      420

gctgtcacct gccagcttcc cattgaccgg ggtggaggtg aaggaaaggc catgtacatt      480

gacactgagg gtacctttag gccagaacgg ctgctggcag tggctgagag gtatggtctc      540

tctggcagtg atgtcctgga taatgtagca tatgctcgag cgttcaacac agaccaccag      600

acccagctcc tttatcaagc atcagccatg atggtagaat ctaggtatgc actgcttatt      660

gtagacagtg ccaccgccct ttacagaaca gactactcgg gtcgaggtga gctttcagcc      720

aggcagatgc acttggccag gtttctgcgg atgcttctgc gactcgctga tgagtttggt      780

gtagcagtgg taatcactaa tcaggtggta gctcaagtgg atggagcagc gatgtttgct      840

gctgatccca aaaaacctat tggaggaaat atcatcgccc atgcatcaac aaccagattg      900

tatctgagga aaggaagagg ggaaaccaga atctgcaaaa tctacgactc tccctgtctt      960

cctgaagctg aagctatgtt cgccattaat gcagatggag tgggagatgc caaagactga     1020


<210>  20
<211>  1020
<212>  DNA
<213>  Mus musculus

<400>  20
atggctatgc aaatgcagct tgaagcaagt gcagatactt cagtggaaga agaaagtttt       60

ggtccacagc ctatttcacg gttagagcag tgtggcataa atgccaatga tgtgaagaaa      120

ttagaagaag ccggttacca tacagtggag gctgttgctt atgcaccgaa gaaggaacta      180

ataaatatta agggaattag tgaagccaaa gctgacaaaa ttctgactga ggcagcaaaa      240

ttggttccaa tgggtttcac cacggcaact gagtttcacc agcgccggtc agagatcata      300

cagataacta ctggctccaa agagctggac aagctgcttc aaggtggaat tgagactgga      360

tctatcacag agatgtttgg agaattccga actgggaaga cacagatctg tcatacgttg      420

gctgttacat gccagctccc cattgaccgt ggtggaggtg aagggaaggc catgtacatt      480

gacaccgagg gcacctttag gccggagcgg ctgctagcag tagctgagag atacggtctc      540

tctggcagcg atgtcctaga taatgtagca tatgcgcgag ggttcaacac agaccaccag      600

acccagctcc tttaccaagc gtcagccatg atggtagaat ccaggtatgc actgcttatt      660

gtagacagtg ctactgccct ttacagaaca gactactcag ggcggggaga gctttcagcc      720

aggcaaatgc atttggccag atttctgagg atgctgcttc gacttgctga tgagtttggt      780

gtcgcagtgg taatcaccaa ccaggtagta gcccaagtag atggagcagc catgttcgct      840

gcagatccca aaaaacccat tggagggaac atcatcgctc atgcgtcaac caccaggctg      900

tacctgagaa aaggaagagg ggagaccaga atctgcaaaa tctatgactc tccctgtctt      960

cctgaagctg aagctatgtt tgccattaat gcagatggag tgggcgatgc caaagactga     1020


