                         SEQUENCE LISTING

<110>  BerGenBio ASA
 
<120>  COMBINATION THERAPY

<130>  008177164

<150>  GB2104037.3
<151>  2021-03-23

<160>  248   

<170>  PatentIn version 3.5

<210>  1
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGB149 VH

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Asp Phe 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Phe Pro Gly Gly Asp Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Ala Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  2
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGB149 VL

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Ile Pro Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Gln Gly 
                85                  90                  95      


Thr His Val Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  3
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGB149 HCDR1 chothia definition

<400>  3

Gly Tyr Ser Phe Thr Asp Phe 
1               5           


<210>  4
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGB149 HCDR2 chothia definition

<400>  4

Phe Pro Gly Gly Asp Asn 
1               5       


<210>  5
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGB149 HCDR3 chothia definition

<400>  5

Arg Gly Leu Tyr Tyr Ala Met Asp Tyr 
1               5                   


<210>  6
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGB149 LCDR1 chothia definition

<400>  6

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Ile Pro Tyr Leu His 
1               5                   10                  15      


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGB149 LCDR2 chothia definition

<400>  7

Arg Val Ser Asn Arg Phe Ser 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGB149 LCDR3 chothia definition

<400>  8

Ser Gln Gly Thr His Val Pro Pro Thr 
1               5                   


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGB149 HCDR1 AbM definition

<400>  9

Gly Tyr Ser Phe Thr Asp Phe Tyr Ile Asn 
1               5                   10  


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGB149 HCDR2 AbM definition

<400>  10

Arg Ile Phe Pro Gly Gly Asp Asn Thr Tyr 
1               5                   10  


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGB149 HCDR3 AbM definition

<400>  11

Arg Gly Leu Tyr Tyr Ala Met Asp Tyr 
1               5                   


<210>  12
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGB149 LCDR1 AbM definition

<400>  12

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Ile Pro Tyr Leu His 
1               5                   10                  15      


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGB149 LCDR2 AbM definition

<400>  13

Arg Val Ser Asn Arg Phe Ser 
1               5           


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGB149 LCDR3 AbM definition

<400>  14

Ser Gln Gly Thr His Val Pro Pro Thr 
1               5                   


<210>  15
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGB149 HCDR1 Kabat definition

<400>  15

Asp Phe Tyr Ile Asn 
1               5   


<210>  16
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGB149 HCDR2 Kabat definition

<400>  16

Arg Ile Phe Pro Gly Gly Asp Asn Thr Tyr Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGB149 HCDR3 Kabat definition

<400>  17

Arg Gly Leu Tyr Tyr Ala Met Asp Tyr 
1               5                   


<210>  18
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGB149 LCDR1 Kabat definition

<400>  18

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Ile Pro Tyr Leu His 
1               5                   10                  15      


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGB149 LCDR2 Kabat definition

<400>  19

Arg Val Ser Asn Arg Phe Ser 
1               5           


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGB149 LCDR3 Kabat definition

<400>  20

Ser Gln Gly Thr His Val Pro Pro Thr 
1               5                   


<210>  21
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGB149 HCDR1 contact definition

<400>  21

Thr Asp Phe Tyr Ile Asn 
1               5       


<210>  22
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGB149 HCDR2 contact definition

<400>  22

Trp Val Ala Arg Ile Phe Pro Gly Gly Asp Asn Thr Tyr 
1               5                   10              


<210>  23
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGB149 HCDR3 contact definition

<400>  23

Ala Arg Arg Gly Leu Tyr Tyr Ala Met Asp 
1               5                   10  


<210>  24
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGB149 LCDR1 contact definition

<400>  24

Val His Ser Asn Gly Ile Pro Tyr Leu His Trp Tyr 
1               5                   10          


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGB149 LCDR2 contact definition

<400>  25

Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe 
1               5                   10  


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGB149 LCDR3 contact definition

<400>  26

Ser Gln Gly Thr His Val Pro Pro 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGB149 HCDR1 IMGT definition

<400>  27

Gly Tyr Ser Phe Thr Asp Phe Tyr 
1               5               


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGB149 HCDR2 IMGT definition

<400>  28

Ile Phe Pro Gly Gly Asp Asn Thr 
1               5               


<210>  29
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGB149 HCDR3 IMGT definition

<400>  29

Ala Arg Arg Gly Leu Tyr Tyr Ala Met Asp Tyr 
1               5                   10      


<210>  30
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGB149 LCDR1 IMGT definition

<400>  30

Gln Ser Leu Val His Ser Asn Gly Ile Pro Tyr 
1               5                   10      


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGB149 LCDR3 IMGT definition

<400>  31

Ser Gln Gly Thr His Val Pro Pro Thr 
1               5                   


<210>  32
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5alt VH

<400>  32

Glu Val Gln Leu Val Gln Ser Gly Ala Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Asp Phe 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Arg Ile Phe Pro Gly Gly Asp Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Ala Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  33
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5alt VL

<400>  33

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Ile Pro Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Gln Gly 
                85                  90                  95      


Thr His Val Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5alt HCDR1 chothia definition

<400>  34

Gly Tyr Ser Phe Thr Asp Phe 
1               5           


<210>  35
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5alt HCDR2 chothia definition

<400>  35

Phe Pro Gly Gly Asp Asn 
1               5       


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5alt HCDR3 chothia definition

<400>  36

Arg Gly Leu Tyr Tyr Ala Met Asp Tyr 
1               5                   


<210>  37
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5alt LCDR1 chothia definition

<400>  37

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Ile Pro Tyr Leu His 
1               5                   10                  15      


<210>  38
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5alt LCDR2 chothia definition

<400>  38

Arg Val Ser Asn Arg Phe Ser 
1               5           


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5alt LCDR3 chothia definition

<400>  39

Ser Gln Gly Thr His Val Pro Pro Thr 
1               5                   


<210>  40
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5alt HCDR1 AbM definition

<400>  40

Gly Tyr Ser Phe Thr Asp Phe Tyr Ile Asn 
1               5                   10  


<210>  41
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5alt HCDR2 AbM definition

<400>  41

Arg Ile Phe Pro Gly Gly Asp Asn Thr Tyr 
1               5                   10  


<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5alt HCDR3 AbM definition

<400>  42

Arg Gly Leu Tyr Tyr Ala Met Asp Tyr 
1               5                   


<210>  43
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5alt LCDR1 AbM definition

<400>  43

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Ile Pro Tyr Leu His 
1               5                   10                  15      


<210>  44
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5alt LCDR2 AbM definition

<400>  44

Arg Val Ser Asn Arg Phe Ser 
1               5           


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5alt LCDR3 AbM definition

<400>  45

Ser Gln Gly Thr His Val Pro Pro Thr 
1               5                   


<210>  46
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5alt HCDR1 Kabat definition

<400>  46

Asp Phe Tyr Ile Asn 
1               5   


<210>  47
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5alt HCDR2 Kabat definition

<400>  47

Arg Ile Phe Pro Gly Gly Asp Asn Thr Tyr Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5alt HCDR3 Kabat definition

<400>  48

Arg Gly Leu Tyr Tyr Ala Met Asp Tyr 
1               5                   


<210>  49
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5alt LCDR1 Kabat definition

<400>  49

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Ile Pro Tyr Leu His 
1               5                   10                  15      


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5alt LCDR2 Kabat definition

<400>  50

Arg Val Ser Asn Arg Phe Ser 
1               5           


<210>  51
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5alt LCDR3 Kabat definition

<400>  51

Ser Gln Gly Thr His Val Pro Pro Thr 
1               5                   


<210>  52
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5alt HCDR1 Contact definition

<400>  52

Thr Asp Phe Tyr Ile Asn 
1               5       


<210>  53
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5alt HCDR2 Contact definition

<400>  53

Trp Ile Ala Arg Ile Phe Pro Gly Gly Asp Asn Thr Tyr 
1               5                   10              


<210>  54
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5alt HCDR3 Contact definition

<400>  54

Ala Arg Arg Gly Leu Tyr Tyr Ala Met Asp 
1               5                   10  


<210>  55
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5alt LCDR1 Contact definition

<400>  55

Val His Ser Asn Gly Ile Pro Tyr Leu His Trp Tyr 
1               5                   10          


<210>  56
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5alt LCDR2 Contact definition

<400>  56

Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe 
1               5                   10  


<210>  57
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5alt LCDR3 Contact definition

<400>  57

Ser Gln Gly Thr His Val Pro Pro 
1               5               


<210>  58
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5alt HCDR1 IMGT definition

<400>  58

Gly Tyr Ser Phe Thr Asp Phe Tyr 
1               5               


<210>  59
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5alt HCDR2 IMGT definition

<400>  59

Ile Phe Pro Gly Gly Asp Asn Thr 
1               5               


<210>  60
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5alt HCDR3 IMGT definition

<400>  60

Ala Arg Arg Gly Leu Tyr Tyr Ala Met Asp Tyr 
1               5                   10      


<210>  61
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5alt LCDR1 IMGT definition

<400>  61

Gln Ser Leu Val His Ser Asn Gly Ile Pro Tyr 
1               5                   10      


<210>  62
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5alt LCDR3 IMGT definition

<400>  62

Ser Gln Gly Thr His Val Pro Pro Thr 
1               5                   


<210>  63
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m10C9 VH

<400>  63

Gln Val Gln Leu Gln Gln Pro Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Asp Tyr Asn Phe Thr Arg Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Thr Gly Asp Ser Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Gln Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asn Gly Asn Tyr Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr 
            100                 105                 110         


Ala Val Thr Val Ser Ser 
        115             


<210>  64
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m10C9 VL

<400>  64

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Gly Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Arg Glu Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  65
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m10C9 HCDR1 Chothia definition

<400>  65

Asp Tyr Asn Phe Thr Arg Tyr 
1               5           


<210>  66
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m10C9 HCDR2 Chothia definition

<400>  66

Tyr Pro Gly Thr Gly Asp 
1               5       


<210>  67
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m10C9 HCDR3 Chothia definition

<400>  67

Asn Gly Asn Tyr Trp Tyr Phe Asp Val 
1               5                   


<210>  68
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m10C9 LCDR1 Chothia definition

<400>  68

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  69
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m10C9 LCDR2  Chothia definition

<400>  69

Arg Met Ser Asn Leu Ala Ser 
1               5           


<210>  70
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m10C9 LCDR3 Chothia definition

<400>  70

Met Gln His Arg Glu Tyr Pro Phe Thr 
1               5                   


<210>  71
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m10C9 HCDR1 AbM definition

<400>  71

Asp Tyr Asn Phe Thr Arg Tyr Tyr Ile His 
1               5                   10  


<210>  72
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m10C9 HCDR2 AbM definition

<400>  72

Trp Ile Tyr Pro Gly Thr Gly Asp Ser Lys 
1               5                   10  


<210>  73
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m10C9 HCDR3 AbM definition

<400>  73

Asn Gly Asn Tyr Trp Tyr Phe Asp Val 
1               5                   


<210>  74
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m10C9 LCDR1 AbM definition

<400>  74

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  75
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m10C9 LCDR2 AbM definition

<400>  75

Arg Met Ser Asn Leu Ala Ser 
1               5           


<210>  76
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m10C9 LCDR3 AbM definition

<400>  76

Met Gln His Arg Glu Tyr Pro Phe Thr 
1               5                   


<210>  77
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m10C9 HCDR1 Kabat definition

<400>  77

Arg Tyr Tyr Ile His 
1               5   


<210>  78
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m10C9 HCDR2 Kabat definition

<400>  78

Trp Ile Tyr Pro Gly Thr Gly Asp Ser Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  79
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m10C9 HCDR3 Kabat definition

<400>  79

Asn Gly Asn Tyr Trp Tyr Phe Asp Val 
1               5                   


<210>  80
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m10C9 LCDR1 Kabat definition

<400>  80

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  81
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m10C9 LCDR2 Kabat definition

<400>  81

Arg Met Ser Asn Leu Ala Ser 
1               5           


<210>  82
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m10C9 LCDR3 Kabat definition

<400>  82

Met Gln His Arg Glu Tyr Pro Phe Thr 
1               5                   


<210>  83
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m10C9 HCDR1 Contact definition

<400>  83

Thr Arg Tyr Tyr Ile His 
1               5       


<210>  84
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m10C9 HCDR2 Contact definition

<400>  84

Trp Ile Gly Trp Ile Tyr Pro Gly Thr Gly Asp Ser Lys 
1               5                   10              


<210>  85
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m10C9 HCDR3 Contact definition

<400>  85

Ala Arg Asn Gly Asn Tyr Trp Tyr Phe Asp 
1               5                   10  


<210>  86
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m10C9 LCDR1 Contact definition

<400>  86

Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe 
1               5                   10          


<210>  87
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m10C9 LCDR2 Contact definition

<400>  87

Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala 
1               5                   10  


<210>  88
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m10C9 LCDR3 Contact definition

<400>  88

Met Gln His Arg Glu Tyr Pro Phe 
1               5               


<210>  89
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m10C9 HCDR1 IMGT definition

<400>  89

Asp Tyr Asn Phe Thr Arg Tyr Tyr 
1               5               


<210>  90
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m10C9 HCDR2 IMGT definition

<400>  90

Ile Tyr Pro Gly Thr Gly Asp Ser 
1               5               


<210>  91
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m10C9 HCDR3 IMGT definition

<400>  91

Ala Arg Asn Gly Asn Tyr Trp Tyr Phe Asp Val 
1               5                   10      


<210>  92
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m10C9 LCDR1 IMGT definition

<400>  92

Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  93
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m10C9 LCDR3 IMGT definition

<400>  93

Met Gln His Arg Glu Tyr Pro Phe Thr 
1               5                   


<210>  94
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YW327.6S2 VH

<400>  94

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Gly Ser 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Pro Tyr Arg Gly Tyr Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Ser Gly Trp Gly Gly Ser Ser Val Gly Tyr Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  95
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YW327.6S2 VL

<400>  95

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  96
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YW327.6S2 HCDR1 Chothia definition

<400>  96

Gly Phe Ser Leu Ser Gly Ser 
1               5           


<210>  97
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YW327.6S2 HCDR2 Chothia definition

<400>  97

Asn Pro Tyr Arg Gly Tyr 
1               5       


<210>  98
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YW327.6S2 HCDR3 Chothia definition

<400>  98

Glu Tyr Ser Gly Trp Gly Gly Ser Ser Val Gly Tyr Ala Met Asp Tyr 
1               5                   10                  15      


<210>  99
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YW327.6S2 LCDR1 Chothia definition

<400>  99

Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala 
1               5                   10      


<210>  100
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YW327.6S2 LCDR2 Chothia definition

<400>  100

Ser Ala Ser Phe Leu Tyr Ser 
1               5           


<210>  101
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YW327.6S2 LCDR3 Chothia definition

<400>  101

Gln Gln Ser Tyr Thr Thr Pro Pro Thr 
1               5                   


<210>  102
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YW327.6S2 HCDR1 AbM definition

<400>  102

Gly Phe Ser Leu Ser Gly Ser Trp Ile His 
1               5                   10  


<210>  103
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YW327.6S2 HCDR2 AbM definition

<400>  103

Trp Ile Asn Pro Tyr Arg Gly Tyr Ala Tyr 
1               5                   10  


<210>  104
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YW327.6S2 HCDR3 AbM definition

<400>  104

Glu Tyr Ser Gly Trp Gly Gly Ser Ser Val Gly Tyr Ala Met Asp Tyr 
1               5                   10                  15      


<210>  105
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YW327.6S2 LCDR1 AbM definition

<400>  105

Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala 
1               5                   10      


<210>  106
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YW327.6S2 LCDR2 AbM definition

<400>  106

Ser Ala Ser Phe Leu Tyr Ser 
1               5           


<210>  107
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YW327.6S2 LCDR3 AbM definition

<400>  107

Gln Gln Ser Tyr Thr Thr Pro Pro Thr 
1               5                   


<210>  108
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YW327.6S2 HCDR1 Kabat definition

<400>  108

Gly Ser Trp Ile His 
1               5   


<210>  109
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YW327.6S2 HCDR2 Kabat definition

<400>  109

Trp Ile Asn Pro Tyr Arg Gly Tyr Ala Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  110
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YW327.6S2 HCDR3 Kabat definition

<400>  110

Glu Tyr Ser Gly Trp Gly Gly Ser Ser Val Gly Tyr Ala Met Asp Tyr 
1               5                   10                  15      


<210>  111
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YW327.6S2 LCDR1 Kabat definition

<400>  111

Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala 
1               5                   10      


<210>  112
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YW327.6S2 LCDR2 Kabat definition

<400>  112

Ser Ala Ser Phe Leu Tyr Ser 
1               5           


<210>  113
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YW327.6S2 LCDR3 Kabat definition

<400>  113

Gln Gln Ser Tyr Thr Thr Pro Pro Thr 
1               5                   


<210>  114
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YW327.6S2 HCDR1 Contact definition

<400>  114

Ser Gly Ser Trp Ile His 
1               5       


<210>  115
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YW327.6S2 HCDR2 Contact definition

<400>  115

Trp Val Gly Trp Ile Asn Pro Tyr Arg Gly Tyr Ala Tyr 
1               5                   10              


<210>  116
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YW327.6S2 HCDR3 Contact definition

<400>  116

Ala Arg Glu Tyr Ser Gly Trp Gly Gly Ser Ser Val Gly Tyr Ala Met 
1               5                   10                  15      


Asp 
    


<210>  117
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YW327.6S2 LCDR1 Contact definition

<400>  117

Ser Thr Ala Val Ala Trp Tyr 
1               5           


<210>  118
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YW327.6S2 LCDR2 Contact definition

<400>  118

Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr 
1               5                   10  


<210>  119
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YW327.6S2 LCDR3 Contact definition

<400>  119

Gln Gln Ser Tyr Thr Thr Pro Pro 
1               5               


<210>  120
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YW327.6S2 HCDR1 IMGT definition

<400>  120

Gly Phe Ser Leu Ser Gly Ser Trp 
1               5               


<210>  121
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YW327.6S2 HCDR2 IMGT definition

<400>  121

Ile Asn Pro Tyr Arg Gly Tyr Ala 
1               5               


<210>  122
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YW327.6S2 HCDR3 IMGT definition

<400>  122

Ala Arg Glu Tyr Ser Gly Trp Gly Gly Ser Ser Val Gly Tyr Ala Met 
1               5                   10                  15      


Asp Tyr 
        


<210>  123
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YW327.6S2 LCDR1 IMGT definition

<400>  123

Gln Asp Val Ser Thr Ala 
1               5       


<210>  124
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YW327.6S2 LCDR3 IMGT definition

<400>  124

Gln Gln Ser Tyr Thr Thr Pro Pro Thr 
1               5                   


<210>  125
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1003A2 VH

<400>  125

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Asn Gly Gly Gly Arg Thr Tyr Tyr Pro Asp Thr Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Asp Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Thr Glu Ser Tyr Tyr Ala Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  126
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1003A2 VL

<400>  126

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Leu Gly 
1               5                   10                  15      


Asp Arg Ile Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ile Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Asn Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Leu Tyr Tyr Cys Gln Gln His Phe Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  127
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1003A2 HCDR1 Chothia definition

<400>  127

Gly Phe Thr Phe Asn Ser Tyr 
1               5           


<210>  128
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1003A2 HCDR2 Chothia definition

<400>  128

Ser Asn Gly Gly Gly Arg 
1               5       


<210>  129
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1003A2 HCDR3 Chothia definition

<400>  129

Gly Thr Thr Glu Ser Tyr Tyr Ala Leu Asp Tyr 
1               5                   10      


<210>  130
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1003A2 LCDR1 Chothia definition

<400>  130

Lys Ala Ser Gln Asp Val Ile Thr Ala Val Ala 
1               5                   10      


<210>  131
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1003A2 LCDR2 Chothia definition

<400>  131

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  132
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1003A2 LCDR3 Chothia definition

<400>  132

Gln Gln His Phe Ser Thr Pro Leu Thr 
1               5                   


<210>  133
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1003A2 HCDR1 AbM definition

<400>  133

Gly Phe Thr Phe Asn Ser Tyr Ser Met Ser 
1               5                   10  


<210>  134
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1003A2 HCDR2 AbM definition

<400>  134

Tyr Ile Ser Asn Gly Gly Gly Arg Thr Tyr 
1               5                   10  


<210>  135
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1003A2 HCDR3 AbM definition

<400>  135

Gly Thr Thr Glu Ser Tyr Tyr Ala Leu Asp Tyr 
1               5                   10      


<210>  136
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1003A2 LCDR1 AbM definition

<400>  136

Lys Ala Ser Gln Asp Val Ile Thr Ala Val Ala 
1               5                   10      


<210>  137
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1003A2 LCDR2 AbM definition

<400>  137

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  138
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1003A2 LCDR3 AbM definition

<400>  138

Gln Gln His Phe Ser Thr Pro Leu Thr 
1               5                   


<210>  139
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1003A2 HCDR1 Kabat definition

<400>  139

Ser Tyr Ser Met Ser 
1               5   


<210>  140
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1003A2 HCDR2 Kabat definition

<400>  140

Tyr Ile Ser Asn Gly Gly Gly Arg Thr Tyr Tyr Pro Asp Thr Ile Lys 
1               5                   10                  15      


Gly 
    


<210>  141
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1003A2 HCDR3 Kabat definition

<400>  141

Gly Thr Thr Glu Ser Tyr Tyr Ala Leu Asp Tyr 
1               5                   10      


<210>  142
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1003A2 LCDR1 Kabat definition

<400>  142

Lys Ala Ser Gln Asp Val Ile Thr Ala Val Ala 
1               5                   10      


<210>  143
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1003A2 LCDR2 Kabat definition

<400>  143

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  144
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1003A2 LCDR3 Kabat definition

<400>  144

Gln Gln His Phe Ser Thr Pro Leu Thr 
1               5                   


<210>  145
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1003A2 HCDR1 Contact definition

<400>  145

Asn Ser Tyr Ser Met Ser 
1               5       


<210>  146
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1003A2 HCDR2 Contact definition

<400>  146

Trp Val Ala Tyr Ile Ser Asn Gly Gly Gly Arg Thr Tyr 
1               5                   10              


<210>  147
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1003A2 HCDR3 Contact definition

<400>  147

Ala Arg Gly Thr Thr Glu Ser Tyr Tyr Ala Leu Asp 
1               5                   10          


<210>  148
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1003A2 LCDR1 Contact definition

<400>  148

Ile Thr Ala Val Ala Trp Tyr 
1               5           


<210>  149
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1003A2 LCDR1 Contact definition

<400>  149

Leu Leu Ile Tyr Trp Ala Ser Thr Arg His 
1               5                   10  


<210>  150
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1003A2 LCDR3 Contact definition

<400>  150

Gln Gln His Phe Ser Thr Pro Leu 
1               5               


<210>  151
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1003A2 HCDR1 IMGT definition

<400>  151

Gly Phe Thr Phe Asn Ser Tyr Ser 
1               5               


<210>  152
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1003A2 HCDR2 IMGT definition

<400>  152

Ile Ser Asn Gly Gly Gly Arg Thr 
1               5               


<210>  153
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1003A2 HCDR3 IMGT definition

<400>  153

Ala Arg Gly Thr Thr Glu Ser Tyr Tyr Ala Leu Asp Tyr 
1               5                   10              


<210>  154
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1003A2 LCDR1 IMGT definition

<400>  154

Gln Asp Val Ile Thr Ala 
1               5       


<210>  155
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1003A2 LCDR3 IMGT definition

<400>  155

Gln Gln His Phe Ser Thr Pro Leu Thr 
1               5                   


<210>  156
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1613F12 VH

<400>  156

Glu Val His Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Arg Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Leu Asp Pro Ala Asn Gly His Thr Lys Tyr Gly Pro Asn Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Met Thr Ser Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Tyr Gly Ser Ser Gly Leu Phe Tyr Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Thr Leu Ser Val Ser Ser 
        115                 120                 


<210>  157
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1613F12 VL

<400>  157

Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Thr Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Met Tyr Phe Cys Gln Gln His His Glu Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Glu Leu Glu Leu Lys 
            100                 105         


<210>  158
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1613F12 HCDR1 Chothia definition

<400>  158

Gly Phe Asn Ile Arg Asp Thr 
1               5           


<210>  159
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1613F12 HCDR2 Chothia definition

<400>  159

Asp Pro Ala Asn Gly His 
1               5       


<210>  160
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1613F12 HCDR3 Chothia definition

<400>  160

Gly Ala Tyr Tyr Tyr Gly Ser Ser Gly Leu Phe Tyr Phe Asp Tyr 
1               5                   10                  15  


<210>  161
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1613F12 LCDR1 Chothia definition

<400>  161

Arg Ala Ser Lys Ser Ile Ser Lys Tyr Leu Ala 
1               5                   10      


<210>  162
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1613F12 LCDR2 Chothia definition

<400>  162

Ser Gly Ser Thr Leu Gln Ser 
1               5           


<210>  163
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1613F12 LCDR3 Chothia definition

<400>  163

Gln Gln His His Glu Tyr Pro Leu Thr 
1               5                   


<210>  164
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1613F12 HCDR1 AbM definition

<400>  164

Gly Phe Asn Ile Arg Asp Thr Tyr Ile His 
1               5                   10  


<210>  165
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1613F12 HCDR2 AbM definition

<400>  165

Arg Leu Asp Pro Ala Asn Gly His Thr Lys 
1               5                   10  


<210>  166
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1613F12 HCDR3 AbM definition

<400>  166

Gly Ala Tyr Tyr Tyr Gly Ser Ser Gly Leu Phe Tyr Phe Asp Tyr 
1               5                   10                  15  


<210>  167
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1613F12 LCDR1 AbM definition

<400>  167

Arg Ala Ser Lys Ser Ile Ser Lys Tyr Leu Ala 
1               5                   10      


<210>  168
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1613F12 LCDR2 AbM definition

<400>  168

Ser Gly Ser Thr Leu Gln Ser 
1               5           


<210>  169
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1613F12 LCDR3 AbM definition

<400>  169

Gln Gln His His Glu Tyr Pro Leu Thr 
1               5                   


<210>  170
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1613F12 HCDR1 Kabat definition

<400>  170

Asp Thr Tyr Ile His 
1               5   


<210>  171
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1613F12 HCDR2 Kabat definition

<400>  171

Arg Leu Asp Pro Ala Asn Gly His Thr Lys Tyr Gly Pro Asn Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  172
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1613F12 HCDR3 Kabat definition

<400>  172

Gly Ala Tyr Tyr Tyr Gly Ser Ser Gly Leu Phe Tyr Phe Asp Tyr 
1               5                   10                  15  


<210>  173
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1613F12 LCDR1 Kabat definition

<400>  173

Arg Ala Ser Lys Ser Ile Ser Lys Tyr Leu Ala 
1               5                   10      


<210>  174
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1613F12 LCDR2 Kabat definition

<400>  174

Ser Gly Ser Thr Leu Gln Ser 
1               5           


<210>  175
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1613F12 LCDR3 Kabat definition

<400>  175

Gln Gln His His Glu Tyr Pro Leu Thr 
1               5                   


<210>  176
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1613F12 HCDR1 Contact definition

<400>  176

Arg Asp Thr Tyr Ile His 
1               5       


<210>  177
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1613F12 HCDR2 Contact definition

<400>  177

Trp Ile Gly Arg Leu Asp Pro Ala Asn Gly His Thr Lys 
1               5                   10              


<210>  178
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1613F12 HCDR3 Contact definition

<400>  178

Ala Arg Gly Ala Tyr Tyr Tyr Gly Ser Ser Gly Leu Phe Tyr Phe Asp 
1               5                   10                  15      


<210>  179
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1613F12 HCDR3 Contact definition

<400>  179

Ser Lys Tyr Leu Ala Trp Tyr 
1               5           


<210>  180
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1613F12 LCDR2 Contact definition

<400>  180

Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln 
1               5                   10  


<210>  181
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1613F12 LCDR3 Contact definition

<400>  181

Gln Gln His His Glu Tyr Pro Leu 
1               5               


<210>  182
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1613F12 HCDR1 IMGT definition

<400>  182

Gln Gln His His Glu Tyr Pro Leu 
1               5               


<210>  183
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1613F12 HCDR2 IMGT definition

<400>  183

Leu Asp Pro Ala Asn Gly His Thr 
1               5               


<210>  184
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1613F12 HCDR3 IMGT definition

<400>  184

Ala Arg Gly Ala Tyr Tyr Tyr Gly Ser Ser Gly Leu Phe Tyr Phe Asp 
1               5                   10                  15      


Tyr 
    


<210>  185
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1613F12 LCDR1 IMGT definition

<400>  185

Lys Ser Ile Ser Lys Tyr 
1               5       


<210>  186
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1613F12 LCDR3 IMGT definition

<400>  186

Gln Gln His His Glu Tyr Pro Leu Thr 
1               5                   


<210>  187
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  110D7 VH

<400>  187

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Asn Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Arg Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ser Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  188
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  110D7 VH

<400>  188

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Thr Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Leu Tyr Tyr Cys Gln Gln His Tyr Arg Ile Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  189
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  110D7 HCDR1 Chothia definition

<400>  189

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Thr Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Leu Tyr Tyr Cys Gln Gln His Tyr Arg Ile Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  190
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  110D7 HCDR2 Chothia definition

<400>  190

Ser Asn Gly Gly Gly Ser 
1               5       


<210>  191
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  110D7 HCDR3 Chothia definition

<400>  191

Leu Ser Phe Tyr Ala Met Asp Tyr 
1               5               


<210>  192
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  110D7 LCDR1 Chothia definition

<400>  192

Lys Ala Ser Gln Asp Val Thr Thr Ala Val Ala 
1               5                   10      


<210>  193
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  110D7 LCDR2 Chothia definition

<400>  193

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  194
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  110D7 LCDR3 Chothia definition

<400>  194

Gln Gln His Tyr Arg Ile Pro Phe Thr 
1               5                   


<210>  195
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  110D7 HCDR1 AbM definition

<400>  195

Gly Phe Thr Phe Ser Asp Tyr Tyr Met Tyr 
1               5                   10  


<210>  196
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  110D7 HCDR2 AbM definition

<400>  196

Tyr Ile Ser Asn Gly Gly Gly Ser Thr Tyr 
1               5                   10  


<210>  197
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  110D7 HCDR3 AbM definition

<400>  197

Leu Ser Phe Tyr Ala Met Asp Tyr 
1               5               


<210>  198
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  110D7 LCDR1 AbM definition

<400>  198

Lys Ala Ser Gln Asp Val Thr Thr Ala Val Ala 
1               5                   10      


<210>  199
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  110D7 LCDR2 AbM definition

<400>  199

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  200
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  110D7 LCDR3 AbM definition

<400>  200

Gln Gln His Tyr Arg Ile Pro Phe Thr 
1               5                   


<210>  201
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  110D7 HCDR1 Kabat definition

<400>  201

Asp Tyr Tyr Met Tyr 
1               5   


<210>  202
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  110D7 HCDR2 Kabat definition

<400>  202

Tyr Ile Ser Asn Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  203
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  110D7 HCDR3 Kabat definition

<400>  203

Leu Ser Phe Tyr Ala Met Asp Tyr 
1               5               


<210>  204
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  110D7 LCDR1 Kabat definition

<400>  204

Lys Ala Ser Gln Asp Val Thr Thr Ala Val Ala 
1               5                   10      


<210>  205
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  110D7 LCDR2 Kabat definition

<400>  205

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  206
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  110D7 LCDR3 Kabat definition

<400>  206

Gln Gln His Tyr Arg Ile Pro Phe Thr 
1               5                   


<210>  207
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  110D7 HCDR1 Contact definition

<400>  207

Ser Asp Tyr Tyr Met Tyr 
1               5       


<210>  208
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  110D7 HCDR2 Contact definition

<400>  208

Trp Val Ala Tyr Ile Ser Asn Gly Gly Gly Ser Thr Tyr 
1               5                   10              


<210>  209
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  110D7 HCDR3 Contact definition

<400>  209

Ala Arg Leu Ser Phe Tyr Ala Met Asp 
1               5                   


<210>  210
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  110D7 LCDR1 Contact definition

<400>  210

Thr Thr Ala Val Ala Trp Tyr 
1               5           


<210>  211
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  110D7 LCDR2 Contact definition

<400>  211

Leu Leu Ile Tyr Trp Ala Ser Thr Arg His 
1               5                   10  


<210>  212
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  110D7 LCDR3 Contact definition

<400>  212

Gln Gln His Tyr Arg Ile Pro Phe 
1               5               


<210>  213
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  110D7 HCDR1 IMGT definition

<400>  213

Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  214
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  110D7 HCDR2 IMGT definition

<400>  214

Ile Ser Asn Gly Gly Gly Ser Thr 
1               5               


<210>  215
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  110D7 HCDR3 IMGT definition

<400>  215

Ala Arg Leu Ser Phe Tyr Ala Met Asp Tyr 
1               5                   10  


<210>  216
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  110D7 LCDR1 IMGT definition

<400>  216

Gln Asp Val Thr Thr Ala 
1               5       


<210>  217
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  110D7 LCDR3 IMGT definition

<400>  217

Gln Gln His Tyr Arg Ile Pro Phe Thr 
1               5                   


<210>  218
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1024G11 VH

<400>  218

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Asn Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Asn Gly Gly Gly Arg Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Phe Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Asn Ser Glu Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Thr Thr Glu Ser Tyr Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  219
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1024G11 VL

<400>  219

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ile Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Leu Tyr Phe Cys Gln Gln His Leu Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  220
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1024G11 HCDR1 Chothia definition

<400>  220

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  221
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1024G11 HCDR2 Chothia definition

<400>  221

Ser Asn Gly Gly Gly Arg 
1               5       


<210>  222
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1024G11 HCDR3 Chothia definition

<400>  222

Gly Thr Thr Glu Ser Tyr Tyr Ala Met Asp Tyr 
1               5                   10      


<210>  223
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1024G11 LCDR1 Chothia definition

<400>  223

Lys Ala Ser Gln Asp Val Ile Thr Ala Val Ala 
1               5                   10      


<210>  224
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1024G11 LCDR2 Chothia definition

<400>  224

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  225
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1024G11 LCDR3 Chothia definition

<400>  225

Gln Gln His Leu Ser Thr Pro Leu Thr 
1               5                   


<210>  226
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1024G11 HCDR1 AbM definition

<400>  226

Gly Phe Thr Phe Ser Ser Tyr Ser Met Ser 
1               5                   10  


<210>  227
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1024G11 HCDR2 AbM definition

<400>  227

Phe Ile Ser Asn Gly Gly Gly Arg Thr Tyr 
1               5                   10  


<210>  228
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1024G11 HCDR3 AbM definition

<400>  228

Gly Thr Thr Glu Ser Tyr Tyr Ala Met Asp Tyr 
1               5                   10      


<210>  229
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1024G11 LCDR1 AbM definition

<400>  229

Lys Ala Ser Gln Asp Val Ile Thr Ala Val Ala 
1               5                   10      


<210>  230
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1024G11 LCDR1 AbM definition

<400>  230

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  231
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1024G11 LCDR3 AbM definition

<400>  231

Gln Gln His Leu Ser Thr Pro Leu Thr 
1               5                   


<210>  232
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1024G11 HCDR1 Kabat definition

<400>  232

Ser Tyr Ser Met Ser 
1               5   


<210>  233
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1024G11 HCDR2 Kabat definition

<400>  233

Phe Ile Ser Asn Gly Gly Gly Arg Thr Tyr Tyr Pro Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  234
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1024G11 HCDR3 Kabat definition

<400>  234

Gly Thr Thr Glu Ser Tyr Tyr Ala Met Asp Tyr 
1               5                   10      


<210>  235
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1024G11 LCDR1 Kabat definition

<400>  235

Lys Ala Ser Gln Asp Val Ile Thr Ala Val Ala 
1               5                   10      


<210>  236
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1024G11 LCDR2 Kabat definition

<400>  236

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  237
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1024G11 LCDR3 Kabat definition

<400>  237

Gln Gln His Leu Ser Thr Pro Leu Thr 
1               5                   


<210>  238
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1024G11 HCDR1 Contact definition

<400>  238

Ser Ser Tyr Ser Met Ser 
1               5       


<210>  239
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1024G11 HCDR2 Contact definition

<400>  239

Trp Val Ala Phe Ile Ser Asn Gly Gly Gly Arg Thr Tyr 
1               5                   10              


<210>  240
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1024G11 HCDR3 Contact definition

<400>  240

Ala Arg Gly Thr Thr Glu Ser Tyr Tyr Ala Met Asp 
1               5                   10          


<210>  241
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1024G11 LCDR1 Contact definition

<400>  241

Ile Thr Ala Val Ala Trp Tyr 
1               5           


<210>  242
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1024G11 LCDR2 Contact definition

<400>  242

Leu Leu Ile Tyr Trp Ala Ser Thr Arg His 
1               5                   10  


<210>  243
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1024G11 LCDR3 Contact definition

<400>  243

Gln Gln His Leu Ser Thr Pro Leu 
1               5               


<210>  244
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1024G11 HCDR1 IMGT definition

<400>  244

Gly Phe Thr Phe Ser Ser Tyr Ser 
1               5               


<210>  245
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1024G11 HCDR2 IMGT definition

<400>  245

Ile Ser Asn Gly Gly Gly Arg Thr 
1               5               


<210>  246
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1024G11 HCDR3 IMGT definition

<400>  246

Ala Arg Gly Thr Thr Glu Ser Tyr Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  247
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1024G11 LCDR1 IMGT definition

<400>  247

Gln Asp Val Ile Thr Ala 
1               5       


<210>  248
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1024G11 LCDR2 IMGT definition

<400>  248

Gln Gln His Leu Ser Thr Pro Leu Thr 
1               5                   


