                         SEQUENCE LISTING

<110>  NOVIMMUNE SA
 
<120>  BISPECIFIC ANTIBODIES TARGETING CD47 AND PD-L1 AND METHODS OF USE
        THEREOF

<130>  NOVI-047/001WO 322145-2971

<150>  63/317,892
<151>  2022-03-08

<150>  63/164,237
<151>  2021-03-22

<160>  210   

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1

<400>  1

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  2

Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3

<400>  3

Ala Lys Ser Tyr Gly Ala Phe Asp Tyr 
1               5                   


<210>  4
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHCH  IGHV3-23 hIgG1-AA

<400>  4

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Tyr Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210>  5
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHCH  IGHV3-23 hIgG1-NT

<400>  5
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaagttat      300

ggtgcttttg actactgggg ccagggaacc ctggtcacag tctcgagcgc ctccaccaag      360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cagtctcgtg gaactcagga      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgactgt gccctccagc agcttgggca cccagaccta catctgcaac      600

gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac      660

aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtataccctg cccccatctc gggaggagat gaccaagaac     1080

caggtcagcc tgacttgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaacg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctatag caagctcacc gtggacaagt ccaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tccctgtctc cgggttaa                                                   1338


<210>  6
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH  IGHV3-23 hIgG1-AA

<400>  6

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Tyr Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  7
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHCH IGHV3-23 hIgG1-NT

<400>  7
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaagttat      300

ggtgcttttg actactgggg ccagggaacc ctggtcacag tctcgagc                   348


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1-CDRL1-1

<400>  8

Ser Ser Asn Ile Arg Asp Ser Phe 
1               5               


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1-CDRL1-2

<400>  9

Ser Ser Asp Val Val Lys Asn Asn Phe 
1               5                   


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1-CDRL1-3

<400>  10

Ser Ser Asn Ile Ala His Lys Pro 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1-CDRL1-4

<400>  11

Ser Val Asp Ile Ala His Lys Pro 
1               5               


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1-CDRL1-5

<400>  12

Ser Ser Asp Val Ala Lys Ile Pro Leu 
1               5                   


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1-CDRL1-6

<400>  13

Ser Ser Asp Val Leu Arg Pro Pro Leu 
1               5                   


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1-CDRL1-7

<400>  14

Ser Ser Asp Val Phe Arg Pro Pro Leu 
1               5                   


<210>  15
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1-CDRL2-1

<400>  15

Ala Thr Asn 
1           


<210>  16
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1-CDRL2-2

<400>  16

Phe Gly Ser 
1           


<210>  17
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1-CDRL2-3

<400>  17

His Asp Asn 
1           


<210>  18
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1-CDRL2-4

<400>  18

His Asp Thr 
1           


<210>  19
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1-CDRL2-5

<400>  19

Phe Ala Ser 
1           


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1-CDRL3-1

<400>  20

Ala Ala Trp His Pro Tyr Tyr Thr Leu 
1               5                   


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1-CDRL3-2

<400>  21

Ala Ser Trp Trp Pro Tyr Gly Thr Val 
1               5                   


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1-CDRL3-3

<400>  22

Ala Ser Trp Trp Pro Phe Gly Thr Val 
1               5                   


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1-CDRL3-4

<400>  23

Ser Ser Trp Asp Met Pro Ala Leu Phe 
1               5                   


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1-CDRL3-5

<400>  24

Ser Ser Trp Asp Glu Pro Asp Arg Pro 
1               5                   


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1-CDRL3-6

<400>  25

Ser Ser Trp Asp Leu Pro Phe Leu Met 
1               5                   


<210>  26
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1-CDRL3-9

<400>  26

Ser Ser Trp Asp Asn Ala Gly Asp Gly His Val 
1               5                   10      


<210>  27
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1-CDRL3-10

<400>  27

Ser Ser Trp Asp Gln Ser Gly Asp Gly His Val 
1               5                   10      


<210>  28
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1-CDRL3-11

<400>  28

Ser Ser Trp Asp His Thr Gly Asp Gly His Val 
1               5                   10      


<210>  29
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S8_Sa10_1A9_VLCL2 aPDL1 IGLV1-44-AA

<400>  29

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Arg Asp Ser 
            20                  25                  30          


Phe Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Thr Asn Ile Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp His Pro Tyr Tyr 
                85                  90                  95      


Thr Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  30
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S8_Sa10_1A9_VLCL2 aPDL1 IGLV1-44-NT

<400>  30
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcagg gatagttttg taaactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat gctacgaata ttcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gcatggcacc cgtattacac gttgttcggc      300

ggagggacca agctgaccgt cctaggtcag cccaaggctg ccccctcggt cactctgttc      360

ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      420

ttctacccgg gagccgtgac agtggcttgg aaagcagata gcagccccgt caaggcggga      480

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctatctg      540

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      600

gggagcaccg tggagaagac agtggcccct acagaatgtt ca                         642


<210>  31
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S8_Sa10_1A9_VLCL2 aPDL1 IGLV1-44-AA

<400>  31

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Arg Asp Ser 
            20                  25                  30          


Phe Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Thr Asn Ile Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp His Pro Tyr Tyr 
                85                  90                  95      


Thr Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu 
        115                 


<210>  32
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S8_Sa10_1A9_VLCL2 aPDL1 IGLV1-44-NT

<400>  32
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcagg gatagttttg taaactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat gctacgaata ttcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gcatggcacc cgtattacac gttgttcggc      300

ggagggacca agctgaccgt cctaggtcag cccaaggctg ccccctcggt cactctg         357


<210>  33
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S9_Sa10_1D9_VLCL2 aPDL1 IGLV1-44-AA

<400>  33

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Arg Asp Ser 
            20                  25                  30          


Phe Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Thr Asn Ile Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Trp Pro Tyr Gly 
                85                  90                  95      


Thr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  34
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S9_Sa10_1D9_VLCL2 aPDL1 IGLV1-44-NT

<400>  34
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcagg gatagttttg taaactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat gctacgaata ttcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca tcgtggtggc cgtacggtac tgtgttcggc      300

ggagggacca agctgaccgt cctaggtcag cccaaggctg ccccctcggt cactctgttc      360

ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      420

ttctacccgg gagccgtgac agtggcttgg aaagcagata gcagccccgt caaggcggga      480

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctatctg      540

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      600

gggagcaccg tggagaagac agtggcccct acagaatgtt ca                         642


<210>  35
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S9_Sa10_1D9_VLCL2 aPDL1 IGLV1-44-AA

<400>  35

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Arg Asp Ser 
            20                  25                  30          


Phe Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Thr Asn Ile Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Trp Pro Tyr Gly 
                85                  90                  95      


Thr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu 
        115                 


<210>  36
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S9_Sa10_1D9_VLCL2 aPDL1 IGLV1-44-NT

<400>  36
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcagg gatagttttg taaactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat gctacgaata ttcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca tcgtggtggc cgtacggtac tgtgttcggc      300

ggagggacca agctgaccgt cctaggtcag cccaaggctg ccccctcggt cactctg         357


<210>  37
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S37_ Sa10_1D7_VLCL2 aPDL1 IGLV1-44-AA

<400>  37

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Arg Asp Ser 
            20                  25                  30          


Phe Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Thr Asn Ile Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Trp Pro Phe Gly 
                85                  90                  95      


Thr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  38
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S37_ Sa10_1D7_VLCL2 aPDL1 IGLV1-44-NT

<400>  38
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcagg gatagttttg taaactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat gctacgaata ttcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca tcctggtggc cgttcggtac tgtgttcggc      300

ggagggacca agctgaccgt cctaggtcag cccaaggctg ccccctcggt cactctgttc      360

ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      420

ttctacccgg gagccgtgac agtggcttgg aaagcagata gcagccccgt caaggcggga      480

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctatctg      540

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      600

gggagcaccg tggagaagac agtggcccct acagaatgtt ca                         642


<210>  39
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S37_ Sa10_1D7_VLCL2 aPDL1 IGLV1-44-AA

<400>  39

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Arg Asp Ser 
            20                  25                  30          


Phe Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Thr Asn Ile Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Trp Pro Phe Gly 
                85                  90                  95      


Thr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu 
        115                 


<210>  40
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S37_ Sa10_1D7_VLCL2 aPDL1 IGLV1-44-NT

<400>  40
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcagg gatagttttg taaactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat gctacgaata ttcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca tcctggtggc cgttcggtac tgtgttcggc      300

ggagggacca agctgaccgt cctaggtcag cccaaggctg ccccctcggt cactctg         357


<210>  41
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S14_ Sh3_1C6_VLCL2 aPDL1 IGLV2-23-AA

<400>  41

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Val Lys Asn 
            20                  25                  30          


Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Phe Gly Ser Val Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Met Pro Ala 
                85                  90                  95      


Leu Phe Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  42
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S14_ Sh3_1C6_VLCL2 aPDL1 IGLV2-23-NT

<400>  42
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttgtt aagaataatt ttgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tattttggga gtgttcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatggg atatgcctgc gcttttcttc      300

ggcggaggga ccaagctgac cgtcctaggt cagcccaagg ctgccccctc ggtcactctg      360

ttcccgccct cctctgagga gcttcaagcc aacaaggcca cactggtgtg tctcataagt      420

gacttctacc cgggagccgt gacagtggct tggaaagcag atagcagccc cgtcaaggcg      480

ggagtggaga ccaccacacc ctccaaacaa agcaacaaca agtacgcggc cagcagctat      540

ctgagcctga cgcctgagca gtggaagtcc cacagaagct acagctgcca ggtcacgcat      600

gaagggagca ccgtggagaa gacagtggcc cctacagaat gttca                      645


<210>  43
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S14_ Sh3_1C6_VLCL2 aPDL1 IGLV2-23-AA

<400>  43

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Val Lys Asn 
            20                  25                  30          


Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Phe Gly Ser Val Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Met Pro Ala 
                85                  90                  95      


Leu Phe Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu 
        115                 


<210>  44
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S14_ Sh3_1C6_VLCL2 aPDL1 IGLV2-23-NT

<400>  44
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttgtt aagaataatt ttgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tattttggga gtgttcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatggg atatgcctgc gcttttcttc      300

ggcggaggga ccaagctgac cgtcctaggt cagcccaagg ctgccccctc ggtcactctg      360


<210>  45
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S15_ Sh3_1E2_VLCL2 aPDL1 IGLV2-23-AA

<400>  45

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Val Lys Asn 
            20                  25                  30          


Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Phe Gly Ser Val Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Glu Pro 
                85                  90                  95      


Asp Arg Pro Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu Cys Ser 
    210                 215 


<210>  46
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S15_ Sh3_1E2_VLCL2 aPDL1 IGLV2-23-NT

<400>  46
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttgtt aagaataatt ttgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tattttggga gtgttcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatggg atgagccgga caggcccttc      300

ggcggaggga ccaagctgac cgtcctaggt cagcccaagg ctgccccctc ggtcactctg      360

ttcccgccct cctctgagga gcttcaagcc aacaaggcca cactggtgtg tctcataagt      420

gacttctacc cgggagccgt gacagtggct tggaaagcag atagcagccc cgtcaaggcg      480

ggagtggaga ccaccacacc ctccaaacaa agcaacaaca agtacgcggc cagcagctat      540

ctgagcctga cgcctgagca gtggaagtcc cacagaagct acagctgcca ggtcacgcat      600

gaagggagca ccgtggagaa gacagtggcc cctacagaat gttca                      645


<210>  47
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S15_ Sh3_1E2_VLCL2 aPDL1 IGLV2-23-AA

<400>  47

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Val Lys Asn 
            20                  25                  30          


Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Phe Gly Ser Val Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Glu Pro 
                85                  90                  95      


Asp Arg Pro Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu 
        115                 120 


<210>  48
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S15_ Sh3_1E2_VLCL2 aPDL1 IGLV2-23-NT

<400>  48
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttgtt aagaataatt ttgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tattttggga gtgttcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatggg atgagccgga caggcccttc      300

ggcggaggga ccaagctgac cgtcctaggt cagcccaagg ctgccccctc ggtcactctg      360


<210>  49
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S17_ Sh3_1D9_VLCL2 aPDL1 IGLV2-23-AA


<220>
<221>  misc_feature
<222>  (102)..(102)
<223>  Xaa can be any naturally occurring amino acid

<400>  49

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Val Lys Asn 
            20                  25                  30          


Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Pro 
        35                  40                  45              


Met Ile Tyr Phe Gly Ser Val Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Leu Pro 
                85                  90                  95      


Phe Leu Met Phe Gly Xaa Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu Cys Ser 
    210                 215 


<210>  50
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S17_ Sh3_1D9_VLCL2 aPDL1 IGLV2-23-NT

<400>  50
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttgtt aagaataatt ttgtctcctg gtaccaacag      120

cacccaggca aagcccccaa acccatgatt tattttggga gtgttcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatggg atctcccttt ccttatgttc      300

ggcggrggga ccaagctgac cgtcctaggt cagcccaagg ctgccccctc ggtcactctg      360

ttcccgccct cctctgagga gcttcaagcc aacaaggcca cactggtgtg tctcataagt      420

gacttctacc cgggagccgt gacagtggct tggaaagcag atagcagccc cgtcaaggcg      480

ggagtggaga ccaccacacc ctccaaacaa agcaacaaca agtacgcggc cagcagctat      540

ctgagcctga cgcctgagca gtggaagtcc cacagaagct acagctgcca ggtcacgcat      600

gaagggagca ccgtggagaa gacagtggcc cctacagaat gttca                      645


<210>  51
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S17_ Sh3_1D9_VLCL2 aPDL1 IGLV2-23-AA


<220>
<221>  misc_feature
<222>  (102)..(102)
<223>  Xaa can be any naturally occurring amino acid

<400>  51

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Val Lys Asn 
            20                  25                  30          


Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Pro 
        35                  40                  45              


Met Ile Tyr Phe Gly Ser Val Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Leu Pro 
                85                  90                  95      


Phe Leu Met Phe Gly Xaa Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu 
        115                 120 


<210>  52
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S17_ Sh3_1D9_VLCL2 aPDL1 IGLV2-23-NT

<400>  52
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttgtt aagaataatt ttgtctcctg gtaccaacag      120

cacccaggca aagcccccaa acccatgatt tattttggga gtgttcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatggg atctcccttt ccttatgttc      300

ggcggrggga ccaagctgac cgtcctaggt cagcccaagg ctgccccctc ggtcactctg      360


<210>  53
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S57_ Sh3_2D9_VLCL2 aPDL1 IGLV2-23-AA

<400>  53

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Ser Ile Ser Ser Asp Val Val Lys Asn 
            20                  25                  30          


Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Phe Gly Ser Val Thr Ala Asp Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Glu Pro 
                85                  90                  95      


Asp Arg Pro Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu Cys Ser 
    210                 215 


<210>  54
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S57_ Sh3_2D9_VLCL2 aPDL1 IGLV2-23-NT

<400>  54
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcacta gtattagcag tgacgttgtt aagaataatt ttgtctcttg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tattttggga gtgttactgc tgatggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatggg atgagccgga caggcccttc      300

ggcggaggga ccaagctgac cgtcctaggt cagcccaagg ctgccccctc ggtcactctg      360

ttcccgccct cctctgagga gcttcaagcc aacaaggcca cactggtgtg tctcataagt      420

gacttctacc cgggagccgt gacagtggct tggaaagcag atagcagccc cgtcaaggcg      480

ggagtggaga ccaccacacc ctccaaacaa agcaacaaca agtacgcggc cagcagctat      540

ctgagcctga cgcctgagca gtggaagtcc cacagaagct acagctgcca ggtcacgcat      600

gaagggagca ccgtggagaa gacagtggcc cctacagaat gttca                      645


<210>  55
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S57_ Sh3_2D9_VLCL2 aPDL1 IGLV2-23-AA

<400>  55

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Ser Ile Ser Ser Asp Val Val Lys Asn 
            20                  25                  30          


Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Phe Gly Ser Val Thr Ala Asp Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Glu Pro 
                85                  90                  95      


Asp Arg Pro Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu 
        115                 120 


<210>  56
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S57_ Sh3_2D9_VLCL2 aPDL1 IGLV2-23-NT

<400>  56
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcacta gtattagcag tgacgttgtt aagaataatt ttgtctcttg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tattttggga gtgttactgc tgatggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatggg atgagccgga caggcccttc      300

ggcggaggga ccaagctgac cgtcctaggt cagcccaagg ctgccccctc ggtcactctg      360


<210>  57
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S58_ Sh3_1G5_VLCL2 aPDL1 IGLV2-23-AA

<400>  57

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Asn Ser Pro Ser Ser Asp Val Val Lys Asn 
            20                  25                  30          


Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Phe Gly Ser Val Thr Gly Pro Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Glu Pro 
                85                  90                  95      


Asp Arg Pro Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu Cys Ser 
    210                 215 


<210>  58
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S58_ Sh3_1G5_VLCL2 aPDL1 IGLV2-23-NT

<400>  58
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcaata gtcctagcag tgacgttgtt aagaataatt ttgtctcttg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tattttggga gtgttactgg tcctggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatggg atgagccgga caggcccttc      300

ggcggaggga ccaagctgac cgtcctaggt cagcccaagg ctgccccctc ggtcactctg      360

ttcccgccct cctctgagga gcttcaagcc aacaaggcca cactggtgtg tctcataagt      420

gacttctacc cgggagccgt gacagtggct tggaaagcag atagcagccc cgtcaaggcg      480

ggagtggaga ccaccacacc ctccaaacaa agcaacaaca agtacgcggc cagcagctat      540

ctgagcctga cgcctgagca gtggaagtcc cacagaagct acagctgcca ggtcacgcat      600

gaagggagca ccgtggagaa gacagtggcc cctacagaat gttca                      645


<210>  59
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S58_ Sh3_1G5_VLCL2 aPDL1 IGLV2-23-AA

<400>  59

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Asn Ser Pro Ser Ser Asp Val Val Lys Asn 
            20                  25                  30          


Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Phe Gly Ser Val Thr Gly Pro Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Glu Pro 
                85                  90                  95      


Asp Arg Pro Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu 
        115                 120 


<210>  60
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S58_ Sh3_1G5_VLCL2 aPDL1 IGLV2-23-NT

<400>  60
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcaata gtcctagcag tgacgttgtt aagaataatt ttgtctcttg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tattttggga gtgttactgg tcctggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatggg atgagccgga caggcccttc      300

ggcggaggga ccaagctgac cgtcctaggt cagcccaagg ctgccccctc ggtcactctg      360


<210>  61
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S28_Sa2_1G7_VLCL2 aPDL1 IGLV2-44-AA

<400>  61

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Ala His Lys 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr His Asp Asn Ser Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Phe Ala Thr 
                85                  90                  95      


Trp Pro Ala Thr Glu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
        115                 120                 125             


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
    130                 135                 140                 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
145                 150                 155                 160 


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
                165                 170                 175     


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
            180                 185                 190         


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
        195                 200                 205             


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215             


<210>  62
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S28_Sa2_1G7_VLCL2 aPDL1 IGLV2-44-NT

<400>  62
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgct cataagcctg taaactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat catgataatt ctcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gcatgggatt tcgcgacgtg gccggctact      300

gaggtgttcg gcggagggac caagctgacc gtcctaggtc agcccaaggc tgccccctcg      360

gtcactctgt tcccgccctc ctctgaggag cttcaagcca acaaggccac actggtgtgt      420

ctcataagtg acttctaccc gggagccgtg acagtggctt ggaaagcaga tagcagcccc      480

gtcaaggcgg gagtggagac caccacaccc tccaaacaaa gcaacaacaa gtacgcggcc      540

agcagctatc tgagcctgac gcctgagcag tggaagtccc acagaagcta cagctgccag      600

gtcacgcatg aagggagcac cgtggagaag acagtggccc ctacagaatg ttca            654


<210>  63
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S28_Sa2_1G7_VLCL2 aPDL1 IGLV2-44-AA

<400>  63

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Ala His Lys 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr His Asp Asn Ser Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Phe Ala Thr 
                85                  90                  95      


Trp Pro Ala Thr Glu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu 
        115                 120             


<210>  64
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S28_Sa2_1G7_VLCL2 aPDL1 IGLV2-44-NT

<400>  64
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgct cataagcctg taaactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat catgataatt ctcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gcatgggatt tcgcgacgtg gccggctact      300

gaggtgttcg gcggagggac caagctgacc gtcctaggtc agcccaaggc tgccccctcg      360

gtcactctg                                                              369


<210>  65
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S30_ Sa2_C10_VLCL2 aPDL1 IGLV2-44-AA

<400>  65

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Ala His Lys 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr His Asp Asn Ser Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Arg Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Phe Ser Arg 
                85                  90                  95      


Trp Pro Ala Thr Glu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
        115                 120                 125             


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
    130                 135                 140                 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
145                 150                 155                 160 


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
                165                 170                 175     


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
            180                 185                 190         


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
        195                 200                 205             


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215             


<210>  66
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S30_ Sa2_C10_VLCL2 aPDL1 IGLV2-44-NT

<400>  66
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgct cataagcctg taaactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat catgataatt ctcggccctc aggggtccct      180

gaccgattct ctggctccag gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gcatgggatt tcagccgctg gccggctact      300

gaggtgttcg gcggagggac caagctgacc gtcctaggtc agcccaaggc tgccccctcg      360

gtcactctgt tcccgccctc ctctgaggag cttcaagcca acaaggccac actggtgtgt      420

ctcataagtg acttctaccc gggagccgtg acagtggctt ggaaagcaga tagcagcccc      480

gtcaaggcgg gagtggagac caccacaccc tccaaacaaa gcaacaacaa gtacgcggcc      540

agcagctatc tgagcctgac gcctgagcag tggaagtccc acagaagcta cagctgccag      600

gtcacgcatg aagggagcac cgtggagaag acagtggccc ctacagaatg ttca            654


<210>  67
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S30_ Sa2_C10_VLCL2 aPDL1 IGLV2-44-AA

<400>  67

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Ala His Lys 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr His Asp Asn Ser Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Arg Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Phe Ser Arg 
                85                  90                  95      


Trp Pro Ala Thr Glu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu 
        115                 120             


<210>  68
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S30_ Sa2_C10_VLCL2 aPDL1 IGLV2-44-NT

<400>  68
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgct cataagcctg taaactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat catgataatt ctcggccctc aggggtccct      180

gaccgattct ctggctccag gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gcatgggatt tcagccgctg gccggctact      300

gaggtgttcg gcggagggac caagctgacc gtcctaggtc agcccaaggc tgccccctcg      360

gtcactctg                                                              369


<210>  69
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S94_Sa2_G11_VLCL2 aPDL1 IGLV1-44-AA

<400>  69

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ile Ser Gly Ser Val Asp Ile Ala His Lys 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr His Asp Thr Ser Thr Pro Asp Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Phe Ala Thr 
                85                  90                  95      


Trp Pro Ala Thr Glu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
        115                 120                 125             


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
    130                 135                 140                 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
145                 150                 155                 160 


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
                165                 170                 175     


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
            180                 185                 190         


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
        195                 200                 205             


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215             


<210>  70
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S94_Sa2_G11_VLCL2 aPDL1 IGLV1-44-NT

<400>  70
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgtatta gtggtagcgt tgatatcgct cataagcctg taaactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat catgatacct ctactcctga tggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gcatgggatt tcgcgacgtg gccggctact      300

gaggtgttcg gcggagggac caagctgacc gtcctaggtc agcccaaggc tgccccctcg      360

gtcactctgt tcccgccctc ctctgaggag cttcaagcca acaaggccac actggtgtgt      420

ctcataagtg acttctaccc gggagccgtg acagtggctt ggaaagcaga tagcagcccc      480

gtcaaggcgg gagtggagac caccacaccc tccaaacaaa gcaacaacaa gtacgcggcc      540

agcagctatc tgagcctgac gcctgagcag tggaagtccc acagaagcta cagctgccag      600

gtcacgcatg aagggagcac cgtggagaag acagtggccc ctacagaatg ttcataa         657


<210>  71
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S94_Sa2_G11_VLCL2 aPDL1 IGLV1-44-AA

<400>  71

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ile Ser Gly Ser Val Asp Ile Ala His Lys 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr His Asp Thr Ser Thr Pro Asp Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Phe Ala Thr 
                85                  90                  95      


Trp Pro Ala Thr Glu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu 
        115                 120             


<210>  72
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S94_Sa2_G11_VLCL2 aPDL1 IGLV1-44-NT

<400>  72
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgtatta gtggtagcgt tgatatcgct cataagcctg taaactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat catgatacct ctactcctga tggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gcatgggatt tcgcgacgtg gccggctact      300

gaggtgttcg gcggagggac caagctgacc gtcctaggtc agcccaaggc tgccccctcg      360

gtcactctg                                                              369


<210>  73
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S23_ Sc3_1H4_VLCL2 aPDL1 IGLV2-23-AA

<400>  73

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Ala Lys Ile 
            20                  25                  30          


Pro Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Phe Ala Ser Leu Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Asn Ala 
                85                  90                  95      


Gly Asp Gly His Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  74
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S23_ Sc3_1H4_VLCL2 aPDL1 IGLV2-23-NT

<400>  74
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttgct aagattcctc ttgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tattttgcta gtcttcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatggg ataatgctgg tgatgggcat      300

gtgttcggcg gagggaccaa gctgaccgtc ctaggtcagc ccaaggctgc cccctcggtc      360

actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcttgga aagcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc a               651


<210>  75
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S23_ Sc3_1H4_VLCL2 aPDL1 IGLV2-23-AA

<400>  75

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Ala Lys Ile 
            20                  25                  30          


Pro Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Phe Ala Ser Leu Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Asn Ala 
                85                  90                  95      


Gly Asp Gly His Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu 
        115                 120         


<210>  76
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S23_ Sc3_1H4_VLCL2 aPDL1 IGLV2-23-NT

<400>  76
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttgct aagattcctc ttgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tattttgcta gtcttcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatggg ataatgctgg tgatgggcat      300

gtgttcggcg gagggaccaa gctgaccgtc ctaggtcagc ccaaggctgc cccctcggtc      360

actctg                                                                 366


<210>  77
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S46_ Sc3_1E4_VLCL2 aPDL1 IGLV2-23-AA

<400>  77

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Leu Arg Pro 
            20                  25                  30          


Pro Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Phe Ala Ser Leu Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Asn Ala 
                85                  90                  95      


Gly Asp Gly His Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  78
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S46_ Sc3_1E4_VLCL2 aPDL1 IGLV2-23-NT

<400>  78
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttctt aggcctcctc ttgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tattttgcta gtcttcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatggg ataatgctgg tgatgggcat      300

gtgttcggcg gagggaccaa gctgaccgtc ctaggtcagc ccaaggctgc cccctcggtc      360

actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcttgga aagcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc a               651


<210>  79
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S46_ Sc3_1E4_VLCL2 aPDL1 IGLV2-23-AA

<400>  79

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Leu Arg Pro 
            20                  25                  30          


Pro Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Phe Ala Ser Leu Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Asn Ala 
                85                  90                  95      


Gly Asp Gly His Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu 
        115                 120         


<210>  80
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S46_ Sc3_1E4_VLCL2 aPDL1 IGLV2-23-NT

<400>  80
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttctt aggcctcctc ttgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tattttgcta gtcttcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatggg ataatgctgg tgatgggcat      300

gtgttcggcg gagggaccaa gctgaccgtc ctaggtcagc ccaaggctgc cccctcggtc      360

actctg                                                                 366


<210>  81
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S71_ Sc3_2C6_VLCL2 aPDL1 IGLV2-23-AA

<400>  81

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Phe Arg Pro 
            20                  25                  30          


Pro Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Phe Ala Ser Leu Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Gln Ser 
                85                  90                  95      


Gly Asp Gly His Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  82
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S71_ Sc3_2C6_VLCL2 aPDL1 IGLV2-23-NT

<400>  82
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttttt aggcctcctc ttgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tattttgcta gtcttcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatggg atcagtccgg ggacggccat      300

gtgttcggcg gagggaccaa gctgaccgtc ctaggtcagc ccaaggctgc cccctcggtc      360

actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcttgga aagcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc a               651


<210>  83
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S71_ Sc3_2C6_VLCL2 aPDL1 IGLV2-23-AA

<400>  83

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Phe Arg Pro 
            20                  25                  30          


Pro Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Phe Ala Ser Leu Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Gln Ser 
                85                  90                  95      


Gly Asp Gly His Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu 
        115                 120         


<210>  84
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S71_ Sc3_2C6_VLCL2 aPDL1 IGLV2-23-NT

<400>  84
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttttt aggcctcctc ttgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tattttgcta gtcttcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatggg atcagtccgg ggacggccat      300

gtgttcggcg gagggaccaa gctgaccgtc ctaggtcagc ccaaggctgc cccctcggtc      360

actctg                                                                 366


<210>  85
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S79_ Sc3_1G7_VLCL2 aPDL1 IGLV2-23-AA

<400>  85

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Phe Arg Pro 
            20                  25                  30          


Pro Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Phe Ala Ser Leu Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp His Thr 
                85                  90                  95      


Gly Asp Gly His Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  86
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S79_ Sc3_1G7_VLCL2 aPDL1 IGLV2-23-NT

<400>  86
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttttt aggcctcctc ttgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tattttgcta gtcttcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatggg atcacacggg cgatgggcat      300

gtcttcggcg gagggaccaa gctgaccgtc ctaggtcagc ccaaggctgc cccctcggtc      360

actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcttgga aagcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc a               651


<210>  87
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S79_ Sc3_1G7_VLCL2 aPDL1 IGLV2-23-AA

<400>  87

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Phe Arg Pro 
            20                  25                  30          


Pro Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Phe Ala Ser Leu Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp His Thr 
                85                  90                  95      


Gly Asp Gly His Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu 
        115                 120         


<210>  88
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S79_ Sc3_1G7_VLCL2 aPDL1 IGLV2-23-NT

<400>  88
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttttt aggcctcctc ttgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tattttgcta gtcttcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatggg atcacacggg cgatgggcat      300

gtcttcggcg gagggaccaa gctgaccgtc ctaggtcagc ccaaggctgc cccctcggtc      360

actctg                                                                 366


<210>  89
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD47-CDRL1

<400>  89

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  90
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S93 IgG_Sa2_1F9-NT

<400>  90
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgtgttt ctactagcga tcatatcgct cataagcctg taaactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat catgatacct ctcgtcctga tggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gcatgggatt tcgcgacgtg gccggctact      300

gaggtgttcg gcggagggac caagctgacc gtcctaggtc agcccaaggc tgccccctcg      360

gtcactctgt tcccgccctc ctctgaggag cttcaagcca acaaggccac actggtgtgt      420

ctcataagtg acttctaccc gggagccgtg acagtggctt ggaaagcaga tagcagcccc      480

gtcaaggcgg gagtggagac caccacaccc tccaaacaaa gcaacaacaa gtacgcggcc      540

agcagctatc tgagcctgac gcctgagcag tggaagtccc acagaagcta cagctgccag      600

gtcacgcatg aagggagcac cgtggagaag acagtggccc ctacagaatg ttcataa         657


<210>  91
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S93 IgG_Sa2_1F9-AA

<400>  91

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Val Ser Thr Ser Asp His Ile Ala His Lys 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr His Asp Thr Ser Arg Pro Asp Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Phe Ala Thr 
                85                  90                  95      


Trp Pro Ala Thr Glu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu 
        115                 120             


<210>  92
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD47-CDRL2

<400>  92

Ala Ala Ser 
1           


<210>  93
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S96 IgG_Sa2_H10-AA

<400>  93

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Asn Leu Pro Ser Ala Asp Ile Ala His Lys 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr His Asp Thr Ser Val Val Thr Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Phe Ala Thr 
                85                  90                  95      


Trp Pro Ala Thr Glu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
        115                 120                 125             


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
    130                 135                 140                 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
145                 150                 155                 160 


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
                165                 170                 175     


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
            180                 185                 190         


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
        195                 200                 205             


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215             


<210>  94
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S96 IgG_Sa2_H10-NT

<400>  94
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcagg gatagttttg taaactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat gctacgaata ttcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gcatggcacc cgtattacac gttgttcggc      300

ggagggacca agctgaccgt cctaggtcag cccaaggctg ccccctcggt cactctgttc      360

ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      420

ttctacccgg gagccgtgac agtggcttgg aaagcagata gcagccccgt caaggcggga      480

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctatctg      540

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      600

gggagcaccg tggagaagac agtggcccct acagaatgtt ca                         642


<210>  95
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S96 IgG_Sa2_H10-AA

<400>  95

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Asn Leu Pro Ser Ala Asp Ile Ala His Lys 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr His Asp Thr Ser Val Val Thr Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Phe Ala Thr 
                85                  90                  95      


Trp Pro Ala Thr Glu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu 
        115                 120             


<210>  96
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD47-CDRL3

<400>  96

Gln Gln Met His Pro Arg Ala Pro Lys Thr 
1               5                   10  


<210>  97
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1-CDRL3-7

<400>  97

Ala Ala Trp Asp Phe Ala Thr Trp Pro Ala Thr Glu Val 
1               5                   10              


<210>  98
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1-CDRL3-8

<400>  98

Ala Ala Trp Asp Phe Ser Arg Trp Pro Ala Thr Glu Val 
1               5                   10              


<210>  99
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S100 IgG_Sa2_1E5-AA

<400>  99

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Glu Asn Lys 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr His Asp Thr Thr Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Phe Ala Thr 
                85                  90                  95      


Trp Pro Ala Thr Glu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu 
        115                 120             


<210>  100
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S100 IgG_Sa2_1E5-NT

<400>  100
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgag aataagcctg taaactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat catgatacta ctcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gcatgggatt tcgcgacgtg gccggctact      300

gaggtgttcg gcggagggac caagctgacc gtcctaggtc agcccaaggc tgccccctcg      360

gtcactctg                                                              369


<210>  101
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1-CDRL1-8

<400>  101

Ser Asp His Ile Ala His Lys Pro 
1               5               


<210>  102
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1-CDRL1-9

<400>  102

Ser Ala Asp Ile Ala His Lys Pro 
1               5               


<210>  103
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1-CDRL1-10

<400>  103

Ser Ser Asn Ile Glu Asn Lys Pro 
1               5               


<210>  104
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  K2_KA3 VKCK aCD47 IGKV1-39-NT

<400>  104
atgagtgtgc ccactcaggt cctggggttg ctgctgctgt ggcttacaga tgccagatgt       60

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      180

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      240

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      300

gaagattttg caacttacta ctgtcagcag atgcacccgc gcgccccgaa gaccttcggc      360

caagggacca aggtggaaat caaacgtacg gtggctgcac catctgtctt catcttcccg      420

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgttaa                   708


<210>  105
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K2_KA3 VKCK aCD47 IGKV1-39-AA

<400>  105

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Met His Pro Arg Ala Pro 
                85                  90                  95      


Lys Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  106
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  K2_KA3 VKCK aCD47 IGKV1-39-NT

<400>  106
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcagcag atgcacccgc gcgccccgaa gaccttcggc      300

caagggacca aggtggaaat caaa                                             324


<210>  107
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K2_KA3 VKCK aCD47 IGKV1-39-AA

<400>  107

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Met His Pro Arg Ala Pro 
                85                  90                  95      


Lys Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  108
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S93 IgG_Sa2_1F9-AA

<400>  108

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Val Ser Thr Ser Asp His Ile Ala His Lys 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr His Asp Thr Ser Arg Pro Asp Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Phe Ala Thr 
                85                  90                  95      


Trp Pro Ala Thr Glu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
        115                 120                 125             


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
    130                 135                 140                 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
145                 150                 155                 160 


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
                165                 170                 175     


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
            180                 185                 190         


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
        195                 200                 205             


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215             


<210>  109
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S93 IgG_Sa2_1F9-NT

<400>  109
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgtgttt ctactagcga tcatatcgct cataagcctg taaactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat catgatacct ctcgtcctga tggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gcatgggatt tcgcgacgtg gccggctact      300

gaggtgttcg gcggagggac caagctgacc gtcctaggtc agcccaaggc tgccccctcg      360

gtcactctg                                                              369


<210>  110
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S96 IgG_Sa2_H10-NT

<400>  110
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcagg gatagttttg taaactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat gctacgaata ttcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gcatggcacc cgtattacac gttgttcggc      300

ggagggacca agctgaccgt cctaggtcag cccaaggctg ccccctcggt cactctg         357


<210>  111
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Dummy-LC1-NT

<400>  111
cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcagctc caatattgag actggttctg tatcctggta ccagcagctc      120

ccaggaacag cccccaaact cctcatttat gacaataata agcgaccctc agggattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tgggcatcac cggactccag      240

actggggacg aggccgatta ttactgcgga acatgggatg acagcctgcc tggatgggtg      300

ttcggcggag ggaccaagct gaccgtccta ggtcagccca aggctgcccc ctcggtcact      360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      420

agtgacttct acccgggagc cgtgacagtg gcttggaaag cagatagcag ccccgtcaag      480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      540

tatctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttcata a               651


<210>  112
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dummy-LC1-AA

<400>  112

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Glu Thr Gly 
            20                  25                  30          


Ser Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asp Ser Leu 
                85                  90                  95      


Pro Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  113
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S100 IgG_Sa2_1E5-AA

<400>  113

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Glu Asn Lys 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr His Asp Thr Thr Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Phe Ala Thr 
                85                  90                  95      


Trp Pro Ala Thr Glu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
        115                 120                 125             


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
    130                 135                 140                 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
145                 150                 155                 160 


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
                165                 170                 175     


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
            180                 185                 190         


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
        195                 200                 205             


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215             


<210>  114
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S100 IgG_Sa2_1E5-NT

<400>  114
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgag aataagcctg taaactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat catgatacta ctcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gcatgggatt tcgcgacgtg gccggctact      300

gaggtgttcg gcggagggac caagctgacc gtcctaggtc agcccaaggc tgccccctcg      360

gtcactctgt tcccgccctc ctctgaggag cttcaagcca acaaggccac actggtgtgt      420

ctcataagtg acttctaccc gggagccgtg acagtggctt ggaaagcaga tagcagcccc      480

gtcaaggcgg gagtggagac caccacaccc tccaaacaaa gcaacaacaa gtacgcggcc      540

agcagctatc tgagcctgac gcctgagcag tggaagtccc acagaagcta cagctgccag      600

gtcacgcatg aagggagcac cgtggagaag acagtggccc ctacagaatg ttcataa         657


<210>  115

<400>  115
000

<210>  116

<400>  116
000

<210>  117

<400>  117
000

<210>  118

<400>  118
000

<210>  119

<400>  119
000

<210>  120

<400>  120
000

<210>  121

<400>  121
000

<210>  122

<400>  122
000

<210>  123

<400>  123
000

<210>  124

<400>  124
000

<210>  125

<400>  125
000

<210>  126

<400>  126
000

<210>  127

<400>  127
000

<210>  128

<400>  128
000

<210>  129

<400>  129
000

<210>  130

<400>  130
000

<210>  131

<400>  131
000

<210>  132

<400>  132
000

<210>  133

<400>  133
000

<210>  134

<400>  134
000

<210>  135

<400>  135
000

<210>  136

<400>  136
000

<210>  137

<400>  137
000

<210>  138

<400>  138
000

<210>  139

<400>  139
000

<210>  140

<400>  140
000

<210>  141

<400>  141
000

<210>  142

<400>  142
000

<210>  143

<400>  143
000

<210>  144

<400>  144
000

<210>  145

<400>  145
000

<210>  146

<400>  146
000

<210>  147

<400>  147
000

<210>  148

<400>  148
000

<210>  149

<400>  149
000

<210>  150

<400>  150
000

<210>  151

<400>  151
000

<210>  152

<400>  152
000

<210>  153

<400>  153
000

<210>  154

<400>  154
000

<210>  155

<400>  155
000

<210>  156

<400>  156
000

<210>  157

<400>  157
000

<210>  158

<400>  158
000

<210>  159

<400>  159
000

<210>  160

<400>  160
000

<210>  161

<400>  161
000

<210>  162

<400>  162
000

<210>  163

<400>  163
000

<210>  164

<400>  164
000

<210>  165

<400>  165
000

<210>  166

<400>  166
000

<210>  167

<400>  167
000

<210>  168

<400>  168
000

<210>  169

<400>  169
000

<210>  170

<400>  170
000

<210>  171

<400>  171
000

<210>  172

<400>  172
000

<210>  173

<400>  173
000

<210>  174

<400>  174
000

<210>  175

<400>  175
000

<210>  176

<400>  176
000

<210>  177

<400>  177
000

<210>  178

<400>  178
000

<210>  179

<400>  179
000

<210>  180

<400>  180
000

<210>  181

<400>  181
000

<210>  182

<400>  182
000

<210>  183

<400>  183
000

<210>  184

<400>  184
000

<210>  185

<400>  185
000

<210>  186

<400>  186
000

<210>  187

<400>  187
000

<210>  188

<400>  188
000

<210>  189

<400>  189
000

<210>  190

<400>  190
000

<210>  191

<400>  191
000

<210>  192

<400>  192
000

<210>  193

<400>  193
000

<210>  194

<400>  194
000

<210>  195

<400>  195
000

<210>  196

<400>  196
000

<210>  197

<400>  197
000

<210>  198

<400>  198
000

<210>  199

<400>  199
000

<210>  200

<400>  200
000

<210>  201

<400>  201
000

<210>  202

<400>  202
000

<210>  203

<400>  203
000

<210>  204

<400>  204
000

<210>  205
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Dummy-VL1-NT

<400>  205
cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcagctc caatattgag actggttctg tatcctggta ccagcagctc      120

ccaggaacag cccccaaact cctcatttat gacaataata agcgaccctc agggattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tgggcatcac cggactccag      240

actggggacg aggccgatta ttactgcgga acatgggatg acagcctgcc tggatgggtg      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210>  206
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dummy-VL1-AA

<400>  206

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Glu Thr Gly 
            20                  25                  30          


Ser Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asp Ser Leu 
                85                  90                  95      


Pro Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  207
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DUMMY-LC2-NT

<400>  207
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gacggttaag aataatttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag tataacaact ggttgcccat caacccctat      300

accttcggcc aagggaccaa ggtggaaatc aaacgtacgg tggctgcacc atctgtcttc      360

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      420

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg      480

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc      540

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc      600

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgttaa         657


<210>  208
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DUMMY-LC2-AA

<400>  208

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Lys Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Leu Pro 
                85                  90                  95      


Ile Asn Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  209
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DUMMY-VL2-NT

<400>  209
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gacggttaag aataatttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag tataacaact ggttgcccat caacccctat      300

accttcggcc aagggaccaa ggtggaaatc aaa                                   333


<210>  210
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DUMMY-VL2-AA

<400>  210

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Lys Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Leu Pro 
                85                  90                  95      


Ile Asn Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


