                         SEQUENCE LISTING

<110>  Georg-August-Universitt Gttingen Stiftung ffentlichen 
       Rechts
 
<120>  Inhibiting protein activity by mimicking a regulatory redox 
       switch

<130>  30A-155 160

<150>  EP21164101.4
<151>  2021-03-22

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  306
<212>  PRT
<213>  coronavirus SARS-CoV2

<400>  1

Ser Gly Phe Arg Lys Met Ala Phe Pro Ser Gly Lys Val Glu Gly Cys 
1               5                   10                  15      


Met Val Gln Val Thr Cys Gly Thr Thr Thr Leu Asn Gly Leu Trp Leu 
            20                  25                  30          


Asp Asp Val Val Tyr Cys Pro Arg His Val Ile Cys Thr Ser Glu Asp 
        35                  40                  45              


Met Leu Asn Pro Asn Tyr Glu Asp Leu Leu Ile Arg Lys Ser Asn His 
    50                  55                  60                  


Asn Phe Leu Val Gln Ala Gly Asn Val Gln Leu Arg Val Ile Gly His 
65                  70                  75                  80  


Ser Met Gln Asn Cys Val Leu Lys Leu Lys Val Asp Thr Ala Asn Pro 
                85                  90                  95      


Lys Thr Pro Lys Tyr Lys Phe Val Arg Ile Gln Pro Gly Gln Thr Phe 
            100                 105                 110         


Ser Val Leu Ala Cys Tyr Asn Gly Ser Pro Ser Gly Val Tyr Gln Cys 
        115                 120                 125             


Ala Met Arg Pro Asn Phe Thr Ile Lys Gly Ser Phe Leu Asn Gly Ser 
    130                 135                 140                 


Cys Gly Ser Val Gly Phe Asn Ile Asp Tyr Asp Cys Val Ser Phe Cys 
145                 150                 155                 160 


Tyr Met His His Met Glu Leu Pro Thr Gly Val His Ala Gly Thr Asp 
                165                 170                 175     


Leu Glu Gly Asn Phe Tyr Gly Pro Phe Val Asp Arg Gln Thr Ala Gln 
            180                 185                 190         


Ala Ala Gly Thr Asp Thr Thr Ile Thr Val Asn Val Leu Ala Trp Leu 
        195                 200                 205             


Tyr Ala Ala Val Ile Asn Gly Asp Arg Trp Phe Leu Asn Arg Phe Thr 
    210                 215                 220                 


Thr Thr Leu Asn Asp Phe Asn Leu Val Ala Met Lys Tyr Asn Tyr Glu 
225                 230                 235                 240 


Pro Leu Thr Gln Asp His Val Asp Ile Leu Gly Pro Leu Ser Ala Gln 
                245                 250                 255     


Thr Gly Ile Ala Val Leu Asp Met Cys Ala Ser Leu Lys Glu Leu Leu 
            260                 265                 270         


Gln Asn Gly Met Asn Gly Arg Thr Ile Leu Gly Ser Ala Leu Leu Glu 
        275                 280                 285             


Asp Glu Phe Thr Pro Phe Asp Val Val Arg Gln Cys Ser Gly Val Thr 
    290                 295                 300                 


Phe Gln 
305     


<210>  2
<211>  306
<212>  PRT
<213>  coronavirus SARS-CoV

<400>  2

Ser Gly Phe Arg Lys Met Ala Phe Pro Ser Gly Lys Val Glu Gly Cys 
1               5                   10                  15      


Met Val Gln Val Thr Cys Gly Thr Thr Thr Leu Asn Gly Leu Trp Leu 
            20                  25                  30          


Asp Asp Thr Val Tyr Cys Pro Arg His Val Ile Cys Thr Ala Glu Asp 
        35                  40                  45              


Met Leu Asn Pro Asn Tyr Glu Asp Leu Leu Ile Arg Lys Ser Asn His 
    50                  55                  60                  


Ser Phe Leu Val Gln Ala Gly Asn Val Gln Leu Arg Val Ile Gly His 
65                  70                  75                  80  


Ser Met Gln Asn Cys Leu Leu Arg Leu Lys Val Asp Thr Ser Asn Pro 
                85                  90                  95      


Lys Thr Pro Lys Tyr Lys Phe Val Arg Ile Gln Pro Gly Gln Thr Phe 
            100                 105                 110         


Ser Val Leu Ala Cys Tyr Asn Gly Ser Pro Ser Gly Val Tyr Gln Cys 
        115                 120                 125             


Ala Met Arg Pro Asn His Thr Ile Lys Gly Ser Phe Leu Asn Gly Ser 
    130                 135                 140                 


Cys Gly Ser Val Gly Phe Asn Ile Asp Tyr Asp Cys Val Ser Phe Cys 
145                 150                 155                 160 


Tyr Met His His Met Glu Leu Pro Thr Gly Val His Ala Gly Thr Asp 
                165                 170                 175     


Leu Glu Gly Lys Phe Tyr Gly Pro Phe Val Asp Arg Gln Thr Ala Gln 
            180                 185                 190         


Ala Ala Gly Thr Asp Thr Thr Ile Thr Leu Asn Val Leu Ala Trp Leu 
        195                 200                 205             


Tyr Ala Ala Val Ile Asn Gly Asp Arg Trp Phe Leu Asn Arg Phe Thr 
    210                 215                 220                 


Thr Thr Leu Asn Asp Phe Asn Leu Val Ala Met Lys Tyr Asn Tyr Glu 
225                 230                 235                 240 


Pro Leu Thr Gln Asp His Val Asp Ile Leu Gly Pro Leu Ser Ala Gln 
                245                 250                 255     


Thr Gly Ile Ala Val Leu Asp Met Cys Ala Ala Leu Lys Glu Leu Leu 
            260                 265                 270         


Gln Asn Gly Met Asn Gly Arg Thr Ile Leu Gly Ser Thr Ile Leu Glu 
        275                 280                 285             


Asp Glu Phe Thr Pro Phe Asp Val Val Arg Gln Cys Ser Gly Val Thr 
    290                 295                 300                 


Phe Gln 
305     


<210>  3
<211>  351
<212>  PRT
<213>  Neisseria gonorrhoeae

<400>  3

Met Thr Ile Leu Ser Asp Val Lys Ala Leu Gly Gln Gln Ile Trp Leu 
1               5                   10                  15      


Asp Asn Leu Ser Arg Ser Leu Val Gln Ser Gly Glu Leu Ala Gln Met 
            20                  25                  30          


Leu Lys Gln Gly Val Cys Gly Val Thr Ser Asn Pro Ala Ile Phe Gln 
        35                  40                  45              


Lys Ala Phe Ala Gly Asp Ala Leu Tyr Ala Asp Glu Val Ala Ala Leu 
    50                  55                  60                  


Lys Arg Gln Asn Leu Ser Pro Lys Gln Arg Tyr Glu Thr Met Ala Val 
65                  70                  75                  80  


Ala Asp Val Arg Ala Ala Cys Asp Val Cys Leu Ala Glu His Glu Ser 
                85                  90                  95      


Thr Gly Gly Lys Thr Gly Phe Val Ser Leu Glu Val Ser Pro Glu Leu 
            100                 105                 110         


Ala Lys Asp Ala Gln Gly Thr Val Glu Glu Ala Arg Arg Leu His Ala 
        115                 120                 125             


Ala Ile Ala Arg Lys Asn Ala Met Ile Lys Val Pro Ala Thr Asp Ala 
    130                 135                 140                 


Gly Ile Asp Ala Leu Glu Thr Leu Val Ser Asp Gly Ile Ser Val Asn 
145                 150                 155                 160 


Leu Thr Leu Leu Phe Ser Arg Ala Gln Thr Leu Lys Ala Tyr Ala Ala 
                165                 170                 175     


Tyr Ala Arg Gly Ile Ala Lys Arg Leu Ala Ala Gly Gln Ser Val Ala 
            180                 185                 190         


His Ile Gln Val Val Ala Ser Phe Phe Ile Ser Arg Val Asp Ser Ala 
        195                 200                 205             


Leu Asp Ala Thr Leu Pro Asp Arg Leu Lys Gly Lys Thr Ala Ile Ala 
    210                 215                 220                 


Leu Ala Lys Ala Ala Tyr Gln Asp Trp Glu Gln Tyr Phe Thr Ala Pro 
225                 230                 235                 240 


Glu Phe Ala Ala Leu Glu Ala Gln Gly Ala Asn Arg Val Gln Leu Leu 
                245                 250                 255     


Trp Ala Ser Thr Gly Val Lys Asn Pro Ala Tyr Pro Asp Thr Leu Tyr 
            260                 265                 270         


Val Asp Ser Leu Ile Gly Val His Thr Val Asn Thr Val Pro Asp Ala 
        275                 280                 285             


Thr Leu Lys Ala Phe Ile Asp His Gly Thr Ala Lys Ala Thr Leu Thr 
    290                 295                 300                 


Glu Ser Ala Asp Glu Ala Arg Ala Arg Leu Ala Glu Ile Ala Ala Leu 
305                 310                 315                 320 


Gly Ile Asp Val Glu Thr Leu Ala Ala Arg Leu Gln Glu Asp Gly Leu 
                325                 330                 335     


Lys Gln Phe Glu Glu Ala Phe Glu Lys Leu Leu Ala Pro Leu Val 
            340                 345                 350     


<210>  4
<211>  351
<212>  PRT
<213>  Neisseria meningitidis

<400>  4

Met Thr Ile Leu Ser Asp Val Lys Ala Leu Gly Gln Gln Ile Trp Leu 
1               5                   10                  15      


Asp Asn Leu Ser Arg Ser Leu Val Gln Ser Gly Glu Leu Ala Gln Met 
            20                  25                  30          


Leu Lys Gln Gly Val Cys Gly Val Thr Ser Asn Pro Ala Ile Phe Gln 
        35                  40                  45              


Lys Ala Phe Ala Gly Asp Ala Leu Tyr Ala Asp Glu Val Ala Ala Leu 
    50                  55                  60                  


Lys Gln Gln Asp Leu Thr Pro Lys Gln Arg Tyr Glu Thr Met Ala Val 
65                  70                  75                  80  


Ala Asp Val Arg Ala Ala Cys Gly Val Cys Leu Ala Glu His Glu Ser 
                85                  90                  95      


Thr Gly Gly Lys Thr Gly Phe Val Ser Leu Glu Val Ser Pro Glu Leu 
            100                 105                 110         


Ser Lys Asp Ala Gln Gly Thr Val Glu Glu Ala Arg Arg Leu Tyr Ala 
        115                 120                 125             


Ala Ile Gly Cys Lys Asn Ala Met Ile Lys Val Pro Ala Thr Asp Ala 
    130                 135                 140                 


Gly Ile Asp Ala Leu Glu Thr Leu Val Ser Asp Gly Ile Ser Val Asn 
145                 150                 155                 160 


Leu Thr Leu Leu Phe Ser Arg Ala Gln Thr Leu Lys Ala Tyr Ala Ala 
                165                 170                 175     


Tyr Ala Arg Gly Ile Ala Lys Arg Leu Ala Ala Gly Gln Ser Val Ala 
            180                 185                 190         


His Ile His Val Val Ala Ser Phe Phe Ile Ser Arg Val Asp Ser Ala 
        195                 200                 205             


Leu Asp Thr Thr Leu Pro Asp Arg Leu Lys Gly Lys Ile Ala Ile Ala 
    210                 215                 220                 


Leu Ala Lys Ala Ala Tyr Gln Asp Trp Glu Gln Tyr Phe Thr Ala Pro 
225                 230                 235                 240 


Glu Phe Ala Ala Leu Glu Ala Gln Gly Ala Asn Arg Val Gln Leu Leu 
                245                 250                 255     


Trp Ala Ser Thr Gly Val Lys Asn Pro Ala Tyr Pro Asp Thr Leu Tyr 
            260                 265                 270         


Val Asp Ser Leu Ile Gly Ala His Thr Val Asn Thr Val Pro Asp Ala 
        275                 280                 285             


Thr Leu Lys Ala Phe Ile Asp His Gly Thr Ala Lys Ala Thr Leu Thr 
    290                 295                 300                 


Glu Gly Ala Asp Glu Ala Gln Ala Gln Leu Ala Glu Ile Ala Ala Leu 
305                 310                 315                 320 


Gly Ile Asp Val Glu Thr Leu Ala Ala Arg Leu Gln Glu Asp Gly Leu 
                325                 330                 335     


Lys Gln Phe Glu Glu Ala Phe Glu Lys Leu Leu Ala Pro Leu Val 
            340                 345                 350     


<210>  5
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neisseria meningitidis transaldolase with N-terminal G

<400>  5

Gly Met Thr Ile Leu Ser Asp Val Lys Ala Leu Gly Gln Gln Ile Trp 
1               5                   10                  15      


Leu Asp Asn Leu Ser Arg Ser Leu Val Gln Ser Gly Glu Leu Ala Gln 
            20                  25                  30          


Met Leu Lys Gln Gly Val Cys Gly Val Thr Ser Asn Pro Ala Ile Phe 
        35                  40                  45              


Gln Lys Ala Phe Ala Gly Asp Ala Leu Tyr Ala Asp Glu Val Ala Ala 
    50                  55                  60                  


Leu Lys Gln Gln Asp Leu Thr Pro Lys Gln Arg Tyr Glu Thr Met Ala 
65                  70                  75                  80  


Val Ala Asp Val Arg Ala Ala Cys Gly Val Cys Leu Ala Glu His Glu 
                85                  90                  95      


Ser Thr Gly Gly Lys Thr Gly Phe Val Ser Leu Glu Val Ser Pro Glu 
            100                 105                 110         


Leu Ser Lys Asp Ala Gln Gly Thr Val Glu Glu Ala Arg Arg Leu Tyr 
        115                 120                 125             


Ala Ala Ile Gly Cys Lys Asn Ala Met Ile Lys Val Pro Ala Thr Asp 
    130                 135                 140                 


Ala Gly Ile Asp Ala Leu Glu Thr Leu Val Ser Asp Gly Ile Ser Val 
145                 150                 155                 160 


Asn Leu Thr Leu Leu Phe Ser Arg Ala Gln Thr Leu Lys Ala Tyr Ala 
                165                 170                 175     


Ala Tyr Ala Arg Gly Ile Ala Lys Arg Leu Ala Ala Gly Gln Ser Val 
            180                 185                 190         


Ala His Ile His Val Val Ala Ser Phe Phe Ile Ser Arg Val Asp Ser 
        195                 200                 205             


Ala Leu Asp Thr Thr Leu Pro Asp Arg Leu Lys Gly Lys Ile Ala Ile 
    210                 215                 220                 


Ala Leu Ala Lys Ala Ala Tyr Gln Asp Trp Glu Gln Tyr Phe Thr Ala 
225                 230                 235                 240 


Pro Glu Phe Ala Ala Leu Glu Ala Gln Gly Ala Asn Arg Val Gln Leu 
                245                 250                 255     


Leu Trp Ala Ser Thr Gly Val Lys Asn Pro Ala Tyr Pro Asp Thr Leu 
            260                 265                 270         


Tyr Val Asp Ser Leu Ile Gly Ala His Thr Val Asn Thr Val Pro Asp 
        275                 280                 285             


Ala Thr Leu Lys Ala Phe Ile Asp His Gly Thr Ala Lys Ala Thr Leu 
    290                 295                 300                 


Thr Glu Gly Ala Asp Glu Ala Gln Ala Gln Leu Ala Glu Ile Ala Ala 
305                 310                 315                 320 


Leu Gly Ile Asp Val Glu Thr Leu Ala Ala Arg Leu Gln Glu Asp Gly 
                325                 330                 335     


Leu Lys Gln Phe Glu Glu Ala Phe Glu Lys Leu Leu Ala Pro Leu Val 
            340                 345                 350         


<210>  6
<211>  599
<212>  PRT
<213>  Vibrio cholerae

<400>  6

Met Thr Gln Ala Ile Lys Arg Val Gly Val Thr Asp Val Val Leu Arg 
1               5                   10                  15      


Asp Ala His Gln Ser Leu Phe Ala Thr Arg Leu Arg Ile Asp Asp Met 
            20                  25                  30          


Leu Pro Ile Ala Gln Gln Leu Asp Gln Ile Gly Tyr Trp Ser Leu Glu 
        35                  40                  45              


Cys Trp Gly Gly Ala Thr Phe Asp Ser Cys Ile Arg Phe Leu Gly Glu 
    50                  55                  60                  


Asp Pro Trp Gln Arg Leu Arg Leu Leu Lys Gln Ala Met Pro Asn Thr 
65                  70                  75                  80  


Pro Leu Gln Met Leu Leu Arg Gly Gln Asn Leu Leu Gly Tyr Arg His 
                85                  90                  95      


Tyr Ala Asp Asp Val Val Asp Thr Phe Val Glu Arg Ala Val Lys Asn 
            100                 105                 110         


Gly Met Asp Val Phe Arg Val Phe Asp Ala Met Asn Asp Val Arg Asn 
        115                 120                 125             


Met Gln Gln Ala Leu Gln Ala Val Lys Lys Met Gly Ala His Ala Gln 
    130                 135                 140                 


Gly Thr Leu Cys Tyr Thr Thr Ser Pro Val His Asn Leu Gln Thr Trp 
145                 150                 155                 160 


Val Asp Val Ala Gln Gln Leu Ala Glu Leu Gly Val Asp Ser Ile Ala 
                165                 170                 175     


Leu Lys Asp Met Ala Gly Ile Leu Thr Pro Tyr Ala Ala Glu Glu Leu 
            180                 185                 190         


Val Ser Thr Leu Lys Lys Gln Val Asp Val Glu Leu His Leu His Cys 
        195                 200                 205             


His Ser Thr Ala Gly Leu Ala Asp Met Thr Leu Leu Lys Ala Ile Glu 
    210                 215                 220                 


Ala Gly Val Asp Arg Val Asp Thr Ala Ile Ser Ser Met Ser Gly Thr 
225                 230                 235                 240 


Tyr Gly His Pro Ala Thr Glu Ser Leu Val Ala Thr Leu Gln Gly Thr 
                245                 250                 255     


Gly Tyr Asp Thr Gly Leu Asp Ile Ala Lys Leu Glu Gln Ile Ala Ala 
            260                 265                 270         


Tyr Phe Arg Asp Val Arg Lys Lys Tyr His Ala Phe Glu Gly Met Met 
        275                 280                 285             


Lys Gly Ser Asp Ala Arg Ile Leu Val Ala Gln Val Pro Gly Gly Met 
    290                 295                 300                 


Leu Thr Asn Met Glu Ser Gln Leu Lys Gln Gln Asn Ala Leu Asp Lys 
305                 310                 315                 320 


Leu Asp Leu Val Leu Glu Glu Ile Pro Arg Val Arg Glu Glu Leu Gly 
                325                 330                 335     


Phe Leu Pro Leu Val Thr Pro Thr Ser Gln Ile Val Gly Thr Gln Ala 
            340                 345                 350         


Val Ile Asn Val Val Leu Gly Glu Arg Tyr Lys Thr Ile Thr Lys Glu 
        355                 360                 365             


Thr Ser Gly Val Leu Lys Gly Glu Tyr Gly Lys Thr Pro Ala Pro Val 
    370                 375                 380                 


Asn Thr Glu Leu Gln Ala Arg Val Leu Ala Gly Ala Glu Ala Ile Thr 
385                 390                 395                 400 


Cys Arg Pro Ala Asp Leu Ile Ala Ala Glu Met Pro Thr Leu Gln Asp 
                405                 410                 415     


Arg Val Leu Gln Gln Ala Lys Glu Gln His Ile Thr Leu Ala Glu Asn 
            420                 425                 430         


Ala Ile Asp Asp Val Leu Thr Ile Ala Leu Phe Asp Gln Val Gly Trp 
        435                 440                 445             


Lys Phe Leu Ala Asn Arg His Asn Pro Glu Ala Phe Glu Pro Ala Pro 
    450                 455                 460                 


Gln Ala Ile Ser Ser Ala Cys Thr Pro Lys Ala Pro Thr Glu Lys Ser 
465                 470                 475                 480 


Lys Val Gln Pro Val Glu Ser His Gly Val Tyr Thr Ile Thr Val Asn 
                485                 490                 495     


Asn Gln Ser Tyr Val Val Lys Val Asp Glu Gly Gly Asp Leu Thr His 
            500                 505                 510         


Val Ala Pro Thr Ala Ser Thr Asn His Ala Pro Val Pro Ser Ala Ala 
        515                 520                 525             


Glu Gly Glu Asn Leu Ala Ala Pro Leu Ser Gly Asn Ile Trp Lys Ile 
    530                 535                 540                 


His Ala Ser Ala Gly Asp Glu Val Ala Glu Gly Asp Val Leu Leu Ile 
545                 550                 555                 560 


Leu Glu Ala Met Lys Met Glu Thr Glu Ile Arg Ala Pro Arg Ala Gly 
                565                 570                 575     


Val Ile Ser Ala Ile Glu Val Asn Glu Gly Asp Ala Val Gln Val Gly 
            580                 585                 590         


Asp Ala Leu Leu Val Leu Ala 
        595                 


<210>  7
<211>  1146
<212>  PRT
<213>  Listeria monocytogenes

<400>  7

Met Asn Arg Ile Lys Lys Val Leu Val Ala Asn Arg Gly Glu Ile Ala 
1               5                   10                  15      


Ile Arg Val Met Arg Ala Cys Thr Glu Leu Lys Ile Lys Thr Val Ala 
            20                  25                  30          


Ile Tyr Ser Gln Glu Asp Thr Gly Ser Phe His Arg Tyr Lys Ser Asp 
        35                  40                  45              


Glu Ala Tyr Leu Val Gly Ala Gly Lys Lys Pro Ile Asp Ala Tyr Leu 
    50                  55                  60                  


Asp Ile Glu Asn Ile Ile Glu Ile Ala Lys Glu Ser Gly Ala Asp Ala 
65                  70                  75                  80  


Ile His Pro Gly Tyr Gly Phe Leu Ser Glu Asn Ile Glu Phe Ala Arg 
                85                  90                  95      


Arg Cys Glu Gln Glu Gly Ile Ile Phe Val Gly Pro Lys Ser Lys His 
            100                 105                 110         


Leu Asp Met Phe Gly Asp Lys Ile Lys Ala Lys Glu Gln Ala Leu Leu 
        115                 120                 125             


Ala Asp Ile Pro Val Ile Pro Gly Ser Asn Gly Pro Val Ala Gly Ile 
    130                 135                 140                 


Lys Glu Val Glu Glu Phe Gly Glu Lys Asn Gly Tyr Pro Leu Met Ile 
145                 150                 155                 160 


Lys Ala Ser Leu Gly Gly Gly Gly Arg Gly Met Arg Val Val Glu Ser 
                165                 170                 175     


Lys Glu His Val Lys Glu Ser Phe Glu Arg Ala Ser Ser Glu Ala Lys 
            180                 185                 190         


Ala Ala Phe Gly Asn Asp Glu Val Tyr Val Glu Lys Cys Val Met Asn 
        195                 200                 205             


Pro Lys His Ile Glu Val Gln Ile Leu Gly Asp Thr His Gly Asn Ile 
    210                 215                 220                 


Val His Leu Phe Glu Arg Asp Cys Ser Ile Gln Arg Arg His Gln Lys 
225                 230                 235                 240 


Val Val Glu Val Ala Pro Cys Asn Ala Ile Thr Ser Glu Leu Arg Asn 
                245                 250                 255     


Arg Ile Cys Asp Ala Ala Val Lys Leu Met Lys Asn Val Asp Tyr Ile 
            260                 265                 270         


Asn Ala Gly Thr Val Glu Phe Leu Val Glu Gly Asp Asp Phe Tyr Phe 
        275                 280                 285             


Ile Glu Val Asn Pro Arg Val Gln Val Glu His Thr Ile Thr Glu Met 
    290                 295                 300                 


Ile Thr Gly Ile Asp Ile Val Gln Ser Gln Leu Phe Ile Ala Asp Gly 
305                 310                 315                 320 


Tyr Ala Leu His Asp Gln Leu Val Ala Ile Pro Lys Gln Glu Asp Ile 
                325                 330                 335     


His Ile His Gly Ser Ala Ile Gln Ser Arg Ile Thr Thr Glu Asp Pro 
            340                 345                 350         


Leu Asn Asn Phe Met Pro Asp Thr Gly Arg Val Asp Thr Tyr Arg Ser 
        355                 360                 365             


Thr Gly Gly Phe Gly Val Arg Leu Asp Ala Gly Asn Gly Phe Gln Gly 
    370                 375                 380                 


Thr Val Val Thr Pro Phe Tyr Asp Ser Leu Leu Val Lys Leu Cys Thr 
385                 390                 395                 400 


Trp Gly Met Thr Phe Glu Gln Ala Thr Arg Lys Met Arg Arg Asn Leu 
                405                 410                 415     


Ile Glu Phe Arg Ile Arg Gly Val Lys Thr Asn Ile Pro Phe Leu Leu 
            420                 425                 430         


Asn Val Val Arg His Pro Asp Phe Ala Ser Gly Asn Tyr Asn Thr Ser 
        435                 440                 445             


Phe Ile Asp Thr Thr Pro Glu Leu Phe Lys Phe Pro His Ile Arg Asp 
    450                 455                 460                 


Arg Gly Thr Lys Thr Leu Arg Tyr Ile Gly Asn Val Thr Val Asn Gly 
465                 470                 475                 480 


Phe Pro Gly Ile Lys His Arg Asp Lys Pro Val Tyr Ala Glu Pro Arg 
                485                 490                 495     


Leu Pro Lys Ile Pro Tyr Gly Ser Gln Ile Ser Pro Gly Thr Lys Gln 
            500                 505                 510         


Ile Leu Asp Ala Lys Gly Pro Glu Gly Val Val Asp Trp Val Lys Lys 
        515                 520                 525             


Gln Glu Glu Val Leu Leu Thr Asp Thr Thr Leu Arg Asp Ala His Gln 
    530                 535                 540                 


Ser Leu Leu Ala Thr Arg Val Arg Ser Lys Asp Ile Phe Gln Val Ala 
545                 550                 555                 560 


Asp Ala Met Ala His Leu Leu Pro Asn Met Phe Ser Phe Glu Met Trp 
                565                 570                 575     


Gly Gly Ala Thr Phe Asp Val Ala Tyr Arg Phe Leu Asn Glu Asp Pro 
            580                 585                 590         


Trp Val Arg Leu Glu Thr Leu Arg Lys Gln Ile Pro Asn Val Met Phe 
        595                 600                 605             


Gln Met Leu Leu Arg Gly Ala Asn Ala Val Gly Tyr Lys Asn Tyr Pro 
    610                 615                 620                 


Asp Asn Val Ile Arg Glu Phe Val Lys Gln Ser Ala Gln Ser Gly Val 
625                 630                 635                 640 


Asp Val Phe Arg Val Phe Asp Ser Leu Asn Trp Ile Lys Gly Met Glu 
                645                 650                 655     


Val Ser Ile Asp Ala Val Arg Glu Ala Gly Lys Val Val Glu Ala Ala 
            660                 665                 670         


Ile Cys Tyr Thr Gly Asp Ile Asp Asp Asp Thr Arg Thr Lys Tyr Thr 
        675                 680                 685             


Ile Asp Tyr Tyr Lys Asp Met Ala Lys Glu Leu Val Ala Gln Gly Thr 
    690                 695                 700                 


His Ile Leu Gly Ile Lys Asp Met Ala Gly Leu Leu Lys Pro Gln Ala 
705                 710                 715                 720 


Ala Tyr Arg Leu Ile Gly Glu Leu Lys Asp Thr Val Asp Val Pro Ile 
                725                 730                 735     


His Leu His Thr His Asp Thr Ser Gly Asn Gly Ile Tyr Thr Tyr Ala 
            740                 745                 750         


Ala Ala Val Ser Ala Gly Val Asp Ile Val Asp Val Ala Ser Ser Ala 
        755                 760                 765             


Met Ser Gly Ala Thr Ser Gln Pro Ser Met Thr Gly Leu Tyr Tyr Gly 
    770                 775                 780                 


Leu Val Asn Gly Asn Arg Gln Thr Asn Leu Asp Ala Gln Asn Ser Gln 
785                 790                 795                 800 


Ile Ile Asn His Tyr Trp Glu Asp Val Arg His Tyr Tyr Lys Asp Phe 
                805                 810                 815     


Asp Asn Ala Leu Asn Ser Pro Gln Thr Glu Val Tyr Ile His Glu Met 
            820                 825                 830         


Pro Gly Gly Gln Tyr Thr Asn Leu Gln Gln Gln Ala Ile Ala Val Gly 
        835                 840                 845             


Leu Gly Asp Arg Trp Asp Glu Val Lys Glu Met Tyr Thr Val Val Asn 
    850                 855                 860                 


Gln Met Phe Gly Asp Ile Val Lys Val Thr Pro Ser Ser Lys Val Val 
865                 870                 875                 880 


Gly Asp Leu Ala Leu Phe Met Val Gln Asn Glu Leu Ser Glu Glu Asp 
                885                 890                 895     


Val Tyr Glu Lys Gly Asp Thr Ile Asp Phe Pro Asp Ser Val Ile Glu 
            900                 905                 910         


Phe Phe Met Gly Glu Ile Gly Gln Pro Tyr Gly Gly Phe Pro Glu Lys 
        915                 920                 925             


Leu Gln Lys Leu Val Leu Lys Gly Arg Thr Pro Leu Thr Asp Arg Pro 
    930                 935                 940                 


Gly Ala Leu Met Glu Pro Val Asn Phe Val Asp Val Lys Ala Glu Leu 
945                 950                 955                 960 


Lys Glu Lys Met Gly Tyr Glu Pro Thr Glu Lys Asp Val Ile Ser Tyr 
                965                 970                 975     


Ile Leu Tyr Pro Lys Val Phe Leu Asp Tyr Gln Asp Met Ile Asn Lys 
            980                 985                 990         


Tyr Gly Asp Val Thr Val Leu Asp  Thr Pro Thr Phe Tyr  Lys Gly Met 
        995                 1000                 1005             


Arg Leu  Gly Glu Thr Ile Glu  Val Glu Leu Glu Lys  Gly Lys Ile 
    1010                 1015                 1020             


Leu Leu  Ile Lys Leu Asn Ser  Ile Gly Glu Pro Ile  Ala Asp Gly 
    1025                 1030                 1035             


Thr Arg  Val Ile Tyr Phe Glu  Leu Asn Gly Gln Pro  Arg Glu Ile 
    1040                 1045                 1050             


Asn Ile  Gln Asp Met Asn Val  Gln Ser Thr Val Ile  Ala Arg Arg 
    1055                 1060                 1065             


Lys Ile  Asp Thr Thr Asn Pro  Glu His Val Gly Ala  Thr Met Thr 
    1070                 1075                 1080             


Gly Ser  Val Ile Gln Val Val  Val Lys Lys Gly Asp  Ser Val Lys 
    1085                 1090                 1095             


Lys Gly  Asp Pro Leu Leu Ile  Thr Glu Ala Met Lys  Met Glu Thr 
    1100                 1105                 1110             


Thr Ile  Gln Ala Pro Phe Asp  Gly Glu Val Ser Ser  Ile Tyr Val 
    1115                 1120                 1125             


Ser Asp  Gly Asp Thr Ile Glu  Ser Gly Asp Leu Leu  Ile Glu Val 
    1130                 1135                 1140             


Asn Arg  Ile 
    1145     


<210>  8
<211>  1150
<212>  PRT
<213>  Staphylococcus aureus

<400>  8

Met Lys Gln Ile Lys Lys Leu Leu Val Ala Asn Arg Gly Glu Ile Ala 
1               5                   10                  15      


Ile Arg Ile Phe Arg Ala Ala Ala Glu Leu Asp Ile Ser Thr Val Ala 
            20                  25                  30          


Ile Tyr Ser Asn Glu Asp Lys Ser Ser Leu His Arg Tyr Lys Ala Asp 
        35                  40                  45              


Glu Ser Tyr Leu Val Gly Ser Asp Leu Gly Pro Ala Glu Ser Tyr Leu 
    50                  55                  60                  


Asn Ile Glu Arg Ile Ile Asp Val Ala Lys Gln Ala Asn Val Asp Ala 
65                  70                  75                  80  


Ile His Pro Gly Tyr Gly Phe Leu Ser Glu Asn Glu Gln Phe Ala Arg 
                85                  90                  95      


Arg Cys Ala Glu Glu Gly Ile Lys Phe Ile Gly Pro His Leu Glu His 
            100                 105                 110         


Leu Asp Met Phe Gly Asp Lys Val Lys Ala Arg Thr Thr Ala Ile Lys 
        115                 120                 125             


Ala Asp Leu Pro Val Ile Pro Gly Thr Asp Gly Pro Ile Lys Ser Tyr 
    130                 135                 140                 


Glu Leu Ala Lys Glu Phe Ala Glu Glu Ala Gly Phe Pro Leu Met Ile 
145                 150                 155                 160 


Lys Ala Thr Ser Gly Gly Gly Gly Lys Gly Met Arg Ile Val Arg Glu 
                165                 170                 175     


Glu Ser Glu Leu Glu Asp Ala Phe His Arg Ala Lys Ser Glu Ala Glu 
            180                 185                 190         


Lys Ser Phe Gly Asn Ser Glu Val Tyr Ile Glu Arg Tyr Ile Asp Asn 
        195                 200                 205             


Pro Lys His Ile Glu Val Gln Val Ile Gly Asp Glu His Gly Asn Ile 
    210                 215                 220                 


Val His Leu Phe Glu Arg Asp Cys Ser Val Gln Arg Arg His Gln Lys 
225                 230                 235                 240 


Val Val Glu Val Ala Pro Ser Val Gly Leu Ser Pro Thr Leu Arg Gln 
                245                 250                 255     


Arg Ile Cys Asp Ala Ala Ile Gln Leu Met Glu Asn Ile Lys Tyr Val 
            260                 265                 270         


Asn Ala Gly Thr Val Glu Phe Leu Val Ser Gly Asp Glu Phe Phe Phe 
        275                 280                 285             


Ile Glu Val Asn Pro Arg Val Gln Val Glu His Thr Ile Thr Glu Met 
    290                 295                 300                 


Val Thr Gly Ile Asp Ile Val Lys Thr Gln Ile Leu Val Ala Ala Gly 
305                 310                 315                 320 


Ala Asp Leu Phe Gly Glu Glu Ile Asn Met Pro Gln Gln Lys Asp Ile 
                325                 330                 335     


Thr Thr Leu Gly Tyr Ala Ile Gln Cys Arg Ile Thr Thr Glu Asp Pro 
            340                 345                 350         


Leu Asn Asp Phe Met Pro Asp Thr Gly Thr Ile Ile Ala Tyr Arg Ser 
        355                 360                 365             


Ser Gly Gly Phe Gly Val Arg Leu Asp Ala Gly Asp Gly Phe Gln Gly 
    370                 375                 380                 


Ala Glu Ile Ser Pro Tyr Tyr Asp Ser Leu Leu Val Lys Leu Ser Thr 
385                 390                 395                 400 


His Ala Ile Ser Phe Lys Gln Ala Glu Glu Lys Met Val Arg Ser Leu 
                405                 410                 415     


Arg Glu Met Arg Ile Arg Gly Val Lys Thr Asn Ile Pro Phe Leu Ile 
            420                 425                 430         


Asn Val Met Lys Asn Lys Lys Phe Thr Ser Gly Asp Tyr Thr Thr Lys 
        435                 440                 445             


Phe Ile Glu Glu Thr Pro Glu Leu Phe Asp Ile Gln Pro Ser Leu Asp 
    450                 455                 460                 


Arg Gly Thr Lys Thr Leu Glu Tyr Ile Gly Asn Val Thr Ile Asn Gly 
465                 470                 475                 480 


Phe Pro Asn Val Glu Lys Arg Pro Lys Pro Asp Tyr Glu Leu Ala Ser 
                485                 490                 495     


Ile Pro Thr Val Ser Ser Ser Lys Ile Ala Ser Phe Ser Gly Thr Lys 
            500                 505                 510         


Gln Leu Leu Asp Glu Val Gly Pro Lys Gly Val Ala Glu Trp Val Lys 
        515                 520                 525             


Lys Gln Asp Asp Val Leu Leu Thr Asp Thr Thr Phe Arg Asp Ala His 
    530                 535                 540                 


Gln Ser Leu Leu Ala Thr Arg Val Arg Thr Lys Asp Met Ile Asn Ile 
545                 550                 555                 560 


Ala Ser Lys Thr Ala Asp Val Phe Lys Asp Gly Phe Ser Leu Glu Met 
                565                 570                 575     


Trp Gly Gly Ala Thr Phe Asp Val Ala Tyr Asn Phe Leu Lys Glu Asn 
            580                 585                 590         


Pro Trp Glu Arg Leu Glu Arg Leu Arg Lys Ala Ile Pro Asn Val Leu 
        595                 600                 605             


Phe Gln Met Leu Leu Arg Ala Ser Asn Ala Val Gly Tyr Lys Asn Tyr 
    610                 615                 620                 


Pro Asp Asn Val Ile His Lys Phe Val Gln Glu Ser Ala Lys Ala Gly 
625                 630                 635                 640 


Ile Asp Val Phe Arg Ile Phe Asp Ser Leu Asn Trp Val Asp Gln Met 
                645                 650                 655     


Lys Val Ala Asn Glu Ala Val Gln Glu Ala Gly Lys Ile Ser Glu Gly 
            660                 665                 670         


Thr Ile Cys Tyr Thr Gly Asp Ile Leu Asn Pro Glu Arg Ser Asn Ile 
        675                 680                 685             


Tyr Thr Leu Glu Tyr Tyr Val Lys Leu Ala Lys Glu Leu Glu Arg Glu 
    690                 695                 700                 


Gly Phe His Ile Leu Ala Ile Lys Asp Met Ala Gly Leu Leu Lys Pro 
705                 710                 715                 720 


Lys Ala Ala Tyr Glu Leu Ile Gly Glu Leu Lys Ser Ala Val Asp Leu 
                725                 730                 735     


Pro Ile His Leu His Thr His Asp Thr Ser Gly Asn Gly Leu Leu Thr 
            740                 745                 750         


Tyr Lys Gln Ala Ile Asp Ala Gly Val Asp Ile Ile Asp Thr Ala Val 
        755                 760                 765             


Ala Ser Met Ser Gly Leu Thr Ser Gln Pro Ser Ala Asn Ser Leu Tyr 
    770                 775                 780                 


Tyr Ala Leu Asn Gly Phe Pro Arg His Leu Arg Thr Asp Ile Glu Gly 
785                 790                 795                 800 


Met Glu Ser Leu Ser His Tyr Trp Ser Thr Val Arg Thr Tyr Tyr Ser 
                805                 810                 815     


Asp Phe Glu Ser Asp Ile Lys Ser Pro Asn Thr Glu Ile Tyr Gln His 
            820                 825                 830         


Glu Met Pro Gly Gly Gln Tyr Ser Asn Leu Ser Gln Gln Ala Lys Ser 
        835                 840                 845             


Leu Gly Leu Gly Glu Arg Phe Asp Glu Val Lys Asp Met Tyr Arg Arg 
    850                 855                 860                 


Val Asn Phe Leu Phe Gly Asp Ile Val Lys Val Thr Pro Ser Ser Lys 
865                 870                 875                 880 


Val Val Gly Asp Met Ala Leu Tyr Met Val Gln Asn Asp Leu Asp Glu 
                885                 890                 895     


Gln Ser Val Ile Thr Asp Gly Tyr Lys Leu Asp Phe Pro Glu Ser Val 
            900                 905                 910         


Val Ser Phe Phe Lys Gly Glu Ile Gly Gln Pro Val Asn Gly Phe Asn 
        915                 920                 925             


Lys Asp Leu Gln Ala Val Ile Leu Lys Gly Gln Glu Ala Leu Thr Ala 
    930                 935                 940                 


Arg Pro Gly Glu Tyr Leu Glu Pro Val Asp Phe Glu Lys Val Arg Glu 
945                 950                 955                 960 


Leu Leu Glu Glu Glu Gln Gln Gly Pro Val Thr Glu Gln Asp Ile Ile 
                965                 970                 975     


Ser Tyr Val Leu Tyr Pro Lys Val Tyr Glu Gln Tyr Ile Gln Thr Arg 
            980                 985                 990         


Asn Gln Tyr Gly Asn Leu Ser Leu  Leu Asp Thr Pro Thr  Phe Phe Phe 
        995                 1000                 1005             


Gly Met  Arg Asn Gly Glu Thr  Val Glu Ile Glu Ile  Asp Lys Gly 
    1010                 1015                 1020             


Lys Arg  Leu Ile Ile Lys Leu  Glu Thr Ile Ser Glu  Pro Asp Glu 
    1025                 1030                 1035             


Asn Gly  Asn Arg Thr Ile Tyr  Tyr Ala Met Asn Gly  Gln Ala Arg 
    1040                 1045                 1050             


Arg Ile  Tyr Ile Lys Asp Glu  Asn Val His Thr Asn  Ala Asn Val 
    1055                 1060                 1065             


Lys Pro  Lys Ala Asp Lys Ser  Asn Pro Ser His Ile  Gly Ala Gln 
    1070                 1075                 1080             


Met Pro  Gly Ser Val Thr Glu  Val Lys Val Ser Val  Gly Glu Thr 
    1085                 1090                 1095             


Val Lys  Ala Asn Gln Pro Leu  Leu Ile Thr Glu Ala  Met Lys Met 
    1100                 1105                 1110             


Glu Thr  Thr Ile Gln Ala Pro  Phe Asp Gly Val Ile  Lys Gln Val 
    1115                 1120                 1125             


Thr Val  Asn Asn Gly Asp Thr  Ile Ala Thr Gly Asp  Leu Leu Ile 
    1130                 1135                 1140             


Glu Ile  Glu Lys Ala Thr Asp  
    1145                 1150 


<210>  9
<211>  425
<212>  PRT
<213>  Trypanosoma cruzi

<400>  9

Met Thr Ala Phe Ala Cys Phe Pro His Ser Leu Phe Tyr Ser Thr Arg 
1               5                   10                  15      


Leu Pro Phe Phe Phe Phe Phe Phe Cys Val Cys Val His Cys Cys Leu 
            20                  25                  30          


Arg Tyr Leu Cys Leu Leu Lys Cys Ala Tyr Cys Cys Ser Asp Lys Asn 
        35                  40                  45              


Tyr Phe Arg Pro Leu Asn Tyr Phe Phe Tyr Cys Leu Tyr Leu Ala Met 
    50                  55                  60                  


Ala Ser Met Glu Arg Phe Leu Ser Val Tyr Asp Glu Val Gln Ala Phe 
65                  70                  75                  80  


Leu Leu Asp Gln Leu Gln Ser Lys Tyr Glu Ile Asp Pro Asn Arg Ala 
                85                  90                  95      


Arg Tyr Leu Arg Ile Met Met Asp Thr Thr Cys Leu Gly Gly Lys Tyr 
            100                 105                 110         


Phe Arg Gly Met Thr Val Val Asn Val Ala Glu Gly Phe Leu Ala Val 
        115                 120                 125             


Thr Gln His Asp Glu Ala Thr Lys Glu Arg Ile Leu His Asp Ala Cys 
    130                 135                 140                 


Val Gly Gly Trp Met Ile Glu Phe Leu Gln Ala His Tyr Leu Val Glu 
145                 150                 155                 160 


Asp Asp Ile Met Asp Gly Ser Val Met Arg Arg Gly Lys Pro Cys Trp 
                165                 170                 175     


Tyr Arg Phe Pro Gly Val Thr Thr Gln Cys Ala Ile Asn Asp Gly Ile 
            180                 185                 190         


Ile Leu Lys Ser Trp Thr Gln Ile Met Ala Trp His Tyr Phe Ala Asp 
        195                 200                 205             


Arg Pro Phe Leu Lys Asp Leu Leu Cys Leu Phe Gln Lys Val Asp Tyr 
    210                 215                 220                 


Ala Thr Ala Val Gly Gln Met Tyr Asp Val Thr Ser Met Cys Asp Ser 
225                 230                 235                 240 


Asn Lys Leu Asp Pro Glu Val Ala Gln Pro Met Thr Thr Asp Phe Ala 
                245                 250                 255     


Glu Phe Thr Pro Ala Ile Tyr Lys Arg Ile Val Lys Tyr Lys Thr Thr 
            260                 265                 270         


Phe Tyr Thr Tyr Leu Leu Pro Leu Val Met Gly Leu Leu Val Ser Glu 
        275                 280                 285             


Ala Ala Ala Ser Val Glu Met Asn Leu Val Glu Arg Val Ala His Leu 
    290                 295                 300                 


Ile Gly Glu Tyr Phe Gln Val Gln Asp Asp Val Met Asp Cys Phe Thr 
305                 310                 315                 320 


Pro Pro Glu Gln Leu Gly Lys Val Gly Thr Asp Ile Glu Asp Ala Lys 
                325                 330                 335     


Cys Ser Trp Leu Ala Val Thr Phe Leu Gly Lys Ala Asn Ala Ala Gln 
            340                 345                 350         


Val Ala Glu Phe Lys Ala Asn Tyr Gly Glu Lys Asp Pro Ala Lys Val 
        355                 360                 365             


Ala Val Val Lys Arg Leu Tyr Ser Lys Ala Asn Leu Gln Ala Asp Phe 
    370                 375                 380                 


Ala Ala Tyr Glu Ala Glu Val Val Arg Glu Val Glu Ser Leu Ile Glu 
385                 390                 395                 400 


Gln Leu Lys Val Lys Ser Pro Thr Phe Ala Glu Ser Val Ala Val Val 
                405                 410                 415     


Trp Glu Lys Thr His Lys Arg Lys Lys 
            420                 425 


<210>  10
<211>  462
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  10

Met Asn Trp Thr Val Asp Ile Pro Ile Asp Gln Leu Pro Ser Leu Pro 
1               5                   10                  15      


Pro Leu Pro Thr Asp Leu Arg Thr Arg Leu Asp Ala Ala Leu Ala Lys 
            20                  25                  30          


Pro Ala Ala Gln Gln Pro Thr Trp Pro Ala Asp Gln Ala Leu Ala Met 
        35                  40                  45              


Arg Thr Val Leu Glu Ser Val Pro Pro Val Thr Val Pro Ser Glu Ile 
    50                  55                  60                  


Val Arg Leu Gln Glu Gln Leu Ala Gln Val Ala Lys Gly Glu Ala Phe 
65                  70                  75                  80  


Leu Leu Gln Gly Gly Asp Cys Ala Glu Thr Phe Met Asp Asn Thr Glu 
                85                  90                  95      


Pro His Ile Arg Gly Asn Val Arg Ala Leu Leu Gln Met Ala Val Val 
            100                 105                 110         


Leu Thr Tyr Gly Ala Ser Met Pro Val Val Lys Val Ala Arg Ile Ala 
        115                 120                 125             


Gly Gln Tyr Ala Lys Pro Arg Ser Ala Asp Ile Asp Ala Leu Gly Leu 
    130                 135                 140                 


Arg Ser Tyr Arg Gly Asp Met Ile Asn Gly Phe Ala Pro Asp Ala Ala 
145                 150                 155                 160 


Ala Arg Glu His Asp Pro Ser Arg Leu Val Arg Ala Tyr Ala Asn Ala 
                165                 170                 175     


Ser Ala Ala Met Asn Leu Val Arg Ala Leu Thr Ser Ser Gly Leu Ala 
            180                 185                 190         


Ser Leu His Leu Val His Asp Trp Asn Arg Glu Phe Val Arg Thr Ser 
        195                 200                 205             


Pro Ala Gly Ala Arg Tyr Glu Ala Leu Ala Thr Glu Ile Asp Arg Gly 
    210                 215                 220                 


Leu Arg Phe Met Ser Ala Cys Gly Val Ala Asp Arg Asn Leu Gln Thr 
225                 230                 235                 240 


Ala Glu Ile Tyr Ala Ser His Glu Ala Leu Val Leu Asp Tyr Glu Arg 
                245                 250                 255     


Ala Met Leu Arg Leu Ser Asp Gly Asp Asp Gly Glu Pro Gln Leu Phe 
            260                 265                 270         


Asp Leu Ser Ala His Thr Val Trp Ile Gly Glu Arg Thr Arg Gln Ile 
        275                 280                 285             


Asp Gly Ala His Ile Ala Phe Ala Gln Val Ile Ala Asn Pro Val Gly 
    290                 295                 300                 


Val Lys Leu Gly Pro Asn Met Thr Pro Glu Leu Ala Val Glu Tyr Val 
305                 310                 315                 320 


Glu Arg Leu Asp Pro His Asn Lys Pro Gly Arg Leu Thr Leu Val Ser 
                325                 330                 335     


Arg Met Gly Asn His Lys Val Arg Asp Leu Leu Pro Pro Ile Val Glu 
            340                 345                 350         


Lys Val Gln Ala Thr Gly His Gln Val Ile Trp Gln Cys Asp Pro Met 
        355                 360                 365             


His Gly Asn Thr His Glu Ser Ser Thr Gly Phe Lys Thr Arg His Phe 
    370                 375                 380                 


Asp Arg Ile Val Asp Glu Val Gln Gly Phe Phe Glu Val His Arg Ala 
385                 390                 395                 400 


Leu Gly Thr His Pro Gly Gly Ile His Val Glu Ile Thr Gly Glu Asn 
                405                 410                 415     


Val Thr Glu Cys Leu Gly Gly Ala Gln Asp Ile Ser Glu Thr Asp Leu 
            420                 425                 430         


Ala Gly Arg Tyr Glu Thr Ala Cys Asp Pro Arg Leu Asn Thr Gln Gln 
        435                 440                 445             


Ser Leu Glu Leu Ala Phe Leu Val Ala Glu Met Leu Arg Asp 
    450                 455                 460         


<210>  11
<211>  423
<212>  PRT
<213>  Trypanosoma brucei

<400>  11

Met Asp Ile Val Val Asn Asp Asp Leu Ser Cys Arg Phe Leu Glu Gly 
1               5                   10                  15      


Phe Asn Thr Arg Asp Ala Leu Cys Lys Lys Ile Ser Met Asn Thr Cys 
            20                  25                  30          


Asp Glu Gly Asp Pro Phe Phe Val Ala Asp Leu Gly Asp Ile Val Arg 
        35                  40                  45              


Lys His Glu Thr Trp Lys Lys Cys Leu Pro Arg Val Thr Pro Phe Tyr 
    50                  55                  60                  


Ala Val Lys Cys Asn Asp Asp Trp Arg Val Leu Gly Thr Leu Ala Ala 
65                  70                  75                  80  


Leu Gly Thr Gly Phe Asp Cys Ala Ser Asn Thr Glu Ile Gln Arg Val 
                85                  90                  95      


Arg Gly Ile Gly Val Pro Pro Glu Lys Ile Ile Tyr Ala Asn Pro Cys 
            100                 105                 110         


Lys Gln Ile Ser His Ile Arg Tyr Ala Arg Asp Ser Gly Val Asp Val 
        115                 120                 125             


Met Thr Phe Asp Cys Val Asp Glu Leu Glu Lys Val Ala Lys Thr His 
    130                 135                 140                 


Pro Lys Ala Lys Met Val Leu Arg Ile Ser Thr Asp Asp Ser Leu Ala 
145                 150                 155                 160 


Arg Cys Arg Leu Ser Val Lys Phe Gly Ala Lys Val Glu Asp Cys Arg 
                165                 170                 175     


Phe Ile Leu Glu Gln Ala Lys Lys Leu Asn Ile Asp Val Thr Gly Val 
            180                 185                 190         


Ser Phe His Val Gly Ser Gly Ser Thr Asp Ala Ser Thr Phe Ala Gln 
        195                 200                 205             


Ala Ile Ser Asp Ser Arg Phe Val Phe Asp Met Gly Thr Glu Leu Gly 
    210                 215                 220                 


Phe Asn Met His Ile Leu Asp Ile Gly Gly Gly Phe Pro Gly Thr Arg 
225                 230                 235                 240 


Asp Ala Pro Leu Lys Phe Glu Glu Ile Ala Gly Val Ile Asn Asn Ala 
                245                 250                 255     


Leu Glu Lys His Phe Pro Pro Asp Leu Lys Leu Thr Ile Val Ala Glu 
            260                 265                 270         


Pro Gly Arg Tyr Tyr Val Ala Ser Ala Phe Thr Leu Ala Val Asn Val 
        275                 280                 285             


Ile Ala Lys Lys Val Thr Pro Gly Val Gln Thr Asp Val Gly Ala His 
    290                 295                 300                 


Ala Glu Ser Asn Ala Gln Ser Phe Met Tyr Tyr Val Asn Asp Gly Val 
305                 310                 315                 320 


Tyr Gly Ser Phe Asn Cys Ile Leu Tyr Asp His Ala Val Val Arg Pro 
                325                 330                 335     


Leu Pro Gln Arg Glu Pro Ile Pro Asn Glu Lys Leu Tyr Pro Ser Ser 
            340                 345                 350         


Val Trp Gly Pro Thr Cys Asp Gly Leu Asp Gln Ile Val Glu Arg Tyr 
        355                 360                 365             


Tyr Leu Pro Glu Met Gln Val Gly Glu Trp Leu Leu Phe Glu Asp Met 
    370                 375                 380                 


Gly Ala Tyr Thr Val Val Gly Thr Ser Ser Phe Asn Gly Phe Gln Ser 
385                 390                 395                 400 


Pro Thr Ile Tyr Tyr Val Val Ser Gly Leu Pro Asp His Val Val Arg 
                405                 410                 415     


Glu Leu Lys Ser Gln Lys Ser 
            420             


<210>  12
<211>  637
<212>  PRT
<213>  Xanthomonas campestris

<400>  12

Met Ile Ala Ser Ser Pro Ile Asp Ala Ala Ala Leu Arg Ala Ser Val 
1               5                   10                  15      


Ala Ala Ala Leu Asp Pro Ser Thr Ala Val Ala Thr Leu Ala Arg Phe 
            20                  25                  30          


Asp Thr His Ala Pro Arg Leu Leu Asp Ala Leu Ser Thr Leu Tyr Gly 
        35                  40                  45              


Asp His Ala Asp Tyr Val Thr Trp Leu Pro Gln Trp Leu Ser Ala Leu 
    50                  55                  60                  


Gly Val Val Ala Gln Ala Arg Pro Ala Ala Leu Arg His Leu Asp Asp 
65                  70                  75                  80  


Ser Arg Ala Pro Gly Trp Phe Gly Gln Gln Asp Met Leu Gly Tyr Ser 
                85                  90                  95      


Ala Tyr Val Asp Arg Phe Ala Gly Thr Leu Arg Gly Val Ala Glu Arg 
            100                 105                 110         


Val Pro Tyr Leu Gln Glu Leu Gly Val Arg Tyr Leu His Leu Leu Pro 
        115                 120                 125             


Phe Leu Arg Ala Arg Ala Gly Asp Asn Asp Gly Gly Phe Ala Val Ser 
    130                 135                 140                 


Asp Tyr Gly Gln Val Glu Pro Ala Leu Gly Ser Asn Asp Asp Leu Val 
145                 150                 155                 160 


Ala Leu Thr Ala Arg Leu Arg Ala Ala Asn Ile Ser Leu Cys Ala Asp 
                165                 170                 175     


Phe Val Leu Asn His Thr Ala Asp Asp His Ala Trp Ala Gln Ala Ala 
            180                 185                 190         


Arg Ala Gly Asp Thr Arg Tyr Leu Asp Tyr Tyr His His Phe Ala Asp 
        195                 200                 205             


Arg Asn Ala Pro Asp Gln Tyr Asp Thr Thr Leu Val Gln Val Phe Pro 
    210                 215                 220                 


Gln Thr Ala Pro Gly Asn Phe Thr Trp Val Asp Glu Thr Arg Gln Trp 
225                 230                 235                 240 


Met Trp Thr Thr Phe Tyr Pro Tyr Gln Trp Asp Leu Asn Trp Ser Asn 
                245                 250                 255     


Pro Ala Val Phe Gly Glu Met Ala Leu Ala Met Leu Glu Leu Ala Asn 
            260                 265                 270         


Leu Gly Val Glu Ala Phe Arg Leu Asp Ser Thr Ala Tyr Leu Trp Lys 
        275                 280                 285             


Arg Pro Gly Thr Asn Cys Met Asn Gln Pro Glu Ala His Thr Ile Leu 
    290                 295                 300                 


Val Ala Leu Arg Ala Val Ala Asp Ile Val Ala Pro Ser Val Val Met 
305                 310                 315                 320 


Lys Ala Glu Ala Ile Val Pro Met Ala Glu Leu Pro Pro Tyr Phe Gly 
                325                 330                 335     


Ser Gly Val Gln Arg Gly His Glu Cys His Leu Ala Tyr His Ser Thr 
            340                 345                 350         


Leu Met Ala Ala Gly Trp Ser Ala Leu Ala Leu Gln Arg Gly Asp Ile 
        355                 360                 365             


Leu Gln Asp Val Ile Ala His Ser Pro Pro Leu Pro Pro Asn Cys Ala 
    370                 375                 380                 


Trp Leu Ser Tyr Val Arg Cys His Asp Asp Ile Gly Trp Asn Val Leu 
385                 390                 395                 400 


Gln His Glu Ala Ala Gly Thr Ala Ala Gln Pro Pro Phe Ser Leu Arg 
                405                 410                 415     


Glu Val Ala Gln Phe Tyr Ala Asn Ala Val Pro Gly Ser Tyr Ala Arg 
            420                 425                 430         


Gly Glu Ser Phe Gln Ser Ser Gly Asp Gly Val His Gly Thr Asn Gly 
        435                 440                 445             


Met Ser Ala Ala Leu Val Gly Val Gln Ala Ala His Glu His Ala Asp 
    450                 455                 460                 


Ala Ala Ala Ala Ala Arg Ala Val Asp Arg Leu Val Leu Leu Tyr Ala 
465                 470                 475                 480 


Val Ser Leu Ala Met Pro Gly Val Pro Leu Ile Tyr Met Gly Asp Glu 
                485                 490                 495     


Leu Ala Leu Pro Asn Asp Thr Ala Tyr Leu Asp Asp Ala Gln Arg Arg 
            500                 505                 510         


His Glu Gly Arg Trp Leu His Arg Pro Ala Met Ala Trp Glu Leu Ala 
        515                 520                 525             


Ala Gln Arg His Asp Ala Ser Thr Leu Ala Gly Thr Val Tyr Thr Arg 
    530                 535                 540                 


Leu Arg Ala Leu Ile Arg Leu Arg Ala Gly Leu Pro Ala Leu Ala Ala 
545                 550                 555                 560 


Thr Gln Ser Leu Gly Ser Val Ala Leu Gly Asp Ala Arg Leu Phe Ala 
                565                 570                 575     


Leu Thr Arg Gly Asp Ser Phe Leu Ala Val His Asn Phe Ser Asp Val 
            580                 585                 590         


Pro Leu Pro Val Asp Leu Thr Gln Thr Gly His Ala Leu Trp Ala Val 
        595                 600                 605             


Leu Asp Thr Asp Gly Thr Gly Asp Ala Pro Glu Pro His Thr Glu Leu 
    610                 615                 620                 


Leu Leu Pro Ala Tyr Gly Val Arg Trp Leu Gln Arg Arg 
625                 630                 635         


<210>  13
<211>  644
<212>  PRT
<213>  Xanthomonas campestris

<400>  13

Met Ser Thr Cys Pro Ile Asp Pro Pro Ala Leu Arg Ala Ala Phe Ala 
1               5                   10                  15      


Gly Pro Leu Asp Pro Gln His Ala Glu Val Leu Leu Ser Arg Tyr Asp 
            20                  25                  30          


Gln His Ala Ser Arg Leu Leu Asp Ala Leu His Ala Leu Tyr Gly Gln 
        35                  40                  45              


Arg Ala Asp Tyr Ala Ser Trp Leu Ala Gln Trp Leu Gly Glu Val Gly 
    50                  55                  60                  


Asp Ile Ala Arg Gln Arg Pro Gln Ala Leu Gln Thr Leu Asp Ser Thr 
65                  70                  75                  80  


Arg His Ala Gly Trp Phe Gly Gln Pro His Met Leu Gly Tyr Ser Ala 
                85                  90                  95      


Tyr Ala Asp Arg Phe Ala Gly Thr Leu Gln Gly Val Ala Glu Arg Val 
            100                 105                 110         


Pro Tyr Leu Gln Glu Leu Gly Val Arg Tyr Leu His Leu Leu Pro Phe 
        115                 120                 125             


Leu Arg Ala Arg Ala Gly Asp Asn Asp Gly Gly Phe Ala Val Ser Asp 
    130                 135                 140                 


Tyr Gly Gln Val Glu Pro Ser Leu Gly Ser Asn Asp Asp Leu Val Ala 
145                 150                 155                 160 


Leu Thr Ser Arg Leu Arg Glu Ala Gly Ile Ser Leu Cys Ala Asp Phe 
                165                 170                 175     


Val Leu Asn His Thr Ala Asp Asp His Ala Trp Ala Gln Ala Ala Arg 
            180                 185                 190         


Ala Gly Asp Ala Arg Tyr Leu Asp Tyr Tyr His His Phe Ala Asp Arg 
        195                 200                 205             


Thr Val Pro Asp Arg Tyr Glu Ala Thr Leu Gly Gln Val Phe Pro His 
    210                 215                 220                 


Thr Ala Pro Gly Asn Phe Thr Trp Val Asp Asp Thr Ala Gln Trp Met 
225                 230                 235                 240 


Trp Thr Thr Phe Tyr Pro Tyr Gln Trp Asp Leu Asn Trp Ser Asn Pro 
                245                 250                 255     


Ala Val Phe Gly Asp Met Ala Leu Ala Met Leu Arg Leu Ala Asn Leu 
            260                 265                 270         


Gly Val Glu Ala Phe Arg Leu Asp Ser Thr Ala Tyr Leu Trp Lys Arg 
        275                 280                 285             


Ile Gly Thr Asp Cys Met Asn Gln Ser Glu Ala His Thr Leu Leu Val 
    290                 295                 300                 


Ala Leu Arg Ala Val Thr Asp Ile Val Ala Pro Ala Val Val Met Lys 
305                 310                 315                 320 


Ala Glu Ala Ile Val Pro Met Thr Gln Leu Pro Pro Tyr Phe Gly Ser 
                325                 330                 335     


Gly Val Asp Glu Gly His Glu Cys His Leu Ala Tyr His Ser Thr Leu 
            340                 345                 350         


Met Ala Ala Gly Trp Ser Ala Leu Ala Leu Gln Arg Gly Asp Ile Leu 
        355                 360                 365             


His Asn Val Ile Ala His Ser Pro Pro Leu Pro Arg His Cys Ala Trp 
    370                 375                 380                 


Leu Ser Tyr Val Arg Cys His Asp Asp Ile Gly Trp Asn Val Leu Gln 
385                 390                 395                 400 


His Glu Ala Cys Gly Asn Ala Ala Gln Pro Pro Phe Ser Leu Arg Asp 
                405                 410                 415     


Val Ala Arg Phe Tyr Ala Asn Ala Val Pro Gly Ser Tyr Ala Arg Gly 
            420                 425                 430         


Glu Ser Phe Gln Ser Ser Gly Asp Gly Val His Gly Thr Asn Gly Met 
        435                 440                 445             


Ala Ala Ala Leu Ala Gly Ile Gln Ala Ala Gln Glu Ala Gly Asp Ala 
    450                 455                 460                 


Ala Ala Leu Ala Val Ala Val Asp Arg Leu Val Leu Leu Tyr Ala Ile 
465                 470                 475                 480 


Ala Leu Ala Met Pro Gly Val Pro Leu Ile Tyr Met Gly Asp Glu Leu 
                485                 490                 495     


Ala Met Val Asn Asp Pro Gly Tyr Arg Asp Asp Pro His Arg Gln His 
            500                 505                 510         


Glu Gly Arg Trp Leu His Arg Pro Ala Met Asp Trp Gln Leu Ala Ala 
        515                 520                 525             


Gln Arg His Asp Ala Lys Ser Leu Ser Gly Thr Val Tyr Arg Arg Leu 
    530                 535                 540                 


Arg Gly Leu Ile Arg Gln Arg Ala Ala Leu Gly Ala Leu Ala Ala Asp 
545                 550                 555                 560 


Gln Ala Leu Ala Ser Ile Ala Leu Asn Asp Pro Arg Val Phe Ala Leu 
                565                 570                 575     


Thr Arg Gly Asp Ser Phe Ile Ala Leu His Asn Phe Ser Asp Gln Leu 
            580                 585                 590         


Leu Asp Val Glu Leu Ala Ala Ile Gly Val Asp Gly Trp Thr Leu Leu 
        595                 600                 605             


Ala Ile Asp Asp Ala Ile Gly Gly Ala Ala Ala Arg Gly Asp Gly Ser 
    610                 615                 620                 


Ile Val Leu Pro Pro Tyr Gly Val Arg Trp Leu Gln Arg Gly Thr Glu 
625                 630                 635                 640 


His Ala Pro Glu 
                


<210>  14
<211>  193
<212>  PRT
<213>  Salmonella typhimurium

<400>  14

Met Ala Arg Pro Lys Ser Glu Asp Lys Lys Gln Ala Leu Leu Glu Ala 
1               5                   10                  15      


Ala Thr Gln Ala Ile Ala Gln Ser Gly Ile Ala Ala Ser Thr Ala Val 
            20                  25                  30          


Ile Ala Arg Asn Ala Gly Val Ala Glu Gly Thr Leu Phe Arg Tyr Phe 
        35                  40                  45              


Ala Thr Lys Asp Glu Leu Ile Asn Thr Leu Tyr Leu His Leu Lys Gln 
    50                  55                  60                  


Asp Leu Cys Gln Ser Met Ile Met Glu Leu Asp Arg Ser Ile Thr Asp 
65                  70                  75                  80  


Ala Lys Met Met Thr Arg Phe Ile Trp Asn Ser Tyr Ile Ser Trp Gly 
                85                  90                  95      


Leu Asn His Pro Ala Arg His Arg Ala Ile Arg Gln Leu Ala Val Ser 
            100                 105                 110         


Glu Lys Leu Thr Lys Glu Thr Glu Gln Arg Ala Asp Asp Met Phe Pro 
        115                 120                 125             


Glu Leu Arg Asp Leu Cys His Arg Ser Val Leu Met Val Phe Met Ser 
    130                 135                 140                 


Asp Glu Tyr Arg Ala Phe Gly Asp Gly Leu Phe Leu Ala Leu Ala Glu 
145                 150                 155                 160 


Thr Thr Met Asp Phe Ala Ala Arg Asp Pro Ala Arg Ala Gly Glu Tyr 
                165                 170                 175     


Ile Ala Leu Gly Phe Glu Ala Met Trp Arg Ala Leu Thr Arg Glu Glu 
            180                 185                 190         


Gln 
    


<210>  15
<211>  397
<212>  PRT
<213>  Human cytomegalovirus

<400>  15

Met Glu Met Asn Lys Val Leu His Gln Asp Leu Val Gln Ala Thr Arg 
1               5                   10                  15      


Arg Ile Leu Lys Leu Gly Pro Ser Glu Leu Arg Val Thr Asp Ala Gly 
            20                  25                  30          


Leu Ile Cys Lys Asn Pro Asn Tyr Ser Val Cys Asp Ala Met Leu Lys 
        35                  40                  45              


Thr Asp Thr Val Tyr Cys Val Glu Tyr Leu Leu Ser Tyr Trp Glu Ser 
    50                  55                  60                  


Arg Thr Asp His Val Pro Cys Phe Ile Phe Lys Asn Thr Gly Cys Ala 
65                  70                  75                  80  


Val Ser Leu Cys Cys Phe Val Arg Ala Pro Val Lys Leu Val Ser Pro 
                85                  90                  95      


Ala Arg His Val Gly Glu Phe Asn Val Leu Lys Val Asn Glu Ser Leu 
            100                 105                 110         


Ile Val Thr Leu Lys Asp Ile Glu Glu Ile Lys Pro Ser Ala Tyr Gly 
        115                 120                 125             


Val Leu Thr Lys Cys Val Val Arg Lys Ser Asn Ser Ala Ser Val Phe 
    130                 135                 140                 


Asn Ile Glu Leu Ile Ala Phe Gly Pro Glu Asn Glu Gly Glu Tyr Glu 
145                 150                 155                 160 


Asn Leu Leu Arg Glu Leu Tyr Ala Lys Lys Ala Ala Ser Thr Ser Leu 
                165                 170                 175     


Ala Val Arg Asn His Val Thr Val Ser Ser His Ser Gly Ser Gly Pro 
            180                 185                 190         


Ser Leu Trp Arg Ala Arg Met Ser Ala Ala Leu Thr Arg Thr Ala Gly 
        195                 200                 205             


Lys Arg Ser Ser Arg Thr Ala Ser Pro Pro Pro Pro Pro Arg His Pro 
    210                 215                 220                 


Ser Cys Ser Pro Thr Met Val Ala Ala Gly Gly Ala Ala Ala Gly Pro 
225                 230                 235                 240 


Arg Pro Pro Pro Pro Pro Met Ala Ala Gly Ser Trp Arg Leu Cys Arg 
                245                 250                 255     


Cys Glu Ala Cys Met Gly Arg Cys Gly Cys Ala Ser Glu Gly Asp Ala 
            260                 265                 270         


Asp Glu Glu Glu Glu Glu Leu Leu Ala Leu Ala Gly Glu Gly Lys Ala 
        275                 280                 285             


Ala Ala Ala Ala Ala Gly Gln Asp Val Gly Gly Ser Ala Arg Arg Pro 
    290                 295                 300                 


Leu Glu Glu His Val Ser Arg Arg Arg Gly Val Ser Thr His His Arg 
305                 310                 315                 320 


His Pro Pro Ser Pro Pro Cys Ala Pro Ser Leu Glu Arg Thr Gly Tyr 
                325                 330                 335     


Arg Trp Ala Pro Ser Ser Trp Trp Arg Ala Arg Ser Gly Pro Ser Arg 
            340                 345                 350         


Pro Gln Ser Gly Pro Trp Leu Pro Ala Arg Phe Ala Thr Leu Gly Pro 
        355                 360                 365             


Leu Val Leu Ala Leu Leu Leu Val Leu Ala Leu Leu Trp Arg Gly His 
    370                 375                 380                 


Gly Gln Ser Ser Ser Pro Thr Arg Ser Ala His Arg Asp 
385                 390                 395         


<210>  16
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Pro Ala Arg Ala Leu Leu Pro Arg Arg Met Gly His Arg Thr Leu 
1               5                   10                  15      


Ala Ser Thr Pro Ala Leu Trp Ala Ser Ile Pro Cys Pro Arg Ser Glu 
            20                  25                  30          


Leu Arg Leu Asp Leu Val Leu Pro Ser Gly Gln Ser Phe Arg Trp Arg 
        35                  40                  45              


Glu Gln Ser Pro Ala His Trp Ser Gly Val Leu Ala Asp Gln Val Trp 
    50                  55                  60                  


Thr Leu Thr Gln Thr Glu Glu Gln Leu His Cys Thr Val Tyr Arg Gly 
65                  70                  75                  80  


Asp Lys Ser Gln Ala Ser Arg Pro Thr Pro Asp Glu Leu Glu Ala Val 
                85                  90                  95      


Arg Lys Tyr Phe Gln Leu Asp Val Thr Leu Ala Gln Leu Tyr His His 
            100                 105                 110         


Trp Gly Ser Val Asp Ser His Phe Gln Glu Val Ala Gln Lys Phe Gln 
        115                 120                 125             


Gly Val Arg Leu Leu Arg Gln Asp Pro Ile Glu Cys Leu Phe Ser Phe 
    130                 135                 140                 


Ile Cys Ser Ser Asn Asn Asn Ile Ala Arg Ile Thr Gly Met Val Glu 
145                 150                 155                 160 


Arg Leu Cys Gln Ala Phe Gly Pro Arg Leu Ile Gln Leu Asp Asp Val 
                165                 170                 175     


Thr Tyr His Gly Phe Pro Ser Leu Gln Ala Leu Ala Gly Pro Glu Val 
            180                 185                 190         


Glu Ala His Leu Arg Lys Leu Gly Leu Gly Tyr Arg Ala Arg Tyr Val 
        195                 200                 205             


Ser Ala Ser Ala Arg Ala Ile Leu Glu Glu Gln Gly Gly Leu Ala Trp 
    210                 215                 220                 


Leu Gln Gln Leu Arg Glu Ser Ser Tyr Glu Glu Ala His Lys Ala Leu 
225                 230                 235                 240 


Cys Ile Leu Pro Gly Val Gly Thr Lys Val Ala Asp Cys Ile Cys Leu 
                245                 250                 255     


Met Ala Leu Asp Lys Pro Gln Ala Val Pro Val Asp Val His Met Trp 
            260                 265                 270         


His Ile Ala Gln Arg Asp Tyr Ser Trp His Pro Thr Thr Ser Gln Ala 
        275                 280                 285             


Lys Gly Pro Ser Pro Gln Thr Asn Lys Glu Leu Gly Asn Phe Phe Arg 
    290                 295                 300                 


Ser Leu Trp Gly Pro Tyr Ala Gly Trp Ala Gln Ala Val Leu Phe Ser 
305                 310                 315                 320 


Ala Asp Leu Arg Gln Ser Arg His Ala Gln Glu Pro Pro Ala Lys Arg 
                325                 330                 335     


Arg Lys Gly Ser Lys Gly Pro Glu Gly 
            340                 345 


<210>  17
<211>  365
<212>  PRT
<213>  Human adenovirus type 19

<400>  17

Met Ser Lys Arg Leu Arg Val Glu Asp Asp Phe Asn Pro Val Tyr Pro 
1               5                   10                  15      


Tyr Gly Tyr Ala Arg Asn Gln Asn Ile Pro Phe Leu Thr Pro Pro Phe 
            20                  25                  30          


Val Ser Ser Asp Gly Phe Lys Asn Phe Pro Pro Gly Val Leu Ser Leu 
        35                  40                  45              


Lys Leu Ala Asp Pro Ile Thr Ile Thr Asn Gly Asp Val Ser Leu Lys 
    50                  55                  60                  


Val Gly Gly Gly Leu Thr Leu Gln Asp Gly Ser Leu Thr Val Asn Pro 
65                  70                  75                  80  


Lys Ala Pro Leu Gln Val Thr Thr Asp Lys Lys Leu Glu Leu Ala Tyr 
                85                  90                  95      


Asp Asn Pro Phe Glu Cys Ser Ala Asn Lys Phe Ser Leu Lys Val Gly 
            100                 105                 110         


His Gly Leu Lys Val Leu Asp Glu Lys Ser Ala Ala Gly Leu Lys Asp 
        115                 120                 125             


Leu Ile Gly Lys Leu Val Val Leu Thr Gly Lys Gly Ile Gly Thr Glu 
    130                 135                 140                 


Asn Leu Glu Asn Thr Asp Gly Ser Ser Arg Gly Ile Gly Ile Asn Val 
145                 150                 155                 160 


Arg Ala Arg Glu Gly Leu Thr Phe Asp Asn Asp Gly Tyr Leu Val Ala 
                165                 170                 175     


Trp Asn Pro Lys Tyr Asp Thr Arg Thr Leu Trp Thr Thr Pro Asp Thr 
            180                 185                 190         


Ser Pro Asn Cys Thr Ile Ala Gln Asp Lys Asp Ser Lys Leu Thr Leu 
        195                 200                 205             


Val Leu Thr Lys Cys Gly Ser Gln Ile Leu Ala Asn Val Ser Leu Ile 
    210                 215                 220                 


Val Val Ala Gly Lys Tyr His Ile Ile Asn Asn Lys Thr Asn Pro Glu 
225                 230                 235                 240 


Ile Lys Ser Phe Thr Ile Lys Leu Leu Phe Asn Lys Asn Gly Val Leu 
                245                 250                 255     


Leu Asp Asn Ser Asn Leu Gly Lys Ala Tyr Trp Asn Phe Arg Ser Gly 
            260                 265                 270         


Asn Ser Asn Val Ser Thr Ala Tyr Glu Lys Ala Ile Gly Phe Met Pro 
        275                 280                 285             


Asn Leu Val Ala Tyr Pro Lys Pro Ser Asn Ser Lys Lys Tyr Ala Arg 
    290                 295                 300                 


Asp Ile Val Tyr Gly Thr Ile Tyr Leu Gly Gly Lys Pro Asp Gln Pro 
305                 310                 315                 320 


Ala Val Ile Lys Thr Thr Phe Asn Gln Glu Thr Gly Cys Glu Tyr Ser 
                325                 330                 335     


Ile Thr Phe Asp Phe Ser Trp Ser Lys Thr Tyr Glu Asn Val Glu Phe 
            340                 345                 350         


Glu Thr Thr Ser Phe Thr Phe Ser Tyr Ile Ala Gln Glu 
        355                 360                 365 


<210>  18
<211>  1052
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Ala Ala Tyr Leu Asp Pro Asn Leu Asn His Thr Pro Asn Ser 
1               5                   10                  15      


Ser Thr Lys Thr His Leu Gly Thr Gly Met Glu Arg Ser Pro Gly Ala 
            20                  25                  30          


Met Glu Arg Val Leu Lys Val Phe His Tyr Phe Glu Ser Asn Ser Glu 
        35                  40                  45              


Pro Thr Thr Trp Ala Ser Ile Ile Arg His Gly Asp Ala Thr Asp Val 
    50                  55                  60                  


Arg Gly Ile Ile Gln Lys Ile Val Asp Ser His Lys Val Lys His Val 
65                  70                  75                  80  


Ala Cys Tyr Gly Phe Arg Leu Ser His Leu Arg Ser Glu Glu Val His 
                85                  90                  95      


Trp Leu His Val Asp Met Gly Val Ser Ser Val Arg Glu Lys Tyr Glu 
            100                 105                 110         


Leu Ala His Pro Pro Glu Glu Trp Lys Tyr Glu Leu Arg Ile Arg Tyr 
        115                 120                 125             


Leu Pro Lys Gly Phe Leu Asn Gln Phe Thr Glu Asp Lys Pro Thr Leu 
    130                 135                 140                 


Asn Phe Phe Tyr Gln Gln Val Lys Ser Asp Tyr Met Leu Glu Ile Ala 
145                 150                 155                 160 


Asp Gln Val Asp Gln Glu Ile Ala Leu Lys Leu Gly Cys Leu Glu Ile 
                165                 170                 175     


Arg Arg Ser Tyr Trp Glu Met Arg Gly Asn Ala Leu Glu Lys Lys Ser 
            180                 185                 190         


Asn Tyr Glu Val Leu Glu Lys Asp Val Gly Leu Lys Arg Phe Phe Pro 
        195                 200                 205             


Lys Ser Leu Leu Asp Ser Val Lys Ala Lys Thr Leu Arg Lys Leu Ile 
    210                 215                 220                 


Gln Gln Thr Phe Arg Gln Phe Ala Asn Leu Asn Arg Glu Glu Ser Ile 
225                 230                 235                 240 


Leu Lys Phe Phe Glu Ile Leu Ser Pro Val Tyr Arg Phe Asp Lys Glu 
                245                 250                 255     


Cys Phe Lys Cys Ala Leu Gly Ser Ser Trp Ile Ile Ser Val Glu Leu 
            260                 265                 270         


Ala Ile Gly Pro Glu Glu Gly Ile Ser Tyr Leu Thr Asp Lys Gly Cys 
        275                 280                 285             


Asn Pro Thr His Leu Ala Asp Phe Thr Gln Val Gln Thr Ile Gln Tyr 
    290                 295                 300                 


Ser Asn Ser Glu Asp Lys Asp Arg Lys Gly Met Leu Gln Leu Lys Ile 
305                 310                 315                 320 


Ala Gly Ala Pro Glu Pro Leu Thr Val Thr Ala Pro Ser Leu Thr Ile 
                325                 330                 335     


Ala Glu Asn Met Ala Asp Leu Ile Asp Gly Tyr Cys Arg Leu Val Asn 
            340                 345                 350         


Gly Thr Ser Gln Ser Phe Ile Ile Arg Pro Gln Lys Glu Gly Glu Arg 
        355                 360                 365             


Ala Leu Pro Ser Ile Pro Lys Leu Ala Asn Ser Glu Lys Gln Gly Met 
    370                 375                 380                 


Arg Thr His Ala Val Ser Val Ser Glu Thr Asp Asp Tyr Ala Glu Ile 
385                 390                 395                 400 


Ile Asp Glu Glu Asp Thr Tyr Thr Met Pro Ser Thr Arg Asp Tyr Glu 
                405                 410                 415     


Ile Gln Arg Glu Arg Ile Glu Leu Gly Arg Cys Ile Gly Glu Gly Gln 
            420                 425                 430         


Phe Gly Asp Val His Gln Gly Ile Tyr Met Ser Pro Glu Asn Pro Ala 
        435                 440                 445             


Leu Ala Val Ala Ile Lys Thr Cys Lys Asn Cys Thr Ser Asp Ser Val 
    450                 455                 460                 


Arg Glu Lys Phe Leu Gln Glu Ala Leu Thr Met Arg Gln Phe Asp His 
465                 470                 475                 480 


Pro His Ile Val Lys Leu Ile Gly Val Ile Thr Glu Asn Pro Val Trp 
                485                 490                 495     


Ile Ile Met Glu Leu Cys Thr Leu Gly Glu Leu Arg Ser Phe Leu Gln 
            500                 505                 510         


Val Arg Lys Tyr Ser Leu Asp Leu Ala Ser Leu Ile Leu Tyr Ala Tyr 
        515                 520                 525             


Gln Leu Ser Thr Ala Leu Ala Tyr Leu Glu Ser Lys Arg Phe Val His 
    530                 535                 540                 


Arg Asp Ile Ala Ala Arg Asn Val Leu Val Ser Ser Asn Asp Cys Val 
545                 550                 555                 560 


Lys Leu Gly Asp Phe Gly Leu Ser Arg Tyr Met Glu Asp Ser Thr Tyr 
                565                 570                 575     


Tyr Lys Ala Ser Lys Gly Lys Leu Pro Ile Lys Trp Met Ala Pro Glu 
            580                 585                 590         


Ser Ile Asn Phe Arg Arg Phe Thr Ser Ala Ser Asp Val Trp Met Phe 
        595                 600                 605             


Gly Val Cys Met Trp Glu Ile Leu Met His Gly Val Lys Pro Phe Gln 
    610                 615                 620                 


Gly Val Lys Asn Asn Asp Val Ile Gly Arg Ile Glu Asn Gly Glu Arg 
625                 630                 635                 640 


Leu Pro Met Pro Pro Asn Cys Pro Pro Thr Leu Tyr Ser Leu Met Thr 
                645                 650                 655     


Lys Cys Trp Ala Tyr Asp Pro Ser Arg Arg Pro Arg Phe Thr Glu Leu 
            660                 665                 670         


Lys Ala Gln Leu Ser Thr Ile Leu Glu Glu Glu Lys Ala Gln Gln Glu 
        675                 680                 685             


Glu Arg Met Arg Met Glu Ser Arg Arg Gln Ala Thr Val Ser Trp Asp 
    690                 695                 700                 


Ser Gly Gly Ser Asp Glu Ala Pro Pro Lys Pro Ser Arg Pro Gly Tyr 
705                 710                 715                 720 


Pro Ser Pro Arg Ser Ser Glu Gly Phe Tyr Pro Ser Pro Gln His Met 
                725                 730                 735     


Val Gln Thr Asn His Tyr Gln Val Ser Gly Tyr Pro Gly Ser His Gly 
            740                 745                 750         


Ile Thr Ala Met Ala Gly Ser Ile Tyr Pro Gly Gln Ala Ser Leu Leu 
        755                 760                 765             


Asp Gln Thr Asp Ser Trp Asn His Arg Pro Gln Glu Ile Ala Met Trp 
    770                 775                 780                 


Gln Pro Asn Val Glu Asp Ser Thr Val Leu Asp Leu Arg Gly Ile Gly 
785                 790                 795                 800 


Gln Val Leu Pro Thr His Leu Met Glu Glu Arg Leu Ile Arg Gln Gln 
                805                 810                 815     


Gln Glu Met Glu Glu Asp Gln Arg Trp Leu Glu Lys Glu Glu Arg Phe 
            820                 825                 830         


Leu Lys Pro Asp Val Arg Leu Ser Arg Gly Ser Ile Asp Arg Glu Asp 
        835                 840                 845             


Gly Ser Leu Gln Gly Pro Ile Gly Asn Gln His Ile Tyr Gln Pro Val 
    850                 855                 860                 


Gly Lys Pro Asp Pro Ala Ala Pro Pro Lys Lys Pro Pro Arg Pro Gly 
865                 870                 875                 880 


Ala Pro Gly His Leu Gly Ser Leu Ala Ser Leu Ser Ser Pro Ala Asp 
                885                 890                 895     


Ser Tyr Asn Glu Gly Val Lys Leu Gln Pro Gln Glu Ile Ser Pro Pro 
            900                 905                 910         


Pro Thr Ala Asn Leu Asp Arg Ser Asn Asp Lys Val Tyr Glu Asn Val 
        915                 920                 925             


Thr Gly Leu Val Lys Ala Val Ile Glu Met Ser Ser Lys Ile Gln Pro 
    930                 935                 940                 


Ala Pro Pro Glu Glu Tyr Val Pro Met Val Lys Glu Val Gly Leu Ala 
945                 950                 955                 960 


Leu Arg Thr Leu Leu Ala Thr Val Asp Glu Thr Ile Pro Leu Leu Pro 
                965                 970                 975     


Ala Ser Thr His Arg Glu Ile Glu Met Ala Gln Lys Leu Leu Asn Ser 
            980                 985                 990         


Asp Leu Gly Glu Leu Ile Asn Lys  Met Lys Leu Ala Gln  Gln Tyr Val 
        995                 1000                 1005             


Met Thr  Ser Leu Gln Gln Glu  Tyr Lys Lys Gln Met  Leu Thr Ala 
    1010                 1015                 1020             


Ala His  Ala Leu Ala Val Asp  Ala Lys Asn Leu Leu  Asp Val Ile 
    1025                 1030                 1035             


Asp Gln  Ala Arg Leu Lys Met  Leu Gly Gln Thr Arg  Pro His 
    1040                 1045                 1050         


<210>  19
<211>  484
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Arg His Ser Lys Arg Thr Tyr Cys Pro Asp Trp Asp Asp Lys Asp 
1               5                   10                  15      


Trp Asp Tyr Gly Lys Trp Arg Ser Ser Ser Ser His Lys Arg Arg Lys 
            20                  25                  30          


Arg Ser His Ser Ser Ala Gln Glu Asn Lys Arg Cys Lys Tyr Asn His 
        35                  40                  45              


Ser Lys Met Cys Asp Ser His Tyr Leu Glu Ser Arg Ser Ile Asn Glu 
    50                  55                  60                  


Lys Asp Tyr His Ser Arg Arg Tyr Ile Asp Glu Tyr Arg Asn Asp Tyr 
65                  70                  75                  80  


Thr Gln Gly Cys Glu Pro Gly His Arg Gln Arg Asp His Glu Ser Arg 
                85                  90                  95      


Tyr Gln Asn His Ser Ser Lys Ser Ser Gly Arg Ser Gly Arg Ser Ser 
            100                 105                 110         


Tyr Lys Ser Lys His Arg Ile His His Ser Thr Ser His Arg Arg Ser 
        115                 120                 125             


His Gly Lys Ser His Arg Arg Lys Arg Thr Arg Ser Val Glu Asp Asp 
    130                 135                 140                 


Glu Glu Gly His Leu Ile Cys Gln Ser Gly Asp Val Leu Ser Ala Arg 
145                 150                 155                 160 


Tyr Glu Ile Val Asp Thr Leu Gly Glu Gly Ala Phe Gly Lys Val Val 
                165                 170                 175     


Glu Cys Ile Asp His Lys Ala Gly Gly Arg His Val Ala Val Lys Ile 
            180                 185                 190         


Val Lys Asn Val Asp Arg Tyr Cys Glu Ala Ala Arg Ser Glu Ile Gln 
        195                 200                 205             


Val Leu Glu His Leu Asn Thr Thr Asp Pro Asn Ser Thr Phe Arg Cys 
    210                 215                 220                 


Val Gln Met Leu Glu Trp Phe Glu His His Gly His Ile Cys Ile Val 
225                 230                 235                 240 


Phe Glu Leu Leu Gly Leu Ser Thr Tyr Asp Phe Ile Lys Glu Asn Gly 
                245                 250                 255     


Phe Leu Pro Phe Arg Leu Asp His Ile Arg Lys Met Ala Tyr Gln Ile 
            260                 265                 270         


Cys Lys Ser Val Asn Phe Leu His Ser Asn Lys Leu Thr His Thr Asp 
        275                 280                 285             


Leu Lys Pro Glu Asn Ile Leu Phe Val Gln Ser Asp Tyr Thr Glu Ala 
    290                 295                 300                 


Tyr Asn Pro Lys Ile Lys Arg Asp Glu Arg Thr Leu Ile Asn Pro Asp 
305                 310                 315                 320 


Ile Lys Val Val Asp Phe Gly Ser Ala Thr Tyr Asp Asp Glu His His 
                325                 330                 335     


Ser Thr Leu Val Ser Thr Arg His Tyr Arg Ala Pro Glu Val Ile Leu 
            340                 345                 350         


Ala Leu Gly Trp Ser Gln Pro Cys Asp Val Trp Ser Ile Gly Cys Ile 
        355                 360                 365             


Leu Ile Glu Tyr Tyr Leu Gly Phe Thr Val Phe Pro Thr His Asp Ser 
    370                 375                 380                 


Lys Glu His Leu Ala Met Met Glu Arg Ile Leu Gly Pro Leu Pro Lys 
385                 390                 395                 400 


His Met Ile Gln Lys Thr Arg Lys Arg Lys Tyr Phe His His Asp Arg 
                405                 410                 415     


Leu Asp Trp Asp Glu His Ser Ser Ala Gly Arg Tyr Val Ser Arg Arg 
            420                 425                 430         


Cys Lys Pro Leu Lys Glu Phe Met Leu Ser Gln Asp Val Glu His Glu 
        435                 440                 445             


Arg Leu Phe Asp Leu Ile Gln Lys Met Leu Glu Tyr Asp Pro Ala Lys 
    450                 455                 460                 


Arg Ile Thr Leu Arg Glu Ala Leu Lys His Pro Phe Phe Asp Leu Leu 
465                 470                 475                 480 


Lys Lys Ser Ile 
                


<210>  20
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Cys Gly Leu Val Ala Ser Asn Leu Asn Leu Lys Pro Gly Glu 
1               5                   10                  15      


Cys Leu Arg Val Arg Gly Glu Val Ala Pro Asp Ala Lys Ser Phe Val 
            20                  25                  30          


Leu Asn Leu Gly Lys Asp Ser Asn Asn Leu Cys Leu His Phe Asn Pro 
        35                  40                  45              


Arg Phe Asn Ala His Gly Asp Ala Asn Thr Ile Val Cys Asn Ser Lys 
    50                  55                  60                  


Asp Gly Gly Ala Trp Gly Thr Glu Gln Arg Glu Ala Val Phe Pro Phe 
65                  70                  75                  80  


Gln Pro Gly Ser Val Ala Glu Val Cys Ile Thr Phe Asp Gln Ala Asn 
                85                  90                  95      


Leu Thr Val Lys Leu Pro Asp Gly Tyr Glu Phe Lys Phe Pro Asn Arg 
            100                 105                 110         


Leu Asn Leu Glu Ala Ile Asn Tyr Met Ala Ala Asp Gly Asp Phe Lys 
        115                 120                 125             


Ile Lys Cys Val Ala Phe Asp 
    130                 135 


<210>  21
<211>  1132
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Gly Met Ala Cys Leu Thr Met Thr Glu Met Glu Gly Thr Ser Thr 
1               5                   10                  15      


Ser Ser Ile Tyr Gln Asn Gly Asp Ile Ser Gly Asn Ala Asn Ser Met 
            20                  25                  30          


Lys Gln Ile Asp Pro Val Leu Gln Val Tyr Leu Tyr His Ser Leu Gly 
        35                  40                  45              


Lys Ser Glu Ala Asp Tyr Leu Thr Phe Pro Ser Gly Glu Tyr Val Ala 
    50                  55                  60                  


Glu Glu Ile Cys Ile Ala Ala Ser Lys Ala Cys Gly Ile Thr Pro Val 
65                  70                  75                  80  


Tyr His Asn Met Phe Ala Leu Met Ser Glu Thr Glu Arg Ile Trp Tyr 
                85                  90                  95      


Pro Pro Asn His Val Phe His Ile Asp Glu Ser Thr Arg His Asn Val 
            100                 105                 110         


Leu Tyr Arg Ile Arg Phe Tyr Phe Pro Arg Trp Tyr Cys Ser Gly Ser 
        115                 120                 125             


Asn Arg Ala Tyr Arg His Gly Ile Ser Arg Gly Ala Glu Ala Pro Leu 
    130                 135                 140                 


Leu Asp Asp Phe Val Met Ser Tyr Leu Phe Ala Gln Trp Arg His Asp 
145                 150                 155                 160 


Phe Val His Gly Trp Ile Lys Val Pro Val Thr His Glu Thr Gln Glu 
                165                 170                 175     


Glu Cys Leu Gly Met Ala Val Leu Asp Met Met Arg Ile Ala Lys Glu 
            180                 185                 190         


Asn Asp Gln Thr Pro Leu Ala Ile Tyr Asn Ser Ile Ser Tyr Lys Thr 
        195                 200                 205             


Phe Leu Pro Lys Cys Ile Arg Ala Lys Ile Gln Asp Tyr His Ile Leu 
    210                 215                 220                 


Thr Arg Lys Arg Ile Arg Tyr Arg Phe Arg Arg Phe Ile Gln Gln Phe 
225                 230                 235                 240 


Ser Gln Cys Lys Ala Thr Ala Arg Asn Leu Lys Leu Lys Tyr Leu Ile 
                245                 250                 255     


Asn Leu Glu Thr Leu Gln Ser Ala Phe Tyr Thr Glu Lys Phe Glu Val 
            260                 265                 270         


Lys Glu Pro Gly Ser Gly Pro Ser Gly Glu Glu Ile Phe Ala Thr Ile 
        275                 280                 285             


Ile Ile Thr Gly Asn Gly Gly Ile Gln Trp Ser Arg Gly Lys His Lys 
    290                 295                 300                 


Glu Ser Glu Thr Leu Thr Glu Gln Asp Leu Gln Leu Tyr Cys Asp Phe 
305                 310                 315                 320 


Pro Asn Ile Ile Asp Val Ser Ile Lys Gln Ala Asn Gln Glu Gly Ser 
                325                 330                 335     


Asn Glu Ser Arg Val Val Thr Ile His Lys Gln Asp Gly Lys Asn Leu 
            340                 345                 350         


Glu Ile Glu Leu Ser Ser Leu Arg Glu Ala Leu Ser Phe Val Ser Leu 
        355                 360                 365             


Ile Asp Gly Tyr Tyr Arg Leu Thr Ala Asp Ala His His Tyr Leu Cys 
    370                 375                 380                 


Lys Glu Val Ala Pro Pro Ala Val Leu Glu Asn Ile Gln Ser Asn Cys 
385                 390                 395                 400 


His Gly Pro Ile Ser Met Asp Phe Ala Ile Ser Lys Leu Lys Lys Ala 
                405                 410                 415     


Gly Asn Gln Thr Gly Leu Tyr Val Leu Arg Cys Ser Pro Lys Asp Phe 
            420                 425                 430         


Asn Lys Tyr Phe Leu Thr Phe Ala Val Glu Arg Glu Asn Val Ile Glu 
        435                 440                 445             


Tyr Lys His Cys Leu Ile Thr Lys Asn Glu Asn Glu Glu Tyr Asn Leu 
    450                 455                 460                 


Ser Gly Thr Lys Lys Asn Phe Ser Ser Leu Lys Asp Leu Leu Asn Cys 
465                 470                 475                 480 


Tyr Gln Met Glu Thr Val Arg Ser Asp Asn Ile Ile Phe Gln Phe Thr 
                485                 490                 495     


Lys Cys Cys Pro Pro Lys Pro Lys Asp Lys Ser Asn Leu Leu Val Phe 
            500                 505                 510         


Arg Thr Asn Gly Val Ser Asp Val Pro Thr Ser Pro Thr Leu Gln Arg 
        515                 520                 525             


Pro Thr His Met Asn Gln Met Val Phe His Lys Ile Arg Asn Glu Asp 
    530                 535                 540                 


Leu Ile Phe Asn Glu Ser Leu Gly Gln Gly Thr Phe Thr Lys Ile Phe 
545                 550                 555                 560 


Lys Gly Val Arg Arg Glu Val Gly Asp Tyr Gly Gln Leu His Glu Thr 
                565                 570                 575     


Glu Val Leu Leu Lys Val Leu Asp Lys Ala His Arg Asn Tyr Ser Glu 
            580                 585                 590         


Ser Phe Phe Glu Ala Ala Ser Met Met Ser Lys Leu Ser His Lys His 
        595                 600                 605             


Leu Val Leu Asn Tyr Gly Val Cys Val Cys Gly Asp Glu Asn Ile Leu 
    610                 615                 620                 


Val Gln Glu Phe Val Lys Phe Gly Ser Leu Asp Thr Tyr Leu Lys Lys 
625                 630                 635                 640 


Asn Lys Asn Cys Ile Asn Ile Leu Trp Lys Leu Glu Val Ala Lys Gln 
                645                 650                 655     


Leu Ala Trp Ala Met His Phe Leu Glu Glu Asn Thr Leu Ile His Gly 
            660                 665                 670         


Asn Val Cys Ala Lys Asn Ile Leu Leu Ile Arg Glu Glu Asp Arg Lys 
        675                 680                 685             


Thr Gly Asn Pro Pro Phe Ile Lys Leu Ser Asp Pro Gly Ile Ser Ile 
    690                 695                 700                 


Thr Val Leu Pro Lys Asp Ile Leu Gln Glu Arg Ile Pro Trp Val Pro 
705                 710                 715                 720 


Pro Glu Cys Ile Glu Asn Pro Lys Asn Leu Asn Leu Ala Thr Asp Lys 
                725                 730                 735     


Trp Ser Phe Gly Thr Thr Leu Trp Glu Ile Cys Ser Gly Gly Asp Lys 
            740                 745                 750         


Pro Leu Ser Ala Leu Asp Ser Gln Arg Lys Leu Gln Phe Tyr Glu Asp 
        755                 760                 765             


Arg His Gln Leu Pro Ala Pro Lys Trp Ala Glu Leu Ala Asn Leu Ile 
    770                 775                 780                 


Asn Asn Cys Met Asp Tyr Glu Pro Asp Phe Arg Pro Ser Phe Arg Ala 
785                 790                 795                 800 


Ile Ile Arg Asp Leu Asn Ser Leu Phe Thr Pro Asp Tyr Glu Leu Leu 
                805                 810                 815     


Thr Glu Asn Asp Met Leu Pro Asn Met Arg Ile Gly Ala Leu Gly Phe 
            820                 825                 830         


Ser Gly Ala Phe Glu Asp Arg Asp Pro Thr Gln Phe Glu Glu Arg His 
        835                 840                 845             


Leu Lys Phe Leu Gln Gln Leu Gly Lys Gly Asn Phe Gly Ser Val Glu 
    850                 855                 860                 


Met Cys Arg Tyr Asp Pro Leu Gln Asp Asn Thr Gly Glu Val Val Ala 
865                 870                 875                 880 


Val Lys Lys Leu Gln His Ser Thr Glu Glu His Leu Arg Asp Phe Glu 
                885                 890                 895     


Arg Glu Ile Glu Ile Leu Lys Ser Leu Gln His Asp Asn Ile Val Lys 
            900                 905                 910         


Tyr Lys Gly Val Cys Tyr Ser Ala Gly Arg Arg Asn Leu Lys Leu Ile 
        915                 920                 925             


Met Glu Tyr Leu Pro Tyr Gly Ser Leu Arg Asp Tyr Leu Gln Lys His 
    930                 935                 940                 


Lys Glu Arg Ile Asp His Ile Lys Leu Leu Gln Tyr Thr Ser Gln Ile 
945                 950                 955                 960 


Cys Lys Gly Met Glu Tyr Leu Gly Thr Lys Arg Tyr Ile His Arg Asp 
                965                 970                 975     


Leu Ala Thr Arg Asn Ile Leu Val Glu Asn Glu Asn Arg Val Lys Ile 
            980                 985                 990         


Gly Asp Phe Gly Leu Thr Lys Val  Leu Pro Gln Asp Lys  Glu Tyr Tyr 
        995                 1000                 1005             


Lys Val  Lys Glu Pro Gly Glu  Ser Pro Ile Phe Trp  Tyr Ala Pro 
    1010                 1015                 1020             


Glu Ser  Leu Thr Glu Ser Lys  Phe Ser Val Ala Ser  Asp Val Trp 
    1025                 1030                 1035             


Ser Phe  Gly Val Val Leu Tyr  Glu Leu Phe Thr Tyr  Ile Glu Lys 
    1040                 1045                 1050             


Ser Lys  Ser Pro Pro Ala Glu  Phe Met Arg Met Ile  Gly Asn Asp 
    1055                 1060                 1065             


Lys Gln  Gly Gln Met Ile Val  Phe His Leu Ile Glu  Leu Leu Lys 
    1070                 1075                 1080             


Asn Asn  Gly Arg Leu Pro Arg  Pro Asp Gly Cys Pro  Asp Glu Ile 
    1085                 1090                 1095             


Tyr Met  Ile Met Thr Glu Cys  Trp Asn Asn Asn Val  Asn Gln Arg 
    1100                 1105                 1110             


Pro Ser  Phe Arg Asp Leu Ala  Leu Arg Val Asp Gln  Ile Arg Asp 
    1115                 1120                 1125             


Asn Met  Ala Gly 
    1130         


<210>  22
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  biotinylated pUL53-hook peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal acetyl

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal 8-amino-3,6-dioxaoctanoic acid-Lys(Biotin)-NH2

<400>  22

Leu Thr Leu His Asp Leu His Asp Ile Phe Arg Glu His Pro Glu Leu 
1               5                   10                  15      


Glu Leu Lys Tyr Leu Asn Met Met Lys Met Ala Ile Thr 
            20                  25                  


<210>  23
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  part 1 of detection mix for DNA hydrolase activity


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  8-oxoA, 5'-fluorescein

<400>  23
tctgccacac tgcgtcgacc tg                                                22


<210>  24
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  part 2 of detection mix for DNA hydrolase activity


<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  3'-dabcyl

<400>  24
caggtcgacg cagtgctggc agt                                               23


<210>  25
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  detector for kinase-phosphatase activity

<400>  25

Gly Pro Arg Ser Pro Ser Tyr Gly Arg Ser Arg Ser Arg Ser Arg Ser 
1               5                   10                  15      


Arg Ser Arg Ser Arg Ser Arg Ser Asn Ser Arg Ser Arg Ser Tyr Ser 
            20                  25                  30          


<210>  26
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer for NgTAL gene

<400>  26
ggtatgacca ttctgagtga tg                                                22


<210>  27
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer for NgTAL gene

<400>  27
ttaaaccagc ggtgccagc                                                    19


<210>  28
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer for Lys8Ala mutagenesis of NgTAL

<400>  28
gagtgatgtt gcagcactgg gtcagc                                            26


<210>  29
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer for Lys8Ala mutagenesis of NgTAL

<400>  29
gctgacccag tgctgcaaca tcactc                                            26


<210>  30
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer for Cys38Ser mutagenesis of NgTAL

<400>  30
gctgaaacag ggtgtttctg gtgttaccag c                                      31


<210>  31
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer for Cys38Ser mutagenesis of NgTAL

<400>  31
gctggtaaca ccagaaacac cctgtttcag c                                      31


<210>  32
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer for Cys87Ala mutagenesis of NgTAL

<400>  32
cgtgcagcag ctgatgtttg tctgg                                             25


<210>  33
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer for Cys87Ala mutagenesis of NgTAL

<400>  33
ccagacaaac atcagctgct gcacg                                             25


<210>  34
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer for Cys90Ala mutagenesis of NgTAL

<400>  34
gcatgtgatg ttgctctggc agaacatgaa agc                                    33


<210>  35
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer for Cys90Ala mutagenesis of NgTAL

<400>  35
gctttcatgt tctgccagag caacatcaca tgc                                    33


<210>  36
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neisseria gonnorhoeae transaldolase with N-terminal G

<400>  36

Gly Met Thr Ile Leu Ser Asp Val Lys Ala Leu Gly Gln Gln Ile Trp 
1               5                   10                  15      


Leu Asp Asn Leu Ser Arg Ser Leu Val Gln Ser Gly Glu Leu Ala Gln 
            20                  25                  30          


Met Leu Lys Gln Gly Val Cys Gly Val Thr Ser Asn Pro Ala Ile Phe 
        35                  40                  45              


Gln Lys Ala Phe Ala Gly Asp Ala Leu Tyr Ala Asp Glu Val Ala Ala 
    50                  55                  60                  


Leu Lys Arg Gln Asn Leu Ser Pro Lys Gln Arg Tyr Glu Thr Met Ala 
65                  70                  75                  80  


Val Ala Asp Val Arg Ala Ala Cys Asp Val Cys Leu Ala Glu His Glu 
                85                  90                  95      


Ser Thr Gly Gly Lys Thr Gly Phe Val Ser Leu Glu Val Ser Pro Glu 
            100                 105                 110         


Leu Ala Lys Asp Ala Gln Gly Thr Val Glu Glu Ala Arg Arg Leu His 
        115                 120                 125             


Ala Ala Ile Ala Arg Lys Asn Ala Met Ile Lys Val Pro Ala Thr Asp 
    130                 135                 140                 


Ala Gly Ile Asp Ala Leu Glu Thr Leu Val Ser Asp Gly Ile Ser Val 
145                 150                 155                 160 


Asn Leu Thr Leu Leu Phe Ser Arg Ala Gln Thr Leu Lys Ala Tyr Ala 
                165                 170                 175     


Ala Tyr Ala Arg Gly Ile Ala Lys Arg Leu Ala Ala Gly Gln Ser Val 
            180                 185                 190         


Ala His Ile Gln Val Val Ala Ser Phe Phe Ile Ser Arg Val Asp Ser 
        195                 200                 205             


Ala Leu Asp Ala Thr Leu Pro Asp Arg Leu Lys Gly Lys Thr Ala Ile 
    210                 215                 220                 


Ala Leu Ala Lys Ala Ala Tyr Gln Asp Trp Glu Gln Tyr Phe Thr Ala 
225                 230                 235                 240 


Pro Glu Phe Ala Ala Leu Glu Ala Gln Gly Ala Asn Arg Val Gln Leu 
                245                 250                 255     


Leu Trp Ala Ser Thr Gly Val Lys Asn Pro Ala Tyr Pro Asp Thr Leu 
            260                 265                 270         


Tyr Val Asp Ser Leu Ile Gly Val His Thr Val Asn Thr Val Pro Asp 
        275                 280                 285             


Ala Thr Leu Lys Ala Phe Ile Asp His Gly Thr Ala Lys Ala Thr Leu 
    290                 295                 300                 


Thr Glu Ser Ala Asp Glu Ala Arg Ala Arg Leu Ala Glu Ile Ala Ala 
305                 310                 315                 320 


Leu Gly Ile Asp Val Glu Thr Leu Ala Ala Arg Leu Gln Glu Asp Gly 
                325                 330                 335     


Leu Lys Gln Phe Glu Glu Ala Phe Glu Lys Leu Leu Ala Pro Leu Val 
            340                 345                 350         


<210>  37
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neisseria gonnorhoeae transaldolase Lys8Ala variant with 
       N-terminal G

<400>  37

Gly Met Thr Ile Leu Ser Asp Val Ala Ala Leu Gly Gln Gln Ile Trp 
1               5                   10                  15      


Leu Asp Asn Leu Ser Arg Ser Leu Val Gln Ser Gly Glu Leu Ala Gln 
            20                  25                  30          


Met Leu Lys Gln Gly Val Cys Gly Val Thr Ser Asn Pro Ala Ile Phe 
        35                  40                  45              


Gln Lys Ala Phe Ala Gly Asp Ala Leu Tyr Ala Asp Glu Val Ala Ala 
    50                  55                  60                  


Leu Lys Arg Gln Asn Leu Ser Pro Lys Gln Arg Tyr Glu Thr Met Ala 
65                  70                  75                  80  


Val Ala Asp Val Arg Ala Ala Cys Asp Val Cys Leu Ala Glu His Glu 
                85                  90                  95      


Ser Thr Gly Gly Lys Thr Gly Phe Val Ser Leu Glu Val Ser Pro Glu 
            100                 105                 110         


Leu Ala Lys Asp Ala Gln Gly Thr Val Glu Glu Ala Arg Arg Leu His 
        115                 120                 125             


Ala Ala Ile Ala Arg Lys Asn Ala Met Ile Lys Val Pro Ala Thr Asp 
    130                 135                 140                 


Ala Gly Ile Asp Ala Leu Glu Thr Leu Val Ser Asp Gly Ile Ser Val 
145                 150                 155                 160 


Asn Leu Thr Leu Leu Phe Ser Arg Ala Gln Thr Leu Lys Ala Tyr Ala 
                165                 170                 175     


Ala Tyr Ala Arg Gly Ile Ala Lys Arg Leu Ala Ala Gly Gln Ser Val 
            180                 185                 190         


Ala His Ile Gln Val Val Ala Ser Phe Phe Ile Ser Arg Val Asp Ser 
        195                 200                 205             


Ala Leu Asp Ala Thr Leu Pro Asp Arg Leu Lys Gly Lys Thr Ala Ile 
    210                 215                 220                 


Ala Leu Ala Lys Ala Ala Tyr Gln Asp Trp Glu Gln Tyr Phe Thr Ala 
225                 230                 235                 240 


Pro Glu Phe Ala Ala Leu Glu Ala Gln Gly Ala Asn Arg Val Gln Leu 
                245                 250                 255     


Leu Trp Ala Ser Thr Gly Val Lys Asn Pro Ala Tyr Pro Asp Thr Leu 
            260                 265                 270         


Tyr Val Asp Ser Leu Ile Gly Val His Thr Val Asn Thr Val Pro Asp 
        275                 280                 285             


Ala Thr Leu Lys Ala Phe Ile Asp His Gly Thr Ala Lys Ala Thr Leu 
    290                 295                 300                 


Thr Glu Ser Ala Asp Glu Ala Arg Ala Arg Leu Ala Glu Ile Ala Ala 
305                 310                 315                 320 


Leu Gly Ile Asp Val Glu Thr Leu Ala Ala Arg Leu Gln Glu Asp Gly 
                325                 330                 335     


Leu Lys Gln Phe Glu Glu Ala Phe Glu Lys Leu Leu Ala Pro Leu Val 
            340                 345                 350         


<210>  38
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neisseria gonnorhoeae transaldolase Cys38Ser variant with 
       N-terminal G

<400>  38

Gly Met Thr Ile Leu Ser Asp Val Lys Ala Leu Gly Gln Gln Ile Trp 
1               5                   10                  15      


Leu Asp Asn Leu Ser Arg Ser Leu Val Gln Ser Gly Glu Leu Ala Gln 
            20                  25                  30          


Met Leu Lys Gln Gly Val Ser Gly Val Thr Ser Asn Pro Ala Ile Phe 
        35                  40                  45              


Gln Lys Ala Phe Ala Gly Asp Ala Leu Tyr Ala Asp Glu Val Ala Ala 
    50                  55                  60                  


Leu Lys Arg Gln Asn Leu Ser Pro Lys Gln Arg Tyr Glu Thr Met Ala 
65                  70                  75                  80  


Val Ala Asp Val Arg Ala Ala Cys Asp Val Cys Leu Ala Glu His Glu 
                85                  90                  95      


Ser Thr Gly Gly Lys Thr Gly Phe Val Ser Leu Glu Val Ser Pro Glu 
            100                 105                 110         


Leu Ala Lys Asp Ala Gln Gly Thr Val Glu Glu Ala Arg Arg Leu His 
        115                 120                 125             


Ala Ala Ile Ala Arg Lys Asn Ala Met Ile Lys Val Pro Ala Thr Asp 
    130                 135                 140                 


Ala Gly Ile Asp Ala Leu Glu Thr Leu Val Ser Asp Gly Ile Ser Val 
145                 150                 155                 160 


Asn Leu Thr Leu Leu Phe Ser Arg Ala Gln Thr Leu Lys Ala Tyr Ala 
                165                 170                 175     


Ala Tyr Ala Arg Gly Ile Ala Lys Arg Leu Ala Ala Gly Gln Ser Val 
            180                 185                 190         


Ala His Ile Gln Val Val Ala Ser Phe Phe Ile Ser Arg Val Asp Ser 
        195                 200                 205             


Ala Leu Asp Ala Thr Leu Pro Asp Arg Leu Lys Gly Lys Thr Ala Ile 
    210                 215                 220                 


Ala Leu Ala Lys Ala Ala Tyr Gln Asp Trp Glu Gln Tyr Phe Thr Ala 
225                 230                 235                 240 


Pro Glu Phe Ala Ala Leu Glu Ala Gln Gly Ala Asn Arg Val Gln Leu 
                245                 250                 255     


Leu Trp Ala Ser Thr Gly Val Lys Asn Pro Ala Tyr Pro Asp Thr Leu 
            260                 265                 270         


Tyr Val Asp Ser Leu Ile Gly Val His Thr Val Asn Thr Val Pro Asp 
        275                 280                 285             


Ala Thr Leu Lys Ala Phe Ile Asp His Gly Thr Ala Lys Ala Thr Leu 
    290                 295                 300                 


Thr Glu Ser Ala Asp Glu Ala Arg Ala Arg Leu Ala Glu Ile Ala Ala 
305                 310                 315                 320 


Leu Gly Ile Asp Val Glu Thr Leu Ala Ala Arg Leu Gln Glu Asp Gly 
                325                 330                 335     


Leu Lys Gln Phe Glu Glu Ala Phe Glu Lys Leu Leu Ala Pro Leu Val 
            340                 345                 350         


<210>  39
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neisseria gonnorhoeae transaldolase N-terminal motif

<400>  39

Met Thr Ile Leu Ser Asp Val Lys Ala Leu Gly Gln Gln Ile Trp Leu 
1               5                   10                  15      


Asp Asn Leu Ser Arg Ser Leu Val Gln Ser Gly Glu Leu Ala Gln Met 
            20                  25                  30          


Leu Lys Gln Gly Val Cys Gly Val Thr Ser Asn Pro Ala Ile Phe 
        35                  40                  45          


<210>  40
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neisseria meningitidis transaldolase N-terminal motif

<400>  40

Met Thr Ile Leu Ser Asp Val Lys Ala Leu Gly Gln Gln Ile Trp Leu 
1               5                   10                  15      


Asp Asn Leu Ser Arg Ser Leu Val Gln Ser Gly Glu Leu Ala Gln Met 
            20                  25                  30          


Leu Lys Gln Gly Val Cys Gly Val Thr Ser Asn Pro Ala Ile Phe 
        35                  40                  45          


<210>  41
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neisseria transaldolase N-terminal consensus motif 1

<400>  41

Met Thr Ile Leu Ser Asp Val Lys Ala Leu Gly Gln Gln Ile Trp Leu 
1               5                   10                  15      


Asp Asn Leu Ser Arg Ser Leu Val Gln Ser Gly Glu Leu Ala Pro Met 
            20                  25                  30          


Leu Pro Gln Gly Val Cys Gly Val Thr Ser Asn Pro Ala Ile Phe 
        35                  40                  45          


<210>  42
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neisseria transaldolase N-terminal consensus motif 2

<400>  42

Thr Asn Pro Leu Leu Glu Ile Lys Pro Tyr Gly Gln Ser Ile Trp Met 
1               5                   10                  15      


Asp Asn Leu Pro Arg Asp Ile Ile Pro Ser Gly Glu Leu Lys Pro Leu 
            20                  25                  30          


Val Glu Asn Pro Gly Ile Cys Gly Ile Thr Ser Asn Pro Ser Ile Phe 
        35                  40                  45              


