                         SEQUENCE LISTING

<110>  VIB VZW
       KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D
 
<120>  NEK6 INHIBITION TO TREAT ALS AND FTD

<130>  LVDB/NEK6/721

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Gly Gln Pro Gly His Met Pro His Gly Gly Ser Ser Asn Asn 
1               5                   10                  15      


Leu Cys His Thr Leu Gly Pro Val His Pro Pro Asp Pro Gln Arg His 
            20                  25                  30          


Pro Asn Thr Leu Ser Phe Arg Cys Ser Leu Ala Asp Phe Gln Ile Glu 
        35                  40                  45              


Lys Lys Ile Gly Arg Gly Gln Phe Ser Glu Val Tyr Lys Ala Thr Cys 
    50                  55                  60                  


Leu Leu Asp Arg Lys Thr Val Ala Leu Lys Lys Val Gln Ile Phe Glu 
65                  70                  75                  80  


Met Met Asp Ala Lys Ala Arg Gln Asp Cys Val Lys Glu Ile Gly Leu 
                85                  90                  95      


Leu Lys Gln Leu Asn His Pro Asn Ile Ile Lys Tyr Leu Asp Ser Phe 
            100                 105                 110         


Ile Glu Asp Asn Glu Leu Asn Ile Val Leu Glu Leu Ala Asp Ala Gly 
        115                 120                 125             


Asp Leu Ser Gln Met Ile Lys Tyr Phe Lys Lys Gln Lys Arg Leu Ile 
    130                 135                 140                 


Pro Glu Arg Thr Val Trp Lys Tyr Phe Val Gln Leu Cys Ser Ala Val 
145                 150                 155                 160 


Glu His Met His Ser Arg Arg Val Met His Arg Asp Ile Lys Pro Ala 
                165                 170                 175     


Asn Val Phe Ile Thr Ala Thr Gly Val Val Lys Leu Gly Asp Leu Gly 
            180                 185                 190         


Leu Gly Arg Phe Phe Ser Ser Glu Thr Thr Ala Ala His Ser Leu Val 
        195                 200                 205             


Gly Thr Pro Tyr Tyr Met Ser Pro Glu Arg Ile His Glu Asn Gly Tyr 
    210                 215                 220                 


Asn Phe Lys Ser Asp Ile Trp Ser Leu Gly Cys Leu Leu Tyr Glu Met 
225                 230                 235                 240 


Ala Ala Leu Gln Ser Pro Phe Tyr Gly Asp Lys Met Asn Leu Phe Ser 
                245                 250                 255     


Leu Cys Gln Lys Ile Glu Gln Cys Asp Tyr Pro Pro Leu Pro Gly Glu 
            260                 265                 270         


His Tyr Ser Glu Lys Leu Arg Glu Leu Val Ser Met Cys Ile Cys Pro 
        275                 280                 285             


Asp Pro His Gln Arg Pro Asp Ile Gly Tyr Val His Gln Val Ala Lys 
    290                 295                 300                 


Gln Met His Ile Trp Met Ser Ser Thr 
305                 310             


<210>  2
<211>  765
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Gly Phe Lys Arg Gly Tyr Asp Gly Lys Ile Ala Gly Leu Tyr 
1               5                   10                  15      


Asp Leu Asp Lys Thr Leu Gly Arg Gly His Phe Ala Val Val Lys Leu 
            20                  25                  30          


Ala Arg His Val Phe Thr Gly Glu Lys Val Ala Val Lys Val Ile Asp 
        35                  40                  45              


Lys Thr Lys Leu Asp Thr Leu Ala Thr Gly His Leu Phe Gln Glu Val 
    50                  55                  60                  


Arg Cys Met Lys Leu Val Gln His Pro Asn Ile Val Arg Leu Tyr Glu 
65                  70                  75                  80  


Val Ile Asp Thr Gln Thr Lys Leu Tyr Leu Ile Leu Glu Leu Gly Asp 
                85                  90                  95      


Gly Gly Asp Met Phe Asp Tyr Ile Met Lys His Glu Glu Gly Leu Asn 
            100                 105                 110         


Glu Asp Leu Ala Lys Lys Tyr Phe Ala Gln Ile Val His Ala Ile Ser 
        115                 120                 125             


Tyr Cys His Lys Leu His Val Val His Arg Asp Leu Lys Pro Glu Asn 
    130                 135                 140                 


Val Val Phe Phe Glu Lys Gln Gly Leu Val Lys Leu Thr Asp Phe Gly 
145                 150                 155                 160 


Phe Ser Asn Lys Phe Gln Pro Gly Lys Lys Leu Thr Thr Ser Cys Gly 
                165                 170                 175     


Ser Leu Ala Tyr Ser Ala Pro Glu Ile Leu Leu Gly Asp Glu Tyr Asp 
            180                 185                 190         


Ala Pro Ala Val Asp Ile Trp Ser Leu Gly Val Ile Leu Phe Met Leu 
        195                 200                 205             


Val Cys Gly Gln Pro Pro Phe Gln Glu Ala Asn Asp Ser Glu Thr Leu 
    210                 215                 220                 


Thr Met Ile Met Asp Cys Lys Tyr Thr Val Pro Ser His Val Ser Lys 
225                 230                 235                 240 


Glu Cys Lys Asp Leu Ile Thr Arg Met Leu Gln Arg Asp Pro Lys Arg 
                245                 250                 255     


Arg Ala Ser Leu Glu Glu Ile Glu Asn His Pro Trp Leu Gln Gly Val 
            260                 265                 270         


Asp Pro Ser Pro Ala Thr Lys Tyr Asn Ile Pro Leu Val Ser Tyr Lys 
        275                 280                 285             


Asn Leu Ser Glu Glu Glu His Asn Ser Ile Ile Gln Arg Met Val Leu 
    290                 295                 300                 


Gly Asp Ile Ala Asp Arg Asp Ala Ile Val Glu Ala Leu Glu Thr Asn 
305                 310                 315                 320 


Arg Tyr Asn His Ile Thr Ala Thr Tyr Phe Leu Leu Ala Glu Arg Ile 
                325                 330                 335     


Leu Arg Glu Lys Gln Glu Lys Glu Ile Gln Thr Arg Ser Ala Ser Pro 
            340                 345                 350         


Ser Asn Ile Lys Ala Gln Phe Arg Gln Ser Trp Pro Thr Lys Ile Asp 
        355                 360                 365             


Val Pro Gln Asp Leu Glu Asp Asp Leu Thr Ala Thr Pro Leu Ser His 
    370                 375                 380                 


Ala Thr Val Pro Gln Ser Pro Ala Arg Ala Ala Asp Ser Val Leu Asn 
385                 390                 395                 400 


Gly His Arg Ser Lys Gly Leu Cys Asp Ser Ala Lys Lys Asp Asp Leu 
                405                 410                 415     


Pro Glu Leu Ala Gly Pro Ala Leu Ser Thr Val Pro Pro Ala Ser Leu 
            420                 425                 430         


Lys Pro Thr Ala Ser Gly Arg Lys Cys Leu Phe Arg Val Glu Glu Asp 
        435                 440                 445             


Glu Glu Glu Asp Glu Glu Asp Lys Lys Pro Met Ser Leu Ser Thr Gln 
    450                 455                 460                 


Val Val Leu Arg Arg Lys Pro Ser Val Thr Asn Arg Leu Thr Ser Arg 
465                 470                 475                 480 


Lys Ser Ala Pro Val Leu Asn Gln Ile Phe Glu Glu Gly Glu Ser Asp 
                485                 490                 495     


Asp Glu Phe Asp Met Asp Glu Asn Leu Pro Pro Lys Leu Ser Arg Leu 
            500                 505                 510         


Lys Met Asn Ile Ala Ser Pro Gly Thr Val His Lys Arg Tyr His Arg 
        515                 520                 525             


Arg Lys Ser Gln Gly Arg Gly Ser Ser Cys Ser Ser Ser Glu Thr Ser 
    530                 535                 540                 


Asp Asp Asp Ser Glu Ser Arg Arg Arg Leu Asp Lys Asp Ser Gly Phe 
545                 550                 555                 560 


Thr Tyr Ser Trp His Arg Arg Asp Ser Ser Glu Gly Pro Pro Gly Ser 
                565                 570                 575     


Glu Gly Asp Gly Gly Gly Gln Ser Lys Pro Ser Asn Ala Ser Gly Gly 
            580                 585                 590         


Val Asp Lys Ala Ser Pro Ser Glu Asn Asn Ala Gly Gly Gly Ser Pro 
        595                 600                 605             


Ser Ser Gly Ser Gly Gly Asn Pro Thr Asn Thr Ser Gly Thr Thr Arg 
    610                 615                 620                 


Arg Cys Ala Gly Pro Ser Asn Ser Met Gln Leu Ala Ser Arg Ser Ala 
625                 630                 635                 640 


Gly Glu Leu Val Glu Ser Leu Lys Leu Met Ser Leu Cys Leu Gly Ser 
                645                 650                 655     


Gln Leu His Gly Ser Thr Lys Tyr Ile Ile Asp Pro Gln Asn Gly Leu 
            660                 665                 670         


Ser Phe Ser Ser Val Lys Val Gln Glu Lys Ser Thr Trp Lys Met Cys 
        675                 680                 685             


Ile Ser Ser Thr Gly Asn Ala Gly Gln Val Pro Ala Val Gly Gly Ile 
    690                 695                 700                 


Lys Phe Phe Ser Asp His Met Ala Asp Thr Thr Thr Glu Leu Glu Arg 
705                 710                 715                 720 


Ile Lys Ser Lys Asn Leu Lys Asn Asn Val Leu Gln Leu Pro Leu Cys 
                725                 730                 735     


Glu Lys Thr Ile Ser Val Asn Ile Gln Arg Asn Pro Lys Glu Gly Leu 
            740                 745                 750         


Leu Cys Ala Ser Ser Pro Ala Ser Cys Cys His Val Ile 
        755                 760                 765 


<210>  3
<211>  1258
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Lys Tyr Val Arg Leu Gln Lys Ile Gly Glu Gly Ser Phe Gly 
1               5                   10                  15      


Lys Ala Ile Leu Val Lys Ser Thr Glu Asp Gly Arg Gln Tyr Val Ile 
            20                  25                  30          


Lys Glu Ile Asn Ile Ser Arg Met Ser Ser Lys Glu Arg Glu Glu Ser 
        35                  40                  45              


Arg Arg Glu Val Ala Val Leu Ala Asn Met Lys His Pro Asn Ile Val 
    50                  55                  60                  


Gln Tyr Arg Glu Ser Phe Glu Glu Asn Gly Ser Leu Tyr Ile Val Met 
65                  70                  75                  80  


Asp Tyr Cys Glu Gly Gly Asp Leu Phe Lys Arg Ile Asn Ala Gln Lys 
                85                  90                  95      


Gly Val Leu Phe Gln Glu Asp Gln Ile Leu Asp Trp Phe Val Gln Ile 
            100                 105                 110         


Cys Leu Ala Leu Lys His Val His Asp Arg Lys Ile Leu His Arg Asp 
        115                 120                 125             


Ile Lys Ser Gln Asn Ile Phe Leu Thr Lys Asp Gly Thr Val Gln Leu 
    130                 135                 140                 


Gly Asp Phe Gly Ile Ala Arg Val Leu Asn Ser Thr Val Glu Leu Ala 
145                 150                 155                 160 


Arg Thr Cys Ile Gly Thr Pro Tyr Tyr Leu Ser Pro Glu Ile Cys Glu 
                165                 170                 175     


Asn Lys Pro Tyr Asn Asn Lys Ser Asp Ile Trp Ala Leu Gly Cys Val 
            180                 185                 190         


Leu Tyr Glu Leu Cys Thr Leu Lys His Ala Phe Glu Ala Gly Ser Met 
        195                 200                 205             


Lys Asn Leu Val Leu Lys Ile Ile Ser Gly Ser Phe Pro Pro Val Ser 
    210                 215                 220                 


Leu His Tyr Ser Tyr Asp Leu Arg Ser Leu Val Ser Gln Leu Phe Lys 
225                 230                 235                 240 


Arg Asn Pro Arg Asp Arg Pro Ser Val Asn Ser Ile Leu Glu Lys Gly 
                245                 250                 255     


Phe Ile Ala Lys Arg Ile Glu Lys Phe Leu Ser Pro Gln Leu Ile Ala 
            260                 265                 270         


Glu Glu Phe Cys Leu Lys Thr Phe Ser Lys Phe Gly Ser Gln Pro Ile 
        275                 280                 285             


Pro Ala Lys Arg Pro Ala Ser Gly Gln Asn Ser Ile Ser Val Met Pro 
    290                 295                 300                 


Ala Gln Lys Ile Thr Lys Pro Ala Ala Lys Tyr Gly Ile Pro Leu Ala 
305                 310                 315                 320 


Tyr Lys Lys Tyr Gly Asp Lys Lys Leu His Glu Lys Lys Pro Leu Gln 
                325                 330                 335     


Lys His Lys Gln Ala His Gln Thr Pro Glu Lys Arg Val Asn Thr Gly 
            340                 345                 350         


Glu Glu Arg Arg Lys Ile Ser Glu Glu Ala Ala Arg Lys Arg Arg Leu 
        355                 360                 365             


Glu Phe Ile Glu Lys Glu Lys Lys Gln Lys Asp Gln Ile Ile Ser Leu 
    370                 375                 380                 


Met Lys Ala Glu Gln Met Lys Arg Gln Glu Lys Glu Arg Leu Glu Arg 
385                 390                 395                 400 


Ile Asn Arg Ala Arg Glu Gln Gly Trp Arg Asn Val Leu Ser Ala Gly 
                405                 410                 415     


Gly Ser Gly Glu Val Lys Ala Pro Phe Leu Gly Ser Gly Gly Thr Ile 
            420                 425                 430         


Ala Pro Ser Ser Phe Ser Ser Arg Gly Gln Tyr Glu His Tyr His Ala 
        435                 440                 445             


Ile Phe Asp Gln Met Gln Gln Gln Arg Ala Glu Asp Asn Glu Ala Lys 
    450                 455                 460                 


Trp Lys Arg Glu Ile Tyr Gly Arg Gly Leu Pro Glu Arg Gly Ile Leu 
465                 470                 475                 480 


Pro Gly Val Arg Pro Gly Phe Pro Tyr Gly Ala Ala Gly His His His 
                485                 490                 495     


Phe Pro Asp Ala Asp Asp Ile Arg Lys Thr Leu Lys Arg Leu Lys Ala 
            500                 505                 510         


Val Ser Lys Gln Ala Asn Ala Asn Arg Gln Lys Gly Gln Leu Ala Val 
        515                 520                 525             


Glu Arg Ala Lys Gln Val Glu Glu Phe Leu Gln Arg Lys Arg Glu Ala 
    530                 535                 540                 


Met Gln Asn Lys Ala Arg Ala Glu Gly His Met Val Tyr Leu Ala Arg 
545                 550                 555                 560 


Leu Arg Gln Ile Arg Leu Gln Asn Phe Asn Glu Arg Gln Gln Ile Lys 
                565                 570                 575     


Ala Lys Leu Arg Gly Glu Lys Lys Glu Ala Asn His Ser Glu Gly Gln 
            580                 585                 590         


Glu Gly Ser Glu Glu Ala Asp Met Arg Arg Lys Lys Ile Glu Ser Leu 
        595                 600                 605             


Lys Ala His Ala Asn Ala Arg Ala Ala Val Leu Lys Glu Gln Leu Glu 
    610                 615                 620                 


Arg Lys Arg Lys Glu Ala Tyr Glu Arg Glu Lys Lys Val Trp Glu Glu 
625                 630                 635                 640 


His Leu Val Ala Lys Gly Val Lys Ser Ser Asp Val Ser Pro Pro Leu 
                645                 650                 655     


Gly Gln His Glu Thr Gly Gly Ser Pro Ser Lys Gln Gln Met Arg Ser 
            660                 665                 670         


Val Ile Ser Val Thr Ser Ala Leu Lys Glu Val Gly Val Asp Ser Ser 
        675                 680                 685             


Leu Thr Asp Thr Arg Glu Thr Ser Glu Glu Met Gln Lys Thr Asn Asn 
    690                 695                 700                 


Ala Ile Ser Ser Lys Arg Glu Ile Leu Arg Arg Leu Asn Glu Asn Leu 
705                 710                 715                 720 


Lys Ala Gln Glu Asp Glu Lys Gly Lys Gln Asn Leu Ser Asp Thr Phe 
                725                 730                 735     


Glu Ile Asn Val His Glu Asp Ala Lys Glu His Glu Lys Glu Lys Ser 
            740                 745                 750         


Val Ser Ser Asp Arg Lys Lys Trp Glu Ala Gly Gly Gln Leu Val Ile 
        755                 760                 765             


Pro Leu Asp Glu Leu Thr Leu Asp Thr Ser Phe Ser Thr Thr Glu Arg 
    770                 775                 780                 


His Thr Val Gly Glu Val Ile Lys Leu Gly Pro Asn Gly Ser Pro Arg 
785                 790                 795                 800 


Arg Ala Trp Gly Lys Ser Pro Thr Asp Ser Val Leu Lys Ile Leu Gly 
                805                 810                 815     


Glu Ala Glu Leu Gln Leu Gln Thr Glu Leu Leu Glu Asn Thr Thr Ile 
            820                 825                 830         


Arg Ser Glu Ile Ser Pro Glu Gly Glu Lys Tyr Lys Pro Leu Ile Thr 
        835                 840                 845             


Gly Glu Lys Lys Val Gln Cys Ile Ser His Glu Ile Asn Pro Ser Ala 
    850                 855                 860                 


Ile Val Asp Ser Pro Val Glu Thr Lys Ser Pro Glu Phe Ser Glu Ala 
865                 870                 875                 880 


Ser Pro Gln Met Ser Leu Lys Leu Glu Gly Asn Leu Glu Glu Pro Asp 
                885                 890                 895     


Asp Leu Glu Thr Glu Ile Leu Gln Glu Pro Ser Gly Thr Asn Lys Asp 
            900                 905                 910         


Glu Ser Leu Pro Cys Thr Ile Thr Asp Val Trp Ile Ser Glu Glu Lys 
        915                 920                 925             


Glu Thr Lys Glu Thr Gln Ser Ala Asp Arg Ile Thr Ile Gln Glu Asn 
    930                 935                 940                 


Glu Val Ser Glu Asp Gly Val Ser Ser Thr Val Asp Gln Leu Ser Asp 
945                 950                 955                 960 


Ile His Ile Glu Pro Gly Thr Asn Asp Ser Gln His Ser Lys Cys Asp 
                965                 970                 975     


Val Asp Lys Ser Val Gln Pro Glu Pro Phe Phe His Lys Val Val His 
            980                 985                 990         


Ser Glu His Leu Asn Leu Val Pro  Gln Val Gln Ser Val  Gln Cys Ser 
        995                 1000                 1005             


Pro Glu  Glu Ser Phe Ala Phe  Arg Ser His Ser His  Leu Pro Pro 
    1010                 1015                 1020             


Lys Asn  Lys Asn Lys Asn Ser  Leu Leu Ile Gly Leu  Ser Thr Gly 
    1025                 1030                 1035             


Leu Phe  Asp Ala Asn Asn Pro  Lys Met Leu Arg Thr  Cys Ser Leu 
    1040                 1045                 1050             


Pro Asp  Leu Ser Lys Leu Phe  Arg Thr Leu Met Asp  Val Pro Thr 
    1055                 1060                 1065             


Val Gly  Asp Val Arg Gln Asp  Asn Leu Glu Ile Asp  Glu Ile Glu 
    1070                 1075                 1080             


Asp Glu  Asn Ile Lys Glu Gly  Pro Ser Asp Ser Glu  Asp Ile Val 
    1085                 1090                 1095             


Phe Glu  Glu Thr Asp Thr Asp  Leu Gln Glu Leu Gln  Ala Ser Met 
    1100                 1105                 1110             


Glu Gln  Leu Leu Arg Glu Gln  Pro Gly Glu Glu Tyr  Ser Glu Glu 
    1115                 1120                 1125             


Glu Glu  Ser Val Leu Lys Asn  Ser Asp Val Glu Pro  Thr Ala Asn 
    1130                 1135                 1140             


Gly Thr  Asp Val Ala Asp Glu  Asp Asp Asn Pro Ser  Ser Glu Ser 
    1145                 1150                 1155             


Ala Leu  Asn Glu Glu Trp His  Ser Asp Asn Ser Asp  Gly Glu Ile 
    1160                 1165                 1170             


Ala Ser  Glu Cys Glu Cys Asp  Ser Val Phe Asn His  Leu Glu Glu 
    1175                 1180                 1185             


Leu Arg  Leu His Leu Glu Gln  Glu Met Gly Phe Glu  Lys Phe Phe 
    1190                 1195                 1200             


Glu Val  Tyr Glu Lys Ile Lys  Ala Ile His Glu Asp  Glu Asp Glu 
    1205                 1210                 1215             


Asn Ile  Glu Ile Cys Ser Lys  Ile Val Gln Asn Ile  Leu Gly Asn 
    1220                 1225                 1230             


Glu His  Gln His Leu Tyr Ala  Lys Ile Leu His Leu  Val Met Ala 
    1235                 1240                 1245             


Asp Gly  Ala Tyr Gln Glu Asp  Asn Asp Glu 
    1250                 1255             


<210>  4
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  morpholino

<400>  4
atgttagaaa gtgtacctcg atgca                                             25


<210>  5
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  morpholino

<400>  5
cctcttacct cagttacaat ttata                                             25


<210>  6
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  6
ctgccgtctc tctcctgagt c                                                 21


<210>  7
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  7
ttgtgcccag tcatagccga at                                                22


<210>  8
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  8
ttagacatgc tcccagccga tg                                                22


<210>  9
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  9
taccccgaag agtgagtttg cc                                                22


<210>  10
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  10
ctggtcgagc tggacggcga cg                                                22


<210>  11
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  11
cacgaactcc agcaggacca tg                                                22


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  12
ggataaatgt tggcgtgctt                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  13
tactctgcat gcctcaggtg                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  14
cccaggaggt ggagattgta                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  15
tagccaacca gttgacacca                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  16
tgtaatgtct gggcaaccaa                                                   20


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  17
tgggaaaaca atcttttgct g                                                 21


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  18
agcggggaca ctttaggatt                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  19
gggtgctgat aattggtgct                                                   20


<210>  20
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  20
accaggaaat gagcttgaca aa                                                22


<210>  21
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  21
tcaagaaggt ggtgaagcag g                                                 21


<210>  22
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  22
gatggatgct aaagccagac aggac                                             25


<210>  23
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  23
tcaatcttat ggcacagcga gagc                                              24


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  24
cccatgtttg tcatgggtgt                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  25
ggttgctgta accgaactca                                                   20


