                          SEQUENCE LISTING

<110>  ʦѧ
       ϺҫƼ޹˾
 
<120>  һ֦-鵰׹弰Ӧ

<130>  P22401201C

<150>  2021103040176
<151>  2021-03-22

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HS40

<400>  1
cgaccctctg gaacctatca gggaccacag tcagccaggc aagcacatct gcccaagcca       60

agggtggagg catgcagctg tgggggtctg tgaaaacact tgagggagca gataactggg      120

ccaaccatga ctcagtgctt ctggaggcca acaggactgc tgagtcatcc tgtgggggtg      180

gaggtgggac aagggaaagg ggtgaatggt actgctgatt acaacctctg gtgctgcctc      240

cccctcctgt ttatctgaga gggaaggcca tgcccaaagt gttcacagcc aggcttcagg      300

ggcaaagcct gacccagaca gtaaatacgt tcttcatctg gagctgaaga                 350


<210>  2
<211>  626
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  -鵰

<400>  2
ggtgcctgtc actcaagcac actagtgact atcgccagag ggaaagggag ctgcaggaag       60

cgaggctgga gagcaggagg ggctctgcgc agaaattctt ttgagttcct atgggccagg      120

gcgtccgggt gcgcgcattc ctctccgccc caggattggg cgaagccctc cggctcgcac      180

tcgctcgccc gtgtgttccc cgatcccgct ggagtcgatg cgcgtccagc gcgtgccagg      240

ccggggcggg ggtgcgggct gactttctcc ctcgctaggg acgctccggc gcccgaaagg      300

aaagggtggc gctgcgctcc ggggtgcacg agccgacagc gcccgacccc aacgggccgg      360

ccccgccagc gccgctaccg ccctgccccc gggcgagcgg gatgggcggg agtggagtgg      420

cgggtggagg gtggagacgt cctggccccc gccccgcgtg cacccccagg ggaggccgag      480

cccgccgccc ggccccgcgc aggccccgcc cgggactccc ctgcggtcca ggccgcgccc      540

cgggctccgc gccagccaat gagcgccgcc cggccgggcg tgcccccgcg ccccaagcat      600

aaaccctggc gcgctcgcgg gccggc                                           626


<210>  3
<211>  835
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HBA2

<400>  3
actcttctgg tccccacaga ctcagagaga acccaccatg gtgctgtctc ctgccgacaa       60

gaccaacgtc aaggccgcct ggggtaaggt cggcgcgcac gctggcgagt atggtgcgga      120

ggccctggag aggtgaggct ccctcccctg ctccgacccg ggctcctcgc ccgcccggac      180

ccacaggcca ccctcaaccg tcctggcccc ggacccaaac cccacccctc actctgcttc      240

tccccgcagg atgttcctgt ccttccccac caccaagacc tacttcccgc acttcgacct      300

gagccacggc tctgcccagg ttaagggcca cggcaagaag gtggccgacg cgctgaccaa      360

cgccgtggcg cacgtggacg acatgcccaa cgcgctgtcc gccctgagcg acctgcacgc      420

gcacaagctt cgggtggacc cggtcaactt caaggtgagc ggcgggccgg gagcgatctg      480

ggtcgagggg cgagatggcg ccttcctctc agggcagagg atcacgcggg ttgcgggagg      540

tgtagcgcag gcggcggctg cgggcctggg ccgcactgac cctcttctct gcacagctcc      600

taagccactg cctgctggtg accctggccg cccacctccc cgccgagttc acccctgcgg      660

tgcacgcctc cctggacaag ttcctggctt ctgtgagcac cgtgctgacc tccaaatacc      720

gttaagctgg agcctcggta gccgttcctc ctgcccgctg ggcctcccaa cgggccctcc      780

tcccctcctt gcaccggccc ttcctggtct ttgaataaag tctgagtggg cagca           835


<210>  4
<211>  477
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HBA23' sequence

<400>  4
gcctgtgtgt gcctgggttc tctctatccc ggaatgtgcc aacaatggag gtgtttacct       60

gtctcagacc aaggacctct ctgcagctgc atggggctgg ggagggagaa ctgcagggag      120

tatgggaggg gaagctgagg tgggcctgct caagagaagg tgctgaacca tcccctgtcc      180

tgagaggtgc caggcctgca ggcagtggct cagaagctgg ggaggagaga ggcatccagg      240

gttctactca gggagtccca gcatcgccac cctcctttga aatctccctg gttgaaccca      300

gttaacatac gctctccatc aaaacaaaac gaaacaaaac aaactagcaa aataggctgt      360

ccccagtgca agtgcaggtg ccagaacatt tctctcattc ccaccccttc ctgccagagg      420

gtaggtggct ggagtgaggg tgctggccct actcacactt cctgtgtcac ggtgacc         477


<210>  5
<211>  1157
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HS4

<400>  5
actagtgcat gcaaatctga cactcagtgg gcctgggtga aggtgagaat tttattgctg       60

aatgagagcc tctggggaca tcttgccagt caatgagtct caggttcaat ttccttctca      120

gtcttggagt aacagaagct catgcattta ataaacggaa attttgtatt gaaatgagag      180

ccattggaaa tcatttactc cagactccta cttataaaaa gagaaactga ggctcagaga      240

agggtgggga ctttctcagt atgacatgga aatgatcagg cttggattca aagctcctga      300

ctttctgtct agtgtatgtg cagtgagccc cttttcctct aactgaaaga aggaaaaaaa      360

aatggaaccc aaaatattct acatagtttc catgtcacag ccagggctgg gcagtctcct      420

gttatttctt ttaaaataaa tatatcattt aaatgcataa ataagcaaac cctgctcggg      480

aatgggaggg agagtctctg gagtccaccc cttctcggcc ctggctctgc agatagtgct      540

atcaaagccc tgacagagcc ctgcccattg ctgggccttg gagtgagtca gcctagtaga      600

gaggcagggc aagccatctc atagctgctg agtgggagag agaaaagggc tcattgtcta      660

taaactcagg tcatggctat tcttattctc acactaagaa aaagaatgag atgtctacat      720

ataccctgcg tcccctcttg tgtactgggg tccccaagag ctctctaaaa gtgatggcaa      780

agtcattgcg ctagatgcca tcccatctat tataaacctg catttgtctc cacacaccag      840

tcatggacaa taaccctcct cccaggtcca cgtgcttgtc tttgtataat actcaagtaa      900

tttcggaaaa tgtattcttt caatcttgtt ctgttattcc tgtttcaatg gcttagtaga      960

aaaagtacat acttgttttc ccataaattg acaatagaca atttcacatc aatgtctata     1020

tgggtcgttg tgtttgctgt gtttgcaaaa actcacaata actttatatt gttactactc     1080

taagaaagtt acaacatggt gaatacaaga gaaagctatt acaagtccag aaaataaaag     1140

ttatcatctt gaggcct                                                    1157


<210>  6
<211>  846
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HS3

<400>  6
ctggttagaa ggttctactg gaggagggtc ccagcccatt gctaaattaa catcaggctc       60

tgagactggc agtatatctc taacagtggt tgatgctatc ttctggaact tgcctgctac      120

attgagacca ctgacccata cataggaagc ccatagctct gtcctgaact gttaggccac      180

tggtccagag agtgtgcatc tcctttgatc ctcataataa ccctatgaga tagacacaat      240

tattactctt actttataga tgatgatcct gaaaacatag gagtcaaggc acttgcccct      300

agctgggggt ataggggagc agtcccatgt agtagtagaa tgaaaaatgc tgctatgctg      360

tgcctccccc acctttccca tgtctgccct ctactcatgg tctatctctc ctggctcctg      420

ggagtcatgg actccaccca gcaccaccaa cctgacctaa ccacctatct gagcctgcca      480

gcctataacc catctgggcc ctgatagctg gtggccagcc ctgaccccac cccaccctcc      540

ctggaacctc tgatagacac atctggcaca ccagctcgca aagtcaccgt gagggtcttg      600

tgtttgctga gtcaaaattc cttgaaatcc aagtccttag agactcctgc tcccaaattt      660

acagtcatag acttcttcat ggctgtctcc tttatccaca gaatgattcc tttgcttcat      720

tgccccatcc atctgatcct cctcatcagt gcagcacagg gcccatgagc agtagctgca      780

gagtctcaca taggtctggc actgcctctg acatgtccga ccttaggcaa atgcttgact      840

cttctg                                                                 846


<210>  7
<211>  693
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HS2

<400>  7
aggccttttg ccacctagct gtccaggggt gccttaaaat ggcaaacaag gtttgttttc       60

ttttcctgtt ttcatgcctt cctcttccat atccttgttt catattaata catgtgtata      120

gatcctaaaa atctatacac atgtattaat aaagcctgat tctgccgctt ctaggtatag      180

aggccacctg caagataaat atttgattca caataactaa tcattctatg gcaattgata      240

acaacaaata tatatatata tatatatata cgtatatgtg tatatatata tatatattca      300

ggaaataata tattctagaa tatgtcacat tctgtctcag gcatccattt tctttatgat      360

gccgtttgag gtggagtttt agtcaggtgg tcagcttctc cttttttttg ccatctgccc      420

tgtaagcatc ctgctgggga cccagatagg agtcatcact ctaggctgag aacatctggg      480

cacacaccct aagcctcagc atgactcatc atgactcagc attgctgtgc ttgagccaga      540

aggtttgctt agaaggttac acagaaccag aaggcggggg tggggcactg accccgacag      600

gggcctggcc agaactgctc atgcttggac tatgggaggt cactaatgga gacacacaga      660

aatgtaacag gaactaagga aaaactgaag ctt                                   693


<210>  8
<211>  265
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  -鵰

<400>  8
gtaaatacac ttgcaaagga ggatgttttt agtagcaatt tgtactgatg gtatggggcc       60

aagagatata tcttagaggg agggctgagg gtttgaagtc caactcctaa gccagtgcca      120

gaagagccaa ggacaggtac ggctgtcatc acttagacct caccctgtgg agccacaccc      180

tagggttggc caatctactc ccaggagcag ggagggcagg agccagggct gggcataaaa      240

gtcagggcag agccatctat tgctt                                            265


<210>  9
<211>  1090
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HBB3' sequence

<400>  9
tgatgtattt aaattatttc tgaatatttt actaaaaagg gaatgtggga ggtcagtgca       60

tttaaaacat aaagaaatga agagctagtt caaaccttgg gaaaatacac tatatcttaa      120

actccatgaa agaaggtgag gctgcaaaca gctaatgcac attggcaaca gcccctgatg      180

catatgcctt attcatccct cagaaaagga ttcaagtaga ggcttgattt ggaggttaaa      240

gttttgctat gctgtatttt acattactta ttgttttagc tgtcctcatg aatgtctttt      300

cactacccat ttgcttatcc tgcatctctc agccttgact ccactcagtt ctcttgctta      360

gagataccac ctttcccctg aagtgttcct tccatgtttt acggcgagat ggtttctcct      420

cgcctggcca ctcagcctta gttgtctctg ttgtcttata gaggtctact tgaagaagga      480

aaaacagggg tcatggtttg actgtcctgt gagcccttct tccctgcctc ccccactcac      540

agtgacccgg aatctgcagt gctagtctcc cggaactatc actctttcac agtctgcttt      600

ggaaggactg ggcttagtat gaaaagttag gactgagaag aatttgaaag gcggcttttt      660

gtagcttgat attcactact gtcttattac cctgtcatag gcccacccca aatggaagtc      720

ccattcttcc tcaggatgtt taagattagc attcaggaag agatcagagg tctgctggct      780

cccttatcat gtcccttatg gtgcttctgg ctctgcagtt attagcatag tgttaccatc      840

aaccacctta acttcatttt tcttattcaa tacctaggta ggtagatgct agattctgga      900

aataaaatat gagtctcaag tggtccttgt cctctctccc agtcaaattc tgaatctagt      960

tggcaagatt ctgaaatcaa ggcatataat cagtaataag tgatgataga agggtatata     1020

gaagaatttt attatatgag agggtgaaac cctcaaaatg aaatgaaatc agacccttgt     1080

cttacaccat                                                            1090


<210>  10
<211>  5910
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lenti

<400>  10
ctggaattcg agctcggtac ctttaagacc aatgacttac aaggcagctg tagatcttag       60

ccacttttta aaagaaaagg ggggactgga agggctaatt cactcccaac gaagacaaga      120

tctgcttttt gcttgtactg ggtctctctg gttagaccag atctgagcct gggagctctc      180

tggctaacta gggaacccac tgcttaagcc tcaataaagc ttgccttgag tgcttcaagt      240

agtgtgtgcc cgtctgttgt gtgactctgg taactagaga tccctcagac ccttttagtc      300

agtgtggaaa atctctagca gtagtagttc atgtcatctt attattcagt atttataact      360

tgcaaagaaa tgaatatcag agagtgagag gaacttgttt attgcagctt ataatggtta      420

caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag      480

ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggctctagc tatcccgccc      540

ctaactccgc ccatcccgcc cctaactccg cccagttccg cccattctcc gccccatggc      600

tgactaattt tttttattta tgcagaggcc gaggccgcct cggcctctga gctattccag      660

aagtagtgag gaggcttttt tggaggccta gggacgtacc caattcgccc tatagtgagt      720

cgtattacgc gcgctcactg gccgtcgttt tacaacgtcg tgactgggaa aaccctggcg      780

ttacccaact taatcgcctt gcagcacatc cccctttcgc cagctggcgt aatagcgaag      840

aggcccgcac cgatcgccct tcccaacagt tgcgcagcct gaatggcgaa tgggacgcgc      900

cctgtagcgg cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac      960

ttgccagcgc cctagcgccc gctcctttcg ctttcttccc ttcctttctc gccacgttcg     1020

ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt agggttccga tttagtgctt     1080

tacggcacct cgaccccaaa aaacttgatt agggtgatgg ttcacgtagt gggccatcgc     1140

cctgatagac ggtttttcgc cctttgacgt tggagtccac gttctttaat agtggactct     1200

tgttccaaac tggaacaaca ctcaacccta tctcggtcta ttcttttgat ttataaggga     1260

ttttgccgat ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga     1320

attttaacaa aatattaacg cttacaattt aggtggcact tttcggggaa atgtgcgcgg     1380

aacccctatt tgtttatttt tctaaataca ttcaaatatg tatccgctca tgagacaata     1440

accctgataa atgcttcaat aatattgaaa aaggaagagt atgagtattc aacatttccg     1500

tgtcgccctt attccctttt ttgcggcatt ttgccttcct gtttttgctc acccagaaac     1560

gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt acatcgaact     1620

ggatctcaac agcggtaaga tccttgagag ttttcgcccc gaagaacgtt ttccaatgat     1680

gagcactttt aaagttctgc tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga     1740

gcaactcggt cgccgcatac actattctca gaatgacttg gttgagtact caccagtcac     1800

agaaaagcat cttacggatg gcatgacagt aagagaatta tgcagtgctg ccataaccat     1860

gagtgataac actgcggcca acttacttct gacaacgatc ggaggaccga aggagctaac     1920

cgcttttttg cacaacatgg gggatcatgt aactcgcctt gatcgttggg aaccggagct     1980

gaatgaagcc ataccaaacg acgagcgtga caccacgatg cctgtagcaa tggcaacaac     2040

gttgcgcaaa ctattaactg gcgaactact tactctagct tcccggcaac aattaataga     2100

ctggatggag gcggataaag ttgcaggacc acttctgcgc tcggcccttc cggctggctg     2160

gtttattgct gataaatctg gagccggtga gcgtgggtct cgcggtatca ttgcagcact     2220

ggggccagat ggtaagccct cccgtatcgt agttatctac acgacgggga gtcaggcaac     2280

tatggatgaa cgaaatagac agatcgctga gataggtgcc tcactgatta agcattggta     2340

actgtcagac caagtttact catatatact ttagattgat ttaaaacttc atttttaatt     2400

taaaaggatc taggtgaaga tcctttttga taatctcatg accaaaatcc cttaacgtga     2460

gttttcgttc cactgagcgt cagaccccgt agaaaagatc aaaggatctt cttgagatcc     2520

tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt     2580

ttgtttgccg gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc     2640

gcagatacca aatactgttc ttctagtgta gccgtagtta ggccaccact tcaagaactc     2700

tgtagcaccg cctacatacc tcgctctgct aatcctgtta ccagtggctg ctgccagtgg     2760

cgataagtcg tgtcttaccg ggttggactc aagacgatag ttaccggata aggcgcagcg     2820

gtcgggctga acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga     2880

actgagatac ctacagcgtg agctatgaga aagcgccacg cttcccgaag ggagaaaggc     2940

ggacaggtat ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg     3000

gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg     3060

atttttgtga tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcggcctt     3120

tttacggttc ctggcctttt gctggccttt tgctcacatg ttctttcctg cgttatcccc     3180

tgattctgtg gataaccgta ttaccgcctt tgagtgagct gataccgctc gccgcagccg     3240

aacgaccgag cgcagcgagt cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc     3300

gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt ttcccgactg     3360

gaaagcgggc agtgagcgca acgcaattaa tgtgagttag ctcactcatt aggcacccca     3420

ggctttacac tttatgcttc cggctcgtat gttgtgtgga attgtgagcg gataacaatt     3480

tcacacagga aacagctatg accatgatta cgccaagcgc gcaattaacc ctcactaaag     3540

ggaacaaaag ctggagctgc aagcttaatg tagtcttatg caatactctt gtagtcttgc     3600

aacatggtaa cgatgagtta gcaacatgcc ttacaaggag agaaaaagca ccgtgcatgc     3660

cgattggtgg aagtaaggtg gtacgatcgt gccttattag gaaggcaaca gacgggtctg     3720

acatggattg gacgaaccac tgaattgccg cattgcagag atattgtatt taagtgccta     3780

gctcgataca taaacgggtc tctctggtta gaccagatct gagcctggga gctctctggc     3840

taactaggga acccactgct taagcctcaa taaagcttgc cttgagtgct tcaagtagtg     3900

tgtgcccgtc tgttgtgtga ctctggtaac tagagatccc tcagaccctt ttagtcagtg     3960

tggaaaatct ctagcagtgg cgcccgaaca gggacttgaa agcgaaaggg aaaccagagg     4020

agctctctcg acgcaggact cggcttgctg aagcgcgcac ggcaagaggc gaggggcggc     4080

gactggtgag tacgccaaaa attttgacta gcggaggcta gaaggagaga gatgggtgcg     4140

agagcgtcag tattaagcgg gggagaatta gatcgcgatg ggaaaaaatt cggttaaggc     4200

cagggggaaa gaaaaaatat aaattaaaac atatagtatg ggcaagcagg gagctagaac     4260

gattcgcagt taatcctggc ctgttagaaa catcagaagg ctgtagacaa atactgggac     4320

agctacaacc atcccttcag acaggatcag aagaacttag atcattatat aatacagtag     4380

caaccctcta ttgtgtgcat caaaggatag agataaaaga caccaaggaa gctttagaca     4440

agatagagga agagcaaaac aaaagtaaga ccaccgcaca gcaagcggcc gctgatcttc     4500

agacctggag gaggagatat gagggacaat tggagaagtg aattatataa atataaagta     4560

gtaaaaattg aaccattagg agtagcaccc accaaggcaa agagaagagt ggtgcagaga     4620

gaaaaaagag cagtgggaat aggagctttg ttccttgggt tcttgggagc agcaggaagc     4680

actatgggcg cagcgtcaat gacgctgacg gtacaggcca gacaattatt gtctggtata     4740

gtgcagcagc agaacaattt gctgagggct attgaggcgc aacagcatct gttgcaactc     4800

acagtctggg gcatcaagca gctccaggca agaatcctgg ctgtggaaag atacctaaag     4860

gatcaacagc tcctggggat ttggggttgc tctggaaaac tcatttgcac cactgctgtg     4920

ccttggaatg ctagttggag taataaatct ctggaacaga tttggaatca cacgacctgg     4980

atggagtggg acagagaaat taacaattac acaagcttaa tacactcctt aattgaagaa     5040

tcgcaaaacc agcaagaaaa gaatgaacaa gaattattgg aattagataa atgggcaagt     5100

ttgtggaatt ggtttaacat aacaaattgg ctgtggtata taaaattatt cataatgata     5160

gtaggaggct tggtaggttt aagaatagtt tttgctgtac tttctatagt gaatagagtt     5220

aggcagggat attcaccatt atcgtttcag acccacctcc caaccccgag gggacccgac     5280

aggcccgaag gaatagaaga agaaggtgga gagagagaca gagacagatc cattcgatta     5340

gtgaacggat ctcgacggta tcgattagac tgtagcccag gaatatggca gctagattgt     5400

acacatttag aaggaaaagt tatcttggta gcagttcatg tagccagtgg atatatagaa     5460

gcagaagtaa ttccagcaga gacagggcaa gaaacagcat acttcctctt aaaattagca     5520

ggaagatggc cagtaaaaac agtacataca gacaatggca gcaatttcac cagtactaca     5580

gttaaggccg cctgttggtg ggcggggatc aagcaggaat ttggcattcc ctacaatccc     5640

caaagtcaag gagtaataga atctatgaat aaagaattaa agaaaattat aggacaggta     5700

agagatcagg ctgaacatct taagacagca gtacaaatgg cagtattcat ccacaatttt     5760

aaaagaaaag gggggattgg ggggtacagt gcaggggaaa gaatagtaga cataatagca     5820

acagacatac aaactaaaga attacaaaaa caaattacaa aaattcaaaa ttttcgggtt     5880

tattacaggg acagcagaga tccagtttgg                                      5910


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SgRNA

<400>  11
gatggagagc gtatgttaac                                                   20


