                         б

<110>  ǻƼɷ޹˾

<120>  CHI3L1弰Ӧáᡢϵͳϸ

<140>  SP21718145WO

<160>  24

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  16
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<223>  VLCDR1

<400>  1

Arg Ser Ser Gln Thr Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  2
<211>  7
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<223>  VLCDR2

<400>  2

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<223>  VLCDR3

<400>  3

Phe Gln Gly Ser His Val Pro Pro Thr 
1               5                   


<210>  4
<211>  5
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<223>  VHCDR1

<400>  4

Ser Tyr Trp Ile Glu 
1               5   


<210>  5
<211>  17
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<223>  VHCDR2

<400>  5

Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn Cys Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    

<210>  6
<211>  7
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<223>  VHCDR3

<400>  6

Ser Asp Asp Tyr Tyr Asp Tyr 
1               5           


<210>  7
<211>  131
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<223>  VL

<400>  7

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile 
        35                  40                  45              


Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            100                 105                 110         


Phe Gln Gly Ser His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  8
<211>  135
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<223>  VH

<400>  8

Met Asp Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Arg Thr Thr Gly Tyr Thr Phe 
        35                  40                  45              


Ser Ser Tyr Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn Cys Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Val Arg Ser Asp Asp Tyr Tyr Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Leu Thr Val Ser Ser 
    130                 135 


<210>  9
<211>  393
<212>  DNA
<213>  ˹(Artificial Sequence)

<220>
<223>  VLĺ

<400>  9

atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat        60

gttttgatga cccaaactcc actctccctg cctgtcagtc ttggagatca agcctccatc       120

tcttgcagat ctagtcagac cattgtacat agtaatggaa acacctattt agaatggtac       180

ctgcagaaac caggccagtc tccaaaactc ctgatctaca aagtttccaa ccgattttct       240

ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc       300

agagtggagg ctgaggatct gggagtttat tactgctttc aaggttcaca tgttcctccg       360

acgttcggtg gaggcaccaa gctggaaatc aaa                                    393


<210>  10
<211>  405
<212>  DNA
<213>  ˹(Artificial Sequence)

<220>
<223>  VHĺ

<400>  10

atggattgga cctgggtctt tctcttcctc ctgtcagtaa ctgcaggtgt ccactcccag        60

gttcagctgc agcagtctgg agctgagctg atgaagcctg gggcctcagt gaagatatcc       120

tgcaggacta ctggctacac attcagtagc tactggatag agtgggtgaa gcagaggcct       180

ggacatggcc ttgagtggat tggagagatt ttacctggaa gtggtagtac taactgcaat       240

gagaagttca agggcaaggc cacattcact gcagatacat cctccaacac agcctacatg       300

caactcagca gcctgacatc tgaggactct gccgtctatt actgtgtaag atcggatgat       360

tactacgact actggggcca aggcaccact ctcacagtct cctca                       405


<210>  11
<211>  106
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<223>  CL

<400>  11

Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
1               5                   10                  15      


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
        35                  40                  45              


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
65                  70                  75                  80  


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
                85                  90                  95      


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
            100                 105     


<210>  12
<211>  324
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<223>  CH

<400>  12

Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala 
1               5                   10                  15      


Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
    50                  55                  60                  


Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val 
65                  70                  75                  80  


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                  90                  95      


Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro 
            100                 105                 110         


Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
        115                 120                 125             


Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser 
    130                 135                 140                 


Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu 
145                 150                 155                 160 


Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr 
                165                 170                 175     


Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn 
            180                 185                 190         


Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro 
        195                 200                 205             


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln 
    210                 215                 220                 


Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val 
225                 230                 235                 240 


Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val 
                245                 250                 255     


Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln 
            260                 265                 270         


Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn 
        275                 280                 285             


Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val 
    290                 295                 300                 


Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His 
305                 310                 315                 320 


Ser Pro Gly Lys 
                


<210>  13
<211>  23
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<223>  FR1

<400>  13

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys 
            20              


<210>  14
<211>  15
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<223>  FR2

<400>  14

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  15
<211>  32
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<223>  FR3

<400>  15

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            20                  25                  30          

<210>  16
<211>  10
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<223>  FR4

<400>  16

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  17
<211>  30
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<223>  FR1

<400>  17

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Arg Thr Thr Gly Tyr Thr Phe Ser 
            20                  25                  30  


<210>  18
<211>  14
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<223>  FR2

<400>  18

Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  19
<211>  32
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<223>  FR3

<400>  19

Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr Met Gln 
1               5                   10                  15      

Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Val Arg 
            20                  25                  30          


<210>  20
<211>  11
<212>  PRT
<213>  ˹(Artificial Sequence)

<220>
<223>  FR4

<400>  20

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10      


<210>  21
<211>  25
<212>  DNA
<213>  ˹(Artificial Sequence)

<220>
<223>  1

<400>  21

tggratgsag ctgkgtmats ctctt                                              25


<210>  22
<211>  26
<212>  DNA
<213>  ˹(Artificial Sequence)

<220>
<223>  2

<400>  22

tgtygtgcta gctgnrgaga cdgtga                                             26


<210>  23
<211>  21
<212>  DNA
<213>  ˹(Artificial Sequence)

<220>
<223>  3

<400>  23

atggagacac actcctgcta t                                                  21


<210>  24
<211>  26
<212>  DNA
<213>  ˹(Artificial Sequence)

<220>
<223>  4

<400>  24

gtcgacttac gtttkatttc carctt                                             26

