                         SEQUENCE LISTING

<110>  Ohio State Innovation Foundation
 
<120>  EXTRACELLULAR VESICLE-BASED NANOCARRIERS

<130>  321501-2540

<150>  US 63/161,093
<151>  2021-03-15

<160>  58    

<170>  PatentIn version 3.5

<210>  1
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2

<400>  1

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  2
<211>  3819
<212>  DNA
<213>  Severe acute respiratory syndrome coronavirus 2

<400>  2
atgtttgttt ttcttgtttt attgccacta gtctctagtc agtgtgttaa tcttacaacc       60

agaactcaat taccccctgc atacactaat tctttcacac gtggtgttta ttaccctgac      120

aaagttttca gatcctcagt tttacattca actcaggact tgttcttacc tttcttttcc      180

aatgttactt ggttccatgc tatacatgtc tctgggacca atggtactaa gaggtttgat      240

aaccctgtcc taccatttaa tgatggtgtt tattttgctt ccactgagaa gtctaacata      300

ataagaggct ggatttttgg tactacttta gattcgaaga cccagtccct acttattgtt      360

aataacgcta ctaatgttgt tattaaagtc tgtgaatttc aattttgtaa tgatccattt      420

ttgggtgttt attaccacaa aaacaacaaa agttggatgg aaagtgagtt cagagtttat      480

tctagtgcga ataattgcac ttttgaatat gtctctcagc cttttcttat ggaccttgaa      540

ggaaaacagg gtaatttcaa aaatcttagg gaatttgtgt ttaagaatat tgatggttat      600

tttaaaatat attctaagca cacgcctatt aatttagtgc gtgatctccc tcagggtttt      660

tcggctttag aaccattggt agatttgcca ataggtatta acatcactag gtttcaaact      720

ttacttgctt tacatagaag ttatttgact cctggtgatt cttcttcagg ttggacagct      780

ggtgctgcag cttattatgt gggttatctt caacctagga cttttctatt aaaatataat      840

gaaaatggaa ccattacaga tgctgtagac tgtgcacttg accctctctc agaaacaaag      900

tgtacgttga aatccttcac tgtagaaaaa ggaatctatc aaacttctaa ctttagagtc      960

caaccaacag aatctattgt tagatttcct aatattacaa acttgtgccc ttttggtgaa     1020

gtttttaacg ccaccagatt tgcatctgtt tatgcttgga acaggaagag aatcagcaac     1080

tgtgttgctg attattctgt cctatataat tccgcatcat tttccacttt taagtgttat     1140

ggagtgtctc ctactaaatt aaatgatctc tgctttacta atgtctatgc agattcattt     1200

gtaattagag gtgatgaagt cagacaaatc gctccagggc aaactggaaa gattgctgat     1260

tataattata aattaccaga tgattttaca ggctgcgtta tagcttggaa ttctaacaat     1320

cttgattcta aggttggtgg taattataat tacctgtata gattgtttag gaagtctaat     1380

ctcaaacctt ttgagagaga tatttcaact gaaatctatc aggccggtag cacaccttgt     1440

aatggtgttg aaggttttaa ttgttacttt cctttacaat catatggttt ccaacccact     1500

aatggtgttg gttaccaacc atacagagta gtagtacttt cttttgaact tctacatgca     1560

ccagcaactg tttgtggacc taaaaagtct actaatttgg ttaaaaacaa atgtgtcaat     1620

ttcaacttca atggtttaac aggcacaggt gttcttactg agtctaacaa aaagtttctg     1680

cctttccaac aatttggcag agacattgct gacactactg atgctgtccg tgatccacag     1740

acacttgaga ttcttgacat tacaccatgt tcttttggtg gtgtcagtgt tataacacca     1800

ggaacaaata cttctaacca ggttgctgtt ctttatcagg atgttaactg cacagaagtc     1860

cctgttgcta ttcatgcaga tcaacttact cctacttggc gtgtttattc tacaggttct     1920

aatgtttttc aaacacgtgc aggctgttta ataggggctg aacatgtcaa caactcatat     1980

gagtgtgaca tacccattgg tgcaggtata tgcgctagtt atcagactca gactaattct     2040

cctcggcggg cacgtagtgt agctagtcaa tccatcattg cctacactat gtcacttggt     2100

gcagaaaatt cagttgctta ctctaataac tctattgcca tacccacaaa ttttactatt     2160

agtgttacca cagaaattct accagtgtct atgaccaaga catcagtaga ttgtacaatg     2220

tacatttgtg gtgattcaac tgaatgcagc aatcttttgt tgcaatatgg cagtttttgt     2280

acacaattaa accgtgcttt aactggaata gctgttgaac aagacaaaaa cacccaagaa     2340

gtttttgcac aagtcaaaca aatttacaaa acaccaccaa ttaaagattt tggtggtttt     2400

aatttttcac aaatattacc agatccatca aaaccaagca agaggtcatt tattgaagat     2460

ctacttttca acaaagtgac acttgcagat gctggcttca tcaaacaata tggtgattgc     2520

cttggtgata ttgctgctag agacctcatt tgtgcacaaa agtttaacgg ccttactgtt     2580

ttgccacctt tgctcacaga tgaaatgatt gctcaataca cttctgcact gttagcgggt     2640

acaatcactt ctggttggac ctttggtgca ggtgctgcat tacaaatacc atttgctatg     2700

caaatggctt ataggtttaa tggtattgga gttacacaga atgttctcta tgagaaccaa     2760

aaattgattg ccaaccaatt taatagtgct attggcaaaa ttcaagactc actttcttcc     2820

acagcaagtg cacttggaaa acttcaagat gtggtcaacc aaaatgcaca agctttaaac     2880

acgcttgtta aacaacttag ctccaatttt ggtgcaattt caagtgtttt aaatgatatc     2940

ctttcacgtc ttgacaaagt tgaggctgaa gtgcaaattg ataggttgat cacaggcaga     3000

cttcaaagtt tgcagacata tgtgactcaa caattaatta gagctgcaga aatcagagct     3060

tctgctaatc ttgctgctac taaaatgtca gagtgtgtac ttggacaatc aaaaagagtt     3120

gatttttgtg gaaagggcta tcatcttatg tccttccctc agtcagcacc tcatggtgta     3180

gtcttcttgc atgtgactta tgtccctgca caagaaaaga acttcacaac tgctcctgcc     3240

atttgtcatg atggaaaagc acactttcct cgtgaaggtg tctttgtttc aaatggcaca     3300

cactggtttg taacacaaag gaatttttat gaaccacaaa tcattactac agacaacaca     3360

tttgtgtctg gtaactgtga tgttgtaata ggaattgtca acaacacagt ttatgatcct     3420

ttgcaacctg aattagactc attcaaggag gagttagata aatattttaa gaatcataca     3480

tcaccagatg ttgatttagg tgacatctct ggcattaatg cttcagttgt aaacattcaa     3540

aaagaaattg accgcctcaa tgaggttgcc aagaatttaa atgaatctct catcgatctc     3600

caagaacttg gaaagtatga gcagtatata aaatggccat ggtacatttg gctaggtttt     3660

atagctggct tgattgccat agtaatggtg acaattatgc tttgctgtat gaccagttgc     3720

tgtagttgtc tcaagggctg ttgttcttgt ggatcctgct gcaaatttga tgaagacgac     3780

tctgagccag tgctcaaagg agtcaaatta cattacacc                            3819


<210>  3
<211>  957
<212>  PRT
<213>  Homo sapiens

<400>  3

Glu Leu Leu Cys Tyr Ser Glu Leu Gln Pro Gln Pro Arg Tyr Gly Ser 
1               5                   10                  15      


Gln Gln Pro Pro Ala Arg Ala Ala Arg Thr Pro Gly Pro Ala Arg Gly 
            20                  25                  30          


Ser Val Pro Arg Thr Trp Gln Cys Pro Asp Ile Cys Val Pro Leu Lys 
        35                  40                  45              


Ser His Pro Ala Pro Gly Arg Leu Arg Ala Gly Asp Met Gln His Leu 
    50                  55                  60                  


Leu Pro Ala Gln Val Val Gly His Arg Asp Pro Val Ala Lys Gly Val 
65                  70                  75                  80  


Ala Pro Ala Trp Glu Gln Pro Glu Gly Val Thr Glu Gln Cys Ala Arg 
                85                  90                  95      


Arg Pro Thr Asn Val Leu Phe Lys Leu Pro Trp Ala Val Asn Ser Asn 
            100                 105                 110         


Leu Pro His Arg Val Leu Asp Ser Arg Thr Gly Gly Thr Gly Thr Pro 
        115                 120                 125             


Pro Leu Leu Ala Ala Ser Gly Gln Glu Pro Tyr Pro Thr Leu Pro Gly 
    130                 135                 140                 


Gly Gly Trp Gly Thr Pro Gly Gln Pro His Arg Gly Ala Ala Pro Trp 
145                 150                 155                 160 


Gly Glu Gly Ala Glu Thr Gly Ala Ser Cys Gly Gly Ala Arg Gly His 
                165                 170                 175     


Asp His Gly Ala Gly Glu Glu Arg Ser Pro Trp Ser Gln Phe Leu Val 
            180                 185                 190         


Pro His Thr Gly Pro Ala Ala Pro Arg Ala Gly Ala Val Glu His Leu 
        195                 200                 205             


Gly Pro Leu Pro Ala Pro Asp Leu Cys Pro Ala Ser Asp Ser Pro Thr 
    210                 215                 220                 


Thr Cys Gln Pro Pro Gly Pro Arg Gly Gly His Ala Gly Asp Arg Gly 
225                 230                 235                 240 


Leu Phe Pro Gly Arg Ala Val Pro Ser Leu Gly Gly Pro Gly Pro Pro 
                245                 250                 255     


Gly Thr Gly Gly Pro Glu Val Glu Pro His Ser His Leu Trp Gln Arg 
            260                 265                 270         


Leu Leu Leu Gly Gln Gly Leu Ser Gln Cys Asp Arg Arg Gly Arg Gly 
        275                 280                 285             


His Pro Ala Ala Asp Val Cys Ser Asn Thr Gly Glu Pro Glu Pro Gly 
    290                 295                 300                 


Asp Thr Ala Asp Ser Asp His Leu Gln Leu Ser Gly Ala Gln Arg Asp 
305                 310                 315                 320 


Ser Asp Glu Ala Arg Gly Leu Arg Arg Asp Arg Gly Asp Ser Glu Val 
                325                 330                 335     


Gly Pro Pro Ser Gln Gly Asp Ala Glu Trp Gly Ser Ser Pro Ala Thr 
            340                 345                 350         


Gly Pro Glu Gly Pro Ala Pro Ala Glu Gly His Pro Arg Gly Gln Arg 
        355                 360                 365             


Ala Gln Leu Leu Leu Leu Cys Asn Pro Gly Gly Gly Arg Pro Ala Tyr 
    370                 375                 380                 


Thr Gln Glu Pro Asp Pro Gly Ala Ser Cys Pro Val Trp Pro Pro Thr 
385                 390                 395                 400 


Gly Arg Glu Gly Leu Ser Gly Lys Leu Asp Val Ala Arg Lys Phe Pro 
                405                 410                 415     


Ala Asp Ser Asn Val Pro Gly Leu Gly Glu Pro Ile Ala Arg Ala Gln 
            420                 425                 430         


Val Ser Lys Gly Trp His Phe Pro Thr Ala His Arg Gly Ile Ser Asp 
        435                 440                 445             


Cys His Ser Arg Ser Gly His Leu Pro Leu Ser Gly Gln Glu His Ser 
    450                 455                 460                 


Arg Gly Gly His Pro Gln Gly Asp Arg Glu Cys Ala Leu Pro Pro Val 
465                 470                 475                 480 


Asp Cys His His His Cys Gly Ser Ser Arg Ser His Asn Gly His Cys 
                485                 490                 495     


Arg Pro Gln His Val Pro Leu Pro Pro Ala Glu Asp Gln Glu Ile Gln 
            500                 505                 510         


Thr Thr Thr Gly Pro Lys Arg Asp Pro His Glu Thr Glu His Thr Ser 
        515                 520                 525             


His Ala Ser Leu Asn Leu Ser Arg Asp Arg Ala Ser Ser Ser Ala Phe 
    530                 535                 540                 


Pro Tyr Trp Trp Gln Trp Cys His Thr Glu Gln Ser Gly Arg His Met 
545                 550                 555                 560 


Pro Cys Ser Tyr Thr Tyr Arg Pro Trp Asp Ala Gly Gly Gln Gly Ile 
                565                 570                 575     


Val Leu Ser Gln Ile Gln Gln His Leu Gly Pro Trp Tyr Leu His Thr 
            580                 585                 590         


Asn Thr Arg Pro Arg Ile Ser Val Val Thr Leu Ser Gln Glu Glu Gly 
        595                 600                 605             


Ala Arg Leu Lys Thr Leu Met Asp Val Lys Val Pro Asp Glu Arg Gly 
    610                 615                 620                 


Ser Gly Gly Gly Asp Ile Ala Pro Pro Gly His Thr Thr Gly Lys Tyr 
625                 630                 635                 640 


Asn Leu Leu Pro Ile Gly Tyr Ala Glu Ala Pro Gln Thr Tyr Arg Arg 
                645                 650                 655     


Ser Gly Pro Pro Thr Cys Val Ala Ser Lys His Lys Gly Pro His Phe 
            660                 665                 670         


Leu Thr Asp Ala Ser Leu Gly Thr Ala Val Tyr Pro Gln Pro Leu Met 
        675                 680                 685             


Ile Cys Ile Tyr Ser Phe Val Ile Leu Pro Ala Ile Tyr Val Ser Phe 
    690                 695                 700                 


Met Ala Lys Thr Val Ser Gly Leu Thr Glu Leu Pro Val Leu Ile Thr 
705                 710                 715                 720 


Phe Lys Val Thr Arg Tyr Ser Cys Thr Gly Cys Thr Leu Gln Glu Ser 
                725                 730                 735     


Ala Trp Gln Lys Asp Gln Met Gly Leu Gly Leu Leu Ile Gly Gln Pro 
            740                 745                 750         


Ala Phe Pro Gln Lys Glu Phe Phe Tyr Arg His Lys Ser Thr Ile Trp 
        755                 760                 765             


Thr Gly Asn Gly Tyr Arg Phe Arg Asp Tyr Pro Val Arg Pro Tyr Ser 
    770                 775                 780                 


Ser Leu Pro Pro Lys Thr Asp Thr Phe Val Ser His Leu Pro Thr His 
785                 790                 795                 800 


Ile His Phe Cys Gln Cys Ser Gln His Ser Ala Val Met Ser Gly His 
                805                 810                 815     


Glu Cys Pro Gly Asn Met Pro Lys Leu Cys Leu Val Leu Leu Ser Cys 
            820                 825                 830         


Leu His Phe Thr Gly Ser Leu His Tyr Ala Ala Pro Val Ser Cys Ser 
        835                 840                 845             


Asp Gln Gly Pro Ala Ser Ser Gly Glu Gly Gly Gln Gly Ile Gly Gly 
    850                 855                 860                 


Leu Pro Pro Ser Phe Gly Ser Leu Ile Arg Val Cys Val Cys Val Tyr 
865                 870                 875                 880 


Val Thr Ser Ser Arg Ser Val Thr Gln Ala Gly Val Gln Trp Cys Asn 
                885                 890                 895     


His Gly Ser Leu Gln Ser Pro Phe Gly Leu Lys Ser Ser His Leu Ser 
            900                 905                 910         


Leu Leu Ser Ser Trp Asp His Arg Leu Thr Thr Pro His Leu Ala Asn 
        915                 920                 925             


Leu Ile Phe Phe Phe Phe Pro Glu Thr Gly Ser Arg Asn Ile Ala Gln 
    930                 935                 940                 


Thr Ser Phe Val Leu Val Asn Lys Ala Phe Ser Thr Ala 
945                 950                 955         


<210>  4
<211>  2967
<212>  DNA
<213>  Homo sapiens

<400>  4
gagctcctct gctactcaga gttgcaacct cagcctcgct atggctccca gcagcccccg       60

gcccgcgctg cccgcactcc tggtcctgct cggggctctg ttcccaggac ctggcaatgc      120

ccagacatct gtgtccccct caaaagtcat cctgccccgg ggaggctccg tgctggtgac      180

atgcagcacc tcctgtgacc agcccaagtt gttgggcata gagaccccgt tgcctaaaaa      240

ggagttgctc ctgcctggga acaaccggaa ggtgtatgaa ctgagcaatg tgcaagaaga      300

tagccaacca atgtgctatt caaactgccc tgatgggcag tcaacagcta aaaccttcct      360

caccgtgtac tggactccag aacgggtgga actggcaccc ctcccctctt ggcagccagt      420

gggcaagaac cttaccctac gctgccaggt ggagggtggg gcaccccggg ccaacctcac      480

cgtggtgctg ctccgtgggg agaaggagct gaaacgggag ccagctgtgg gggagcccgc      540

tgaggtcacg accacggtgc tggtgaggag agatcaccat ggagccaatt tctcgtgccg      600

cactgaactg gacctgcggc cccaagggct ggagctgttt gagaacacct cggcccccta      660

ccagctccag acctttgtcc tgccagcgac tcccccacaa cttgtcagcc cccgggtcct      720

agaggtggac acgcagggga ccgtggtctg ttccctggac gggctgttcc cagtctcgga      780

ggcccaggtc cacctggcac tgggggacca gaggttgaac cccacagtca cctatggcaa      840

cgactccttc tcggccaagg cctcagtcag tgtgaccgca gaggacgagg gcacccagcg      900

gctgacgtgt gcagtaatac tggggaacca gagccaggag acactgcaga cagtgaccat      960

ctacagcttt ccggcgccca acgtgattct gacgaagcca gaggtctcag aagggaccga     1020

ggtgacagtg aagtgtgagg cccaccctag agccaaggtg acgctgaatg gggttccagc     1080

ccagccactg ggcccgaggg cccagctcct gctgaaggcc accccagagg acaacgggcg     1140

cagcttctcc tgctctgcaa ccctggaggt ggccggccag cttatacaca agaaccagac     1200

ccgggagctt cgtgtcctgt atggcccccg actggacgag agggattgtc cgggaaactg     1260

gacgtggcca gaaaattccc agcagactcc aatgtgccag gcttggggga acccattgcc     1320

cgagctcaag tgtctaaagg atggcacttt cccactgccc atcggggaat cagtgactgt     1380

cactcgagat cttgagggca cctacctctg tcgggccagg agcactcaag gggaggtcac     1440

ccgcaaggtg accgtgaatg tgctctcccc ccggtatgag attgtcatca tcactgtggt     1500

agcagccgca gtcataatgg gcactgcagg cctcagcacg tacctctata accgccagcg     1560

gaagatcaag aaatacagac tacaacaggc ccaaaaaggg acccccatga aaccgaacac     1620

acaagccacg cctccctgaa cctatcccgg gacagggcct cttcctcggc cttcccatat     1680

tggtggcagt ggtgccacac tgaacagagt ggaagacata tgccatgcag ctacacctac     1740

cggccctggg acgccggagg acagggcatt gtcctcagtc agatacaaca gcatttgggg     1800

ccatggtacc tgcacaccta aaacactagg ccacgcatct gatctgtagt cacatgacta     1860

agccaagagg aaggagcaag actcaagaca tgattgatgg atgttaaagt ctagcctgat     1920

gagaggggaa gtggtggggg agacatagcc ccaccatgag gacatacaac tgggaaatac     1980

tgaaacttgc tgcctattgg gtatgctgag gccccacaga cttacagaag aagtggccct     2040

ccatagacat gtgtagcatc aaaacacaaa ggcccacact tcctgacgga tgccagcttg     2100

ggcactgctg tctactgacc ccaacccttg atgatatgta tttattcatt tgttatttta     2160

ccagctattt attgagtgtc ttttatgtag gctaaatgaa cataggtctc tggcctcacg     2220

gagctcccag tcctaatcac attcaaggtc accaggtaca gttgtacagg ttgtacactg     2280

caggagagtg cctggcaaaa agatcaaatg gggctgggac ttctcattgg ccaacctgcc     2340

tttccccaga aggagtgatt tttctatcgg cacaaaagca ctatatggac tggtaatggt     2400

tacaggttca gagattaccc agtgaggcct tattcctccc ttccccccaa aactgacacc     2460

tttgttagcc acctccccac ccacatacat ttctgccagt gttcacaatg acactcagcg     2520

gtcatgtctg gacatgagtg cccagggaat atgcccaagc tatgccttgt cctcttgtcc     2580

tgtttgcatt tcactgggag cttgcactat gcagctccag tttcctgcag tgatcagggt     2640

cctgcaagca gtggggaagg gggccaaggt attggaggac tccctcccag ctttggaagc     2700

ctcatccgcg tgtgtgtgtg tgtgtatgtg tagacaagct ctcgctctgt cacccaggct     2760

ggagtgcagt ggtgcaatca tggttcactg cagtcttgac cttttgggct caagtgatcc     2820

tcccacctca gcctcctgag tagctgggac cataggctca caacaccaca cctggcaaat     2880

ttgatttttt ttttttttcc agagacgggg tctcgcaaca ttgcccagac ttcctttgtg     2940

ttagttaata aagctttctc aactgcc                                         2967


<210>  5
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  5

Ile Ser Arg Ala Gly Pro Gly Ser Leu Ala Arg Gly Pro Leu Val Arg 
1               5                   10                  15      


Ala Phe Cys His Gly Val Ser Val Pro Ser Val Ala Ala Val Phe Phe 
            20                  25                  30          


Gly Gly Arg Leu Pro Gly Ser Trp Glu Arg Ala Gly Thr Pro Asp Ala 
        35                  40                  45              


Gly Ala Lys Pro Gln Gly Pro Ser Arg Ala Leu Arg Asp Leu Ser Ala 
    50                  55                  60                  


Leu Leu Gly Ala His Glu Pro Gly Val Arg Gly Cys Ala Ala Gly Glu 
65                  70                  75                  80  


Val Ser Ala Ala Gln Leu Gln Gln Gln Leu Ser Pro Ala Ala Glu Phe 
                85                  90                  95      


Gln Pro Pro His Pro Ala Ala Ala Arg Gln Asp Ala Gln Arg Ala Gly 
            100                 105                 110         


Leu Gly Val Leu Pro Ala Ala Arg Arg Glu Gly Leu Glu Leu Pro Arg 
        115                 120                 125             


Ala Leu Pro Arg Asp Leu Arg Arg Lys Asn Thr Leu Gly His Leu Gln 
    130                 135                 140                 


Asp His Arg Leu Gln Cys Ser Arg Trp Ala Thr Trp Trp Pro Gly Met 
145                 150                 155                 160 


Glu Ala Gly Ser Ser Ile Pro Lys Ala Trp Ser Ala Ser Pro Ala Trp 
                165                 170                 175     


Ile Trp Pro Thr Pro Pro Thr Ser Leu Leu Leu Asp Pro Ala Thr Ser 
            180                 185                 190         


Gly Ser Pro Ser Ala Thr Arg Ala Ser Ile Ser Thr Ala Trp Trp Ser 
        195                 200                 205             


Ala Thr Ala Arg His Pro Leu His Cys Ser Leu Gly Ala Pro Arg Pro 
    210                 215                 220                 


Gln Leu Trp Pro Pro Val Pro Ser Leu Pro Leu Gly Ser Ser Ser Leu 
225                 230                 235                 240 


Trp Ala Leu Arg Thr Tyr Ala Ser Ala Leu Ser Pro Arg Arg Lys Gly 
                245                 250                 255     


Gly Cys Ser Met Pro Ala Glu Arg Glu Lys Glu Glu Tyr Glu Thr Ile 
            260                 265                 270         


Trp Gly Asn Gly His Thr Trp Trp Leu Thr Pro Val Ile Pro Ala Leu 
        275                 280                 285             


Trp Glu Ala Glu Ala Gly Glu Ser Leu Glu Pro Arg Ser Ser Arg Pro 
    290                 295                 300                 


Ala Trp Thr Thr Asp Pro Val Tyr Ala Lys Asn Thr Gln Ile Ser Leu 
305                 310                 315                 320 


Val Trp Trp Pro Ala Pro Val Val Pro Ala Thr Arg Glu Ala Glu Leu 
                325                 330                 335     


Gly Gly Ser Phe Glu Pro Lys Ser Arg Leu Gln Ala Leu Ile Val Pro 
            340                 345                 350         


Leu His Ser Ser Leu Gly Asp Arg Ala Arg Pro Cys Leu Gln Lys Asn 
        355                 360                 365             


Lys Asn Lys Asn Lys Tyr Trp Arg Gly Asn Pro Leu Glu Ser Ile Lys 
    370                 375                 380                 


Ala Ser Leu Thr 
385             


<210>  6
<211>  1213
<212>  DNA
<213>  Homo sapiens

<400>  6
atctctagag ccggccctgg ctctctggcg cggggcccct tagtccgggc tttttgccat       60

ggggtctctg ttccctctgt cgctgctgtt ttttttggcg gccgcctacc cgggagttgg      120

gagcgcgctg ggacgccgga ctaagcgggc gcaaagcccc aagggtagcc ctctcgcgcc      180

ctccgggacc tcagtgccct tctgggtgcg catgagcccg gagttcgtgg ctgtgcagcc      240

ggggaagtca gtgcagctca attgcagcaa cagctgtccc cagccgcaga attccagcct      300

ccgcaccccg ctgcggcaag gcaagacgct cagagggccg ggttgggtgt cttaccagct      360

gctcgacgtg agggcctgga gctccctcgc gcactgcctc gtgacctgcg caggaaaaac      420

acgctgggcc acctccagga tcaccgccta cagtgttccc ggtgggctac ttggtggtga      480

ccctgaggca tggaagccgg gtcatctatt ccgaaagcct ggagcgcttc accggcctgg      540

atctggccaa cgtgaccttg acctacgagt ttgctgctgg accccgcgac ttctggcagc      600

ccgtgatctg ccacgcgcgc ctcaatctcg acggcctggt ggtccgcaac agctcggcac      660

ccattacact gatgctcgct tggagccccg cgcccacagc tttggcctcc ggttccatcg      720

ctgcccttgt agggatcctc ctcactgtgg gcgctgcgta cctatgcaag tgcctagcta      780

tgaagtccca ggcgtaaagg gggatgttct atgccggctg agcgagaaaa agaggaatat      840

gaaacaatct ggggaaatgg ccatacatgg tggctgacgc ctgtaatccc agcactttgg      900

gaggccgagg caggagaatc gcttgagccc aggagttcga gaccagcctg gacaacatag      960

tgagaccccg tctatgcaaa aaatacacaa attagcctgg tgtggtggcc cgcacctgtg     1020

gtcccagcta cccgggaggc tgagttggga ggatcctttg agccctgaaa gtcgaggttg     1080

cagtgagcct tgatcgtgcc actgcactcc agcctggggg acagagcacg accctgtctc     1140

caaaaataaa ataaaaataa aaataaatat tggcggggga accctctgga atcaataaag     1200

gcttccttaa cca                                                        1213


<210>  7
<211>  1452
<212>  PRT
<213>  Homo sapiens

<400>  7

Gly Phe Pro Arg Asp Leu Glu Val Glu Arg Arg Ala Gln Gln Asn Ala 
1               5                   10                  15      


Ser Arg Gln Pro Pro Pro Lys Gln Glu Val Ala Phe Gly Arg Leu His 
            20                  25                  30          


Ile Asn Arg His His Gln Lys Glu Lys Gly Arg Arg Arg Gln Gln Arg 
        35                  40                  45              


Leu Gly Ser Cys Leu Gln Phe Gln Leu Gln Arg Asp Thr Phe Val Ala 
    50                  55                  60                  


Ser Arg Leu Gly Leu Cys Arg Glu Gly Pro Glu Gly Ala Asn Arg Arg 
65                  70                  75                  80  


Gly Ala Gln Met Ser Ser Cys Thr Pro Thr Pro Pro Thr Leu Gly Phe 
                85                  90                  95      


Val His Arg Pro Val Ile Cys Phe Ser Asp Leu Phe Cys Ile His Gly 
            100                 105                 110         


Glu Glu Arg Ser Glu Glu Glu Asn Lys Val Thr Pro Gly Gly Ser Glu 
        115                 120                 125             


Glu Leu Trp Pro Thr Pro Pro Val Pro Thr Ala Ala Ala Thr His Val 
    130                 135                 140                 


His Cys Ser Pro Asp Trp Arg Asp Ala Gly Ser Gly Ser Glu Asp Gly 
145                 150                 155                 160 


Ala Arg Thr Gly Ser Arg Ser Phe Leu Glu Val Met Asp Val Gly Ala 
                165                 170                 175     


Leu Ala Ser Gly Gln Ile Arg Thr Gln Arg Glu Leu Ser Arg Ser His 
            180                 185                 190         


His Leu Gln Leu Ser Leu Cys Leu Ala Ala Gly Leu Thr Leu Pro Val 
        195                 200                 205             


Cys Ser Phe Asp Asn Phe Gln Cys Arg Glu Phe Gln Tyr Asn Val Glu 
    210                 215                 220                 


Met Asp Thr Asp Thr Leu Cys Leu Ser Leu Ser Pro Pro Ala Gly Leu 
225                 230                 235                 240 


Leu Leu Leu Leu Leu Val Ala Leu Phe Gly Val Phe Val Pro Cys His 
                245                 250                 255     


Leu Pro Ser Ser Trp Ser Gly His Gly Val Thr Gly Gly His Gln Leu 
            260                 265                 270         


Leu Phe Phe Leu Leu Val Leu Leu Leu Ser Phe Gln Cys Gly Lys Ala 
        275                 280                 285             


Cys Ala Glu Leu Gln Ser Pro Pro Arg Arg Cys Pro Leu Glu Lys Ala 
    290                 295                 300                 


Val Leu Leu His Gln Val Leu Ser His Asp Glu Glu Arg Gln Gly Gln 
305                 310                 315                 320 


Arg Asp Gln Glu Arg Leu Ser Val Gln Cys Pro Gly Asp Asn Ile Ser 
                325                 330                 335     


Gly Asn Arg Ser Cys Cys Arg Gln Ser His Gln Gln Gln Leu Leu Leu 
            340                 345                 350         


Ser His Glu Gln Glu Gly Glu Thr Leu Trp Leu Lys Arg Val Gln Arg 
        355                 360                 365             


Leu Ala Glu Arg Glu Asn Arg Gly Lys Trp Ile Gln His Leu Cys Ile 
    370                 375                 380                 


Phe Leu Ala Ala Gln Trp Gln Ala Asn Val Cys Gly Ile Glu Trp Lys 
385                 390                 395                 400 


Arg Ser Ser Gln Glu Arg Thr Lys Asn Lys Lys Glu Lys His Leu Cys 
                405                 410                 415     


Ser Leu Pro Pro His Asp Asp Pro Asn Ile Glu Glu Asn Thr Val Gly 
            420                 425                 430         


Gly Cys Ser Thr Thr Asn Asp Ser Leu Asp Arg Lys Arg Trp Tyr Pro 
        435                 440                 445             


His Arg Leu Leu Lys Arg Gln Arg His Ser Pro Glu Phe Ser Leu Phe 
    450                 455                 460                 


Lys Gly Arg Lys Ala Leu Asp Val Phe Val Leu Thr Ala Asp Ile Gln 
465                 470                 475                 480 


Ser Ser Phe His Leu Cys Val Ile Val Ser Cys Leu Ile Ile Lys Ile 
                485                 490                 495     


Glu Ala Ser Gln Val Trp Met Glu Val Ile Leu Lys Thr Met Leu Trp 
            500                 505                 510         


Trp Gly Leu Gly Phe Phe Cys Leu Phe Val Cys Phe Ile Phe Lys Phe 
        515                 520                 525             


Leu Phe Leu Asn Phe Asp Arg Thr Arg Thr Trp Asn Thr Leu Leu Asn 
    530                 535                 540                 


Asp Leu Trp Glu Ser Tyr Leu Trp Asn Met Asn Thr Tyr Gln Arg Leu 
545                 550                 555                 560 


Ser Leu Leu Ile Gln Ala Phe Asn Glu Gln Asp Thr Gln Ala Phe Thr 
                565                 570                 575     


Gly Lys His Leu Gly His Ile Ile Cys Thr Thr Lys Gly Ala Leu Gly 
            580                 585                 590         


Val Ala Pro Trp Lys Asn Trp Ile Arg Phe Thr Asn Ile Asn Ile Val 
        595                 600                 605             


Val Asn Cys Pro Asn Thr Asn Ser Met Val Cys Leu Cys Ile Leu Ser 
    610                 615                 620                 


Pro Ser Phe Ser Ile Ser Phe Val Ile Tyr Leu Ile Gly Cys Ile Ser 
625                 630                 635                 640 


Phe Gly Val Arg Val Ser Ser Met Leu Pro Ser Gly Leu Pro Phe Leu 
                645                 650                 655     


Ser Leu Ser Leu Ser Leu Ser Leu Ser Leu Ser Leu Ser Leu Ser Leu 
            660                 665                 670         


Ser Leu Ser Leu Ser Leu Ser Pro Ser Leu Ser Leu Pro Pro Pro Ser 
        675                 680                 685             


Gly Thr Ile Arg Thr Phe Met Thr Lys Cys Phe Lys Thr Leu Ala Asn 
    690                 695                 700                 


Thr Ser Glu Ile Gly Asp Glu Ile Lys Glu Ala Val Met Pro His Ala 
705                 710                 715                 720 


Leu Ser Val Asp Leu Ile Cys Thr Ser Ala Ile Lys Asn Thr Ser Asn 
                725                 730                 735     


Asp Tyr Gly Arg Ile Leu Leu Ile Met Gln Ile Ser Val Ile Ile Cys 
            740                 745                 750         


Gln His Ile Ser Val Gln Arg Asp Pro Tyr Leu Lys Met Lys Ala Lys 
        755                 760                 765             


Phe Ser Phe Ile Val Leu Phe His Leu Gln Glu Tyr Thr Lys Arg Arg 
    770                 775                 780                 


Lys Asn Glu Leu Leu Asp His Cys Trp Val Phe Phe Phe Leu Leu Met 
785                 790                 795                 800 


Met Ala Cys His Arg Ser Gln Trp Gln Met Met Gln Arg Leu Ser Ala 
                805                 810                 815     


His Thr Ala Leu Cys Lys Ala His Arg Ile Leu Leu Pro Gln Lys Asn 
            820                 825                 830         


Gln Lys Arg Lys Phe Gly Met Lys Cys Asn Ser Pro Trp Gly Leu Thr 
        835                 840                 845             


Ala Asn Ile Ser Tyr Met Ser Asn His Ile Leu Thr Pro Val Gln Ala 
    850                 855                 860                 


Glu Trp Ser Ser Leu Tyr Arg Thr Thr Thr Leu Phe Ser Val Asn Leu 
865                 870                 875                 880 


Lys Cys Ser Arg Arg Phe His Asn Ile Thr Thr Leu Lys Phe Ile Phe 
                885                 890                 895     


Leu Glu Lys Val Lys Ala Val Cys Lys Cys Ala Met His Pro Arg Ser 
            900                 905                 910         


Val Asp His Ile Asn Thr Ala Leu Phe Ala Val Ser Val Val Ile Leu 
        915                 920                 925             


Arg Met Glu Thr Leu Leu Lys Lys Phe Arg Ile Thr Leu Arg Tyr Cys 
    930                 935                 940                 


Cys Ser Leu Leu Ser Cys Leu Glu Met Ser Val Tyr Phe His Cys Leu 
945                 950                 955                 960 


Asp Ser Val Phe Glu Gln Lys Asp Ser Pro Asn Val Ser Val Tyr Asn 
                965                 970                 975     


Leu Thr Ser Arg Glu Ala Ser Asp Leu Ser Ser Ser Asn Leu Phe Val 
            980                 985                 990         


Leu Met Leu Asp Gln Tyr Lys Ser  Ala Phe Asn Ile Ile  Ile Lys Gly 
        995                 1000                 1005             


Ser Val  Ile Leu Lys Leu Ala  Phe Phe Phe Arg Met  Phe Leu Gln 
    1010                 1015                 1020             


Val Ile  Ile Tyr Asp Phe Phe  Glu Lys Leu Ala Phe  Gln Glu Lys 
    1025                 1030                 1035             


Ser Thr  Glu Ala Gln Cys Phe  Gly Leu Trp Val Val  Ala Phe Cys 
    1040                 1045                 1050             


Gly Val  Leu Ser Thr Cys Phe  Leu Thr Asn Gly Ile  Phe Lys Met 
    1055                 1060                 1065             


Tyr Thr  Ser Cys Gly Trp Ile  Leu Tyr Val Arg Val  Leu Val Thr 
    1070                 1075                 1080             


Glu Ser  Lys Gly Ser Asn Val  Met Asn Leu Lys Asn  Val Ser Phe 
    1085                 1090                 1095             


Phe Thr  Phe Ile Leu Lys Leu  Tyr Leu Thr His Asp  His Gly Pro 
    1100                 1105                 1110             


Pro Thr  Thr Lys Ile Lys Cys  Leu Gly Arg Gln Thr  Ile Val Phe 
    1115                 1120                 1125             


Ser Asp  Lys Gly Asn Ser Lys  Cys Arg Arg Trp Ile  Leu Ile Ser 
    1130                 1135                 1140             


Leu Cys  His Leu Asp Tyr Arg  Asp Tyr Val Thr Val  Ile Ile Ile 
    1145                 1150                 1155             


Val Leu  Lys Thr Leu Asn Ser  Phe Gln Asn Val Ser  Lys Leu Ala 
    1160                 1165                 1170             


Glu Ser  Lys Asn Arg Lys His  Leu Ser Pro Ser Pro  Thr Leu His 
    1175                 1180                 1185             


Phe Pro  Leu Tyr Ala Ser Gln  Arg Ile Gln Asn Glu  Phe Gly Lys 
    1190                 1195                 1200             


Glu Arg  Gly Asp Ser Ser Ser  Leu His Ile Cys Leu  Ile Leu Ile 
    1205                 1210                 1215             


Glu Asn  Ser Gly Pro Phe Tyr  Asn Tyr Lys Lys Arg  Ser Ser Val 
    1220                 1225                 1230             


Leu Asn  Phe Val Cys Lys Lys  Lys Arg Phe Cys Glu  Phe Cys Leu 
    1235                 1240                 1245             


Arg Gly  Lys Cys Gly His Cys  Ser Thr Met Leu Lys  Cys Val Ser 
    1250                 1255                 1260             


His Gly  Tyr Arg Ala Tyr Asp  Cys His Gln Thr Pro  Arg Tyr Arg 
    1265                 1270                 1275             


Ile Ala  Ser Leu Leu Leu Ile  Leu Lys Arg Leu Asn  Ser Val Tyr 
    1280                 1285                 1290             


Tyr Val  Thr Phe Lys Arg Gln  Lys Cys Trp Glu Lys  Arg Ile Lys 
    1295                 1300                 1305             


Val Leu  Phe Leu Phe Tyr Phe  Leu Ser Phe Phe Ser  Ser Leu Phe 
    1310                 1315                 1320             


Phe Ser  Phe Leu Phe Phe Phe  Phe Ser Phe Phe Phe  Leu Phe Phe 
    1325                 1330                 1335             


Phe Tyr  Pro Lys Thr Ile Pro  Gly Asn Glu Ile Ser  Ser Arg Ala 
    1340                 1345                 1350             


Val Cys  Met Ala Gly Cys Gly  Met Pro His Ser Pro  Lys Gln Gln 
    1355                 1360                 1365             


Gln Gln  Lys Lys Lys Leu Leu  Lys His Leu Gly Phe  Phe Asn Val 
    1370                 1375                 1380             


Leu His  Val Ala Gly Tyr Pro  Tyr Pro Asn Asn Asn  Gln Met Leu 
    1385                 1390                 1395             


Ser Gly  Ser Pro Asn Tyr Ser  Gly Pro Pro Ser Leu  His Ser Gly 
    1400                 1405                 1410             


Arg Arg  Met Asn Lys Gln Gly  Trp Leu Val Gln Gln  Glu Ala Leu 
    1415                 1420                 1425             


Gly Gly  Lys Pro Gly Ala Ala  Asn Val Asp Phe Gln  Gly Met Glu 
    1430                 1435                 1440             


Lys Thr  Asn Glu Phe Asp Leu  Lys Ser 
    1445                 1450         


<210>  8
<211>  4572
<212>  DNA
<213>  Homo sapiens

<400>  8
ggctttccaa gggacttgga ggtggagaga agggcccaac aaaacgccag ccgccagccg       60

ccccccaaac aagaagtggc tttcggaaga cttcacatca acaggcacca ccaaaaagag      120

aaaggaagga gaagacaaca gcgcctgggc agctgcctcc agttctgaca actccaaaga      180

gacacttttt aagtggccag caggctggga ctctgcagag aaggaccaga aggtgccaac      240

cgcagagggg cgcagatgtc ttcctgcacc cccaccccac ccactttggg ttttgttcac      300

cgtcctgtca tctgtttttc agacctcttt tgcatctaac atggtgaaga aaggagtgaa      360

gaagagaaca aagtaacccc cggggggagc gaagagctct ggtgaccgac accaccagtt      420

cctactgccg cggccaccca cgtccactgt tcaccctgag actggagaga cgcaggcagc      480

ggatccgagg acggagcgag gacaggcagc cggtccttcc tagaagttat ggatgttggt      540

gcactcgctt ctggccagat ccgtacccag agggagctat ccagaagcca ccacctccag      600

ctgtctctct gcctcgcagc aggtcttacc cttccagtat gttccttctg atgagacaat      660

ttccagtgcc gagagtttca gtacaatgtg gaaatggata ctgacacatt gtgcctcagc      720

ctttccccac ctgccgggct gctgttgctg cttcttgttg ctctttttgg tgtcttcgtt      780

ccctgtcacc tgccaagctc ttggtcagga catggtgtca caggaggcca ccaactgctc      840

ttcttcctcc tcgtccttct cctctccttc cagtgcggga aggcatgtgc ggagctacaa      900

tcacctccaa ggagatgtcc gctggagaag gctgttctcc ttcaccaagt actttctcac      960

gattgagaag aacggcaagg tcagcgggac caagaatgaa gactgtccgt acagtgtcct     1020

ggagataaca tcagtggaaa tcggagttgt tgccgtcaaa gccatcaaca gcaactatta     1080

cttagccatg aacaagaagg ggaaactcta tggctcaaaa gagtttaaca acgactgtaa     1140

gctgaaagag agaatagagg aaaatggata caacacctat gcatctttta actggcagca     1200

caatggcagg caaatgtatg tggcattgaa tggaaaagga gctcccagga gaggacaaaa     1260

aacaagaagg aaaaacacct ctgctcactt cctccccatg acgatccaaa catagaagaa     1320

aacactgttg gtggatgcag tacaaccaat gactctttgg acagaaagag atggtatcct     1380

cactgaagac tgtagctcaa aaggcaaaga catagccctg aattcagctt gtttaaagga     1440

aggaaggctt tggatgtttt tgtactcact gctgacatac aaagttcttt tcactagctc     1500

tgtgtcattg tgtcatgcct tataatcaag atagaggcaa gtcaagtttg gatggaagtt     1560

atcctcaagt gaacaatgtt gtggtggggg ctgggctttt tttgtttgtt tgtttgtttc     1620

atttttaagt ttttgttttt gaacttctga gatagaactt aaagaacatg gaacactctg     1680

ttgaatgatc tttgggaaag ttatttatgg aatatgaaca catatcaaag actttcattg     1740

ctcattcaag cctgatgatt caatgagcag taagacacgc aagcatttac tggaaagcac     1800

ttgggtcata tcatatgcac aaccaaagga gctttgggtg tggcaccatg gaagaattgg     1860

atcagattta caaatataaa catagtagta tgaaactgtc ctaatacaaa tagtatggta     1920

tgcttgtgca ttctgtctcc atccttttct atttccttct aagttattta tttaatagga     1980

tgttaaatat cttttggggt ttaaagagta tcttcaatgc tgccctctgg tttacctttt     2040

ctctctctct ctctctctct ctctctctct ctctctctct ctctctctct ctctctctct     2100

ctctctctct ctccctctct ctccctccct cccccctctg gcaccatacg cacattcatg     2160

acaaagtgtt ttaaaacctt ggcaaacact tcagaaatag gagatgagat caaggaagca     2220

gtatgaatgc cccatgcgct ctcagttgac ttaatttgca cttctgcaat aaaaaacacc     2280

agcaatgact atggcagaat tctgctatag attatgtaac agatatctgt catcatttgt     2340

caacatatat cagtccagag ggacccttac cttaaaatgt agaaggccaa attctctttc     2400

attgtcttat ttcatcttca agaatatact aaaagaagaa aaaatgaatt gttagactaa     2460

cattgttggg tttttttttt cctactgatg atggcttgcc acaggtcaca atggcaaatg     2520

atgcaaaggt tatctgcaca tacatgagcc ctttgtaagg cccacagaat ccttctccct     2580

caaaagaacc aaaaaaggaa atttggtatg aagtgcaact ctccctgggg cttaacctga     2640

gcaaatatat cctagtatat gagtaaccat atactgacac ctgttcaagc tgaatggtct     2700

agtctttaca gaaccacata aaccttgttt tctgtaaatt taaaatgttc tagaaggttc     2760

cataatataa ccacattgaa attcattttc ttagaaaagg tatagaaagc agtatgtaag     2820

tgtgccatgc accctcgctc tgtagatcac taaataaaca cgtaagcctt atttgcagtg     2880

tctgtagtga ttttaagaat gtaggaaaca cttctaaaaa aattttaaag gataactctg     2940

agatgatatt gatgctgcag tcttctttct tgtttggaaa tgtctgttta ttttcattgt     3000

ttggattcag tattttgata ggaacaaaaa gactcaccaa atgtgtctgt ttactaaaat     3060

ttaacctcta gagaggctag tgatttgtga tcctcttcta acttatttgt gctgatgctt     3120

gaccagtaca aatcagcttt ttaaaatatt attattaaag gttgatcagt cattttaaaa     3180

ttggcctttt ttttcagaat gttcctacag gtcataattt atgatttctt tgaaaagctt     3240

gcatttcaag agaaaagcac agaggcacaa tgctttggtt tatgggtata ggttgcattt     3300

tgtggtgttc tttcaacttg ttttctgaca aatgggattt ttaaaatgta tacttcttgt     3360

ggttggattc tgtatgttag agtttaattg gtaactgagt ctaaaggctc taatgtaatg     3420

aatctctaga agaactaggt atcttttttt acttttattt taaaataata attatacctg     3480

acacatgacc atggaccacc cacaaccaaa attaaatgtt tggggagaca aactatagta     3540

ttcagtgaca agggtaacag caaatagtgc agacgttgga ttcttatttc actttgccat     3600

ttagattact aaagagacta tgtgtaaaca gtcatcatta tagtactcaa gacattaaac     3660

agcttctagc aaaatgtatc aaagcttgca gagtccaaaa atagaaaaca tctttccccc     3720

tctcccaccc tacatttccc cctgtatgca tcctaacaga gataaataca aaatgaattc     3780

ggtaaggaga gaggagattc ttcttcactt catatttgtt tgatattaat agagaattct     3840

ggtccttttt acaactactg aaagaaaaga agttcagtcc taaattttgt gtgttaaaaa     3900

aagaaaagat tttgtgagtt ctgcctccgt gggaagtgtg ggcactgctc caccatgctg     3960

aagtgtgtta gccacgggta cagagcatat gactgttgac atcagactcc ttaaagatac     4020

agaatcgctt ccctcctcct aatcctcaaa aggctgaaca gtgtatatta tgttacattt     4080

aaataaaggc aataaaaatg ctgggaaaag agaataaaag tactgttctt attttatttc     4140

ctttctttct tctcttctct tttcttttct ttccttttct tttttttttc cttttttttt     4200

cttttttttt tttattagcc taaaactata cctggtaatg agatcagctc cagggctgtg     4260

tgcatggcag gatgtggtta aatgccccac agccccaaac aacaacaaca gaaaaaaaaa     4320

ttactcaaac atttgtaagg tttctttaat gttttacatg tgtgagccgg ctatccttac     4380

cctaataaca accaaatgct ttcgggttct cctaactact caggtccacc tagtttacac     4440

agtggataaa gaagaatgaa ttgaaaacaa ggatggcttg tgcaacaatg agaggctctt     4500

ggaggaaagc caggagctgc aaacgttgac ttccagggca tggaaaagac caacgaattt     4560

gatttgaaaa gt                                                         4572


<210>  9
<211>  1664
<212>  PRT
<213>  Homo sapiens

<400>  9

Thr His Thr His Lys His Thr Arg Ala His Thr Gln Arg Glu Asn Pro 
1               5                   10                  15      


Ser Ala Cys Phe Met Glu Thr Ile Met Ile Leu Leu Glu Asn Phe Ser 
            20                  25                  30          


Ala Glu Lys Phe Val Ala Thr Val Glu Arg Leu Lys Leu His Gln Ala 
        35                  40                  45              


Asp Asn Arg His Gly Ile Leu Ile Tyr Pro Ala Val Ser Asn Lys Thr 
    50                  55                  60                  


Lys Val Lys Gln Thr Ala Ser Gln Gln Leu Asn Leu Leu Arg Thr Val 
65                  70                  75                  80  


Phe Met Arg Ile Tyr Gln Gln Ser Tyr Leu Arg Arg Asn Pro Val Leu 
                85                  90                  95      


Leu Ser Gly Thr Lys Arg Ile Arg Leu Thr Ile Trp Lys Glu Gln Leu 
            100                 105                 110         


Leu Phe Leu Lys Ser Ile Tyr Asn Ser Gln Ile Gly Arg Gly Gln Pro 
        115                 120                 125             


Arg Ser Asn Asn Gln Leu Lys Ile His Phe His Tyr Val Ile His Glu 
    130                 135                 140                 


His Pro Glu His Tyr Thr Ile Met His Lys Trp Ile Leu Thr Trp Ile 
145                 150                 155                 160 


Leu Pro Thr Leu Leu Tyr Arg Ser Cys Phe His Ile Ile Cys Leu Val 
                165                 170                 175     


Gly Thr Ile Ser Leu Ala Cys Asn Asp Met Thr Pro Glu Gln Met Ala 
            180                 185                 190         


Thr Asn Val Asn Cys Ser Ser Pro Glu Arg His Thr Arg Ser Tyr Asp 
        195                 200                 205             


Tyr Met Glu Gly Gly Asp Ile Arg Val Arg Arg Leu Phe Cys Arg Thr 
    210                 215                 220                 


Gln Trp Tyr Leu Arg Ile Asp Lys Arg Gly Lys Val Lys Gly Thr Gln 
225                 230                 235                 240 


Glu Met Lys Asn Asn Tyr Asn Ile Met Glu Ile Arg Thr Val Ala Val 
                245                 250                 255     


Gly Ile Val Ala Ile Lys Gly Val Glu Ser Glu Phe Tyr Leu Ala Met 
            260                 265                 270         


Asn Lys Glu Gly Lys Leu Tyr Ala Lys Lys Glu Cys Asn Glu Asp Cys 
        275                 280                 285             


Asn Phe Lys Glu Leu Ile Leu Glu Asn His Tyr Asn Thr Tyr Ala Ser 
    290                 295                 300                 


Ala Lys Trp Thr His Asn Gly Gly Glu Met Phe Val Ala Leu Asn Gln 
305                 310                 315                 320 


Lys Gly Ile Pro Val Arg Gly Lys Lys Thr Lys Lys Glu Gln Lys Thr 
                325                 330                 335     


Ala His Phe Leu Pro Met Ala Ile Thr Leu His Met Val Tyr Lys Glu 
            340                 345                 350         


Pro Val Pro Ala Gly Arg Phe Leu Val Asp Cys Phe Leu Ser Ser Gln 
        355                 360                 365             


Asn Phe Leu Ser Phe Tyr Phe Leu Val Ile Lys Lys Gly Trp Lys Thr 
    370                 375                 380                 


Thr Glu Lys Leu Ile Lys Leu Asp Leu Cys Ile Tyr Val Cys Phe Lys 
385                 390                 395                 400 


Thr Leu His Arg Lys Ile Lys Val Tyr Thr Lys Ile Arg Phe Ser Asn 
                405                 410                 415     


Arg Leu Lys Ile Val Lys Leu Val Val Gln Ser Cys Gln Phe Phe Ser 
            420                 425                 430         


Ile Asn Leu Pro Leu Arg Val Cys Ile Leu Ser Asp Asn Asp Tyr Leu 
        435                 440                 445             


Asn Ile Pro Ile Cys Leu Asn Gly Cys Tyr Asn Asn Asn Asn Thr Asp 
    450                 455                 460                 


Val Val Ile Gly Ile Ser Asp Leu Gln Ala Ser Gly Arg Ile Cys Gln 
465                 470                 475                 480 


Ile Ile Lys Pro His Leu Trp Lys Met Ser Ser Ile Leu Asn Ala Phe 
                485                 490                 495     


Lys Ile Ile Ile Tyr Leu Asn Ser Asn Gln Lys Lys Asn Ser Gln Lys 
            500                 505                 510         


Asn Tyr Tyr Glu Ser Gln Asn Arg Phe Asn Lys Ser Thr Gly Leu Glu 
        515                 520                 525             


His Ala Tyr Thr Tyr Lys Glu Gln Asn Phe Cys Cys Ser Ser Gly Lys 
    530                 535                 540                 


Gly Ile Ala Lys Arg Met Phe Pro Lys Ile Leu Tyr Ile Arg Gln Gln 
545                 550                 555                 560 


Leu Met Ile Ile Leu Tyr Phe Ile Leu Leu Ala Thr Lys His Phe Ile 
                565                 570                 575     


Asn Pro Gln Ser Lys Ile Glu Lys Ser Leu Ser Phe Phe Gln Val Thr 
            580                 585                 590         


Ser Ile Phe Val Phe Ile Phe Gly Asn Met Ala Phe Asn Asn Val Leu 
        595                 600                 605             


Pro Thr Asn Asn His Ala Phe Phe Leu Trp Leu Gln His Thr Leu Phe 
    610                 615                 620                 


Val Val Phe Glu Leu Tyr Cys Phe Val Ile Val Tyr Val Ile Tyr Lys 
625                 630                 635                 640 


Lys Lys Thr Leu Ile Ser Cys Ile Cys Phe Ile Cys Phe Phe Arg Asn 
                645                 650                 655     


Asn Lys Thr Val Trp Leu Asn Gly Lys Phe Pro Ser Leu Phe Leu Thr 
            660                 665                 670         


Leu Ser Leu Ala His Ser Thr Trp Ala Ser Lys Ser Trp Lys Ala Asp 
        675                 680                 685             


Lys Asn Lys Ser Leu Lys Gln Cys Leu Gln Met Ser His Thr Glu Gln 
    690                 695                 700                 


Tyr Lys Tyr Val Lys Asn Leu Ser Pro His Ile Leu Ala Asn Leu Asp 
705                 710                 715                 720 


His Ile Ser Lys Ile Ile Thr Asn Ile Ser Ile Tyr Arg Ile Leu Lys 
                725                 730                 735     


Leu Glu Tyr Ile Met His Gly Lys Ile Ser Tyr Phe Lys Thr Met Tyr 
            740                 745                 750         


Ile Ile Phe Ser Asn Leu Lys Ser Leu Leu Phe Lys Arg Trp Gln His 
        755                 760                 765             


Lys Leu Phe Ser Cys Met Ala Arg Ala Gln Cys Pro Lys Lys Met Gln 
    770                 775                 780                 


Leu Arg Ile Arg Gly Pro Glu Cys His Glu Gly Leu Arg Ser Ala Tyr 
785                 790                 795                 800 


Arg Gln Asp Tyr Tyr Lys Asp Glu Phe Pro Leu Gln Lys Ser Phe Ile 
                805                 810                 815     


Gly Arg Ser Trp His Phe Ile Cys Ser Pro Met Gly Gly Gln Tyr Leu 
            820                 825                 830         


Ser Asn Leu Lys Gly Met Leu Thr Thr Val Val Leu Ile Ser Lys Tyr 
        835                 840                 845             


Leu Ser Phe Lys Ser Leu Tyr Ile Asn Ser Ile Trp Tyr Ile Tyr Arg 
    850                 855                 860                 


Glu Leu Tyr Glu Lys Ala Arg Ser Thr Lys Thr Ile Asp Ser Phe Asn 
865                 870                 875                 880 


Phe Pro Val Val Asp Leu Tyr Asp Gln Asp Val Glu Asn Lys Glu Leu 
                885                 890                 895     


Pro Phe Leu Arg Tyr Thr Leu Gly Arg Glu His Glu Trp Tyr Ser Glu 
            900                 905                 910         


Leu Ser Pro Asp Ser Arg Thr Leu Leu Ala Arg Phe Gly Gln Ala Ser 
        915                 920                 925             


Val Thr Val Val Leu Ala Tyr Gly Gln Arg Arg Thr Phe Phe Ile Cys 
    930                 935                 940                 


Val Ser Leu Val Pro Ser Arg Leu Ser Val His Asn Gln Phe Ser Val 
945                 950                 955                 960 


Ile His Met Phe Ile Asp Lys Arg Lys Tyr Thr Leu Lys Leu Ile Phe 
                965                 970                 975     


Ile Leu Lys Gly Asn Met Thr Ile Gln Lys Phe Lys Lys Cys Ile Tyr 
            980                 985                 990         


Ile Asn Thr Ser Tyr Val Arg Thr  Lys Cys Ser Leu Ser  Met Glu Leu 
        995                 1000                 1005             


Tyr Phe  His Gln Ile Thr Gln  Cys Ile Arg Gln Asn  Gln His Leu 
    1010                 1015                 1020             


Val Val  Asn Pro Phe Leu Val  Val Val Thr Lys Arg  Leu Leu Glu 
    1025                 1030                 1035             


Ile Cys  Thr Leu Ile Ile Cys  Phe Ser Pro Ile Phe  Lys Phe Ile 
    1040                 1045                 1050             


Met Gln  Ile Leu Glu Asn Lys  Ile Cys Ser Ser Tyr  Thr Pro Leu 
    1055                 1060                 1065             


Glu Phe  Asn Ile Lys Thr Val  Arg Gly Leu His Pro  Ser Tyr Ser 
    1070                 1075                 1080             


Phe Val  Val Glu Ile Glu Ile  Leu Ile His Leu Arg  Ser Arg Ser 
    1085                 1090                 1095             


Trp Val  Asp Ile Gln Leu Ser  Gln Glu Ser Arg Ser  Val Ser Thr 
    1100                 1105                 1110             


Cys Phe  Leu Leu Phe Asp Tyr  Tyr Tyr Leu Met Val  Phe Gly Met 
    1115                 1120                 1125             


Phe Leu  Phe Phe Ile Ser Val  Glu Ile Pro Leu His  Leu Tyr Thr 
    1130                 1135                 1140             


Asn Val  Thr Met Ser Trp Gln  Cys Thr Ser Tyr Thr  Met Thr Asn 
    1145                 1150                 1155             


Leu Tyr  Cys Asp Asp Leu Thr  Gln Lys Glu Lys Arg  Asn Tyr Val 
    1160                 1165                 1170             


Val Phe  Asn Ser Asp Ser Tyr  Ser Pro Phe Val Tyr  Glu Trp Lys 
    1175                 1180                 1185             


Ala Leu  Cys Lys Ile Tyr Ile  Ala Glu Ala Phe Lys  Cys Ser Leu 
    1190                 1195                 1200             


Lys Asp  Lys Ile Lys Tyr Met  Ser Phe Gln Leu Glu  Lys Lys Lys 
    1205                 1210                 1215             


Leu Lys  His Glu Met Ile Thr  Lys Val Asn Lys Arg  Tyr Phe Gln 
    1220                 1225                 1230             


Ser Ser  Glu Gln Asn Ile Leu  Thr Ala Ile Ile Ile  Ile Ile Lys 
    1235                 1240                 1245             


Ile Lys  Thr Ile Val Ile Val  Ser Leu Val Gly Tyr  Lys Phe Asn 
    1250                 1255                 1260             


Leu Met  Thr Glu Glu Lys Gly  Cys Trp Arg Ile Leu  Arg Val Ser 
    1265                 1270                 1275             


Ile Ser  Ser Leu Leu Phe Trp  Phe Ser Arg Leu Pro  Lys Asn Ile 
    1280                 1285                 1290             


Lys Met  Cys Glu Gly Thr Leu  Lys Gln Ser Tyr Asn  Lys Lys Asn 
    1295                 1300                 1305             


Ser Lys  Thr Val Pro Leu Thr  Ile Phe Tyr Asn Phe  Ser Asn Ser 
    1310                 1315                 1320             


Arg Gly  Val Lys Glu Val Arg  Glu Cys Lys Gly Gly  Pro Pro Gln 
    1325                 1330                 1335             


Thr Glu  His Phe Phe Ser Leu  Lys Thr His Val Ile  Phe Ala Ser 
    1340                 1345                 1350             


Tyr Ser  Ile Ile Tyr Leu Trp  Leu Arg Tyr Asp Asn  Val Cys Asn 
    1355                 1360                 1365             


Thr Pro  Val Ser Lys Ile Asp  Thr Ser Glu Leu Ala  Gly Leu Ile 
    1370                 1375                 1380             


Met Gln  Phe Gly Leu His Pro  Tyr Ser Thr Ala Ile  Tyr Leu Ser 
    1385                 1390                 1395             


Val Asn  Glu Thr Gln Lys Ile  Ile Cys Leu Pro Ser  Asn Phe Thr 
    1400                 1405                 1410             


His Lys  His Lys Ala Lys Glu  Asn Gln Asn Ser Asn  Ser Pro Arg 
    1415                 1420                 1425             


Ile Gly  Val Ile Thr Lys Ile  Phe Asn Ser Gln Tyr  Gly Leu Leu 
    1430                 1435                 1440             


Ala Asn  Gln Asn Thr Ser Leu  Ile His Arg Asn Gly  Cys Arg Pro 
    1445                 1450                 1455             


Leu Leu  Thr Cys Gly Tyr His  Phe Tyr Asp His Pro  Lys Thr Glu 
    1460                 1465                 1470             


Leu Gly  Lys Tyr Leu Leu Thr  Gly Leu Ser Gly Leu  Asn Ser Gln 
    1475                 1480                 1485             


Tyr Val  Ser Tyr Glu Ile Ala  His Asn Phe Met Cys  Asn Tyr Phe 
    1490                 1495                 1500             


Ser Ile  Val Val Ser Tyr Ser  Leu Phe His Phe Cys  Thr Val Phe 
    1505                 1510                 1515             


Ile Gln  Pro Ser Cys Cys Phe  Gln Arg Ser Leu Val  Pro Ser Gly 
    1520                 1525                 1530             


Thr His  Ile Leu Pro Pro Ile  Leu Phe Met Val Cys  Gln Glu Asn 
    1535                 1540                 1545             


Leu Leu  Ser Leu Glu Leu Lys  Asn Leu Thr Gly Ser  Lys Lys Tyr 
    1550                 1555                 1560             


Ser Pro  Ser Leu Phe Pro Ile  Thr Ser Asp Phe Ser  Ile Leu Lys 
    1565                 1570                 1575             


Leu His  Phe Ser Arg Asn Gln  Ile Phe Thr Leu Ile  Trp Glu Asp 
    1580                 1585                 1590             


Ala Ser  Tyr Val Phe Leu Leu  Leu Pro Gly Tyr His  Val Val Ala 
    1595                 1600                 1605             


Phe Ser  Lys Phe Leu Ser Leu  Asn Leu Glu Pro Ile  Lys Ile Tyr 
    1610                 1615                 1620             


Phe Leu  Ser Phe Ile Phe Leu  Lys Cys Glu Met Lys  Ile Thr Phe 
    1625                 1630                 1635             


His Leu  Lys Thr Leu Leu Leu  Met Asn Pro Ser Met  Cys Leu Ser 
    1640                 1645                 1650             


Ile Ala  Val Gln Ile Lys Thr  Trp Leu Glu Thr 
    1655                 1660                 


<210>  10
<211>  5320
<212>  DNA
<213>  Homo sapiens

<400>  10
acacacacac acaagcacac acgcgctcac acacagagag aaaatccttc tgcctgttga       60

tttatggaaa caattatgat tctgctggag aacttttcag ctgagaaata gtttgtagct      120

acagtagaaa ggctcaagtt gcaccaggca gacaacagac atggaattct tatatatcca      180

gctgttagca acaaaacaaa agtcaaatag caaacagcgt cacagcaact gaacttacta      240

cgaactgttt ttatgaggat ttatcaacag agttatttaa gaggaatcct gtgttgttat      300

caggaactaa aaggataagg ctaacaattt ggaaagagca actactcttt cttaaatcaa      360

tctacaattc acagatagga agaggtcaat gacctaggag taacaatcaa ctcaagattc      420

attttcatta tgttattcat gaacacccgg agcactacac tataatgcac aaatggatac      480

tgacatggat cctgccaact ttgctctaca gatcatgctt tcacattatc tgtctagtgg      540

gtactatatc tttagcttgc aatgacatga ctccagagca aatggctaca aatgtgaact      600

gttccagccc tgagcgacac acaagaagtt atgattacat ggaaggaggg gatataagag      660

tgagaagact cttctgtcga acacagtggt acctgaggat cgataaaaga ggcaaagtaa      720

aagggaccca agagatgaag aataattaca atatcatgga aatcaggaca gtggcagttg      780

gaattgtggc aatcaaaggg gtggaaagtg aattctatct tgcaatgaac aaggaaggaa      840

aactctatgc aaagaaagaa tgcaatgaag attgtaactt caaagaacta attctggaaa      900

accattacaa cacatatgca tcagctaaat ggacacacaa cggaggggaa atgtttgttg      960

ccttaaatca aaaggggatt cctgtaagag gaaaaaaaac gaagaaagaa caaaaaacag     1020

cccactttct tcctatggca ataacttaat tgcatatggt atataaagaa ccagttccag     1080

cagggagatt tctttaagtg gactgttttc tttcttctca aaattttctt tccttttatt     1140

ttttagtaat caagaaaggc tggaaaacta ctgaaaaact gatcaagctg gacttgtgca     1200

tttatgtttg ttttaagaca ctgcattaaa gaaagatttg aaaagtatac acaaaaatca     1260

gatttagtaa ctaaaggttg taaaaaattg taaaactggt tgtacaatca tgatgttagt     1320

aacagtaatt tttttcttaa attaatttac ccttaagagt atgttagatt tgattatctg     1380

ataatgatta tttaaatatt cctatctgct tataaaatgg ctgctataat aataataata     1440

cagatgttgt tatataaggt atatcagacc tacaggcttc tggcaggatt tgtcagataa     1500

tcaagccaca ctaactatgg aaaatgagca gcattttaaa tgctttctag tgaaaaatta     1560

taatctactt aaactctaat cagaaaaaaa attctcaaaa aaactattat gaaagtcaat     1620

aaaatagata atttaacaaa agtacaggat tagaacatgc ttatacctat aaataagaac     1680

aaaatttcta atgctgctca agtggaaagg gtattgctaa aaggatgttt ccaaaaatct     1740

tgtatataag atagcaacag tgattgatga taatactgta cttcatctta cttgccacaa     1800

aataacattt tataaatcct caaagtaaaa ttgagaaatc tttaagtttt tttcaagtaa     1860

cataatctat ctttgtataa ttcatatttg ggaatatggc ttttaataat gttcttccca     1920

caaataatca tgcttttttc ctatggttac agcattaaac tctattttaa gttgtttttg     1980

aactttattg ttttgttatt taagtttatg ttatttataa aaaaaaaacc ttaataagct     2040

gtatctgttt catatgcttt taattttaaa ggaataacaa aactgtctgg ctcaacggca     2100

agtttccctc ccttttctga ctgacactaa gtctagcaca cagcacttgg gccagcaaat     2160

cctggaaggc agacaaaaat aagagcctga agcaatgctt acaatagatg tctcacacag     2220

aacaatacaa atatgtaaaa aatctttcac cacatattct tgccaattaa ttggatcata     2280

taagtaaaat cattacaaat ataagtattt acaggatttt aaagttagaa tatatttgaa     2340

tgcatgggta gaaaatatca tattttaaaa ctatgtatat ttaaatttag taattttcta     2400

atctctagaa atctctgctg ttcaaaaggt ggcagcactg aaagttgttt tcctgttaga     2460

tggcaagagc acaatgccca aaatagaaga tgcagttaag aataaggggc cctgaatgtc     2520

atgaaggctt gaggtcagcc tacagataac aggattatta caaggatgaa tttccacttc     2580

aaaagtcttt cattggcaga tcttggtagc actttatatg ttcaccaatg ggaggtcaat     2640

atttatctaa tttaaaaggt atgctaacca ctgtggtttt aatttcaaaa tatttgtcat     2700

tcaagtccct ttacataaat agtatttggt aatacattta tagatgagag ttatatgaaa     2760

aggctaggtc aacaaaaaca atagattcat ttaattttcc tgtggttgac ctatacgacc     2820

aggatgtaga aaactagaaa gaactgccct tcctcagata tactcttggg agagagcatg     2880

aatggtattc tgaactatca cctgattcaa ggactttgct agctaggttt tgaggtcagg     2940

cttcagtaac tgtagtcttg tgagcatatt gagggcagag gaggacttag tttttcatat     3000

gtgtttcctt agtgcctagc agactatctg ttcataatca gttttcagtg tgaattcact     3060

gaatgtttat agacaaaaga aaatacacac taaaactaat cttcatttta aaagggtaaa     3120

acatgactat acagaaattt aaatagaaat agtgtatata catataaaat acaagctatg     3180

ttaggaccaa atgctctttg tctatggagt tatacttcca tcaaattaca tagcaatgct     3240

gaattaggca aaaccaacat ttagtggtaa atccattcct ggtagtataa gtcacctaaa     3300

aaagacttct agaaatatgt actttaatta tttgtttttc tcctattttt aaatttatta     3360

tgcaaatttt agaaaataaa atttgctcta gttacacacc tttagaattc tagaatatta     3420

aaactgtaag gggcctccat ccctcttact catttgtagt ctaggaaatt gagattttga     3480

tacacctaag gtcacgcagc tgggtagata tacagctgtc acaagagtct agatcagtta     3540

gcacatgctt tctactcttc gattattagt attattagct aatggtcttt ggcatgtttt     3600

tgttttttat ttctgttgag atatagcctt tacatttgta cacaaatgtg actatgtctt     3660

ggcaatgcac ttcatacaca atgactaatc tatactgtga tgatttgact caaaaggaga     3720

aaagaaatta tgtagttttc aattctgatt cctattcacc ttttgtttat gaatggaaag     3780

ctttgtgcaa aatatacata taagcagagt aagcctttta aaaatgttct ttgaaagata     3840

aaattaaata catgagtttc taacaattag aaaagaaaaa attaaaacat gaaatgataa     3900

caaaagtaaa caaaagatac tttcaaagca gtgaacaaaa cattttgaca taagccataa     3960

tataaattat aatataaaaa ataaaaacca tagtataaat tgtcagcctt tgagttggct     4020

acaaattcaa tttaatgaca gaagagaagg gatgctggag gtaaattctt agggtttcta     4080

tctcatagag tttgctcttc tggttctcta gactgccaaa gaacataaag atgtgcgagg     4140

ggacctagct gtagtaaaag caatcctata acaagaaaaa ctctaaaaca gtgcccctta     4200

cgattttcta ctgaaatttc tctaatagta gaggtgtaaa ataagaagtt agagaataat     4260

gcaaaggggg cccaccacag acggaacatt tcttttctct taagactcat gtgatttttg     4320

catcttactc cataatatat ttgtggttgc gttaatatga caatgtctgc aattaaacac     4380

cagtaagcaa aattgataca tcagaatgac ttgcagggct tatcatgcag tttggtttac     4440

atccctactc cactgccatt tacttgagcg tgaatgagac acaaaagatt atttgcctcc     4500

cataatccaa ctttacacat aaataacaca aggctaaaga aaaccagaac tcaaattcac     4560

cacgcatagg agtgataaca aaaatattta acagtcagta tgggtgatta ctggccaatc     4620

agaatacatc actgatacat cgaaatggat gcaggccact atgactaact tgtgggtatc     4680

atttctatga tcaccctaaa acagagttgg gaaaatatct attaactggt ctctctggtt     4740

tgaattctca atatgtatct taatatgaaa tagctcatta aaacttcatg tgtaactatt     4800

tcagcattgt tgtcagctac tctttattcc acttctgtac agtatttatt caaccaagct     4860

gctgctttca atgaaggtca cttgttcctt cagggacaca tatactccca cctatccttt     4920

aattttgaat ggtttgtcag gaaaatttac tttctcttga gttgaaaaac ttgacaggaa     4980

gcaagaaata atacagtcct agcctctttc caataacatc tgatttctcc attctcaaac     5040

tacacttctc aaggaaccag atatttactc tcatctggga agatgcctct tatgttttcc     5100

ttttacttcc tggttatcat gtggttgcat tttccaagtt cttatcattg aatttatgag     5160

agcctatcaa aatttatttt ctttcattta tattctaata attgaaatgt gagatgaaaa     5220

taacatttca cttatgaaaa acccttctct tgatgaatcc ttccatgtgt tagttatcta     5280

ttgctgtgta acaaattaaa acttaatggc ttgaaacaaa                           5320


<210>  11
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  11

Thr Arg Ala Pro Ser Leu His Ser Ala Asn Cys Ser Leu Ala His Leu 
1               5                   10                  15      


Pro Pro Leu His His Asp His Leu Gln Pro Pro Val His Leu Leu Gln 
            20                  25                  30          


Leu His Glu Gly Leu Leu Arg His Arg Gly Arg His Arg Gly Arg Leu 
        35                  40                  45              


Gln Pro His Leu Leu Arg Pro Gly Arg Arg Val Leu Pro Arg Pro Gln 
    50                  55                  60                  


His Leu Arg Gly Arg Pro Val Cys Leu Ile Leu Pro Leu Leu Leu Trp 
65                  70                  75                  80  


Gly Ser Leu Arg Ala Gly Gly Arg Leu Trp Arg Trp Leu Gln Gln Gln 
                85                  90                  95      


Gln Gln Gln Leu Trp Trp Leu Trp Gly Arg Ile Trp Trp Trp Pro Trp 
            100                 105                 110         


Cys Trp Leu Gly Trp Trp Leu Trp Trp Trp Leu Cys Trp Trp Trp Ala 
        115                 120                 125             


Ser Gly Gly Gln Glu Gly Asp His Ala Glu Pro Gln Pro Pro Gly Leu 
    130                 135                 140                 


Leu Pro Gly Gln Gly Ala Cys Ser Gly Gly Gly Gln Arg Arg Pro Gly 
145                 150                 155                 160 


Ser Glu Asp Pro Leu Val Pro Glu Ala Ala Ala Cys Asp Gln Arg Leu 
                165                 170                 175     


Gln Ser Leu Leu Gln Asp His Gly Pro Glu Glu Gln Asp Ser His Ser 
            180                 185                 190         


His Ser Gly Gln Cys Gln Cys Pro Ser Ala Asp Gln Cys Pro Ser Gly 
        195                 200                 205             


Arg Gly Leu Pro His Gln Val Asp Arg Val Glu Pro Ala His Glu Cys 
    210                 215                 220                 


Gly Ser Arg His Gln Trp Pro Ala Gln Gly Ala Gly Arg Thr Asp Pro 
225                 230                 235                 240 


Gly Gln Ser Pro Gly Asp Ala Asp Glu Pro Glu Gly Gly Ala Gly Leu 
                245                 250                 255     


Pro Glu Glu Glu Pro Arg Gly Gly Asp Glu Cys Pro Glu Arg Pro Gly 
            260                 265                 270         


Gly Trp Arg Cys Gln Cys Gly Asp Gly Arg Cys Thr Trp Arg Gly Pro 
        275                 280                 285             


Glu Pro His Ser Glu Arg Asp Ala Pro Val Glu Asp Gly Arg Glu Glu 
    290                 295                 300                 


Pro Gln Gly Cys Arg Gly Met Val Leu His Gln Asp Arg Gly Ala Glu 
305                 310                 315                 320 


Pro Arg Gly Gly His Gln Gln Arg Ala Gly Ala Glu Arg Gln Glu Arg 
                325                 330                 335     


Asp Leu Gly Ala Pro Ala His His Ala Glu Pro Gly Asp Ala Ala Val 
            340                 345                 350         


Pro Ala Gln His Glu Ser Ile Pro Gly Glu Gln Pro Gly Gly Asp Gln 
        355                 360                 365             


Arg Ser Leu Leu His Ala Ala Gly Pro Asp Pro Gly Asp Asp Trp Gln 
    370                 375                 380                 


Arg Gly Gly Ala Ala Gly Pro Ala Pro Leu Arg Asp Gly Ala Ala Glu 
385                 390                 395                 400 


Pro Gly Val Gln Asp Pro Ala Gly Arg Glu Asp Ala Ala Gly Ala Gly 
                405                 410                 415     


Asp Arg His Leu Pro Pro Pro Ala Gly Gly Arg Gly Arg Pro Pro Leu 
            420                 425                 430         


Leu Leu Pro Val Leu Leu Trp Ile Ala Val Ile Gln Arg Cys Asp Leu 
        435                 440                 445             


Leu Gln Pro Pro Asn Pro His Gln Gly His Gly Cys Ala Arg Trp Gln 
    450                 455                 460                 


Gly Gly Val His Pro Arg Ala Gly Pro Ser His Gln Glu Leu Arg Leu 
465                 470                 475                 480 


Pro Ser Pro Ala Gln Ala Glu Ala Pro Arg Val Asp Thr Asp Pro Thr 
                485                 490                 495     


Gly Arg Ser Pro Leu Leu Pro Lys His Phe Thr Ala Gly Pro Cys Phe 
            500                 505                 510         


Thr Leu Thr Pro Ser Trp Gln Ser Ile Gln Leu His Tyr Leu Ser Cys 
        515                 520                 525             


Ile 
    


<210>  12
<211>  1636
<212>  DNA
<213>  Homo sapiens

<400>  12
acccgagcac cttctcttca ctcagccaac tgctcgctcg ctcacctccc tcctctgcac       60

catgaccacc tgcagccgcc agttcacctc ctccagctcc atgaagggct cctgcggcat      120

cgggggcggc atcgggggcg gctccagccg catctcctcc gtcctggccg gagggtcctg      180

ccgcgccccc agcacctacg ggggcggcct gtctgtctca tcctcccgct tctcctctgg      240

gggagcctgc gggctggggg gcggctatgg cggtggcttc agcagcagca gcagcagctt      300

tggtagtggc tttgggggag gatatggtgg tggccttggt gctggcttgg gtggtggctt      360

tggtggtggc tttgctggtg gtgatgggct tctggtgggc agtgagaagg tgaccatgca      420

gaacctcaat gaccgcctgg cctcctacct ggacaaggtg cgtgctctgg aggaggccaa      480

cgccgacctg gaagtgaaga tccgtgactg gtaccagagg cagcggcctg ctgagatcaa      540

agactacagt ccctacttca agaccattga ggacctgagg aacaagattc tcacagccac      600

agtggacaat gccaatgtcc ttctgcagat tgacaatgcc cgtctggccg cggatgactt      660

ccgcaccaag tatgagacag agttgaacct gcgcatgagt gtggaagccg acatcaatgg      720

cctgcgcagg gtgctggacg aactgaccct ggccagagct gacctggaga tgcagattga      780

gagcctgaag gaggagctgg cctacctgaa gaagaaccac gaggaggaga tgaatgccct      840

gagaggccag gtgggtggag atgtcaatgt ggagatggac gctgcacctg gcgtggacct      900

gagccgcatt ctgaacgaga tgcgtgacca gtatgagaag atggcagaga agaaccgcaa      960

ggatgccgag gaatggttct tcaccaagac agaggagctg aaccgcgagg tggccaccaa     1020

cagcgagctg gtgcagagcg gcaagagcga gatctcggag ctccggcgca ccatgcagaa     1080

cctggagatt gagctgcagt cccagctcag catgaaagca tccctggaga acagcctgga     1140

ggagaccaaa ggtcgctact gcatgcagct ggcccagatc caggagatga ttggcagcgt     1200

ggaggagcag ctggcccagc tccgctgcga gatggagcag cagaaccagg agtacaagat     1260

cctgctggac gtgaagacgc ggctggagca ggagatcgcc acctaccgcc gcctgctgga     1320

gggcgaggac gcccacctct cctcctccca gttctcctct ggatcgcagt catccagaga     1380

tgtgacctcc tccagccgcc aaatccgcac caaggtcatg gatgtgcacg atggcaaggt     1440

ggtgtccacc cacgagcagg tccttcgcac caagaactga ggctgcccag ccccgctcag     1500

gcctaggagg ccccccgtgt ggacacagat cccactggaa gatcccctct cctgcccaag     1560

cacttcacag ctggaccctg cttcaccctc accccctcct ggcaatcaat acagcttcat     1620

tatctgagtt gcataa                                                     1636


<210>  13
<211>  511
<212>  PRT
<213>  Homo sapiens

<400>  13

Ser Leu Thr Ser Val Pro Phe Ala Arg Ala Gln Asn Gln Lys Arg Lys 
1               5                   10                  15      


Pro Thr Pro Lys Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu 
            20                  25                  30          


Leu Ile Phe Asn Val Ser Ser Lys Gly Ala Val Ser Lys Glu Ile Thr 
        35                  40                  45              


Asn Ala Leu Glu Thr Trp Gly Ala Leu Gly Gln Asp Ile Asn Leu Asp 
    50                  55                  60                  


Ile Pro Ser Phe Gln Met Ser Asp Asp Ile Asp Asp Ile Lys Trp Glu 
65                  70                  75                  80  


Lys Thr Ser Asp Lys Lys Lys Ile Ala Gln Phe Arg Lys Glu Lys Glu 
                85                  90                  95      


Thr Phe Lys Glu Lys Asp Thr Tyr Lys Leu Phe Lys Asn Gly Thr Leu 
            100                 105                 110         


Lys Ile Lys His Leu Lys Thr Asp Asp Gln Asp Ile Tyr Lys Val Ser 
        115                 120                 125             


Ile Tyr Asp Thr Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Asp Leu 
    130                 135                 140                 


Lys Ile Gln Glu Arg Val Ser Lys Pro Lys Ile Ser Trp Thr Cys Ile 
145                 150                 155                 160 


Asn Thr Thr Leu Thr Cys Glu Val Met Asn Gly Thr Asp Pro Glu Leu 
                165                 170                 175     


Asn Leu Tyr Gln Asp Gly Lys His Leu Lys Leu Ser Gln Arg Val Ile 
            180                 185                 190         


Thr His Lys Trp Thr Thr Ser Leu Ser Ala Lys Phe Lys Cys Thr Ala 
        195                 200                 205             


Gly Asn Lys Val Ser Lys Glu Ser Ser Val Glu Pro Val Ser Cys Pro 
    210                 215                 220                 


Glu Lys Gly Leu Asp Ile Tyr Leu Ile Ile Gly Ile Cys Gly Gly Gly 
225                 230                 235                 240 


Ser Leu Leu Met Val Phe Val Ala Leu Leu Val Phe Tyr Ile Thr Lys 
                245                 250                 255     


Arg Lys Lys Gln Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr Arg 
            260                 265                 270         


Ala His Arg Val Ala Thr Glu Glu Arg Gly Arg Lys Pro His Gln Ile 
        275                 280                 285             


Pro Ala Ser Thr Pro Gln Asn Pro Ala Thr Ser Gln His Pro Pro Pro 
    290                 295                 300                 


Pro Pro Gly His Arg Ser Gln Ala Pro Ser His Arg Pro Pro Pro Pro 
305                 310                 315                 320 


Gly His Arg Val Gln His Gln Pro Gln Lys Arg Pro Pro Ala Pro Ser 
                325                 330                 335     


Gly Thr Gln Val His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro Arg 
            340                 345                 350         


Val Gln Pro Lys Pro Pro His Gly Ala Ala Glu Asn Ser Leu Ser Pro 
        355                 360                 365             


Ser Ser Asn Lys Arg Lys Leu Ser Phe Ser Ile Lys Ser Thr Val Asp 
    370                 375                 380                 


Phe Cys Pro Pro Asp Val His Ile Arg Thr Ser Met Arg Cys Phe Leu 
385                 390                 395                 400 


Cys Ala Glu His Cys His Leu Leu Arg Leu Trp Ala Thr Ala Thr Ser 
                405                 410                 415     


Ala Ser Ser Asn Ser Ala Met Trp Ser Thr Ser Gly Val Phe Gly Leu 
            420                 425                 430         


Leu Arg Glu Leu His His Thr Ser Lys Glu Lys Gln Tyr Lys Cys Asp 
        435                 440                 445             


Cys Lys Asn Gly Arg Gly Pro Ser Thr Glu Ile Leu Glu Ile Ser Cys 
    450                 455                 460                 


Pro Leu Ser Gly His Val Met Arg Ile Lys Leu Val Cys Leu Gly Leu 
465                 470                 475                 480 


Thr Thr Ser Ser Leu Ser Ala Glu Thr Leu Glu Phe Leu Met Cys Pro 
                485                 490                 495     


Gly Gly His Leu Pro Thr Ile Leu Val Lys Val Lys Lys Leu Leu 
            500                 505                 510     


<210>  14
<211>  1565
<212>  DNA
<213>  Homo sapiens

<400>  14
agtctcactt cagttccttt tgcatgaaga gctcagaatc aaaagaggaa accaacccct       60

aagatgagct ttccatgtaa atttgtagcc agcttccttc tgattttcaa tgtttcttcc      120

aaaggtgcag tctccaaaga gattacgaat gccttggaaa cctggggtgc cttgggtcag      180

gacatcaact tggacattcc tagttttcaa atgagtgatg atattgacga tataaaatgg      240

gaaaaaactt cagacaagaa aaagattgca caattcagaa aagagaaaga gactttcaag      300

gaaaaagata catataagct atttaaaaat ggaactctga aaattaagca tctgaagacc      360

gatgatcagg atatctacaa ggtatcaata tatgatacaa aaggaaaaaa tgtgttggaa      420

aaaatatttg atttgaagat tcaagagagg gtctcaaaac caaagatctc ctggacttgt      480

atcaacacaa ccctgacctg tgaggtaatg aatggaactg accccgaatt aaacctgtat      540

caagatggga aacatctaaa actttctcag agggtcatca cacacaagtg gaccaccagc      600

ctgagtgcaa aattcaagtg cacagcaggg aacaaagtca gcaaggaatc cagtgtcgag      660

cctgtcagct gtccagagaa aggtctggac atctatctca tcattggcat atgtggagga      720

ggcagcctct tgatggtctt tgtggcactg ctcgttttct atatcaccaa aaggaaaaaa      780

cagaggagtc ggagaaatga tgaggagctg gagacaagag cccacagagt agctactgaa      840

gaaaggggcc ggaagcccca ccaaattcca gcttcaaccc ctcagaatcc agcaacttcc      900

caacatcctc ctccaccacc tggtcatcgt tcccaggcac ctagtcatcg tcccccgcct      960

cctggacacc gtgttcagca ccagcctcag aagaggcctc ctgctccgtc gggcacacaa     1020

gttcaccagc agaaaggccc gcccctcccc agacctcgag ttcagccaaa acctccccat     1080

ggggcagcag aaaactcatt gtccccttcc tctaattaaa aaagatagaa actgtctttt     1140

tcaataaaaa gcactgtgga tttctgccct cctgatgtgc atatccgtac ttccatgagg     1200

tgttttctgt gtgcagaaca ttgtcacctc ctgaggctgt gggccacagc cacctctgca     1260

tcttcgaact cagccatgtg gtcaacatct ggagtttttg gtctcctcag agagctccat     1320

cacaccagta aggagaagca atataagtgt gattgcaaga atggtagagg accgagcaca     1380

gaaatcttag agatttcttg tcccctctca ggtcatgtgt agatgcgata aatcaagtga     1440

ttggtgtgcc tgggtctcac tacaagcagc ctatctgctt aagagactct ggagtttctt     1500

atgtgccctg gtggacactt gcccaccatc ctgtgagtaa aagtgaaata aaagctttga     1560

ctaga                                                                 1565


<210>  15
<211>  1060
<212>  PRT
<213>  Homo sapiens

<400>  15

Val Phe Glu Ala Pro Lys Asn Ile Ser Cys Cys Trp Glu Tyr Glu Asp 
1               5                   10                  15      


Ile Asp Val Glu Cys Val Leu Val Cys Trp Arg Cys Ile Asn Asp Ser 
            20                  25                  30          


Thr Cys Gln Thr Thr Arg Gly Ser Leu Phe His Asp Phe Arg Ala Val 
        35                  40                  45              


Val Ser Phe Phe Pro Leu Gly Arg Glu Ala Asn Lys Leu Ser His Arg 
    50                  55                  60                  


Leu Trp Arg Gly Thr Thr Leu Gln Tyr Trp Leu Tyr Ile Cys Arg Ser 
65                  70                  75                  80  


Ser Leu Lys Asp Arg Tyr Leu Ser Pro Gly Cys Glu Leu Thr Gln Gln 
                85                  90                  95      


Ser Gly Arg Gly Pro Gln Tyr His Ser Ala Cys Tyr Leu Lys Arg Gly 
            100                 105                 110         


Asn Gly Gln Ser Lys Ala Gln Gln Ser Asp Cys Ser Asn Thr Phe Lys 
        115                 120                 125             


Ile Gly Ala Asp Cys Ser Trp Val Cys Lys Pro Asn Phe Ile Cys Val 
    130                 135                 140                 


Trp Ile Lys Lys Ala Asn Val His Gly Gly Glu Asn Glu Leu Asn Phe 
145                 150                 155                 160 


Pro Cys Tyr Gln His Trp Gln Tyr Gly Ser Gln Cys Cys Gly Asn Asn 
                165                 170                 175     


Gly Thr Lys Phe Phe Pro Pro Asn Ala Val Gln His Phe Gly Cys Pro 
            180                 185                 190         


Asp Tyr Tyr Trp Arg Met Pro Leu Lys Leu Ser Lys Ser Val Cys Ile 
        195                 200                 205             


Arg Ala Ala Lys Glu Cys Asn Ala Asp Leu Glu Arg His Ser Pro Val 
    210                 215                 220                 


Leu Val Gln Asp Glu Ala Ile Val Leu His Lys Ser Ser Thr Leu Phe 
225                 230                 235                 240 


Lys Phe Leu Val Phe Trp Glu Asn Gly Lys Trp Lys Arg Ser Gln Cys 
                245                 250                 255     


Ser Tyr Pro Thr Gly Arg Pro Ala Ile His Phe Arg Asn Gly Asp Phe 
            260                 265                 270         


Ser Thr Gln Val Asn Lys Ser Asn Arg Phe Ser Arg Ala Lys Ser Lys 
        275                 280                 285             


Ser Asn Thr Lys Gln Gly Glu Cys Cys Ala Cys Ser Thr Gly Arg Thr 
    290                 295                 300                 


Thr Ser Ser Lys Thr Gln Thr Leu Phe His His Ser Asp Tyr Phe Lys 
305                 310                 315                 320 


Leu Ala Thr Trp Thr Tyr Cys Thr Ser Val Asp Leu Ile Cys Tyr Val 
                325                 330                 335     


Glu Gly Trp Leu Leu Lys Thr Ile Gln Ile Tyr Pro Thr Arg Arg Lys 
            340                 345                 350         


Gln Lys Arg Gln Leu Glu Leu Tyr Gln Gln Lys Gln Leu Arg Thr Ser 
        355                 360                 365             


Phe Lys Leu Arg Glu Trp Lys Thr Asp Ser Gly Cys Ser Lys Glu Ile 
    370                 375                 380                 


Lys Thr Leu Phe Thr Arg Lys Asn Glu Phe Cys Leu Asp Phe Phe Tyr 
385                 390                 395                 400 


Ser Ser Cys Asp Ile Leu Cys Leu His Ala Arg Gly Lys Ser Gln Gln 
                405                 410                 415     


Leu Leu Phe Glu Ile Glu Glu Leu Gln Arg Tyr Ser Gln Arg Ser Leu 
            420                 425                 430         


Ser Phe Met Gly Arg Glu Thr Leu Lys His Ser Ile Tyr Ser Arg Lys 
        435                 440                 445             


Val Ser Pro Arg Tyr Leu Glu Met Lys Val Leu Ser Ile Ile Leu Glu 
    450                 455                 460                 


Lys Ser Thr Asn Thr Thr Tyr His Met Cys Leu Pro Gln Asn Glu Pro 
465                 470                 475                 480 


His Trp Val Gly Arg Gly Ser Phe Gln Ile His Leu Tyr Leu Phe Lys 
                485                 490                 495     


Ile Cys Ser Leu Lys Ile Phe Phe Arg Glu Leu Phe Pro Asn Phe Leu 
            500                 505                 510         


Thr Ser Gly Pro Leu Ser Leu Ser Pro Leu Phe Ile Ile His Phe Leu 
        515                 520                 525             


Arg Ala Val Phe Gln Gln Pro Phe Phe Phe Ser Arg Leu Ile Leu Tyr 
    530                 535                 540                 


Tyr Arg Pro Asn Trp Gln Thr Ser Asp Thr Cys Thr Leu Val Ala Asn 
545                 550                 555                 560 


Asp Phe Trp Ile Ile Ile Phe Leu Leu Trp Ile Ser Pro Ser Phe Phe 
                565                 570                 575     


Leu Tyr Ile Tyr Met Cys Phe Tyr Val Gly Ile Tyr Leu Pro Phe Phe 
            580                 585                 590         


Leu Ser Ile Leu Pro Ile Thr His Leu Tyr Gln Ala Tyr Pro Gly Val 
        595                 600                 605             


Ile Phe Lys Ser Phe Val Ile Phe Asn Lys Arg Leu Val Leu His Phe 
    610                 615                 620                 


Thr Tyr Met Leu Ile Lys Ile Gln Lys Pro Tyr Leu Thr Asn Asn Phe 
625                 630                 635                 640 


Lys Ile Lys Ala Val Gln Arg Leu Gly Gly Leu Tyr Phe Ile Cys Ile 
                645                 650                 655     


Met Tyr Tyr Val Lys Tyr Leu Ser His Asn Tyr Phe Leu Gly Cys Asn 
            660                 665                 670         


Ser Leu Leu Pro Phe Thr Ser Ile Ser Val Thr Leu His Gly Asn Glu 
        675                 680                 685             


Glu Thr Lys Phe Ile Asn Leu Asn Ser Ile Leu Lys Asp Thr Asp Ser 
    690                 695                 700                 


Ile Cys Ile Gln Ile Met Arg Arg Gln Gln Asn Phe His Glu Met Asn 
705                 710                 715                 720 


Ile Phe Ile Val Cys Ser Tyr Tyr Met Arg Phe Tyr Phe Lys Leu Ser 
                725                 730                 735     


Gly Phe Lys Ile Ser Leu Asn Thr Ile Ile Phe Val Ile Phe Ile Leu 
            740                 745                 750         


Cys Leu Ser Arg Leu Gln Asn Ile Ile Leu Ser Asp Ser Val Phe Ile 
        755                 760                 765             


Arg Glu Leu Trp Pro Asn Phe Glu His Leu Leu Gly Val Ile Lys Leu 
    770                 775                 780                 


Glu Gly Asn Val Glu Lys Gln Phe Trp Glu Arg Phe Leu Tyr Met Lys 
785                 790                 795                 800 


Ser Leu Pro Leu Ala Ser His Pro Asn Lys Leu Ser Val His Arg Pro 
                805                 810                 815     


Ala Val Met Val Arg Asn Val Leu Arg Phe Ala Lys Ala Phe Glu Asn 
            820                 825                 830         


Val Ser Thr Lys Pro Pro Glu Pro Arg Val Cys Ile His Arg Asn Lys 
        835                 840                 845             


Leu Tyr Asp Ile Tyr Val Phe Leu Lys Asn Phe Val Ser Leu Lys Gly 
    850                 855                 860                 


Ser Phe Phe Gln Glu Asn Ile Asp His Arg Lys Ile Lys Pro Arg Phe 
865                 870                 875                 880 


Arg Thr Val Phe Ser Arg Ile Val Ser Lys Glu Ile Tyr Ile Trp Phe 
                885                 890                 895     


Phe Pro Thr Gln Asn Tyr Ser Glu Thr Thr Ile Tyr Phe Arg Leu Phe 
            900                 905                 910         


Glu His Ser Glu Ser Arg Val Leu Trp Leu Ser Asn Thr Gly Leu Ser 
        915                 920                 925             


Asp Thr Arg Gly Thr Gln Leu His Ile Gly Leu Asp Phe Ala Gln Phe 
    930                 935                 940                 


Lys Ile Val Phe Val Ile Asn Leu Leu Cys Tyr Leu Tyr His Glu Phe 
945                 950                 955                 960 


Asn Pro Thr Thr Leu Arg Arg Gln Gly Trp Val Ile Leu Phe Trp Gln 
                965                 970                 975     


Val Gly Tyr Ile Thr Met Phe Asn Leu Thr Ala Leu Asp Gly Ala Val 
            980                 985                 990         


Asn Gln Gly Arg Leu Met Lys Ser  Val Leu Tyr Leu Gln  Asn Ile Gly 
        995                 1000                 1005             


Asn Leu  Thr Leu Met Ser Ser  Asn Pro Glu Lys Lys  Asn Pro Asn 
    1010                 1015                 1020             


Tyr Phe  Arg Ile Ile Val Lys  Tyr Cys Ile Met Met  Val Ala Lys 
    1025                 1030                 1035             


Phe Phe  Val Cys Pro Ile Asn  Thr Leu Lys Lys Glu  Phe Glu Leu 
    1040                 1045                 1050             


Ile Phe  Lys Lys Lys Lys Lys  
    1055                 1060 


<210>  16
<211>  3459
<212>  DNA
<213>  Homo sapiens

<400>  16
gtttttgaag ccccatgaaa ataaaacata tcttgctgtt gggagtatga agacattgat       60

gttgaatgtg tccttgttta atgctggaga tgatgcatat gaaacgactc tacatgtcaa      120

actacccgtg ggtctttatt tcattaagat tttagagctg ttgtttcatt tttcccatta      180

ggaagagaag caaataaact gtgaagtcac agataactct ggcgtggtac aacttgactg      240

cagtattggc tatatatatg tagatcatct ctcaaggata gatattagct ttctcctgga      300

tgtgagctca ctcagcagag cggaagagga cctcagtatc acagtgcatg ctacctgtga      360

aaatgaagag gaaatggaca atctaaagca cagcagagtg actgtagcaa tacctttaaa      420

atatgaggtt aagctgactg ttcatgggtt tgtaaaccca acttcatttg tgtatggatc      480

aaatgatgaa aatgagcctg aaacgtgcat ggtggagaaa atgaacttaa ctttccatgt      540

tatcaacact ggcaatagta tggctcccaa tgttagtgtg gaaataatgg taccaaattc      600

ttttagcccc caaactgata agctgttcaa cattttggat gtccagacta ctactggaga      660

atgccacttt gaaaattatc aaagagtgtg tgcattagag cagcaaaaga gtgcaatgca      720

gaccttgaaa ggcatagtcc agttcttgtc caagactgat aagaggctat tgtactgcat      780

aaaagctgat ccacattgtt taaatttctt gtgtaatttt gggaaaatgg aaagtggaaa      840

agaagccagt gttcatatcc aactggaagg ccggccatcc attttagaaa tggatgagac      900

ttcagcactc aagtttgaaa taagagcaac aggttttcca gagccaaatc caagagtaat      960

tgaactaaac aaggatgaga atgttgcgca tgttctactg gaaggactac atcatcaaag     1020

acccaaacgt tatttcacca tagtgattat ttcaagtagc ttgctacttg gacttattgt     1080

acttctgttg atctcatatg ttatgtggaa ggctggcttc tttaaaagac aatacaaatc     1140

tatcctacaa gaagaaaaca gaagagacag ttggagttat atcaacagta aaagcaatga     1200

tgattaagga cttctttcaa attgagagaa tggaaaacag actcaggttg tagtaaagaa     1260

atttaaaaga cactgtttac aagaaaaaat gaattttgtt tggacttctt ttactcatga     1320

tcttgtgaca tattatgtct tcatgcaagg ggaaaatctc agcaatgatt actctttgag     1380

atagaagaac tgcaaaggta ataatacagc caaagataat ctctcagctt ttaaatgggt     1440

agagaaacac taaagcattc aatttattca agaaaagtaa gcccttgaag atatcttgaa     1500

atgaaagtat aactgagtta aattatactg gagaagtctt agacttgaaa tactacttac     1560

catatgtgct tgcctcagta aaatgaaccc cactgggtgg gcagaggttc atttcaaata     1620

catctttgat acttgttcaa aatatgttct ttaaaaatat aattttttag agagctgttc     1680

ccaaattttc taacgagtgg accattatca ctttaaagcc ctttatttat aatacatttc     1740

ctacgggctg tgttccaaca accatttttt ttcagcagac tatgaatatt atagtattat     1800

aggccaaact ggcaaacttc agactgaaca tgtacactgg tttgagctta gtgaaatgac     1860

ttctggataa ttattttttt ataattatgg atttcaccat ctttctttct gtatatatac     1920

atgtgttttt atgtaggtat atatttacca ttcttcctat ctattcttcc tataacacac     1980

ctttatcaag catacccagg agtaatcttc aaatcttttg ttatattctg aaacaaaaga     2040

ttgtgagtgt tgcactttac ctgatacatg ctgatttaga aaatacagaa accatacctc     2100

actaataact ttaaaatcaa agctgtgcaa agactagggg gcctatactt catatgtatt     2160

atgtactatg taaaatattg actatcacac aactatttcc ttggatgtaa ttctttgtta     2220

ccctttacaa gtataagtgt taccttacat ggaaacgaag aaacaaaatt cataaattta     2280

aattcataaa tttagctgaa agatactgat tcaatttgta tacagtgaat ataaatgaga     2340

cgacagcaaa attttcatga aatgtaaaat atttttatag tttgttcata ctatatgagg     2400

ttctatttta aatgactttc tggattttaa aaaatttctt taaatacaat catttttgta     2460

atatttattt tatgcttatg atctagataa ttgcagaata tcattttatc tgactctgtc     2520

ttcataagag agctgtggcc gaattttgaa catctgttat agggagtgat caaattagaa     2580

ggcaatgtgg aaaaacaatt ctgggaaaga tttctttata tgaagtccct gccactagcc     2640

agccatccta attgatgaaa gttatctgtt cacaggcctg cagtgatggt gaggaatgtt     2700

ctgagatttg cgaaggcatt tgagtagtga aatgtaagca caaaacctcc tgaacccaga     2760

gtgtgtatac acaggaataa actttatgac atttatgtat ttttaaaaaa ctttgtatcg     2820

ttataaaaag gctagtcatt ctttcaggag aacatctagg atcatagatg aaaaatcaag     2880

ccccgattta gaactgtctt ctccaggatt gtctctaagg aaatttacat ttggttcttt     2940

cctactcaga actactcaga aacaactata tatttcaggt tatttgagca cagtgaaagc     3000

agagtactat ggttgtccaa cacaggcctc tcagatacaa ggggaacaca attacatatt     3060

gggctagatt ttgcccagtt caaaatagta tttgttatca acttactttg ttacttgtat     3120

catgaatttt aaaaccctac cactttaaga agacagggat gggttattct tttttggcag     3180

gtaggctata taactatgtg attttgaaat ttaactgctc tggattaggg agcagtgaat     3240

caaggcagac ttatgaaatc tgtattatat ttgtaacaga atataggaaa tttaacataa     3300

ttgatgagct caaatcctga aaaatgaaag aatccaaatt atttcagaat tatctaggtt     3360

aaatattgat gtattatgat ggttgcaaag ttttttgtgt gtccaataaa cacattgtaa     3420

aaaaaagaat ttgaattgat atttaaaaaa aaaaaaaaa                            3459


<210>  17
<211>  1691
<212>  PRT
<213>  Homo sapiens

<400>  17

Ile Ile Phe Leu Phe His Pro Val Val Ala Ser Lys Ser His Gly Pro 
1               5                   10                  15      


Pro Asp Ala Ala Pro Gly Ala Thr Gly Pro Ser Ser Ala Gly Arg Met 
            20                  25                  30          


Lys Asp Ser Cys Ile Thr Val Met Ala Met Ala Leu Leu Ser Gly Phe 
        35                  40                  45              


Phe Phe Phe Ala Pro Ala Ser Ser Tyr Asn Leu Asp Val Arg Gly Ala 
    50                  55                  60                  


Arg Ser Phe Ser Pro Pro Arg Ala Gly Arg His Phe Gly Tyr Arg Val 
65                  70                  75                  80  


Leu Gln Val Gly Asn Gly Val Ile Val Gly Ala Pro Gly Glu Gly Asn 
                85                  90                  95      


Ser Thr Gly Ser Leu Tyr Gln Cys Gln Ser Gly Thr Gly His Cys Leu 
            100                 105                 110         


Pro Val Thr Leu Arg Gly Ser Asn Tyr Thr Ser Lys Tyr Leu Gly Met 
        115                 120                 125             


Thr Leu Ala Thr Asp Pro Thr Asp Gly Ser Ile Leu Ala Cys Asp Pro 
    130                 135                 140                 


Gly Leu Ser Arg Thr Cys Asp Gln Asn Thr Tyr Leu Ser Gly Leu Cys 
145                 150                 155                 160 


Tyr Leu Phe Arg Gln Asn Leu Gln Gly Pro Met Leu Gln Gly Arg Pro 
                165                 170                 175     


Gly Phe Gln Glu Cys Ile Lys Gly Asn Val Asp Leu Val Phe Leu Phe 
            180                 185                 190         


Asp Gly Ser Met Ser Leu Gln Pro Asp Glu Phe Gln Lys Ile Leu Asp 
        195                 200                 205             


Phe Met Lys Asp Val Met Lys Lys Leu Ser Asn Thr Ser Tyr Gln Phe 
    210                 215                 220                 


Ala Ala Val Gln Phe Ser Thr Ser Tyr Lys Thr Glu Phe Asp Phe Ser 
225                 230                 235                 240 


Asp Tyr Val Lys Arg Lys Asp Pro Asp Ala Leu Leu Lys His Val Lys 
                245                 250                 255     


His Met Leu Leu Leu Thr Asn Thr Phe Gly Ala Ile Asn Tyr Val Ala 
            260                 265                 270         


Thr Glu Val Phe Arg Glu Glu Leu Gly Ala Arg Pro Asp Ala Thr Lys 
        275                 280                 285             


Val Leu Ile Ile Ile Thr Asp Gly Glu Ala Thr Asp Ser Gly Asn Ile 
    290                 295                 300                 


Asp Ala Ala Lys Asp Ile Ile Arg Tyr Ile Ile Gly Ile Gly Lys His 
305                 310                 315                 320 


Phe Gln Thr Lys Glu Ser Gln Glu Thr Leu His Lys Phe Ala Ser Lys 
                325                 330                 335     


Pro Ala Ser Glu Phe Val Lys Ile Leu Asp Thr Phe Glu Lys Leu Lys 
            340                 345                 350         


Asp Leu Phe Thr Glu Leu Gln Lys Lys Ile Tyr Val Ile Glu Gly Thr 
        355                 360                 365             


Ser Lys Gln Asp Leu Thr Ser Phe Asn Met Glu Leu Ser Ser Ser Gly 
    370                 375                 380                 


Ile Ser Ala Asp Leu Ser Arg Gly His Ala Val Val Gly Ala Val Gly 
385                 390                 395                 400 


Ala Lys Asp Trp Ala Gly Gly Phe Leu Asp Leu Lys Ala Asp Leu Gln 
                405                 410                 415     


Asp Asp Thr Phe Ile Gly Asn Glu Pro Leu Thr Pro Glu Val Arg Ala 
            420                 425                 430         


Gly Tyr Leu Gly Tyr Thr Val Thr Trp Leu Pro Ser Arg Gln Lys Thr 
        435                 440                 445             


Ser Leu Leu Ala Ser Gly Ala Pro Arg Tyr Gln His Met Gly Arg Val 
    450                 455                 460                 


Leu Leu Phe Gln Glu Pro Gln Gly Gly Gly His Trp Ser Gln Val Gln 
465                 470                 475                 480 


Thr Ile His Gly Thr Gln Ile Gly Ser Tyr Phe Gly Gly Glu Leu Cys 
                485                 490                 495     


Gly Val Asp Val Asp Gln Asp Gly Glu Thr Glu Leu Leu Leu Ile Gly 
            500                 505                 510         


Ala Pro Leu Phe Tyr Gly Glu Gln Arg Gly Gly Arg Val Phe Ile Tyr 
        515                 520                 525             


Gln Arg Arg Gln Leu Gly Phe Glu Glu Val Ser Glu Leu Gln Gly Asp 
    530                 535                 540                 


Pro Gly Tyr Pro Leu Gly Arg Phe Gly Glu Ala Ile Thr Ala Leu Thr 
545                 550                 555                 560 


Asp Ile Asn Gly Asp Gly Leu Val Asp Val Ala Val Gly Ala Pro Leu 
                565                 570                 575     


Glu Glu Gln Gly Ala Val Tyr Ile Phe Asn Gly Arg His Gly Gly Leu 
            580                 585                 590         


Ser Pro Gln Pro Ser Gln Arg Ile Glu Gly Thr Gln Val Leu Ser Gly 
        595                 600                 605             


Ile Gln Trp Phe Gly Arg Ser Ile His Gly Val Lys Asp Leu Glu Gly 
    610                 615                 620                 


Asp Gly Leu Ala Asp Val Ala Val Gly Ala Glu Ser Gln Met Ile Val 
625                 630                 635                 640 


Leu Ser Ser Arg Pro Val Val Asp Met Val Thr Leu Met Ser Phe Ser 
                645                 650                 655     


Pro Ala Glu Ile Pro Val His Glu Val Glu Cys Ser Tyr Ser Thr Ser 
            660                 665                 670         


Asn Lys Met Lys Glu Gly Val Asn Ile Thr Ile Cys Phe Gln Ile Lys 
        675                 680                 685             


Ser Leu Ile Pro Gln Phe Gln Gly Arg Leu Val Ala Asn Leu Thr Tyr 
    690                 695                 700                 


Thr Leu Gln Leu Asp Gly His Arg Thr Arg Arg Arg Gly Leu Phe Pro 
705                 710                 715                 720 


Gly Gly Arg His Glu Leu Arg Arg Asn Ile Ala Val Thr Thr Ser Met 
                725                 730                 735     


Ser Cys Thr Asp Phe Ser Phe His Phe Pro Val Cys Val Gln Asp Leu 
            740                 745                 750         


Ile Ser Pro Ile Asn Val Ser Leu Asn Phe Ser Leu Trp Glu Glu Glu 
        755                 760                 765             


Gly Thr Pro Arg Asp Gln Arg Ala Gln Gly Lys Asp Ile Pro Pro Ile 
    770                 775                 780                 


Leu Arg Pro Ser Leu His Ser Glu Thr Trp Glu Ile Pro Phe Glu Lys 
785                 790                 795                 800 


Asn Cys Gly Glu Asp Lys Lys Cys Glu Ala Asn Leu Arg Val Ser Phe 
                805                 810                 815     


Ser Pro Ala Arg Ser Arg Ala Leu Arg Leu Thr Ala Phe Ala Ser Leu 
            820                 825                 830         


Ser Val Glu Leu Ser Leu Ser Asn Leu Glu Glu Asp Ala Tyr Trp Val 
        835                 840                 845             


Gln Leu Asp Leu His Phe Pro Pro Gly Leu Ser Phe Arg Lys Val Glu 
    850                 855                 860                 


Met Leu Lys Pro His Ser Gln Ile Pro Val Ser Cys Glu Glu Leu Pro 
865                 870                 875                 880 


Glu Glu Ser Arg Leu Leu Ser Arg Ala Leu Ser Cys Asn Val Ser Ser 
                885                 890                 895     


Pro Ile Phe Lys Ala Gly His Ser Val Ala Leu Gln Met Met Phe Asn 
            900                 905                 910         


Thr Leu Val Asn Ser Ser Trp Gly Asp Ser Val Glu Leu His Ala Asn 
        915                 920                 925             


Val Thr Cys Asn Asn Glu Asp Ser Asp Leu Leu Glu Asp Asn Ser Ala 
    930                 935                 940                 


Thr Thr Ile Ile Pro Ile Leu Tyr Pro Ile Asn Ile Leu Ile Gln Asp 
945                 950                 955                 960 


Gln Glu Asp Ser Thr Leu Tyr Val Ser Phe Thr Pro Lys Gly Pro Lys 
                965                 970                 975     


Ile His Gln Val Lys His Met Tyr Gln Val Arg Ile Gln Pro Ser Ile 
            980                 985                 990         


His Asp His Asn Ile Pro Thr Leu  Glu Ala Val Val Gly  Val Pro Gln 
        995                 1000                 1005             


Pro Pro  Ser Glu Gly Pro Ile  Thr His Gln Trp Ser  Val Gln Met 
    1010                 1015                 1020             


Glu Pro  Pro Val Pro Cys His  Tyr Glu Asp Leu Glu  Arg Leu Pro 
    1025                 1030                 1035             


Asp Ala  Ala Glu Pro Cys Leu  Pro Gly Ala Leu Phe  Arg Cys Pro 
    1040                 1045                 1050             


Val Val  Phe Arg Gln Glu Ile  Leu Val Gln Val Ile  Gly Thr Leu 
    1055                 1060                 1065             


Glu Leu  Val Gly Glu Ile Glu  Ala Ser Ser Met Phe  Ser Leu Cys 
    1070                 1075                 1080             


Ser Ser  Leu Ser Ile Ser Phe  Asn Ser Ser Lys His  Phe His Leu 
    1085                 1090                 1095             


Tyr Gly  Ser Asn Ala Ser Leu  Ala Gln Val Val Met  Lys Val Asp 
    1100                 1105                 1110             


Val Val  Tyr Glu Lys Gln Met  Leu Tyr Leu Tyr Val  Leu Ser Gly 
    1115                 1120                 1125             


Ile Gly  Gly Leu Leu Leu Leu  Leu Leu Ile Phe Ile  Val Leu Tyr 
    1130                 1135                 1140             


Lys Val  Gly Phe Phe Lys Arg  Asn Leu Lys Glu Lys  Met Glu Ala 
    1145                 1150                 1155             


Gly Arg  Gly Val Pro Asn Gly  Ile Pro Ala Glu Asp  Ser Glu Gln 
    1160                 1165                 1170             


Leu Ala  Ser Gly Gln Glu Ala  Gly Asp Pro Gly Cys  Leu Lys Pro 
    1175                 1180                 1185             


Leu His  Glu Lys Asp Ser Glu  Ser Gly Gly Gly Lys  Asp Val Gln 
    1190                 1195                 1200             


Ala Cys  Glu Val Gln Ser Ala  Gln Asn Trp Thr Gln  Asp Ala Gln 
    1205                 1210                 1215             


Gly His  Ser Ala Ser Ala Cys  Ile Leu Pro Cys Ala  Leu Gly Arg 
    1220                 1225                 1230             


Val Thr  Ala Ser Pro Trp Pro  Ser Val Ser Leu Ser  Arg Thr Trp 
    1235                 1240                 1245             


Asn Ser  Phe Leu Pro Val Ser  Phe Ala Gly Ser Gly  Arg Pro Ala 
    1250                 1255                 1260             


Glu Gly  Pro Ala Lys Arg Ala  Ala Lys Val Arg Ala  Cys His Tyr 
    1265                 1270                 1275             


Gln Thr  Val His Gln Pro Leu  Leu Val Ser Phe Leu  Gly Arg Glu 
    1280                 1285                 1290             


Cys Leu  Ile Met Trp Arg Asn  Cys Ser Leu Arg Thr  Gly Cys Ser 
    1295                 1300                 1305             


Gly Pro  His Pro Cys Pro Gly  Met Ser Thr Asp Ala  Ser Thr Pro 
    1310                 1315                 1320             


Gln Asn  Leu Ser Leu His Thr  Pro Leu His Trp Ser  Pro Val Ser 
    1325                 1330                 1335             


Ser Ala  Gly Arg Lys Gln Met  Pro Val Ser Leu Arg  Asp Cys Gly 
    1340                 1345                 1350             


Thr Arg  Leu Val Leu Gly Gln  Arg Pro Asn Ser Leu  Ala Cys Leu 
    1355                 1360                 1365             


Pro Ala  Pro Cys Lys Met Arg  Pro Ser Trp Pro Ser  Pro Ala Ser 
    1370                 1375                 1380             


Ser Arg  Ala Val Met Pro Pro  Cys Ser Ser Gly Asp  Thr Ser Leu 
    1385                 1390                 1395             


Ser Pro  Arg Pro Gly Ser Phe  Leu Ser Ser Cys Ile  His Pro Asp 
    1400                 1405                 1410             


Ser Ser  Leu Cys Leu Asn Leu  Pro Ser Arg His Pro  Ser Phe Leu 
    1415                 1420                 1425             


Asp Gln  Gln Ile Pro Ala His  Val Thr Leu Gly Trp  Val Leu Thr 
    1430                 1435                 1440             


Ser Phe  Thr Leu Pro Pro Ala  Cys Thr Thr Pro Ser  Lys His Thr 
    1445                 1450                 1455             


Ser Cys  Phe Phe Ile Arg Gln  Pro Gly Cys Phe Phe  Pro Val Leu 
    1460                 1465                 1470             


Thr Tyr  Leu Ala Ala Ile Ser  Gln Thr Val Arg Val  Lys Ala Ile 
    1475                 1480                 1485             


Leu Val  Leu Phe Thr Leu Gly  Cys Leu Met Ile Cys  Gln Gly Val 
    1490                 1495                 1500             


Gly His  Leu Val Gly Ala His  Asn Phe Thr Glu Leu  Met Thr Glu 
    1505                 1510                 1515             


Pro Val  Gly Arg Tyr Arg Lys  Arg Gly Ala Gly Leu  Gly Ala Val 
    1520                 1525                 1530             


Val His  Ala Cys Asn Pro Ser  Thr Leu Gly Gly Gln  Gly Gly Trp 
    1535                 1540                 1545             


Ile Thr  Gly Gln Glu Leu Glu  Ala Ser Leu Ala Lys  Pro His Leu 
    1550                 1555                 1560             


Tyr Lys  Tyr Lys Ile Gln Ala  Trp Trp His Thr Pro  Val Val Pro 
    1565                 1570                 1575             


Ala Thr  Gln Glu Val Glu Val  Gly Glu Leu Leu Glu  Pro Gly Arg 
    1580                 1585                 1590             


Trp Arg  Leu Gln Ala Lys Ile  Ala Pro Leu His Ser  Ser Leu Gly 
    1595                 1600                 1605             


Asn Thr  Ala Arg Leu Arg Leu  Lys Glu Lys Ile Lys  Ile Lys Ser 
    1610                 1615                 1620             


Gly His  Gly Pro Val Thr Ser  Pro Pro Leu Glu Ala  Val Phe Ser 
    1625                 1630                 1635             


Gly Ser  Ala Leu Pro Leu His  Thr Leu Ser Gln Asp  Pro Ser Arg 
    1640                 1645                 1650             


Leu Cys  Ser Gly Pro His Arg  Lys Thr Glu Leu Lys  Val Gly Thr 
    1655                 1660                 1665             


Thr Ser  Ala Asn Leu Glu Pro  Gln Cys Gln Ala Gln  Cys Leu His 
    1670                 1675                 1680             


Val Phe  Ile Gln Met Asn Ser  Val 
    1685                 1690     


<210>  18
<211>  5129
<212>  DNA
<213>  Homo sapiens

<400>  18
atcattttcc tctttcaccc tgtctaggtt gccagcaaat cccacgggcc tcctgacgct       60

gcccctgggg ccacaggtcc ctcgagtgct ggaaggatga aggattcctg catcactgtg      120

atggccatgg cgctgctgtc tgggttcttt ttcttcgcgc cggcctcgag ctacaacctg      180

gacgtgcggg gcgcgcggag cttctcccca ccgcgcgccg ggaggcactt tggataccgc      240

gtcctgcagg tcggaaacgg ggtcatcgtg ggagctccag gggaggggaa cagcacagga      300

agcctctatc agtgccagtc gggcacagga cactgcctgc cagtcaccct gagaggttcc      360

aactatacct ccaagtactt gggaatgacc ttggcaacag accccacaga tggaagcatt      420

ttggcctgtg accctgggct gtctcgaacg tgtgaccaga acacctatct gagtggcctg      480

tgttacctct tccgccagaa tctgcagggt cccatgctgc aggggcgccc tggttttcag      540

gaatgtatca agggcaacgt agacctggta tttctgtttg atggttcgat gagcttgcag      600

ccagatgaat ttcagaaaat tctggacttc atgaaggatg tgatgaagaa actcagcaac      660

acttcgtacc agtttgctgc tgttcagttt tccacaagct acaaaacaga atttgatttc      720

tcagattatg ttaaacggaa ggaccctgat gctctgctga agcatgtaaa gcacatgttg      780

ctgttgacca atacctttgg tgccatcaat tatgtcgcga cagaggtgtt ccgggaggag      840

ctgggggccc ggccagatgc caccaaagtg cttatcatca tcacggatgg ggaggccact      900

gacagtggca acatcgatgc ggccaaagac atcatccgct acatcatcgg gattggaaag      960

cattttcaga ccaaggagag tcaggagacc ctccacaaat ttgcatcaaa acccgcgagc     1020

gagtttgtga aaattctgga cacatttgag aagctgaaag atctattcac tgagctgcag     1080

aagaagatct atgtcattga gggcacaagc aaacaggacc tgacttcctt caacatggag     1140

ctgtcctcca gcggcatcag tgctgacctc agcaggggcc atgcagtcgt gggggcagta     1200

ggagccaagg actgggctgg gggctttctt gacctgaagg cagacctgca ggatgacaca     1260

tttattggga atgaaccatt gacaccagaa gtgagagcag gctatttggg ttacaccgtg     1320

acctggctgc cctcccggca aaagacttcg ttgctggcct cgggagcccc tcgataccag     1380

cacatgggcc gagtgctgct gttccaagag ccacagggcg gaggacactg gagccaggtc     1440

cagacaatcc atgggaccca gattggctct tatttcggtg gggagctgtg tggcgtcgac     1500

gtggaccaag atggggagac agagctgctg ctgattggtg ccccactgtt ctatggggag     1560

cagagaggag gccgggtgtt tatctaccag agaagacagt tggggtttga agaagtctca     1620

gagctgcagg gggaccccgg ctacccactc gggcggtttg gagaagccat cactgctctg     1680

acagacatca acggcgatgg gctggtagac gtggctgtgg gggcccctct ggaggagcag     1740

ggggctgtgt acatcttcaa tgggaggcac ggggggctta gtccccagcc aagtcagcgg     1800

atagaaggga cccaagtgct ctcaggaatt cagtggtttg gacgctccat ccatggggtg     1860

aaggaccttg aaggggatgg cttggcagat gtggctgtgg gggctgagag ccagatgatc     1920

gtgctgagct cccggcccgt ggtggatatg gtcaccctga tgtccttctc tccagctgag     1980

atcccagtgc atgaagtgga gtgctcctat tcaaccagta acaagatgaa agaaggagtt     2040

aatatcacaa tctgtttcca gatcaagtct ctcatccccc agttccaagg ccgcctggtt     2100

gccaatctca cttacactct gcagctggat ggccaccgga ccagaagacg ggggttgttc     2160

ccaggaggga gacatgaact cagaaggaat atagctgtca ccaccagcat gtcatgcact     2220

gacttctcat ttcatttccc ggtatgtgtt caagacctca tctcccccat caatgtttcc     2280

ctgaatttct ctctttggga ggaggaaggg acaccgaggg accaaagggc gcagggcaag     2340

gacataccgc ccatcctgag accctccctg cactcggaaa cctgggagat cccttttgag     2400

aagaactgtg gggaggacaa gaagtgtgag gcaaacttga gagtgtcctt ctctcctgca     2460

agatccagag ccctgcgtct aactgctttt gccagcctct ctgtggagct gagcctgagt     2520

aacttggaag aagatgctta ctgggtccag ctggacctgc acttcccccc gggactctcc     2580

ttccgcaagg tggagatgct gaagccccat agccagatac ctgtgagctg cgaggagctt     2640

cctgaagagt ccaggcttct gtccagggca ttatcttgca atgtgagctc tcccatcttc     2700

aaagcaggcc actcggttgc tctgcagatg atgtttaata cactggtaaa cagctcctgg     2760

ggggactcgg ttgaattgca cgccaatgtg acctgtaaca atgaggactc agacctcctg     2820

gaggacaact cagccactac catcatcccc atcctgtacc ccatcaacat cctcatccag     2880

gaccaagaag actccacact ctatgtcagt ttcaccccca aaggccccaa gatccaccaa     2940

gtcaagcaca tgtaccaggt gaggatccag ccttccatcc acgaccacaa catacccacc     3000

ctggaggctg tggttggggt gccacagcct cccagcgagg ggcccatcac acaccagtgg     3060

agcgtgcaga tggagcctcc cgtgccctgc cactatgagg atctggagag gctcccggat     3120

gcagctgagc cttgtctccc cggagccctg ttccgctgcc ctgttgtctt caggcaggag     3180

atcctcgtcc aagtgatcgg gactctggag ctggtgggag agatcgaggc ctcttccatg     3240

ttcagcctct gcagctccct ctccatctcc ttcaacagca gcaagcattt ccacctctat     3300

ggcagcaacg cctccctggc ccaggttgtc atgaaggttg acgtggtgta tgagaagcag     3360

atgctctacc tctacgtgct gagcggcatc ggggggctgc tgctgctgct gctcattttc     3420

atagtgctgt acaaggttgg tttcttcaaa cggaacctga aggagaagat ggaggctggc     3480

agaggtgtcc cgaatggaat ccctgcagaa gactctgagc agctggcatc tgggcaagag     3540

gctggggatc ccggctgcct gaagcccctc catgagaagg actctgagag tggtggtggc     3600

aaggactgag tccaggcctg tgaggtgcag agtgcccaga actggactca ggatgcccag     3660

ggccactctg cctctgcctg cattctgccg tgtgccctcg ggcgagtcac tgcctctccc     3720

tggccctcag tttccctatc tcgaacatgg aactcattcc tgcctgtctc ctttgcaggc     3780

tcatagggaa gacctgctga gggaccagcc aagagggctg caaaagtgag ggcttgtcat     3840

taccagacgg ttcaccagcc tctcttggtt tccttccttg gaagagaatg tctgatctaa     3900

atgtggagaa actgtagtct caggacctag ggatgttctg gccctcaccc ctgccctggg     3960

atgtccacag atgcctccac cccccagaac ctgtccttgc acactcccct gcactggagt     4020

ccagtctctt ctgctggcag aaagcaaatg tgacctgtgt cactacgtga ctgtggcaca     4080

cgccttgttc ttggccaaag accaaattcc ttggcatgcc ttccagcacc ctgcaaaatg     4140

agaccctcgt ggccttcccc agcctcttct agagccgtga tgcctccctg ttgaagctct     4200

ggtgacacca gcctttctcc caggccaggc tccttcctgt cttcctgcat tcacccagac     4260

agctccctct gcctgaacct tccatctcgc cacccctcct tccttgacca gcagatccca     4320

gctcacgtca cacttggttg ggtcctcaca tctttcacac ttccaccagc ctgcactact     4380

ccctcaaagc acacgtcatg tttcttcatc cggcagcctg gatgtttttt ccctgtttaa     4440

tgattgacgt acttagcagc tatctctcag tgaactgtga gggtaaaggc tatacttgtc     4500

ttgttcacct tgggatgatg cctcatgata tgtcagggcg tgggacatct agtaggtgct     4560

tgacataatt tcactgaatt aatgacagag ccagtgggaa gatacagaaa aagaggggct     4620

gggctgggcg cggtggttca cgcctgtaat cccagcactt tgggaggcca aggagggtgg     4680

atcacctgag gtcaggagtt agaggccagc ctggcgaaac cccatctcta ctaaaaatac     4740

aaaatccagg cgtggtggca cacacctgta gtcccagcta ctcaggaggt tgaggtagga     4800

gaattgcttg aacctgggag gtggaggttg cagtgagcca agattgcgcc attgcactcc     4860

agcctgggca acacagcgag actccgtctc aaggaaaaaa taaaaataaa aagcgggcac     4920

gggcccgtga catccccacc cttggaggct gtcttctcag gctctgccct gccctagctc     4980

cacaccctct cccaggaccc atcacgcctg tgcagtggcc cccacagaaa gactgagctc     5040

aaggtgggaa ccacgtctgc taacttggag ccccagtgcc aagcacagtg cctgcatgta     5100

tttatccaat aaatgtgaaa ttctgtcca                                       5129


<210>  19
<211>  589
<212>  PRT
<213>  Homo sapiens

<400>  19

Asn Pro Glu Gly Gly His Phe Asp Ser Leu Leu Met Leu Pro Leu Pro 
1               5                   10                  15      


Pro Ser Leu Pro Glu Asp Thr Ile Ser Thr Leu Thr Gln His Asp Arg 
            20                  25                  30          


Asn Ile Gln Pro Asn Phe Ser Pro Ile Cys Gly His Trp Thr Ala His 
        35                  40                  45              


Gln His Glu Asn Phe Tyr Val Phe Thr Tyr Cys Phe Ser Tyr His Pro 
    50                  55                  60                  


Asp Asp Trp Val Ser Thr Phe Cys Cys Val Ser Ser Lys Val Gly Gln 
65                  70                  75                  80  


Asp Arg Arg Lys Glu Ser Ser Arg Phe Cys Ile His Glu Asn Asp Thr 
                85                  90                  95      


Glu Met Gln His Arg Arg Lys Ile Leu Ile Leu Thr Glu Leu Gly Asp 
            100                 105                 110         


Lys Pro Val Arg Leu Cys Glu Gly Tyr Asn Val Lys Gln Arg Gly Asp 
        115                 120                 125             


Glu Glu Arg Lys Gln Leu Asn Ala Lys Arg Ser Glu Ser Ser Asn Cys 
    130                 135                 140                 


Gly Thr Cys His Lys Gly Gln Gln Asn Asn Ile Cys Val Thr Val Gly 
145                 150                 155                 160 


Lys Arg Ile Leu His His Glu Gln Gln Leu Gly Asn Pro Gly Lys Trp 
                165                 170                 175     


Glu Thr Ala Asp Arg Lys Thr Arg Thr Leu Leu Tyr Leu Cys Pro Ser 
            180                 185                 190         


His Leu Leu Phe Gln Ser Gly Ser Phe Glu Ser Ser Ser Ile Tyr Ser 
        195                 200                 205             


Gln Pro Leu Pro Lys Val Pro Arg Ile Arg Glu Asn Leu Thr Gln Ser 
    210                 215                 220                 


Cys Lys Tyr Pro Gln Phe Arg Gln Thr Leu Arg Ala Thr Ile His Ser 
225                 230                 235                 240 


Leu Gly Arg Ser Ile Ile Ala Thr Arg Cys Phe Gly Val Cys Gln Cys 
                245                 250                 255     


Asp Ser Lys Pro Ser Glu Pro Trp His Trp Leu His Val Leu Trp Leu 
            260                 265                 270         


Thr Gln Thr Leu Asn Ser Val Thr Leu Gln Ala Val Val Glu Leu Thr 
        275                 280                 285             


Leu Gly Val Phe Ile Ile Gln His Ser Gly Ala His Pro Leu Leu Thr 
    290                 295                 300                 


Ala Tyr Leu Pro Asp Pro Pro Tyr Gly Glu Leu Phe Ile Ile His Ser 
305                 310                 315                 320 


Lys Ala Cys Arg Thr Val Ile Ser Glu Leu Gln Val Thr Asn Gln Asn 
                325                 330                 335     


Gly Pro Cys Ser Ile Arg Ala Tyr Ile Ser Glu Ala Ala Thr Pro Leu 
            340                 345                 350         


Met Gln Thr Ser Arg Glu Ser Tyr Glu Lys Thr Arg Pro Leu Cys Thr 
        355                 360                 365             


Gly Ile Leu Ser Lys Gln Gln Ile Thr Cys Gln Val Gln Phe Cys Phe 
    370                 375                 380                 


Phe Ala Cys Ser Val Phe Pro Trp Ile Met His Leu Ile Tyr Gln Arg 
385                 390                 395                 400 


Cys Arg Arg Glu Met Gly Ser Leu Ser Ser His Ser Val Met Val Asp 
                405                 410                 415     


Ser Gly Phe Leu Trp Pro Cys Trp Arg Gly Pro Gly Ser Arg Thr Ser 
            420                 425                 430         


Asn Thr Val Glu Asn Arg Asn Pro Pro Pro Pro Pro Ala Thr Leu Ser 
        435                 440                 445             


Asp Ser Tyr Ser Phe Ser Phe Asn Leu Ser Leu Ser Ile Ser Leu Phe 
    450                 455                 460                 


Gln Ser Leu Ser Leu Asn Leu Phe Leu Pro Ile Ser Leu Ser Gln Ser 
465                 470                 475                 480 


Leu Cys Phe Pro Leu Ser Val Ser Ser Leu Pro Gln Ser Leu Phe Ser 
                485                 490                 495     


Ile Pro Leu Ser Asn Thr His Thr His Thr His Thr His Thr His Thr 
            500                 505                 510         


His Thr His Thr His Thr Glu Ser Gly Arg Cys Ser Val Leu Phe Phe 
        515                 520                 525             


Pro Pro Cys Pro Tyr Leu Tyr His Tyr Arg Gly Gly Val Gly Ser Ala 
    530                 535                 540                 


Ala Leu Ser Leu Pro Thr Pro His Tyr Glu Met Thr Val Phe Lys Gly 
545                 550                 555                 560 


Asn Leu Leu Tyr Leu Pro Ala Val Ser Ile Val Ser Arg Val Asn Leu 
                565                 570                 575     


Leu Ser Cys Tyr Leu Phe Phe Glu Arg Pro Leu Asn Ile 
            580                 585                 


<210>  20
<211>  1852
<212>  DNA
<213>  Homo sapiens

<400>  20
aatcctgagt aaggtggcca ctttgacagt cttctcatgc tgcctctgcc accttctctg       60

ccagaagata ccatttcaac tttaacacag catgatcgaa acatacaacc aaacttctcc      120

ccgatctgcg gccactggac tgcccatcag catgaaaatt tttatgtatt tacttactgt      180

ttttcttatc acccagatga ttgggtcagc actttttgct gtgtatcttc atagaaggtt      240

ggacaagata gaagatgaaa ggaatcttca tgaagatttt gtattcatga aaacgataca      300

gagatgcaac acaggagaaa gatccttatc cttactgaac tgtgaggaga ttaaaagcca      360

gtttgaaggc tttgtgaagg atataatgtt aaacaaagag gagacgaaga aagaaaacag      420

ctttgaaatg caaaaaggtg atcagaatcc tcaaattgcg gcacatgtca taagtgaggc      480

cagcagtaaa acaacatctg tgttacagtg ggctgaaaaa ggatactaca ccatgagcaa      540

caacttggta accctggaaa atgggaaaca gctgaccgtt aaaagacaag gactctatta      600

tatctatgcc caagtcacct tctgttccaa tcgggaagct tcgagtcaag ctccatttat      660

agccagcctc tgcctaaagt cccccggtag attcgagaga atcttactca gagctgcaaa      720

tacccacagt tccgccaaac cttgcgggca acaatccatt cacttgggag gagtatttga      780

attgcaacca ggtgcttcgg tgtttgtcaa tgtgactgat ccaagccaag tgagccatgg      840

cactggcttc acgtcctttg gcttactcaa actctgaaca gtgtcacctt gcaggctgtg      900

gtggagctga cgctgggagt cttcataata cagcacagcg gttaagccca ccccctgtta      960

actgcctatt tataacccta ggatcctcct tatggagaac tatttattat acactccaag     1020

gcatgtagaa ctgtaataag tgaattacag gtcacatgaa accaaaacgg gccctgctcc     1080

ataagagctt atatatctga agcagcaacc ccactgatgc agacatccag agagtcctat     1140

gaaaagacaa ggccattatg cacaggttga attctgagta aacagcagat aacttgccaa     1200

gttcagtttt gtttctttgc gtgcagtgtc tttccatgga taatgcattt gatttatcag     1260

tgaagatgca gaagggaaat ggggagcctc agctcacatt cagttatggt tgactctggg     1320

ttcctatggc cttgttggag ggggccaggc tctagaacgt ctaacacagt ggagaaccga     1380

aacccccccc ccccccccgc caccctctcg gacagttatt cattctcttt caatctctct     1440

ctctccatct ctctctttca gtctctctct ctcaacctct ttcttccaat ctctctttct     1500

caatctctct gtttcccttt gtcagtctct tccctccccc agtctctctt ctcaatcccc     1560

ctttctaaca cacacacaca cacacacaca cacacacaca cacacacaca cacacacaca     1620

gagtcaggcc gttgctagtc agttctcttc tttccaccct gtccctatct ctaccactat     1680

agatgagggt gaggagtagg gagtgcagcc ctgagcctgc ccactcctca ttacgaaatg     1740

actgtattta aaggaaatct attgtatcta cctgcagtct ccattgtttc cagagtgaac     1800

ttgtaattat cttgttattt attttttgaa taataaagac ctcttaacat ta             1852


<210>  21
<211>  770
<212>  PRT
<213>  Homo sapiens

<400>  21

Thr Val Leu Arg Ile Leu Gln Ser Ser Leu Leu Gln Ser Pro Leu Leu 
1               5                   10                  15      


His Pro Val Gln Glu Pro Ala Thr Ala Arg Ser Ala Leu Leu Thr Thr 
            20                  25                  30          


Met Ser Leu Leu Ser Ser Arg Ala Ala Arg Val Pro Gly Pro Ser Ser 
        35                  40                  45              


Ser Leu Cys Ala Leu Leu Val Leu Leu Leu Leu Leu Thr Gln Pro Gly 
    50                  55                  60                  


Pro Ile Ala Ser Ala Gly Pro Ala Ala Ala Val Leu Arg Glu Leu Arg 
65                  70                  75                  80  


Cys Val Cys Leu Gln Thr Thr Gln Gly Val His Pro Lys Met Ile Ser 
                85                  90                  95      


Asn Leu Gln Val Phe Ala Ile Gly Pro Gln Cys Ser Lys Val Glu Val 
            100                 105                 110         


Val Ala Ser Leu Lys Asn Gly Lys Glu Ile Cys Leu Asp Pro Glu Ala 
        115                 120                 125             


Pro Phe Leu Lys Lys Val Ile Gln Lys Ile Leu Asp Gly Gly Asn Lys 
    130                 135                 140                 


Glu Asn Leu Arg Glu Met Ser Thr His Gly Lys Val Ser Gln Ser Ser 
145                 150                 155                 160 


Ala Glu Lys Phe Ser Gly Gly Leu Thr Gln Gly Arg Gln Glu Gly Lys 
                165                 170                 175     


Ile Leu Leu Leu Phe Val Tyr Leu Phe Phe Gln Leu Ala Phe Phe Leu 
            180                 185                 190         


Asp Ser Ser Leu Arg Val Gly Lys Pro Met Phe Ala Ala Ala Phe Ser 
        195                 200                 205             


Ser Ala Asn Glu Val Phe Ser Ile Val Pro Leu Leu Phe Ala Val Ile 
    210                 215                 220                 


Leu Ser Ala Met Leu Leu Lys Phe Trp Gln Leu Thr Ile Val Ala Arg 
225                 230                 235                 240 


Asn His Trp Leu Leu Ile Phe Gln Ser Val Leu Asn Cys Arg Leu Leu 
                245                 250                 255     


Tyr Phe Gln Glu Ile Phe Leu Lys Ile Leu Thr Glu Lys Ala Val Asp 
            260                 265                 270         


Leu Met Trp Lys Cys Phe Ile Arg Ile Leu Leu Met Glu Ile His Cys 
        275                 280                 285             


Tyr Leu His Phe Tyr Lys Lys Glu Ile Phe Cys Phe Leu Gly Asn Met 
    290                 295                 300                 


Leu Glu Asn Phe Leu Thr Leu Asp Cys Gly Ile Leu Phe Asn Tyr Phe 
305                 310                 315                 320 


Thr Leu Glu Ser Val Phe His Thr Leu Ser Met Asn Ile Phe Pro Tyr 
                325                 330                 335     


Ser Glu Phe Leu Lys Val Val Leu Gly Leu Ile Ser Tyr Leu Pro Ile 
            340                 345                 350         


Ile Leu Asp Ile Leu Tyr Leu Phe Ser Met Ala Asn Cys His His Leu 
        355                 360                 365             


Leu Leu Asn Phe Asp Phe Ile Cys Tyr Leu Leu Ser Ile Leu Leu Gly 
    370                 375                 380                 


Val Pro Phe Trp Leu Asn Ile Tyr Phe Arg Met Lys Lys Leu Glu Asn 
385                 390                 395                 400 


Arg Gln Ile Pro Asp Cys Phe Ile Lys Cys Ile Leu Leu Val Phe Lys 
                405                 410                 415     


Val Lys Ala Asn Leu Thr Met Thr Cys Thr Leu Lys Val Leu Glu Thr 
            420                 425                 430         


Tyr Ser Asn Asn Leu Asn Ile Asn Leu Ser Phe Ser Tyr Lys Asn Ile 
        435                 440                 445             


Arg His Pro Arg Gly Pro Ser Ile Ser Pro Trp Ile Gly Asp Gln Arg 
    450                 455                 460                 


Glu Leu Gly Met Leu Lys Thr Lys Gln Asn Lys Lys Lys Gln Gly Glu 
465                 470                 475                 480 


Val Val Gln Gly Met Ser Ile Phe Tyr Pro Ser Val Trp Val Arg Phe 
                485                 490                 495     


Ser Lys Ile Ile Ile Arg Arg Pro Ala Phe Met Val Glu Tyr Ile Ile 
            500                 505                 510         


Ile Tyr Lys Val Ala Thr Leu Gly Gln Val Pro Ser Pro Leu Thr Ala 
        515                 520                 525             


Leu Ala Pro Phe Thr Glu Asn Leu Gly Arg Ile Ala Glu Asp Glu Arg 
    530                 535                 540                 


Glu Arg Gly Gly Gln Gly Arg Cys Leu Ser Gly Phe His Ser Ser Phe 
545                 550                 555                 560 


His Trp Asp Phe Glu Ala Phe Leu Ser Glu Cys Lys Ala Cys Ser Ser 
                565                 570                 575     


Pro Gly Gly Thr His Trp Gly Trp Gly Trp Gly Lys Met Arg Asn Arg 
            580                 585                 590         


Leu Val Ser Val Val Leu Ile Ser Leu Ile Met Leu Ser Leu Phe Leu 
        595                 600                 605             


Gln Ile Phe Leu Phe Lys Leu Phe His Leu Cys Leu Glu Ile Leu Pro 
    610                 615                 620                 


Phe Arg Glu Asn Val Thr Leu Val Lys Arg Leu Val Gly Lys Leu Leu 
625                 630                 635                 640 


Pro Phe Phe Leu Thr Phe Lys Gln Thr Val Ile Asn Gly Cys Glu Phe 
                645                 650                 655     


Leu Phe Leu Leu Cys Phe Thr Phe Val Phe Gln Asn Arg Ile Leu Tyr 
            660                 665                 670         


Leu Asn Gly Lys Asn Lys Thr Phe Cys Ala Ile Asn Lys Ala Thr Ala 
        675                 680                 685             


Arg Lys Ile Lys His Phe Leu Val Lys Thr Tyr Val Phe Ile Tyr Tyr 
    690                 695                 700                 


Ile Phe Ile Tyr Asn Ile Tyr Tyr Ile Phe Ser Ile Ala Glu Leu Phe 
705                 710                 715                 720 


Arg Cys Leu Leu Cys Ile Phe Arg Phe Pro Phe Cys Tyr Glu Leu His 
                725                 730                 735     


Ile Tyr Tyr Ile His Tyr Ile Lys Ile Val Leu Phe Tyr Tyr Val Ser 
            740                 745                 750         


His Trp Phe Ile Val Phe Ile Leu Ser Phe Glu Thr Leu Lys Asp Phe 
        755                 760                 765             


Thr Ser 
    770 


<210>  22
<211>  2436
<212>  DNA
<213>  Homo sapiens

<400>  22
acagtgctcc ggatcctcca atcttcgctc ctccaatctc cgctcctcca cccagttcag       60

gaacccgcga ccgctcgcag cgctctcttg accactatga gcctcctgtc cagccgcgcg      120

gcccgtgtcc ccggtccttc gagctccttg tgcgcgctgt tggtgctgct gctgctgctg      180

acgcagccag ggcccatcgc cagcgctggt cctgccgctg ctgtgttgag agagctgcgt      240

tgcgtttgtt tacagaccac gcaaggagtt catcccaaaa tgatcagtaa tctgcaagtg      300

ttcgccatag gcccacagtg ctccaaggtg gaagtggtag cctccctgaa gaacgggaag      360

gaaatttgtc ttgatccaga agcccctttt ctaaagaaag tcatccagaa aattttggac      420

ggtggaaaca aggaaaactg attaagagaa atgagcacgc atggaaaagt ttcccagtct      480

tcagcagaga agttttctgg aggtctctga acccagggaa gacaagaagg aaagattttg      540

ttgttgtttg tttatttgtt tttccagtag ttagctttct tcctggattc ctcactttga      600

agagtgtgag gaaaacctat gtttgccgct taagctttca gctcagctaa tgaagtgttt      660

agcatagtac ctctgctatt tgctgttatt ttatctgcta tgctattgaa gttttggcaa      720

ttgactatag tgtgagccag gaatcactgg ctgttaatct ttcaaagtgt cttgaattgt      780

aggtgactat tatatttcca agaaatattc cttaagatat taactgagaa ggctgtggat      840

ttaatgtgga aatgatgttt cataagaatt ctgttgatgg aaatacactg ttatcttcac      900

ttttataaga aataggaaat attttaatgt ttcttgggga atatgttaga gaatttcctt      960

actcttgatt gtgggatact atttaattat ttcactttag aaagctgagt gtttcacacc     1020

ttatctatgt agaatatatt tccttattca gaatttctaa aagtttaagt tctatgaggg     1080

ctaatatctt atcttcctat aattttagac attctttatc tttttagtat ggcaaactgc     1140

catcatttac ttttaaactt tgattttata tgctatttat taagtatttt attaggagta     1200

ccataattct ggtagctaaa tatatatttt agatagatga agaagctaga aaacaggcaa     1260

attcctgact gctagtttat atagaaatgt attcttttag tttttaaagt aaaggcaaac     1320

ttaacaatga cttgtactct gaaagttttg gaaacgtatt caaacaattt gaatataaat     1380

ttatcattta gttataaaaa tatatagcga catcctcgag gccctagcat ttctccttgg     1440

ataggggacc agagagagct tggaatgtta aaaacaaaac aaaacaaaaa aaaacaagga     1500

gaagttgtcc aagggatgtc aattttttat ccctctgtat gggttagatt ttccaaaatc     1560

ataatttgaa gaaggccagc atttatggta gaatatataa ttatatataa ggtggccacg     1620

ctggggcaag ttccctcccc actcacagct ttggcccctt tcacagagta gaacctgggt     1680

tagaggattg cagaagacga gcgggagcgg ggagggcagg gaagatgcct gtcgggtttt     1740

tagcacagtt catttcactg ggattttgaa gcatttctgt ctgaatgtaa agcctgttct     1800

agtcctggtg ggacacactg gggttggggg tgggggaaga tgcggtaatg aaaccggtta     1860

gtcagtgttg tcttaatatc cttgataatg ctgtaaagtt tatttttaca aatatttctg     1920

tttaagctat ttcacctttg tttggaaatc cttccctttt aaagagaaaa tgtgacactt     1980

gtgaaaaggc ttgtaggaaa gctcctccct ttttttcttt aaacctttaa atgacaaacc     2040

taggtaatta atggttgtga atttctattt ttgctttgtt tttaatgaac atttgtcttt     2100

cagaatagga ttctgtgata atatttaaat ggcaaaaaca aaacataatt ttgtgcaatt     2160

aacaaagcta ctgcaagaaa aataaaacat ttcttggtaa aaacgtatgt atttatatat     2220

tatatattta tatataatat atattatata tttagcattg ctgagctttt tagatgccta     2280

ttgtgtatct tttaaaggtt ttgaccattt tgttatgagt aattacatat atattacatt     2340

cactatatta aaattgtact tttttactat gtgtctcatt ggttcatagt ctttattttg     2400

tcctttgaat aaacattaaa agatttctaa acttca                               2436


<210>  23
<211>  672
<212>  PRT
<213>  Homo sapiens

<400>  23

Thr Arg Lys Gln Ala Cys Thr Gln Thr Arg His His Ala Ser Pro Arg 
1               5                   10                  15      


Pro Leu Ala Pro Ala Pro Gly Ser Arg Ile Leu Gly Phe Leu Leu Lys 
            20                  25                  30          


Met Gly Phe Ala Pro Asn Pro Leu Arg Leu Gly Gly Gly Leu Arg Leu 
        35                  40                  45              


Asp Pro Leu His Leu Gln Ser Pro Arg Trp Pro Gly Lys Leu His Pro 
    50                  55                  60                  


Val Pro Gln Ser Val Gln Glu His Leu Glu Val Trp Asp Lys Thr Leu 
65                  70                  75                  80  


Lys His Lys Gly Trp Glu Gly Ser Phe Ala Glu Lys Gly Ala Ile Pro 
                85                  90                  95      


Gly Arg Gln Glu Glu Leu His Thr Glu Tyr Pro Pro Gly Ala Pro Gln 
            100                 105                 110         


Gln Trp Ser Ala Gly Ala Glu Asp Gly Val Gln Asp Glu Met Asp Gly 
        115                 120                 125             


Thr Asn Thr Pro Gln Cys Leu Lys Ala Phe Ser Thr Ser Tyr Pro Ala 
    130                 135                 140                 


Pro Ser Arg Asn Ser Arg Val Pro Gly Ser His Ser Asp Leu Leu Ala 
145                 150                 155                 160 


Glu Phe Leu Leu Leu Trp Val Ser Asp Pro Ile Ala Val Ala Pro Arg 
                165                 170                 175     


Gly Gly Ser Asn Glu Ala Gly Cys Cys His Leu Asp Leu Leu Asp His 
            180                 185                 190         


Gln Val Cys Leu His Pro Glu Arg Ala Gln Val Leu Pro Thr Val Glu 
        195                 200                 205             


Ser Pro Trp Glu Asp Cys Asp Leu Pro Ala Ser Gly Cys Arg Trp Glu 
    210                 215                 220                 


Val Pro Leu Gln His Gly Ala Ala Glu Arg Glu Ala Ser Ser Gln Glu 
225                 230                 235                 240 


Gly Asp His Ser Asp Ser Lys Pro His Ala Asp Ser Arg Arg Arg His 
                245                 250                 255     


Ser Asp Pro Phe Leu Leu Gln Phe Gln Pro Gln Cys Tyr Pro Val Met 
            260                 265                 270         


Glu Thr Pro Trp Arg Leu Gly Gly Ala Ile Ala Trp Gly Ala Glu Asp 
        275                 280                 285             


Pro Lys Arg Trp Leu Gly Gln His Asn His Arg Leu Arg Ser Leu Leu 
    290                 295                 300                 


Val Leu Val Gly Leu Pro Cys Arg Pro Glu Cys Pro Val Cys Pro Pro 
305                 310                 315                 320 


Arg Arg Glu Gly Pro Glu Asn Gln Ala Pro Phe Arg Asp Ser Leu Trp 
                325                 330                 335     


Lys Leu Gly Gln Pro Pro Met Leu Leu Lys Gln Pro Pro Gln Arg Ser 
            340                 345                 350         


Pro Val Leu Leu Gly Glu Lys Trp Gln Ala Ser Gly Glu Arg Lys Pro 
        355                 360                 365             


Ala Glu Phe Leu His Leu Pro Arg Arg Cys Trp Glu Leu Gln Leu Leu 
    370                 375                 380                 


Gly Glu Gln Leu His Arg Thr Asp Ser Val Gln Gly Leu Asp Thr Ser 
385                 390                 395                 400 


Ala Val Cys Thr Gln Glu Ala Ala Cys Val His Glu Pro Gly Gly Pro 
                405                 410                 415     


Ser Asp Gly Gly Glu Glu Cys Asn Pro Asp Leu Glu Arg Arg Gln Pro 
            420                 425                 430         


Ser Arg Leu Pro Leu His Leu Val Leu Glu Pro Lys Pro Pro Leu Pro 
        435                 440                 445             


Gln Pro Glu Ala Glu Ile Gly Ala Gly Glu Gly Pro Ala Leu Gly Cys 
    450                 455                 460                 


Leu Leu Val Pro Gly Asp Gln Gln Cys Gly Gln Gly Pro Phe Ala Ser 
465                 470                 475                 480 


Gln His Pro His Arg Leu Leu Pro Gly Asp His Arg Gln Ala Ser Gly 
                485                 490                 495     


Cys Gly Thr Arg Val Leu Pro Arg His Pro His Pro Gly Asn Leu Trp 
            500                 505                 510         


Ala Gln Ala Pro Ala Thr Leu Glu Glu Asp Thr Glu Pro Ala Gly Ala 
        515                 520                 525             


Ser Gly Glu Phe Gln Arg Pro Glu Leu Leu Cys Glu Glu Lys Gly Lys 
    530                 535                 540                 


Gly Pro Pro Leu Arg Pro Pro Leu Pro Gly Met Leu Gln Ser Asn Asp 
545                 550                 555                 560 


Gly Arg Trp His Leu His His Pro Ala Leu Ser Arg Asp Glu His Thr 
                565                 570                 575     


Thr Asn Trp Arg Cys Arg Val Leu Arg Asp Ala Glu Thr Ser Pro Gly 
            580                 585                 590         


Leu Arg His Gly His Leu Phe Ser Ile Ala Gln Ala Pro Ser Gly His 
        595                 600                 605             


Tyr Glu Asn Val Ile Pro Asp Phe Pro Glu Asp Glu Gly Ile His Tyr 
    610                 615                 620                 


Ser Glu Leu Ile Gln Phe Gly Val Gly Glu Arg Pro Gln Ala Gln Glu 
625                 630                 635                 640 


Asn Val Asp Tyr Val Ile Leu Lys His His Trp Met Gly Cys Ser Arg 
                645                 650                 655     


Gly Thr Gly Gly Ser Gly Gly Gln Gly Ser Pro Arg Val Phe Pro Arg 
            660                 665                 670         


<210>  24
<211>  2116
<212>  DNA
<213>  Homo sapiens

<400>  24
acgcggaaac aggcttgcac ccagacacga caccatgcat ctcctcggcc cctggctcct       60

gctcctggtt ctagaatact tggctttctc tgactcaagt aaatgggttt ttgagcaccc      120

tgaaaccctc tacgcctggg agggggcctg cgtctggatc ccctgcacct acagagccct      180

agatggtgac ctggaaagct tcatcctgtt ccacaatcct gagtataaca agaacacctc      240

gaagtttgat gggacaagac tctatgaaag cacaaaggat gggaaggttc cttctgagca      300

gaaaagggtg caattcctgg gagacaagaa taagaactgc acactgagta tccacccggt      360

gcacctcaat gacagtggtc agctggggct gaggatggag tccaagactg agaaatggat      420

ggaacgaata cacctcaatg tctctgaaag gccttttcca cctcatatcc agctccctcc      480

agaaattcaa gagtcccagg aagtcactct gacctgcttg ctgaatttct cctgctatgg      540

gtatccgatc caattgcagt ggctcctaga gggggttcca atgaggcagg ctgctgtcac      600

ctcgacctcc ttgaccatca agtctgtctt cacccggagc gagctcaagt tctccccaca      660

gtggagtcac catgggaaga ttgtgacctg ccagcttcag gatgcagatg ggaagttcct      720

ctccaatgac acggtgcagc tgaacgtgaa gcatcctccc aagaaggtga ccacagtgat      780

tcaaaacccc atgccgattc gagaaggaga cacagtgacc ctttcctgta actacaattc      840

cagtaacccc agtgttaccc ggtatgaatg gaaaccccat ggcgcctggg aggagccatc      900

gcttggggtg ctgaagatcc aaaacgttgg ctgggacaac acaaccatcg cctgcgcagc      960

ttgtaatagt tggtgctcgt gggcctcccc tgtcgccctg aatgtccagt atgccccccg     1020

agacgtgagg gtccggaaaa tcaagcccct ttccgagatt cactctggaa actcggtcag     1080

cctccaatgt gacttctcaa gcagccaccc caaagaagtc cagttcttct gggagaaaaa     1140

tggcaggctt ctggggaaag aaagccagct gaattttgac tccatctccc cagaagatgc     1200

tgggagttac agctgctggg tgaacaactc cataggacag acagcgtcca aggcctggac     1260

acttgaagtg ctgtatgcac ccaggaggct gcgtgtgtcc atgagcccgg gggaccaagt     1320

gatggagggg aagagtgcaa ccctgacctg tgagagcgac gccaaccctc ccgtctccca     1380

ctacacctgg tttgactgga ataaccaaag cctcccctac cacagccaga agctgagatt     1440

ggagccggtg aaggtccagc actcgggtgc ctactggtgc caggggacca acagtgtggg     1500

caagggccgt tcgcctctca gcaccctcac cgtctactat agcccggaga ccatcggcag     1560

gcgagtggct gtgggactcg ggtcctgcct cgccatcctc atcctggcaa tctgtgggct     1620

caagctccag cgacgttgga agaggacaca gagccagcag gggcttcagg agaattccag     1680

cggccagagc ttctttgtga ggaataaaaa ggttagaagg gcccccctct ctgaaggccc     1740

ccactccctg ggatgctaca atccaatgat ggaagatggc attagctaca ccaccctgcg     1800

ctttcccgag atgaacatac cacgaactgg agatgcagag tcctcagaga tgcagagacc     1860

tcccccggac tgcgatgaca cggtcactta ttcagcattg cacaagcgcc aagtgggcac     1920

tatgagaacg tcattccaga ttttccagaa gatgagggga ttcattactc agagctgatc     1980

cagtttgggg tcggggagcg gcctcaggca caagaaaatg tggactatgt gatcctcaaa     2040

cattgacact ggatgggctg cagcagaggc actgggggca gcgggggcca gggaagtccc     2100

cgagttttcc ccagac                                                     2116


<210>  25
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  25

Ala Arg Ser Thr Ser Ser Pro Ala Ala Val Arg Ser Gln Pro Thr Ser 
1               5                   10                  15      


Gly Lys Trp Gln Thr Ile Phe Arg Ser Met Met Arg Tyr Leu Gly Leu 
            20                  25                  30          


Glu Thr Gln Thr Leu Lys Asp Gly Leu Ala His Gly Gly Thr Ser Leu 
        35                  40                  45              


Leu Gly Gln Gly Ala Thr Gln Gly Leu Pro Ile Leu Gly Pro Thr Pro 
    50                  55                  60                  


Gly Arg His Pro Gln Gly Leu Ile Leu Asp Arg His Leu Gln Ala Pro 
65                  70                  75                  80  


Thr Leu Glu His Leu Glu Leu Ile Pro Glu His Leu His Leu Glu Ser 
                85                  90                  95      


Thr Gln Gly His Pro Ala Ala Leu Gly Pro Thr His Leu Leu Asp Ser 
            100                 105                 110         


Gln Val Pro Pro Glu Pro Thr Leu Pro Leu Ala Pro Met Ala Pro Leu 
        115                 120                 125             


Leu Gly His Leu Cys Leu Ile Thr Cys Leu Cys Leu Gly Glu Trp Cys 
    130                 135                 140                 


Leu Ala Cys Gln Phe Trp Ala Arg Ser Pro Met Gln Thr Glu Leu Leu 
145                 150                 155                 160 


Ile Ser Lys Glu Gly Met Met Leu Pro Ser Thr Leu Thr His Ala Ser 
                165                 170                 175     


Met Arg Thr Thr Gly Glu Ser Leu Phe Ala Ile Gln Ser Trp Ile Ile 
            180                 185                 190         


Thr Gly Glu Gly Lys Lys Asp Ser Arg Phe Ser His Leu Lys Val Gly 
        195                 200                 205             


Asn His Ser Lys Tyr Lys Tyr Trp Leu Asn Leu Thr Thr Ser Arg Leu 
    210                 215                 220                 


Gln Met Met Leu Thr Cys Cys Ser Thr Ile Ile Gly Leu Lys Asn Ser 
225                 230                 235                 240 


Met Lys Ser Ala Asn Trp Glu Phe Leu Val Thr Thr Ser Pro Val Leu 
                245                 250                 255     


His Ile Pro Tyr Asn Leu Lys Gly Ala Asp Lys Lys Lys Lys Asn Leu 
            260                 265                 270         


Asn Leu Thr Cys Val Lys Val Ser Cys Ser Leu Val Lys Ile Phe Thr 
        275                 280                 285             


Phe Ile Asn Ile Pro Leu Val Ser His Leu Leu Asn Lys Tyr Tyr Ser 
    290                 295                 300                 


<210>  26
<211>  943
<212>  DNA
<213>  Homo sapiens

<400>  26
gcccgcagca cctcctcgcc agcagccgtc cggagccagc caacgagcgg aaaatggcag       60

acaatttttc gctccatgat gcgttatctg ggtctggaaa cccaaaccct caaggatggc      120

ctggcgcatg ggggaaccag cctgctgggg cagggggcta cccaggggct tcctatcctg      180

gggcctaccc cgggcaggca cccccagggg cttatcctgg acaggcacct ccaggcgcct      240

accctggagc acctggagct tatcccggag cacctgcacc tggagtctac ccagggccac      300

ccagcggccc tggggcctac ccatcttctg gacagccaag tgccaccgga gcctaccctg      360

ccactggccc ctatggcgcc cctgctgggc cactgattgt gccttataac ctgcctttgc      420

ctgggggagt ggtgcctcgc atgctgataa caattctggg cacggtgaag cccaatgcaa      480

acagaattgc tttagatttc caaagaggga atgatgttgc cttccacttt aacccacgct      540

tcaatgagaa caacaggaga gtcattgttt gcaatacaaa gctggataat aactggggaa      600

gggaagaaag acagtcggtt ttcccatttg aaagtgggaa accattcaaa atacaagtac      660

tggttgaacc tgaccacttc aaggttgcag tgaatgatgc tcacttgttg cagtacaatc      720

atcgggttaa aaaactcaat gaaatcagca aactgggaat ttctggtgac atagacctca      780

ccagtgcttc atataccatg atataatctg aaaggggcag attaaaaaaa aaaaaagaat      840

ctaaacctta catgtgtaaa ggtttcatgt tcactgtgag tgaaaatttt tacattcatc      900

aatatccctc ttgtaagtca tctacttaat aaatattaca gtg                        943


<210>  27
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  27

Ile Ser Leu Gly Trp Ser Leu Leu Thr Ala Gly Ala Pro Ala Arg Glu 
1               5                   10                  15      


His Pro Pro Gly Leu Asn His Gly Leu Trp Ser Gly Arg Gln Gln Pro 
            20                  25                  30          


Glu Ser Gln Thr Trp Arg Val Pro Ser Ser Ala Arg Arg Gly Gly Ser 
        35                  40                  45              


Arg Glu Leu Arg Ala Glu Pro Gly Gln Arg Gln Gln Gln Pro Val Pro 
    50                  55                  60                  


Ala Leu Gln Pro Ser Leu Gln Arg Pro Arg Arg Arg Gln His His Arg 
65                  70                  75                  80  


Val Gln Gln Gln Gly Arg Arg Gly Leu Gly Asp Arg Ala Ala Gly Gly 
                85                  90                  95      


Cys Leu Ser Leu Pro Ala Trp Lys Cys Cys Arg Gly Val His His Leu 
            100                 105                 110         


Arg Pro Gly Gln Pro Asp Arg Gln Ala Ala Arg Trp Ile Arg Ile Gln 
        115                 120                 125             


Val Pro Gln Pro Pro Gln Pro Gly Gly His Gln Leu His Gly Ser Arg 
    130                 135                 140                 


Leu Gln Asp Gln Met Cys Gly Leu Leu Lys Ser Ala Ser Pro Trp Pro 
145                 150                 155                 160 


Pro Ile Lys Ala Ala Ala Ser Ala Pro Ser Glu 
                165                 170     


<210>  28
<211>  528
<212>  DNA
<213>  Homo sapiens

<400>  28
atctctctcg ggtggagtct tctgacagct ggtgcgcctg cccgggaaca tcctcctgga       60

ctcaatcatg gcttgtggtc tggtcgccag caacctgaat ctcaaacctg gagagtgcct      120

tcgagtgcga ggcgaggtgg ctcctgacgc taagagcttc gtgctgaacc tgggcaaaga      180

cagcaacaac ctgtgcctgc acttcaaccc tcgcttcaac gcccacggcg acgccaacac      240

catcgtgtgc aacagcaagg acggcggggc ctgggggacc gagcagcggg aggctgtctt      300

tcccttccag cctggaagtg ttgcagaggt gtgcatcacc ttcgaccagg ccaacctgac      360

cgtcaagctg ccagatggat acgaattcaa gttccccaac cgcctcaacc tggaggccat      420

caactacatg gcagctgacg gtgacttcaa gatcaaatgt gtggcctttg actgaaatca      480

gccagcccat ggcccccaat aaaggcagct gcctctgctc cctctgaa                   528


<210>  29
<211>  633
<212>  PRT
<213>  Homo sapiens

<400>  29

Val Gln Leu Leu Gly Phe Leu Trp Leu Pro Ser Leu Leu Glu Pro Gly 
1               5                   10                  15      


Leu His Pro Ser Asn His Val Gln Gly Thr Cys Ser Trp Tyr Ser Trp 
            20                  25                  30          


His His Leu Leu Leu Cys Gly Cys Phe Pro Ala Arg Lys Ser Arg Asp 
        35                  40                  45              


Asn Cys Gln Ser Gly Lys Pro Asn His Ser Lys Leu Cys Arg Leu Tyr 
    50                  55                  60                  


Gly His Thr Val Asp Arg Cys Arg Lys Glu Ser Ser Cys Asn Glu Pro 
65                  70                  75                  80  


His Gln His Ser Phe Cys Gln Thr Ser Asp Trp Thr Gln Ile Cys Cys 
                85                  90                  95      


Cys Pro Val Tyr Glu Thr Leu Ala Leu Tyr Gly Gly Glu Cys Trp Gln 
            100                 105                 110         


Ala Gln Gly Pro Ser Arg Ile Gln Gly Arg Asp Gln Lys Leu Leu Ser 
        115                 120                 125             


Arg Gly Gly Val Phe Tyr Gly Ser Asp Lys Asp Glu Gly Asn Cys Arg 
    130                 135                 140                 


Ser Leu Pro Trp Glu Asp Cys Tyr Gln Cys Cys Gly His Ser Ala Ser 
145                 150                 155                 160 


Leu Leu Leu Ser Ala Ser Gly Tyr Gln Arg Cys Trp Asn Tyr Cys Trp 
                165                 170                 175     


Ser Gln Cys Thr Asn Tyr Ala Asn Cys Cys Cys Tyr Cys Leu Arg Leu 
            180                 185                 190         


Arg Gln Lys Gly Trp Ser Arg Lys Lys Arg Ala His Leu Pro Gly Arg 
        195                 200                 205             


Trp His Phe Cys Val Asn Pro His Tyr Gly Trp Asn Leu Gly Gln Val 
    210                 215                 220                 


Tyr Ser Trp Arg His Pro Leu Gly Trp Arg Arg Phe Gln Pro Asn Gly 
225                 230                 235                 240 


Gln Pro Phe Tyr Cys Val Ala Gln Ala Glu Gly His Gln Glu Gln Glu 
                245                 250                 255     


Ser Cys Lys Thr Pro Pro Tyr Cys Leu Thr Cys Ala Tyr Pro Leu Phe 
            260                 265                 270         


Gln His Pro Gly Gln Tyr Asp Arg Phe Ser Leu Arg Asn Arg Leu Leu 
        275                 280                 285             


Tyr Leu His Tyr Pro Cys Pro Ile Arg Thr Glu Cys Pro Val Pro Trp 
    290                 295                 300                 


His Pro Gly Pro Ser Arg Glu Ser Pro Ser Arg Cys Gln Thr Arg Gln 
305                 310                 315                 320 


Val Thr Asp Ser Tyr Cys Pro Gly Trp Trp Phe Tyr Ser Tyr Pro Gln 
                325                 330                 335     


Asp Ser Glu Ala Ser Pro Arg Leu Leu Gln Trp Lys Arg Thr Glu Glu 
            340                 345                 350         


His Gln Pro Ser Cys Cys Leu Trp Cys Ser Cys Pro Gly Ser His Leu 
        355                 360                 365             


Val Trp Arg Gln Val Glu Cys Ser Arg Phe Ala Ala Leu Gly Cys His 
    370                 375                 380                 


Ser Ser Phe Pro Trp Tyr Asn Cys Trp Trp Ser His Asp Cys Pro His 
385                 390                 395                 400 


Gln Ala Tyr His His Ser Tyr Gln Ala Asp Thr Asp Leu His Tyr Leu 
                405                 410                 415     


Phe Gln Pro Ala Trp Cys Ala Tyr Ser Gly Leu Arg Arg Ala Cys His 
            420                 425                 430         


Asp Lys Gly Gln Pro Ala Trp Gln Val Thr His Arg His Thr Ser Cys 
        435                 440                 445             


Thr Pro Arg Cys Ser Ser Asp Ser His Phe His Cys Gln Trp Tyr Thr 
    450                 455                 460                 


Gln Cys Leu Cys Cys Gly Gln Glu Tyr Gly Lys Arg Glu Gln Asp Tyr 
465                 470                 475                 480 


Tyr His Gln Gly Pro Phe Glu Gln Gly Arg His Thr Tyr Gly Pro Gly 
                485                 490                 495     


Ser Glu Val Gln Ser Arg Glu Ala Glu Gly Gln Gly Val Ile Gln Glu 
            500                 505                 510         


Phe Thr Val Leu Cys Leu Gln His Glu Ser Asn Cys Arg Glu Thr Ser 
        515                 520                 525             


Arg Gln Asp Arg Gly Gln Thr Glu Asp Ser Gly Gln Val Asn Tyr Gln 
    530                 535                 540                 


Leu Ala Glu Ser Asp Cys Glu Gly Arg Ile Thr Ser Thr Glu Arg Ala 
545                 550                 555                 560 


Gly Glu Ser Leu Gln Pro His His His Gln Ala Val Pro Glu Cys Arg 
                565                 570                 575     


Arg His Ala Arg Arg Asn Ala Trp Gly Ile Ser Trp Trp Trp Ser Ser 
            580                 585                 590         


Ser Leu Trp Trp Cys Phe Leu Arg Ala His His Arg Gly Leu Ser Gln 
        595                 600                 605             


Pro Ser Val Asp Val Ala Leu Phe His Thr Phe Lys Thr Phe Glu Gly 
    610                 615                 620                 


Pro Lys Phe Val Ala Asn Ser Val Ala 
625                 630             


<210>  30
<211>  2085
<212>  DNA
<213>  Homo sapiens

<400>  30
gtgcagctct tgggtttttt gtggcttcct tcgttattgg agccaggcct acaccccagc       60

aaccatgtcc aagggacctg cagttggtat tgatcttggc accacctact cttgtgtggg      120

tgttttccag cacggaaaag tcgagataat tgccaatgat cagggaaacc gaaccactcc      180

aagctatgtc gcctttacgg acactgaacg gttgatcggt gatgccgcaa agaatcaagt      240

tgcaatgaac cccaccaaca cagtttttga tgccaaacgt ctgattggac gcagatttga      300

tgatgctgtt gtccagtctg atatgaaaca ttggcccttt atggtggtga atgatgctgg      360

caggcccaag gtccaagtag aatacaaggg agagaccaaa agcttctatc cagaggaggt      420

gtcttctatg gttctgacaa agatgaagga aattgcagaa gcctaccttg ggaagactgt      480

taccaatgct gtggtcacag tgccagctta ctttaatgac tctcagcgtc aggctaccaa      540

agatgctgga actattgctg gtctcaatgt acttagaatt attaatgagc caactgctgc      600

tgctattgct tacggcttag acaaaaaggt tggagcagaa agaaacgtgc tcatctttga      660

cctgggaggt ggcacttttg atgtgtcaat cctcactatt gaggatggaa tctttgaggt      720

caagtctaca gctggagaca cccacttggg tggagaagat tttgacaacc gaatggtcaa      780

ccattttatt gctgagttta agcgcaagca taagaaggac atcagtgaga acaagagagc      840

tgtaagacgc ctccgtactg cttgtgaacg tgctaagcgt accctctctt ccagcaccca      900

ggccagtatt gagatcgatt ctctctatga aggaatcgac ttctatacct ccattacccg      960

tgcccgattt gaagaactga atgctgacct gttccgtggc accctggacc cagtagagaa     1020

agcccttcga gatgccaaac tagacaagtc acagattcat gatattgtcc tggttggtgg     1080

ttctactcgt atccccaaga ttcagaagct tctccaagac ttcttcaatg gaaaagaact     1140

gaataagagc atcaaccctg atgaagctgt tgcttatggt gcagctgtcc aggcagccat     1200

cttgtctgga gacaagtctg agaatgttca agatttgctg ctcttggatg tcactcctct     1260

ttcccttggt attgaaactg ctggtggagt catgactgtc ctcatcaagc gtaataccac     1320

cattcctacc aagcagacac agaccttcac tacctattct gacaaccagc ctggtgtgct     1380

tattcaggtt tatgaaggcg agcgtgccat gacaaaggat aacaacctgc ttggcaagtt     1440

tgaactcaca ggcatacctc ctgcaccccg aggtgttcct cagattgaag tcacttttga     1500

cattgatgcc aatggtatac tcaatgtctc tgctgtggac aagagtacgg gaaaagagaa     1560

caagattact atcactaatg acaagggccg tttgagcaag gaagacattg aacgtatggt     1620

ccaggaagct gagaagtaca aagctgaaga tgagaagcag agggacaagg tgtcatccaa     1680

gaattcactt gagtcctatg ccttcaacat gaaagcaact gttgaagatg agaaacttca     1740

aggcaagatt aacgatgagg acaaacagaa gattctggac aagtgtaatg aaattatcaa     1800

ctggcttgat aagaatcaga ctgctgagaa ggaagaattt gaacatcaac agaaagagct     1860

ggagaaagtt tgcaacccca tcatcaccaa gctgtaccag agtgcaggag gcatgccagg     1920

aggaatgcct gggggatttc ctggtggtgg agctcctccc tctggtggtg cttcctcagg     1980

gcccaccatt gaagaggttg attaagccaa ccaagtgtag atgtagcatt gttccacaca     2040

tttaaaacat ttgaaggacc taaattcgta gcaaattctg tggca                     2085


<210>  31
<211>  407
<212>  PRT
<213>  Homo sapiens

<400>  31

Asp Gln Pro Thr Ala Ala Cys Ile Cys Ile Gln Arg Gln Val Pro Pro 
1               5                   10                  15      


Val Pro Ala Ala Arg Ala Pro Gln Ser Arg Thr Arg Ser Ala Gln Ala 
            20                  25                  30          


Lys Leu Ala Leu Thr Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys 
        35                  40                  45              


Tyr Leu Leu Phe Gly Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala 
    50                  55                  60                  


Val Leu Ala Ile Gly Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser 
65                  70                  75                  80  


Ile Phe Glu Gln Glu Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly 
                85                  90                  95      


Val Tyr Ile Leu Ile Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe 
            100                 105                 110         


Leu Gly Cys Cys Gly Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu 
        115                 120                 125             


Phe Phe Gly Phe Leu Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala 
    130                 135                 140                 


Ile Trp Gly Tyr Ser His Lys Asp Glu Val Ile Lys Glu Val Gln Glu 
145                 150                 155                 160 


Phe Tyr Lys Asp Thr Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln 
                165                 170                 175     


Arg Glu Thr Leu Lys Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu 
            180                 185                 190         


Ala Gly Gly Val Glu Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp 
        195                 200                 205             


Val Leu Glu Thr Phe Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu 
    210                 215                 220                 


Val Phe Asp Asn Lys Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile 
225                 230                 235                 240 


Ala Val Val Met Ile Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys 
                245                 250                 255     


Ala Ile Arg Arg Asn Arg Glu Met Val Ser Gln Leu Thr Ser Leu Ser 
            260                 265                 270         


Arg Lys Val Tyr Pro Arg Leu Val Gly Phe Phe Val Cys Leu Phe Cys 
        275                 280                 285             


Phe Val Cys Cys Leu Leu Phe Val Phe Leu Pro Leu Ile Leu Val Phe 
    290                 295                 300                 


Ile Leu His Cys Ile Lys Ala Glu Val Thr Leu Cys Leu Ser Phe Asn 
305                 310                 315                 320 


Ala Ser Phe Asn Ile Asp Ile Cys Ser Ala Gly Gly Leu Val Cys Phe 
                325                 330                 335     


Gly Leu Tyr Phe Phe Ser Cys Leu Phe Leu Leu Val Ile Leu Ser Arg 
            340                 345                 350         


Asn Pro Ala Met Lys Gly Thr Ile Phe Ala Arg Leu Thr Arg Tyr Cys 
        355                 360                 365             


Thr Lys Asn Phe Phe Val Phe Lys Ile Gln Met Ser Ile Asn Phe Asn 
    370                 375                 380                 


Gln Val Val Thr Tyr Ile Glu Asp Asn Leu Ile His Asn Lys Lys Leu 
385                 390                 395                 400 


Gln Cys Gln Lys Lys Lys Lys 
                405         


<210>  32
<211>  1246
<212>  DNA
<213>  Homo sapiens

<400>  32
gaccagccta cagccgcctg catctgtatc cagcgccagg tcccgccagt cccagctgcg       60

cgcgcccccc agtcccgcac ccgttcggcc caggctaagt tagccctcac catgccggtc      120

aaaggaggca ccaagtgcat caaatacctg ctgttcggat ttaacttcat cttctggctt      180

gccgggattg ctgtccttgc cattggacta tggctccgat tcgactctca gaccaagagc      240

atcttcgagc aagaaactaa taataataat tccagcttct acacaggagt ctatattctg      300

atcggagccg gcgccctcat gatgctggtg ggcttcctgg gctgctgcgg ggctgtgcag      360

gagtcccagt gcatgctggg actgttcttc ggcttcctct tggtgatatt cgccattgaa      420

atagctgcgg ccatctgggg atattcccac aaggatgagg tgattaagga agtccaggag      480

ttttacaagg acacctacaa caagctgaaa accaaggatg agccccagcg ggaaacgctg      540

aaagccatcc actatgcgtt gaactgctgt ggtttggctg ggggcgtgga acagtttatc      600

tcagacatct gccccaagaa ggacgtactc gaaaccttca ccgtgaagtc ctgtcctgat      660

gccatcaaag aggtcttcga caataaattc cacatcatcg gcgcagtggg catcggcatt      720

gccgtggtca tgatatttgg catgatcttc agtatgatct tgtgctgtgc tatccgcagg      780

aaccgcgaga tggtctagag tcagcttaca tccctgagca ggaaagttta cccatgaaga      840

ttggtgggat tttttgtttg tttgttttgt tttgtttgtt gtttgttgtt tgtttttttg      900

ccactaattt tagtattcat tctgcattgc tagataaaag ctgaagttac tttatgtttg      960

tcttttaatg cttcattcaa tattgacatt tgtagttgag cggggggttt ggtttgcttt     1020

ggtttatatt ttttcagttg tttgtttttg cttgttatat taagcagaaa tcctgcaatg     1080

aaaggtacta tatttgctag actctagaca agatattgta cataaaagaa tttttttgtc     1140

tttaaataga tacaaatgtc tatcaacttt aatcaagttg taacttatat tgaagacaat     1200

ttgatacata ataaaaaatt atgacaatgt caaaaaaaaa aaaaaa                    1246


<210>  33
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val 
1               5                   10                  15      


Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly 
            20                  25                  30          


Val Gly Ala Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala Thr 
        35                  40                  45              


Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu 
    50                  55                  60                  


Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr 
65                  70                  75                  80  


Cys Leu Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val 
                85                  90                  95      


Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met 
            100                 105                 110         


Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys 
        115                 120                 125             


Asn Asn His Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys 
    130                 135                 140                 


Cys Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro Ser Met 
145                 150                 155                 160 


Ser Lys Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr Val Gly 
                165                 170                 175     


Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val 
            180                 185                 190         


Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala 
        195                 200                 205             


Ala Ala Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe Ala 
    210                 215                 220                 


Cys Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met 
225                 230                 235             


<210>  34
<211>  714
<212>  DNA
<213>  Homo sapiens

<400>  34
atggcggtgg aaggaggaat gaaatgtgtg aagttcttgc tctacgtcct cctgctggcc       60

ttttgcgcct gtgcagtggg actgattgcc gtgggtgtcg gggcacagct tgtcctgagt      120

cagaccataa tccagggggc tacccctggc tctctgttgc cagtggtcat catcgcagtg      180

ggtgtcttcc tcttcctggt ggcttttgtg ggctgctgcg gggcctgcaa ggagaactat      240

tgtcttatga tcacgtttgc catctttctg tctcttatca tgttggtgga ggtggccgca      300

gccattgctg gctatgtgtt tagagataag gtgatgtcag agtttaataa caacttccgg      360

cagcagatgg agaattaccc gaaaaacaac cacactgctt cgatcctgga caggatgcag      420

gcagatttta agtgctgtgg ggctgctaac tacacagatt gggagaaaat cccttccatg      480

tcgaagaacc gagtccccga ctcctgctgc attaatgtta ctgtgggctg tgggattaat      540

ttcaacgaga aggcgatcca taaggagggc tgtgtggaga agattggggg ctggctgagg      600

aaaaatgtgc tggtggtagc tgcagcagcc cttggaattg cttttgtcga ggttttggga      660

attgtctttg cctgctgcct cgtgaagagt atcagaagtg gctacgaggt gatg            714


<210>  35
<211>  487
<212>  PRT
<213>  Homo sapiens

<400>  35

Gly Gln Arg Ala Ser Ala Gln Arg Arg Arg Arg Arg Arg Pro His Arg 
1               5                   10                  15      


Ala Ser Cys Gln Ala Ser Gly Ala Gln Arg Pro Thr Arg Pro Arg Ala 
            20                  25                  30          


Pro Ala Pro Pro Arg Pro Phe Leu Arg Ala Pro Ala Pro Arg Pro Ala 
        35                  40                  45              


Arg Pro Pro Cys Arg Pro Pro Ala Arg Pro Arg Ala Gly Pro Pro Ala 
    50                  55                  60                  


Ala Gln Asp Arg Pro Ala Pro Arg Arg Pro Pro Ala Ala Arg Ala Ala 
65                  70                  75                  80  


Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val 
                85                  90                  95      


Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala 
            100                 105                 110         


Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu 
        115                 120                 125             


Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile 
    130                 135                 140                 


Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys 
145                 150                 155                 160 


Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr 
                165                 170                 175     


Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly 
            180                 185                 190         


Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
        195                 200                 205             


Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys 
    210                 215                 220                 


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
225                 230                 235                 240 


Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro 
                245                 250                 255     


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
            260                 265                 270         


Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala 
        275                 280                 285             


Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met 
    290                 295                 300                 


Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr Gly Pro Ala Ala 
305                 310                 315                 320 


Leu Ala Thr Gly Thr Ser Ala Val Pro Pro Lys Pro Gly His Phe Arg 
                325                 330                 335     


Gly Gly His His Arg Leu Cys Ile Arg Phe Arg Tyr Tyr Ser Ala Thr 
            340                 345                 350         


Arg Ser Leu Phe Thr Phe Gly Val Leu Phe Leu Phe Thr Phe Leu Leu 
        355                 360                 365             


Pro Phe Gln Gly Arg His Met Val Ala Cys Met Ser Gly Asp Gly Pro 
    370                 375                 380                 


Gly Ser Trp Gly Leu Glu Gly Arg Gly Pro Ser Ala Leu Gly Ser Gln 
385                 390                 395                 400 


Gly Ala Leu Pro Ala Gln Pro Gly Leu Ser Trp Glu Pro Leu Ala Gln 
                405                 410                 415     


Arg Leu Ser Leu Ala Asn Leu Gly Gly Cys Val His Pro Ala Arg Pro 
            420                 425                 430         


Ser Cys Gly Leu His Ser Ser Pro Cys Ser Leu Leu Pro Arg Phe Glu 
        435                 440                 445             


Ser Arg Val Cys Gly His Ser Leu Pro Ser Cys Thr Cys Pro Phe His 
    450                 455                 460                 


Val Ala Phe Asn Cys Asn His Asn Ile Leu Thr Pro Ser Phe Asn Lys 
465                 470                 475                 480 


Glu Gly Thr Ser Gly Met Leu 
                485         


<210>  36
<211>  1482
<212>  DNA
<213>  Homo sapiens

<400>  36
ggccagagag cgagcgcgca acggcggcga cggcggcgac cccaccgcgc atcctgccag       60

gcctccggcg cccagcgccc cacgcgcccc cgcgcccccg cgcccccgcg cccctttctt      120

cgcgcccccg cccctcggcc cgccaggccc ccttgccggc cacccgccag gccccgcgcc      180

ggcccgcccg ccgcccagga ccggcccgcg ccccgcaggc cgcccgccgc ccgcgccgcc      240

atgggagtgg agggctgcac caagtgcatc aagtacctgc tcttcgtctt caatttcgtc      300

ttctggctgg ctggaggcgt gatcctgggt gtggccctgt ggctccgcca tgacccgcag      360

accaccaacc tcctgtatct ggagctggga gacaagcccg cgcccaacac cttctatgta      420

ggcatctaca tcctcatcgc tgtgggcgct gtcatgatgt tcgttggctt cctgggctgc      480

tacggggcca tccaggaatc ccagtgcctg ctggggacgt tcttcacctg cctggtcatc      540

ctgtttgcct gtgaggtggc cgccggcatc tggggctttg tcaacaagga ccagatcgcc      600

aaggatgtga agcagttcta tgaccaggcc ctacagcagg ccgtggtgga tgatgacgcc      660

aacaacgcca aggctgtggt gaagaccttc cacgagacgc ttgactgctg tggctccagc      720

acactgactg ctttgaccac ctcagtgctc aagaacaatt tgtgtccctc gggcagcaac      780

atcatcagca acctcttcaa ggaggactgc caccagaaga tcgatgacct cttctccggg      840

aagctgtacc tcatcggcat tgctgccatc gtggtcgctg tgatcatgat cttcgagatg      900

atcctgagca tggtgctgtg ctgtggcatc cggaacagct ccgtgtactg aggccccgca      960

gctctggcca cagggacctc tgcagtgccc cctaagtgac ccggacactt ccgagggggc     1020

catcaccgcc tgtgtatata acgtttccgg tattactctg ctacacgtag cctttttact     1080

tttggggttt tgtttttgtt ctgaactttc ctgttacctt ttcagggctg acgtcacatg     1140

taggtggcgt gtatgagtgg agacgggcct gggtcttggg gactggaggg caggggtcct     1200

tctgccctgg ggtcccaggg tgctctgcct gctcagccag gcctctcctg ggagccactc     1260

gcccagagac tcagcttggc caacttgggg ggctgtgtcc acccagcccg cccgtcctgt     1320

gggctgcaca gctcaccttg ttccctcctg ccccggttcg agagccgagt ctgtgggcac     1380

tctctgcctt catgcacctg tcctttctaa cacgtcgcct tcaactgtaa tcacaacatc     1440

ctgactccgt catttaataa agaaggaaca tcaggcatgc ta                        1482


<210>  37
<211>  1484
<212>  PRT
<213>  Homo sapiens

<400>  37

Lys Gly Arg Pro Trp Pro Leu Trp Ser Gly Pro Arg Ala Ala Ala Arg 
1               5                   10                  15      


Pro Phe Pro Arg Gly Pro Leu Leu Arg Arg Ala Pro Gly Pro His Pro 
            20                  25                  30          


Ser Gln His Pro Ala Pro Arg Ala Leu Pro Ala Gly Ser Ser Arg Ser 
        35                  40                  45              


His Gly Ala Gly Ala Ala Val Ser Thr Met Glu Leu Ala Ala Leu Cys 
    50                  55                  60                  


Arg Trp Gly Leu Leu Leu Ala Leu Leu Pro Pro Gly Ala Ala Ser Thr 
65                  70                  75                  80  


Gln Val Cys Thr Gly Thr Asp Met Lys Leu Arg Leu Pro Ala Ser Pro 
                85                  90                  95      


Glu Thr His Leu Asp Met Leu Arg His Leu Tyr Gln Gly Cys Gln Val 
            100                 105                 110         


Val Gln Gly Asn Leu Glu Leu Thr Tyr Leu Pro Thr Asn Ala Ser Leu 
        115                 120                 125             


Ser Phe Leu Gln Asp Ile Gln Glu Val Gln Gly Tyr Val Leu Ile Ala 
    130                 135                 140                 


His Asn Gln Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val Arg 
145                 150                 155                 160 


Gly Thr Gln Leu Phe Glu Asp Asn Tyr Ala Leu Ala Val Leu Asp Asn 
                165                 170                 175     


Gly Asp Pro Leu Asn Asn Thr Thr Pro Val Thr Gly Ala Ser Pro Gly 
            180                 185                 190         


Gly Leu Arg Glu Leu Gln Leu Arg Ser Leu Thr Glu Ile Leu Lys Gly 
        195                 200                 205             


Gly Val Leu Ile Gln Arg Asn Pro Gln Leu Cys Tyr Gln Asp Thr Ile 
    210                 215                 220                 


Leu Trp Lys Asp Ile Phe His Lys Asn Asn Gln Leu Ala Leu Thr Leu 
225                 230                 235                 240 


Ile Asp Thr Asn Arg Ser Arg Ala Cys His Pro Cys Ser Pro Met Cys 
                245                 250                 255     


Lys Gly Ser Arg Cys Trp Gly Glu Ser Ser Glu Asp Cys Gln Ser Leu 
            260                 265                 270         


Thr Arg Thr Val Cys Ala Gly Gly Cys Ala Arg Cys Lys Gly Pro Leu 
        275                 280                 285             


Pro Thr Asp Cys Cys His Glu Gln Cys Ala Ala Gly Cys Thr Gly Pro 
    290                 295                 300                 


Lys His Ser Asp Cys Leu Ala Cys Leu His Phe Asn His Ser Gly Ile 
305                 310                 315                 320 


Cys Glu Leu His Cys Pro Ala Leu Val Thr Tyr Asn Thr Asp Thr Phe 
                325                 330                 335     


Glu Ser Met Pro Asn Pro Glu Gly Arg Tyr Thr Phe Gly Ala Ser Cys 
            340                 345                 350         


Val Thr Ala Cys Pro Tyr Asn Tyr Leu Ser Thr Asp Val Gly Ser Cys 
        355                 360                 365             


Thr Leu Val Cys Pro Leu His Asn Gln Glu Val Thr Ala Glu Asp Gly 
    370                 375                 380                 


Thr Gln Arg Cys Glu Lys Cys Ser Lys Pro Cys Ala Arg Val Cys Tyr 
385                 390                 395                 400 


Gly Leu Gly Met Glu His Leu Arg Glu Val Arg Ala Val Thr Ser Ala 
                405                 410                 415     


Asn Ile Gln Glu Phe Ala Gly Cys Lys Lys Ile Phe Gly Ser Leu Ala 
            420                 425                 430         


Phe Leu Pro Glu Ser Phe Asp Gly Asp Pro Ala Ser Asn Thr Ala Pro 
        435                 440                 445             


Leu Gln Pro Glu Gln Leu Gln Val Phe Glu Thr Leu Glu Glu Ile Thr 
    450                 455                 460                 


Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Asp Ser Leu Pro Asp Leu Ser 
465                 470                 475                 480 


Val Phe Gln Asn Leu Gln Val Ile Arg Gly Arg Ile Leu His Asn Gly 
                485                 490                 495     


Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly Ile Ser Trp Leu Gly Leu 
            500                 505                 510         


Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu Ala Leu Ile His His Asn 
        515                 520                 525             


Thr His Leu Cys Phe Val His Thr Val Pro Trp Asp Gln Leu Phe Arg 
    530                 535                 540                 


Asn Pro His Gln Ala Leu Leu His Thr Ala Asn Arg Pro Glu Asp Glu 
545                 550                 555                 560 


Cys Val Gly Glu Gly Leu Ala Cys His Gln Leu Cys Ala Arg Gly His 
                565                 570                 575     


Cys Trp Gly Pro Gly Pro Thr Gln Cys Val Asn Cys Ser Gln Phe Leu 
            580                 585                 590         


Arg Gly Gln Glu Cys Val Glu Glu Cys Arg Val Leu Gln Gly Leu Pro 
        595                 600                 605             


Arg Glu Tyr Val Asn Ala Arg His Cys Leu Pro Cys His Pro Glu Cys 
    610                 615                 620                 


Gln Pro Gln Asn Gly Ser Val Thr Cys Phe Gly Pro Glu Ala Asp Gln 
625                 630                 635                 640 


Cys Val Ala Cys Ala His Tyr Lys Asp Pro Pro Phe Cys Val Ala Arg 
                645                 650                 655     


Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Tyr Met Pro Ile Trp Lys 
            660                 665                 670         


Phe Pro Asp Glu Glu Gly Ala Cys Gln Pro Cys Pro Ile Asn Cys Thr 
        675                 680                 685             


His Ser Cys Val Asp Leu Asp Asp Lys Gly Cys Pro Ala Glu Gln Arg 
    690                 695                 700                 


Ala Ser Pro Leu Thr Ser Ile Ile Ser Ala Val Val Gly Ile Leu Leu 
705                 710                 715                 720 


Val Val Val Leu Gly Val Val Phe Gly Ile Leu Ile Lys Arg Arg Gln 
                725                 730                 735     


Gln Lys Ile Arg Lys Tyr Thr Met Arg Arg Leu Leu Gln Glu Thr Glu 
            740                 745                 750         


Leu Val Glu Pro Leu Thr Pro Ser Gly Ala Met Pro Asn Gln Ala Gln 
        755                 760                 765             


Met Arg Ile Leu Lys Glu Thr Glu Leu Arg Lys Val Lys Val Leu Gly 
    770                 775                 780                 


Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile Trp Ile Pro Asp Gly 
785                 790                 795                 800 


Glu Asn Val Lys Ile Pro Val Ala Ile Lys Val Leu Arg Glu Asn Thr 
                805                 810                 815     


Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala 
            820                 825                 830         


Gly Val Gly Ser Pro Tyr Val Ser Arg Leu Leu Gly Ile Cys Leu Thr 
        835                 840                 845             


Ser Thr Val Gln Leu Val Thr Gln Leu Met Pro Tyr Gly Cys Leu Leu 
    850                 855                 860                 


Asp His Val Arg Glu Asn Arg Gly Arg Leu Gly Ser Gln Asp Leu Leu 
865                 870                 875                 880 


Asn Trp Cys Met Gln Ile Ala Lys Gly Met Ser Tyr Leu Glu Asp Val 
                885                 890                 895     


Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Ser 
            900                 905                 910         


Pro Asn His Val Lys Ile Thr Asp Phe Gly Leu Ala Arg Leu Leu Asp 
        915                 920                 925             


Ile Asp Glu Thr Glu Tyr His Ala Asp Gly Gly Lys Val Pro Ile Lys 
    930                 935                 940                 


Trp Met Ala Leu Glu Ser Ile Leu Arg Arg Arg Phe Thr His Gln Ser 
945                 950                 955                 960 


Asp Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly 
                965                 970                 975     


Ala Lys Pro Tyr Asp Gly Ile Pro Ala Arg Glu Ile Pro Asp Leu Leu 
            980                 985                 990         


Glu Lys Gly Glu Arg Leu Pro Gln  Pro Pro Ile Cys Thr  Ile Asp Val 
        995                 1000                 1005             


Tyr Met  Ile Met Val Lys Cys  Trp Met Ile Asp Ser  Glu Cys Arg 
    1010                 1015                 1020             


Pro Arg  Phe Arg Glu Leu Val  Ser Glu Phe Ser Arg  Met Ala Arg 
    1025                 1030                 1035             


Asp Pro  Gln Arg Phe Val Val  Ile Gln Asn Glu Asp  Leu Gly Pro 
    1040                 1045                 1050             


Ala Ser  Pro Leu Asp Ser Thr  Phe Tyr Arg Ser Leu  Leu Glu Asp 
    1055                 1060                 1065             


Asp Asp  Met Gly Asp Leu Val  Asp Ala Glu Glu Tyr  Leu Val Pro 
    1070                 1075                 1080             


Gln Gln  Gly Phe Phe Cys Pro  Asp Pro Ala Pro Gly  Ala Gly Gly 
    1085                 1090                 1095             


Met Val  His His Arg His Arg  Ser Ser Ser Thr Arg  Ser Gly Gly 
    1100                 1105                 1110             


Gly Asp  Leu Thr Leu Gly Leu  Glu Pro Ser Glu Glu  Glu Ala Pro 
    1115                 1120                 1125             


Arg Ser  Pro Leu Ala Pro Ser  Glu Gly Ala Gly Ser  Asp Val Phe 
    1130                 1135                 1140             


Asp Gly  Asp Leu Gly Met Gly  Ala Ala Lys Gly Leu  Gln Ser Leu 
    1145                 1150                 1155             


Pro Thr  His Asp Pro Ser Pro  Leu Gln Arg Tyr Ser  Glu Asp Pro 
    1160                 1165                 1170             


Thr Val  Pro Leu Pro Ser Glu  Thr Asp Gly Tyr Val  Ala Pro Leu 
    1175                 1180                 1185             


Thr Cys  Ser Pro Gln Pro Glu  Tyr Val Asn Gln Pro  Asp Val Arg 
    1190                 1195                 1200             


Pro Gln  Pro Pro Ser Pro Arg  Glu Gly Pro Leu Pro  Ala Ala Arg 
    1205                 1210                 1215             


Pro Ala  Gly Ala Thr Leu Glu  Arg Pro Lys Thr Leu  Ser Pro Gly 
    1220                 1225                 1230             


Lys Asn  Gly Val Val Lys Asp  Val Phe Ala Phe Gly  Gly Ala Val 
    1235                 1240                 1245             


Glu Asn  Pro Glu Tyr Leu Thr  Pro Gln Gly Gly Ala  Ala Pro Gln 
    1250                 1255                 1260             


Pro His  Pro Pro Pro Ala Phe  Ser Pro Ala Phe Asp  Asn Leu Tyr 
    1265                 1270                 1275             


Tyr Trp  Asp Gln Asp Pro Pro  Glu Arg Gly Ala Pro  Pro Ser Thr 
    1280                 1285                 1290             


Phe Lys  Gly Thr Pro Thr Ala  Glu Asn Pro Glu Tyr  Leu Gly Leu 
    1295                 1300                 1305             


Asp Val  Pro Val Thr Arg Arg  Pro Ser Pro Gln Lys  Pro Cys Val 
    1310                 1315                 1320             


Leu Arg  Glu Gln Gly Arg Pro  Asp Phe Cys Trp His  Gln Glu Val 
    1325                 1330                 1335             


Gly Gly  Pro Ser Asp His Phe  Gln Gly Asn Leu Pro  Cys Gln Glu 
    1340                 1345                 1350             


Pro Val  Leu Arg Asn Leu Pro  Ser Cys Leu Ser Ser  Gln Met Ala 
    1355                 1360                 1365             


Gly Arg  Gly Pro Ala Ser Leu  Glu Glu Glu Gln His  Trp Gly Val 
    1370                 1375                 1380             


Phe Val  Asp Ser Glu Ala Leu  Pro Asn Glu Thr Leu  Gly Ser Ser 
    1385                 1390                 1395             


Gly Cys  His Ser Pro Ala Trp  Pro Phe Pro Ser Arg  Ser Trp Val 
    1400                 1405                 1410             


Leu Lys  Ala Leu Gly Lys Leu  Ala Glu Gly Lys Arg  Pro Gly Ser 
    1415                 1420                 1425             


Val Glu  Gln Lys Arg Pro Ile  Gln Arg Leu Ser Leu  Lys Pro Ser 
    1430                 1435                 1440             


Thr Ala  Pro His Glu Glu Gly  Thr Ala Met Val Ser  Val Ser Arg 
    1445                 1450                 1455             


Leu Cys  Thr Glu Cys Phe Ser  Val Phe Leu Leu Phe  Leu Phe Cys 
    1460                 1465                 1470             


Phe Phe  Lys Asp Glu Ile Lys  Thr Gln Gly Glu 
    1475                 1480                 


<210>  38
<211>  4473
<212>  DNA
<213>  Homo sapiens

<400>  38
aaggggaggt aaccctggcc cctttggtcg gggccccggg cagccgcgcg ccccttccca       60

cggggccctt tactgcgccg cgcgcccggc ccccacccct cgcagcaccc cgcgccccgc      120

gccctcccag ccgggtccag ccggagccat ggggccggag ccgcagtgag caccatggag      180

ctggcggcct tgtgccgctg ggggctcctc ctcgccctct tgccccccgg agccgcgagc      240

acccaagtgt gcaccggcac agacatgaag ctgcggctcc ctgccagtcc cgagacccac      300

ctggacatgc tccgccacct ctaccagggc tgccaggtgg tgcagggaaa cctggaactc      360

acctacctgc ccaccaatgc cagcctgtcc ttcctgcagg atatccagga ggtgcagggc      420

tacgtgctca tcgctcacaa ccaagtgagg caggtcccac tgcagaggct gcggattgtg      480

cgaggcaccc agctctttga ggacaactat gccctggccg tgctagacaa tggagacccg      540

ctgaacaata ccacccctgt cacaggggcc tccccaggag gcctgcggga gctgcagctt      600

cgaagcctca cagagatctt gaaaggaggg gtcttgatcc agcggaaccc ccagctctgc      660

taccaggaca cgattttgtg gaaggacatc ttccacaaga acaaccagct ggctctcaca      720

ctgatagaca ccaaccgctc tcgggcctgc cacccctgtt ctccgatgtg taagggctcc      780

cgctgctggg gagagagttc tgaggattgt cagagcctga cgcgcactgt ctgtgccggt      840

ggctgtgccc gctgcaaggg gccactgccc actgactgct gccatgagca gtgtgctgcc      900

ggctgcacgg gccccaagca ctctgactgc ctggcctgcc tccacttcaa ccacagtggc      960

atctgtgagc tgcactgccc agccctggtc acctacaaca cagacacgtt tgagtccatg     1020

cccaatcccg agggccggta tacattcggc gccagctgtg tgactgcctg tccctacaac     1080

tacctttcta cggacgtggg atcctgcacc ctcgtctgcc ccctgcacaa ccaagaggtg     1140

acagcagagg atggaacaca gcggtgtgag aagtgcagca agccctgtgc ccgagtgtgc     1200

tatggtctgg gcatggagca cttgcgagag gtgagggcag ttaccagtgc caatatccag     1260

gagtttgctg gctgcaagaa gatctttggg agcctggcat ttctgccgga gagctttgat     1320

ggggacccag cctccaacac tgccccgctc cagccagagc agctccaagt gtttgagact     1380

ctggaagaga tcacaggtta cctatacatc tcagcatggc cggacagcct gcctgacctc     1440

agcgtcttcc agaacctgca agtaatccgg ggacgaattc tgcacaatgg cgcctactcg     1500

ctgaccctgc aagggctggg catcagctgg ctggggctgc gctcactgag ggaactgggc     1560

agtggactgg ccctcatcca ccataacacc cacctctgct tcgtgcacac ggtgccctgg     1620

gaccagctct ttcggaaccc gcaccaagct ctgctccaca ctgccaaccg gccagaggac     1680

gagtgtgtgg gcgagggcct ggcctgccac cagctgtgcg cccgagggca ctgctggggt     1740

ccagggccca cccagtgtgt caactgcagc cagttccttc ggggccagga gtgcgtggag     1800

gaatgccgag tactgcaggg gctccccagg gagtatgtga atgccaggca ctgtttgccg     1860

tgccaccctg agtgtcagcc ccagaatggc tcagtgacct gttttggacc ggaggctgac     1920

cagtgtgtgg cctgtgccca ctataaggac cctcccttct gcgtggcccg ctgccccagc     1980

ggtgtgaaac ctgacctctc ctacatgccc atctggaagt ttccagatga ggagggcgca     2040

tgccagcctt gccccatcaa ctgcacccac tcctgtgtgg acctggatga caagggctgc     2100

cccgccgagc agagagccag ccctctgacg tccatcatct ctgcggtggt tggcattctg     2160

ctggtcgtgg tcttgggggt ggtctttggg atcctcatca agcgacggca gcagaagatc     2220

cggaagtaca cgatgcggag actgctgcag gaaacggagc tggtggagcc gctgacacct     2280

agcggagcga tgcccaacca ggcgcagatg cggatcctga aagagacgga gctgaggaag     2340

gtgaaggtgc ttggatctgg cgcttttggc acagtctaca agggcatctg gatccctgat     2400

ggggagaatg tgaaaattcc agtggccatc aaagtgttga gggaaaacac atcccccaaa     2460

gccaacaaag aaatcttaga cgaagcatac gtgatggctg gtgtgggctc cccatatgtc     2520

tcccgccttc tgggcatctg cctgacatcc acggtgcagc tggtgacaca gcttatgccc     2580

tatggctgcc tcttagacca tgtccgggaa aaccgcggac gcctgggctc ccaggacctg     2640

ctgaactggt gtatgcagat tgccaagggg atgagctacc tggaggatgt gcggctcgta     2700

cacagggact tggccgctcg gaacgtgctg gtcaagagtc ccaaccatgt caaaattaca     2760

gacttcgggc tggctcggct gctggacatt gacgagacag agtaccatgc agatgggggc     2820

aaggtgccca tcaagtggat ggcgctggag tccattctcc gccggcggtt cacccaccag     2880

agtgatgtgt ggagttatgg tgtgactgtg tgggagctga tgacttttgg ggccaaacct     2940

tacgatggga tcccagcccg ggagatccct gacctgctgg aaaaggggga gcggctgccc     3000

cagcccccca tctgcaccat tgatgtctac atgatcatgg tcaaatgttg gatgattgac     3060

tctgaatgtc ggccaagatt ccgggagttg gtgtctgaat tctcccgcat ggccagggac     3120

ccccagcgct ttgtggtcat ccagaatgag gacttgggcc cagccagtcc cttggacagc     3180

accttctacc gctcactgct ggaggacgat gacatggggg acctggtgga tgctgaggag     3240

tatctggtac cccagcaggg cttcttctgt ccagaccctg ccccgggcgc tgggggcatg     3300

gtccaccaca ggcaccgcag ctcatctacc aggagtggcg gtggggacct gacactaggg     3360

ctggagccct ctgaagagga ggcccccagg tctccactgg caccctccga aggggctggc     3420

tccgatgtat ttgatggtga cctgggaatg ggggcagcca aggggctgca aagcctcccc     3480

acacatgacc ccagccctct acagcggtac agtgaggacc ccacagtacc cctgccctct     3540

gagactgatg gctacgttgc ccccctgacc tgcagccccc agcctgaata tgtgaaccag     3600

ccagatgttc ggccccagcc cccttcgccc cgagagggcc ctctgcctgc tgcccgacct     3660

gctggtgcca ctctggaaag gcccaagact ctctccccag ggaagaatgg ggtcgtcaaa     3720

gacgtttttg cctttggggg tgccgtggag aaccccgagt acttgacacc ccagggagga     3780

gctgcccctc agccccaccc tcctcctgcc ttcagcccag ccttcgacaa cctctattac     3840

tgggaccagg acccaccaga gcggggggct ccacccagca ccttcaaagg gacacctacg     3900

gcagagaacc cagagtacct gggtctggac gtgccagtgt gaaccagaag gccaagtccg     3960

cagaagccct gatgtgtcct cagggagcag ggaaggcctg acttctgctg gcatcaagag     4020

gtgggagggc cctccgacca cttccagggg aacctgccat gccaggaacc tgtcctaagg     4080

aaccttcctt cctgcttgag ttcccagatg gctggaaggg gtccagcctc gttggaagag     4140

gaacagcact ggggagtctt tgtggattct gaggccctgc ccaatgagac tctagggtcc     4200

agtggatgcc acagcccagc ttggcccttt ccttccagat cctgggtact gaaagcctta     4260

gggaagctgg cctgagaggg gaagcggccc taagggagtg tctaagaaca aaagcgaccc     4320

attcagagac tgtccctgaa acctagtact gccccccatg aggaaggaac agcaatggtg     4380

tcagtatcca ggctttgtac agagtgcttt tctgtttagt ttttactttt tttgttttgt     4440

ttttttaaag atgaaataaa gacccagggg gag                                  4473


<210>  39
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Lys Leu Phe Ala Phe Ile Phe Ile Cys Val Lys Ser Cys Ser Leu 
1               5                   10                  15      


Leu Phe Met Leu Asn Gly Asn Pro Arg Pro Glu Gln Leu Asn Lys Ala 
            20                  25                  30          


Ser Glu Phe Thr Gly Leu Met Asp Asn Met Arg Tyr Leu Tyr Asp Asp 
        35                  40                  45              


Lys His Val Ser Glu Thr Asn Ile Lys Ala Gln Glu Lys Phe Leu Gln 
    50                  55                  60                  


His Asp Leu Leu Phe Lys Ile Asn Gly Ser Lys Ile Asp Gly Ser Lys 
65                  70                  75                  80  


Ile Leu Lys Thr Glu Phe Asn Asn Lys Ser Leu Ser Asp Lys Tyr Lys 
                85                  90                  95      


Asn Lys Asn Val Asp Leu Phe Gly Thr Asn Tyr Tyr Asn Gln Cys Tyr 
            100                 105                 110         


Phe Ser Ala Asp Asn Met Glu Leu Asn Asp Gly Arg Leu Ile Glu Lys 
        115                 120                 125             


Thr Cys Met Tyr Gly Gly Val Thr Glu His Asp Gly Asn Gln Ile Asp 
    130                 135                 140                 


Lys Asn Asn Leu Thr Asp Asn Ser His Asn Ile Leu Ile Lys Val Tyr 
145                 150                 155                 160 


Glu Asn Glu Arg Asn Thr Leu Ser Phe Asp Ile Ser Thr Asn Lys Lys 
                165                 170                 175     


Asn Ile Thr Ala Gln Glu Ile Asp Tyr Lys Val Arg Asn Tyr Leu Leu 
            180                 185                 190         


Lys His Lys Asn Leu Tyr Lys Phe Asn Ser Ser Pro Tyr Glu Thr Gly 
        195                 200                 205             


Tyr Ile Lys Phe Ile Glu Gly Asn Gly His Ser Phe Trp Tyr Asp Met 
    210                 215                 220                 


Met Pro Glu Ser Gly Glu Lys Phe Tyr Pro Thr Lys Tyr Leu Leu Ile 
225                 230                 235                 240 


Tyr Asn Asp Asn Lys Thr Val Glu Ser Lys Ser Ile Asn Val Glu Val 
                245                 250                 255     


His Leu Thr Lys Lys 
            260     


<210>  40
<211>  786
<212>  DNA
<213>  Homo sapiens

<400>  40
atgaagttat ttgcttttat cttcatatgt gttaagtctt gcagcttact atttatgtta       60

aatggcaatc ctagaccaga acaattgaat aaagcgagtg aattcactgg tctaatggat      120

aatatgaggt atttgtatga cgataaacac gtatcagaaa caaacattaa agcccaagag      180

aagtttttac aacatgattt attatttaaa ataaatggct ctaaaattga tggttctaaa      240

attttaaaaa cagaatttaa taataaaagc ctttcggata aatacaaaaa taaaaacgta      300

gatttgtttg ggacaaacta ttataatcaa tgctattttt cagcggataa tatggaatta      360

aatgatggta gactaattga aaaaacgtgt atgtatggcg gtgtgaccga gcatgatgga      420

aatcaaatag ataaaaataa tctaactgat aactctcata atatcttaat taaagtatac      480

gaaaacgaaa gaaacacatt atcttttgat atatctacca ataagaaaaa cataacagca      540

caagaaatag attataaagt tagaaactat ttacttaagc ataaaaattt atataaattt      600

aatagttcgc cttatgagac tggctatata aagtttatcg aaggaaatgg tcattctttt      660

tggtatgata tgatgcctga atctggtgaa aaattttatc cgactaaata tttactaatt      720

tataatgata ataagacagt tgagagtaaa tctattaatg tagaagttca tttaaccaaa      780

aaataa                                                                 786


<210>  41
<211>  1517
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr His His  His His His 
    1265                 1270                 1275             


His Met  Ala Val Glu Gly Gly  Met Lys Cys Val Lys  Phe Leu Leu 
    1280                 1285                 1290             


Tyr Val  Leu Leu Leu Ala Phe  Cys Ala Cys Ala Val  Gly Leu Ile 
    1295                 1300                 1305             


Ala Val  Gly Val Gly Ala Gln  Leu Val Leu Ser Gln  Thr Ile Ile 
    1310                 1315                 1320             


Gln Gly  Ala Thr Pro Gly Ser  Leu Leu Pro Val Val  Ile Ile Ala 
    1325                 1330                 1335             


Val Gly  Val Phe Leu Phe Leu  Val Ala Phe Val Gly  Cys Cys Gly 
    1340                 1345                 1350             


Ala Cys  Lys Glu Asn Tyr Cys  Leu Met Ile Thr Phe  Ala Ile Phe 
    1355                 1360                 1365             


Leu Ser  Leu Ile Met Leu Val  Glu Val Ala Ala Ala  Ile Ala Gly 
    1370                 1375                 1380             


Tyr Val  Phe Arg Asp Lys Val  Met Ser Glu Phe Asn  Asn Asn Phe 
    1385                 1390                 1395             


Arg Gln  Gln Met Glu Asn Tyr  Pro Lys Asn Asn His  Thr Ala Ser 
    1400                 1405                 1410             


Ile Leu  Asp Arg Met Gln Ala  Asp Phe Lys Cys Cys  Gly Ala Ala 
    1415                 1420                 1425             


Asn Tyr  Thr Asp Trp Glu Lys  Ile Pro Ser Met Ser  Lys Asn Arg 
    1430                 1435                 1440             


Val Pro  Asp Ser Cys Cys Ile  Asn Val Thr Val Gly  Cys Gly Ile 
    1445                 1450                 1455             


Asn Phe  Asn Glu Lys Ala Ile  His Lys Glu Gly Cys  Val Glu Lys 
    1460                 1465                 1470             


Ile Gly  Gly Trp Leu Arg Lys  Asn Val Leu Val Val  Ala Ala Ala 
    1475                 1480                 1485             


Ala Leu  Gly Ile Ala Phe Val  Glu Val Leu Gly Ile  Val Phe Ala 
    1490                 1495                 1500             


Cys Cys  Leu Val Lys Ser Ile  Arg Ser Gly Tyr Glu  Val Met 
    1505                 1510                 1515         


<210>  42
<211>  4551
<212>  DNA
<213>  Homo sapiens

<400>  42
atgtttgttt ttcttgtttt attgccacta gtctctagtc agtgtgttaa tcttacaacc       60

agaactcaat taccccctgc atacactaat tctttcacac gtggtgttta ttaccctgac      120

aaagttttca gatcctcagt tttacattca actcaggact tgttcttacc tttcttttcc      180

aatgttactt ggttccatgc tatacatgtc tctgggacca atggtactaa gaggtttgat      240

aaccctgtcc taccatttaa tgatggtgtt tattttgctt ccactgagaa gtctaacata      300

ataagaggct ggatttttgg tactacttta gattcgaaga cccagtccct acttattgtt      360

aataacgcta ctaatgttgt tattaaagtc tgtgaatttc aattttgtaa tgatccattt      420

ttgggtgttt attaccacaa aaacaacaaa agttggatgg aaagtgagtt cagagtttat      480

tctagtgcga ataattgcac ttttgaatat gtctctcagc cttttcttat ggaccttgaa      540

ggaaaacagg gtaatttcaa aaatcttagg gaatttgtgt ttaagaatat tgatggttat      600

tttaaaatat attctaagca cacgcctatt aatttagtgc gtgatctccc tcagggtttt      660

tcggctttag aaccattggt agatttgcca ataggtatta acatcactag gtttcaaact      720

ttacttgctt tacatagaag ttatttgact cctggtgatt cttcttcagg ttggacagct      780

ggtgctgcag cttattatgt gggttatctt caacctagga cttttctatt aaaatataat      840

gaaaatggaa ccattacaga tgctgtagac tgtgcacttg accctctctc agaaacaaag      900

tgtacgttga aatccttcac tgtagaaaaa ggaatctatc aaacttctaa ctttagagtc      960

caaccaacag aatctattgt tagatttcct aatattacaa acttgtgccc ttttggtgaa     1020

gtttttaacg ccaccagatt tgcatctgtt tatgcttgga acaggaagag aatcagcaac     1080

tgtgttgctg attattctgt cctatataat tccgcatcat tttccacttt taagtgttat     1140

ggagtgtctc ctactaaatt aaatgatctc tgctttacta atgtctatgc agattcattt     1200

gtaattagag gtgatgaagt cagacaaatc gctccagggc aaactggaaa gattgctgat     1260

tataattata aattaccaga tgattttaca ggctgcgtta tagcttggaa ttctaacaat     1320

cttgattcta aggttggtgg taattataat tacctgtata gattgtttag gaagtctaat     1380

ctcaaacctt ttgagagaga tatttcaact gaaatctatc aggccggtag cacaccttgt     1440

aatggtgttg aaggttttaa ttgttacttt cctttacaat catatggttt ccaacccact     1500

aatggtgttg gttaccaacc atacagagta gtagtacttt cttttgaact tctacatgca     1560

ccagcaactg tttgtggacc taaaaagtct actaatttgg ttaaaaacaa atgtgtcaat     1620

ttcaacttca atggtttaac aggcacaggt gttcttactg agtctaacaa aaagtttctg     1680

cctttccaac aatttggcag agacattgct gacactactg atgctgtccg tgatccacag     1740

acacttgaga ttcttgacat tacaccatgt tcttttggtg gtgtcagtgt tataacacca     1800

ggaacaaata cttctaacca ggttgctgtt ctttatcagg atgttaactg cacagaagtc     1860

cctgttgcta ttcatgcaga tcaacttact cctacttggc gtgtttattc tacaggttct     1920

aatgtttttc aaacacgtgc aggctgttta ataggggctg aacatgtcaa caactcatat     1980

gagtgtgaca tacccattgg tgcaggtata tgcgctagtt atcagactca gactaattct     2040

cctcggcggg cacgtagtgt agctagtcaa tccatcattg cctacactat gtcacttggt     2100

gcagaaaatt cagttgctta ctctaataac tctattgcca tacccacaaa ttttactatt     2160

agtgttacca cagaaattct accagtgtct atgaccaaga catcagtaga ttgtacaatg     2220

tacatttgtg gtgattcaac tgaatgcagc aatcttttgt tgcaatatgg cagtttttgt     2280

acacaattaa accgtgcttt aactggaata gctgttgaac aagacaaaaa cacccaagaa     2340

gtttttgcac aagtcaaaca aatttacaaa acaccaccaa ttaaagattt tggtggtttt     2400

aatttttcac aaatattacc agatccatca aaaccaagca agaggtcatt tattgaagat     2460

ctacttttca acaaagtgac acttgcagat gctggcttca tcaaacaata tggtgattgc     2520

cttggtgata ttgctgctag agacctcatt tgtgcacaaa agtttaacgg ccttactgtt     2580

ttgccacctt tgctcacaga tgaaatgatt gctcaataca cttctgcact gttagcgggt     2640

acaatcactt ctggttggac ctttggtgca ggtgctgcat tacaaatacc atttgctatg     2700

caaatggctt ataggtttaa tggtattgga gttacacaga atgttctcta tgagaaccaa     2760

aaattgattg ccaaccaatt taatagtgct attggcaaaa ttcaagactc actttcttcc     2820

acagcaagtg cacttggaaa acttcaagat gtggtcaacc aaaatgcaca agctttaaac     2880

acgcttgtta aacaacttag ctccaatttt ggtgcaattt caagtgtttt aaatgatatc     2940

ctttcacgtc ttgacaaagt tgaggctgaa gtgcaaattg ataggttgat cacaggcaga     3000

cttcaaagtt tgcagacata tgtgactcaa caattaatta gagctgcaga aatcagagct     3060

tctgctaatc ttgctgctac taaaatgtca gagtgtgtac ttggacaatc aaaaagagtt     3120

gatttttgtg gaaagggcta tcatcttatg tccttccctc agtcagcacc tcatggtgta     3180

gtcttcttgc atgtgactta tgtccctgca caagaaaaga acttcacaac tgctcctgcc     3240

atttgtcatg atggaaaagc acactttcct cgtgaaggtg tctttgtttc aaatggcaca     3300

cactggtttg taacacaaag gaatttttat gaaccacaaa tcattactac agacaacaca     3360

tttgtgtctg gtaactgtga tgttgtaata ggaattgtca acaacacagt ttatgatcct     3420

ttgcaacctg aattagactc attcaaggag gagttagata aatattttaa gaatcataca     3480

tcaccagatg ttgatttagg tgacatctct ggcattaatg cttcagttgt aaacattcaa     3540

aaagaaattg accgcctcaa tgaggttgcc aagaatttaa atgaatctct catcgatctc     3600

caagaacttg gaaagtatga gcagtatata aaatggccat ggtacatttg gctaggtttt     3660

atagctggct tgattgccat agtaatggtg acaattatgc tttgctgtat gaccagttgc     3720

tgtagttgtc tcaagggctg ttgttcttgt ggatcctgct gcaaatttga tgaagacgac     3780

tctgagccag tgctcaaagg agtcaaatta cattacaccc accaccacca ccaccacatg     3840

gcggtggaag gaggaatgaa atgtgtgaag ttcttgctct acgtcctcct gctggccttt     3900

tgcgcctgtg cagtgggact gattgccgtg ggtgtcgggg cacagcttgt cctgagtcag     3960

accataatcc agggggctac ccctggctct ctgttgccag tggtcatcat cgcagtgggt     4020

gtcttcctct tcctggtggc ttttgtgggc tgctgcgggg cctgcaagga gaactattgt     4080

cttatgatca cgtttgccat ctttctgtct cttatcatgt tggtggaggt ggccgcagcc     4140

attgctggct atgtgtttag agataaggtg atgtcagagt ttaataacaa cttccggcag     4200

cagatggaga attacccgaa aaacaaccac actgcttcga tcctggacag gatgcaggca     4260

gattttaagt gctgtggggc tgctaactac acagattggg agaaaatccc ttccatgtcg     4320

aagaaccgag tccccgactc ctgctgcatt aatgttactg tgggctgtgg gattaatttc     4380

aacgagaagg cgatccataa ggagggctgt gtggagaaga ttgggggctg gctgaggaaa     4440

aatgtgctgg tggtagctgc agcagccctt ggaattgctt ttgtcgaggt tttgggaatt     4500

gtctttgcct gctgcctcgt gaagagtatc agaagtggct acgaggtgat g              4551


<210>  43
<211>  1952
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  43

Pro Trp Pro Leu Trp Ser Gly Pro Arg Ala Ala Ala Arg Pro Phe Pro 
1               5                   10                  15      


Arg Gly Pro Leu Leu Arg Arg Ala Pro Gly Pro His Pro Ser Gln His 
            20                  25                  30          


Pro Ala Pro Arg Ala Leu Pro Ala Gly Ser Ser Arg Ser His Gly Ala 
        35                  40                  45              


Gly Ala Ala Val Ser Thr Met Glu Leu Ala Ala Leu Cys Arg Trp Gly 
    50                  55                  60                  


Leu Leu Leu Ala Leu Leu Pro Pro Gly Ala Ala Ser Thr Gln Val Cys 
65                  70                  75                  80  


Thr Gly Thr Asp Met Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His 
                85                  90                  95      


Leu Asp Met Leu Arg His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly 
            100                 105                 110         


Asn Leu Glu Leu Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu 
        115                 120                 125             


Gln Asp Ile Gln Glu Val Gln Gly Tyr Val Leu Ile Ala His Asn Gln 
    130                 135                 140                 


Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln 
145                 150                 155                 160 


Leu Phe Glu Asp Asn Tyr Ala Leu Ala Val Leu Asp Asn Gly Asp Pro 
                165                 170                 175     


Leu Asn Asn Thr Thr Pro Val Thr Gly Ala Ser Pro Gly Gly Leu Arg 
            180                 185                 190         


Glu Leu Gln Leu Arg Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu 
        195                 200                 205             


Ile Gln Arg Asn Pro Gln Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys 
    210                 215                 220                 


Asp Ile Phe His Lys Asn Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr 
225                 230                 235                 240 


Asn Arg Ser Arg Ala Cys His Pro Cys Ser Pro Met Cys Lys Gly Ser 
                245                 250                 255     


Arg Cys Trp Gly Glu Ser Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr 
            260                 265                 270         


Val Cys Ala Gly Gly Cys Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp 
        275                 280                 285             


Cys Cys His Glu Gln Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser 
    290                 295                 300                 


Asp Cys Leu Ala Cys Leu His Phe Asn His Ser Gly Ile Cys Glu Leu 
305                 310                 315                 320 


His Cys Pro Ala Leu Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met 
                325                 330                 335     


Pro Asn Pro Glu Gly Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala 
            340                 345                 350         


Cys Pro Tyr Asn Tyr Leu Ser Thr Asp Val Gly Ser Cys Thr Leu Val 
        355                 360                 365             


Cys Pro Leu His Asn Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg 
    370                 375                 380                 


Cys Glu Lys Cys Ser Lys Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly 
385                 390                 395                 400 


Met Glu His Leu Arg Glu Val Arg Ala Val Thr Ser Ala Asn Ile Gln 
                405                 410                 415     


Glu Phe Ala Gly Cys Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro 
            420                 425                 430         


Glu Ser Phe Asp Gly Asp Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro 
        435                 440                 445             


Glu Gln Leu Gln Val Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu 
    450                 455                 460                 


Tyr Ile Ser Ala Trp Pro Asp Ser Leu Pro Asp Leu Ser Val Phe Gln 
465                 470                 475                 480 


Asn Leu Gln Val Ile Arg Gly Arg Ile Leu His Asn Gly Ala Tyr Ser 
                485                 490                 495     


Leu Thr Leu Gln Gly Leu Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu 
            500                 505                 510         


Arg Glu Leu Gly Ser Gly Leu Ala Leu Ile His His Asn Thr His Leu 
        515                 520                 525             


Cys Phe Val His Thr Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His 
    530                 535                 540                 


Gln Ala Leu Leu His Thr Ala Asn Arg Pro Glu Asp Glu Cys Val Gly 
545                 550                 555                 560 


Glu Gly Leu Ala Cys His Gln Leu Cys Ala Arg Gly His Cys Trp Gly 
                565                 570                 575     


Pro Gly Pro Thr Gln Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln 
            580                 585                 590         


Glu Cys Val Glu Glu Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr 
        595                 600                 605             


Val Asn Ala Arg His Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln 
    610                 615                 620                 


Asn Gly Ser Val Thr Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala 
625                 630                 635                 640 


Cys Ala His Tyr Lys Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser 
                645                 650                 655     


Gly Val Lys Pro Asp Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp 
            660                 665                 670         


Glu Glu Gly Ala Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys 
        675                 680                 685             


Val Asp Leu Asp Asp Lys Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro 
    690                 695                 700                 


Leu Thr Ser Ile Ile Ser Ala Val Val Gly Ile Leu Leu Val Val Val 
705                 710                 715                 720 


Leu Gly Val Val Phe Gly Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile 
                725                 730                 735     


Arg Lys Tyr Thr Met Arg Arg Leu Leu Gln Glu Thr Glu Leu Val Glu 
            740                 745                 750         


Pro Leu Thr Pro Ser Gly Ala Met Pro Asn Gln Ala Gln Met Arg Ile 
        755                 760                 765             


Leu Lys Glu Thr Glu Leu Arg Lys Val Lys Val Leu Gly Ser Gly Ala 
    770                 775                 780                 


Phe Gly Thr Val Tyr Lys Gly Ile Trp Ile Pro Asp Gly Glu Asn Val 
785                 790                 795                 800 


Lys Ile Pro Val Ala Ile Lys Val Leu Arg Glu Asn Thr Ser Pro Lys 
                805                 810                 815     


Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Gly Val Gly 
            820                 825                 830         


Ser Pro Tyr Val Ser Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val 
        835                 840                 845             


Gln Leu Val Thr Gln Leu Met Pro Tyr Gly Cys Leu Leu Asp His Val 
    850                 855                 860                 


Arg Glu Asn Arg Gly Arg Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys 
865                 870                 875                 880 


Met Gln Ile Ala Lys Gly Met Ser Tyr Leu Glu Asp Val Arg Leu Val 
                885                 890                 895     


His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Ser Pro Asn His 
            900                 905                 910         


Val Lys Ile Thr Asp Phe Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu 
        915                 920                 925             


Thr Glu Tyr His Ala Asp Gly Gly Lys Val Pro Ile Lys Trp Met Ala 
    930                 935                 940                 


Leu Glu Ser Ile Leu Arg Arg Arg Phe Thr His Gln Ser Asp Val Trp 
945                 950                 955                 960 


Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ala Lys Pro 
                965                 970                 975     


Tyr Asp Gly Ile Pro Ala Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly 
            980                 985                 990         


Glu Arg Leu Pro Gln Pro Pro Ile  Cys Thr Ile Asp Val  Tyr Met Ile 
        995                 1000                 1005             


Met Val  Lys Cys Trp Met Ile  Asp Ser Glu Cys Arg  Pro Arg Phe 
    1010                 1015                 1020             


Arg Glu  Leu Val Ser Glu Phe  Ser Arg Met Ala Arg  Asp Pro Gln 
    1025                 1030                 1035             


Arg Phe  Val Val Ile Gln Asn  Glu Asp Leu Gly Pro  Ala Ser Pro 
    1040                 1045                 1050             


Leu Asp  Ser Thr Phe Tyr Arg  Ser Leu Leu Glu Asp  Asp Asp Met 
    1055                 1060                 1065             


Gly Asp  Leu Val Asp Ala Glu  Glu Tyr Leu Val Pro  Gln Gln Gly 
    1070                 1075                 1080             


Phe Phe  Cys Pro Asp Pro Ala  Pro Gly Ala Gly Gly  Met Val His 
    1085                 1090                 1095             


His Arg  His Arg Ser Ser Ser  Thr Arg Ser Gly Gly  Gly Asp Leu 
    1100                 1105                 1110             


Thr Leu  Gly Leu Glu Pro Ser  Glu Glu Glu Ala Pro  Arg Ser Pro 
    1115                 1120                 1125             


Leu Ala  Pro Ser Glu Gly Ala  Gly Ser Asp Val Phe  Asp Gly Asp 
    1130                 1135                 1140             


Leu Gly  Met Gly Ala Ala Lys  Gly Leu Gln Ser Leu  Pro Thr His 
    1145                 1150                 1155             


Asp Pro  Ser Pro Leu Gln Arg  Tyr Ser Glu Asp Pro  Thr Val Pro 
    1160                 1165                 1170             


Leu Pro  Ser Glu Thr Asp Gly  Tyr Val Ala Pro Leu  Thr Cys Ser 
    1175                 1180                 1185             


Pro Gln  Pro Glu Tyr Val Asn  Gln Pro Asp Val Arg  Pro Gln Pro 
    1190                 1195                 1200             


Pro Ser  Pro Arg Glu Gly Pro  Leu Pro Ala Ala Arg  Pro Ala Gly 
    1205                 1210                 1215             


Ala Thr  Leu Glu Arg Pro Lys  Thr Leu Ser Pro Gly  Lys Asn Gly 
    1220                 1225                 1230             


Val Val  Lys Asp Val Phe Ala  Phe Gly Gly Ala Val  Glu Asn Pro 
    1235                 1240                 1245             


Glu Tyr  Leu Thr Pro Gln Gly  Gly Ala Ala Pro Gln  Pro His Pro 
    1250                 1255                 1260             


Pro Pro  Ala Phe Ser Pro Ala  Phe Asp Asn Leu Tyr  Tyr Trp Asp 
    1265                 1270                 1275             


Gln Asp  Pro Pro Glu Arg Gly  Ala Pro Pro Ser Thr  Phe Lys Gly 
    1280                 1285                 1290             


Thr Pro  Thr Ala Glu Asn Pro  Glu Tyr Leu Gly Leu  Asp Val Pro 
    1295                 1300                 1305             


Val Thr  Arg Arg Pro Ser Pro  Gln Lys Pro Cys Val  Leu Arg Glu 
    1310                 1315                 1320             


Gln Gly  Arg Pro Asp Phe Cys  Trp His Gln Glu Val  Gly Gly Pro 
    1325                 1330                 1335             


Ser Asp  His Phe Gln Gly Asn  Leu Pro Cys Gln Glu  Pro Val Leu 
    1340                 1345                 1350             


Arg Asn  Leu Pro Ser Cys Leu  Ser Ser Gln Met Ala  Gly Arg Gly 
    1355                 1360                 1365             


Pro Ala  Ser Leu Glu Glu Glu  Gln His Trp Gly Val  Phe Val Asp 
    1370                 1375                 1380             


Ser Glu  Ala Leu Pro Asn Glu  Thr Leu Gly Ser Ser  Gly Cys His 
    1385                 1390                 1395             


Ser Pro  Ala Trp Pro Phe Pro  Ser Arg Ser Trp Val  Leu Lys Ala 
    1400                 1405                 1410             


Leu Gly  Lys Leu Ala Glu Gly  Lys Arg Pro Gly Ser  Val Glu Gln 
    1415                 1420                 1425             


Lys Arg  Pro Ile Gln Arg Leu  Ser Leu Lys Pro Ser  Thr Ala Pro 
    1430                 1435                 1440             


His Glu  Glu Gly Thr Ala Met  Val Ser Val Ser Arg  Leu Cys Thr 
    1445                 1450                 1455             


Glu Cys  Phe Ser Val Phe Leu  Leu Phe Leu Phe Cys  Phe Phe Lys 
    1460                 1465                 1470             


Asp Glu  Ile Lys Thr Gln Gly  Glu Asp Tyr Lys Asp  Asp Asp Asp 
    1475                 1480                 1485             


Lys Gly  Gln Arg Ala Ser Ala  Gln Arg Arg Arg Arg  Arg Arg Pro 
    1490                 1495                 1500             


His Arg  Ala Ser Cys Gln Ala  Ser Gly Ala Gln Arg  Pro Thr Arg 
    1505                 1510                 1515             


Pro Arg  Ala Pro Ala Pro Pro  Arg Pro Phe Leu Arg  Ala Pro Ala 
    1520                 1525                 1530             


Pro Arg  Pro Ala Arg Pro Pro  Cys Arg Pro Pro Ala  Arg Pro Arg 
    1535                 1540                 1545             


Ala Gly  Pro Pro Ala Ala Gln  Asp Arg Pro Ala Pro  Arg Arg Pro 
    1550                 1555                 1560             


Pro Ala  Ala Arg Ala Ala Met  Gly Val Glu Gly Cys  Thr Lys Cys 
    1565                 1570                 1575             


Ile Lys  Tyr Leu Leu Phe Val  Phe Asn Phe Val Phe  Trp Leu Ala 
    1580                 1585                 1590             


Gly Gly  Val Ile Leu Gly Val  Ala Leu Trp Leu Arg  His Asp Pro 
    1595                 1600                 1605             


Gln Thr  Thr Asn Leu Leu Tyr  Leu Glu Leu Gly Asp  Lys Pro Ala 
    1610                 1615                 1620             


Pro Asn  Thr Phe Tyr Val Gly  Ile Tyr Ile Leu Ile  Ala Val Gly 
    1625                 1630                 1635             


Ala Val  Met Met Phe Val Gly  Phe Leu Gly Cys Tyr  Gly Ala Ile 
    1640                 1645                 1650             


Gln Glu  Ser Gln Cys Leu Leu  Gly Thr Phe Phe Thr  Cys Leu Val 
    1655                 1660                 1665             


Ile Leu  Phe Ala Cys Glu Val  Ala Ala Gly Ile Trp  Gly Phe Val 
    1670                 1675                 1680             


Asn Lys  Asp Gln Ile Ala Lys  Asp Val Lys Gln Phe  Tyr Asp Gln 
    1685                 1690                 1695             


Ala Leu  Gln Gln Ala Val Val  Asp Asp Asp Ala Asn  Asn Ala Lys 
    1700                 1705                 1710             


Ala Val  Val Lys Thr Phe His  Glu Thr Leu Asp Cys  Cys Gly Ser 
    1715                 1720                 1725             


Ser Thr  Leu Thr Ala Leu Thr  Thr Ser Val Leu Lys  Asn Asn Leu 
    1730                 1735                 1740             


Cys Pro  Ser Gly Ser Asn Ile  Ile Ser Asn Leu Phe  Lys Glu Asp 
    1745                 1750                 1755             


Cys His  Gln Lys Ile Asp Asp  Leu Phe Ser Gly Lys  Leu Tyr Leu 
    1760                 1765                 1770             


Ile Gly  Ile Ala Ala Ile Val  Val Ala Val Ile Met  Ile Phe Glu 
    1775                 1780                 1785             


Met Ile  Leu Ser Met Val Leu  Cys Cys Gly Ile Arg  Asn Ser Ser 
    1790                 1795                 1800             


Val Tyr  Gly Pro Ala Ala Leu  Ala Thr Gly Thr Ser  Ala Val Pro 
    1805                 1810                 1815             


Pro Lys  Pro Gly His Phe Arg  Gly Gly His His Arg  Leu Cys Ile 
    1820                 1825                 1830             


Arg Phe  Arg Tyr Tyr Ser Ala  Thr Arg Ser Leu Phe  Thr Phe Gly 
    1835                 1840                 1845             


Val Leu  Phe Leu Phe Thr Phe  Leu Leu Pro Phe Gln  Gly Arg His 
    1850                 1855                 1860             


Met Val  Ala Cys Met Ser Gly  Asp Gly Pro Gly Ser  Trp Gly Leu 
    1865                 1870                 1875             


Glu Gly  Arg Gly Pro Ser Ala  Leu Gly Ser Gln Gly  Ala Leu Pro 
    1880                 1885                 1890             


Ala Gln  Pro Gly Leu Ser Trp  Glu Pro Leu Ala Gln  Arg Leu Ser 
    1895                 1900                 1905             


Leu Ala  Asn Leu Gly Gly Cys  Val His Pro Ala Arg  Pro Ser Cys 
    1910                 1915                 1920             


Gly Leu  His Ser Ser Pro Cys  Ser Leu Leu Pro Arg  Phe Glu Ser 
    1925                 1930                 1935             


Arg Val  Cys Gly His Ser Leu  Pro Ser Cys Thr Cys  Pro Phe 
    1940                 1945                 1950         


<210>  44
<211>  5979
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  44
aaggggaggt aaccctggcc cctttggtcg gggccccggg cagccgcgcg ccccttccca       60

cggggccctt tactgcgccg cgcgcccggc ccccacccct cgcagcaccc cgcgccccgc      120

gccctcccag ccgggtccag ccggagccat ggggccggag ccgcagtgag caccatggag      180

ctggcggcct tgtgccgctg ggggctcctc ctcgccctct tgccccccgg agccgcgagc      240

acccaagtgt gcaccggcac agacatgaag ctgcggctcc ctgccagtcc cgagacccac      300

ctggacatgc tccgccacct ctaccagggc tgccaggtgg tgcagggaaa cctggaactc      360

acctacctgc ccaccaatgc cagcctgtcc ttcctgcagg atatccagga ggtgcagggc      420

tacgtgctca tcgctcacaa ccaagtgagg caggtcccac tgcagaggct gcggattgtg      480

cgaggcaccc agctctttga ggacaactat gccctggccg tgctagacaa tggagacccg      540

ctgaacaata ccacccctgt cacaggggcc tccccaggag gcctgcggga gctgcagctt      600

cgaagcctca cagagatctt gaaaggaggg gtcttgatcc agcggaaccc ccagctctgc      660

taccaggaca cgattttgtg gaaggacatc ttccacaaga acaaccagct ggctctcaca      720

ctgatagaca ccaaccgctc tcgggcctgc cacccctgtt ctccgatgtg taagggctcc      780

cgctgctggg gagagagttc tgaggattgt cagagcctga cgcgcactgt ctgtgccggt      840

ggctgtgccc gctgcaaggg gccactgccc actgactgct gccatgagca gtgtgctgcc      900

ggctgcacgg gccccaagca ctctgactgc ctggcctgcc tccacttcaa ccacagtggc      960

atctgtgagc tgcactgccc agccctggtc acctacaaca cagacacgtt tgagtccatg     1020

cccaatcccg agggccggta tacattcggc gccagctgtg tgactgcctg tccctacaac     1080

tacctttcta cggacgtggg atcctgcacc ctcgtctgcc ccctgcacaa ccaagaggtg     1140

acagcagagg atggaacaca gcggtgtgag aagtgcagca agccctgtgc ccgagtgtgc     1200

tatggtctgg gcatggagca cttgcgagag gtgagggcag ttaccagtgc caatatccag     1260

gagtttgctg gctgcaagaa gatctttggg agcctggcat ttctgccgga gagctttgat     1320

ggggacccag cctccaacac tgccccgctc cagccagagc agctccaagt gtttgagact     1380

ctggaagaga tcacaggtta cctatacatc tcagcatggc cggacagcct gcctgacctc     1440

agcgtcttcc agaacctgca agtaatccgg ggacgaattc tgcacaatgg cgcctactcg     1500

ctgaccctgc aagggctggg catcagctgg ctggggctgc gctcactgag ggaactgggc     1560

agtggactgg ccctcatcca ccataacacc cacctctgct tcgtgcacac ggtgccctgg     1620

gaccagctct ttcggaaccc gcaccaagct ctgctccaca ctgccaaccg gccagaggac     1680

gagtgtgtgg gcgagggcct ggcctgccac cagctgtgcg cccgagggca ctgctggggt     1740

ccagggccca cccagtgtgt caactgcagc cagttccttc ggggccagga gtgcgtggag     1800

gaatgccgag tactgcaggg gctccccagg gagtatgtga atgccaggca ctgtttgccg     1860

tgccaccctg agtgtcagcc ccagaatggc tcagtgacct gttttggacc ggaggctgac     1920

cagtgtgtgg cctgtgccca ctataaggac cctcccttct gcgtggcccg ctgccccagc     1980

ggtgtgaaac ctgacctctc ctacatgccc atctggaagt ttccagatga ggagggcgca     2040

tgccagcctt gccccatcaa ctgcacccac tcctgtgtgg acctggatga caagggctgc     2100

cccgccgagc agagagccag ccctctgacg tccatcatct ctgcggtggt tggcattctg     2160

ctggtcgtgg tcttgggggt ggtctttggg atcctcatca agcgacggca gcagaagatc     2220

cggaagtaca cgatgcggag actgctgcag gaaacggagc tggtggagcc gctgacacct     2280

agcggagcga tgcccaacca ggcgcagatg cggatcctga aagagacgga gctgaggaag     2340

gtgaaggtgc ttggatctgg cgcttttggc acagtctaca agggcatctg gatccctgat     2400

ggggagaatg tgaaaattcc agtggccatc aaagtgttga gggaaaacac atcccccaaa     2460

gccaacaaag aaatcttaga cgaagcatac gtgatggctg gtgtgggctc cccatatgtc     2520

tcccgccttc tgggcatctg cctgacatcc acggtgcagc tggtgacaca gcttatgccc     2580

tatggctgcc tcttagacca tgtccgggaa aaccgcggac gcctgggctc ccaggacctg     2640

ctgaactggt gtatgcagat tgccaagggg atgagctacc tggaggatgt gcggctcgta     2700

cacagggact tggccgctcg gaacgtgctg gtcaagagtc ccaaccatgt caaaattaca     2760

gacttcgggc tggctcggct gctggacatt gacgagacag agtaccatgc agatgggggc     2820

aaggtgccca tcaagtggat ggcgctggag tccattctcc gccggcggtt cacccaccag     2880

agtgatgtgt ggagttatgg tgtgactgtg tgggagctga tgacttttgg ggccaaacct     2940

tacgatggga tcccagcccg ggagatccct gacctgctgg aaaaggggga gcggctgccc     3000

cagcccccca tctgcaccat tgatgtctac atgatcatgg tcaaatgttg gatgattgac     3060

tctgaatgtc ggccaagatt ccgggagttg gtgtctgaat tctcccgcat ggccagggac     3120

ccccagcgct ttgtggtcat ccagaatgag gacttgggcc cagccagtcc cttggacagc     3180

accttctacc gctcactgct ggaggacgat gacatggggg acctggtgga tgctgaggag     3240

tatctggtac cccagcaggg cttcttctgt ccagaccctg ccccgggcgc tgggggcatg     3300

gtccaccaca ggcaccgcag ctcatctacc aggagtggcg gtggggacct gacactaggg     3360

ctggagccct ctgaagagga ggcccccagg tctccactgg caccctccga aggggctggc     3420

tccgatgtat ttgatggtga cctgggaatg ggggcagcca aggggctgca aagcctcccc     3480

acacatgacc ccagccctct acagcggtac agtgaggacc ccacagtacc cctgccctct     3540

gagactgatg gctacgttgc ccccctgacc tgcagccccc agcctgaata tgtgaaccag     3600

ccagatgttc ggccccagcc cccttcgccc cgagagggcc ctctgcctgc tgcccgacct     3660

gctggtgcca ctctggaaag gcccaagact ctctccccag ggaagaatgg ggtcgtcaaa     3720

gacgtttttg cctttggggg tgccgtggag aaccccgagt acttgacacc ccagggagga     3780

gctgcccctc agccccaccc tcctcctgcc ttcagcccag ccttcgacaa cctctattac     3840

tgggaccagg acccaccaga gcggggggct ccacccagca ccttcaaagg gacacctacg     3900

gcagagaacc cagagtacct gggtctggac gtgccagtgt gaaccagaag gccaagtccg     3960

cagaagccct gatgtgtcct cagggagcag ggaaggcctg acttctgctg gcatcaagag     4020

gtgggagggc cctccgacca cttccagggg aacctgccat gccaggaacc tgtcctaagg     4080

aaccttcctt cctgcttgag ttcccagatg gctggaaggg gtccagcctc gttggaagag     4140

gaacagcact ggggagtctt tgtggattct gaggccctgc ccaatgagac tctagggtcc     4200

agtggatgcc acagcccagc ttggcccttt ccttccagat cctgggtact gaaagcctta     4260

gggaagctgg cctgagaggg gaagcggccc taagggagtg tctaagaaca aaagcgaccc     4320

attcagagac tgtccctgaa acctagtact gccccccatg aggaaggaac agcaatggtg     4380

tcagtatcca ggctttgtac agagtgcttt tctgtttagt ttttactttt tttgttttgt     4440

ttttttaaag atgaaataaa gacccagggg gaggactaca aggacgacga cgacaagggc     4500

cagagagcga gcgcgcaacg gcggcgacgg cggcgacccc accgcgcatc ctgccaggcc     4560

tccggcgccc agcgccccac gcgcccccgc gcccccgcgc ccccgcgccc ctttcttcgc     4620

gcccccgccc ctcggcccgc caggccccct tgccggccac ccgccaggcc ccgcgccggc     4680

ccgcccgccg cccaggaccg gcccgcgccc cgcaggccgc ccgccgcccg cgccgccatg     4740

ggagtggagg gctgcaccaa gtgcatcaag tacctgctct tcgtcttcaa tttcgtcttc     4800

tggctggctg gaggcgtgat cctgggtgtg gccctgtggc tccgccatga cccgcagacc     4860

accaacctcc tgtatctgga gctgggagac aagcccgcgc ccaacacctt ctatgtaggc     4920

atctacatcc tcatcgctgt gggcgctgtc atgatgttcg ttggcttcct gggctgctac     4980

ggggccatcc aggaatccca gtgcctgctg gggacgttct tcacctgcct ggtcatcctg     5040

tttgcctgtg aggtggccgc cggcatctgg ggctttgtca acaaggacca gatcgccaag     5100

gatgtgaagc agttctatga ccaggcccta cagcaggccg tggtggatga tgacgccaac     5160

aacgccaagg ctgtggtgaa gaccttccac gagacgcttg actgctgtgg ctccagcaca     5220

ctgactgctt tgaccacctc agtgctcaag aacaatttgt gtccctcggg cagcaacatc     5280

atcagcaacc tcttcaagga ggactgccac cagaagatcg atgacctctt ctccgggaag     5340

ctgtacctca tcggcattgc tgccatcgtg gtcgctgtga tcatgatctt cgagatgatc     5400

ctgagcatgg tgctgtgctg tggcatccgg aacagctccg tgtactgagg ccccgcagct     5460

ctggccacag ggacctctgc agtgccccct aagtgacccg gacacttccg agggggccat     5520

caccgcctgt gtatataacg tttccggtat tactctgcta cacgtagcct ttttactttt     5580

ggggttttgt ttttgttctg aactttcctg ttaccttttc agggctgacg tcacatgtag     5640

gtggcgtgta tgagtggaga cgggcctggg tcttggggac tggagggcag gggtccttct     5700

gccctggggt cccagggtgc tctgcctgct cagccaggcc tctcctggga gccactcgcc     5760

cagagactca gcttggccaa cttggggggc tgtgtccacc cagcccgccc gtcctgtggg     5820

ctgcacagct caccttgttc cctcctgccc cggttcgaga gccgagtctg tgggcactct     5880

ctgccttcat gcacctgtcc tttctaacac gtcgccttca actgtaatca caacatcctg     5940

actccgtcat ttaataaaga aggaacatca ggcatgcta                            5979


<210>  45
<211>  1028
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  45

Met Lys Leu Phe Ala Phe Ile Phe Ile Cys Val Lys Ser Cys Ser Leu 
1               5                   10                  15      


Leu Phe Met Leu Asn Gly Asn Pro Arg Pro Glu Gln Leu Asn Lys Ala 
            20                  25                  30          


Ser Glu Phe Thr Gly Leu Met Asp Asn Met Arg Tyr Leu Tyr Asp Asp 
        35                  40                  45              


Lys His Val Ser Glu Thr Asn Ile Lys Ala Gln Glu Lys Phe Leu Gln 
    50                  55                  60                  


His Asp Leu Leu Phe Lys Ile Asn Gly Ser Lys Ile Asp Gly Ser Lys 
65                  70                  75                  80  


Ile Leu Lys Thr Glu Phe Asn Asn Lys Ser Leu Ser Asp Lys Tyr Lys 
                85                  90                  95      


Asn Lys Asn Val Asp Leu Phe Gly Thr Asn Tyr Tyr Asn Gln Cys Tyr 
            100                 105                 110         


Phe Ser Ala Asp Asn Met Glu Leu Asn Asp Gly Arg Leu Ile Glu Lys 
        115                 120                 125             


Thr Cys Met Tyr Gly Gly Val Thr Glu His Asp Gly Asn Gln Ile Asp 
    130                 135                 140                 


Lys Asn Asn Leu Thr Asp Asn Ser His Asn Ile Leu Ile Lys Val Tyr 
145                 150                 155                 160 


Glu Asn Glu Arg Asn Thr Leu Ser Phe Asp Ile Ser Thr Asn Lys Lys 
                165                 170                 175     


Asn Ile Thr Ala Gln Glu Ile Asp Tyr Lys Val Arg Asn Tyr Leu Leu 
            180                 185                 190         


Lys His Lys Asn Leu Tyr Lys Phe Asn Ser Ser Pro Tyr Glu Thr Gly 
        195                 200                 205             


Tyr Ile Lys Phe Ile Glu Gly Asn Gly His Ser Phe Trp Tyr Asp Met 
    210                 215                 220                 


Met Pro Glu Ser Gly Glu Lys Phe Tyr Pro Thr Lys Tyr Leu Leu Ile 
225                 230                 235                 240 


Tyr Asn Asp Asn Lys Thr Val Glu Ser Lys Ser Ile Asn Val Glu Val 
                245                 250                 255     


His Leu Thr Lys Lys Arg Ser Arg Arg Ala Ser Trp Ser Gly Ser Thr 
            260                 265                 270         


Ala Thr Arg Ala Thr Thr Ala Trp Pro Arg Trp Ala Arg Ser Ser Arg 
        275                 280                 285             


Arg Thr Pro Ala Ser Arg Pro Trp Ser Thr Pro Thr Ser Trp Arg Arg 
    290                 295                 300                 


Ser Ser Pro Arg Trp Pro Pro Pro Ala Thr Ala Pro Thr Ser Ser Ser 
305                 310                 315                 320 


Gly Pro Thr Thr Gly Ser Ala Ala Thr Pro Arg Ala Ala Cys Trp Pro 
                325                 330                 335     


Arg Ser Pro Pro Thr Arg Pro Ser Arg Thr Ser Cys Thr Pro Ser Pro 
            340                 345                 350         


Gly Thr Pro Gly Thr Thr Ala Ser Ser Pro Thr Pro Ser Pro Trp Arg 
        355                 360                 365             


Pro Ala Ser Thr Thr Arg Thr Cys Cys Pro Thr Pro Pro Arg Pro Gly 
    370                 375                 380                 


Arg Arg Ser Pro Pro Trp Thr Arg Ser Arg Pro Arg Ala Arg Ala Pro 
385                 390                 395                 400 


Cys Ser Thr Cys Arg Ser Pro Thr Ser Pro Gly Pro Ser Pro Pro Thr 
                405                 410                 415     


Ala Ala Thr Pro Ser Ser Thr Arg Thr Ala Ser Thr Thr Ser Arg Thr 
            420                 425                 430         


Trp Ala Trp Thr Thr Pro Ala Pro Arg Pro Ala Pro Ser Trp Trp Thr 
        435                 440                 445             


Ser Glu Gln Ala His Glu Arg Arg His Arg Leu Gln His Arg Arg Gly 
    450                 455                 460                 


Arg Leu Gln Gln Gly Arg Asp Arg His Asp His Gln Arg Pro Leu Gly 
465                 470                 475                 480 


Leu Glu Gln His Arg His Gln Gln Gly Glu Leu Arg Arg Asp Arg Ala 
                485                 490                 495     


Ala His Leu Gln Gly Pro Ala Gln Gln Ala Leu Arg Gly Arg Ala Glu 
            500                 505                 510         


Arg Arg His Gln Arg Arg Gln Pro Gln Gln Gly Ala Gly Gln Gly Val 
        515                 520                 525             


Pro Gly Glu Leu Pro Ala Asp Arg Arg Gly Pro Gly Gly Arg Glu Gln 
    530                 535                 540                 


Gly Gln Ala Pro Gly Arg Arg Gly Pro Glu Glu Leu Arg Gly Gly Ala 
545                 550                 555                 560 


Gly Gln Gly Pro Gln Asp Arg Arg His His Gly Glu Arg Pro Glu Gly 
                565                 570                 575     


Arg Asp His Ala Gln His Pro Pro Asp Glu Arg Leu Leu Val Arg Arg 
            580                 585                 590         


Glu Asp Arg Arg Asp Gln Arg Arg Gln Arg Gln Ala Asp Arg Gly Arg 
        595                 600                 605             


Gly Pro Glu Gly Arg Pro Asp Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    610                 615                 620                 


Gln Gln Gln Gln Gln Pro Gly His Arg Gly Gln Gly Pro Ala Tyr Ser 
625                 630                 635                 640 


Arg Leu His Leu Tyr Pro Ala Pro Gly Pro Ala Ser Pro Ser Cys Ala 
                645                 650                 655     


Arg Pro Pro Val Pro His Pro Phe Gly Pro Gly Val Ser Pro His His 
            660                 665                 670         


Ala Gly Gln Arg Arg His Gln Val His Gln Ile Pro Ala Val Arg Ile 
        675                 680                 685             


Leu His Leu Leu Ala Cys Arg Asp Cys Cys Pro Cys His Trp Thr Met 
    690                 695                 700                 


Ala Pro Ile Arg Leu Ser Asp Gln Glu His Leu Arg Ala Arg Asn Phe 
705                 710                 715                 720 


Gln Leu Leu His Arg Ser Leu Tyr Ser Asp Arg Ser Arg Arg Pro His 
                725                 730                 735     


Asp Ala Gly Gly Leu Pro Gly Leu Leu Arg Gly Cys Ala Gly Val Pro 
            740                 745                 750         


Val His Ala Gly Thr Val Leu Arg Leu Pro Leu Gly Asp Ile Arg His 
        755                 760                 765             


Asn Ser Cys Gly His Leu Gly Ile Phe Pro Gln Gly Gly Asp Gly Ser 
    770                 775                 780                 


Pro Gly Val Leu Gln Gly His Leu Gln Gln Ala Glu Asn Gln Gly Ala 
785                 790                 795                 800 


Pro Ala Gly Asn Ala Glu Ser His Pro Leu Cys Val Glu Leu Leu Trp 
                805                 810                 815     


Phe Gly Trp Gly Arg Gly Thr Val Tyr Leu Arg His Leu Pro Gln Glu 
            820                 825                 830         


Gly Arg Thr Arg Asn Leu His Arg Glu Val Leu Ser Cys His Gln Arg 
        835                 840                 845             


Gly Leu Arg Gln Ile Pro His His Arg Arg Ser Gly His Arg His Cys 
    850                 855                 860                 


Arg Gly His Asp Ile Trp His Asp Leu Gln Tyr Asp Leu Val Leu Cys 
865                 870                 875                 880 


Tyr Pro Gln Glu Pro Arg Asp Gly Leu Glu Ser Ala Tyr Ile Pro Glu 
                885                 890                 895     


Gln Glu Ser Leu Pro Met Lys Ile Gly Gly Ile Phe Cys Leu Phe Val 
            900                 905                 910         


Leu Phe Cys Leu Leu Phe Val Val Cys Phe Phe Ala Thr Asn Phe Ser 
        915                 920                 925             


Ile His Ser Ala Leu Leu Asp Lys Ser Ser Tyr Phe Met Phe Val Phe 
    930                 935                 940                 


Cys Phe Ile Gln Tyr His Leu Leu Ser Gly Gly Phe Gly Leu Leu Trp 
945                 950                 955                 960 


Phe Ile Phe Phe Gln Leu Phe Val Phe Ala Cys Tyr Ile Lys Gln Lys 
                965                 970                 975     


Ser Cys Asn Glu Arg Tyr Tyr Ile Cys Thr Leu Asp Lys Ile Leu Tyr 
            980                 985                 990         


Ile Lys Glu Phe Phe Cys Leu Ile  Asp Thr Asn Val Tyr  Gln Leu Ser 
        995                 1000                 1005             


Ser Cys  Asn Leu Tyr Arg Gln  Phe Asp Thr Lys Ile  Met Thr Met 
    1010                 1015                 1020             


Ser Lys  Lys Lys Lys 
    1025             


<210>  46
<211>  3191
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  46
atgaagttat ttgcttttat cttcatatgt gttaagtctt gcagcttact atttatgtta       60

aatggcaatc ctagaccaga acaattgaat aaagcgagtg aattcactgg tctaatggat      120

aatatgaggt atttgtatga cgataaacac gtatcagaaa caaacattaa agcccaagag      180

aagtttttac aacatgattt attatttaaa ataaatggct ctaaaattga tggttctaaa      240

attttaaaaa cagaatttaa taataaaagc ctttcggata aatacaaaaa taaaaacgta      300

gatttgtttg ggacaaacta ttataatcaa tgctattttt cagcggataa tatggaatta      360

aatgatggta gactaattga aaaaacgtgt atgtatggcg gtgtgaccga gcatgatgga      420

aatcaaatag ataaaaataa tctaactgat aactctcata atatcttaat taaagtatac      480

gaaaacgaaa gaaacacatt atcttttgat atatctacca ataagaaaaa cataacagca      540

caagaaatag attataaagt tagaaactat ttacttaagc ataaaaattt atataaattt      600

aatagttcgc cttatgagac tggctatata aagtttatcg aaggaaatgg tcattctttt      660

tggtatgata tgatgcctga atctggtgaa aaattttatc cgactaaata tttactaatt      720

tataatgata ataagacagt tgagagtaaa tctattaatg tagaagttca tttaaccaaa      780

aaataatgaa gatcgaggag ggcaagctgg tgatctggat caacggcgac aagggctaca      840

acggcctggc cgaggtgggc aagaagttcg agaaggacac cggcatcaag gtgaccgtgg      900

agcaccccga caagctggag gagaagttcc cccaggtggc cgccaccggc gacggccccg      960

acatcatctt ctgggcccac gacaggttcg gcggctacgc ccagagcggc ctgctggccg     1020

agatcacccc cgacaaggcc ttccaggaca agctgtaccc cttcacctgg gacgccgtga     1080

ggtacaacgg caagctgatc gcctacccca tcgccgtgga ggccctgagc ctgatctaca     1140

acaaggacct gctgcccaac ccccccaaga cctgggagga gatccccgcc ctggacaagg     1200

agctgaaggc caagggcaag agcgccctga tgttcaacct gcaggagccc tacttcacct     1260

ggcccctgat cgccgccgac ggcggctacg ccttcaagta cgagaacggc aagtacgaca     1320

tcaaggacgt gggcgtggac aacgccggcg ccaaggccgg cctgaccttc ctggtggacc     1380

tgatcagaac aagcacatga acgccgacac cgactacagc atcgccgagg ccgccttcaa     1440

caagggcgag accgccatga ccatcaacgg cccctgggcc tggagcaaca tcgacaccag     1500

caaggtgaac tacggcgtga ccgtgctgcc caccttcaag ggccagccca gcaagccctt     1560

cgtgggcgtg ctgagcgccg gcatcaacgc cgccagcccc aacaaggagc tggccaagga     1620

gttcctggag aactacctgc tgaccgacga gggcctggag gccgtgaaca aggacaagcc     1680

cctgggcgcc gtggccctga agagctacga ggaggagctg gccaaggacc ccaggatcgc     1740

cgccaccatg gagaacgccc agaagggcga gatcatgccc aacatccccc agatgagcgc     1800

cttctggtac gccgtgagga ccgccgtgat caacgccgcc agcggcaggc agaccgtgga     1860

cgaggccctg aaggacgccc agaccaacag cagcagcaac aacaacaaca acaacaacaa     1920

caacaacctg ggcatcgagg gcagggacca gcctacagcc gcctgcatct gtatccagcg     1980

ccaggtcccg ccagtcccag ctgcgcgcgc cccccagtcc cgcacccgtt cggcccaggc     2040

taagttagcc ctcaccatgc cggtcaaagg aggcaccaag tgcatcaaat acctgctgtt     2100

cggatttaac ttcatcttct ggcttgccgg gattgctgtc cttgccattg gactatggct     2160

ccgattcgac tctcagacca agagcatctt cgagcaagaa actaataata ataattccag     2220

cttctacaca ggagtctata ttctgatcgg agccggcgcc ctcatgatgc tggtgggctt     2280

cctgggctgc tgcggggctg tgcaggagtc ccagtgcatg ctgggactgt tcttcggctt     2340

cctcttggtg atattcgcca ttgaaatagc tgcggccatc tggggatatt cccacaagga     2400

tgaggtgatt aaggaagtcc aggagtttta caaggacacc tacaacaagc tgaaaaccaa     2460

ggatgagccc cagcgggaaa cgctgaaagc catccactat gcgttgaact gctgtggttt     2520

ggctgggggc gtggaacagt ttatctcaga catctgcccc aagaaggacg tactcgaaac     2580

cttcaccgtg aagtcctgtc ctgatgccat caaagaggtc ttcgacaata aattccacat     2640

catcggcgca gtgggcatcg gcattgccgt ggtcatgata tttggcatga tcttcagtat     2700

gatcttgtgc tgtgctatcc gcaggaaccg cgagatggtc tagagtcagc ttacatccct     2760

gagcaggaaa gtttacccat gaagattggt gggatttttt gtttgtttgt tttgttttgt     2820

ttgttgtttg ttgtttgttt ttttgccact aattttagta ttcattctgc attgctagat     2880

aaaagctgaa gttactttat gtttgtcttt taatgcttca ttcaatattg acatttgtag     2940

ttgagcgggg ggtttggttt gctttggttt atattttttc agttgtttgt ttttgcttgt     3000

tatattaagc agaaatcctg caatgaaagg tactatattt gctagactct agacaagata     3060

ttgtacataa aagaattttt ttgtctttaa atagatacaa atgtctatca actttaatca     3120

agttgtaact tatattgaag acaatttgat acataataaa aaattatgac aatgtcaaaa     3180

aaaaaaaaaa a                                                          3191


<210>  47
<211>  2484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  47

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr His His  His His His 
    1265                 1270                 1275             


His Met  Ala Val Glu Gly Gly  Met Lys Cys Val Lys  Phe Leu Leu 
    1280                 1285                 1290             


Tyr Val  Leu Leu Leu Ala Phe  Cys Ala Cys Ala Val  Gly Leu Ile 
    1295                 1300                 1305             


Ala Val  Gly Val Gly Ala Gln  Leu Val Leu Ser Gln  Thr Ile Ile 
    1310                 1315                 1320             


Gln Gly  Ala Thr Pro Gly Ser  Leu Leu Pro Val Val  Ile Ile Ala 
    1325                 1330                 1335             


Val Gly  Val Phe Leu Phe Leu  Val Ala Phe Val Gly  Cys Cys Gly 
    1340                 1345                 1350             


Ala Cys  Lys Glu Asn Tyr Cys  Leu Met Ile Thr Phe  Ala Ile Phe 
    1355                 1360                 1365             


Leu Ser  Leu Ile Met Leu Val  Glu Val Ala Ala Ala  Ile Ala Gly 
    1370                 1375                 1380             


Tyr Val  Phe Arg Asp Lys Val  Met Ser Glu Phe Asn  Asn Asn Phe 
    1385                 1390                 1395             


Arg Gln  Gln Met Glu Asn Tyr  Pro Lys Asn Asn His  Thr Ala Ser 
    1400                 1405                 1410             


Ile Leu  Asp Arg Met Gln Ala  Asp Phe Lys Cys Cys  Gly Ala Ala 
    1415                 1420                 1425             


Asn Tyr  Thr Asp Trp Glu Lys  Ile Pro Ser Met Ser  Lys Asn Arg 
    1430                 1435                 1440             


Val Pro  Asp Ser Cys Cys Ile  Asn Val Thr Val Gly  Cys Gly Ile 
    1445                 1450                 1455             


Asn Phe  Asn Glu Lys Ala Ile  His Lys Glu Gly Cys  Val Glu Lys 
    1460                 1465                 1470             


Ile Gly  Gly Trp Leu Arg Lys  Asn Val Leu Val Val  Ala Ala Ala 
    1475                 1480                 1485             


Ala Leu  Gly Ile Ala Phe Val  Glu Val Leu Gly Ile  Val Phe Ala 
    1490                 1495                 1500             


Cys Cys  Leu Val Lys Ser Ile  Arg Ser Gly Tyr Glu  Val Met Glu 
    1505                 1510                 1515             


Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Glu Leu Leu  Cys Tyr Ser 
    1520                 1525                 1530             


Glu Leu  Gln Pro Gln Pro Arg  Tyr Gly Ser Gln Gln  Pro Pro Ala 
    1535                 1540                 1545             


Arg Ala  Ala Arg Thr Pro Gly  Pro Ala Arg Gly Ser  Val Pro Arg 
    1550                 1555                 1560             


Thr Trp  Gln Cys Pro Asp Ile  Cys Val Pro Leu Lys  Ser His Pro 
    1565                 1570                 1575             


Ala Pro  Gly Arg Leu Arg Ala  Gly Asp Met Gln His  Leu Leu Pro 
    1580                 1585                 1590             


Ala Gln  Val Val Gly His Arg  Asp Pro Val Ala Lys  Gly Val Ala 
    1595                 1600                 1605             


Pro Ala  Trp Glu Gln Pro Glu  Gly Val Thr Glu Gln  Cys Ala Arg 
    1610                 1615                 1620             


Arg Pro  Thr Asn Val Leu Phe  Lys Leu Pro Trp Ala  Val Asn Ser 
    1625                 1630                 1635             


Asn Leu  Pro His Arg Val Leu  Asp Ser Arg Thr Gly  Gly Thr Gly 
    1640                 1645                 1650             


Thr Pro  Pro Leu Leu Ala Ala  Ser Gly Gln Glu Pro  Tyr Pro Thr 
    1655                 1660                 1665             


Leu Pro  Gly Gly Gly Trp Gly  Thr Pro Gly Gln Pro  His Arg Gly 
    1670                 1675                 1680             


Ala Ala  Pro Trp Gly Glu Gly  Ala Glu Thr Gly Ala  Ser Cys Gly 
    1685                 1690                 1695             


Gly Ala  Arg Gly His Asp His  Gly Ala Gly Glu Glu  Arg Ser Pro 
    1700                 1705                 1710             


Trp Ser  Gln Phe Leu Val Pro  His Thr Gly Pro Ala  Ala Pro Arg 
    1715                 1720                 1725             


Ala Gly  Ala Val Glu His Leu  Gly Pro Leu Pro Ala  Pro Asp Leu 
    1730                 1735                 1740             


Cys Pro  Ala Ser Asp Ser Pro  Thr Thr Cys Gln Pro  Pro Gly Pro 
    1745                 1750                 1755             


Arg Gly  Gly His Ala Gly Asp  Arg Gly Leu Phe Pro  Gly Arg Ala 
    1760                 1765                 1770             


Val Pro  Ser Leu Gly Gly Pro  Gly Pro Pro Gly Thr  Gly Gly Pro 
    1775                 1780                 1785             


Glu Val  Glu Pro His Ser His  Leu Trp Gln Arg Leu  Leu Leu Gly 
    1790                 1795                 1800             


Gln Gly  Leu Ser Gln Cys Asp  Arg Arg Gly Arg Gly  His Pro Ala 
    1805                 1810                 1815             


Ala Asp  Val Cys Ser Asn Thr  Gly Glu Pro Glu Pro  Gly Asp Thr 
    1820                 1825                 1830             


Ala Asp  Ser Asp His Leu Gln  Leu Ser Gly Ala Gln  Arg Asp Ser 
    1835                 1840                 1845             


Asp Glu  Ala Arg Gly Leu Arg  Arg Asp Arg Gly Asp  Ser Glu Val 
    1850                 1855                 1860             


Gly Pro  Pro Ser Gln Gly Asp  Ala Glu Trp Gly Ser  Ser Pro Ala 
    1865                 1870                 1875             


Thr Gly  Pro Glu Gly Pro Ala  Pro Ala Glu Gly His  Pro Arg Gly 
    1880                 1885                 1890             


Gln Arg  Ala Gln Leu Leu Leu  Leu Cys Asn Pro Gly  Gly Gly Arg 
    1895                 1900                 1905             


Pro Ala  Tyr Thr Gln Glu Pro  Asp Pro Gly Ala Ser  Cys Pro Val 
    1910                 1915                 1920             


Trp Pro  Pro Thr Gly Arg Glu  Gly Leu Ser Gly Lys  Leu Asp Val 
    1925                 1930                 1935             


Ala Arg  Lys Phe Pro Ala Asp  Ser Asn Val Pro Gly  Leu Gly Glu 
    1940                 1945                 1950             


Pro Ile  Ala Arg Ala Gln Val  Ser Lys Gly Trp His  Phe Pro Thr 
    1955                 1960                 1965             


Ala His  Arg Gly Ile Ser Asp  Cys His Ser Arg Ser  Gly His Leu 
    1970                 1975                 1980             


Pro Leu  Ser Gly Gln Glu His  Ser Arg Gly Gly His  Pro Gln Gly 
    1985                 1990                 1995             


Asp Arg  Glu Cys Ala Leu Pro  Pro Val Asp Cys His  His His Cys 
    2000                 2005                 2010             


Gly Ser  Ser Arg Ser His Asn  Gly His Cys Arg Pro  Gln His Val 
    2015                 2020                 2025             


Pro Leu  Pro Pro Ala Glu Asp  Gln Glu Ile Gln Thr  Thr Thr Gly 
    2030                 2035                 2040             


Pro Lys  Arg Asp Pro His Glu  Thr Glu His Thr Ser  His Ala Ser 
    2045                 2050                 2055             


Leu Asn  Leu Ser Arg Asp Arg  Ala Ser Ser Ser Ala  Phe Pro Tyr 
    2060                 2065                 2070             


Trp Trp  Gln Trp Cys His Thr  Glu Gln Ser Gly Arg  His Met Pro 
    2075                 2080                 2085             


Cys Ser  Tyr Thr Tyr Arg Pro  Trp Asp Ala Gly Gly  Gln Gly Ile 
    2090                 2095                 2100             


Val Leu  Ser Gln Ile Gln Gln  His Leu Gly Pro Trp  Tyr Leu His 
    2105                 2110                 2115             


Thr Asn  Thr Arg Pro Arg Ile  Ser Val Val Thr Leu  Ser Gln Glu 
    2120                 2125                 2130             


Glu Gly  Ala Arg Leu Lys Thr  Leu Met Asp Val Lys  Val Pro Asp 
    2135                 2140                 2145             


Glu Arg  Gly Ser Gly Gly Gly  Asp Ile Ala Pro Pro  Gly His Thr 
    2150                 2155                 2160             


Thr Gly  Lys Tyr Asn Leu Leu  Pro Ile Gly Tyr Ala  Glu Ala Pro 
    2165                 2170                 2175             


Gln Thr  Tyr Arg Arg Ser Gly  Pro Pro Thr Cys Val  Ala Ser Lys 
    2180                 2185                 2190             


His Lys  Gly Pro His Phe Leu  Thr Asp Ala Ser Leu  Gly Thr Ala 
    2195                 2200                 2205             


Val Tyr  Pro Gln Pro Leu Met  Ile Cys Ile Tyr Ser  Phe Val Ile 
    2210                 2215                 2220             


Leu Pro  Ala Ile Tyr Val Ser  Phe Met Ala Lys Thr  Val Ser Gly 
    2225                 2230                 2235             


Leu Thr  Glu Leu Pro Val Leu  Ile Thr Phe Lys Val  Thr Arg Tyr 
    2240                 2245                 2250             


Ser Cys  Thr Gly Cys Thr Leu  Gln Glu Ser Ala Trp  Gln Lys Asp 
    2255                 2260                 2265             


Gln Met  Gly Leu Gly Leu Leu  Ile Gly Gln Pro Ala  Phe Pro Gln 
    2270                 2275                 2280             


Lys Glu  Phe Phe Tyr Arg His  Lys Ser Thr Ile Trp  Thr Gly Asn 
    2285                 2290                 2295             


Gly Tyr  Arg Phe Arg Asp Tyr  Pro Val Arg Pro Tyr  Ser Ser Leu 
    2300                 2305                 2310             


Pro Pro  Lys Thr Asp Thr Phe  Val Ser His Leu Pro  Thr His Ile 
    2315                 2320                 2325             


His Phe  Cys Gln Cys Ser Gln  His Ser Ala Val Met  Ser Gly His 
    2330                 2335                 2340             


Glu Cys  Pro Gly Asn Met Pro  Lys Leu Cys Leu Val  Leu Leu Ser 
    2345                 2350                 2355             


Cys Leu  His Phe Thr Gly Ser  Leu His Tyr Ala Ala  Pro Val Ser 
    2360                 2365                 2370             


Cys Ser  Asp Gln Gly Pro Ala  Ser Ser Gly Glu Gly  Gly Gln Gly 
    2375                 2380                 2385             


Ile Gly  Gly Leu Pro Pro Ser  Phe Gly Ser Leu Ile  Arg Val Cys 
    2390                 2395                 2400             


Val Cys  Val Tyr Val Thr Ser  Ser Arg Ser Val Thr  Gln Ala Gly 
    2405                 2410                 2415             


Val Gln  Trp Cys Asn His Gly  Ser Leu Gln Ser Pro  Phe Gly Leu 
    2420                 2425                 2430             


Lys Ser  Ser His Leu Ser Leu  Leu Ser Ser Trp Asp  His Arg Leu 
    2435                 2440                 2445             


Thr Thr  Pro His Leu Ala Asn  Leu Ile Phe Phe Phe  Phe Pro Glu 
    2450                 2455                 2460             


Thr Gly  Ser Arg Asn Ile Ala  Gln Thr Ser Phe Val  Leu Val Asn 
    2465                 2470                 2475             


Lys Ala  Phe Ser Thr Ala 
    2480                 


<210>  48
<211>  7548
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  48
atgtttgttt ttcttgtttt attgccacta gtctctagtc agtgtgttaa tcttacaacc       60

agaactcaat taccccctgc atacactaat tctttcacac gtggtgttta ttaccctgac      120

aaagttttca gatcctcagt tttacattca actcaggact tgttcttacc tttcttttcc      180

aatgttactt ggttccatgc tatacatgtc tctgggacca atggtactaa gaggtttgat      240

aaccctgtcc taccatttaa tgatggtgtt tattttgctt ccactgagaa gtctaacata      300

ataagaggct ggatttttgg tactacttta gattcgaaga cccagtccct acttattgtt      360

aataacgcta ctaatgttgt tattaaagtc tgtgaatttc aattttgtaa tgatccattt      420

ttgggtgttt attaccacaa aaacaacaaa agttggatgg aaagtgagtt cagagtttat      480

tctagtgcga ataattgcac ttttgaatat gtctctcagc cttttcttat ggaccttgaa      540

ggaaaacagg gtaatttcaa aaatcttagg gaatttgtgt ttaagaatat tgatggttat      600

tttaaaatat attctaagca cacgcctatt aatttagtgc gtgatctccc tcagggtttt      660

tcggctttag aaccattggt agatttgcca ataggtatta acatcactag gtttcaaact      720

ttacttgctt tacatagaag ttatttgact cctggtgatt cttcttcagg ttggacagct      780

ggtgctgcag cttattatgt gggttatctt caacctagga cttttctatt aaaatataat      840

gaaaatggaa ccattacaga tgctgtagac tgtgcacttg accctctctc agaaacaaag      900

tgtacgttga aatccttcac tgtagaaaaa ggaatctatc aaacttctaa ctttagagtc      960

caaccaacag aatctattgt tagatttcct aatattacaa acttgtgccc ttttggtgaa     1020

gtttttaacg ccaccagatt tgcatctgtt tatgcttgga acaggaagag aatcagcaac     1080

tgtgttgctg attattctgt cctatataat tccgcatcat tttccacttt taagtgttat     1140

ggagtgtctc ctactaaatt aaatgatctc tgctttacta atgtctatgc agattcattt     1200

gtaattagag gtgatgaagt cagacaaatc gctccagggc aaactggaaa gattgctgat     1260

tataattata aattaccaga tgattttaca ggctgcgtta tagcttggaa ttctaacaat     1320

cttgattcta aggttggtgg taattataat tacctgtata gattgtttag gaagtctaat     1380

ctcaaacctt ttgagagaga tatttcaact gaaatctatc aggccggtag cacaccttgt     1440

aatggtgttg aaggttttaa ttgttacttt cctttacaat catatggttt ccaacccact     1500

aatggtgttg gttaccaacc atacagagta gtagtacttt cttttgaact tctacatgca     1560

ccagcaactg tttgtggacc taaaaagtct actaatttgg ttaaaaacaa atgtgtcaat     1620

ttcaacttca atggtttaac aggcacaggt gttcttactg agtctaacaa aaagtttctg     1680

cctttccaac aatttggcag agacattgct gacactactg atgctgtccg tgatccacag     1740

acacttgaga ttcttgacat tacaccatgt tcttttggtg gtgtcagtgt tataacacca     1800

ggaacaaata cttctaacca ggttgctgtt ctttatcagg atgttaactg cacagaagtc     1860

cctgttgcta ttcatgcaga tcaacttact cctacttggc gtgtttattc tacaggttct     1920

aatgtttttc aaacacgtgc aggctgttta ataggggctg aacatgtcaa caactcatat     1980

gagtgtgaca tacccattgg tgcaggtata tgcgctagtt atcagactca gactaattct     2040

cctcggcggg cacgtagtgt agctagtcaa tccatcattg cctacactat gtcacttggt     2100

gcagaaaatt cagttgctta ctctaataac tctattgcca tacccacaaa ttttactatt     2160

agtgttacca cagaaattct accagtgtct atgaccaaga catcagtaga ttgtacaatg     2220

tacatttgtg gtgattcaac tgaatgcagc aatcttttgt tgcaatatgg cagtttttgt     2280

acacaattaa accgtgcttt aactggaata gctgttgaac aagacaaaaa cacccaagaa     2340

gtttttgcac aagtcaaaca aatttacaaa acaccaccaa ttaaagattt tggtggtttt     2400

aatttttcac aaatattacc agatccatca aaaccaagca agaggtcatt tattgaagat     2460

ctacttttca acaaagtgac acttgcagat gctggcttca tcaaacaata tggtgattgc     2520

cttggtgata ttgctgctag agacctcatt tgtgcacaaa agtttaacgg ccttactgtt     2580

ttgccacctt tgctcacaga tgaaatgatt gctcaataca cttctgcact gttagcgggt     2640

acaatcactt ctggttggac ctttggtgca ggtgctgcat tacaaatacc atttgctatg     2700

caaatggctt ataggtttaa tggtattgga gttacacaga atgttctcta tgagaaccaa     2760

aaattgattg ccaaccaatt taatagtgct attggcaaaa ttcaagactc actttcttcc     2820

acagcaagtg cacttggaaa acttcaagat gtggtcaacc aaaatgcaca agctttaaac     2880

acgcttgtta aacaacttag ctccaatttt ggtgcaattt caagtgtttt aaatgatatc     2940

ctttcacgtc ttgacaaagt tgaggctgaa gtgcaaattg ataggttgat cacaggcaga     3000

cttcaaagtt tgcagacata tgtgactcaa caattaatta gagctgcaga aatcagagct     3060

tctgctaatc ttgctgctac taaaatgtca gagtgtgtac ttggacaatc aaaaagagtt     3120

gatttttgtg gaaagggcta tcatcttatg tccttccctc agtcagcacc tcatggtgta     3180

gtcttcttgc atgtgactta tgtccctgca caagaaaaga acttcacaac tgctcctgcc     3240

atttgtcatg atggaaaagc acactttcct cgtgaaggtg tctttgtttc aaatggcaca     3300

cactggtttg taacacaaag gaatttttat gaaccacaaa tcattactac agacaacaca     3360

tttgtgtctg gtaactgtga tgttgtaata ggaattgtca acaacacagt ttatgatcct     3420

ttgcaacctg aattagactc attcaaggag gagttagata aatattttaa gaatcataca     3480

tcaccagatg ttgatttagg tgacatctct ggcattaatg cttcagttgt aaacattcaa     3540

aaagaaattg accgcctcaa tgaggttgcc aagaatttaa atgaatctct catcgatctc     3600

caagaacttg gaaagtatga gcagtatata aaatggccat ggtacatttg gctaggtttt     3660

atagctggct tgattgccat agtaatggtg acaattatgc tttgctgtat gaccagttgc     3720

tgtagttgtc tcaagggctg ttgttcttgt ggatcctgct gcaaatttga tgaagacgac     3780

tctgagccag tgctcaaagg agtcaaatta cattacaccc accaccacca ccaccacatg     3840

gcggtggaag gaggaatgaa atgtgtgaag ttcttgctct acgtcctcct gctggccttt     3900

tgcgcctgtg cagtgggact gattgccgtg ggtgtcgggg cacagcttgt cctgagtcag     3960

accataatcc agggggctac ccctggctct ctgttgccag tggtcatcat cgcagtgggt     4020

gtcttcctct tcctggtggc ttttgtgggc tgctgcgggg cctgcaagga gaactattgt     4080

cttatgatca cgtttgccat ctttctgtct cttatcatgt tggtggaggt ggccgcagcc     4140

attgctggct atgtgtttag agataaggtg atgtcagagt ttaataacaa cttccggcag     4200

cagatggaga attacccgaa aaacaaccac actgcttcga tcctggacag gatgcaggca     4260

gattttaagt gctgtggggc tgctaactac acagattggg agaaaatccc ttccatgtcg     4320

aagaaccgag tccccgactc ctgctgcatt aatgttactg tgggctgtgg gattaatttc     4380

aacgagaagg cgatccataa ggagggctgt gtggagaaga ttgggggctg gctgaggaaa     4440

aatgtgctgg tggtagctgc agcagccctt ggaattgctt ttgtcgaggt tttgggaatt     4500

gtctttgcct gctgcctcgt gaagagtatc agaagtggct acgaggtgat ggaacaaaaa     4560

ctcatctcag aagaggatct ggagctcctc tgctactcag agttgcaacc tcagcctcgc     4620

tatggctccc agcagccccc ggcccgcgct gcccgcactc ctggtcctgc tcggggctct     4680

gttcccagga cctggcaatg cccagacatc tgtgtccccc tcaaaagtca tcctgccccg     4740

gggaggctcc gtgctggtga catgcagcac ctcctgtgac cagcccaagt tgttgggcat     4800

agagaccccg ttgcctaaaa aggagttgct cctgcctggg aacaaccgga aggtgtatga     4860

actgagcaat gtgcaagaag atagccaacc aatgtgctat tcaaactgcc ctgatgggca     4920

gtcaacagct aaaaccttcc tcaccgtgta ctggactcca gaacgggtgg aactggcacc     4980

cctcccctct tggcagccag tgggcaagaa ccttacccta cgctgccagg tggagggtgg     5040

ggcaccccgg gccaacctca ccgtggtgct gctccgtggg gagaaggagc tgaaacggga     5100

gccagctgtg ggggagcccg ctgaggtcac gaccacggtg ctggtgagga gagatcacca     5160

tggagccaat ttctcgtgcc gcactgaact ggacctgcgg ccccaagggc tggagctgtt     5220

tgagaacacc tcggccccct accagctcca gacctttgtc ctgccagcga ctcccccaca     5280

acttgtcagc ccccgggtcc tagaggtgga cacgcagggg accgtggtct gttccctgga     5340

cgggctgttc ccagtctcgg aggcccaggt ccacctggca ctgggggacc agaggttgaa     5400

ccccacagtc acctatggca acgactcctt ctcggccaag gcctcagtca gtgtgaccgc     5460

agaggacgag ggcacccagc ggctgacgtg tgcagtaata ctggggaacc agagccagga     5520

gacactgcag acagtgacca tctacagctt tccggcgccc aacgtgattc tgacgaagcc     5580

agaggtctca gaagggaccg aggtgacagt gaagtgtgag gcccacccta gagccaaggt     5640

gacgctgaat ggggttccag cccagccact gggcccgagg gcccagctcc tgctgaaggc     5700

caccccagag gacaacgggc gcagcttctc ctgctctgca accctggagg tggccggcca     5760

gcttatacac aagaaccaga cccgggagct tcgtgtcctg tatggccccc gactggacga     5820

gagggattgt ccgggaaact ggacgtggcc agaaaattcc cagcagactc caatgtgcca     5880

ggcttggggg aacccattgc ccgagctcaa gtgtctaaag gatggcactt tcccactgcc     5940

catcggggaa tcagtgactg tcactcgaga tcttgagggc acctacctct gtcgggccag     6000

gagcactcaa ggggaggtca cccgcaaggt gaccgtgaat gtgctctccc cccggtatga     6060

gattgtcatc atcactgtgg tagcagccgc agtcataatg ggcactgcag gcctcagcac     6120

gtacctctat aaccgccagc ggaagatcaa gaaatacaga ctacaacagg cccaaaaagg     6180

gacccccatg aaaccgaaca cacaagccac gcctccctga acctatcccg ggacagggcc     6240

tcttcctcgg ccttcccata ttggtggcag tggtgccaca ctgaacagag tggaagacat     6300

atgccatgca gctacaccta ccggccctgg gacgccggag gacagggcat tgtcctcagt     6360

cagatacaac agcatttggg gccatggtac ctgcacacct aaaacactag gccacgcatc     6420

tgatctgtag tcacatgact aagccaagag gaaggagcaa gactcaagac atgattgatg     6480

gatgttaaag tctagcctga tgagagggga agtggtgggg gagacatagc cccaccatga     6540

ggacatacaa ctgggaaata ctgaaacttg ctgcctattg ggtatgctga ggccccacag     6600

acttacagaa gaagtggccc tccatagaca tgtgtagcat caaaacacaa aggcccacac     6660

ttcctgacgg atgccagctt gggcactgct gtctactgac cccaaccctt gatgatatgt     6720

atttattcat ttgttatttt accagctatt tattgagtgt cttttatgta ggctaaatga     6780

acataggtct ctggcctcac ggagctccca gtcctaatca cattcaaggt caccaggtac     6840

agttgtacag gttgtacact gcaggagagt gcctggcaaa aagatcaaat ggggctggga     6900

cttctcattg gccaacctgc ctttccccag aaggagtgat ttttctatcg gcacaaaagc     6960

actatatgga ctggtaatgg ttacaggttc agagattacc cagtgaggcc ttattcctcc     7020

cttcccccca aaactgacac ctttgttagc cacctcccca cccacataca tttctgccag     7080

tgttcacaat gacactcagc ggtcatgtct ggacatgagt gcccagggaa tatgcccaag     7140

ctatgccttg tcctcttgtc ctgtttgcat ttcactggga gcttgcacta tgcagctcca     7200

gtttcctgca gtgatcaggg tcctgcaagc agtggggaag ggggccaagg tattggagga     7260

ctccctccca gctttggaag cctcatccgc gtgtgtgtgt gtgtgtatgt gtagacaagc     7320

tctcgctctg tcacccaggc tggagtgcag tggtgcaatc atggttcact gcagtcttga     7380

ccttttgggc tcaagtgatc ctcccacctc agcctcctga gtagctggga ccataggctc     7440

acaacaccac acctggcaaa tttgattttt tttttttttc cagagacggg gtctcgcaac     7500

attgcccaga cttcctttgt gttagttaat aaagctttct caactgcc                  7548


<210>  49
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  49

Ile Ser Arg Ala Gly Pro Gly Ser Leu Ala Arg Gly Pro Leu Val Arg 
1               5                   10                  15      


Ala Phe Cys His Gly Val Ser Val Pro Ser Val Ala Ala Val Phe Phe 
            20                  25                  30          


Gly Gly Arg Leu Pro Gly Ser Trp Glu Arg Ala Gly Thr Pro Asp Ala 
        35                  40                  45              


Gly Ala Lys Pro Gln Gly Pro Ser Arg Ala Leu Arg Asp Leu Ser Ala 
    50                  55                  60                  


Leu Leu Gly Ala His Glu Pro Gly Val Arg Gly Cys Ala Ala Gly Glu 
65                  70                  75                  80  


Val Ser Ala Ala Gln Leu Gln Gln Gln Leu Ser Pro Ala Ala Glu Phe 
                85                  90                  95      


Gln Pro Pro His Pro Ala Ala Ala Arg Gln Asp Ala Gln Arg Ala Gly 
            100                 105                 110         


Leu Gly Val Leu Pro Ala Ala Arg Arg Glu Gly Leu Glu Leu Pro Arg 
        115                 120                 125             


Ala Leu Pro Arg Asp Leu Arg Arg Lys Asn Thr Leu Gly His Leu Gln 
    130                 135                 140                 


Asp His Arg Leu Gln Cys Ser Arg Trp Ala Thr Trp Trp Pro Gly Met 
145                 150                 155                 160 


Glu Ala Gly Ser Ser Ile Pro Lys Ala Trp Ser Ala Ser Pro Ala Trp 
                165                 170                 175     


Ile Trp Pro Thr Pro Pro Thr Ser Leu Leu Leu Asp Pro Ala Thr Ser 
            180                 185                 190         


Gly Ser Pro Ser Ala Thr Arg Ala Ser Ile Ser Thr Ala Trp Trp Ser 
        195                 200                 205             


Ala Thr Ala Arg His Pro Leu His Cys Ser Leu Gly Ala Pro Arg Pro 
    210                 215                 220                 


Gln Leu Trp Pro Pro Val Pro Ser Leu Pro Leu Gly Ser Ser Ser Leu 
225                 230                 235                 240 


Trp Ala Leu Arg Thr Tyr Ala Ser Ala Leu Ser Pro Arg Arg Lys Gly 
                245                 250                 255     


Gly Cys Ser Met Pro Ala Glu Arg Glu Lys Glu Glu Tyr Glu Thr Ile 
            260                 265                 270         


Trp Gly Asn Gly His Thr Trp Trp Leu Thr Pro Val Ile Pro Ala Leu 
        275                 280                 285             


Trp Glu Ala Glu Ala Gly Glu Ser Leu Glu Pro Arg Ser Ser Arg Pro 
    290                 295                 300                 


Ala Trp Thr Thr Asp Pro Val Tyr Ala Lys Asn Thr Gln Ile Ser Leu 
305                 310                 315                 320 


Val Trp Trp Pro Ala Pro Val Val Pro Ala Thr Arg Glu Ala Glu Leu 
                325                 330                 335     


Gly Gly Ser Phe Glu Pro Lys Ser Arg Leu Gln Ala Leu Ile Val Pro 
            340                 345                 350         


Leu His Ser Ser Leu Gly Asp Arg Ala Arg Pro Cys Leu Gln Lys Asn 
        355                 360                 365             


Lys Asn Lys Asn Lys Tyr Trp Arg Gly Asn Pro Leu Glu Ser Ile Lys 
    370                 375                 380                 


Ala Ser Leu Thr 
385             


<210>  50
<211>  4473
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  50
aaggggaggt aaccctggcc cctttggtcg gggccccggg cagccgcgcg ccccttccca       60

cggggccctt tactgcgccg cgcgcccggc ccccacccct cgcagcaccc cgcgccccgc      120

gccctcccag ccgggtccag ccggagccat ggggccggag ccgcagtgag caccatggag      180

ctggcggcct tgtgccgctg ggggctcctc ctcgccctct tgccccccgg agccgcgagc      240

acccaagtgt gcaccggcac agacatgaag ctgcggctcc ctgccagtcc cgagacccac      300

ctggacatgc tccgccacct ctaccagggc tgccaggtgg tgcagggaaa cctggaactc      360

acctacctgc ccaccaatgc cagcctgtcc ttcctgcagg atatccagga ggtgcagggc      420

tacgtgctca tcgctcacaa ccaagtgagg caggtcccac tgcagaggct gcggattgtg      480

cgaggcaccc agctctttga ggacaactat gccctggccg tgctagacaa tggagacccg      540

ctgaacaata ccacccctgt cacaggggcc tccccaggag gcctgcggga gctgcagctt      600

cgaagcctca cagagatctt gaaaggaggg gtcttgatcc agcggaaccc ccagctctgc      660

taccaggaca cgattttgtg gaaggacatc ttccacaaga acaaccagct ggctctcaca      720

ctgatagaca ccaaccgctc tcgggcctgc cacccctgtt ctccgatgtg taagggctcc      780

cgctgctggg gagagagttc tgaggattgt cagagcctga cgcgcactgt ctgtgccggt      840

ggctgtgccc gctgcaaggg gccactgccc actgactgct gccatgagca gtgtgctgcc      900

ggctgcacgg gccccaagca ctctgactgc ctggcctgcc tccacttcaa ccacagtggc      960

atctgtgagc tgcactgccc agccctggtc acctacaaca cagacacgtt tgagtccatg     1020

cccaatcccg agggccggta tacattcggc gccagctgtg tgactgcctg tccctacaac     1080

tacctttcta cggacgtggg atcctgcacc ctcgtctgcc ccctgcacaa ccaagaggtg     1140

acagcagagg atggaacaca gcggtgtgag aagtgcagca agccctgtgc ccgagtgtgc     1200

tatggtctgg gcatggagca cttgcgagag gtgagggcag ttaccagtgc caatatccag     1260

gagtttgctg gctgcaagaa gatctttggg agcctggcat ttctgccgga gagctttgat     1320

ggggacccag cctccaacac tgccccgctc cagccagagc agctccaagt gtttgagact     1380

ctggaagaga tcacaggtta cctatacatc tcagcatggc cggacagcct gcctgacctc     1440

agcgtcttcc agaacctgca agtaatccgg ggacgaattc tgcacaatgg cgcctactcg     1500

ctgaccctgc aagggctggg catcagctgg ctggggctgc gctcactgag ggaactgggc     1560

agtggactgg ccctcatcca ccataacacc cacctctgct tcgtgcacac ggtgccctgg     1620

gaccagctct ttcggaaccc gcaccaagct ctgctccaca ctgccaaccg gccagaggac     1680

gagtgtgtgg gcgagggcct ggcctgccac cagctgtgcg cccgagggca ctgctggggt     1740

ccagggccca cccagtgtgt caactgcagc cagttccttc ggggccagga gtgcgtggag     1800

gaatgccgag tactgcaggg gctccccagg gagtatgtga atgccaggca ctgtttgccg     1860

tgccaccctg agtgtcagcc ccagaatggc tcagtgacct gttttggacc ggaggctgac     1920

cagtgtgtgg cctgtgccca ctataaggac cctcccttct gcgtggcccg ctgccccagc     1980

ggtgtgaaac ctgacctctc ctacatgccc atctggaagt ttccagatga ggagggcgca     2040

tgccagcctt gccccatcaa ctgcacccac tcctgtgtgg acctggatga caagggctgc     2100

cccgccgagc agagagccag ccctctgacg tccatcatct ctgcggtggt tggcattctg     2160

ctggtcgtgg tcttgggggt ggtctttggg atcctcatca agcgacggca gcagaagatc     2220

cggaagtaca cgatgcggag actgctgcag gaaacggagc tggtggagcc gctgacacct     2280

agcggagcga tgcccaacca ggcgcagatg cggatcctga aagagacgga gctgaggaag     2340

gtgaaggtgc ttggatctgg cgcttttggc acagtctaca agggcatctg gatccctgat     2400

ggggagaatg tgaaaattcc agtggccatc aaagtgttga gggaaaacac atcccccaaa     2460

gccaacaaag aaatcttaga cgaagcatac gtgatggctg gtgtgggctc cccatatgtc     2520

tcccgccttc tgggcatctg cctgacatcc acggtgcagc tggtgacaca gcttatgccc     2580

tatggctgcc tcttagacca tgtccgggaa aaccgcggac gcctgggctc ccaggacctg     2640

ctgaactggt gtatgcagat tgccaagggg atgagctacc tggaggatgt gcggctcgta     2700

cacagggact tggccgctcg gaacgtgctg gtcaagagtc ccaaccatgt caaaattaca     2760

gacttcgggc tggctcggct gctggacatt gacgagacag agtaccatgc agatgggggc     2820

aaggtgccca tcaagtggat ggcgctggag tccattctcc gccggcggtt cacccaccag     2880

agtgatgtgt ggagttatgg tgtgactgtg tgggagctga tgacttttgg ggccaaacct     2940

tacgatggga tcccagcccg ggagatccct gacctgctgg aaaaggggga gcggctgccc     3000

cagcccccca tctgcaccat tgatgtctac atgatcatgg tcaaatgttg gatgattgac     3060

tctgaatgtc ggccaagatt ccgggagttg gtgtctgaat tctcccgcat ggccagggac     3120

ccccagcgct ttgtggtcat ccagaatgag gacttgggcc cagccagtcc cttggacagc     3180

accttctacc gctcactgct ggaggacgat gacatggggg acctggtgga tgctgaggag     3240

tatctggtac cccagcaggg cttcttctgt ccagaccctg ccccgggcgc tgggggcatg     3300

gtccaccaca ggcaccgcag ctcatctacc aggagtggcg gtggggacct gacactaggg     3360

ctggagccct ctgaagagga ggcccccagg tctccactgg caccctccga aggggctggc     3420

tccgatgtat ttgatggtga cctgggaatg ggggcagcca aggggctgca aagcctcccc     3480

acacatgacc ccagccctct acagcggtac agtgaggacc ccacagtacc cctgccctct     3540

gagactgatg gctacgttgc ccccctgacc tgcagccccc agcctgaata tgtgaaccag     3600

ccagatgttc ggccccagcc cccttcgccc cgagagggcc ctctgcctgc tgcccgacct     3660

gctggtgcca ctctggaaag gcccaagact ctctccccag ggaagaatgg ggtcgtcaaa     3720

gacgtttttg cctttggggg tgccgtggag aaccccgagt acttgacacc ccagggagga     3780

gctgcccctc agccccaccc tcctcctgcc ttcagcccag ccttcgacaa cctctattac     3840

tgggaccagg acccaccaga gcggggggct ccacccagca ccttcaaagg gacacctacg     3900

gcagagaacc cagagtacct gggtctggac gtgccagtgt gaaccagaag gccaagtccg     3960

cagaagccct gatgtgtcct cagggagcag ggaaggcctg acttctgctg gcatcaagag     4020

gtgggagggc cctccgacca cttccagggg aacctgccat gccaggaacc tgtcctaagg     4080

aaccttcctt cctgcttgag ttcccagatg gctggaaggg gtccagcctc gttggaagag     4140

gaacagcact ggggagtctt tgtggattct gaggccctgc ccaatgagac tctagggtcc     4200

agtggatgcc acagcccagc ttggcccttt ccttccagat cctgggtact gaaagcctta     4260

gggaagctgg cctgagaggg gaagcggccc taagggagtg tctaagaaca aaagcgaccc     4320

attcagagac tgtccctgaa acctagtact gccccccatg aggaaggaac agcaatggtg     4380

tcagtatcca ggctttgtac agagtgcttt tctgtttagt ttttactttt tttgttttgt     4440

ttttttaaag atgaaataaa gacccagggg gag                                  4473


<210>  51
<211>  1720
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  51

Met Lys Leu Phe Ala Phe Ile Phe Ile Cys Val Lys Ser Cys Ser Leu 
1               5                   10                  15      


Leu Phe Met Leu Asn Gly Asn Pro Arg Pro Glu Gln Leu Asn Lys Ala 
            20                  25                  30          


Ser Glu Phe Thr Gly Leu Met Asp Asn Met Arg Tyr Leu Tyr Asp Asp 
        35                  40                  45              


Lys His Val Ser Glu Thr Asn Ile Lys Ala Gln Glu Lys Phe Leu Gln 
    50                  55                  60                  


His Asp Leu Leu Phe Lys Ile Asn Gly Ser Lys Ile Asp Gly Ser Lys 
65                  70                  75                  80  


Ile Leu Lys Thr Glu Phe Asn Asn Lys Ser Leu Ser Asp Lys Tyr Lys 
                85                  90                  95      


Asn Lys Asn Val Asp Leu Phe Gly Thr Asn Tyr Tyr Asn Gln Cys Tyr 
            100                 105                 110         


Phe Ser Ala Asp Asn Met Glu Leu Asn Asp Gly Arg Leu Ile Glu Lys 
        115                 120                 125             


Thr Cys Met Tyr Gly Gly Val Thr Glu His Asp Gly Asn Gln Ile Asp 
    130                 135                 140                 


Lys Asn Asn Leu Thr Asp Asn Ser His Asn Ile Leu Ile Lys Val Tyr 
145                 150                 155                 160 


Glu Asn Glu Arg Asn Thr Leu Ser Phe Asp Ile Ser Thr Asn Lys Lys 
                165                 170                 175     


Asn Ile Thr Ala Gln Glu Ile Asp Tyr Lys Val Arg Asn Tyr Leu Leu 
            180                 185                 190         


Lys His Lys Asn Leu Tyr Lys Phe Asn Ser Ser Pro Tyr Glu Thr Gly 
        195                 200                 205             


Tyr Ile Lys Phe Ile Glu Gly Asn Gly His Ser Phe Trp Tyr Asp Met 
    210                 215                 220                 


Met Pro Glu Ser Gly Glu Lys Phe Tyr Pro Thr Lys Tyr Leu Leu Ile 
225                 230                 235                 240 


Tyr Asn Asp Asn Lys Thr Val Glu Ser Lys Ser Ile Asn Val Glu Val 
                245                 250                 255     


His Leu Thr Lys Lys Arg Ser Arg Arg Ala Ser Trp Ser Gly Ser Thr 
            260                 265                 270         


Ala Thr Arg Ala Thr Thr Ala Trp Pro Arg Trp Ala Arg Ser Ser Arg 
        275                 280                 285             


Arg Thr Pro Ala Ser Arg Pro Trp Ser Thr Pro Thr Ser Trp Arg Arg 
    290                 295                 300                 


Ser Ser Pro Arg Trp Pro Pro Pro Ala Thr Ala Pro Thr Ser Ser Ser 
305                 310                 315                 320 


Gly Pro Thr Thr Gly Ser Ala Ala Thr Pro Arg Ala Ala Cys Trp Pro 
                325                 330                 335     


Arg Ser Pro Pro Thr Arg Pro Ser Arg Thr Ser Cys Thr Pro Ser Pro 
            340                 345                 350         


Gly Thr Pro Gly Thr Thr Ala Ser Ser Pro Thr Pro Ser Pro Trp Arg 
        355                 360                 365             


Pro Ala Ser Thr Thr Arg Thr Cys Cys Pro Thr Pro Pro Arg Pro Gly 
    370                 375                 380                 


Arg Arg Ser Pro Pro Trp Thr Arg Ser Arg Pro Arg Ala Arg Ala Pro 
385                 390                 395                 400 


Cys Ser Thr Cys Arg Ser Pro Thr Ser Pro Gly Pro Ser Pro Pro Thr 
                405                 410                 415     


Ala Ala Thr Pro Ser Ser Thr Arg Thr Ala Ser Thr Thr Ser Arg Thr 
            420                 425                 430         


Trp Ala Trp Thr Thr Pro Ala Pro Arg Pro Ala Pro Ser Trp Trp Thr 
        435                 440                 445             


Ser Glu Gln Ala His Glu Arg Arg His Arg Leu Gln His Arg Arg Gly 
    450                 455                 460                 


Arg Leu Gln Gln Gly Arg Asp Arg His Asp His Gln Arg Pro Leu Gly 
465                 470                 475                 480 


Leu Glu Gln His Arg His Gln Gln Gly Glu Leu Arg Arg Asp Arg Ala 
                485                 490                 495     


Ala His Leu Gln Gly Pro Ala Gln Gln Ala Leu Arg Gly Arg Ala Glu 
            500                 505                 510         


Arg Arg His Gln Arg Arg Gln Pro Gln Gln Gly Ala Gly Gln Gly Val 
        515                 520                 525             


Pro Gly Glu Leu Pro Ala Asp Arg Arg Gly Pro Gly Gly Arg Glu Gln 
    530                 535                 540                 


Gly Gln Ala Pro Gly Arg Arg Gly Pro Glu Glu Leu Arg Gly Gly Ala 
545                 550                 555                 560 


Gly Gln Gly Pro Gln Asp Arg Arg His His Gly Glu Arg Pro Glu Gly 
                565                 570                 575     


Arg Asp His Ala Gln His Pro Pro Asp Glu Arg Leu Leu Val Arg Arg 
            580                 585                 590         


Glu Asp Arg Arg Asp Gln Arg Arg Gln Arg Gln Ala Asp Arg Gly Arg 
        595                 600                 605             


Gly Pro Glu Gly Arg Pro Asp Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    610                 615                 620                 


Gln Gln Gln Gln Gln Pro Gly His Arg Gly Gln Asp Gln Pro Thr Ala 
625                 630                 635                 640 


Ala Cys Ile Cys Ile Gln Arg Gln Val Pro Pro Val Pro Ala Ala Arg 
                645                 650                 655     


Ala Pro Gln Ser Arg Thr Arg Ser Ala Gln Ala Lys Leu Ala Leu Thr 
            660                 665                 670         


Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly 
        675                 680                 685             


Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly 
    690                 695                 700                 


Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu 
705                 710                 715                 720 


Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile 
                725                 730                 735     


Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly 
            740                 745                 750         


Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu 
        755                 760                 765             


Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser 
    770                 775                 780                 


His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr 
785                 790                 795                 800 


Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys 
                805                 810                 815     


Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu 
            820                 825                 830         


Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe 
        835                 840                 845             


Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys 
    850                 855                 860                 


Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile 
865                 870                 875                 880 


Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn 
                885                 890                 895     


Arg Glu Met Val Ser Gln Leu Thr Ser Leu Ser Arg Lys Val Tyr Pro 
            900                 905                 910         


Arg Leu Val Gly Phe Phe Val Cys Leu Phe Cys Phe Val Cys Cys Leu 
        915                 920                 925             


Leu Phe Val Phe Leu Pro Leu Ile Leu Val Phe Ile Leu His Cys Ile 
    930                 935                 940                 


Lys Ala Glu Val Thr Leu Cys Leu Ser Phe Asn Ala Ser Phe Asn Ile 
945                 950                 955                 960 


Asp Ile Cys Ser Ala Gly Gly Leu Val Cys Phe Gly Leu Tyr Phe Phe 
                965                 970                 975     


Ser Cys Leu Phe Leu Leu Val Ile Leu Ser Arg Asn Pro Ala Met Lys 
            980                 985                 990         


Gly Thr Ile Phe Ala Arg Leu Thr  Arg Tyr Cys Thr Lys  Asn Phe Phe 
        995                 1000                 1005             


Val Phe  Lys Ile Gln Met Ser  Ile Asn Phe Asn Gln  Val Val Thr 
    1010                 1015                 1020             


Tyr Ile  Glu Asp Asn Leu Ile  His Asn Lys Lys Leu  Gln Cys Gln 
    1025                 1030                 1035             


Lys Lys  Lys Lys His His His  His His His Thr Arg  Lys Gln Ala 
    1040                 1045                 1050             


Cys Thr  Gln Thr Arg His His  Ala Ser Pro Arg Pro  Leu Ala Pro 
    1055                 1060                 1065             


Ala Pro  Gly Ser Arg Ile Leu  Gly Phe Leu Leu Lys  Met Gly Phe 
    1070                 1075                 1080             


Ala Pro  Asn Pro Leu Arg Leu  Gly Gly Gly Leu Arg  Leu Asp Pro 
    1085                 1090                 1095             


Leu His  Leu Gln Ser Pro Arg  Trp Pro Gly Lys Leu  His Pro Val 
    1100                 1105                 1110             


Pro Gln  Ser Val Gln Glu His  Leu Glu Val Trp Asp  Lys Thr Leu 
    1115                 1120                 1125             


Lys His  Lys Gly Trp Glu Gly  Ser Phe Ala Glu Lys  Gly Ala Ile 
    1130                 1135                 1140             


Pro Gly  Arg Gln Glu Glu Leu  His Thr Glu Tyr Pro  Pro Gly Ala 
    1145                 1150                 1155             


Pro Gln  Gln Trp Ser Ala Gly  Ala Glu Asp Gly Val  Gln Asp Glu 
    1160                 1165                 1170             


Met Asp  Gly Thr Asn Thr Pro  Gln Cys Leu Lys Ala  Phe Ser Thr 
    1175                 1180                 1185             


Ser Tyr  Pro Ala Pro Ser Arg  Asn Ser Arg Val Pro  Gly Ser His 
    1190                 1195                 1200             


Ser Asp  Leu Leu Ala Glu Phe  Leu Leu Leu Trp Val  Ser Asp Pro 
    1205                 1210                 1215             


Ile Ala  Val Ala Pro Arg Gly  Gly Ser Asn Glu Ala  Gly Cys Cys 
    1220                 1225                 1230             


His Leu  Asp Leu Leu Asp His  Gln Val Cys Leu His  Pro Glu Arg 
    1235                 1240                 1245             


Ala Gln  Val Leu Pro Thr Val  Glu Ser Pro Trp Glu  Asp Cys Asp 
    1250                 1255                 1260             


Leu Pro  Ala Ser Gly Cys Arg  Trp Glu Val Pro Leu  Gln His Gly 
    1265                 1270                 1275             


Ala Ala  Glu Arg Glu Ala Ser  Ser Gln Glu Gly Asp  His Ser Asp 
    1280                 1285                 1290             


Ser Lys  Pro His Ala Asp Ser  Arg Arg Arg His Ser  Asp Pro Phe 
    1295                 1300                 1305             


Leu Leu  Gln Phe Gln Pro Gln  Cys Tyr Pro Val Met  Glu Thr Pro 
    1310                 1315                 1320             


Trp Arg  Leu Gly Gly Ala Ile  Ala Trp Gly Ala Glu  Asp Pro Lys 
    1325                 1330                 1335             


Arg Trp  Leu Gly Gln His Asn  His Arg Leu Arg Ser  Leu Leu Val 
    1340                 1345                 1350             


Leu Val  Gly Leu Pro Cys Arg  Pro Glu Cys Pro Val  Cys Pro Pro 
    1355                 1360                 1365             


Arg Arg  Glu Gly Pro Glu Asn  Gln Ala Pro Phe Arg  Asp Ser Leu 
    1370                 1375                 1380             


Trp Lys  Leu Gly Gln Pro Pro  Met Leu Leu Lys Gln  Pro Pro Gln 
    1385                 1390                 1395             


Arg Ser  Pro Val Leu Leu Gly  Glu Lys Trp Gln Ala  Ser Gly Glu 
    1400                 1405                 1410             


Arg Lys  Pro Ala Glu Phe Leu  His Leu Pro Arg Arg  Cys Trp Glu 
    1415                 1420                 1425             


Leu Gln  Leu Leu Gly Glu Gln  Leu His Arg Thr Asp  Ser Val Gln 
    1430                 1435                 1440             


Gly Leu  Asp Thr Ser Ala Val  Cys Thr Gln Glu Ala  Ala Cys Val 
    1445                 1450                 1455             


His Glu  Pro Gly Gly Pro Ser  Asp Gly Gly Glu Glu  Cys Asn Pro 
    1460                 1465                 1470             


Asp Leu  Glu Arg Arg Gln Pro  Ser Arg Leu Pro Leu  His Leu Val 
    1475                 1480                 1485             


Leu Glu  Pro Lys Pro Pro Leu  Pro Gln Pro Glu Ala  Glu Ile Gly 
    1490                 1495                 1500             


Ala Gly  Glu Gly Pro Ala Leu  Gly Cys Leu Leu Val  Pro Gly Asp 
    1505                 1510                 1515             


Gln Gln  Cys Gly Gln Gly Pro  Phe Ala Ser Gln His  Pro His Arg 
    1520                 1525                 1530             


Leu Leu  Pro Gly Asp His Arg  Gln Ala Ser Gly Cys  Gly Thr Arg 
    1535                 1540                 1545             


Val Leu  Pro Arg His Pro His  Pro Gly Asn Leu Trp  Ala Gln Ala 
    1550                 1555                 1560             


Pro Ala  Thr Leu Glu Glu Asp  Thr Glu Pro Ala Gly  Ala Ser Gly 
    1565                 1570                 1575             


Glu Phe  Gln Arg Pro Glu Leu  Leu Cys Glu Glu Lys  Gly Lys Gly 
    1580                 1585                 1590             


Pro Pro  Leu Arg Pro Pro Leu  Pro Gly Met Leu Gln  Ser Asn Asp 
    1595                 1600                 1605             


Gly Arg  Trp His Leu His His  Pro Ala Leu Ser Arg  Asp Glu His 
    1610                 1615                 1620             


Thr Thr  Asn Trp Arg Cys Arg  Val Leu Arg Asp Ala  Glu Thr Ser 
    1625                 1630                 1635             


Pro Gly  Leu Arg His Gly His  Leu Phe Ser Ile Ala  Gln Ala Pro 
    1640                 1645                 1650             


Ser Gly  His Tyr Glu Asn Val  Ile Pro Asp Phe Pro  Glu Asp Glu 
    1655                 1660                 1665             


Gly Ile  His Tyr Ser Glu Leu  Ile Gln Phe Gly Val  Gly Glu Arg 
    1670                 1675                 1680             


Pro Gln  Ala Gln Glu Asn Val  Asp Tyr Val Ile Leu  Lys His His 
    1685                 1690                 1695             


Trp Met  Gly Cys Ser Arg Gly  Thr Gly Gly Ser Gly  Gly Gln Gly 
    1700                 1705                 1710             


Ser Pro  Arg Val Phe Pro Arg  
    1715                 1720 


<210>  52
<211>  5323
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  52
atgaagttat ttgcttttat cttcatatgt gttaagtctt gcagcttact atttatgtta       60

aatggcaatc ctagaccaga acaattgaat aaagcgagtg aattcactgg tctaatggat      120

aatatgaggt atttgtatga cgataaacac gtatcagaaa caaacattaa agcccaagag      180

aagtttttac aacatgattt attatttaaa ataaatggct ctaaaattga tggttctaaa      240

attttaaaaa cagaatttaa taataaaagc ctttcggata aatacaaaaa taaaaacgta      300

gatttgtttg ggacaaacta ttataatcaa tgctattttt cagcggataa tatggaatta      360

aatgatggta gactaattga aaaaacgtgt atgtatggcg gtgtgaccga gcatgatgga      420

aatcaaatag ataaaaataa tctaactgat aactctcata atatcttaat taaagtatac      480

gaaaacgaaa gaaacacatt atcttttgat atatctacca ataagaaaaa cataacagca      540

caagaaatag attataaagt tagaaactat ttacttaagc ataaaaattt atataaattt      600

aatagttcgc cttatgagac tggctatata aagtttatcg aaggaaatgg tcattctttt      660

tggtatgata tgatgcctga atctggtgaa aaattttatc cgactaaata tttactaatt      720

tataatgata ataagacagt tgagagtaaa tctattaatg tagaagttca tttaaccaaa      780

aaataatgaa gatcgaggag ggcaagctgg tgatctggat caacggcgac aagggctaca      840

acggcctggc cgaggtgggc aagaagttcg agaaggacac cggcatcaag gtgaccgtgg      900

agcaccccga caagctggag gagaagttcc cccaggtggc cgccaccggc gacggccccg      960

acatcatctt ctgggcccac gacaggttcg gcggctacgc ccagagcggc ctgctggccg     1020

agatcacccc cgacaaggcc ttccaggaca agctgtaccc cttcacctgg gacgccgtga     1080

ggtacaacgg caagctgatc gcctacccca tcgccgtgga ggccctgagc ctgatctaca     1140

acaaggacct gctgcccaac ccccccaaga cctgggagga gatccccgcc ctggacaagg     1200

agctgaaggc caagggcaag agcgccctga tgttcaacct gcaggagccc tacttcacct     1260

ggcccctgat cgccgccgac ggcggctacg ccttcaagta cgagaacggc aagtacgaca     1320

tcaaggacgt gggcgtggac aacgccggcg ccaaggccgg cctgaccttc ctggtggacc     1380

tgatcagaac aagcacatga acgccgacac cgactacagc atcgccgagg ccgccttcaa     1440

caagggcgag accgccatga ccatcaacgg cccctgggcc tggagcaaca tcgacaccag     1500

caaggtgaac tacggcgtga ccgtgctgcc caccttcaag ggccagccca gcaagccctt     1560

cgtgggcgtg ctgagcgccg gcatcaacgc cgccagcccc aacaaggagc tggccaagga     1620

gttcctggag aactacctgc tgaccgacga gggcctggag gccgtgaaca aggacaagcc     1680

cctgggcgcc gtggccctga agagctacga ggaggagctg gccaaggacc ccaggatcgc     1740

cgccaccatg gagaacgccc agaagggcga gatcatgccc aacatccccc agatgagcgc     1800

cttctggtac gccgtgagga ccgccgtgat caacgccgcc agcggcaggc agaccgtgga     1860

cgaggccctg aaggacgccc agaccaacag cagcagcaac aacaacaaca acaacaacaa     1920

caacaacctg ggcatcgagg gcaggaccag cctacagccg cctgcatctg tatccagcgc     1980

caggtcccgc cagtcccagc tgcgcgcgcc ccccagtccc gcacccgttc ggcccaggct     2040

aagttagccc tcaccatgcc ggtcaaagga ggcaccaagt gcatcaaata cctgctgttc     2100

ggatttaact tcatcttctg gcttgccggg attgctgtcc ttgccattgg actatggctc     2160

cgattcgact ctcagaccaa gagcatcttc gagcaagaaa ctaataataa taattccagc     2220

ttctacacag gagtctatat tctgatcgga gccggcgccc tcatgatgct ggtgggcttc     2280

ctgggctgct gcggggctgt gcaggagtcc cagtgcatgc tgggactgtt cttcggcttc     2340

ctcttggtga tattcgccat tgaaatagct gcggccatct ggggatattc ccacaaggat     2400

gaggtgatta aggaagtcca ggagttttac aaggacacct acaacaagct gaaaaccaag     2460

gatgagcccc agcgggaaac gctgaaagcc atccactatg cgttgaactg ctgtggtttg     2520

gctgggggcg tggaacagtt tatctcagac atctgcccca agaaggacgt actcgaaacc     2580

ttcaccgtga agtcctgtcc tgatgccatc aaagaggtct tcgacaataa attccacatc     2640

atcggcgcag tgggcatcgg cattgccgtg gtcatgatat ttggcatgat cttcagtatg     2700

atcttgtgct gtgctatccg caggaaccgc gagatggtct agagtcagct tacatccctg     2760

agcaggaaag tttacccatg aagattggtg ggattttttg tttgtttgtt ttgttttgtt     2820

tgttgtttgt tgtttgtttt tttgccacta attttagtat tcattctgca ttgctagata     2880

aaagctgaag ttactttatg tttgtctttt aatgcttcat tcaatattga catttgtagt     2940

tgagcggggg gtttggtttg ctttggttta tattttttca gttgtttgtt tttgcttgtt     3000

atattaagca gaaatcctgc aatgaaaggt actatatttg ctagactcta gacaagatat     3060

tgtacataaa agaatttttt tgtctttaaa tagatacaaa tgtctatcaa ctttaatcaa     3120

gttgtaactt atattgaaga caatttgata cataataaaa aattatgaca atgtcaaaaa     3180

aaaaaaaaac accaccacca ccaccacacg cggaaacagg cttgcaccca gacacgacac     3240

catgcatctc ctcggcccct ggctcctgct cctggttcta gaatacttgg ctttctctga     3300

ctcaagtaaa tgggtttttg agcaccctga aaccctctac gcctgggagg gggcctgcgt     3360

ctggatcccc tgcacctaca gagccctaga tggtgacctg gaaagcttca tcctgttcca     3420

caatcctgag tataacaaga acacctcgaa gtttgatggg acaagactct atgaaagcac     3480

aaaggatggg aaggttcctt ctgagcagaa aagggtgcaa ttcctgggag acaagaataa     3540

gaactgcaca ctgagtatcc acccggtgca cctcaatgac agtggtcagc tggggctgag     3600

gatggagtcc aagactgaga aatggatgga acgaatacac ctcaatgtct ctgaaaggcc     3660

ttttccacct catatccagc tccctccaga aattcaagag tcccaggaag tcactctgac     3720

ctgcttgctg aatttctcct gctatgggta tccgatccaa ttgcagtggc tcctagaggg     3780

ggttccaatg aggcaggctg ctgtcacctc gacctccttg accatcaagt ctgtcttcac     3840

ccggagcgag ctcaagttct ccccacagtg gagtcaccat gggaagattg tgacctgcca     3900

gcttcaggat gcagatggga agttcctctc caatgacacg gtgcagctga acgtgaagca     3960

tcctcccaag aaggtgacca cagtgattca aaaccccatg ccgattcgag aaggagacac     4020

agtgaccctt tcctgtaact acaattccag taaccccagt gttacccggt atgaatggaa     4080

accccatggc gcctgggagg agccatcgct tggggtgctg aagatccaaa acgttggctg     4140

ggacaacaca accatcgcct gcgcagcttg taatagttgg tgctcgtggg cctcccctgt     4200

cgccctgaat gtccagtatg ccccccgaga cgtgagggtc cggaaaatca agcccctttc     4260

cgagattcac tctggaaact cggtcagcct ccaatgtgac ttctcaagca gccaccccaa     4320

agaagtccag ttcttctggg agaaaaatgg caggcttctg gggaaagaaa gccagctgaa     4380

ttttgactcc atctccccag aagatgctgg gagttacagc tgctgggtga acaactccat     4440

aggacagaca gcgtccaagg cctggacact tgaagtgctg tatgcaccca ggaggctgcg     4500

tgtgtccatg agcccggggg accaagtgat ggaggggaag agtgcaaccc tgacctgtga     4560

gagcgacgcc aaccctcccg tctcccacta cacctggttt gactggaata accaaagcct     4620

cccctaccac agccagaagc tgagattgga gccggtgaag gtccagcact cgggtgccta     4680

ctggtgccag gggaccaaca gtgtgggcaa gggccgttcg cctctcagca ccctcaccgt     4740

ctactatagc ccggagacca tcggcaggcg agtggctgtg ggactcgggt cctgcctcgc     4800

catcctcatc ctggcaatct gtgggctcaa gctccagcga cgttggaaga ggacacagag     4860

ccagcagggg cttcaggaga attccagcgg ccagagcttc tttgtgagga ataaaaaggt     4920

tagaagggcc cccctctctg aaggccccca ctccctggga tgctacaatc caatgatgga     4980

agatggcatt agctacacca ccctgcgctt tcccgagatg aacataccac gaactggaga     5040

tgcagagtcc tcagagatgc agagacctcc cccggactgc gatgacacgg tcacttattc     5100

agcattgcac aagcgccaag tgggcactat gagaacgtca ttccagattt tccagaagat     5160

gaggggattc attactcaga gctgatccag tttggggtcg gggagcggcc tcaggcacaa     5220

gaaaatgtgg actatgtgat cctcaaacat tgacactgga tgggctgcag cagaggcact     5280

gggggcagcg ggggccaggg aagtccccga gttttcccca gac                       5323


<210>  53
<211>  1201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  53

Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val 
1               5                   10                  15      


Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly 
            20                  25                  30          


Val Gly Ala Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala Thr 
        35                  40                  45              


Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu 
    50                  55                  60                  


Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr 
65                  70                  75                  80  


Cys Leu Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val 
                85                  90                  95      


Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met 
            100                 105                 110         


Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys 
        115                 120                 125             


Asn Asn His Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys 
    130                 135                 140                 


Cys Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro Ser Met 
145                 150                 155                 160 


Ser Lys Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr Val Gly 
                165                 170                 175     


Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val 
            180                 185                 190         


Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala 
        195                 200                 205             


Ala Ala Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe Ala 
    210                 215                 220                 


Cys Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met His His 
225                 230                 235                 240 


His His His His Glu Leu Leu Cys Tyr Ser Glu Leu Gln Pro Gln Pro 
                245                 250                 255     


Arg Tyr Gly Ser Gln Gln Pro Pro Ala Arg Ala Ala Arg Thr Pro Gly 
            260                 265                 270         


Pro Ala Arg Gly Ser Val Pro Arg Thr Trp Gln Cys Pro Asp Ile Cys 
        275                 280                 285             


Val Pro Leu Lys Ser His Pro Ala Pro Gly Arg Leu Arg Ala Gly Asp 
    290                 295                 300                 


Met Gln His Leu Leu Pro Ala Gln Val Val Gly His Arg Asp Pro Val 
305                 310                 315                 320 


Ala Lys Gly Val Ala Pro Ala Trp Glu Gln Pro Glu Gly Val Thr Glu 
                325                 330                 335     


Gln Cys Ala Arg Arg Pro Thr Asn Val Leu Phe Lys Leu Pro Trp Ala 
            340                 345                 350         


Val Asn Ser Asn Leu Pro His Arg Val Leu Asp Ser Arg Thr Gly Gly 
        355                 360                 365             


Thr Gly Thr Pro Pro Leu Leu Ala Ala Ser Gly Gln Glu Pro Tyr Pro 
    370                 375                 380                 


Thr Leu Pro Gly Gly Gly Trp Gly Thr Pro Gly Gln Pro His Arg Gly 
385                 390                 395                 400 


Ala Ala Pro Trp Gly Glu Gly Ala Glu Thr Gly Ala Ser Cys Gly Gly 
                405                 410                 415     


Ala Arg Gly His Asp His Gly Ala Gly Glu Glu Arg Ser Pro Trp Ser 
            420                 425                 430         


Gln Phe Leu Val Pro His Thr Gly Pro Ala Ala Pro Arg Ala Gly Ala 
        435                 440                 445             


Val Glu His Leu Gly Pro Leu Pro Ala Pro Asp Leu Cys Pro Ala Ser 
    450                 455                 460                 


Asp Ser Pro Thr Thr Cys Gln Pro Pro Gly Pro Arg Gly Gly His Ala 
465                 470                 475                 480 


Gly Asp Arg Gly Leu Phe Pro Gly Arg Ala Val Pro Ser Leu Gly Gly 
                485                 490                 495     


Pro Gly Pro Pro Gly Thr Gly Gly Pro Glu Val Glu Pro His Ser His 
            500                 505                 510         


Leu Trp Gln Arg Leu Leu Leu Gly Gln Gly Leu Ser Gln Cys Asp Arg 
        515                 520                 525             


Arg Gly Arg Gly His Pro Ala Ala Asp Val Cys Ser Asn Thr Gly Glu 
    530                 535                 540                 


Pro Glu Pro Gly Asp Thr Ala Asp Ser Asp His Leu Gln Leu Ser Gly 
545                 550                 555                 560 


Ala Gln Arg Asp Ser Asp Glu Ala Arg Gly Leu Arg Arg Asp Arg Gly 
                565                 570                 575     


Asp Ser Glu Val Gly Pro Pro Ser Gln Gly Asp Ala Glu Trp Gly Ser 
            580                 585                 590         


Ser Pro Ala Thr Gly Pro Glu Gly Pro Ala Pro Ala Glu Gly His Pro 
        595                 600                 605             


Arg Gly Gln Arg Ala Gln Leu Leu Leu Leu Cys Asn Pro Gly Gly Gly 
    610                 615                 620                 


Arg Pro Ala Tyr Thr Gln Glu Pro Asp Pro Gly Ala Ser Cys Pro Val 
625                 630                 635                 640 


Trp Pro Pro Thr Gly Arg Glu Gly Leu Ser Gly Lys Leu Asp Val Ala 
                645                 650                 655     


Arg Lys Phe Pro Ala Asp Ser Asn Val Pro Gly Leu Gly Glu Pro Ile 
            660                 665                 670         


Ala Arg Ala Gln Val Ser Lys Gly Trp His Phe Pro Thr Ala His Arg 
        675                 680                 685             


Gly Ile Ser Asp Cys His Ser Arg Ser Gly His Leu Pro Leu Ser Gly 
    690                 695                 700                 


Gln Glu His Ser Arg Gly Gly His Pro Gln Gly Asp Arg Glu Cys Ala 
705                 710                 715                 720 


Leu Pro Pro Val Asp Cys His His His Cys Gly Ser Ser Arg Ser His 
                725                 730                 735     


Asn Gly His Cys Arg Pro Gln His Val Pro Leu Pro Pro Ala Glu Asp 
            740                 745                 750         


Gln Glu Ile Gln Thr Thr Thr Gly Pro Lys Arg Asp Pro His Glu Thr 
        755                 760                 765             


Glu His Thr Ser His Ala Ser Leu Asn Leu Ser Arg Asp Arg Ala Ser 
    770                 775                 780                 


Ser Ser Ala Phe Pro Tyr Trp Trp Gln Trp Cys His Thr Glu Gln Ser 
785                 790                 795                 800 


Gly Arg His Met Pro Cys Ser Tyr Thr Tyr Arg Pro Trp Asp Ala Gly 
                805                 810                 815     


Gly Gln Gly Ile Val Leu Ser Gln Ile Gln Gln His Leu Gly Pro Trp 
            820                 825                 830         


Tyr Leu His Thr Asn Thr Arg Pro Arg Ile Ser Val Val Thr Leu Ser 
        835                 840                 845             


Gln Glu Glu Gly Ala Arg Leu Lys Thr Leu Met Asp Val Lys Val Pro 
    850                 855                 860                 


Asp Glu Arg Gly Ser Gly Gly Gly Asp Ile Ala Pro Pro Gly His Thr 
865                 870                 875                 880 


Thr Gly Lys Tyr Asn Leu Leu Pro Ile Gly Tyr Ala Glu Ala Pro Gln 
                885                 890                 895     


Thr Tyr Arg Arg Ser Gly Pro Pro Thr Cys Val Ala Ser Lys His Lys 
            900                 905                 910         


Gly Pro His Phe Leu Thr Asp Ala Ser Leu Gly Thr Ala Val Tyr Pro 
        915                 920                 925             


Gln Pro Leu Met Ile Cys Ile Tyr Ser Phe Val Ile Leu Pro Ala Ile 
    930                 935                 940                 


Tyr Val Ser Phe Met Ala Lys Thr Val Ser Gly Leu Thr Glu Leu Pro 
945                 950                 955                 960 


Val Leu Ile Thr Phe Lys Val Thr Arg Tyr Ser Cys Thr Gly Cys Thr 
                965                 970                 975     


Leu Gln Glu Ser Ala Trp Gln Lys Asp Gln Met Gly Leu Gly Leu Leu 
            980                 985                 990         


Ile Gly Gln Pro Ala Phe Pro Gln  Lys Glu Phe Phe Tyr  Arg His Lys 
        995                 1000                 1005             


Ser Thr  Ile Trp Thr Gly Asn  Gly Tyr Arg Phe Arg  Asp Tyr Pro 
    1010                 1015                 1020             


Val Arg  Pro Tyr Ser Ser Leu  Pro Pro Lys Thr Asp  Thr Phe Val 
    1025                 1030                 1035             


Ser His  Leu Pro Thr His Ile  His Phe Cys Gln Cys  Ser Gln His 
    1040                 1045                 1050             


Ser Ala  Val Met Ser Gly His  Glu Cys Pro Gly Asn  Met Pro Lys 
    1055                 1060                 1065             


Leu Cys  Leu Val Leu Leu Ser  Cys Leu His Phe Thr  Gly Ser Leu 
    1070                 1075                 1080             


His Tyr  Ala Ala Pro Val Ser  Cys Ser Asp Gln Gly  Pro Ala Ser 
    1085                 1090                 1095             


Ser Gly  Glu Gly Gly Gln Gly  Ile Gly Gly Leu Pro  Pro Ser Phe 
    1100                 1105                 1110             


Gly Ser  Leu Ile Arg Val Cys  Val Cys Val Tyr Val  Thr Ser Ser 
    1115                 1120                 1125             


Arg Ser  Val Thr Gln Ala Gly  Val Gln Trp Cys Asn  His Gly Ser 
    1130                 1135                 1140             


Leu Gln  Ser Pro Phe Gly Leu  Lys Ser Ser His Leu  Ser Leu Leu 
    1145                 1150                 1155             


Ser Ser  Trp Asp His Arg Leu  Thr Thr Pro His Leu  Ala Asn Leu 
    1160                 1165                 1170             


Ile Phe  Phe Phe Phe Pro Glu  Thr Gly Ser Arg Asn  Ile Ala Gln 
    1175                 1180                 1185             


Thr Ser  Phe Val Leu Val Asn  Lys Ala Phe Ser Thr  Ala 
    1190                 1195                 1200     


<210>  54
<211>  2967
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  54
gagctcctct gctactcaga gttgcaacct cagcctcgct atggctccca gcagcccccg       60

gcccgcgctg cccgcactcc tggtcctgct cggggctctg ttcccaggac ctggcaatgc      120

ccagacatct gtgtccccct caaaagtcat cctgccccgg ggaggctccg tgctggtgac      180

atgcagcacc tcctgtgacc agcccaagtt gttgggcata gagaccccgt tgcctaaaaa      240

ggagttgctc ctgcctggga acaaccggaa ggtgtatgaa ctgagcaatg tgcaagaaga      300

tagccaacca atgtgctatt caaactgccc tgatgggcag tcaacagcta aaaccttcct      360

caccgtgtac tggactccag aacgggtgga actggcaccc ctcccctctt ggcagccagt      420

gggcaagaac cttaccctac gctgccaggt ggagggtggg gcaccccggg ccaacctcac      480

cgtggtgctg ctccgtgggg agaaggagct gaaacgggag ccagctgtgg gggagcccgc      540

tgaggtcacg accacggtgc tggtgaggag agatcaccat ggagccaatt tctcgtgccg      600

cactgaactg gacctgcggc cccaagggct ggagctgttt gagaacacct cggcccccta      660

ccagctccag acctttgtcc tgccagcgac tcccccacaa cttgtcagcc cccgggtcct      720

agaggtggac acgcagggga ccgtggtctg ttccctggac gggctgttcc cagtctcgga      780

ggcccaggtc cacctggcac tgggggacca gaggttgaac cccacagtca cctatggcaa      840

cgactccttc tcggccaagg cctcagtcag tgtgaccgca gaggacgagg gcacccagcg      900

gctgacgtgt gcagtaatac tggggaacca gagccaggag acactgcaga cagtgaccat      960

ctacagcttt ccggcgccca acgtgattct gacgaagcca gaggtctcag aagggaccga     1020

ggtgacagtg aagtgtgagg cccaccctag agccaaggtg acgctgaatg gggttccagc     1080

ccagccactg ggcccgaggg cccagctcct gctgaaggcc accccagagg acaacgggcg     1140

cagcttctcc tgctctgcaa ccctggaggt ggccggccag cttatacaca agaaccagac     1200

ccgggagctt cgtgtcctgt atggcccccg actggacgag agggattgtc cgggaaactg     1260

gacgtggcca gaaaattccc agcagactcc aatgtgccag gcttggggga acccattgcc     1320

cgagctcaag tgtctaaagg atggcacttt cccactgccc atcggggaat cagtgactgt     1380

cactcgagat cttgagggca cctacctctg tcgggccagg agcactcaag gggaggtcac     1440

ccgcaaggtg accgtgaatg tgctctcccc ccggtatgag attgtcatca tcactgtggt     1500

agcagccgca gtcataatgg gcactgcagg cctcagcacg tacctctata accgccagcg     1560

gaagatcaag aaatacagac tacaacaggc ccaaaaaggg acccccatga aaccgaacac     1620

acaagccacg cctccctgaa cctatcccgg gacagggcct cttcctcggc cttcccatat     1680

tggtggcagt ggtgccacac tgaacagagt ggaagacata tgccatgcag ctacacctac     1740

cggccctggg acgccggagg acagggcatt gtcctcagtc agatacaaca gcatttgggg     1800

ccatggtacc tgcacaccta aaacactagg ccacgcatct gatctgtagt cacatgacta     1860

agccaagagg aaggagcaag actcaagaca tgattgatgg atgttaaagt ctagcctgat     1920

gagaggggaa gtggtggggg agacatagcc ccaccatgag gacatacaac tgggaaatac     1980

tgaaacttgc tgcctattgg gtatgctgag gccccacaga cttacagaag aagtggccct     2040

ccatagacat gtgtagcatc aaaacacaaa ggcccacact tcctgacgga tgccagcttg     2100

ggcactgctg tctactgacc ccaacccttg atgatatgta tttattcatt tgttatttta     2160

ccagctattt attgagtgtc ttttatgtag gctaaatgaa cataggtctc tggcctcacg     2220

gagctcccag tcctaatcac attcaaggtc accaggtaca gttgtacagg ttgtacactg     2280

caggagagtg cctggcaaaa agatcaaatg gggctgggac ttctcattgg ccaacctgcc     2340

tttccccaga aggagtgatt tttctatcgg cacaaaagca ctatatggac tggtaatggt     2400

tacaggttca gagattaccc agtgaggcct tattcctccc ttccccccaa aactgacacc     2460

tttgttagcc acctccccac ccacatacat ttctgccagt gttcacaatg acactcagcg     2520

gtcatgtctg gacatgagtg cccagggaat atgcccaagc tatgccttgt cctcttgtcc     2580

tgtttgcatt tcactgggag cttgcactat gcagctccag tttcctgcag tgatcagggt     2640

cctgcaagca gtggggaagg gggccaaggt attggaggac tccctcccag ctttggaagc     2700

ctcatccgcg tgtgtgtgtg tgtgtatgtg tagacaagct ctcgctctgt cacccaggct     2760

ggagtgcagt ggtgcaatca tggttcactg cagtcttgac cttttgggct caagtgatcc     2820

tcccacctca gcctcctgag tagctgggac cataggctca caacaccaca cctggcaaat     2880

ttgatttttt ttttttttcc agagacgggg tctcgcaaca ttgcccagac ttcctttgtg     2940

ttagttaata aagctttctc aactgcc                                         2967


<210>  55
<211>  1502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  55

Asp Gln Pro Thr Ala Ala Cys Ile Cys Ile Gln Arg Gln Val Pro Pro 
1               5                   10                  15      


Val Pro Ala Ala Arg Ala Pro Gln Ser Arg Thr Arg Ser Ala Gln Ala 
            20                  25                  30          


Lys Leu Ala Leu Thr Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys 
        35                  40                  45              


Tyr Leu Leu Phe Gly Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala 
    50                  55                  60                  


Val Leu Ala Ile Gly Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser 
65                  70                  75                  80  


Ile Phe Glu Gln Glu Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly 
                85                  90                  95      


Val Tyr Ile Leu Ile Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe 
            100                 105                 110         


Leu Gly Cys Cys Gly Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu 
        115                 120                 125             


Phe Phe Gly Phe Leu Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala 
    130                 135                 140                 


Ile Trp Gly Tyr Ser His Lys Asp Glu Val Ile Lys Glu Val Gln Glu 
145                 150                 155                 160 


Phe Tyr Lys Asp Thr Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln 
                165                 170                 175     


Arg Glu Thr Leu Lys Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu 
            180                 185                 190         


Ala Gly Gly Val Glu Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp 
        195                 200                 205             


Val Leu Glu Thr Phe Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu 
    210                 215                 220                 


Val Phe Asp Asn Lys Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile 
225                 230                 235                 240 


Ala Val Val Met Ile Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys 
                245                 250                 255     


Ala Ile Arg Arg Asn Arg Glu Met Val Ser Gln Leu Thr Ser Leu Ser 
            260                 265                 270         


Arg Lys Val Tyr Pro Arg Leu Val Gly Phe Phe Val Cys Leu Phe Cys 
        275                 280                 285             


Phe Val Cys Cys Leu Leu Phe Val Phe Leu Pro Leu Ile Leu Val Phe 
    290                 295                 300                 


Ile Leu His Cys Ile Lys Ala Glu Val Thr Leu Cys Leu Ser Phe Asn 
305                 310                 315                 320 


Ala Ser Phe Asn Ile Asp Ile Cys Ser Ala Gly Gly Leu Val Cys Phe 
                325                 330                 335     


Gly Leu Tyr Phe Phe Ser Cys Leu Phe Leu Leu Val Ile Leu Ser Arg 
            340                 345                 350         


Asn Pro Ala Met Lys Gly Thr Ile Phe Ala Arg Leu Thr Arg Tyr Cys 
        355                 360                 365             


Thr Lys Asn Phe Phe Val Phe Lys Ile Gln Met Ser Ile Asn Phe Asn 
    370                 375                 380                 


Gln Val Val Thr Tyr Ile Glu Asp Asn Leu Ile His Asn Lys Lys Leu 
385                 390                 395                 400 


Gln Cys Gln Lys Lys Lys Lys Arg Leu Gln Gly Arg Arg Arg Gln Gly 
                405                 410                 415     


Phe Ser Pro Met Lys Ile Lys His Ile Leu Leu Leu Gly Val Arg His 
            420                 425                 430         


Cys Met Cys Pro Cys Leu Met Leu Glu Met Met His Met Lys Arg Leu 
        435                 440                 445             


Tyr Met Ser Asn Tyr Pro Trp Val Phe Ile Ser Leu Arg Phe Ser Cys 
    450                 455                 460                 


Cys Phe Ile Phe Pro Ile Arg Lys Arg Ser Lys Thr Val Lys Ser Gln 
465                 470                 475                 480 


Ile Thr Leu Ala Trp Tyr Asn Leu Thr Ala Val Leu Ala Ile Tyr Met 
                485                 490                 495     


Ile Ile Ser Gln Gly Ile Leu Ala Phe Ser Trp Met Ala His Ser Ala 
            500                 505                 510         


Glu Arg Lys Arg Thr Ser Val Ser Gln Cys Met Leu Pro Val Lys Met 
        515                 520                 525             


Lys Arg Lys Trp Thr Ile Ser Thr Ala Glu Leu Gln Tyr Leu Asn Met 
    530                 535                 540                 


Arg Leu Ser Leu Phe Met Gly Leu Thr Gln Leu His Leu Cys Met Asp 
545                 550                 555                 560 


Gln Met Met Lys Met Ser Leu Lys Arg Ala Trp Trp Arg Lys Thr Leu 
                565                 570                 575     


Ser Met Leu Ser Thr Leu Ala Ile Val Trp Leu Pro Met Leu Val Trp 
            580                 585                 590         


Lys Trp Tyr Gln Ile Leu Leu Ala Pro Lys Leu Ile Ser Cys Ser Thr 
        595                 600                 605             


Phe Trp Met Ser Arg Leu Leu Leu Glu Asn Ala Thr Leu Lys Ile Ile 
    610                 615                 620                 


Lys Glu Cys Val His Ser Ser Lys Arg Val Gln Cys Arg Pro Lys Ala 
625                 630                 635                 640 


Ser Ser Ser Cys Pro Arg Leu Ile Arg Gly Tyr Cys Thr Ala Lys Leu 
                645                 650                 655     


Ile His Ile Val Ile Ser Cys Val Ile Leu Gly Lys Trp Lys Val Glu 
            660                 665                 670         


Lys Lys Pro Val Phe Ile Ser Asn Trp Lys Ala Gly His Pro Phe Lys 
        675                 680                 685             


Trp Met Arg Leu Gln His Ser Ser Leu Lys Glu Gln Gln Val Phe Gln 
    690                 695                 700                 


Ser Gln Ile Gln Glu Leu Asn Thr Arg Met Arg Met Leu Arg Met Phe 
705                 710                 715                 720 


Tyr Trp Lys Asp Tyr Ile Ile Lys Asp Pro Asn Val Ile Ser Pro Leu 
                725                 730                 735     


Phe Gln Val Ala Cys Tyr Leu Asp Leu Leu Tyr Phe Cys Ser His Met 
            740                 745                 750         


Leu Cys Gly Arg Leu Ala Ser Leu Lys Asp Asn Thr Asn Leu Ser Tyr 
        755                 760                 765             


Lys Lys Lys Thr Glu Glu Thr Val Gly Val Ile Ser Thr Val Lys Ala 
    770                 775                 780                 


Met Met Ile Lys Asp Phe Phe Gln Ile Glu Arg Met Glu Asn Arg Leu 
785                 790                 795                 800 


Arg Leu Arg Asn Leu Lys Asp Thr Val Tyr Lys Lys Lys Ile Leu Phe 
                805                 810                 815     


Gly Leu Leu Leu Leu Met Ile Leu His Ile Met Ser Ser Cys Lys Gly 
            820                 825                 830         


Lys Ile Ser Ala Met Ile Thr Leu Asp Arg Arg Thr Ala Lys Val Ile 
        835                 840                 845             


Ile Gln Pro Lys Ile Ile Ser Gln Leu Leu Asn Gly Arg Asn Thr Lys 
    850                 855                 860                 


Ala Phe Asn Leu Phe Lys Lys Ser Lys Pro Leu Lys Ile Ser Asn Glu 
865                 870                 875                 880 


Ser Ile Thr Glu Leu Asn Tyr Thr Gly Glu Val Leu Asp Leu Lys Tyr 
                885                 890                 895     


Tyr Leu Pro Tyr Val Leu Ala Ser Val Lys Thr Pro Leu Gly Gly Gln 
            900                 905                 910         


Arg Phe Ile Ser Asn Thr Ser Leu Ile Leu Val Gln Asn Met Phe Phe 
        915                 920                 925             


Lys Asn Ile Ile Phe Arg Ala Val Pro Lys Phe Ser Asn Glu Trp Thr 
    930                 935                 940                 


Ile Ile Thr Leu Lys Pro Phe Ile Tyr Asn Thr Phe Pro Thr Gly Cys 
945                 950                 955                 960 


Val Pro Thr Thr Ile Phe Phe Gln Gln Thr Met Asn Ile Ile Val Leu 
                965                 970                 975     


Ala Lys Leu Ala Asn Phe Arg Leu Asn Met Tyr Thr Gly Leu Ser Leu 
            980                 985                 990         


Val Lys Leu Leu Asp Asn Tyr Phe  Phe Ile Ile Met Asp  Phe Thr Ile 
        995                 1000                 1005             


Phe Leu  Ser Val Tyr Ile His  Val Phe Leu Cys Arg  Tyr Ile Phe 
    1010                 1015                 1020             


Thr Ile  Leu Pro Ile Tyr Ser  Ser Tyr Asn Thr Pro  Leu Ser Ser 
    1025                 1030                 1035             


Ile Pro  Arg Ser Asn Leu Gln  Ile Phe Cys Tyr Ile  Leu Lys Gln 
    1040                 1045                 1050             


Lys Ile  Val Ser Val Ala Leu  Tyr Leu Ile His Ala  Asp Leu Glu 
    1055                 1060                 1065             


Asn Thr  Glu Thr Ile Pro His  Leu Asn Gln Ser Cys  Ala Lys Thr 
    1070                 1075                 1080             


Arg Gly  Pro Ile Leu His Met  Tyr Tyr Val Leu Cys  Lys Ile Leu 
    1085                 1090                 1095             


Thr Ile  Thr Gln Leu Phe Pro  Trp Met Phe Phe Val  Thr Leu Tyr 
    1100                 1105                 1110             


Lys Tyr  Lys Cys Tyr Leu Thr  Trp Lys Arg Arg Asn  Lys Ile His 
    1115                 1120                 1125             


Lys Phe  Lys Phe Ile Asn Leu  Ala Glu Arg Tyr Phe  Asn Leu Tyr 
    1130                 1135                 1140             


Thr Val  Asn Ile Asn Glu Thr  Thr Ala Lys Phe Ser  Asn Val Lys 
    1145                 1150                 1155             


Tyr Phe  Tyr Ser Leu Phe Ile  Leu Tyr Glu Val Leu  Phe Met Thr 
    1160                 1165                 1170             


Phe Trp  Ile Leu Lys Asn Phe  Phe Lys Tyr Asn His  Phe Cys Asn 
    1175                 1180                 1185             


Ile Tyr  Phe Met Leu Met Ile  Ile Ile Ala Glu Tyr  His Phe Ile 
    1190                 1195                 1200             


Leu Cys  Leu His Lys Arg Ala  Val Ala Glu Phe Thr  Ser Val Ile 
    1205                 1210                 1215             


Gly Ser  Asp Gln Ile Arg Arg  Gln Cys Gly Lys Thr  Ile Leu Gly 
    1220                 1225                 1230             


Lys Ile  Ser Leu Tyr Glu Val  Pro Ala Thr Ser Gln  Pro Ser Leu 
    1235                 1240                 1245             


Met Lys  Val Ile Cys Ser Gln  Ala Cys Ser Asp Gly  Glu Glu Cys 
    1250                 1255                 1260             


Ser Glu  Ile Cys Glu Gly Ile  Val Val Lys Cys Lys  His Lys Thr 
    1265                 1270                 1275             


Ser Thr  Gln Ser Val Tyr Thr  Gln Glu Thr Leu His  Leu Cys Ile 
    1280                 1285                 1290             


Phe Lys  Lys Leu Cys Ile Val  Ile Lys Arg Leu Val  Ile Leu Ser 
    1295                 1300                 1305             


Gly Glu  His Leu Gly Ser Met  Lys Asn Gln Ala Pro  Ile Asn Cys 
    1310                 1315                 1320             


Leu Leu  Gln Asp Cys Leu Gly  Asn Leu His Leu Val  Leu Ser Tyr 
    1325                 1330                 1335             


Ser Glu  Leu Leu Arg Asn Asn  Tyr Ile Phe Gln Val  Ile Ala Gln 
    1340                 1345                 1350             


Lys Gln  Ser Thr Met Val Val  Gln His Arg Pro Leu  Arg Tyr Lys 
    1355                 1360                 1365             


Gly Asn  Thr Ile Thr Tyr Trp  Ala Arg Phe Cys Pro  Val Gln Asn 
    1370                 1375                 1380             


Ser Ile  Cys Tyr Gln Leu Thr  Leu Leu Leu Val Ser  Ile Leu Lys 
    1385                 1390                 1395             


Pro Tyr  His Phe Lys Lys Thr  Gly Met Gly Tyr Ser  Phe Leu Ala 
    1400                 1405                 1410             


Gly Arg  Leu Tyr Asn Tyr Val  Ile Leu Lys Phe Asn  Cys Ser Gly 
    1415                 1420                 1425             


Leu Gly  Ser Ser Glu Ser Arg  Gln Thr Tyr Glu Ile  Cys Ile Ile 
    1430                 1435                 1440             


Phe Val  Thr Glu Tyr Arg Lys  Phe Asn Ile Ile Asp  Glu Leu Lys 
    1445                 1450                 1455             


Ser Lys  Met Lys Glu Ser Lys  Leu Phe Gln Asn Tyr  Leu Gly Ile 
    1460                 1465                 1470             


Leu Met  Tyr Tyr Asp Gly Cys  Lys Val Phe Cys Val  Ser Asn Lys 
    1475                 1480                 1485             


His Ile  Val Lys Lys Arg Ile  Ile Asp Ile Lys Lys  Lys Lys 
    1490                 1495                 1500         


<210>  56
<211>  3459
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  56
gtttttgaag ccccatgaaa ataaaacata tcttgctgtt gggagtatga agacattgat       60

gttgaatgtg tccttgttta atgctggaga tgatgcatat gaaacgactc tacatgtcaa      120

actacccgtg ggtctttatt tcattaagat tttagagctg ttgtttcatt tttcccatta      180

ggaagagaag caaataaact gtgaagtcac agataactct ggcgtggtac aacttgactg      240

cagtattggc tatatatatg tagatcatct ctcaaggata gatattagct ttctcctgga      300

tgtgagctca ctcagcagag cggaagagga cctcagtatc acagtgcatg ctacctgtga      360

aaatgaagag gaaatggaca atctaaagca cagcagagtg actgtagcaa tacctttaaa      420

atatgaggtt aagctgactg ttcatgggtt tgtaaaccca acttcatttg tgtatggatc      480

aaatgatgaa aatgagcctg aaacgtgcat ggtggagaaa atgaacttaa ctttccatgt      540

tatcaacact ggcaatagta tggctcccaa tgttagtgtg gaaataatgg taccaaattc      600

ttttagcccc caaactgata agctgttcaa cattttggat gtccagacta ctactggaga      660

atgccacttt gaaaattatc aaagagtgtg tgcattagag cagcaaaaga gtgcaatgca      720

gaccttgaaa ggcatagtcc agttcttgtc caagactgat aagaggctat tgtactgcat      780

aaaagctgat ccacattgtt taaatttctt gtgtaatttt gggaaaatgg aaagtggaaa      840

agaagccagt gttcatatcc aactggaagg ccggccatcc attttagaaa tggatgagac      900

ttcagcactc aagtttgaaa taagagcaac aggttttcca gagccaaatc caagagtaat      960

tgaactaaac aaggatgaga atgttgcgca tgttctactg gaaggactac atcatcaaag     1020

acccaaacgt tatttcacca tagtgattat ttcaagtagc ttgctacttg gacttattgt     1080

acttctgttg atctcatatg ttatgtggaa ggctggcttc tttaaaagac aatacaaatc     1140

tatcctacaa gaagaaaaca gaagagacag ttggagttat atcaacagta aaagcaatga     1200

tgattaagga cttctttcaa attgagagaa tggaaaacag actcaggttg tagtaaagaa     1260

atttaaaaga cactgtttac aagaaaaaat gaattttgtt tggacttctt ttactcatga     1320

tcttgtgaca tattatgtct tcatgcaagg ggaaaatctc agcaatgatt actctttgag     1380

atagaagaac tgcaaaggta ataatacagc caaagataat ctctcagctt ttaaatgggt     1440

agagaaacac taaagcattc aatttattca agaaaagtaa gcccttgaag atatcttgaa     1500

atgaaagtat aactgagtta aattatactg gagaagtctt agacttgaaa tactacttac     1560

catatgtgct tgcctcagta aaatgaaccc cactgggtgg gcagaggttc atttcaaata     1620

catctttgat acttgttcaa aatatgttct ttaaaaatat aattttttag agagctgttc     1680

ccaaattttc taacgagtgg accattatca ctttaaagcc ctttatttat aatacatttc     1740

ctacgggctg tgttccaaca accatttttt ttcagcagac tatgaatatt atagtattat     1800

aggccaaact ggcaaacttc agactgaaca tgtacactgg tttgagctta gtgaaatgac     1860

ttctggataa ttattttttt ataattatgg atttcaccat ctttctttct gtatatatac     1920

atgtgttttt atgtaggtat atatttacca ttcttcctat ctattcttcc tataacacac     1980

ctttatcaag catacccagg agtaatcttc aaatcttttg ttatattctg aaacaaaaga     2040

ttgtgagtgt tgcactttac ctgatacatg ctgatttaga aaatacagaa accatacctc     2100

actaataact ttaaaatcaa agctgtgcaa agactagggg gcctatactt catatgtatt     2160

atgtactatg taaaatattg actatcacac aactatttcc ttggatgtaa ttctttgtta     2220

ccctttacaa gtataagtgt taccttacat ggaaacgaag aaacaaaatt cataaattta     2280

aattcataaa tttagctgaa agatactgat tcaatttgta tacagtgaat ataaatgaga     2340

cgacagcaaa attttcatga aatgtaaaat atttttatag tttgttcata ctatatgagg     2400

ttctatttta aatgactttc tggattttaa aaaatttctt taaatacaat catttttgta     2460

atatttattt tatgcttatg atctagataa ttgcagaata tcattttatc tgactctgtc     2520

ttcataagag agctgtggcc gaattttgaa catctgttat agggagtgat caaattagaa     2580

ggcaatgtgg aaaaacaatt ctgggaaaga tttctttata tgaagtccct gccactagcc     2640

agccatccta attgatgaaa gttatctgtt cacaggcctg cagtgatggt gaggaatgtt     2700

ctgagatttg cgaaggcatt tgagtagtga aatgtaagca caaaacctcc tgaacccaga     2760

gtgtgtatac acaggaataa actttatgac atttatgtat ttttaaaaaa ctttgtatcg     2820

ttataaaaag gctagtcatt ctttcaggag aacatctagg atcatagatg aaaaatcaag     2880

ccccgattta gaactgtctt ctccaggatt gtctctaagg aaatttacat ttggttcttt     2940

cctactcaga actactcaga aacaactata tatttcaggt tatttgagca cagtgaaagc     3000

agagtactat ggttgtccaa cacaggcctc tcagatacaa ggggaacaca attacatatt     3060

gggctagatt ttgcccagtt caaaatagta tttgttatca acttactttg ttacttgtat     3120

catgaatttt aaaaccctac cactttaaga agacagggat gggttattct tttttggcag     3180

gtaggctata taactatgtg attttgaaat ttaactgctc tggattaggg agcagtgaat     3240

caaggcagac ttatgaaatc tgtattatat ttgtaacaga atataggaaa tttaacataa     3300

ttgatgagct caaatcctga aaaatgaaag aatccaaatt atttcagaat tatctaggtt     3360

aaatattgat gtattatgat ggttgcaaag ttttttgtgt gtccaataaa cacattgtaa     3420

aaaaaagaat ttgaattgat atttaaaaaa aaaaaaaaa                            3459


<210>  57
<211>  1026
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  57

Gly Gln Arg Ala Ser Ala Gln Arg Arg Arg Arg Arg Arg Pro His Arg 
1               5                   10                  15      


Ala Ser Cys Gln Ala Ser Gly Ala Gln Arg Pro Thr Arg Pro Arg Ala 
            20                  25                  30          


Pro Ala Pro Pro Arg Pro Phe Leu Arg Ala Pro Ala Pro Arg Pro Ala 
        35                  40                  45              


Arg Pro Pro Cys Arg Pro Pro Ala Arg Pro Arg Ala Gly Pro Pro Ala 
    50                  55                  60                  


Ala Gln Asp Arg Pro Ala Pro Arg Arg Pro Pro Ala Ala Arg Ala Ala 
65                  70                  75                  80  


Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val 
                85                  90                  95      


Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala 
            100                 105                 110         


Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu 
        115                 120                 125             


Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile 
    130                 135                 140                 


Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys 
145                 150                 155                 160 


Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr 
                165                 170                 175     


Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly 
            180                 185                 190         


Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
        195                 200                 205             


Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys 
    210                 215                 220                 


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
225                 230                 235                 240 


Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro 
                245                 250                 255     


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
            260                 265                 270         


Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala 
        275                 280                 285             


Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met 
    290                 295                 300                 


Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr Gly Pro Ala Ala 
305                 310                 315                 320 


Leu Ala Thr Gly Thr Ser Ala Val Pro Pro Lys Pro Gly His Phe Arg 
                325                 330                 335     


Gly Gly His His Arg Leu Cys Ile Arg Phe Arg Tyr Tyr Ser Ala Thr 
            340                 345                 350         


Arg Ser Leu Phe Thr Phe Gly Val Leu Phe Leu Phe Thr Phe Leu Leu 
        355                 360                 365             


Pro Phe Gln Gly Arg His Met Val Ala Cys Met Ser Gly Asp Gly Pro 
    370                 375                 380                 


Gly Ser Trp Gly Leu Glu Gly Arg Gly Pro Ser Ala Leu Gly Ser Gln 
385                 390                 395                 400 


Gly Ala Leu Pro Ala Gln Pro Gly Leu Ser Trp Glu Pro Leu Ala Gln 
                405                 410                 415     


Arg Leu Ser Leu Ala Asn Leu Gly Gly Cys Val His Pro Ala Arg Pro 
            420                 425                 430         


Ser Cys Gly Leu His Ser Ser Pro Cys Ser Leu Leu Pro Arg Phe Glu 
        435                 440                 445             


Ser Arg Val Cys Gly His Ser Leu Pro Ser Cys Thr Cys Pro Phe His 
    450                 455                 460                 


Val Ala Phe Asn Cys Asn His Asn Ile Leu Thr Pro Ser Phe Asn Lys 
465                 470                 475                 480 


Glu Gly Thr Ser Gly Met Leu Glu Gln Lys Leu Ile Ser Glu Glu Asp 
                485                 490                 495     


Leu Thr Arg Ala Pro Ser Leu His Ser Ala Asn Cys Ser Leu Ala His 
            500                 505                 510         


Leu Pro Pro Leu His His Asp His Leu Gln Pro Pro Val His Leu Leu 
        515                 520                 525             


Gln Leu His Glu Gly Leu Leu Arg His Arg Gly Arg His Arg Gly Arg 
    530                 535                 540                 


Leu Gln Pro His Leu Leu Arg Pro Gly Arg Arg Val Leu Pro Arg Pro 
545                 550                 555                 560 


Gln His Leu Arg Gly Arg Pro Val Cys Leu Ile Leu Pro Leu Leu Leu 
                565                 570                 575     


Trp Gly Ser Leu Arg Ala Gly Gly Arg Leu Trp Arg Trp Leu Gln Gln 
            580                 585                 590         


Gln Gln Gln Gln Leu Trp Trp Leu Trp Gly Arg Ile Trp Trp Trp Pro 
        595                 600                 605             


Trp Cys Trp Leu Gly Trp Trp Leu Trp Trp Trp Leu Cys Trp Trp Trp 
    610                 615                 620                 


Ala Ser Gly Gly Gln Glu Gly Asp His Ala Glu Pro Gln Pro Pro Gly 
625                 630                 635                 640 


Leu Leu Pro Gly Gln Gly Ala Cys Ser Gly Gly Gly Gln Arg Arg Pro 
                645                 650                 655     


Gly Ser Glu Asp Pro Leu Val Pro Glu Ala Ala Ala Cys Asp Gln Arg 
            660                 665                 670         


Leu Gln Ser Leu Leu Gln Asp His Gly Pro Glu Glu Gln Asp Ser His 
        675                 680                 685             


Ser His Ser Gly Gln Cys Gln Cys Pro Ser Ala Asp Gln Cys Pro Ser 
    690                 695                 700                 


Gly Arg Gly Leu Pro His Gln Val Asp Arg Val Glu Pro Ala His Glu 
705                 710                 715                 720 


Cys Gly Ser Arg His Gln Trp Pro Ala Gln Gly Ala Gly Arg Thr Asp 
                725                 730                 735     


Pro Gly Gln Ser Pro Gly Asp Ala Asp Glu Pro Glu Gly Gly Ala Gly 
            740                 745                 750         


Leu Pro Glu Glu Glu Pro Arg Gly Gly Asp Glu Cys Pro Glu Arg Pro 
        755                 760                 765             


Gly Gly Trp Arg Cys Gln Cys Gly Asp Gly Arg Cys Thr Trp Arg Gly 
    770                 775                 780                 


Pro Glu Pro His Ser Glu Arg Asp Ala Pro Val Glu Asp Gly Arg Glu 
785                 790                 795                 800 


Glu Pro Gln Gly Cys Arg Gly Met Val Leu His Gln Asp Arg Gly Ala 
                805                 810                 815     


Glu Pro Arg Gly Gly His Gln Gln Arg Ala Gly Ala Glu Arg Gln Glu 
            820                 825                 830         


Arg Asp Leu Gly Ala Pro Ala His His Ala Glu Pro Gly Asp Ala Ala 
        835                 840                 845             


Val Pro Ala Gln His Glu Ser Ile Pro Gly Glu Gln Pro Gly Gly Asp 
    850                 855                 860                 


Gln Arg Ser Leu Leu His Ala Ala Gly Pro Asp Pro Gly Asp Asp Trp 
865                 870                 875                 880 


Gln Arg Gly Gly Ala Ala Gly Pro Ala Pro Leu Arg Asp Gly Ala Ala 
                885                 890                 895     


Glu Pro Gly Val Gln Asp Pro Ala Gly Arg Glu Asp Ala Ala Gly Ala 
            900                 905                 910         


Gly Asp Arg His Leu Pro Pro Pro Ala Gly Gly Arg Gly Arg Pro Pro 
        915                 920                 925             


Leu Leu Leu Pro Val Leu Leu Trp Ile Ala Val Ile Gln Arg Cys Asp 
    930                 935                 940                 


Leu Leu Gln Pro Pro Asn Pro His Gln Gly His Gly Cys Ala Arg Trp 
945                 950                 955                 960 


Gln Gly Gly Val His Pro Arg Ala Gly Pro Ser His Gln Glu Leu Arg 
                965                 970                 975     


Leu Pro Ser Pro Ala Gln Ala Glu Ala Pro Arg Val Asp Thr Asp Pro 
            980                 985                 990         


Thr Gly Arg Ser Pro Leu Leu Pro  Lys His Phe Thr Ala  Gly Pro Cys 
        995                 1000                 1005             


Phe Thr  Leu Thr Pro Ser Trp  Gln Ser Ile Gln Leu  His Tyr Leu 
    1010                 1015                 1020             


Ser Cys  Ile 
    1025     


<210>  58
<211>  3148
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  58
ggccagagag cgagcgcgca acggcggcga cggcggcgac cccaccgcgc atcctgccag       60

gcctccggcg cccagcgccc cacgcgcccc cgcgcccccg cgcccccgcg cccctttctt      120

cgcgcccccg cccctcggcc cgccaggccc ccttgccggc cacccgccag gccccgcgcc      180

ggcccgcccg ccgcccagga ccggcccgcg ccccgcaggc cgcccgccgc ccgcgccgcc      240

atgggagtgg agggctgcac caagtgcatc aagtacctgc tcttcgtctt caatttcgtc      300

ttctggctgg ctggaggcgt gatcctgggt gtggccctgt ggctccgcca tgacccgcag      360

accaccaacc tcctgtatct ggagctggga gacaagcccg cgcccaacac cttctatgta      420

ggcatctaca tcctcatcgc tgtgggcgct gtcatgatgt tcgttggctt cctgggctgc      480

tacggggcca tccaggaatc ccagtgcctg ctggggacgt tcttcacctg cctggtcatc      540

ctgtttgcct gtgaggtggc cgccggcatc tggggctttg tcaacaagga ccagatcgcc      600

aaggatgtga agcagttcta tgaccaggcc ctacagcagg ccgtggtgga tgatgacgcc      660

aacaacgcca aggctgtggt gaagaccttc cacgagacgc ttgactgctg tggctccagc      720

acactgactg ctttgaccac ctcagtgctc aagaacaatt tgtgtccctc gggcagcaac      780

atcatcagca acctcttcaa ggaggactgc caccagaaga tcgatgacct cttctccggg      840

aagctgtacc tcatcggcat tgctgccatc gtggtcgctg tgatcatgat cttcgagatg      900

atcctgagca tggtgctgtg ctgtggcatc cggaacagct ccgtgtactg aggccccgca      960

gctctggcca cagggacctc tgcagtgccc cctaagtgac ccggacactt ccgagggggc     1020

catcaccgcc tgtgtatata acgtttccgg tattactctg ctacacgtag cctttttact     1080

tttggggttt tgtttttgtt ctgaactttc ctgttacctt ttcagggctg acgtcacatg     1140

taggtggcgt gtatgagtgg agacgggcct gggtcttggg gactggaggg caggggtcct     1200

tctgccctgg ggtcccaggg tgctctgcct gctcagccag gcctctcctg ggagccactc     1260

gcccagagac tcagcttggc caacttgggg ggctgtgtcc acccagcccg cccgtcctgt     1320

gggctgcaca gctcaccttg ttccctcctg ccccggttcg agagccgagt ctgtgggcac     1380

tctctgcctt catgcacctg tcctttctaa cacgtcgcct tcaactgtaa tcacaacatc     1440

ctgactccgt catttaataa agaaggaaca tcaggcatgc tagaacaaaa actcatctca     1500

gaagaggatc tgacccgagc accttctctt cactcagcca actgctcgct cgctcacctc     1560

cctcctctgc accatgacca cctgcagccg ccagttcacc tcctccagct ccatgaaggg     1620

ctcctgcggc atcgggggcg gcatcggggg cggctccagc cgcatctcct ccgtcctggc     1680

cggagggtcc tgccgcgccc ccagcaccta cgggggcggc ctgtctgtct catcctcccg     1740

cttctcctct gggggagcct gcgggctggg gggcggctat ggcggtggct tcagcagcag     1800

cagcagcagc tttggtagtg gctttggggg aggatatggt ggtggccttg gtgctggctt     1860

gggtggtggc tttggtggtg gctttgctgg tggtgatggg cttctggtgg gcagtgagaa     1920

ggtgaccatg cagaacctca atgaccgcct ggcctcctac ctggacaagg tgcgtgctct     1980

ggaggaggcc aacgccgacc tggaagtgaa gatccgtgac tggtaccaga ggcagcggcc     2040

tgctgagatc aaagactaca gtccctactt caagaccatt gaggacctga ggaacaagat     2100

tctcacagcc acagtggaca atgccaatgt ccttctgcag attgacaatg cccgtctggc     2160

cgcggatgac ttccgcacca agtatgagac agagttgaac ctgcgcatga gtgtggaagc     2220

cgacatcaat ggcctgcgca gggtgctgga cgaactgacc ctggccagag ctgacctgga     2280

gatgcagatt gagagcctga aggaggagct ggcctacctg aagaagaacc acgaggagga     2340

gatgaatgcc ctgagaggcc aggtgggtgg agatgtcaat gtggagatgg acgctgcacc     2400

tggcgtggac ctgagccgca ttctgaacga gatgcgtgac cagtatgaga agatggcaga     2460

gaagaaccgc aaggatgccg aggaatggtt cttcaccaag acagaggagc tgaaccgcga     2520

ggtggccacc aacagcgagc tggtgcagag cggcaagagc gagatctcgg agctccggcg     2580

caccatgcag aacctggaga ttgagctgca gtcccagctc agcatgaaag catccctgga     2640

gaacagcctg gaggagacca aaggtcgcta ctgcatgcag ctggcccaga tccaggagat     2700

gattggcagc gtggaggagc agctggccca gctccgctgc gagatggagc agcagaacca     2760

ggagtacaag atcctgctgg acgtgaagac gcggctggag caggagatcg ccacctaccg     2820

ccgcctgctg gagggcgagg acgcccacct ctcctcctcc cagttctcct ctggatcgca     2880

gtcatccaga gatgtgacct cctccagccg ccaaatccgc accaaggtca tggatgtgca     2940

cgatggcaag gtggtgtcca cccacgagca ggtccttcgc accaagaact gaggctgccc     3000

agccccgctc aggcctagga ggccccccgt gtggacacag atcccactgg aagatcccct     3060

ctcctgccca agcacttcac agctggaccc tgcttcaccc tcaccccctc ctggcaatca     3120

atacagcttc attatctgag ttgcataa                                        3148


