                               SEQUENCE LISTING

<110> AFFILOGIC
      APELLIS PHARMACEUTICALS, INC.
 
<120> POLYPEPTIDES FOR COMPLEMENT INHIBITION

<130> 2008575-0558

<140> PCT/US2022/021044
<141> 2022-03-18

<150> EP 21305905.8
<151> 2021-06-30

<150> EP 21305904.1
<151> 2021-06-30

<150> EP 21305336.6
<151> 2021-03-18

<160> 91    

<170> PatentIn version 3.5

<210> 1
<211> 66
<212> PRT
<213> Sulfolobus acidocaldarius

<400> 1
Met Val Lys Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Lys Lys Val Trp Arg Val Gly Lys Met Val Ser Phe 
            20                  25                  30          


Thr Tyr Asp Asp Asn Gly Lys Thr Gly Arg Gly Ala Val Ser Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210> 2
<211> 64
<212> PRT
<213> Saccharolobus solfataricus

<400> 2
Met Ala Thr Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Ile Ser Lys Ile Lys Lys Val Trp Arg Val Gly Lys Met Ile Ser Phe 
            20                  25                  30          


Thr Tyr Asp Glu Gly Gly Gly Lys Thr Gly Arg Gly Ala Val Ser Glu 
        35                  40                  45              


Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Lys Lys 
    50                  55                  60                  


<210> 3
<211> 65
<212> PRT
<213> Sulfolobus acidocaldarius

<400> 3
Met Ala Lys Val Arg Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Lys Lys Val Trp Arg Val Gly Lys Met Val Ser Phe 
            20                  25                  30          


Thr Tyr Asp Asp Asn Gly Lys Thr Gly Arg Gly Ala Val Ser Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Met Asp Met Leu Ala Arg Ala Glu Lys Lys 
    50                  55                  60                  


Lys 
65  


<210> 4
<211> 64
<212> PRT
<213> Saccharolobus shibatae

<400> 4
Met Val Thr Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Lys Lys Val Trp Arg Val Gly Lys Met Ile Ser Phe 
            20                  25                  30          


Thr Tyr Asp Glu Gly Gly Gly Lys Thr Gly Arg Gly Ala Val Ser Glu 
        35                  40                  45              


Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Lys Lys 
    50                  55                  60                  


<210> 5
<211> 64
<212> PRT
<213> Sulfolobus shibatae

<400> 5
Met Ala Thr Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Gln Val Asp 
1               5                   10                  15      


Ile Ser Lys Ile Lys Lys Val Trp Arg Val Gly Lys Met Ile Ser Phe 
            20                  25                  30          


Thr Tyr Asp Glu Gly Gly Gly Lys Thr Gly Arg Gly Ala Val Ser Glu 
        35                  40                  45              


Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Lys Lys 
    50                  55                  60                  


<210> 6
<211> 64
<212> PRT
<213> Sulfolobus tokodaii

<400> 6
Met Val Thr Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Ile Ser Lys Ile Lys Lys Val Trp Arg Val Gly Lys Met Ile Ser Phe 
            20                  25                  30          


Thr Tyr Asp Asp Asn Gly Lys Thr Gly Arg Gly Ala Val Ser Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Ser Gly Lys Lys 
    50                  55                  60                  


<210> 7
<211> 64
<212> PRT
<213> Sulfolobus islandicus

<400> 7
Met Val Thr Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Gln Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Lys Lys Val Trp Arg Val Gly Lys Met Ile Ser Phe 
            20                  25                  30          


Thr Tyr Asp Glu Gly Gly Gly Lys Thr Gly Arg Gly Ala Val Ser Glu 
        35                  40                  45              


Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Lys Lys 
    50                  55                  60                  


<210> 8
<211> 64
<212> PRT
<213> Sulfolobus islandicus

<400> 8
Met Thr Thr Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Gln Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Lys Lys Val Trp Arg Val Gly Lys Met Ile Ser Phe 
            20                  25                  30          


Thr Tyr Asp Glu Gly Gly Gly Lys Thr Gly Arg Gly Ala Val Ser Glu 
        35                  40                  45              


Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Lys Lys 
    50                  55                  60                  


<210> 9
<211> 64
<212> PRT
<213> Sulfolobus islandicus

<400> 9
Met Thr Thr Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Gln Val Asp 
1               5                   10                  15      


Ile Ser Lys Ile Lys Lys Val Trp Arg Val Gly Lys Met Ile Ser Phe 
            20                  25                  30          


Thr Tyr Asp Glu Gly Gly Gly Lys Thr Gly Arg Gly Ala Val Ser Glu 
        35                  40                  45              


Lys Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Gln Lys Lys 
    50                  55                  60                  


<210> 10
<211> 62
<212> PRT
<213> Metallosphaera sedula

<400> 10
Met Ala Thr Lys Ile Lys Phe Lys Tyr Lys Gly Gln Asp Leu Glu Val 
1               5                   10                  15      


Asp Ile Ser Lys Val Lys Lys Val Trp Lys Val Gly Lys Met Val Ser 
            20                  25                  30          


Phe Thr Tyr Asp Asp Asn Gly Lys Thr Gly Arg Gly Ala Val Ser Glu 
        35                  40                  45              


Lys Asp Ala Pro Lys Glu Leu Leu Asn Met Ile Gly Lys Lys 
    50                  55                  60          


<210> 11
<211> 62
<212> PRT
<213> Metallosphaera cuprina

<400> 11
Met Ala Thr Lys Ile Lys Phe Lys Tyr Lys Gly Gln Asp Leu Glu Val 
1               5                   10                  15      


Asp Ile Ser Lys Val Lys Lys Val Trp Lys Val Gly Lys Met Val Ser 
            20                  25                  30          


Phe Thr Tyr Asp Asp Asn Gly Lys Thr Gly Arg Gly Ala Val Ser Glu 
        35                  40                  45              


Lys Asp Ala Pro Lys Glu Leu Leu Ser Met Ile Gly Lys Lys 
    50                  55                  60          


<210> 12
<211> 61
<212> PRT
<213> Acidianus hospitalis

<400> 12
Met Thr Thr Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Ile Ser Lys Ile Lys Lys Val Trp Arg Val Gly Lys Met Ile Ser Phe 
            20                  25                  30          


Thr Tyr Asp Asp Asn Gly Lys Thr Gly Arg Gly Ala Val Ser Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Glu Lys Leu Glu Lys Lys 
    50                  55                  60      


<210> 13
<211> 62
<212> PRT
<213> Acidianus hospitalis

<400> 13
Met Ala Thr Lys Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val 
1               5                   10                  15      


Asp Ile Ser Lys Ile Lys Lys Val Trp Arg Val Gly Lys Met Ile Ser 
            20                  25                  30          


Phe Thr Tyr Asp Asp Asn Gly Lys Thr Gly Arg Gly Ala Val Ser Glu 
        35                  40                  45              


Lys Asp Ala Pro Lys Glu Leu Leu Asp Lys Leu Glu Lys Lys 
    50                  55                  60          


<210> 14
<211> 60
<212> PRT
<213> Acidianus hospitalis

<400> 14
Met Ala Thr Lys Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val 
1               5                   10                  15      


Asp Ile Ser Lys Ile Lys Lys Val Trp Arg Val Gly Lys Met Ile Ser 
            20                  25                  30          


Phe Thr Tyr Asp Asp Asn Gly Lys Thr Gly Arg Gly Ala Val Ser Glu 
        35                  40                  45              


Lys Asp Ala Pro Lys Glu Leu Leu Glu Lys Leu Lys 
    50                  55                  60  


<210> 15
<211> 64
<212> PRT
<213> Sulfurisphaera tokodaii

<400> 15
Met Val Thr Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Ile Ser Lys Ile Lys Lys Val Trp Arg Val Gly Lys Met Ile Ser Phe 
            20                  25                  30          


Thr Tyr Asp Asp Asn Gly Lys Thr Gly Arg Gly Ala Val Ser Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Gln Met Leu Glu Lys Ser Gly Lys Lys 
    50                  55                  60                  


<210> 16
<211> 68
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> V, A or T

<220>
<221> MOD_RES
<222> (3)..(3)
<223> T or K

<220>
<221> MOD_RES
<222> (4)..(4)
<223> K or absent

<220>
<221> MOD_RES
<222> (6)..(6)
<223> R or K

<220>
<221> MOD_RES
<222> (15)..(15)
<223> E or Q

<220>
<221> MOD_RES
<222> (18)..(18)
<223> T or I

<220>
<221> MOD_RES
<222> (31)..(31)
<223> V or I

<220>
<221> MOD_RES
<222> (37)..(39)
<223> This region may encompass one of the following sequences: 
      "EGG" or "DN"

<220>
<221> MOD_RES
<222> (57)..(57)
<223> M or L

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Q, D or E

<220>
<221> MOD_RES
<222> (59)..(59)
<223> M or K

<220>
<221> MOD_RES
<222> (61)..(68)
<223> This region may encompass one of the following sequences: 
      "K" or "EKSGKK" or "EKQKK" or "ARAEREKK" or "ARAEREK" or 
      "ARAERE" or "ARAEKKK" or "EKK" or "EKSGKK" or "ACAEREKK" or
      "ACAEKKK"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 16
Met Xaa Xaa Xaa Val Xaa Phe Lys Tyr Lys Gly Glu Glu Lys Xaa Val 
1               5                   10                  15      


Asp Xaa Ser Lys Ile Lys Lys Val Trp Arg Val Gly Lys Met Xaa Ser 
            20                  25                  30          


Phe Thr Tyr Asp Xaa Xaa Xaa Gly Lys Thr Gly Arg Gly Ala Val Ser 
        35                  40                  45              


Glu Lys Asp Ala Pro Lys Glu Leu Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa 
65              


<210> 17
<211> 68
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> V, A or T

<220>
<221> MOD_RES
<222> (3)..(3)
<223> T or K

<220>
<221> MOD_RES
<222> (4)..(4)
<223> K or absent

<220>
<221> MOD_RES
<222> (6)..(6)
<223> R or K

<220>
<221> MOD_RES
<222> (8)..(10)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(15)
<223> E or Q

<220>
<221> MOD_RES
<222> (17)..(17)
<223> D or E

<220>
<221> MOD_RES
<222> (18)..(18)
<223> T or I

<220>
<221> MOD_RES
<222> (22)..(23)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (31)..(31)
<223> V or I

<220>
<221> MOD_RES
<222> (32)..(32)
<223> A, I, L, V, Y, M, F or H

<220>
<221> MOD_RES
<222> (34)..(34)
<223> S, T or A

<220>
<221> MOD_RES
<222> (37)..(39)
<223> This region may encompass one of the following sequences: 
      "EGG" or "DN" or "DQ"

<220>
<221> MOD_RES
<222> (42)..(42)
<223> T or I

<220>
<221> MOD_RES
<222> (46)..(46)
<223> A, I, L, V, Y, M, F or H

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (57)..(57)
<223> M or L

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Q, D or E

<220>
<221> MOD_RES
<222> (59)..(59)
<223> M, K, or L

<220>
<221> MOD_RES
<222> (61)..(68)
<223> This region may encompass one of the following sequences: 
      "K" or "EKSGKK" or "EKQKK" or "ARAEREKK" or "ARAEREK" or 
      "ARAERE" or "ARAEKKK" or "EKK" or "EKSGKK" or "ACAEREKK" or
      "ACAEKKK"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 17
Met Xaa Xaa Xaa Val Xaa Phe Xaa Xaa Xaa Gly Glu Glu Lys Xaa Val 
1               5                   10                  15      


Xaa Xaa Ser Lys Ile Xaa Xaa Val Tyr Arg Xaa Gly Lys Xaa Xaa Xaa 
            20                  25                  30          


Phe Xaa Tyr Asp Xaa Xaa Xaa Gly Lys Xaa Gly Trp Gly Xaa Val Xaa 
        35                  40                  45              


Glu Lys Asp Ala Pro Lys Glu Leu Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa 
65              


<210> 18
<211> 68
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> V, A or T

<220>
<221> MOD_RES
<222> (3)..(3)
<223> T or K

<220>
<221> MOD_RES
<222> (4)..(4)
<223> K or absent

<220>
<221> MOD_RES
<222> (6)..(6)
<223> R or K

<220>
<221> MOD_RES
<222> (8)..(9)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(15)
<223> E or Q

<220>
<221> MOD_RES
<222> (17)..(17)
<223> D or E

<220>
<221> MOD_RES
<222> (18)..(18)
<223> T or I

<220>
<221> MOD_RES
<222> (22)..(23)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (31)..(31)
<223> V or I

<220>
<221> MOD_RES
<222> (34)..(34)
<223> S, T or A

<220>
<221> MOD_RES
<222> (37)..(39)
<223> This region may encompass one of the following sequences: 
      "EGG" or "DN" or "DQ"

<220>
<221> MOD_RES
<222> (42)..(42)
<223> T or I

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (57)..(57)
<223> M or L

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Q, D or E

<220>
<221> MOD_RES
<222> (59)..(59)
<223> M, K, or L

<220>
<221> MOD_RES
<222> (61)..(68)
<223> This region may encompass one of the following sequences: 
      "K" or "EKSGKK" or "EKQKK" or "ARAEREKK" or "ARAEREK" or 
      "ARAERE" or "ARAEKKK" or "EKK" or "EKSGKK" or "ACAEREKK" or
      "ACAEKKK"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 18
Met Xaa Xaa Xaa Val Xaa Phe Xaa Xaa Thr Gly Glu Glu Lys Xaa Val 
1               5                   10                  15      


Xaa Xaa Ser Lys Ile Xaa Xaa Val Tyr Arg Xaa Gly Lys Xaa Xaa Leu 
            20                  25                  30          


Phe Xaa Tyr Asp Xaa Xaa Xaa Gly Lys Xaa Gly Trp Gly Tyr Val Xaa 
        35                  40                  45              


Glu Lys Asp Ala Pro Lys Glu Leu Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa 
65              


<210> 19
<211> 68
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> V, A or T

<220>
<221> MOD_RES
<222> (3)..(3)
<223> T or K

<220>
<221> MOD_RES
<222> (4)..(4)
<223> K or absent

<220>
<221> MOD_RES
<222> (6)..(6)
<223> R or K

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(15)
<223> E or Q

<220>
<221> MOD_RES
<222> (17)..(17)
<223> D or E

<220>
<221> MOD_RES
<222> (18)..(18)
<223> T or I

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (31)..(31)
<223> V or I

<220>
<221> MOD_RES
<222> (37)..(39)
<223> This region may encompass one of the following sequences: 
      "EGG" or "DN" or "DQ"

<220>
<221> MOD_RES
<222> (57)..(57)
<223> M or L

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Q, D or E

<220>
<221> MOD_RES
<222> (59)..(59)
<223> M, K, or L

<220>
<221> MOD_RES
<222> (61)..(68)
<223> This region may encompass one of the following sequences: 
      "K" or "EKSGKK" or "EKQKK" or "ARAEREKK" or "ARAEREK" or 
      "ARAERE" or "ARAEKKK" or "EKK" or "EKSGKK" or "ACAEREKK" or
      "ACAEKKK"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 19
Met Xaa Xaa Xaa Val Xaa Phe Xaa Ala Thr Gly Glu Glu Lys Xaa Val 
1               5                   10                  15      


Xaa Xaa Ser Lys Ile Xaa Xaa Val Tyr Arg Xaa Gly Lys Asp Xaa Leu 
            20                  25                  30          


Phe Ser Tyr Asp Xaa Xaa Xaa Gly Lys Ile Gly Trp Gly Tyr Val Ser 
        35                  40                  45              


Glu Lys Asp Ala Pro Lys Glu Leu Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa 
65              


<210> 20
<211> 68
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> V, A or T

<220>
<221> MOD_RES
<222> (3)..(3)
<223> T or K

<220>
<221> MOD_RES
<222> (4)..(4)
<223> K or absent

<220>
<221> MOD_RES
<222> (6)..(6)
<223> R or K

<220>
<221> MOD_RES
<222> (15)..(15)
<223> E or Q

<220>
<221> MOD_RES
<222> (17)..(17)
<223> D or E

<220>
<221> MOD_RES
<222> (18)..(18)
<223> T or I

<220>
<221> MOD_RES
<222> (31)..(31)
<223> V or I

<220>
<221> MOD_RES
<222> (37)..(39)
<223> This region may encompass one of the following sequences: 
      "EGG" or "DN" or "DQ"

<220>
<221> MOD_RES
<222> (57)..(57)
<223> M or L

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Q, D or E

<220>
<221> MOD_RES
<222> (59)..(59)
<223> M, K, or L

<220>
<221> MOD_RES
<222> (61)..(68)
<223> This region may encompass one of the following sequences: 
      "K" or "EKSGKK" or "EKQKK" or "ARAEREKK" or "ARAEREK" or 
      "ARAERE" or "ARAEKKK" or "EKK" or "EKSGKK" or "ACAEREKK" or
      "ACAEKKK"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 20
Met Xaa Xaa Xaa Val Xaa Phe Asp Ala Thr Gly Glu Glu Lys Xaa Val 
1               5                   10                  15      


Xaa Xaa Ser Lys Ile Ser Ala Val Tyr Arg Thr Gly Lys Asp Xaa Leu 
            20                  25                  30          


Phe Ser Tyr Asp Xaa Xaa Xaa Gly Lys Ile Gly Trp Gly Tyr Val Ser 
        35                  40                  45              


Glu Lys Asp Ala Pro Lys Glu Leu Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa 
65              


<210> 21
<211> 68
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> V, A or T

<220>
<221> MOD_RES
<222> (3)..(3)
<223> T or K

<220>
<221> MOD_RES
<222> (4)..(4)
<223> K or absent

<220>
<221> MOD_RES
<222> (6)..(6)
<223> R or K

<220>
<221> MOD_RES
<222> (15)..(15)
<223> E or Q

<220>
<221> MOD_RES
<222> (17)..(17)
<223> D or E

<220>
<221> MOD_RES
<222> (18)..(18)
<223> T or I

<220>
<221> MOD_RES
<222> (31)..(31)
<223> V or I

<220>
<221> MOD_RES
<222> (37)..(39)
<223> This region may encompass one of the following sequences: 
      "EGG" or "DN" or "DQ"

<220>
<221> MOD_RES
<222> (57)..(57)
<223> M or L

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Q, D or E

<220>
<221> MOD_RES
<222> (59)..(59)
<223> M, K, or L

<220>
<221> MOD_RES
<222> (61)..(68)
<223> This region may encompass one of the following sequences: 
      "K" or "EKSGKK" or "EKQKK" or "ARAEREKK" or "ARAEREK" or 
      "ARAERE" or "ARAEKKK" or "EKK" or "EKSGKK" or "ACAEREKK" or
      "ACAEKKK"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 21
Met Xaa Xaa Xaa Val Xaa Phe Ala Ala Thr Gly Glu Glu Lys Xaa Val 
1               5                   10                  15      


Xaa Xaa Ser Lys Ile Ala Asn Val Tyr Arg Val Gly Lys Asp Xaa Leu 
            20                  25                  30          


Phe Ser Tyr Asp Xaa Xaa Xaa Gly Lys Ile Gly Trp Gly Tyr Val Ser 
        35                  40                  45              


Glu Lys Asp Ala Pro Lys Glu Leu Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa 
65              


<210> 22
<211> 64
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (7)..(9)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (16)..(16)
<223> E or D

<220>
<221> MOD_RES
<222> (21)..(22)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (31)..(31)
<223> A, I, L, V, Y, M, F or H

<220>
<221> MOD_RES
<222> (33)..(33)
<223> S, T or A

<220>
<221> MOD_RES
<222> (37)..(37)
<223> N or Q

<220>
<221> MOD_RES
<222> (40)..(40)
<223> T or I

<220>
<221> MOD_RES
<222> (44)..(44)
<223> A, I, L, V, Y, M, F or H

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (57)..(57)
<223> M or L

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 22
Met Val Lys Val Lys Phe Xaa Xaa Xaa Gly Glu Glu Lys Glu Val Xaa 
1               5                   10                  15      


Thr Ser Lys Ile Xaa Xaa Val Tyr Arg Xaa Gly Lys Xaa Val Xaa Phe 
            20                  25                  30          


Xaa Tyr Asp Asp Xaa Gly Lys Xaa Gly Trp Gly Xaa Val Xaa Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Xaa Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


<210> 23
<211> 64
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (7)..(8)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (16)..(16)
<223> E or D

<220>
<221> MOD_RES
<222> (21)..(22)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (33)..(33)
<223> S, T or A

<220>
<221> MOD_RES
<222> (37)..(37)
<223> N or Q

<220>
<221> MOD_RES
<222> (40)..(40)
<223> T or I

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (57)..(57)
<223> M or L

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 23
Met Val Lys Val Lys Phe Xaa Xaa Thr Gly Glu Glu Lys Glu Val Xaa 
1               5                   10                  15      


Thr Ser Lys Ile Xaa Xaa Val Tyr Arg Xaa Gly Lys Xaa Val Leu Phe 
            20                  25                  30          


Xaa Tyr Asp Asp Xaa Gly Lys Xaa Gly Trp Gly Tyr Val Xaa Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Xaa Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


<210> 24
<211> 64
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (16)..(16)
<223> E or D

<220>
<221> MOD_RES
<222> (21)..(22)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (37)..(37)
<223> N or Q

<220>
<221> MOD_RES
<222> (57)..(57)
<223> M or L

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 24
Met Val Lys Val Lys Phe Xaa Ala Thr Gly Glu Glu Lys Glu Val Xaa 
1               5                   10                  15      


Thr Ser Lys Ile Xaa Xaa Val Tyr Arg Xaa Gly Lys Asp Val Leu Phe 
            20                  25                  30          


Ser Tyr Asp Asp Xaa Gly Lys Ile Gly Trp Gly Tyr Val Ser Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Xaa Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


<210> 25
<211> 64
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (7)..(9)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (16)..(16)
<223> E or D

<220>
<221> MOD_RES
<222> (21)..(22)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (31)..(31)
<223> A, I, L, V, Y, M, F or H

<220>
<221> MOD_RES
<222> (33)..(33)
<223> S, T or A

<220>
<221> MOD_RES
<222> (41)..(41)
<223> T or I

<220>
<221> MOD_RES
<222> (45)..(45)
<223> A, I, L, V, Y, M, F or H

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (58)..(58)
<223> M or L

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 25
Met Ala Thr Val Lys Phe Xaa Xaa Xaa Gly Glu Glu Lys Glu Val Xaa 
1               5                   10                  15      


Ile Ser Lys Ile Xaa Xaa Val Tyr Arg Xaa Gly Lys Xaa Ile Xaa Phe 
            20                  25                  30          


Xaa Tyr Asp Glu Gly Gly Gly Lys Xaa Gly Trp Gly Xaa Val Xaa Glu 
        35                  40                  45              


Lys Asp Ala Pro Lys Glu Leu Leu Gln Xaa Leu Glu Lys Gln Lys Lys 
    50                  55                  60                  


<210> 26
<211> 63
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (16)..(16)
<223> E or D

<220>
<221> MOD_RES
<222> (21)..(21)
<223> A, S, T, V, I, L, Y, or F

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (26)..(26)
<223> S, T, V, I, L, Y, or F

<220>
<221> MOD_RES
<222> (58)..(58)
<223> M or L

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 26
Met Ala Thr Val Lys Phe Xaa Ala Thr Gly Glu Glu Lys Glu Val Xaa 
1               5                   10                  15      


Ile Ser Lys Ile Xaa Xaa Val Tyr Arg Xaa Gly Lys Asp Ile Leu Phe 
            20                  25                  30          


Ser Tyr Asp Glu Gly Gly Gly Lys Ile Gly Trp Gly Tyr Val Ser Glu 
        35                  40                  45              


Lys Asp Ala Pro Lys Glu Leu Leu Gln Xaa Glu Lys Gln Lys Lys 
    50                  55                  60              


<210> 27
<211> 65
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Met Val Lys Val Lys Phe Glu Ala Thr Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Tyr Gln Val Tyr Arg Ser Gly Lys Glu Val Leu Phe 
            20                  25                  30          


Thr Tyr Asp Asp Asn Gly Lys Thr Gly Trp Gly Tyr Val Ser Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys 
65  


<210> 28

<400> 28
000


<210> 29

<400> 29
000


<210> 30

<400> 30
000


<210> 31

<400> 31
000


<210> 32

<400> 32
000


<210> 33
<211> 65
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Met Val Lys Val Lys Phe Ala Ala Thr Gly Glu Glu Lys Glu Val Glu 
1               5                   10                  15      


Thr Ser Lys Ile Ala Asn Val Tyr Arg Val Gly Lys Asp Val Leu Phe 
            20                  25                  30          


Ser Tyr Asp Asp Gln Gly Lys Ile Gly Trp Gly Tyr Val Ser Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Leu Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys 
65  


<210> 34
<211> 65
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Met Val Lys Val Lys Phe Asp Ala Thr Gly Glu Glu Lys Glu Val Glu 
1               5                   10                  15      


Thr Ser Lys Ile Ser Ala Val Tyr Arg Thr Gly Lys Asp Val Leu Phe 
            20                  25                  30          


Ser Tyr Asp Asp Gln Gly Lys Ile Gly Trp Gly Tyr Val Ser Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Leu Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys 
65  


<210> 35
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 36
<211> 231
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 36
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Asp Phe Thr His Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Pro Tyr Tyr Tyr Gly Thr Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Leu 
225                 230     


<210> 37
<211> 293
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 37
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Ser Gly Gly Ser Gly Ser Ala Gly Ser 
    210                 215                 220                 


Gly Ser Gly Gly Ser Val Lys Val Lys Phe Asp Ala Thr Gly Glu Glu 
225                 230                 235                 240 


Lys Glu Val Glu Thr Ser Lys Ile Ser Ala Val Tyr Arg Thr Gly Lys 
                245                 250                 255     


Asp Val Leu Phe Ser Tyr Asp Asp Gln Gly Lys Ile Gly Trp Gly Tyr 
            260                 265                 270         


Val Ser Glu Lys Asp Ala Pro Lys Glu Leu Leu Asp Leu Leu Ala Arg 
        275                 280                 285             


Ala Glu Arg Glu Lys 
    290             


<210> 38
<211> 309
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Asp Phe Thr His Tyr 
            20                  25                  30          


Gly Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
        35                  40                  45              


Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe Lys 
    50                  55                  60                  


Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Tyr Pro Tyr Tyr Tyr Gly Thr Ser His Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Leu Gly Ser Gly Gly Ser Gly Ser Ala Gly Ser 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Val Lys Val Lys Phe Asp Ala Thr Gly Glu Glu 
                245                 250                 255     


Lys Glu Val Glu Thr Ser Lys Ile Ser Ala Val Tyr Arg Thr Gly Lys 
            260                 265                 270         


Asp Val Leu Phe Ser Tyr Asp Asp Gln Gly Lys Ile Gly Trp Gly Tyr 
        275                 280                 285             


Val Ser Glu Lys Asp Ala Pro Lys Glu Leu Leu Asp Leu Leu Ala Arg 
    290                 295                 300                 


Ala Glu Arg Glu Lys 
305                 


<210> 39
<211> 293
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 39
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Ser Gly Gly Ser Gly Ser Ala Gly Ser 
    210                 215                 220                 


Gly Ser Gly Gly Ser Val Lys Val Lys Phe Glu Ala Thr Gly Glu Glu 
225                 230                 235                 240 


Lys Glu Val Asp Thr Ser Lys Ile Tyr Gln Val Tyr Arg Ser Gly Lys 
                245                 250                 255     


Glu Val Leu Phe Thr Tyr Asp Asp Asn Gly Lys Thr Gly Trp Gly Tyr 
            260                 265                 270         


Val Ser Glu Lys Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg 
        275                 280                 285             


Ala Glu Arg Glu Lys 
    290             


<210> 40
<211> 310
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 40
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Asp Phe Thr His Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Pro Tyr Tyr Tyr Gly Thr Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Leu Gly Ser Gly Gly Ser Gly Ser Ala Gly 
225                 230                 235                 240 


Ser Gly Ser Gly Gly Ser Val Lys Val Lys Phe Glu Ala Thr Gly Glu 
                245                 250                 255     


Glu Lys Glu Val Asp Thr Ser Lys Ile Tyr Gln Val Tyr Arg Ser Gly 
            260                 265                 270         


Lys Glu Val Leu Phe Thr Tyr Asp Asp Asn Gly Lys Thr Gly Trp Gly 
        275                 280                 285             


Tyr Val Ser Glu Lys Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala 
    290                 295                 300                 


Arg Ala Glu Arg Glu Lys 
305                 310 


<210> 41
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 41
Gly Ser Gly Gly Ser Gly Ser Ala Gly Ser Gly Ser Gly Gly Ser 
1               5                   10                  15  


<210> 42
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 42
Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 
1               5                   10          


<210> 43
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 43
Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr 
1               5                   10                  


<210> 44
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 44
Glu Pro Lys Ser Cys Asp Lys Thr His 
1               5                   


<210> 45

<400> 45
000


<210> 46
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 46
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
1               5                   10  


<210> 47
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 47
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
1               5                   10                  15      


Thr 
    


<210> 48

<400> 48
000


<210> 49

<400> 49
000


<210> 50

<400> 50
000


<210> 51
<211> 62
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 51
Met Ala Thr Val Lys Phe Asp Ala Thr Gly Glu Glu Lys Glu Val Glu 
1               5                   10                  15      


Ile Ser Lys Ile Ser Ala Val Tyr Arg Thr Gly Lys Asp Ile Leu Phe 
            20                  25                  30          


Ser Tyr Asp Glu Gly Gly Gly Lys Ile Gly Trp Gly Tyr Val Ser Glu 
        35                  40                  45              


Lys Asp Ala Pro Lys Glu Leu Leu Gln Leu Leu Glu Lys Gln 
    50                  55                  60          


<210> 52
<211> 62
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 52
Met Ala Thr Val Lys Phe Ala Ala Thr Gly Glu Glu Lys Glu Val Glu 
1               5                   10                  15      


Ile Ser Lys Ile Ala Asn Val Tyr Arg Val Gly Lys Asp Ile Leu Phe 
            20                  25                  30          


Ser Tyr Asp Glu Gly Gly Gly Lys Ile Gly Trp Gly Tyr Val Ser Glu 
        35                  40                  45              


Lys Asp Ala Pro Lys Glu Leu Leu Gln Leu Leu Glu Lys Gln 
    50                  55                  60          


<210> 53
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 53
Ile Cys Val Val Gln Asp Trp Gly His His Arg Cys Thr 
1               5                   10              


<210> 54

<400> 54
000


<210> 55
<211> 293
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 55
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Ser Gly Gly Ser Gly Ser Ala Gly Ser 
    210                 215                 220                 


Gly Ser Gly Gly Ser Val Lys Val Lys Phe Ala Ala Thr Gly Glu Glu 
225                 230                 235                 240 


Lys Glu Val Glu Thr Ser Lys Ile Ala Asn Val Tyr Arg Val Gly Lys 
                245                 250                 255     


Asp Val Leu Phe Ser Tyr Asp Asp Gln Gly Lys Ile Gly Trp Gly Tyr 
            260                 265                 270         


Val Ser Glu Lys Asp Ala Pro Lys Glu Leu Leu Asp Leu Leu Ala Arg 
        275                 280                 285             


Ala Glu Arg Glu Lys 
    290             


<210> 56
<211> 310
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 56
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Asp Phe Thr His Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Pro Tyr Tyr Tyr Gly Thr Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Leu Gly Ser Gly Gly Ser Gly Ser Ala Gly 
225                 230                 235                 240 


Ser Gly Ser Gly Gly Ser Val Lys Val Lys Phe Ala Ala Thr Gly Glu 
                245                 250                 255     


Glu Lys Glu Val Glu Thr Ser Lys Ile Ala Asn Val Tyr Arg Val Gly 
            260                 265                 270         


Lys Asp Val Leu Phe Ser Tyr Asp Asp Gln Gly Lys Ile Gly Trp Gly 
        275                 280                 285             


Tyr Val Ser Glu Lys Asp Ala Pro Lys Glu Leu Leu Asp Leu Leu Ala 
    290                 295                 300                 


Arg Ala Glu Arg Glu Lys 
305                 310 


<210> 57
<211> 292
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 57
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Ser Gly Gly Ser Gly Ser Ala Gly Ser 
    210                 215                 220                 


Gly Ser Gly Gly Ser Val Lys Val Lys Phe Asp Ala Thr Gly Glu Glu 
225                 230                 235                 240 


Lys Glu Val Glu Thr Ser Lys Ile Ser Ala Val Tyr Arg Thr Gly Lys 
                245                 250                 255     


Asp Val Leu Phe Ser Tyr Asp Asp Gln Gly Lys Ile Gly Trp Gly Tyr 
            260                 265                 270         


Val Ser Glu Lys Asp Ala Pro Lys Glu Leu Leu Asp Leu Leu Ala Arg 
        275                 280                 285             


Ala Glu Arg Glu 
    290         


<210> 58
<211> 309
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 58
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Asp Phe Thr His Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Pro Tyr Tyr Tyr Gly Thr Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Leu Gly Ser Gly Gly Ser Gly Ser Ala Gly 
225                 230                 235                 240 


Ser Gly Ser Gly Gly Ser Val Lys Val Lys Phe Asp Ala Thr Gly Glu 
                245                 250                 255     


Glu Lys Glu Val Glu Thr Ser Lys Ile Ser Ala Val Tyr Arg Thr Gly 
            260                 265                 270         


Lys Asp Val Leu Phe Ser Tyr Asp Asp Gln Gly Lys Ile Gly Trp Gly 
        275                 280                 285             


Tyr Val Ser Glu Lys Asp Ala Pro Lys Glu Leu Leu Asp Leu Leu Ala 
    290                 295                 300                 


Arg Ala Glu Arg Glu 
305                 


<210> 59
<211> 309
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 59
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Asp Phe Thr His Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Pro Tyr Tyr Tyr Gly Thr Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Leu Gly Ser Gly Gly Ser Gly Ser Ala Gly 
225                 230                 235                 240 


Ser Gly Ser Gly Gly Ser Val Lys Val Lys Phe Val Phe Ser Gly Glu 
                245                 250                 255     


Glu Lys Glu Val Glu Thr Ser Lys Ile Lys Trp Val Leu Arg Trp Gly 
            260                 265                 270         


Lys Ala Val Gly Phe Lys Tyr Asp Asp Gln Gly Lys Ile Gly Tyr Gly 
        275                 280                 285             


Phe Val Ala Glu Lys Asp Ala Pro Lys Glu Leu Leu Asp Leu Leu Ala 
    290                 295                 300                 


Arg Ala Glu Arg Glu 
305                 


<210> 60
<211> 371
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 60
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Ser Gly Gly Ser Gly Ser Ala Gly Ser 
    210                 215                 220                 


Gly Ser Gly Gly Ser Val Lys Val Lys Phe Asp Ala Thr Gly Glu Glu 
225                 230                 235                 240 


Lys Glu Val Glu Thr Ser Lys Ile Ser Ala Val Tyr Arg Thr Gly Lys 
                245                 250                 255     


Asp Val Leu Phe Ser Tyr Asp Asp Gln Gly Lys Ile Gly Trp Gly Tyr 
            260                 265                 270         


Val Ser Glu Lys Asp Ala Pro Lys Glu Leu Leu Asp Leu Leu Ala Arg 
        275                 280                 285             


Ala Glu Arg Glu Lys Gly Ser Gly Gly Ser Gly Ser Ala Gly Ser Gly 
    290                 295                 300                 


Ser Gly Gly Ser Val Lys Val Lys Phe Val Phe Ser Gly Glu Glu Lys 
305                 310                 315                 320 


Glu Val Glu Thr Ser Lys Ile Lys Trp Val Leu Arg Trp Gly Lys Ala 
                325                 330                 335     


Val Gly Phe Lys Tyr Asp Asp Gln Gly Lys Ile Gly Tyr Gly Phe Val 
            340                 345                 350         


Ala Glu Lys Asp Ala Pro Lys Glu Leu Leu Asp Leu Leu Ala Arg Ala 
        355                 360                 365             


Glu Arg Glu 
    370     


<210> 61
<211> 388
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 61
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Asp Phe Thr His Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Pro Tyr Tyr Tyr Gly Thr Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Leu Gly Ser Gly Gly Ser Gly Ser Ala Gly 
225                 230                 235                 240 


Ser Gly Ser Gly Gly Ser Val Lys Val Lys Phe Asp Ala Thr Gly Glu 
                245                 250                 255     


Glu Lys Glu Val Glu Thr Ser Lys Ile Ser Ala Val Tyr Arg Thr Gly 
            260                 265                 270         


Lys Asp Val Leu Phe Ser Tyr Asp Asp Gln Gly Lys Ile Gly Trp Gly 
        275                 280                 285             


Tyr Val Ser Glu Lys Asp Ala Pro Lys Glu Leu Leu Asp Leu Leu Ala 
    290                 295                 300                 


Arg Ala Glu Arg Glu Lys Gly Ser Gly Gly Ser Gly Ser Ala Gly Ser 
305                 310                 315                 320 


Gly Ser Gly Gly Ser Val Lys Val Lys Phe Val Phe Ser Gly Glu Glu 
                325                 330                 335     


Lys Glu Val Glu Thr Ser Lys Ile Lys Trp Val Leu Arg Trp Gly Lys 
            340                 345                 350         


Ala Val Gly Phe Lys Tyr Asp Asp Gln Gly Lys Ile Gly Tyr Gly Phe 
        355                 360                 365             


Val Ala Glu Lys Asp Ala Pro Lys Glu Leu Leu Asp Leu Leu Ala Arg 
    370                 375                 380                 


Ala Glu Arg Glu 
385             


<210> 62
<211> 371
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 62
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Ser Gly Gly Ser Gly Ser Ala Gly Ser 
    210                 215                 220                 


Gly Ser Gly Gly Ser Val Lys Val Lys Phe Val Phe Ser Gly Glu Glu 
225                 230                 235                 240 


Lys Glu Val Glu Thr Ser Lys Ile Lys Trp Val Leu Arg Trp Gly Lys 
                245                 250                 255     


Ala Val Gly Phe Lys Tyr Asp Asp Gln Gly Lys Ile Gly Tyr Gly Phe 
            260                 265                 270         


Val Ala Glu Lys Asp Ala Pro Lys Glu Leu Leu Asp Leu Leu Ala Arg 
        275                 280                 285             


Ala Glu Arg Glu Lys Gly Ser Gly Gly Ser Gly Ser Ala Gly Ser Gly 
    290                 295                 300                 


Ser Gly Gly Ser Val Lys Val Lys Phe Asp Ala Thr Gly Glu Glu Lys 
305                 310                 315                 320 


Glu Val Glu Thr Ser Lys Ile Ser Ala Val Tyr Arg Thr Gly Lys Asp 
                325                 330                 335     


Val Leu Phe Ser Tyr Asp Asp Gln Gly Lys Ile Gly Trp Gly Tyr Val 
            340                 345                 350         


Ser Glu Lys Asp Ala Pro Lys Glu Leu Leu Asp Leu Leu Ala Arg Ala 
        355                 360                 365             


Glu Arg Glu 
    370     


<210> 63
<211> 388
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 63
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Asp Phe Thr His Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Pro Tyr Tyr Tyr Gly Thr Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Leu Gly Ser Gly Gly Ser Gly Ser Ala Gly 
225                 230                 235                 240 


Ser Gly Ser Gly Gly Ser Val Lys Val Lys Phe Val Phe Ser Gly Glu 
                245                 250                 255     


Glu Lys Glu Val Glu Thr Ser Lys Ile Lys Trp Val Leu Arg Trp Gly 
            260                 265                 270         


Lys Ala Val Gly Phe Lys Tyr Asp Asp Gln Gly Lys Ile Gly Tyr Gly 
        275                 280                 285             


Phe Val Ala Glu Lys Asp Ala Pro Lys Glu Leu Leu Asp Leu Leu Ala 
    290                 295                 300                 


Arg Ala Glu Arg Glu Lys Gly Ser Gly Gly Ser Gly Ser Ala Gly Ser 
305                 310                 315                 320 


Gly Ser Gly Gly Ser Val Lys Val Lys Phe Asp Ala Thr Gly Glu Glu 
                325                 330                 335     


Lys Glu Val Glu Thr Ser Lys Ile Ser Ala Val Tyr Arg Thr Gly Lys 
            340                 345                 350         


Asp Val Leu Phe Ser Tyr Asp Asp Gln Gly Lys Ile Gly Trp Gly Tyr 
        355                 360                 365             


Val Ser Glu Lys Asp Ala Pro Lys Glu Leu Leu Asp Leu Leu Ala Arg 
    370                 375                 380                 


Ala Glu Arg Glu 
385             


<210> 64
<211> 66
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (16)..(16)
<223> D or E

<220>
<221> MOD_RES
<222> (37)..(37)
<223> N or Q 

<220>
<221> MOD_RES
<222> (57)..(57)
<223> M or L

<400> 64
Met Val Lys Val Lys Phe Val Phe Ser Gly Glu Glu Lys Glu Val Xaa 
1               5                   10                  15      


Thr Ser Lys Ile Lys Trp Val Leu Arg Trp Gly Lys Ala Val Gly Phe 
            20                  25                  30          


Lys Tyr Asp Asp Xaa Gly Lys Ile Gly Tyr Gly Phe Val Ala Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Xaa Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210> 65
<211> 66
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (7)..(9)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (21)..(22)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Any amino acid

<400> 65
Met Val Lys Val Lys Phe Xaa Xaa Xaa Gly Glu Glu Lys Glu Val Xaa 
1               5                   10                  15      


Thr Ser Lys Ile Xaa Xaa Val Xaa Arg Xaa Gly Lys Xaa Val Xaa Phe 
            20                  25                  30          


Thr Tyr Asp Asp Xaa Gly Lys Xaa Gly Xaa Gly Xaa Val Xaa Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210> 66
<211> 66
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (7)..(9)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (21)..(22)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (57)..(57)
<223> Any amino acid

<400> 66
Met Val Lys Val Lys Phe Xaa Xaa Xaa Gly Glu Glu Lys Glu Val Xaa 
1               5                   10                  15      


Thr Ser Lys Ile Xaa Xaa Val Xaa Arg Xaa Gly Lys Xaa Val Xaa Phe 
            20                  25                  30          


Xaa Tyr Asp Asp Xaa Gly Lys Xaa Gly Xaa Gly Xaa Val Xaa Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Xaa Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210> 67
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 67
Glu Pro Lys Ser Cys Asp Lys Thr His Leu 
1               5                   10  


<210> 68
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 68
Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu 
1               5                   10                  15      


Asp Asp 
        


<210> 69
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 69
Gln Arg Leu Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Glu Asp Asp Phe 
            20  


<210> 70
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 70
Ser Asp Phe Tyr Lys Arg Leu Ile Asn Lys Ala Lys Thr Val Glu Gly 
1               5                   10                  15      


Val Glu Ala Leu Lys Leu His Ile Leu Ala Ala Leu Pro 
            20                  25                  


<210> 71
<211> 64
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (15)..(15)
<223> D or E

<220>
<221> MOD_RES
<222> (36)..(36)
<223> N or Q 

<220>
<221> MOD_RES
<222> (56)..(56)
<223> M or L

<400> 71
Val Lys Val Lys Phe Val Phe Ser Gly Glu Glu Lys Glu Val Xaa Thr 
1               5                   10                  15      


Ser Lys Ile Lys Trp Val Leu Arg Trp Gly Lys Ala Val Gly Phe Lys 
            20                  25                  30          


Tyr Asp Asp Xaa Gly Lys Ile Gly Tyr Gly Phe Val Ala Glu Lys Asp 
        35                  40                  45              


Ala Pro Lys Glu Leu Leu Asp Xaa Leu Ala Arg Ala Glu Arg Glu Lys 
    50                  55                  60                  


<210> 72
<211> 64
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 72
Val Lys Val Lys Phe Val Phe Ser Gly Glu Glu Lys Glu Val Asp Thr 
1               5                   10                  15      


Ser Lys Ile Lys Trp Val Leu Arg Trp Gly Lys Ala Val Gly Phe Lys 
            20                  25                  30          


Tyr Asp Asp Asn Gly Lys Ile Gly Tyr Gly Phe Val Ala Glu Lys Asp 
        35                  40                  45              


Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu Lys 
    50                  55                  60                  


<210> 73
<211> 64
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 73
Val Lys Val Lys Phe Val Phe Ser Gly Glu Glu Lys Glu Val Glu Thr 
1               5                   10                  15      


Ser Lys Ile Lys Trp Val Leu Arg Trp Gly Lys Ala Val Gly Phe Lys 
            20                  25                  30          


Tyr Asp Asp Gln Gly Lys Ile Gly Tyr Gly Phe Val Ala Glu Lys Asp 
        35                  40                  45              


Ala Pro Lys Glu Leu Leu Asp Leu Leu Ala Arg Ala Glu Arg Glu Lys 
    50                  55                  60                  


<210> 74
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 74
Arg Tyr Pro Ile Ser Arg Pro Arg Lys Arg 
1               5                   10  


<210> 75
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 75
Gly Ala His Trp Gln Phe Asn Ala Leu Thr Val Arg 
1               5                   10          


<210> 76
<211> 68
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> V, A or T

<220>
<221> MOD_RES
<222> (3)..(3)
<223> T or K

<220>
<221> MOD_RES
<222> (4)..(4)
<223> K or absent

<220>
<221> MOD_RES
<222> (6)..(6)
<223> R or K

<220>
<221> MOD_RES
<222> (15)..(15)
<223> E or Q

<220>
<221> MOD_RES
<222> (17)..(17)
<223> D or E

<220>
<221> MOD_RES
<222> (18)..(18)
<223> T or I

<220>
<221> MOD_RES
<222> (31)..(31)
<223> V or I

<220>
<221> MOD_RES
<222> (37)..(39)
<223> This region may encompass one of the following sequences: 
      "EGG" or "DN" or "DQ"

<220>
<221> MOD_RES
<222> (57)..(57)
<223> M or L

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Q, D or E

<220>
<221> MOD_RES
<222> (59)..(59)
<223> M, K, or L

<220>
<221> MOD_RES
<222> (61)..(68)
<223> This region may encompass one of the following sequences: 
      "K" or "EKSGKK" or "EKQKK" or "ARAEREKK" or "ARAEREK" or 
      "ARAERE" or "ARAEKKK" or "EKK" or "EKSGKK" or "ACAEREKK" or
      "ACAEKKK"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 76
Met Xaa Xaa Xaa Val Xaa Phe Lys Tyr Lys Gly Glu Glu Lys Xaa Val 
1               5                   10                  15      


Xaa Xaa Ser Lys Ile Lys Lys Val Trp Arg Val Gly Lys Met Xaa Ser 
            20                  25                  30          


Phe Thr Tyr Asp Xaa Xaa Xaa Gly Lys Thr Gly Arg Gly Ala Val Ser 
        35                  40                  45              


Glu Lys Asp Ala Pro Lys Glu Leu Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa 
65              


<210> 77
<211> 68
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> V, A or T

<220>
<221> MOD_RES
<222> (3)..(3)
<223> T or K

<220>
<221> MOD_RES
<222> (4)..(4)
<223> K or absent

<220>
<221> MOD_RES
<222> (6)..(6)
<223> R or K

<220>
<221> MOD_RES
<222> (8)..(10)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(15)
<223> E or Q

<220>
<221> MOD_RES
<222> (17)..(17)
<223> D or E

<220>
<221> MOD_RES
<222> (18)..(18)
<223> T or I

<220>
<221> MOD_RES
<222> (22)..(23)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (31)..(31)
<223> V or I

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (37)..(39)
<223> This region may encompass one of the following sequences: 
      "EGG" or "DN" or "DQ"

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (46)..(46)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (57)..(57)
<223> M or L

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Q, D or E

<220>
<221> MOD_RES
<222> (59)..(59)
<223> M, K, or L

<220>
<221> MOD_RES
<222> (61)..(68)
<223> This region may encompass one of the following sequences: 
      "K" or "EKSGKK" or "EKQKK" or "ARAEREKK" or "ARAEREK" or 
      "ARAERE" or "ARAEKKK" or "EKK" or "EKSGKK" or "ACAEREKK" or
      "ACAEKKK"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 77
Met Xaa Xaa Xaa Val Xaa Phe Xaa Xaa Xaa Gly Glu Glu Lys Xaa Val 
1               5                   10                  15      


Xaa Xaa Ser Lys Ile Xaa Xaa Val Xaa Arg Xaa Gly Lys Xaa Xaa Xaa 
            20                  25                  30          


Phe Xaa Tyr Asp Xaa Xaa Xaa Gly Lys Xaa Gly Xaa Gly Xaa Val Xaa 
        35                  40                  45              


Glu Lys Asp Ala Pro Lys Glu Leu Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa 
65              


<210> 78
<211> 68
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> V, A or T

<220>
<221> MOD_RES
<222> (3)..(3)
<223> T or K

<220>
<221> MOD_RES
<222> (4)..(4)
<223> K or absent

<220>
<221> MOD_RES
<222> (6)..(6)
<223> R or K

<220>
<221> MOD_RES
<222> (8)..(8)
<223> E, A, or D

<220>
<221> MOD_RES
<222> (15)..(15)
<223> E or Q

<220>
<221> MOD_RES
<222> (17)..(17)
<223> D or E

<220>
<221> MOD_RES
<222> (18)..(18)
<223> T or I

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Y, A, or S

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Q, N, or A

<220>
<221> MOD_RES
<222> (27)..(27)
<223> S, V, or T

<220>
<221> MOD_RES
<222> (30)..(30)
<223> E or D

<220>
<221> MOD_RES
<222> (31)..(31)
<223> V or I

<220>
<221> MOD_RES
<222> (32)..(32)
<223> A, I, L, V, Y, M, F or H

<220>
<221> MOD_RES
<222> (34)..(34)
<223> A, T or S

<220>
<221> MOD_RES
<222> (37)..(39)
<223> This region may encompass one of the following sequences: 
      "EGG" or "DN" or "DQ"

<220>
<221> MOD_RES
<222> (42)..(42)
<223> T or I

<220>
<221> MOD_RES
<222> (46)..(46)
<223> A, I, L, V, Y, M, F or H

<220>
<221> MOD_RES
<222> (57)..(57)
<223> M or L

<220>
<221> MOD_RES
<222> (58)..(58)
<223> Q, D or E

<220>
<221> MOD_RES
<222> (59)..(59)
<223> M, K, or L

<220>
<221> MOD_RES
<222> (61)..(68)
<223> This region may encompass one of the following sequences: 
      "K" or "EKSGKK" or "EKQKK" or "ARAEREKK" or "ARAEREK" or 
      "ARAERE" or "ARAEKKK" or "EKK" or "EKSGKK" or "ACAEREKK" or
      "ACAEKKK"

<400> 78
Met Xaa Xaa Xaa Val Xaa Phe Xaa Ala Thr Gly Glu Glu Lys Xaa Val 
1               5                   10                  15      


Xaa Xaa Ser Lys Ile Xaa Xaa Val Tyr Arg Xaa Gly Lys Xaa Xaa Xaa 
            20                  25                  30          


Phe Xaa Tyr Asp Xaa Xaa Xaa Gly Lys Xaa Gly Trp Gly Xaa Val Ser 
        35                  40                  45              


Glu Lys Asp Ala Pro Lys Glu Leu Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa 
65              


<210> 79
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 79
Ala Arg Ala Glu Arg Glu Lys Lys 
1               5               


<210> 80
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 80
Ala Arg Ala Glu Arg Glu 
1               5       


<210> 81
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 81
Ala Arg Ala Glu Arg Glu Lys 
1               5           


<210> 82
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 82
Glu Lys Ser Gly Lys Lys 
1               5       


<210> 83
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 83
Glu Lys Gln Lys Lys 
1               5   


<210> 84
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 84
Ala Arg Ala Glu Lys Lys Lys 
1               5           


<210> 85
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 85
Ala Cys Ala Glu Arg Glu Lys Lys 
1               5               


<210> 86
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 86
Ala Cys Ala Glu Lys Lys Lys 
1               5           


<210> 87
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> SITE
<222> (1)..(25) 
<223> This sequence may encompass 1-5 "Gly Gly Gly Gly Ser"
      repeating units

<400> 87
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210> 88
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> SITE
<222> (1)..(25) 
<223> This sequence may encompass 1-5 " Ser Gly Gly Gly Gly"
      repeating units

<400> 88
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25  


<210> 89
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> SITE
<222> (1)..(25) 
<223> This sequence may encompass 5-25 residues

<400> 89
Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Gly Gly 
            20                  25  


<210> 90
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid except Proline

<400> 90
Val Pro Gly Xaa Gly 
1               5   


<210> 91
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 91
Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10      

