                         SEQUENCE LISTING

<110>  Mayo Foundation for Medical Education and Research
 
<120>  METHODS AND MATERIALS FOR TREATING PROPIONIC ACIDEMIA

<130>  07039-2019WO1

<150>  US 63/163,198
<151>  2021-03-19

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  2480
<212>  DNA
<213>  Homo sapiens

<400>  1
atggcggggt tctgggtcgg gacagcaccg ctggtcgctg ccggacggcg tgggcggtgg       60

ccgccgcagc agctgatgct gagcgcggcg ctgcggaccc tgaagcatgt tctgtactat      120

tcaagacagt gcttaatggt gtcccgtaat cttggttcag tgggatatga tcctaatgaa      180

aaaacttttg ataaaattct tgttgctaat agaggagaaa ttgcatgtcg ggttattaga      240

acttgcaaga agatgggcat taagacagtt gccatccaca gtgatgttga tgctagttct      300

gttcatgtga aaatggcgga tgaggctgtc tgtgttggcc cagctcccac cagtaaaagc      360

tacctcaaca tggatgccat catggaagcc attaagaaaa ccagggccca agctgtacat      420

ccaggttatg gattcctttc agaaaacaaa gaatttgcca gatgtttggc agcagaagat      480

gtcgttttca ttggacctga cacacatgct attcaagcca tgggcgacaa gattgaaagc      540

aaattattag ctaagaaagc agaggttaat acaatccctg gctttgatgg agtagtcaag      600

gatgcagaag aagctgtcag aattgcaagg gaaattggct accctgtcat gatcaaggcc      660

tcagcaggtg gtggtgggaa aggcatgcgc attgcttggg atgatgaaga gaccagggat      720

ggttttagat tgtcatctca agaagctgct tctagttttg gcgatgatag actactaata      780

gaaaaattta ttgataatcc tcgtcatata gaaatccagg ttctaggtga taaacatggg      840

aatgctttat ggcttaatga aagagagtgc tcaattcaga gaagaaatca gaaggtggtg      900

gaggaagcac caagcatttt tttggatgcg gagactcgaa gagcgatggg agaacaagct      960

gtagctcttg ccagagcagt aaaatattcc tctgctggga ccgtggagtt ccttgtggac     1020

tctaagaaga atttttattt cttggaaatg aatacaagac tccaggttga gcatcctgtc     1080

acagaatgca ttactggcct ggacctagtc caggaaatga tccgtgttgc taagggctac     1140

cctctcaggc acaaacaagc tgatattcgc atcaacggct gggcagttga atgtcgggtt     1200

tatgctgagg acccctacaa gtcttttggt ttaccatcta ttgggagatt gtctcagtac     1260

caagaaccgt tacatctacc tggtgtccga gtggacagtg gcatccaacc aggaagtgat     1320

attagcattt attatgatcc tatgatttca aaactaatca catatggctc tgatagaact     1380

gaggcactga agagaatggc agatgcactg gataactatg ttattcgagg tgttacacat     1440

aatattgcat tacttcgaga ggtgataatc aactcacgct ttgtaaaagg agacatcagc     1500

actaaatttc tctccgatgt gtatcctgat ggcttcaaag gacacatgct aaccaagagt     1560

gagaagaacc agttattggc aatagcatca tcattgtttg tggcattcca gttaagagca     1620

caacattttc aagaaaattc aagaatgcct gttattaaac cagacatagc caactgggag     1680

ctctcagtaa aattgcatga taaagttcat accgtagtag catcaaacaa tgggtcagtg     1740

ttctcggtgg aagttgatgg gtcgaaacta aatgtgacca gcacgtggaa cctggcttcg     1800

cccttattgt ctgtcagcgt tgatggcact cagaggactg tccagtgtct ttctcgagaa     1860

gcaggtggaa acatgagcat tcagtttctt ggtacagtgt acaaggtgaa tatcttaacc     1920

agacttgccg cagaattgaa caaatttatg ctggaaaaag tgactgagga cacaagcagt     1980

gttctgcgtt ccccgatgcc cggagtggtg gtggccgtct ctgtcaagcc tggagacgcg     2040

gtagcagaag gtcaagaaat ttgtgtgatt gaagccatga aaatgcagaa tagtatgaca     2100

gctgggaaaa ctggcacggt gaaatctgtg cactgtcaag ctggagacac agttggagaa     2160

ggggatctgc tcgtggagct ggaatgaagg atttataacc tttcagtcat cacccaattt     2220

aattagccat ttgcatgatg ctttcacaca caattgattc aagcattata caggaacacc     2280

cctgtgcagc tacgtttacg tcgtcattta ttccacagag tcaagaccaa tattctgcca     2340

aaaaatcacc aatggaaatt ttcattgata taaatacttg tacatatgat ttgtacttct     2400

gctgtgagat tccctagtgt caaaattaaa tcaataaaac tgagcatttg tctaaaaaaa     2460

aaaaaaaaaa aaaaaaaaaa                                                 2480


<210>  2
<211>  2405
<212>  DNA
<213>  Homo sapiens

<400>  2
atgctgagcg cggcgctgcg gaccctgaag catgttctgt actattcaag acagtgctta       60

atggtgtccc gtaatcttgg ttcagtggga tatgatccta atgaaaaaac ttttgataaa      120

attcttgttg ctaatagagg agaaattgca tgtcgggtta ttagaacttg caagaagatg      180

ggcattaaga cagttgccat ccacagtgat gttgatgcta gttctgttca tgtgaaaatg      240

gcggatgagg ctgtctgtgt tggcccagct cccaccagta aaagctacct caacatggat      300

gccatcatgg aagccattaa gaaaaccagg gcccaagctg tacatccagg ttatggattc      360

ctttcagaaa acaaagaatt tgccagatgt ttggcagcag aagatgtcgt tttcattgga      420

cctgacacac atgctattca agccatgggc gacaagattg aaagcaaatt attagctaag      480

aaagcagagg ttaatacaat ccctggcttt gatggagtag tcaaggatgc agaagaagct      540

gtcagaattg caagggaaat tggctaccct gtcatgatca aggcctcagc aggtggtggt      600

gggaaaggca tgcgcattgc ttgggatgat gaagagacca gggatggttt tagattgtca      660

tctcaagaag ctgcttctag ttttggcgat gatagactac taatagaaaa atttattgat      720

aatcctcgtc atatagaaat ccaggttcta ggtgataaac atgggaatgc tttatggctt      780

aatgaaagag agtgctcaat tcagagaaga aatcagaagg tggtggagga agcaccaagc      840

atttttttgg atgcggagac tcgaagagcg atgggagaac aagctgtagc tcttgccaga      900

gcagtaaaat attcctctgc tgggaccgtg gagttccttg tggactctaa gaagaatttt      960

tatttcttgg aaatgaatac aagactccag gttgagcatc ctgtcacaga atgcattact     1020

ggcctggacc tagtccagga aatgatccgt gttgctaagg gctaccctct caggcacaaa     1080

caagctgata ttcgcatcaa cggctgggca gttgaatgtc gggtttatgc tgaggacccc     1140

tacaagtctt ttggtttacc atctattggg agattgtctc agtaccaaga accgttacat     1200

ctacctggtg tccgagtgga cagtggcatc caaccaggaa gtgatattag catttattat     1260

gatcctatga tttcaaaact aatcacatat ggctctgata gaactgaggc actgaagaga     1320

atggcagatg cactggataa ctatgttatt cgaggtgtta cacataatat tgcattactt     1380

cgagaggtga taatcaactc acgctttgta aaaggagaca tcagcactaa atttctctcc     1440

gatgtgtatc ctgatggctt caaaggacac atgctaacca agagtgagaa gaaccagtta     1500

ttggcaatag catcatcatt gtttgtggca ttccagttaa gagcacaaca ttttcaagaa     1560

aattcaagaa tgcctgttat taaaccagac atagccaact gggagctctc agtaaaattg     1620

catgataaag ttcataccgt agtagcatca aacaatgggt cagtgttctc ggtggaagtt     1680

gatgggtcga aactaaatgt gaccagcacg tggaacctgg cttcgccctt attgtctgtc     1740

agcgttgatg gcactcagag gactgtccag tgtctttctc gagaagcagg tggaaacatg     1800

agcattcagt ttcttggtac agtgtacaag gtgaatatct taaccagact tgccgcagaa     1860

ttgaacaaat ttatgctgga aaaagtgact gaggacacaa gcagtgttct gcgttccccg     1920

atgcccggag tggtggtggc cgtctctgtc aagcctggag acgcggtagc agaaggtcaa     1980

gaaatttgtg tgattgaagc catgaaaatg cagaatagta tgacagctgg gaaaactggc     2040

acggtgaaat ctgtgcactg tcaagctgga gacacagttg gagaagggga tctgctcgtg     2100

gagctggaat gaaggattta taacctttca gtcatcaccc aatttaatta gccatttgca     2160

tgatgctttc acacacaatt gattcaagca ttatacagga acacccctgt gcagctacgt     2220

ttacgtcgtc atttattcca cagagtcaag accaatattc tgccaaaaaa tcaccaatgg     2280

aaattttcat tgatataaat acttgtacat atgatttgta cttctgctgt gagattccct     2340

agtgtcaaaa ttaaatcaat aaaactgagc atttgtctaa aaaaaaaaaa aaaaaaaaaa     2400

aaaaa                                                                 2405


<210>  3
<211>  728
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Gly Phe Trp Val Gly Thr Ala Pro Leu Val Ala Ala Gly Arg 
1               5                   10                  15      


Arg Gly Arg Trp Pro Pro Gln Gln Leu Met Leu Ser Ala Ala Leu Arg 
            20                  25                  30          


Thr Leu Lys His Val Leu Tyr Tyr Ser Arg Gln Cys Leu Met Val Ser 
        35                  40                  45              


Arg Asn Leu Gly Ser Val Gly Tyr Asp Pro Asn Glu Lys Thr Phe Asp 
    50                  55                  60                  


Lys Ile Leu Val Ala Asn Arg Gly Glu Ile Ala Cys Arg Val Ile Arg 
65                  70                  75                  80  


Thr Cys Lys Lys Met Gly Ile Lys Thr Val Ala Ile His Ser Asp Val 
                85                  90                  95      


Asp Ala Ser Ser Val His Val Lys Met Ala Asp Glu Ala Val Cys Val 
            100                 105                 110         


Gly Pro Ala Pro Thr Ser Lys Ser Tyr Leu Asn Met Asp Ala Ile Met 
        115                 120                 125             


Glu Ala Ile Lys Lys Thr Arg Ala Gln Ala Val His Pro Gly Tyr Gly 
    130                 135                 140                 


Phe Leu Ser Glu Asn Lys Glu Phe Ala Arg Cys Leu Ala Ala Glu Asp 
145                 150                 155                 160 


Val Val Phe Ile Gly Pro Asp Thr His Ala Ile Gln Ala Met Gly Asp 
                165                 170                 175     


Lys Ile Glu Ser Lys Leu Leu Ala Lys Lys Ala Glu Val Asn Thr Ile 
            180                 185                 190         


Pro Gly Phe Asp Gly Val Val Lys Asp Ala Glu Glu Ala Val Arg Ile 
        195                 200                 205             


Ala Arg Glu Ile Gly Tyr Pro Val Met Ile Lys Ala Ser Ala Gly Gly 
    210                 215                 220                 


Gly Gly Lys Gly Met Arg Ile Ala Trp Asp Asp Glu Glu Thr Arg Asp 
225                 230                 235                 240 


Gly Phe Arg Leu Ser Ser Gln Glu Ala Ala Ser Ser Phe Gly Asp Asp 
                245                 250                 255     


Arg Leu Leu Ile Glu Lys Phe Ile Asp Asn Pro Arg His Ile Glu Ile 
            260                 265                 270         


Gln Val Leu Gly Asp Lys His Gly Asn Ala Leu Trp Leu Asn Glu Arg 
        275                 280                 285             


Glu Cys Ser Ile Gln Arg Arg Asn Gln Lys Val Val Glu Glu Ala Pro 
    290                 295                 300                 


Ser Ile Phe Leu Asp Ala Glu Thr Arg Arg Ala Met Gly Glu Gln Ala 
305                 310                 315                 320 


Val Ala Leu Ala Arg Ala Val Lys Tyr Ser Ser Ala Gly Thr Val Glu 
                325                 330                 335     


Phe Leu Val Asp Ser Lys Lys Asn Phe Tyr Phe Leu Glu Met Asn Thr 
            340                 345                 350         


Arg Leu Gln Val Glu His Pro Val Thr Glu Cys Ile Thr Gly Leu Asp 
        355                 360                 365             


Leu Val Gln Glu Met Ile Arg Val Ala Lys Gly Tyr Pro Leu Arg His 
    370                 375                 380                 


Lys Gln Ala Asp Ile Arg Ile Asn Gly Trp Ala Val Glu Cys Arg Val 
385                 390                 395                 400 


Tyr Ala Glu Asp Pro Tyr Lys Ser Phe Gly Leu Pro Ser Ile Gly Arg 
                405                 410                 415     


Leu Ser Gln Tyr Gln Glu Pro Leu His Leu Pro Gly Val Arg Val Asp 
            420                 425                 430         


Ser Gly Ile Gln Pro Gly Ser Asp Ile Ser Ile Tyr Tyr Asp Pro Met 
        435                 440                 445             


Ile Ser Lys Leu Ile Thr Tyr Gly Ser Asp Arg Thr Glu Ala Leu Lys 
    450                 455                 460                 


Arg Met Ala Asp Ala Leu Asp Asn Tyr Val Ile Arg Gly Val Thr His 
465                 470                 475                 480 


Asn Ile Ala Leu Leu Arg Glu Val Ile Ile Asn Ser Arg Phe Val Lys 
                485                 490                 495     


Gly Asp Ile Ser Thr Lys Phe Leu Ser Asp Val Tyr Pro Asp Gly Phe 
            500                 505                 510         


Lys Gly His Met Leu Thr Lys Ser Glu Lys Asn Gln Leu Leu Ala Ile 
        515                 520                 525             


Ala Ser Ser Leu Phe Val Ala Phe Gln Leu Arg Ala Gln His Phe Gln 
    530                 535                 540                 


Glu Asn Ser Arg Met Pro Val Ile Lys Pro Asp Ile Ala Asn Trp Glu 
545                 550                 555                 560 


Leu Ser Val Lys Leu His Asp Lys Val His Thr Val Val Ala Ser Asn 
                565                 570                 575     


Asn Gly Ser Val Phe Ser Val Glu Val Asp Gly Ser Lys Leu Asn Val 
            580                 585                 590         


Thr Ser Thr Trp Asn Leu Ala Ser Pro Leu Leu Ser Val Ser Val Asp 
        595                 600                 605             


Gly Thr Gln Arg Thr Val Gln Cys Leu Ser Arg Glu Ala Gly Gly Asn 
    610                 615                 620                 


Met Ser Ile Gln Phe Leu Gly Thr Val Tyr Lys Val Asn Ile Leu Thr 
625                 630                 635                 640 


Arg Leu Ala Ala Glu Leu Asn Lys Phe Met Leu Glu Lys Val Thr Glu 
                645                 650                 655     


Asp Thr Ser Ser Val Leu Arg Ser Pro Met Pro Gly Val Val Val Ala 
            660                 665                 670         


Val Ser Val Lys Pro Gly Asp Ala Val Ala Glu Gly Gln Glu Ile Cys 
        675                 680                 685             


Val Ile Glu Ala Met Lys Met Gln Asn Ser Met Thr Ala Gly Lys Thr 
    690                 695                 700                 


Gly Thr Val Lys Ser Val His Cys Gln Ala Gly Asp Thr Val Gly Glu 
705                 710                 715                 720 


Gly Asp Leu Leu Val Glu Leu Glu 
                725             


<210>  4
<211>  703
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Leu Ser Ala Ala Leu Arg Thr Leu Lys His Val Leu Tyr Tyr Ser 
1               5                   10                  15      


Arg Gln Cys Leu Met Val Ser Arg Asn Leu Gly Ser Val Gly Tyr Asp 
            20                  25                  30          


Pro Asn Glu Lys Thr Phe Asp Lys Ile Leu Val Ala Asn Arg Gly Glu 
        35                  40                  45              


Ile Ala Cys Arg Val Ile Arg Thr Cys Lys Lys Met Gly Ile Lys Thr 
    50                  55                  60                  


Val Ala Ile His Ser Asp Val Asp Ala Ser Ser Val His Val Lys Met 
65                  70                  75                  80  


Ala Asp Glu Ala Val Cys Val Gly Pro Ala Pro Thr Ser Lys Ser Tyr 
                85                  90                  95      


Leu Asn Met Asp Ala Ile Met Glu Ala Ile Lys Lys Thr Arg Ala Gln 
            100                 105                 110         


Ala Val His Pro Gly Tyr Gly Phe Leu Ser Glu Asn Lys Glu Phe Ala 
        115                 120                 125             


Arg Cys Leu Ala Ala Glu Asp Val Val Phe Ile Gly Pro Asp Thr His 
    130                 135                 140                 


Ala Ile Gln Ala Met Gly Asp Lys Ile Glu Ser Lys Leu Leu Ala Lys 
145                 150                 155                 160 


Lys Ala Glu Val Asn Thr Ile Pro Gly Phe Asp Gly Val Val Lys Asp 
                165                 170                 175     


Ala Glu Glu Ala Val Arg Ile Ala Arg Glu Ile Gly Tyr Pro Val Met 
            180                 185                 190         


Ile Lys Ala Ser Ala Gly Gly Gly Gly Lys Gly Met Arg Ile Ala Trp 
        195                 200                 205             


Asp Asp Glu Glu Thr Arg Asp Gly Phe Arg Leu Ser Ser Gln Glu Ala 
    210                 215                 220                 


Ala Ser Ser Phe Gly Asp Asp Arg Leu Leu Ile Glu Lys Phe Ile Asp 
225                 230                 235                 240 


Asn Pro Arg His Ile Glu Ile Gln Val Leu Gly Asp Lys His Gly Asn 
                245                 250                 255     


Ala Leu Trp Leu Asn Glu Arg Glu Cys Ser Ile Gln Arg Arg Asn Gln 
            260                 265                 270         


Lys Val Val Glu Glu Ala Pro Ser Ile Phe Leu Asp Ala Glu Thr Arg 
        275                 280                 285             


Arg Ala Met Gly Glu Gln Ala Val Ala Leu Ala Arg Ala Val Lys Tyr 
    290                 295                 300                 


Ser Ser Ala Gly Thr Val Glu Phe Leu Val Asp Ser Lys Lys Asn Phe 
305                 310                 315                 320 


Tyr Phe Leu Glu Met Asn Thr Arg Leu Gln Val Glu His Pro Val Thr 
                325                 330                 335     


Glu Cys Ile Thr Gly Leu Asp Leu Val Gln Glu Met Ile Arg Val Ala 
            340                 345                 350         


Lys Gly Tyr Pro Leu Arg His Lys Gln Ala Asp Ile Arg Ile Asn Gly 
        355                 360                 365             


Trp Ala Val Glu Cys Arg Val Tyr Ala Glu Asp Pro Tyr Lys Ser Phe 
    370                 375                 380                 


Gly Leu Pro Ser Ile Gly Arg Leu Ser Gln Tyr Gln Glu Pro Leu His 
385                 390                 395                 400 


Leu Pro Gly Val Arg Val Asp Ser Gly Ile Gln Pro Gly Ser Asp Ile 
                405                 410                 415     


Ser Ile Tyr Tyr Asp Pro Met Ile Ser Lys Leu Ile Thr Tyr Gly Ser 
            420                 425                 430         


Asp Arg Thr Glu Ala Leu Lys Arg Met Ala Asp Ala Leu Asp Asn Tyr 
        435                 440                 445             


Val Ile Arg Gly Val Thr His Asn Ile Ala Leu Leu Arg Glu Val Ile 
    450                 455                 460                 


Ile Asn Ser Arg Phe Val Lys Gly Asp Ile Ser Thr Lys Phe Leu Ser 
465                 470                 475                 480 


Asp Val Tyr Pro Asp Gly Phe Lys Gly His Met Leu Thr Lys Ser Glu 
                485                 490                 495     


Lys Asn Gln Leu Leu Ala Ile Ala Ser Ser Leu Phe Val Ala Phe Gln 
            500                 505                 510         


Leu Arg Ala Gln His Phe Gln Glu Asn Ser Arg Met Pro Val Ile Lys 
        515                 520                 525             


Pro Asp Ile Ala Asn Trp Glu Leu Ser Val Lys Leu His Asp Lys Val 
    530                 535                 540                 


His Thr Val Val Ala Ser Asn Asn Gly Ser Val Phe Ser Val Glu Val 
545                 550                 555                 560 


Asp Gly Ser Lys Leu Asn Val Thr Ser Thr Trp Asn Leu Ala Ser Pro 
                565                 570                 575     


Leu Leu Ser Val Ser Val Asp Gly Thr Gln Arg Thr Val Gln Cys Leu 
            580                 585                 590         


Ser Arg Glu Ala Gly Gly Asn Met Ser Ile Gln Phe Leu Gly Thr Val 
        595                 600                 605             


Tyr Lys Val Asn Ile Leu Thr Arg Leu Ala Ala Glu Leu Asn Lys Phe 
    610                 615                 620                 


Met Leu Glu Lys Val Thr Glu Asp Thr Ser Ser Val Leu Arg Ser Pro 
625                 630                 635                 640 


Met Pro Gly Val Val Val Ala Val Ser Val Lys Pro Gly Asp Ala Val 
                645                 650                 655     


Ala Glu Gly Gln Glu Ile Cys Val Ile Glu Ala Met Lys Met Gln Asn 
            660                 665                 670         


Ser Met Thr Ala Gly Lys Thr Gly Thr Val Lys Ser Val His Cys Gln 
        675                 680                 685             


Ala Gly Asp Thr Val Gly Glu Gly Asp Leu Leu Val Glu Leu Glu 
    690                 695                 700             


<210>  5
<211>  1620
<212>  DNA
<213>  Homo sapiens

<400>  5
atggcggcgg cattacgggt ggcggcggtc ggggcaaggc tcagcgttct ggcgagcggt       60

ctccgcgccg cggtccgcag cctttgcagc caggccacct ctgttaacga acgcatcgaa      120

aacaagcgcc ggaccgcgct gctgggaggg ggccaacgcc gtattgacgc gcagcacaag      180

cgaggaaagc taacagccag ggagaggatc agtctcttgc tggaccctgg cagctttgtt      240

gagagcgaca tgtttgtgga acacagatgt gcagattttg gaatggctgc tgataagaat      300

aagtttcctg gagacagcgt ggtcactgga cgaggccgaa tcaatggaag attggtttat      360

gtcttcagtc aggattttac agtttttgga ggcagtctgt caggagcaca tgcccaaaag      420

atctgcaaaa tcatggacca ggccataacg gtgggggctc cagtgattgg gctgaatgac      480

tctgggggag cacggatcca agaaggagtg gagtctttgg ctggctatgc agacatcttt      540

ctgaggaatg ttacggcatc cggagtcatc cctcagattt ctctgatcat gggcccatgt      600

gctggtgggg ccgtctactc cccagcccta acagacttca cgttcatggt aaaggacacc      660

tcctacctgt tcatcactgg ccctgatgtt gtgaagtctg tcaccaatga ggatgttacc      720

caggaggagc tcggtggtgc caagacccac accaccatgt caggtgtggc ccacagagct      780

tttgaaaatg atgttgatgc cttgtgtaat ctccgggatt tcttcaacta cctgcccctg      840

agcagtcagg acccggctcc cgtccgtgag tgccacgatc ccagtgaccg tctggttcct      900

gagcttgaca caattgtccc tttggaatca accaaagcct acaacatggt ggacatcata      960

cactctgttg ttgatgagcg tgaatttttt gagatcatgc ccaattatgc caagaacatc     1020

attgttggtt ttgcaagaat gaatgggagg actgttggaa ttgttggcaa ccaacctaag     1080

gtggcctcag gatgcttgga tattaattca tctgtgaaag gggctcgttt tgtcagattc     1140

tgtgatgcat tcaatattcc actcatcact tttgttgatg tccctggctt tctacctggc     1200

acagcacagg aatacggggg catcatccgg catggtgcca agcttctcta cgcatttgct     1260

gaggcaactg tacccaaagt cacagtcatc accaggaagg cctatggagg tgcctatgat     1320

gtcatgagct ctaagcacct ttgtggtgat accaactatg cctggcccac cgcagagatt     1380

gcagtcatgg gagcaaaggg cgctgtggag atcatcttca aagggcatga gaatgtggaa     1440

gctgctcagg cagagtacat cgagaagttt gccaaccctt tccctgcagc agtgcgaggg     1500

tttgtggatg acatcatcca accttcttcc acacgtgccc gaatctgctg tgacctggat     1560

gtcttggcca gcaagaaggt acaacgtcct tggagaaaac atgcaaatat tccattgtaa     1620


<210>  6
<211>  539
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Ala Ala Leu Arg Val Ala Ala Val Gly Ala Arg Leu Ser Val 
1               5                   10                  15      


Leu Ala Ser Gly Leu Arg Ala Ala Val Arg Ser Leu Cys Ser Gln Ala 
            20                  25                  30          


Thr Ser Val Asn Glu Arg Ile Glu Asn Lys Arg Arg Thr Ala Leu Leu 
        35                  40                  45              


Gly Gly Gly Gln Arg Arg Ile Asp Ala Gln His Lys Arg Gly Lys Leu 
    50                  55                  60                  


Thr Ala Arg Glu Arg Ile Ser Leu Leu Leu Asp Pro Gly Ser Phe Val 
65                  70                  75                  80  


Glu Ser Asp Met Phe Val Glu His Arg Cys Ala Asp Phe Gly Met Ala 
                85                  90                  95      


Ala Asp Lys Asn Lys Phe Pro Gly Asp Ser Val Val Thr Gly Arg Gly 
            100                 105                 110         


Arg Ile Asn Gly Arg Leu Val Tyr Val Phe Ser Gln Asp Phe Thr Val 
        115                 120                 125             


Phe Gly Gly Ser Leu Ser Gly Ala His Ala Gln Lys Ile Cys Lys Ile 
    130                 135                 140                 


Met Asp Gln Ala Ile Thr Val Gly Ala Pro Val Ile Gly Leu Asn Asp 
145                 150                 155                 160 


Ser Gly Gly Ala Arg Ile Gln Glu Gly Val Glu Ser Leu Ala Gly Tyr 
                165                 170                 175     


Ala Asp Ile Phe Leu Arg Asn Val Thr Ala Ser Gly Val Ile Pro Gln 
            180                 185                 190         


Ile Ser Leu Ile Met Gly Pro Cys Ala Gly Gly Ala Val Tyr Ser Pro 
        195                 200                 205             


Ala Leu Thr Asp Phe Thr Phe Met Val Lys Asp Thr Ser Tyr Leu Phe 
    210                 215                 220                 


Ile Thr Gly Pro Asp Val Val Lys Ser Val Thr Asn Glu Asp Val Thr 
225                 230                 235                 240 


Gln Glu Glu Leu Gly Gly Ala Lys Thr His Thr Thr Met Ser Gly Val 
                245                 250                 255     


Ala His Arg Ala Phe Glu Asn Asp Val Asp Ala Leu Cys Asn Leu Arg 
            260                 265                 270         


Asp Phe Phe Asn Tyr Leu Pro Leu Ser Ser Gln Asp Pro Ala Pro Val 
        275                 280                 285             


Arg Glu Cys His Asp Pro Ser Asp Arg Leu Val Pro Glu Leu Asp Thr 
    290                 295                 300                 


Ile Val Pro Leu Glu Ser Thr Lys Ala Tyr Asn Met Val Asp Ile Ile 
305                 310                 315                 320 


His Ser Val Val Asp Glu Arg Glu Phe Phe Glu Ile Met Pro Asn Tyr 
                325                 330                 335     


Ala Lys Asn Ile Ile Val Gly Phe Ala Arg Met Asn Gly Arg Thr Val 
            340                 345                 350         


Gly Ile Val Gly Asn Gln Pro Lys Val Ala Ser Gly Cys Leu Asp Ile 
        355                 360                 365             


Asn Ser Ser Val Lys Gly Ala Arg Phe Val Arg Phe Cys Asp Ala Phe 
    370                 375                 380                 


Asn Ile Pro Leu Ile Thr Phe Val Asp Val Pro Gly Phe Leu Pro Gly 
385                 390                 395                 400 


Thr Ala Gln Glu Tyr Gly Gly Ile Ile Arg His Gly Ala Lys Leu Leu 
                405                 410                 415     


Tyr Ala Phe Ala Glu Ala Thr Val Pro Lys Val Thr Val Ile Thr Arg 
            420                 425                 430         


Lys Ala Tyr Gly Gly Ala Tyr Asp Val Met Ser Ser Lys His Leu Cys 
        435                 440                 445             


Gly Asp Thr Asn Tyr Ala Trp Pro Thr Ala Glu Ile Ala Val Met Gly 
    450                 455                 460                 


Ala Lys Gly Ala Val Glu Ile Ile Phe Lys Gly His Glu Asn Val Glu 
465                 470                 475                 480 


Ala Ala Gln Ala Glu Tyr Ile Glu Lys Phe Ala Asn Pro Phe Pro Ala 
                485                 490                 495     


Ala Val Arg Gly Phe Val Asp Asp Ile Ile Gln Pro Ser Ser Thr Arg 
            500                 505                 510         


Ala Arg Ile Cys Cys Asp Leu Asp Val Leu Ala Ser Lys Lys Val Gln 
        515                 520                 525             


Arg Pro Trp Arg Lys His Ala Asn Ile Pro Leu 
    530                 535                 


<210>  7
<211>  4036
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  7
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgca cgcgtctagt tattaatagt aatcaattac      180

ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta cggtaaatgg      240

cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc      300

catagtaacg tcaataggga ctttccattg acgtcaatgg gtggagtatt tacggtaaac      360

tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa      420

tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac      480

ttggcagtac atctacgtat tagtcatcgc tattaccatg gtcgaggtga gccccacgtt      540

ctgcttcact ctccccatct cccccccctc cccaccccca attttgtatt tatttatttt      600

ttaattattt tgtgcagcga tgggggcggg gggggggggg gggcgcgcgc caggcggggc      660

ggggcggggc gaggggcggg gcggggcgag gcggagaggt gcggcggcag ccaatcagag      720

cggcgcgctc cgaaagtttc cttttatggc gaggcggcgg cggcggcggc cctataaaaa      780

gcgaagcgcg cggcgggcgg gagtcgctgc gacgctgcct tcgccccgtg ccccgctccg      840

ccgccgcctc gcgccgcccg ccccggctct gactgaccgc gttactccca caggtgagcg      900

ggcgggacgg cccttctcct ccgggctgta attagctgag caagaggtaa gggtttaagg      960

gatggttggt tggtggggta ttaatgttta attacctgga gcacctgcct gaaatcactt     1020

tttttcaggt tggacgaatt cgagctcggt acctcgcgaa tgcatctaga tccaatagat     1080

ctgacgatgg ccggcttctg ggtgggcacc gcccccctgg tggccgccgg ccgccgcggc     1140

cgctggcccc cccagcagct gatgctgagc gccgccctgc gcaccctgaa gcacgtgctg     1200

tactacagcc gccagtgcct gatggtgagc cgcaacctgg gcagcgtggg ctacgacccc     1260

aacgagaaga ccttcgacaa gatcctggtg gccaaccgcg gcgagatcgc ctgccgcgtg     1320

atccgcacct gcaagaagat gggcatcaag accgtggcca tccacagcga cgtggacgcc     1380

agcagcgtgc acgtgaagat ggccgacgag gccgtgtgcg tgggccccgc ccccaccagc     1440

aagagctacc tgaacatgga cgccatcatg gaggccatca agaagacccg cgcccaggcc     1500

gtgcaccccg gctacggctt cctgagcgag aacaaggagt tcgcccgctg cctggccgcc     1560

gaggacgtgg tgttcatcgg ccccgacacc cacgccatcc aggccatggg cgacaagatc     1620

gagagcaagc tgctggccaa gaaggccgag gtgaacacca tccccggctt cgacggcgtg     1680

gtgaaggacg ccgaggaggc cgtgcgcatc gcccgcgaga tcggctaccc cgtgatgatc     1740

aaggccagcg ccggcggcgg cggcaagggc atgcgcatcg cctgggacga cgaggagacc     1800

cgcgacggct tccgcctgag cagccaggag gccgccagca gcttcggcga cgaccgcctg     1860

ctgatcgaga agttcatcga caacccccgc cacatcgaga tccaggtgct gggcgacaag     1920

cacggcaacg ccctgtggct gaacgagcgc gagtgcagca tccagcgccg caaccagaag     1980

gtggtggagg aggcccccag catcttcctg gacgccgaga cccgccgcgc catgggcgag     2040

caggccgtgg ccctggcccg cgccgtgaag tacagcagcg ccggcaccgt ggagttcctg     2100

gtggacagca agaagaactt ctacttcctg gagatgaaca cccgcctgca ggtggagcac     2160

cccgtgaccg agtgcatcac cggcctggac ctggtgcagg agatgatccg cgtggccaag     2220

ggctaccccc tgcgccacaa gcaggccgac atccgcatca acggctgggc cgtggagtgc     2280

cgcgtgtacg ccgaggaccc ctacaagagc ttcggcctgc ccagcatcgg ccgcctgagc     2340

cagtaccagg agcccctgca cctgcccggc gtgcgcgtgg acagcggcat ccagcccggc     2400

agcgacatca gcatctacta cgaccccatg atcagcaagc tgatcaccta cggcagcgac     2460

cgcaccgagg ccctgaagcg catggccgac gccctggaca actacgtgat ccgcggcgtg     2520

acccacaaca tcgccctgct gcgcgaggtg atcatcaaca gccgcttcgt gaagggcgac     2580

atcagcacca agttcctgag cgacgtgtac cccgacggct tcaagggcca catgctgacc     2640

aagagcgaga agaaccagct gctggccatc gccagcagcc tgttcgtggc cttccagctg     2700

cgcgcccagc acttccagga gaacagccgc atgcccgtga tcaagcccga catcgccaac     2760

tgggagctga gcgtgaagct gcacgacaag gtgcacaccg tggtggccag caacaacggc     2820

agcgtgttca gcgtggaggt ggacggcagc aagctgaacg tgaccagcac ctggaacctg     2880

gccagccccc tgctgagcgt gagcgtggac ggcacccagc gcaccgtgca gtgcctgagc     2940

cgcgaggccg gcggcaacat gagcatccag ttcctgggca ccgtgtacaa ggtgaacatc     3000

ctgacccgcc tggccgccga gctgaacaag ttcatgctgg agaaggtgac cgaggacacc     3060

agcagcgtgc tgcgcagccc catgcccggc gtggtggtgg ccgtgagcgt gaagcccggc     3120

gacgccgtgg ccgagggcca ggagatctgc gtgatcgagg ccatgaagat gcagaacagc     3180

atgaccgccg gcaagaccgg caccgtgaag agcgtgcact gccaggccgg cgacaccgtg     3240

ggcgagggcg acctgctggt ggagctggag tgagcggccg cagtactgct agcactagta     3300

ttggatcgga tcccgggccc gtcgactgca gaggcctgca tgcaagcttg cctcgagcag     3360

cgctgctcga gagatctacg ggtggcatcc ctgtgacccc tccccagtgc ctctcctggc     3420

cctggaagtt gccactccag tgcccaccag ccttgtccta ataaaattaa gttgcatcat     3480

tttgtctgac taggtgtcct tctataatat tatggggtgg aggggggtgg tatggagcaa     3540

ggggcaagtt gggaagacaa cctgtagggc ctgcggggtc tattgggaac caagctggag     3600

tgcagtggca caatcttggc tcactgcaat ctccgcctcc tgggttcaag cgattctcct     3660

gcctcagcct cccgagttgt tgggattcca ggcatgcatg accaggctca gctaattttt     3720

gtttttttgg tagagacggg gtttcaccat attggccagg ctggtctcca actcctaatc     3780

tcaggtgatc tacccacctt ggcctcccaa attgctggga ttacaggcgt gaaccactgc     3840

tcccttccct gtccttctga ttttgtaggt aaccacgtgc ggaccgagcg gccgcaggaa     3900

cccctagtga tggagttggc cactccctct ctgcgcgctc gctcgctcac tgaggccggg     3960

cgaccaaagg tcgcccgacg cccgggcttt gcccgggcgg cctcagtgag cgagcgagcg     4020

cgcagctgcc tgcagg                                                     4036


<210>  8
<211>  4025
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  8
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtctagtt attaatagta atcaattacg gggtcattag      180

ttcatagccc atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct      240

gaccgcccaa cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc      300

caatagggac tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg      360

cagtacatca agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat      420

ggcccgcctg gcattgtgcc cagtacatga ccttatggga ctttcctact tggcagtaca      480

tctacgtatt agtcatcgct attaccatgg tcgaggtgag ccccacgttc tgcttcactc      540

tccccatctc ccccccctcc ccacccccaa ttttgtattt atttattttt taattatttt      600

gtgcagcgat gggggcgggg gggggggggg gggcgcgcgc caggcggggc ggggcggggc      660

gaggggcggg gcggggcgag gcggagaggt gcggcggcag ccaatcagag cggcgcgctc      720

cgaaagtttc cttttatggc gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg      780

cggcgggcgg gagtcgctgc gcgctgcctt cgccccgtgc cccgctccgc cgccgcctcg      840

cgccgcccgc cccggctctg actgaccgcg ttactcccac aggtgagcgg gcgggacggc      900

ccttctcctc cgggctgtaa ttagctgagc aagaggtaag ggtttaaggg atggttggtt      960

ggtggggtat taatgtttaa ttacctggag cacctgcctg aaatcacttt ttttcaggtt     1020

ggacgaattc gagctcggta cctcgcgaat gcatctagat ccaatagatc tgacgatggc     1080

cggcttctgg gtgggcaccg cccccctggt ggccgccggc cgccgcggcc gctggccccc     1140

ccagcagctg atgctgagcg ccgccctgcg caccctgaag cacgtgctgt actacagccg     1200

ccagtgcctg atggtgagcc gcaacctggg cagcgtgggc tacgacccca acgagaagac     1260

cttcgacaag atcctggtgg ccaaccgcgg cgagatcgcc tgccgcgtga tccgcacctg     1320

caagaagatg ggcatcaaga ccgtggccat ccacagcgac gtggacgcca gcagcgtgca     1380

cgtgaagatg gccgacgagg ccgtgtgcgt gggccccgcc cccaccagca agagctacct     1440

gaacatggac gccatcatgg aggccatcaa gaagacccgc gcccaggccg tgcaccccgg     1500

ctacggcttc ctgagcgaga acaaggagtt cgcccgctgc ctggccgccg aggacgtggt     1560

gttcatcggc cccgacaccc acgccatcca ggccatgggc gacaagatcg agagcaagct     1620

gctggccaag aaggccgagg tgaacaccat ccccggcttc gacggcgtgg tgaaggacgc     1680

cgaggaggcc gtgcgcatcg cccgcgagat cggctacccc gtgatgatca aggccagcgc     1740

cggcggcggc ggcaagggca tgcgcatcgc ctgggacgac gaggagaccc gcgacggctt     1800

ccgcctgagc agccaggagg ccgccagcag cttcggcgac gaccgcctgc tgatcgagaa     1860

gttcatcgac aacccccgcc acatcgagat ccaggtgctg ggcgacaagc acggcaacgc     1920

cctgtggctg aacgagcgcg agtgcagcat ccagcgccgc aaccagaagg tggtggagga     1980

ggcccccagc atcttcctgg acgccgagac ccgccgcgcc atgggcgagc aggccgtggc     2040

cctggcccgc gccgtgaagt acagcagcgc cggcaccgtg gagttcctgg tggacagcaa     2100

gaagaacttc tacttcctgg agatgaacac ccgcctgcag gtggagcacc ccgtgaccga     2160

gtgcatcacc ggcctggacc tggtgcagga gatgatccgc gtggccaagg gctaccccct     2220

gcgccacaag caggccgaca tccgcatcaa cggctgggcc gtggagtgcc gcgtgtacgc     2280

cgaggacccc tacaagagct tcggcctgcc cagcatcggc cgcctgagcc agtaccagga     2340

gcccctgcac ctgcccggcg tgcgcgtgga cagcggcatc cagcccggca gcgacatcag     2400

catctactac gaccccatga tcagcaagct gatcacctac ggcagcgacc gcaccgaggc     2460

cctgaagcgc atggccgacg ccctggacaa ctacgtgatc cgcggcgtga cccacaacat     2520

cgccctgctg cgcgaggtga tcatcaacag ccgcttcgtg aagggcgaca tcagcaccaa     2580

gttcctgagc gacgtgtacc ccgacggctt caagggccac atgctgacca agagcgagaa     2640

gaaccagctg ctggccatcg ccagcagcct gttcgtggcc ttccagctgc gcgcccagca     2700

cttccaggag aacagccgca tgcccgtgat caagcccgac atcgccaact gggagctgag     2760

cgtgaagctg cacgacaagg tgcacaccgt ggtggccagc aacaacggca gcgtgttcag     2820

cgtggaggtg gacggcagca agctgaacgt gaccagcacc tggaacctgg ccagccccct     2880

gctgagcgtg agcgtggacg gcacccagcg caccgtgcag tgcctgagcc gcgaggccgg     2940

cggcaacatg agcatccagt tcctgggcac cgtgtacaag gtgaacatcc tgacccgcct     3000

ggccgccgag ctgaacaagt tcatgctgga gaaggtgacc gaggacacca gcagcgtgct     3060

gcgcagcccc atgcccggcg tggtggtggc cgtgagcgtg aagcccggcg acgccgtggc     3120

cgagggccag gagatctgcg tgatcgaggc catgaagatg cagaacagca tgaccgccgg     3180

caagaccggc accgtgaaga gcgtgcactg ccaggccggc gacaccgtgg gcgagggcga     3240

cctgctggtg gagctggagt gagcggccgc agtactgcta gcactagtat tggatcggat     3300

cccgggcccg tcgactgcag aggcctgcat gcaagcttgc ctcgagcagc gctgctcgag     3360

agatctacgg gtggcatccc tgtgacccct ccccagtgcc tctcctggcc ctggaagttg     3420

ccactccagt gcccaccagc cttgtcctaa taaaattaag ttgcatcatt ttgtctgact     3480

aggtgtcctt ctataatatt atggggtgga ggggggtggt atggagcaag gggcaagttg     3540

ggaagacaac ctgtagggcc tgcggggtct attgggaacc aagctggagt gcagtggcac     3600

aatcttggct cactgcaatc tccgcctcct gggttcaagc gattctcctg cctcagcctc     3660

ccgagttgtt gggattccag gcatgcatga ccaggctcag ctaatttttg tttttttggt     3720

agagacgggg tttcaccata ttggccaggc tggtctccaa ctcctaatct caggtgatct     3780

acccaccttg gcctcccaaa ttgctgggat tacaggcgtg aaccactgct cccttccctg     3840

tccttctgat tttgtaggta accacgtgcg gaccgagcgg ccgcaggaac ccctagtgat     3900

ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt     3960

cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gcagctgcct     4020

gcagg                                                                 4025


<210>  9
<211>  1227
<212>  DNA
<213>  Homo sapiens

<400>  9
atgcaggtca ccctgaagac cctccagcag cagaccttca agatagacat tgaccccgag       60

gagacggtga aagcactgaa agagaagatt gaatctgaaa aggggaaaga tgcctttcca      120

gtagcaggtc aaaaattaat ttatgcaggc aaaatcctca atgatgatac tgctctcaaa      180

gaatataaaa ttgatgagaa aaactttgtg gtggttatgg tgaccaaacc caaagcagtg      240

tccacaccag caccagctac aactcagcag tcagctcctg ccagcactac agcagttact      300

tcctccacca ccacaactgt ggctcaggct ccaacccctg tccctgcctt ggcccccact      360

tccacacctg catccatcac tccagcatca gcgacagcat cttctgaacc tgcacctgct      420

agtgcagcta aacaagagaa gcctgcagaa aagccagcag agacaccagt ggctactagc      480

ccaacagcaa ctgacagtac atcgggtgat tcttctcggt caaacctttt tgaagatgca      540

acgagtgcac ttgtgacggg tcagtcttac gagaatatgg taactgagat catgtcaatg      600

ggctatgaac gagagcaagt aattgcagcc ctgagagcca gtttcaacaa ccctgacaga      660

gcagtggagt atcttttaat gggaatccct ggagatagag aaagtcaggc tgtggttgac      720

ccccctcaag cagctagtac tggggctcct cagtcttcag cagtggctgc agctgcagca      780

actacgacag caacaactac aacaacaagt tctggaggac atccccttga atttttacgg      840

aatcagcctc agtttcaaca gatgagacaa attattcagc agaatccttc cttgcttcca      900

gcgttactac agcagatagg tcgagagaat cctcaattac ttcagcaaat tagccaacac      960

caggagcatt ttattcagat gttaaatgaa ccagttcaag aagctggtgg tcaaggagga     1020

ggaggtggag gtggcagtgg aggaattgca gaagctggaa gtggtcatat gaactacatt     1080

caagtaacac ctcaggaaaa agaagctata gaaaggttaa aggcattagg atttcctgaa     1140

ggacttgtga tacaagcgta ttttgcttgt gagaagaatg agaatttggc tgccaatttt     1200

cttctacagc agaactttga tgaagat                                         1227


<210>  10
<211>  409
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gln Val Thr Leu Lys Thr Leu Gln Gln Gln Thr Phe Lys Ile Asp 
1               5                   10                  15      


Ile Asp Pro Glu Glu Thr Val Lys Ala Leu Lys Glu Lys Ile Glu Ser 
            20                  25                  30          


Glu Lys Gly Lys Asp Ala Phe Pro Val Ala Gly Gln Lys Leu Ile Tyr 
        35                  40                  45              


Ala Gly Lys Ile Leu Asn Asp Asp Thr Ala Leu Lys Glu Tyr Lys Ile 
    50                  55                  60                  


Asp Glu Lys Asn Phe Val Val Val Met Val Thr Lys Pro Lys Ala Val 
65                  70                  75                  80  


Ser Thr Pro Ala Pro Ala Thr Thr Gln Gln Ser Ala Pro Ala Ser Thr 
                85                  90                  95      


Thr Ala Val Thr Ser Ser Thr Thr Thr Thr Val Ala Gln Ala Pro Thr 
            100                 105                 110         


Pro Val Pro Ala Leu Ala Pro Thr Ser Thr Pro Ala Ser Ile Thr Pro 
        115                 120                 125             


Ala Ser Ala Thr Ala Ser Ser Glu Pro Ala Pro Ala Ser Ala Ala Lys 
    130                 135                 140                 


Gln Glu Lys Pro Ala Glu Lys Pro Ala Glu Thr Pro Val Ala Thr Ser 
145                 150                 155                 160 


Pro Thr Ala Thr Asp Ser Thr Ser Gly Asp Ser Ser Arg Ser Asn Leu 
                165                 170                 175     


Phe Glu Asp Ala Thr Ser Ala Leu Val Thr Gly Gln Ser Tyr Glu Asn 
            180                 185                 190         


Met Val Thr Glu Ile Met Ser Met Gly Tyr Glu Arg Glu Gln Val Ile 
        195                 200                 205             


Ala Ala Leu Arg Ala Ser Phe Asn Asn Pro Asp Arg Ala Val Glu Tyr 
    210                 215                 220                 


Leu Leu Met Gly Ile Pro Gly Asp Arg Glu Ser Gln Ala Val Val Asp 
225                 230                 235                 240 


Pro Pro Gln Ala Ala Ser Thr Gly Ala Pro Gln Ser Ser Ala Val Ala 
                245                 250                 255     


Ala Ala Ala Ala Thr Thr Thr Ala Thr Thr Thr Thr Thr Ser Ser Gly 
            260                 265                 270         


Gly His Pro Leu Glu Phe Leu Arg Asn Gln Pro Gln Phe Gln Gln Met 
        275                 280                 285             


Arg Gln Ile Ile Gln Gln Asn Pro Ser Leu Leu Pro Ala Leu Leu Gln 
    290                 295                 300                 


Gln Ile Gly Arg Glu Asn Pro Gln Leu Leu Gln Gln Ile Ser Gln His 
305                 310                 315                 320 


Gln Glu His Phe Ile Gln Met Leu Asn Glu Pro Val Gln Glu Ala Gly 
                325                 330                 335     


Gly Gln Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly Ile Ala Glu Ala 
            340                 345                 350         


Gly Ser Gly His Met Asn Tyr Ile Gln Val Thr Pro Gln Glu Lys Glu 
        355                 360                 365             


Ala Ile Glu Arg Leu Lys Ala Leu Gly Phe Pro Glu Gly Leu Val Ile 
    370                 375                 380                 


Gln Ala Tyr Phe Ala Cys Glu Lys Asn Glu Asn Leu Ala Ala Asn Phe 
385                 390                 395                 400 


Leu Leu Gln Gln Asn Phe Asp Glu Asp 
                405                 


