                         SEQUENCE LISTING

<110>  Molecular Templates, Inc.
 
<120>  PD-L1 BINDING MOLECULES COMPRISING SHIGA TOXIN A SUBUNIT 
       SCAFFOLDS

<130>  MTEM-031/01WO 333064-2394

<150>  US 63/162,488
<151>  2021-03-17

<160>  316   

<170>  PatentIn version 3.5

<210>  1
<211>  293
<212>  PRT
<213>  Unknown

<220>
<223>  Shiga-like toxin 1 Subunit A (SLT-1A)

<400>  1

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Met Ala Ser Asp Glu 
                245                 250                 255     


Phe Pro Ser Met Cys Pro Ala Asp Gly Arg Val Arg Gly Ile Thr His 
            260                 265                 270         


Asn Lys Ile Leu Trp Asp Ser Ser Thr Leu Gly Ala Ile Leu Met Arg 
        275                 280                 285             


Arg Thr Ile Ser Ser 
    290             


<210>  2
<211>  293
<212>  PRT
<213>  Unknown

<220>
<223>  Shiga toxin Subunit A (StxA)

<400>  2

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Met Ala Ser Asp Glu 
                245                 250                 255     


Phe Pro Ser Met Cys Pro Ala Asp Gly Arg Val Arg Gly Ile Thr His 
            260                 265                 270         


Asn Lys Ile Leu Trp Asp Ser Ser Thr Leu Gly Ala Ile Leu Met Arg 
        275                 280                 285             


Arg Thr Ile Ser Ser 
    290             


<210>  3
<211>  297
<212>  PRT
<213>  Unknown

<220>
<223>  Shiga-like toxin 2 Subunit A (SLT-2A)

<400>  3

Asp Glu Phe Thr Val Asp Phe Ser Ser Gln Lys Ser Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Ser Ile Arg Ser Ala Ile Ser Thr Pro Leu Gly Asn Ile Ser 
            20                  25                  30          


Gln Gly Gly Val Ser Val Ser Val Ile Asn His Val Leu Gly Gly Asn 
        35                  40                  45              


Tyr Ile Ser Leu Asn Val Arg Gly Leu Asp Pro Tyr Ser Glu Arg Phe 
    50                  55                  60                  


Asn His Leu Arg Leu Ile Met Glu Arg Asn Asn Leu Tyr Val Ala Gly 
65                  70                  75                  80  


Phe Ile Asn Thr Glu Thr Asn Ile Phe Tyr Arg Phe Ser Asp Phe Ser 
                85                  90                  95      


His Ile Ser Val Pro Asp Val Ile Thr Val Ser Met Thr Thr Asp Ser 
            100                 105                 110         


Ser Tyr Ser Ser Leu Gln Arg Ile Ala Asp Leu Glu Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Gly Arg His Ser Leu Val Gly Ser Tyr Leu Asp Leu Met Glu 
    130                 135                 140                 


Phe Arg Gly Arg Ser Met Thr Arg Ala Ser Ser Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Ile Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Pro Ala Leu Ser Glu Ala Ser Pro Leu Tyr Thr Met Thr 
            180                 185                 190         


Ala Gln Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Ile Ser Asn Val 
        195                 200                 205             


Leu Pro Glu Tyr Arg Gly Glu Glu Gly Val Arg Ile Gly Arg Ile Ser 
    210                 215                 220                 


Phe Asn Ser Leu Ser Ala Ile Leu Gly Ser Val Ala Val Ile Leu Asn 
225                 230                 235                 240 


Cys His Ser Thr Gly Ser Tyr Ser Val Arg Ser Val Ser Gln Lys Gln 
                245                 250                 255     


Lys Thr Glu Cys Gln Ile Val Gly Asp Arg Ala Ala Ile Lys Val Asn 
            260                 265                 270         


Asn Val Leu Trp Glu Ala Asn Thr Ile Ala Ala Leu Leu Asn Arg Lys 
        275                 280                 285             


Pro Gln Asp Leu Thr Glu Pro Asn Gln 
    290                 295         


<210>  4
<211>  251
<212>  PRT
<213>  Unknown

<220>
<223>  Shiga toxin subtype c Subunit A (Stx1cA)

<400>  4

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Val Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg 
                245                 250     


<210>  5
<211>  251
<212>  PRT
<213>  Unknown

<220>
<223>  Shiga toxin subtype d Subunit A (Stx1dA)

<400>  5

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Lys Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Met Gly Leu Glu Pro Glu Glu Glu Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Arg Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


Tyr Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Ile Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg 
                245                 250     


<210>  6
<211>  251
<212>  PRT
<213>  Unknown

<220>
<223>  Shiga toxin subtype e Subunit A (Stx1eA)

<400>  6

Gln Asp Phe Thr Val Asp Phe Ser Thr Ala Lys Lys Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Ala Ile Arg Ser Ala Ile Gly Thr Pro Leu His Ser Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Gly Thr Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Arg Gly Leu Asp Pro Glu Glu Glu Arg Phe 
    50                  55                  60                  


Asp Asn Leu Arg Leu Ile Ile Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Ser Asn Ile Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Arg Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Gly Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


Tyr Ser Gly Ser Ser Leu Thr Gln Pro Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Val Ser Gly His Ser Tyr Thr Met 
            180                 185                 190         


Thr Val Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Gly Val Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Thr Ser Arg Val Ser Arg 
                245                 250     


<210>  7
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin subtype 2c Subunit A (Stx2cA) variant 1

<400>  7

Arg Glu Phe Thr Ile Asp Phe Ser Thr Gln Gln Ser Tyr Val Ser Ser 
1               5                   10                  15      


Leu Asn Ser Ile Arg Thr Glu Ile Ser Thr Pro Leu Glu His Ile Ser 
            20                  25                  30          


Gln Gly Thr Thr Ser Val Ser Val Ile Asn His Thr Pro Pro Gly Ser 
        35                  40                  45              


Tyr Phe Ala Val Asp Ile Arg Gly Leu Asp Val Tyr Gln Ala Arg Phe 
    50                  55                  60                  


Asp His Leu Arg Leu Ile Ile Glu Gln Asn Asn Leu Tyr Val Ala Gly 
65                  70                  75                  80  


Phe Val Asn Thr Ala Thr Asn Thr Phe Tyr Arg Phe Ser Asp Phe Thr 
                85                  90                  95      


His Ile Ser Val Pro Gly Val Thr Thr Val Ser Met Thr Thr Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Ala Leu Glu Arg Ser Gly Met 
        115                 120                 125             


Gln Ile Ser Arg His Ser Leu Val Ser Ser Tyr Leu Ala Leu Met Glu 
    130                 135                 140                 


Phe Ser Gly Asn Thr Met Thr Arg Asp Ala Ser Arg Ala Val Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Glu Phe Arg Gln Ala Leu Ser Glu Thr Ala Pro Val Tyr Thr Met Thr 
            180                 185                 190         


Pro Gly Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Ile Ser Asn Val 
        195                 200                 205             


Leu Pro Glu Tyr Arg Gly Glu Asp Gly Val Arg Val Gly Arg Ile Ser 
    210                 215                 220                 


Phe Asn Asn Ile Ser Ala Ile Leu Gly Thr Val Ala Val Ile Leu Asn 
225                 230                 235                 240 


Cys His His Gln Gly Ala Arg Ser Val Arg 
                245                 250 


<210>  8
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin subtype 2c Subunit A (Stx2cA) variant 2

<400>  8

Arg Glu Phe Thr Ile Asp Phe Ser Thr Gln Gln Ser Tyr Val Ser Ser 
1               5                   10                  15      


Leu Asn Ser Ile Arg Thr Glu Ile Ser Thr Pro Leu Glu His Ile Ser 
            20                  25                  30          


Gln Gly Thr Thr Ser Val Ser Val Ile Asn His Thr Pro Pro Gly Ser 
        35                  40                  45              


Tyr Phe Ala Val Asp Ile Arg Gly Leu Asp Val Tyr Gln Ala Arg Phe 
    50                  55                  60                  


Asp His Leu Arg Leu Ile Ile Glu Gln Asn Asn Leu Tyr Val Ala Gly 
65                  70                  75                  80  


Phe Val Asn Thr Ala Thr Asn Thr Phe Tyr Arg Phe Ser Asp Phe Ala 
                85                  90                  95      


His Ile Ser Val Pro Gly Val Thr Thr Val Ser Met Thr Thr Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Ala Leu Glu Arg Ser Gly Met 
        115                 120                 125             


Gln Ile Ser Arg His Ser Leu Val Ser Ser Tyr Leu Ala Leu Met Glu 
    130                 135                 140                 


Phe Ser Gly Asn Thr Met Thr Arg Asp Ala Ser Arg Ala Val Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Glu Phe Arg Gln Ala Leu Ser Glu Thr Ala Pro Val Tyr Thr Met Thr 
            180                 185                 190         


Pro Gly Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Ile Ser Asn Val 
        195                 200                 205             


Leu Pro Glu Tyr Arg Gly Glu Asp Gly Val Arg Val Gly Arg Ile Ser 
    210                 215                 220                 


Phe Asn Asn Ile Ser Ala Ile Leu Gly Thr Val Ala Val Ile Leu Asn 
225                 230                 235                 240 


Cys His His Gln Gly Ala Arg Ser Val Arg 
                245                 250 


<210>  9
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin subtype 2c Subunit A (Stx2cA) variant 3

<400>  9

Arg Glu Phe Thr Ile Asp Phe Ser Thr Gln Gln Ser Tyr Val Ser Ser 
1               5                   10                  15      


Leu Asn Ser Ile Arg Thr Glu Ile Ser Thr Pro Leu Glu His Ile Ser 
            20                  25                  30          


Gln Gly Thr Thr Ser Val Ser Val Ile Asn His Thr Pro Pro Gly Ser 
        35                  40                  45              


Tyr Phe Ala Val Asp Ile Arg Gly Leu Asp Ile Tyr Gln Ala Arg Phe 
    50                  55                  60                  


Asp His Leu Arg Leu Ile Ile Glu Gln Asn Asn Leu Tyr Val Ala Gly 
65                  70                  75                  80  


Phe Val Asn Thr Ala Thr Asn Thr Phe Tyr Arg Phe Ser Asp Phe Thr 
                85                  90                  95      


His Ile Ser Val Pro Gly Val Thr Thr Val Ser Met Thr Thr Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Ala Leu Glu Arg Ser Gly Met 
        115                 120                 125             


Gln Ile Ser Arg His Ser Leu Val Ser Ser Tyr Leu Ala Leu Met Glu 
    130                 135                 140                 


Phe Ser Gly Asn Thr Met Thr Arg Asp Ala Ser Arg Ala Val Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Glu Phe Arg Gln Ala Leu Ser Glu Thr Ala Pro Val Tyr Thr Met Thr 
            180                 185                 190         


Pro Gly Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Ile Ser Asn Val 
        195                 200                 205             


Leu Pro Glu Tyr Arg Gly Glu Asp Gly Val Arg Val Gly Arg Ile Ser 
    210                 215                 220                 


Phe Asn Asn Ile Ser Ala Ile Leu Gly Thr Val Ala Val Ile Leu Asn 
225                 230                 235                 240 


Cys His His Gln Gly Ala Arg Ser Val Arg 
                245                 250 


<210>  10
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin subtype 2c Subunit A (Stx2cA) variant 4

<400>  10

Arg Glu Phe Thr Ile Asp Phe Ser Thr Gln Gln Ser Tyr Val Ser Ser 
1               5                   10                  15      


Leu Asn Ser Ile Arg Thr Glu Ile Ser Thr Pro Leu Glu His Ile Ser 
            20                  25                  30          


Gln Gly Thr Thr Ser Val Ser Val Ile Asn His Thr Pro Pro Gly Ser 
        35                  40                  45              


Tyr Phe Ala Val Asp Ile Arg Gly Leu Asp Val Tyr Gln Ala Arg Phe 
    50                  55                  60                  


Asp His Leu Arg Leu Ile Ile Glu Gln Asn Asn Leu Tyr Val Ala Gly 
65                  70                  75                  80  


Phe Val Asn Thr Ala Thr Asn Thr Phe Tyr Arg Phe Ser Asp Phe Thr 
                85                  90                  95      


His Ile Ser Val Pro Ser Val Thr Thr Val Ser Met Thr Thr Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Ala Leu Glu Arg Ser Gly Met 
        115                 120                 125             


Gln Ile Ser Arg His Ser Leu Val Ser Ser Tyr Leu Ala Leu Met Glu 
    130                 135                 140                 


Phe Ser Gly Asn Thr Met Thr Arg Asp Ala Ser Arg Ala Val Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Glu Phe Arg Gln Ala Leu Ser Glu Thr Ala Pro Val Tyr Thr Met Thr 
            180                 185                 190         


Pro Gly Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Ile Ser Asn Val 
        195                 200                 205             


Leu Pro Glu Tyr Arg Gly Glu Asp Gly Val Arg Val Gly Arg Ile Ser 
    210                 215                 220                 


Phe Asn Asn Ile Ser Ala Ile Leu Gly Thr Val Ala Val Ile Leu Asn 
225                 230                 235                 240 


Cys His His Gln Gly Ala Arg Ser Val Arg 
                245                 250 


<210>  11
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin subtype 2c Subunit A (Stx2cA) variant 5

<400>  11

Arg Glu Phe Thr Ile Asp Phe Ser Thr Gln Gln Ser Tyr Val Ser Ser 
1               5                   10                  15      


Leu Asn Ser Ile Arg Thr Glu Ile Ser Thr Pro Leu Glu His Ile Ser 
            20                  25                  30          


Gln Gly Thr Thr Ser Val Ser Val Ile Asn His Thr Pro Pro Gly Ser 
        35                  40                  45              


Tyr Phe Ala Val Asp Ile Arg Gly Leu Asp Val Tyr Gln Ala Arg Phe 
    50                  55                  60                  


Asp His Leu Arg Leu Ile Ile Glu Gln Asn Asn Leu Tyr Met Ala Gly 
65                  70                  75                  80  


Phe Val Asn Thr Ala Thr Asn Thr Phe Tyr Arg Phe Ser Asp Phe Thr 
                85                  90                  95      


His Ile Ser Val Pro Ser Val Thr Thr Val Ser Met Thr Thr Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Ala Leu Glu Arg Ser Gly Met 
        115                 120                 125             


Gln Ile Ser Arg His Ser Leu Val Ser Ser Tyr Leu Ala Leu Met Glu 
    130                 135                 140                 


Phe Ser Gly Asn Thr Met Thr Arg Asp Ala Ser Arg Ala Val Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Glu Phe Arg Gln Ala Leu Ser Glu Thr Ala Pro Val Tyr Thr Met Thr 
            180                 185                 190         


Pro Gly Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Ile Ser Asn Val 
        195                 200                 205             


Leu Pro Glu Tyr Arg Gly Glu Asp Gly Val Arg Val Gly Arg Ile Ser 
    210                 215                 220                 


Phe Asn Asn Ile Ser Ala Ile Leu Gly Thr Val Ala Val Ile Leu Asn 
225                 230                 235                 240 


Cys His His Gln Gly Ala Arg Ser Val Arg 
                245                 250 


<210>  12
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin subtype 2c Subunit A (Stx2cA) variant 6

<400>  12

Arg Glu Phe Thr Ile Asp Phe Ser Thr Gln Gln Ser Tyr Val Ser Ser 
1               5                   10                  15      


Leu Asn Ser Ile Arg Thr Glu Ile Ser Thr Pro Leu Glu His Ile Ser 
            20                  25                  30          


Gln Gly Thr Thr Ser Val Ser Val Ile Asn His Thr Pro Pro Gly Ser 
        35                  40                  45              


Tyr Phe Ala Val Asp Ile Arg Gly Leu Asp Val Tyr Gln Ala Arg Phe 
    50                  55                  60                  


Asp His Leu Arg Leu Ile Ile Glu Gln Asn Asn Leu Tyr Val Ala Gly 
65                  70                  75                  80  


Phe Val Asn Thr Ala Thr Asn Thr Phe Tyr Arg Phe Ser Asp Phe Thr 
                85                  90                  95      


His Ile Ser Val Pro Gly Val Thr Thr Val Ser Met Thr Thr Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Ala Leu Glu Arg Ser Gly Met 
        115                 120                 125             


Gln Ile Ser Arg His Ser Leu Val Ser Ser Tyr Leu Ala Leu Met Glu 
    130                 135                 140                 


Phe Ser Gly Asn Thr Met Thr Arg Asp Ala Ser Arg Ala Val Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Glu Phe Arg Gln Val Leu Ser Glu Thr Ala Pro Val Tyr Thr Met Thr 
            180                 185                 190         


Pro Gly Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Ile Ser Asn Val 
        195                 200                 205             


Leu Pro Glu Tyr Arg Gly Glu Asp Gly Val Arg Val Gly Arg Ile Ser 
    210                 215                 220                 


Phe Asn Asn Ile Ser Ala Ile Leu Ser Thr Val Ala Val Ile Leu Asn 
225                 230                 235                 240 


Cys His His Gln Gly Ala Arg Ser Val Arg 
                245                 250 


<210>  13
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin subtype 2d Subunit A (Stx2dA) variant 1

<400>  13

Arg Glu Phe Thr Ile Asp Phe Ser Thr Gln Gln Ser Tyr Val Ser Ser 
1               5                   10                  15      


Leu Asn Ser Ile Arg Thr Glu Ile Ser Thr Pro Leu Glu His Ile Ser 
            20                  25                  30          


Gln Gly Thr Thr Ser Val Ser Val Ile Asn His Thr Pro Pro Gly Ser 
        35                  40                  45              


Tyr Phe Ala Val Asp Ile Arg Gly Leu Asp Val Tyr Gln Ala Arg Phe 
    50                  55                  60                  


Asp His Leu Arg Leu Ile Ile Glu Gln Asn Asn Leu Tyr Val Ala Gly 
65                  70                  75                  80  


Phe Val Asn Thr Ala Thr Asn Thr Phe Tyr Arg Phe Ser Asp Phe Ala 
                85                  90                  95      


His Ile Ser Val Pro Gly Val Thr Thr Val Ser Met Thr Thr Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Ala Leu Glu Arg Ser Gly Met 
        115                 120                 125             


Gln Ile Ser Arg His Ser Leu Val Ser Ser Tyr Leu Ala Leu Met Glu 
    130                 135                 140                 


Phe Ser Gly Asn Thr Met Thr Arg Asp Ala Ser Arg Ala Val Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Glu Phe Arg Gln Ala Leu Ser Glu Thr Ala Pro Val Tyr Thr Met Thr 
            180                 185                 190         


Pro Gly Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Ile Ser Asn Val 
        195                 200                 205             


Ile Pro Glu Tyr Arg Gly Glu Asp Gly Val Arg Val Gly Arg Ile Ser 
    210                 215                 220                 


Phe Asn Asn Ile Ser Ala Ile Leu Gly Thr Val Ala Val Ile Leu Asn 
225                 230                 235                 240 


Cys His His Gln Gly Ala Arg Ser Val Arg 
                245                 250 


<210>  14
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin subtype 2d Subunit A (Stx2dA) variant 2

<400>  14

Arg Glu Phe Met Ile Asp Phe Ser Thr Gln Gln Ser Tyr Val Ser Ser 
1               5                   10                  15      


Leu Asn Ser Ile Arg Thr Glu Ile Ser Thr Pro Leu Glu His Ile Ser 
            20                  25                  30          


Gln Gly Thr Thr Ser Val Ser Val Ile Asn His Thr Pro Pro Gly Ser 
        35                  40                  45              


Tyr Phe Ala Val Asp Ile Arg Gly Leu Asp Val Tyr Gln Ala Arg Phe 
    50                  55                  60                  


Asp His Leu Arg Leu Ile Ile Glu Gln Asn Asn Leu Tyr Val Ala Gly 
65                  70                  75                  80  


Phe Val Asn Thr Ala Thr Asn Thr Phe Tyr Arg Phe Ser Asp Phe Thr 
                85                  90                  95      


His Ile Ser Val Pro Gly Val Thr Thr Val Ser Met Thr Thr Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Ala Leu Glu Arg Ser Gly Met 
        115                 120                 125             


Gln Ile Ser Arg His Ser Leu Val Ser Ser Tyr Leu Ala Leu Met Glu 
    130                 135                 140                 


Phe Ser Gly Asn Thr Met Thr Arg Asp Ala Ser Arg Ala Val Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Glu Phe Arg Gln Ala Leu Ser Glu Thr Ala Pro Val Tyr Thr Met Thr 
            180                 185                 190         


Pro Glu Glu Val Asp Leu Thr Leu Asn Trp Gly Arg Ile Ser Asn Val 
        195                 200                 205             


Leu Pro Glu Phe Arg Gly Glu Gly Gly Val Arg Val Gly Arg Ile Ser 
    210                 215                 220                 


Phe Asn Asn Ile Ser Ala Ile Leu Gly Thr Val Ala Val Ile Leu Asn 
225                 230                 235                 240 


Cys His His Gln Gly Ala Arg Ser Val Arg 
                245                 250 


<210>  15
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin subtype 2d Subunit A (Stx2dA) variant 3

<400>  15

Arg Glu Phe Thr Ile Asp Phe Ser Thr Gln Gln Ser Tyr Val Ser Ser 
1               5                   10                  15      


Leu Asn Ser Ile Arg Thr Glu Ile Ser Thr Pro Leu Glu His Ile Ser 
            20                  25                  30          


Gln Gly Thr Thr Ser Val Ser Val Ile Asn His Thr Pro Pro Gly Ser 
        35                  40                  45              


Tyr Phe Ala Val Asp Ile Arg Gly Leu Asp Val Tyr Gln Ala Arg Phe 
    50                  55                  60                  


Asp His Leu Arg Leu Ile Ile Glu Gln Asn Asn Leu Tyr Val Ala Gly 
65                  70                  75                  80  


Phe Val Asn Thr Ala Thr Asn Thr Phe Tyr Arg Phe Ser Asp Phe Thr 
                85                  90                  95      


His Ile Ser Val Pro Gly Val Thr Thr Val Ser Met Thr Thr Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Ala Leu Glu Arg Ser Gly Met 
        115                 120                 125             


Gln Ile Ser Arg His Ser Leu Val Ser Ser Tyr Leu Ala Leu Met Glu 
    130                 135                 140                 


Phe Ser Gly Asn Thr Met Thr Arg Asp Ala Ser Arg Ala Val Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Glu Phe Arg Gln Ala Leu Ser Glu Thr Ala Pro Val Tyr Thr Met Thr 
            180                 185                 190         


Pro Gly Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Ile Ser Asn Val 
        195                 200                 205             


Ile Pro Glu Tyr Arg Gly Glu Asp Gly Val Arg Val Gly Arg Ile Ser 
    210                 215                 220                 


Phe Asn Asn Ile Ser Ala Ile Leu Ser Thr Val Ala Val Ile Leu Asn 
225                 230                 235                 240 


Cys His His Gln Gly Ala Arg Ser Val Arg 
                245                 250 


<210>  16
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin subtype 2e Subunit A (Stx2eA) variant 1

<400>  16

Gln Glu Phe Thr Ile Asp Phe Ser Thr Gln Gln Ser Tyr Val Ser Ser 
1               5                   10                  15      


Leu Asn Ser Ile Arg Thr Ala Ile Ser Thr Pro Leu Glu His Ile Ser 
            20                  25                  30          


Gln Gly Ala Thr Ser Val Ser Val Ile Asn His Thr Pro Pro Gly Ser 
        35                  40                  45              


Tyr Ile Ser Val Gly Ile Arg Gly Leu Asp Val Tyr Gln Glu Arg Phe 
    50                  55                  60                  


Asp His Leu Arg Leu Ile Ile Glu Arg Asn Asn Leu Tyr Val Ala Gly 
65                  70                  75                  80  


Phe Val Asn Thr Thr Thr Asn Thr Phe Tyr Arg Phe Ser Asp Phe Ala 
                85                  90                  95      


His Ile Ser Leu Pro Gly Val Thr Thr Ile Ser Met Thr Thr Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Ala Leu Glu Arg Ser Gly Met 
        115                 120                 125             


Gln Ile Ser Arg His Ser Leu Val Ser Ser Tyr Leu Ala Leu Met Glu 
    130                 135                 140                 


Phe Ser Gly Asn Thr Met Thr Arg Asp Ala Ser Arg Ala Val Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Glu Phe Arg Leu Ala Leu Ser Glu Thr Ala Pro Val Tyr Thr Met Thr 
            180                 185                 190         


Pro Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Ile Ser Asn Val 
        195                 200                 205             


Leu Pro Glu Tyr Arg Gly Glu Ala Gly Val Arg Val Gly Arg Ile Ser 
    210                 215                 220                 


Phe Asn Asn Ile Ser Ala Ile Leu Gly Thr Val Ala Val Ile Leu Asn 
225                 230                 235                 240 


Cys His His Gln Gly Ala Arg Ser Val Arg 
                245                 250 


<210>  17
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin subtype 2e Subunit A (Stx2eA) variant 2

<400>  17

Gln Glu Phe Thr Ile Asp Phe Ser Thr Gln Gln Ser Tyr Val Ser Ser 
1               5                   10                  15      


Leu Asn Ser Ile Arg Thr Ala Ile Ser Thr Pro Leu Glu His Ile Ser 
            20                  25                  30          


Gln Gly Ala Thr Ser Val Ser Val Ile Asn His Thr Pro Pro Gly Ser 
        35                  40                  45              


Tyr Ile Ser Val Gly Ile Arg Gly Leu Asp Val Tyr Gln Ala His Phe 
    50                  55                  60                  


Asp His Leu Arg Leu Ile Ile Glu Gln Asn Asn Leu Tyr Val Ala Gly 
65                  70                  75                  80  


Phe Val Asn Thr Ala Thr Asn Thr Phe Tyr Arg Phe Ser Asp Phe Ala 
                85                  90                  95      


His Ile Ser Leu Pro Gly Val Thr Thr Ile Ser Met Thr Thr Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Ala Leu Glu Arg Ser Gly Met 
        115                 120                 125             


Gln Ile Ser Arg His Ser Leu Val Ser Ser Tyr Leu Ala Leu Met Glu 
    130                 135                 140                 


Phe Ser Gly Asn Thr Met Thr Arg Glu Ala Ser Arg Ala Val Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Glu Phe Arg Gln Ala Leu Ser Glu Thr Ala Pro Val Tyr Thr Met Thr 
            180                 185                 190         


Pro Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Ile Ser Asn Val 
        195                 200                 205             


Leu Pro Glu Tyr Arg Gly Glu Asp Gly Val Arg Val Gly Arg Ile Ser 
    210                 215                 220                 


Phe Asn Asn Ile Ser Ala Ile Leu Gly Thr Val Ala Val Ile Leu Asn 
225                 230                 235                 240 


Cys His His Gln Gly Ala Arg Ser Val Arg 
                245                 250 


<210>  18
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin subtype 2f Subunit A (Stx2fA)

<400>  18

Asp Glu Phe Thr Val Asp Phe Ser Ser Gln Lys Ser Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Ser Ile Arg Ser Ala Ile Ser Thr Pro Leu Gly Asn Ile Ser 
            20                  25                  30          


Gln Gly Gly Val Ser Val Ser Val Ile Asn His Val Pro Gly Gly Asn 
        35                  40                  45              


Tyr Ile Ser Leu Asn Val Arg Gly Leu Asp Pro Tyr Ser Glu Arg Phe 
    50                  55                  60                  


Asn His Leu Arg Leu Ile Met Glu Arg Asn Asn Leu Tyr Val Ala Gly 
65                  70                  75                  80  


Phe Ile Asn Thr Glu Thr Asn Thr Phe Tyr Arg Phe Ser Asp Phe Ser 
                85                  90                  95      


His Ile Ser Val Pro Asp Val Ile Thr Val Ser Met Thr Thr Asp Ser 
            100                 105                 110         


Ser Tyr Ser Ser Leu Gln Arg Ile Ala Asp Leu Glu Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Gly Arg His Ser Leu Val Gly Ser Tyr Leu Asp Leu Met Glu 
    130                 135                 140                 


Phe Arg Gly Arg Ser Met Thr Arg Ala Ser Ser Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Ile Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Pro Ala Leu Ser Glu Ala Ser Pro Leu Tyr Thr Met Thr 
            180                 185                 190         


Ala Gln Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Ile Ser Asn Val 
        195                 200                 205             


Leu Pro Glu Tyr Arg Gly Glu Glu Gly Val Arg Ile Gly Arg Ile Ser 
    210                 215                 220                 


Phe Asn Ser Leu Ser Ala Ile Leu Gly Ser Val Ala Val Ile Leu Asn 
225                 230                 235                 240 


Cys His Ser Thr Gly Ser Tyr Ser Val Arg 
                245                 250 


<210>  19
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  light chain HVR CDR1

<400>  19

Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  20
<211>  7
<212>  PRT
<213>  Unknown

<220>
<223>  light chain HVR CDR2

<400>  20

Leu Thr Ser Asn Leu Ala Ser 
1               5           


<210>  21
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  light chain HVR CDR3

<400>  21

Gln Gln Trp Ser Ser Tyr Pro Pro Thr 
1               5                   


<210>  22
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  heavy chain HVR CDR1

<400>  22

Glu Asn Ser Met His 
1               5   


<210>  23
<211>  17
<212>  PRT
<213>  Unknown

<220>
<223>  heavy chain HVR CDR2

<400>  23

Gly Ile Asn Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  24
<211>  13
<212>  PRT
<213>  Unknown

<220>
<223>  heavy chain HVR CDR3

<400>  24

Pro Tyr Tyr Tyr Gly Tyr Arg Glu Asp Tyr Phe Asp Tyr 
1               5                   10              


<210>  25
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  light chain HVR CDR1

<400>  25

Arg Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  26
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  light chain HVR CDR3

<400>  26

Gln Gln Trp Ser Ser Asn Pro Pro Thr 
1               5                   


<210>  27
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  heavy chain HVR CDR1

<400>  27

Glu Tyr Thr Met His 
1               5   


<210>  28
<211>  17
<212>  PRT
<213>  Unknown

<220>
<223>  heavy chain HVR CDR2

<400>  28

Gly Ile Asp Pro Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  29
<211>  17
<212>  PRT
<213>  Unknown

<220>
<223>  heavy chain HVR CDR2

<400>  29

Gly Ile Asn Pro Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  30
<211>  17
<212>  PRT
<213>  Unknown

<220>
<223>  heavy chain HVR CDR2

<400>  30

Gly Ile Asn Pro Asn Asn Gly Gly Thr Trp Tyr Asn Arg Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  31
<211>  17
<212>  PRT
<213>  Unknown

<220>
<223>  heavy chain HVR CDR2

<400>  31

Gly Ile Asn Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  32
<211>  13
<212>  PRT
<213>  Unknown

<220>
<223>  heavy chain HVR CDR3

<400>  32

Pro Tyr Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr 
1               5                   10              


<210>  33
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain 1

<400>  33

Asp Ile Val Met Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  34
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain 1

<400>  34

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Tyr Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  35
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain 2

<400>  35

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  36
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain 3

<400>  36

Asp Ile Val Leu Asn Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  37
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain 2

<400>  37

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr Trp Tyr Asn Arg Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ala Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Tyr Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  38
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain 4

<400>  38

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  39
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain 3

<400>  39

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr Trp Tyr Asn Arg Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ala Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Tyr Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  40
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin effector polypeptide 1

<400>  40

Ala Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  41
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin effector polypeptide 2

<400>  41

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  42
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin effector polypeptide 3

<400>  42

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  43
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin effector polypeptide 4

<400>  43

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  44
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin effector polypeptide 5

<400>  44

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  45
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin effector polypeptide 6

<400>  45

Ala Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Asp Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  46
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin effector polypeptide 7

<400>  46

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Asp Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  47
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin effector polypeptide 8

<400>  47

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Asp Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  48
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin effector polypeptide 9

<400>  48

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Asp Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  49
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin effector polypeptide 10

<400>  49

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Asp Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  50
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin effector polypeptide 11

<400>  50

Lys Glu Phe Ile Leu Arg Phe Ser Val Ala His Lys Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  51
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin effector polypeptide 12

<400>  51

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met Val 
        35                  40                  45              


Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  52
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin effector polypeptide 13

<400>  52

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Asn Leu Val Pro Met 
        35                  40                  45              


Val Ala Thr Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  53
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin effector polypeptide 14

<400>  53

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Leu Gly Phe 
        35                  40                  45              


Val Phe Thr Leu Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  54
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin effector polypeptide 15

<400>  54

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  55
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin effector polypeptide 16

<400>  55

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Val Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  56
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin effector polypeptide 17

<400>  56

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  57
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin effector polypeptide 18

<400>  57

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Phe Val Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  58
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin effector polypeptide 19

<400>  58

Lys Glu Phe Ile Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro Ile Glu Ala Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Ala Ala Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  59
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin effector polypeptide 20

<400>  59

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Phe Val Phe Thr Leu Glu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250         


<210>  60
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin effector polypeptide 21

<400>  60

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asn Leu Val Pro Met Val Ala Thr Val Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  61
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin effector polypeptide 22

<400>  61

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Asn Leu Val Pro Met Val Ala Thr Val 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  62
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin effector polypeptide 23

<400>  62

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Gly Ile Leu Gly Asp Val Phe Thr Leu Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  63
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin effector polypeptide 24

<400>  63

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ile Leu Arg Phe Ser Val Ala His Lys Ala Ser 
                245                 250                 255     


Ala Val Ala Ala 
            260 


<210>  64
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin effector polypeptide 25

<400>  64

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Arg Asn Leu Val Pro Met Val Ala Thr Val 
                245                 250                 255     


Ala Ser Ala Val Ala Ala 
            260         


<210>  65
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin effector polypeptide 26

<400>  65

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Asn Leu Val Pro Met Val Ala Thr Val 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  66
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin effector polypeptide 27

<400>  66

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Gly Ile Leu Gly Asp Val Phe Thr Leu Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  67
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin effector polypeptide 28

<400>  67

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ile Leu Arg Phe Ser Val Ala His Lys Ala Ser 
                245                 250                 255     


Ala Val Ala Ala 
            260 


<210>  68
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin effector polypeptide 29

<400>  68

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Arg Asn Leu Val Pro Met Val Ala Thr Val 
                245                 250                 255     


Ala Ser Ala Val Ala Ala 
            260         


<210>  69
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker 1

<400>  69

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  70
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker 2

<400>  70

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  71
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker 3

<400>  71

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  72
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker 4

<400>  72

Gly Gly Gly Gly Ser 
1               5   


<210>  73
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker 5

<400>  73

Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro 
1               5                   10                  15      


<210>  74
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker 6

<400>  74

Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro 
1               5                   10                  15      


Gly Ile Leu Gly Phe Val Phe Thr Leu 
            20                  25  


<210>  75
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker 7

<400>  75

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
1               5                   10                  15  


<210>  76
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker 8

<400>  76

Ser Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Ala Ser 
1               5                   10                  15      


<210>  77
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker 9

<400>  77

Ala His His Ser Glu Asp Pro Ser Ser Lys Ala Pro Lys Ala Pro 
1               5                   10                  15  


<210>  78
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  T-cell epitope-peptide C1

<400>  78

Asn Leu Val Pro Met Val Ala Thr Val 
1               5                   


<210>  79
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  T-cell epitope-peptide C2

<400>  79

Val Thr Glu His Asp Thr Leu Leu Tyr 
1               5                   


<210>  80
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  T-cell epitope-peptide C4

<400>  80

Ser Ile Ile Asn Phe Glu Lys Tyr Leu 
1               5                   


<210>  81
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  T-cell epitope-peptide C1-2

<400>  81

Gly Leu Asp Arg Asn Ser Gly Asn Tyr 
1               5                   


<210>  82
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  T-cell epitope-peptide C1-3

<400>  82

Gly Val Met Thr Arg Gly Arg Leu Lys 
1               5                   


<210>  83
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  T-cell epitope-peptide F2

<400>  83

Gly Ile Leu Gly Phe Val Phe Thr Leu 
1               5                   


<210>  84
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  T-cell epitope-peptide F3

<400>  84

Ile Leu Arg Gly Ser Val Ala His Lys 
1               5                   


<210>  85
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-chain variable fragment I

<400>  85

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Glu 
            100                 105                 110         


Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
        115                 120                 125             


Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Asn Ser 
    130                 135                 140                 


Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
145                 150                 155                 160 


Gly Ile Asn Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys 
                165                 170                 175     


Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
            180                 185                 190         


Glu Phe Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
        195                 200                 205             


Arg Pro Tyr Tyr Tyr Gly Tyr Arg Glu Asp Tyr Phe Asp Tyr Trp Gly 
    210                 215                 220                 


Gln Gly Thr Thr Leu Thr Val Ser Ser 
225                 230             


<210>  86
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-chain variable fragment II

<400>  86

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Glu 
            100                 105                 110         


Val His Leu Val Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
        115                 120                 125             


Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr 
    130                 135                 140                 


Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
145                 150                 155                 160 


Gly Ile Asp Pro Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys 
                165                 170                 175     


Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
            180                 185                 190         


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala 
        195                 200                 205             


Arg Pro Tyr Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly 
    210                 215                 220                 


Gln Gly Thr Thr Leu Thr Val Ser Ser 
225                 230             


<210>  87
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-chain variable fragment III

<400>  87

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Glu 
            100                 105                 110         


Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
        115                 120                 125             


Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr 
    130                 135                 140                 


Met His Trp Val Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile Gly 
145                 150                 155                 160 


Gly Ile Asn Pro Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys 
                165                 170                 175     


Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
            180                 185                 190         


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala 
        195                 200                 205             


Arg Pro Tyr Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly 
    210                 215                 220                 


Gln Gly Thr Thr Leu Thr Val Ser Ser 
225                 230             


<210>  88
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-chain variable fragment IV

<400>  88

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Glu 
            100                 105                 110         


Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
        115                 120                 125             


Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr 
    130                 135                 140                 


Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
145                 150                 155                 160 


Gly Ile Asn Pro Asn Asn Gly Gly Thr Trp Tyr Asn Arg Lys Phe Lys 
                165                 170                 175     


Gly Lys Ala Ala Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
            180                 185                 190         


Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala 
        195                 200                 205             


Arg Pro Tyr Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly 
    210                 215                 220                 


Gln Gly Thr Thr Leu Thr Val Ser Ser 
225                 230             


<210>  89
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-chain variable fragment V

<400>  89

Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Asn 
            20                  25                  30          


Ser Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Phe Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Tyr Tyr Tyr Gly Tyr Arg Glu Asp Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val 
                165                 170                 175     


Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro 
            180                 185                 190         


Trp Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met 
    210                 215                 220                 


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr 
225                 230                 235                 240 


Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
                245                 250             


<210>  90
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-chain variable fragment VI

<400>  90

Glu Val His Leu Val Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asp Pro Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Tyr Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val 
                165                 170                 175     


Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro 
            180                 185                 190         


Trp Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met 
    210                 215                 220                 


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn 
225                 230                 235                 240 


Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
                245                 250             


<210>  91
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-chain variable fragment VII

<400>  91

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Tyr Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val 
                165                 170                 175     


Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro 
            180                 185                 190         


Trp Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met 
    210                 215                 220                 


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn 
225                 230                 235                 240 


Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
                245                 250             


<210>  92
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-chain variable fragment VIII

<400>  92

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr Trp Tyr Asn Arg Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ala Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Tyr Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val 
                165                 170                 175     


Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro 
            180                 185                 190         


Trp Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met 
    210                 215                 220                 


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn 
225                 230                 235                 240 


Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
                245                 250             


<210>  93
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-chain variable fragment IX

<400>  93

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln 
            100                 105                 110         


Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala Ser 
        115                 120                 125             


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Asn Ser 
    130                 135                 140                 


Met His Trp Val Arg Gln Ser His Gly Lys Ser Leu Glu Trp Met Gly 
145                 150                 155                 160 


Gly Ile Asn Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys 
                165                 170                 175     


Gly Lys Val Thr Met Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr Met 
            180                 185                 190         


Glu Leu Arg Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
        195                 200                 205             


Arg Pro Tyr Tyr Tyr Gly Tyr Arg Glu Asp Tyr Phe Asp Tyr Trp Gly 
    210                 215                 220                 


Gln Gly Thr Thr Leu Thr Val Ser Ser 
225                 230             


<210>  94
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-chain variable fragment X

<400>  94

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln 
            100                 105                 110         


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
        115                 120                 125             


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Asn Ser 
    130                 135                 140                 


Met His Trp Val Arg Gln Ala His Gly Gln Arg Leu Glu Trp Ile Gly 
145                 150                 155                 160 


Gly Ile Asn Pro Asn Asn Gly Gly Thr Trp Tyr Asn Arg Lys Phe Lys 
                165                 170                 175     


Gly Lys Ala Ala Ile Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr Met 
            180                 185                 190         


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
        195                 200                 205             


Arg Pro Tyr Tyr Tyr Gly Tyr Arg Glu Asp Tyr Phe Asp Tyr Trp Gly 
    210                 215                 220                 


Gln Gly Thr Thr Leu Thr Val Ser Ser 
225                 230             


<210>  95
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-chain variable fragment XI

<400>  95

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln 
            100                 105                 110         


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
        115                 120                 125             


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Asn Ser 
    130                 135                 140                 


Met His Trp Val Arg Gln Ala His Gly Gln Arg Leu Glu Trp Ile Gly 
145                 150                 155                 160 


Gly Ile Asn Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys 
                165                 170                 175     


Gly Lys Ala Thr Ile Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr Met 
            180                 185                 190         


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
        195                 200                 205             


Arg Pro Tyr Tyr Tyr Gly Tyr Arg Glu Asp Tyr Phe Asp Tyr Trp Gly 
    210                 215                 220                 


Gln Gly Thr Thr Leu Thr Val Ser Ser 
225                 230             


<210>  96
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-chain variable fragment XII

<400>  96

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln 
            100                 105                 110         


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
        115                 120                 125             


Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Asn Ser 
    130                 135                 140                 


Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met Gly 
145                 150                 155                 160 


Gly Ile Asn Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe Gln 
                165                 170                 175     


Gly Arg Val Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
            180                 185                 190         


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
        195                 200                 205             


Arg Pro Tyr Tyr Tyr Gly Tyr Arg Glu Asp Tyr Phe Asp Tyr Trp Gly 
    210                 215                 220                 


Gln Gly Thr Thr Leu Thr Val Ser Ser 
225                 230             


<210>  97
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-chain variable fragment XIII

<400>  97

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Asn 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ser His Gly Lys Ser Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Val Thr Met Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Tyr Tyr Tyr Gly Tyr Arg Glu Asp Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val 
                165                 170                 175     


Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro 
            180                 185                 190         


Leu Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Arg Leu 
    210                 215                 220                 


Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr 
225                 230                 235                 240 


Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
                245                 250             


<210>  98
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-chain variable fragment XIV

<400>  98

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Asn 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala His Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr Trp Tyr Asn Arg Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ala Ile Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Tyr Tyr Tyr Gly Tyr Arg Glu Asp Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val 
                165                 170                 175     


Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro 
            180                 185                 190         


Leu Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Arg Leu 
    210                 215                 220                 


Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr 
225                 230                 235                 240 


Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
                245                 250             


<210>  99
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-chain variable fragment XV

<400>  99

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Asn 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala His Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Ile Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Tyr Tyr Tyr Gly Tyr Arg Glu Asp Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val 
                165                 170                 175     


Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro 
            180                 185                 190         


Leu Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Arg Leu 
    210                 215                 220                 


Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr 
225                 230                 235                 240 


Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
                245                 250             


<210>  100
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-chain variable fragment XVI

<400>  100

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Asn 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Tyr Tyr Tyr Gly Tyr Arg Glu Asp Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val 
                165                 170                 175     


Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro 
            180                 185                 190         


Leu Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Arg Leu 
    210                 215                 220                 


Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr 
225                 230                 235                 240 


Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
                245                 250             


<210>  101
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-chain variable fragment XVII

<400>  101

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Ser Arg His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Tyr Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val 
                165                 170                 175     


Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro 
            180                 185                 190         


Trp Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met 
    210                 215                 220                 


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn 
225                 230                 235                 240 


Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
                245                 250             


<210>  102
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-chain variable fragment XVIII

<400>  102

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr Trp Tyr Asn Arg Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Tyr Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val 
                165                 170                 175     


Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro 
            180                 185                 190         


Trp Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met 
    210                 215                 220                 


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn 
225                 230                 235                 240 


Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
                245                 250             


<210>  103
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-chain variable fragment XIX

<400>  103

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Tyr Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val 
                165                 170                 175     


Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro 
            180                 185                 190         


Trp Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met 
    210                 215                 220                 


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn 
225                 230                 235                 240 


Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
                245                 250             


<210>  104
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-chain variable fragment XX

<400>  104

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Tyr Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val 
                165                 170                 175     


Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro 
            180                 185                 190         


Trp Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met 
    210                 215                 220                 


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn 
225                 230                 235                 240 


Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
                245                 250             


<210>  105
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-chain variable fragment XXI

<400>  105

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Tyr Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Asp 
        115                 120                 125             


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
    130                 135                 140                 


Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
145                 150                 155                 160 


Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu 
                165                 170                 175     


Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
            180                 185                 190         


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp 
        195                 200                 205             


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe 
    210                 215                 220                 


Gly Gly Gly Thr Lys Leu Glu Ile Lys 
225                 230             


<210>  106
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-chain variable fragment XXII

<400>  106

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Tyr Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Asp 
        115                 120                 125             


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
    130                 135                 140                 


Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
145                 150                 155                 160 


Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu 
                165                 170                 175     


Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
            180                 185                 190         


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp 
        195                 200                 205             


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe 
    210                 215                 220                 


Gly Gly Gly Thr Lys Leu Glu Leu Lys 
225                 230             


<210>  107
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-chain variable fragment XXIII

<400>  107

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Tyr Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
    130                 135                 140                 


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser 
145                 150                 155                 160 


Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys 
                165                 170                 175     


Pro Trp Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
            180                 185                 190         


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser 
        195                 200                 205             


Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser 
    210                 215                 220                 


Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
225                 230                 235             


<210>  108
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein 115744

<400>  108

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Cys Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu Thr Ser Asn 
305                 310                 315                 320 


Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe Gly Gly Gly 
        355                 360                 365             


Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Glu Val His Leu Val 
    370                 375                 380                 


Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser 
385                 390                 395                 400 


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp Val 
                405                 410                 415     


Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asp Pro 
            420                 425                 430         


Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
        435                 440                 445             


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser 
    450                 455                 460                 


Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr Tyr 
465                 470                 475                 480 


Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
                485                 490                 495     


Leu Thr Val Ser Ser Asn Leu Val Pro Met Val Ala Thr Val 
            500                 505                 510 


<210>  109
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein 115745

<400>  109

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Cys Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu Thr Ser Asn 
305                 310                 315                 320 


Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe Gly Gly Gly 
        355                 360                 365             


Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Gln 
    370                 375                 380                 


Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser 
385                 390                 395                 400 


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp Val 
                405                 410                 415     


Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn Pro 
            420                 425                 430         


Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
        435                 440                 445             


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser 
    450                 455                 460                 


Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr Tyr 
465                 470                 475                 480 


Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
                485                 490                 495     


Leu Thr Val Ser Ser Asn Leu Val Pro Met Val Ala Thr Val 
            500                 505                 510 


<210>  110
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein 115746

<400>  110

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Cys Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu Thr Ser Asn 
305                 310                 315                 320 


Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe Gly Gly Gly 
        355                 360                 365             


Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Gln 
    370                 375                 380                 


Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser 
385                 390                 395                 400 


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp Val 
                405                 410                 415     


Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn Pro 
            420                 425                 430         


Asn Asn Gly Gly Thr Trp Tyr Asn Arg Lys Phe Lys Gly Lys Ala Ala 
        435                 440                 445             


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser 
    450                 455                 460                 


Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr Tyr 
465                 470                 475                 480 


Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
                485                 490                 495     


Leu Thr Val Ser Ser Asn Leu Val Pro Met Val Ala Thr Val 
            500                 505                 510 


<210>  111
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein 115747

<400>  111

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu 
            260                 265                 270         


Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile 
        275                 280                 285             


Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Asn Ser Met His Trp 
    290                 295                 300                 


Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn 
305                 310                 315                 320 


Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala 
                325                 330                 335     


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Phe Arg 
            340                 345                 350         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Pro Tyr 
        355                 360                 365             


Tyr Tyr Gly Tyr Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
    370                 375                 380                 


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
                405                 410                 415     


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
            420                 425                 430         


Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
        435                 440                 445             


Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu 
    450                 455                 460                 


Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp 
                485                 490                 495     


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Pro Thr Phe 
            500                 505                 510         


Gly Gly Gly Thr Lys Leu Glu Ile Lys His His Ala Ala Asn Leu Val 
        515                 520                 525             


Pro Met Val Ala Thr Val 
    530                 


<210>  112
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein 115748

<400>  112

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val His Leu 
            260                 265                 270         


Val Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile 
        275                 280                 285             


Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp 
    290                 295                 300                 


Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asp 
305                 310                 315                 320 


Pro Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala 
                325                 330                 335     


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg 
            340                 345                 350         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr 
        355                 360                 365             


Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
    370                 375                 380                 


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
                405                 410                 415     


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
            420                 425                 430         


Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
        435                 440                 445             


Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu 
    450                 455                 460                 


Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp 
                485                 490                 495     


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe 
            500                 505                 510         


Gly Gly Gly Thr Lys Leu Glu Ile Lys His His Ala Ala Asn Leu Val 
        515                 520                 525             


Pro Met Val Ala Thr Val 
    530                 


<210>  113
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein 115749

<400>  113

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu 
            260                 265                 270         


Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile 
        275                 280                 285             


Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp 
    290                 295                 300                 


Val Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn 
305                 310                 315                 320 


Pro Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala 
                325                 330                 335     


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg 
            340                 345                 350         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr 
        355                 360                 365             


Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
    370                 375                 380                 


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
                405                 410                 415     


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
            420                 425                 430         


Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
        435                 440                 445             


Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu 
    450                 455                 460                 


Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp 
                485                 490                 495     


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe 
            500                 505                 510         


Gly Gly Gly Thr Lys Leu Glu Leu Lys His His Ala Ala Asn Leu Val 
        515                 520                 525             


Pro Met Val Ala Thr Val 
    530                 


<210>  114
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein 115750

<400>  114

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu 
            260                 265                 270         


Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile 
        275                 280                 285             


Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp 
    290                 295                 300                 


Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn 
305                 310                 315                 320 


Pro Asn Asn Gly Gly Thr Trp Tyr Asn Arg Lys Phe Lys Gly Lys Ala 
                325                 330                 335     


Ala Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg 
            340                 345                 350         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr 
        355                 360                 365             


Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
    370                 375                 380                 


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
                405                 410                 415     


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
            420                 425                 430         


Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
        435                 440                 445             


Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu 
    450                 455                 460                 


Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp 
                485                 490                 495     


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe 
            500                 505                 510         


Gly Gly Gly Thr Lys Leu Glu Ile Lys His His Ala Ala Asn Leu Val 
        515                 520                 525             


Pro Met Val Ala Thr Val 
    530                 


<210>  115
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein 115751

<400>  115

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Ser Pro Ser Thr 
                245                 250                 255     


Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Ala Ser Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile Tyr Leu Thr Ser Asn 
305                 310                 315                 320 


Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Tyr Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Pro Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
    370                 375                 380                 


Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
385                 390                 395                 400 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Asn Ser Met His Trp Val 
                405                 410                 415     


Arg Gln Ser His Gly Lys Ser Leu Glu Trp Met Gly Gly Ile Asn Pro 
            420                 425                 430         


Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Val Thr 
        435                 440                 445             


Met Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser 
    450                 455                 460                 


Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Tyr Tyr 
465                 470                 475                 480 


Tyr Gly Tyr Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
                485                 490                 495     


Leu Thr Val Ser Ser Asn Leu Val Pro Met Val Ala Thr Val 
            500                 505                 510 


<210>  116
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein 115752

<400>  116

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Ser Pro Ser Thr 
                245                 250                 255     


Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Ala Ser Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile Tyr Leu Thr Ser Asn 
305                 310                 315                 320 


Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Tyr Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Pro Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
    370                 375                 380                 


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
385                 390                 395                 400 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Asn Ser Met His Trp Val 
                405                 410                 415     


Arg Gln Ala His Gly Gln Arg Leu Glu Trp Ile Gly Gly Ile Asn Pro 
            420                 425                 430         


Asn Asn Gly Gly Thr Trp Tyr Asn Arg Lys Phe Lys Gly Lys Ala Ala 
        435                 440                 445             


Ile Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser 
    450                 455                 460                 


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Tyr Tyr 
465                 470                 475                 480 


Tyr Gly Tyr Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
                485                 490                 495     


Leu Thr Val Ser Ser Asn Leu Val Pro Met Val Ala Thr Val 
            500                 505                 510 


<210>  117
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein 115753

<400>  117

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Ser Pro Ser Thr 
                245                 250                 255     


Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Ala Ser Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile Tyr Leu Thr Ser Asn 
305                 310                 315                 320 


Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Tyr Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Pro Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
    370                 375                 380                 


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
385                 390                 395                 400 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Asn Ser Met His Trp Val 
                405                 410                 415     


Arg Gln Ala His Gly Gln Arg Leu Glu Trp Ile Gly Gly Ile Asn Pro 
            420                 425                 430         


Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
        435                 440                 445             


Ile Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser 
    450                 455                 460                 


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Tyr Tyr 
465                 470                 475                 480 


Tyr Gly Tyr Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
                485                 490                 495     


Leu Thr Val Ser Ser Asn Leu Val Pro Met Val Ala Thr Val 
            500                 505                 510 


<210>  118
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein 115754

<400>  118

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Ser Pro Ser Thr 
                245                 250                 255     


Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Ala Ser Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile Tyr Leu Thr Ser Asn 
305                 310                 315                 320 


Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Tyr Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Pro Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
    370                 375                 380                 


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
385                 390                 395                 400 


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Asn Ser Met His Trp Val 
                405                 410                 415     


Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met Gly Gly Ile Asn Pro 
            420                 425                 430         


Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe Gln Gly Arg Val Thr 
        435                 440                 445             


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser 
    450                 455                 460                 


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Tyr Tyr 
465                 470                 475                 480 


Tyr Gly Tyr Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
                485                 490                 495     


Leu Thr Val Ser Ser Asn Leu Val Pro Met Val Ala Thr Val 
            500                 505                 510 


<210>  119
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein 115755

<400>  119

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Ser Pro Ser Thr 
                245                 250                 255     


Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Ala Ser Gln Val Gln Leu 
            260                 265                 270         


Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
        275                 280                 285             


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Asn Ser Met His Trp 
    290                 295                 300                 


Val Arg Gln Ser His Gly Lys Ser Leu Glu Trp Met Gly Gly Ile Asn 
305                 310                 315                 320 


Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Val 
                325                 330                 335     


Thr Met Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg 
            340                 345                 350         


Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Tyr 
        355                 360                 365             


Tyr Tyr Gly Tyr Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
    370                 375                 380                 


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
                405                 410                 415     


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
            420                 425                 430         


Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Tyr 
        435                 440                 445             


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile Tyr Leu 
    450                 455                 460                 


Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp 
                485                 490                 495     


Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Pro Thr Phe 
            500                 505                 510         


Gly Gln Gly Thr Lys Val Glu Ile Lys His His Ala Ala Asn Leu Val 
        515                 520                 525             


Pro Met Val Ala Thr Val 
    530                 


<210>  120
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein 115756

<400>  120

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Ser Pro Ser Thr 
                245                 250                 255     


Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Ala Ser Gln Val Gln Leu 
            260                 265                 270         


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
        275                 280                 285             


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Asn Ser Met His Trp 
    290                 295                 300                 


Val Arg Gln Ala His Gly Gln Arg Leu Glu Trp Ile Gly Gly Ile Asn 
305                 310                 315                 320 


Pro Asn Asn Gly Gly Thr Trp Tyr Asn Arg Lys Phe Lys Gly Lys Ala 
                325                 330                 335     


Ala Ile Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser 
            340                 345                 350         


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Tyr 
        355                 360                 365             


Tyr Tyr Gly Tyr Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
    370                 375                 380                 


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
                405                 410                 415     


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
            420                 425                 430         


Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Tyr 
        435                 440                 445             


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile Tyr Leu 
    450                 455                 460                 


Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp 
                485                 490                 495     


Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Pro Thr Phe 
            500                 505                 510         


Gly Gln Gly Thr Lys Val Glu Ile Lys His His Ala Ala Asn Leu Val 
        515                 520                 525             


Pro Met Val Ala Thr Val 
    530                 


<210>  121
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein 115757

<400>  121

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Ser Pro Ser Thr 
                245                 250                 255     


Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Ala Ser Gln Val Gln Leu 
            260                 265                 270         


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
        275                 280                 285             


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Asn Ser Met His Trp 
    290                 295                 300                 


Val Arg Gln Ala His Gly Gln Arg Leu Glu Trp Ile Gly Gly Ile Asn 
305                 310                 315                 320 


Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala 
                325                 330                 335     


Thr Ile Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser 
            340                 345                 350         


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Tyr 
        355                 360                 365             


Tyr Tyr Gly Tyr Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
    370                 375                 380                 


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
                405                 410                 415     


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
            420                 425                 430         


Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Tyr 
        435                 440                 445             


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile Tyr Leu 
    450                 455                 460                 


Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp 
                485                 490                 495     


Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Pro Thr Phe 
            500                 505                 510         


Gly Gln Gly Thr Lys Val Glu Ile Lys His His Ala Ala Asn Leu Val 
        515                 520                 525             


Pro Met Val Ala Thr Val 
    530                 


<210>  122
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein 115758

<400>  122

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Ser Pro Ser Thr 
                245                 250                 255     


Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Ala Ser Gln Val Gln Leu 
            260                 265                 270         


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
        275                 280                 285             


Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Asn Ser Met His Trp 
    290                 295                 300                 


Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met Gly Gly Ile Asn 
305                 310                 315                 320 


Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe Gln Gly Arg Val 
                325                 330                 335     


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser 
            340                 345                 350         


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Tyr 
        355                 360                 365             


Tyr Tyr Gly Tyr Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
    370                 375                 380                 


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
                405                 410                 415     


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
            420                 425                 430         


Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Tyr 
        435                 440                 445             


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile Tyr Leu 
    450                 455                 460                 


Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp 
                485                 490                 495     


Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Pro Thr Phe 
            500                 505                 510         


Gly Gln Gly Thr Lys Val Glu Ile Lys His His Ala Ala Asn Leu Val 
        515                 520                 525             


Pro Met Val Ala Thr Val 
    530                 


<210>  123
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein 115961

<400>  123

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu 
            260                 265                 270         


Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile 
        275                 280                 285             


Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp 
    290                 295                 300                 


Val Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn 
305                 310                 315                 320 


Pro Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala 
                325                 330                 335     


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg 
            340                 345                 350         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr 
        355                 360                 365             


Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
    370                 375                 380                 


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
                405                 410                 415     


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
            420                 425                 430         


Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
        435                 440                 445             


Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu 
    450                 455                 460                 


Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp 
                485                 490                 495     


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe 
            500                 505                 510         


Gly Gly Gly Thr Lys Leu Glu Leu Lys 
        515                 520     


<210>  124
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein 115962

<400>  124

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu 
            260                 265                 270         


Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile 
        275                 280                 285             


Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp 
    290                 295                 300                 


Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn 
305                 310                 315                 320 


Pro Asn Asn Gly Gly Thr Trp Tyr Asn Arg Lys Phe Lys Gly Lys Ala 
                325                 330                 335     


Ala Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg 
            340                 345                 350         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr 
        355                 360                 365             


Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
    370                 375                 380                 


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
                405                 410                 415     


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
            420                 425                 430         


Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
        435                 440                 445             


Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu 
    450                 455                 460                 


Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp 
                485                 490                 495     


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe 
            500                 505                 510         


Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        515                 520     


<210>  125
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein 116187

<400>  125

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu 
            260                 265                 270         


Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile 
        275                 280                 285             


Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp 
    290                 295                 300                 


Val Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn 
305                 310                 315                 320 


Pro Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala 
                325                 330                 335     


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg 
            340                 345                 350         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr 
        355                 360                 365             


Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
    370                 375                 380                 


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
385                 390                 395                 400 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                405                 410                 415     


Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln 
            420                 425                 430         


Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu Thr Ser Asn Leu 
        435                 440                 445             


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
    450                 455                 460                 


Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr 
465                 470                 475                 480 


Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr 
                485                 490                 495     


Lys Leu Glu Ile Lys 
            500     


<210>  126
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein 116188

<400>  126

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu 
            260                 265                 270         


Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile 
        275                 280                 285             


Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp 
    290                 295                 300                 


Val Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn 
305                 310                 315                 320 


Pro Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala 
                325                 330                 335     


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg 
            340                 345                 350         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr 
        355                 360                 365             


Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
    370                 375                 380                 


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
385                 390                 395                 400 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                405                 410                 415     


Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln 
            420                 425                 430         


Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu Thr Ser Asn Leu 
        435                 440                 445             


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
    450                 455                 460                 


Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr 
465                 470                 475                 480 


Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr 
                485                 490                 495     


Lys Leu Glu Ile Lys His His Ala Ala Asn Leu Val Pro Met Val Ala 
            500                 505                 510         


Thr Val 
        


<210>  127
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein 116296

<400>  127

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu 
            260                 265                 270         


Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile 
        275                 280                 285             


Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp 
    290                 295                 300                 


Val Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn 
305                 310                 315                 320 


Pro Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala 
                325                 330                 335     


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg 
            340                 345                 350         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr 
        355                 360                 365             


Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
    370                 375                 380                 


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
385                 390                 395                 400 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                405                 410                 415     


Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln 
            420                 425                 430         


Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu Thr Ser Asn Leu 
        435                 440                 445             


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
    450                 455                 460                 


Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr 
465                 470                 475                 480 


Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr 
                485                 490                 495     


Lys Leu Glu Leu Lys 
            500     


<210>  128

<400>  128
000

<210>  129
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein 116299

<400>  129

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu 
            260                 265                 270         


Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile 
        275                 280                 285             


Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp 
    290                 295                 300                 


Val Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn 
305                 310                 315                 320 


Pro Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala 
                325                 330                 335     


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg 
            340                 345                 350         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr 
        355                 360                 365             


Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
    370                 375                 380                 


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                405                 410                 415     


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            420                 425                 430         


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        435                 440                 445             


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    450                 455                 460                 


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
465                 470                 475                 480 


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                485                 490                 495     


Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys His His Ala Ala Asn Leu 
            500                 505                 510         


Val Pro Met Val Ala Thr Val 
        515                 


<210>  130
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein 116324

<400>  130

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu 
            260                 265                 270         


Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile 
        275                 280                 285             


Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp 
    290                 295                 300                 


Val Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn 
305                 310                 315                 320 


Pro Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala 
                325                 330                 335     


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg 
            340                 345                 350         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr 
        355                 360                 365             


Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
    370                 375                 380                 


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
                405                 410                 415     


Ile Val Met Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu 
            420                 425                 430         


Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
        435                 440                 445             


Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu 
    450                 455                 460                 


Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp 
                485                 490                 495     


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe 
            500                 505                 510         


Gly Gly Gly Thr Lys Leu Glu Leu Lys His His Ala Ala Asn Leu Val 
        515                 520                 525             


Pro Met Val Ala Thr Val 
    530                 


<210>  131
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein 116325

<400>  131

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu 
            260                 265                 270         


Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile 
        275                 280                 285             


Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp 
    290                 295                 300                 


Val Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn 
305                 310                 315                 320 


Pro Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala 
                325                 330                 335     


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg 
            340                 345                 350         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr 
        355                 360                 365             


Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
    370                 375                 380                 


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr 
385                 390                 395                 400 


Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
                405                 410                 415     


Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln 
            420                 425                 430         


Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu Thr Ser Asn Leu 
        435                 440                 445             


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
    450                 455                 460                 


Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr 
465                 470                 475                 480 


Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr 
                485                 490                 495     


Lys Leu Glu Leu Lys His His Ala Ala Asn Leu Val Pro Met Val Ala 
            500                 505                 510         


Thr Val 
        


<210>  132
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein #1

<400>  132

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Cys Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln 
    290                 295                 300                 


Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu Thr Ser Asn Leu 
305                 310                 315                 320 


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
                325                 330                 335     


Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr 
            340                 345                 350         


Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr 
        355                 360                 365             


Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Glu Val His Leu Val Glu 
    370                 375                 380                 


Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys 
385                 390                 395                 400 


Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp Val Lys 
                405                 410                 415     


Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asp Pro Asn 
            420                 425                 430         


Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu 
        435                 440                 445             


Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu 
    450                 455                 460                 


Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr Tyr Tyr 
465                 470                 475                 480 


Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
                485                 490                 495     


Thr Val Ser Ser Asn Leu Val Pro Met Val Ala Thr Val 
            500                 505                 


<210>  133
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein #2

<400>  133

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Cys Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln 
    290                 295                 300                 


Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu Thr Ser Asn Leu 
305                 310                 315                 320 


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
                325                 330                 335     


Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr 
            340                 345                 350         


Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr 
        355                 360                 365             


Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln 
    370                 375                 380                 


Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys 
385                 390                 395                 400 


Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp Val Lys 
                405                 410                 415     


Gln Arg His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn Pro Asn 
            420                 425                 430         


Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu 
        435                 440                 445             


Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu 
    450                 455                 460                 


Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr Tyr Tyr 
465                 470                 475                 480 


Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
                485                 490                 495     


Thr Val Ser Ser Asn Leu Val Pro Met Val Ala Thr Val 
            500                 505                 


<210>  134
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein #3

<400>  134

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Cys Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln 
    290                 295                 300                 


Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu Thr Ser Asn Leu 
305                 310                 315                 320 


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
                325                 330                 335     


Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr 
            340                 345                 350         


Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr 
        355                 360                 365             


Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln 
    370                 375                 380                 


Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys 
385                 390                 395                 400 


Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp Val Lys 
                405                 410                 415     


Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn Pro Asn 
            420                 425                 430         


Asn Gly Gly Thr Trp Tyr Asn Arg Lys Phe Lys Gly Lys Ala Ala Leu 
        435                 440                 445             


Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu 
    450                 455                 460                 


Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr Tyr Tyr 
465                 470                 475                 480 


Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
                485                 490                 495     


Thr Val Ser Ser Asn Leu Val Pro Met Val Ala Thr Val 
            500                 505                 


<210>  135
<211>  533
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein #4

<400>  135

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu Gln 
            260                 265                 270         


Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser 
        275                 280                 285             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Asn Ser Met His Trp Val 
    290                 295                 300                 


Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn Pro 
305                 310                 315                 320 


Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Phe Arg Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Pro Tyr Tyr 
        355                 360                 365             


Tyr Gly Tyr Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
    370                 375                 380                 


Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
                405                 410                 415     


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
            420                 425                 430         


Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp 
        435                 440                 445             


Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu Thr 
    450                 455                 460                 


Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
465                 470                 475                 480 


Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala 
                485                 490                 495     


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Pro Thr Phe Gly 
            500                 505                 510         


Gly Gly Thr Lys Leu Glu Ile Lys His His Ala Ala Asn Leu Val Pro 
        515                 520                 525             


Met Val Ala Thr Val 
    530             


<210>  136
<211>  533
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein #5

<400>  136

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val His Leu Val 
            260                 265                 270         


Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser 
        275                 280                 285             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp Val 
    290                 295                 300                 


Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asp Pro 
305                 310                 315                 320 


Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr Tyr 
        355                 360                 365             


Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
    370                 375                 380                 


Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
                405                 410                 415     


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
            420                 425                 430         


Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp 
        435                 440                 445             


Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu Thr 
    450                 455                 460                 


Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
465                 470                 475                 480 


Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala 
                485                 490                 495     


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe Gly 
            500                 505                 510         


Gly Gly Thr Lys Leu Glu Ile Lys His His Ala Ala Asn Leu Val Pro 
        515                 520                 525             


Met Val Ala Thr Val 
    530             


<210>  137
<211>  533
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein #6

<400>  137

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu Gln 
            260                 265                 270         


Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser 
        275                 280                 285             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp Val 
    290                 295                 300                 


Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn Pro 
305                 310                 315                 320 


Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr Tyr 
        355                 360                 365             


Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
    370                 375                 380                 


Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
                405                 410                 415     


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
            420                 425                 430         


Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp 
        435                 440                 445             


Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu Thr 
    450                 455                 460                 


Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
465                 470                 475                 480 


Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala 
                485                 490                 495     


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe Gly 
            500                 505                 510         


Gly Gly Thr Lys Leu Glu Leu Lys His His Ala Ala Asn Leu Val Pro 
        515                 520                 525             


Met Val Ala Thr Val 
    530             


<210>  138
<211>  533
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein #7

<400>  138

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu Gln 
            260                 265                 270         


Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser 
        275                 280                 285             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp Val 
    290                 295                 300                 


Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn Pro 
305                 310                 315                 320 


Asn Asn Gly Gly Thr Trp Tyr Asn Arg Lys Phe Lys Gly Lys Ala Ala 
                325                 330                 335     


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr Tyr 
        355                 360                 365             


Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
    370                 375                 380                 


Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
                405                 410                 415     


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
            420                 425                 430         


Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp 
        435                 440                 445             


Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu Thr 
    450                 455                 460                 


Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
465                 470                 475                 480 


Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala 
                485                 490                 495     


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe Gly 
            500                 505                 510         


Gly Gly Thr Lys Leu Glu Ile Lys His His Ala Ala Asn Leu Val Pro 
        515                 520                 525             


Met Val Ala Thr Val 
    530             


<210>  139
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein #8

<400>  139

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Ser Pro Ser Thr Pro 
                245                 250                 255     


Pro Thr Pro Ser Pro Ser Thr Pro Pro Ala Ser Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln 
    290                 295                 300                 


Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile Tyr Leu Thr Ser Asn Leu 
305                 310                 315                 320 


Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                325                 330                 335     


Tyr Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr 
            340                 345                 350         


Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Pro Thr Phe Gly Gln Gly Thr 
        355                 360                 365             


Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln 
    370                 375                 380                 


Ser Gly Pro Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys 
385                 390                 395                 400 


Lys Ala Ser Gly Tyr Thr Phe Thr Glu Asn Ser Met His Trp Val Arg 
                405                 410                 415     


Gln Ser His Gly Lys Ser Leu Glu Trp Met Gly Gly Ile Asn Pro Asn 
            420                 425                 430         


Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Val Thr Met 
        435                 440                 445             


Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu 
    450                 455                 460                 


Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Tyr Tyr Tyr 
465                 470                 475                 480 


Gly Tyr Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
                485                 490                 495     


Thr Val Ser Ser Asn Leu Val Pro Met Val Ala Thr Val 
            500                 505                 


<210>  140
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein #9

<400>  140

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Ser Pro Ser Thr Pro 
                245                 250                 255     


Pro Thr Pro Ser Pro Ser Thr Pro Pro Ala Ser Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln 
    290                 295                 300                 


Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile Tyr Leu Thr Ser Asn Leu 
305                 310                 315                 320 


Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                325                 330                 335     


Tyr Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr 
            340                 345                 350         


Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Pro Thr Phe Gly Gln Gly Thr 
        355                 360                 365             


Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln 
    370                 375                 380                 


Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys 
385                 390                 395                 400 


Lys Ala Ser Gly Tyr Thr Phe Thr Glu Asn Ser Met His Trp Val Arg 
                405                 410                 415     


Gln Ala His Gly Gln Arg Leu Glu Trp Ile Gly Gly Ile Asn Pro Asn 
            420                 425                 430         


Asn Gly Gly Thr Trp Tyr Asn Arg Lys Phe Lys Gly Lys Ala Ala Ile 
        435                 440                 445             


Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu 
    450                 455                 460                 


Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Tyr Tyr Tyr 
465                 470                 475                 480 


Gly Tyr Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
                485                 490                 495     


Thr Val Ser Ser Asn Leu Val Pro Met Val Ala Thr Val 
            500                 505                 


<210>  141
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein #10

<400>  141

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Ser Pro Ser Thr Pro 
                245                 250                 255     


Pro Thr Pro Ser Pro Ser Thr Pro Pro Ala Ser Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln 
    290                 295                 300                 


Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile Tyr Leu Thr Ser Asn Leu 
305                 310                 315                 320 


Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                325                 330                 335     


Tyr Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr 
            340                 345                 350         


Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Pro Thr Phe Gly Gln Gly Thr 
        355                 360                 365             


Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln 
    370                 375                 380                 


Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys 
385                 390                 395                 400 


Lys Ala Ser Gly Tyr Thr Phe Thr Glu Asn Ser Met His Trp Val Arg 
                405                 410                 415     


Gln Ala His Gly Gln Arg Leu Glu Trp Ile Gly Gly Ile Asn Pro Asn 
            420                 425                 430         


Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Ile 
        435                 440                 445             


Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu 
    450                 455                 460                 


Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Tyr Tyr Tyr 
465                 470                 475                 480 


Gly Tyr Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
                485                 490                 495     


Thr Val Ser Ser Asn Leu Val Pro Met Val Ala Thr Val 
            500                 505                 


<210>  142
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein #11

<400>  142

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Ser Pro Ser Thr Pro 
                245                 250                 255     


Pro Thr Pro Ser Pro Ser Thr Pro Pro Ala Ser Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln 
    290                 295                 300                 


Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile Tyr Leu Thr Ser Asn Leu 
305                 310                 315                 320 


Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                325                 330                 335     


Tyr Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr 
            340                 345                 350         


Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Pro Thr Phe Gly Gln Gly Thr 
        355                 360                 365             


Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln 
    370                 375                 380                 


Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys 
385                 390                 395                 400 


Lys Thr Ser Gly Tyr Thr Phe Thr Glu Asn Ser Met His Trp Val Arg 
                405                 410                 415     


Gln Ala Pro Gly Gln Arg Leu Glu Trp Met Gly Gly Ile Asn Pro Asn 
            420                 425                 430         


Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe Gln Gly Arg Val Thr Leu 
        435                 440                 445             


Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu 
    450                 455                 460                 


Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Tyr Tyr Tyr 
465                 470                 475                 480 


Gly Tyr Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
                485                 490                 495     


Thr Val Ser Ser Asn Leu Val Pro Met Val Ala Thr Val 
            500                 505                 


<210>  143
<211>  533
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein #12

<400>  143

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Ser Pro Ser Thr Pro 
                245                 250                 255     


Pro Thr Pro Ser Pro Ser Thr Pro Pro Ala Ser Gln Val Gln Leu Val 
            260                 265                 270         


Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Asn Ser Met His Trp Val 
    290                 295                 300                 


Arg Gln Ser His Gly Lys Ser Leu Glu Trp Met Gly Gly Ile Asn Pro 
305                 310                 315                 320 


Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Val Thr 
                325                 330                 335     


Met Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser 
            340                 345                 350         


Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Tyr Tyr 
        355                 360                 365             


Tyr Gly Tyr Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
    370                 375                 380                 


Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
                405                 410                 415     


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
            420                 425                 430         


Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp 
        435                 440                 445             


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile Tyr Leu Thr 
    450                 455                 460                 


Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser 
465                 470                 475                 480 


Gly Thr Asp Tyr Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe 
                485                 490                 495     


Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Pro Thr Phe Gly 
            500                 505                 510         


Gln Gly Thr Lys Val Glu Ile Lys His His Ala Ala Asn Leu Val Pro 
        515                 520                 525             


Met Val Ala Thr Val 
    530             


<210>  144
<211>  533
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein #13

<400>  144

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Ser Pro Ser Thr Pro 
                245                 250                 255     


Pro Thr Pro Ser Pro Ser Thr Pro Pro Ala Ser Gln Val Gln Leu Val 
            260                 265                 270         


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Asn Ser Met His Trp Val 
    290                 295                 300                 


Arg Gln Ala His Gly Gln Arg Leu Glu Trp Ile Gly Gly Ile Asn Pro 
305                 310                 315                 320 


Asn Asn Gly Gly Thr Trp Tyr Asn Arg Lys Phe Lys Gly Lys Ala Ala 
                325                 330                 335     


Ile Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser 
            340                 345                 350         


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Tyr Tyr 
        355                 360                 365             


Tyr Gly Tyr Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
    370                 375                 380                 


Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
                405                 410                 415     


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
            420                 425                 430         


Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp 
        435                 440                 445             


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile Tyr Leu Thr 
    450                 455                 460                 


Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser 
465                 470                 475                 480 


Gly Thr Asp Tyr Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe 
                485                 490                 495     


Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Pro Thr Phe Gly 
            500                 505                 510         


Gln Gly Thr Lys Val Glu Ile Lys His His Ala Ala Asn Leu Val Pro 
        515                 520                 525             


Met Val Ala Thr Val 
    530             


<210>  145
<211>  533
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein #14

<400>  145

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Ser Pro Ser Thr Pro 
                245                 250                 255     


Pro Thr Pro Ser Pro Ser Thr Pro Pro Ala Ser Gln Val Gln Leu Val 
            260                 265                 270         


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Asn Ser Met His Trp Val 
    290                 295                 300                 


Arg Gln Ala His Gly Gln Arg Leu Glu Trp Ile Gly Gly Ile Asn Pro 
305                 310                 315                 320 


Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Ile Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser 
            340                 345                 350         


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Tyr Tyr 
        355                 360                 365             


Tyr Gly Tyr Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
    370                 375                 380                 


Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
                405                 410                 415     


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
            420                 425                 430         


Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp 
        435                 440                 445             


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile Tyr Leu Thr 
    450                 455                 460                 


Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser 
465                 470                 475                 480 


Gly Thr Asp Tyr Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe 
                485                 490                 495     


Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Pro Thr Phe Gly 
            500                 505                 510         


Gln Gly Thr Lys Val Glu Ile Lys His His Ala Ala Asn Leu Val Pro 
        515                 520                 525             


Met Val Ala Thr Val 
    530             


<210>  146
<211>  533
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein #15

<400>  146

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Ser Pro Ser Thr Pro 
                245                 250                 255     


Pro Thr Pro Ser Pro Ser Thr Pro Pro Ala Ser Gln Val Gln Leu Val 
            260                 265                 270         


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
        275                 280                 285             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Asn Ser Met His Trp Val 
    290                 295                 300                 


Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met Gly Gly Ile Asn Pro 
305                 310                 315                 320 


Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe Gln Gly Arg Val Thr 
                325                 330                 335     


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser 
            340                 345                 350         


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Tyr Tyr 
        355                 360                 365             


Tyr Gly Tyr Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
    370                 375                 380                 


Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
                405                 410                 415     


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
            420                 425                 430         


Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp 
        435                 440                 445             


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile Tyr Leu Thr 
    450                 455                 460                 


Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser 
465                 470                 475                 480 


Gly Thr Asp Tyr Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe 
                485                 490                 495     


Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Pro Thr Phe Gly 
            500                 505                 510         


Gln Gly Thr Lys Val Glu Ile Lys His His Ala Ala Asn Leu Val Pro 
        515                 520                 525             


Met Val Ala Thr Val 
    530             


<210>  147
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein #16

<400>  147

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu Gln 
            260                 265                 270         


Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser 
        275                 280                 285             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp Val 
    290                 295                 300                 


Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn Pro 
305                 310                 315                 320 


Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr Tyr 
        355                 360                 365             


Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
    370                 375                 380                 


Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
                405                 410                 415     


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
            420                 425                 430         


Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp 
        435                 440                 445             


Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu Thr 
    450                 455                 460                 


Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
465                 470                 475                 480 


Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala 
                485                 490                 495     


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe Gly 
            500                 505                 510         


Gly Gly Thr Lys Leu Glu Leu Lys 
        515                 520 


<210>  148
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein #17

<400>  148

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu Gln 
            260                 265                 270         


Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser 
        275                 280                 285             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp Val 
    290                 295                 300                 


Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn Pro 
305                 310                 315                 320 


Asn Asn Gly Gly Thr Trp Tyr Asn Arg Lys Phe Lys Gly Lys Ala Ala 
                325                 330                 335     


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr Tyr 
        355                 360                 365             


Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
    370                 375                 380                 


Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
                405                 410                 415     


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
            420                 425                 430         


Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp 
        435                 440                 445             


Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu Thr 
    450                 455                 460                 


Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
465                 470                 475                 480 


Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala 
                485                 490                 495     


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe Gly 
            500                 505                 510         


Gly Gly Thr Lys Leu Glu Ile Lys 
        515                 520 


<210>  149
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein #18

<400>  149

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu Gln 
            260                 265                 270         


Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser 
        275                 280                 285             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp Val 
    290                 295                 300                 


Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn Pro 
305                 310                 315                 320 


Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr Tyr 
        355                 360                 365             


Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
    370                 375                 380                 


Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
385                 390                 395                 400 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                405                 410                 415     


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys 
            420                 425                 430         


Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu Thr Ser Asn Leu Ala 
        435                 440                 445             


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
    450                 455                 460                 


Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
465                 470                 475                 480 


Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
                485                 490                 495     


Leu Glu Ile Lys 
            500 


<210>  150
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein #19

<400>  150

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu Gln 
            260                 265                 270         


Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser 
        275                 280                 285             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp Val 
    290                 295                 300                 


Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn Pro 
305                 310                 315                 320 


Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr Tyr 
        355                 360                 365             


Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
    370                 375                 380                 


Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
385                 390                 395                 400 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                405                 410                 415     


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys 
            420                 425                 430         


Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu Thr Ser Asn Leu Ala 
        435                 440                 445             


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
    450                 455                 460                 


Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
465                 470                 475                 480 


Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
                485                 490                 495     


Leu Glu Ile Lys His His Ala Ala Asn Leu Val Pro Met Val Ala Thr 
            500                 505                 510         


Val 
    


<210>  151
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein #20

<400>  151

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu Gln 
            260                 265                 270         


Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser 
        275                 280                 285             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp Val 
    290                 295                 300                 


Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn Pro 
305                 310                 315                 320 


Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr Tyr 
        355                 360                 365             


Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
    370                 375                 380                 


Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
385                 390                 395                 400 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                405                 410                 415     


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys 
            420                 425                 430         


Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu Thr Ser Asn Leu Ala 
        435                 440                 445             


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
    450                 455                 460                 


Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
465                 470                 475                 480 


Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
                485                 490                 495     


Leu Glu Leu Lys 
            500 


<210>  152
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein #21

<400>  152

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu Gln 
            260                 265                 270         


Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser 
        275                 280                 285             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp Val 
    290                 295                 300                 


Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn Pro 
305                 310                 315                 320 


Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr Tyr 
        355                 360                 365             


Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
    370                 375                 380                 


Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
385                 390                 395                 400 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                405                 410                 415     


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys 
            420                 425                 430         


Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu Thr Ser Asn Leu Ala 
        435                 440                 445             


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
    450                 455                 460                 


Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
465                 470                 475                 480 


Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
                485                 490                 495     


Leu Glu Leu Lys His His Ala Ala Asn Leu Val Pro Met Val Ala Thr 
            500                 505                 510         


Val 
    


<210>  153
<211>  518
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein #22

<400>  153

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu Gln 
            260                 265                 270         


Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser 
        275                 280                 285             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp Val 
    290                 295                 300                 


Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn Pro 
305                 310                 315                 320 


Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr Tyr 
        355                 360                 365             


Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
    370                 375                 380                 


Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
385                 390                 395                 400 


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
                405                 410                 415     


Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
            420                 425                 430         


Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu 
        435                 440                 445             


Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
    450                 455                 460                 


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp 
465                 470                 475                 480 


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe 
                485                 490                 495     


Gly Gly Gly Thr Lys Leu Glu Leu Lys His His Ala Ala Asn Leu Val 
            500                 505                 510         


Pro Met Val Ala Thr Val 
        515             


<210>  154
<211>  533
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein #23

<400>  154

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu Gln 
            260                 265                 270         


Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser 
        275                 280                 285             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp Val 
    290                 295                 300                 


Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn Pro 
305                 310                 315                 320 


Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr Tyr 
        355                 360                 365             


Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
    370                 375                 380                 


Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
                405                 410                 415     


Val Met Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys 
            420                 425                 430         


Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp 
        435                 440                 445             


Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu Thr 
    450                 455                 460                 


Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
465                 470                 475                 480 


Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala 
                485                 490                 495     


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe Gly 
            500                 505                 510         


Gly Gly Thr Lys Leu Glu Leu Lys His His Ala Ala Asn Leu Val Pro 
        515                 520                 525             


Met Val Ala Thr Val 
    530             


<210>  155
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein #24

<400>  155

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu Gln 
            260                 265                 270         


Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser 
        275                 280                 285             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp Val 
    290                 295                 300                 


Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn Pro 
305                 310                 315                 320 


Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr Tyr 
        355                 360                 365             


Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
    370                 375                 380                 


Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln 
385                 390                 395                 400 


Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr 
                405                 410                 415     


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys 
            420                 425                 430         


Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu Thr Ser Asn Leu Ala 
        435                 440                 445             


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
    450                 455                 460                 


Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
465                 470                 475                 480 


Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
                485                 490                 495     


Leu Glu Leu Lys His His Ala Ala Asn Leu Val Pro Met Val Ala Thr 
            500                 505                 510         


Val 
    


<210>  156
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-chain variable fragment XXIV

<400>  156

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Tyr Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ala Ile Met Ser Ala 
145                 150                 155                 160 


Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val 
                165                 170                 175     


Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro 
            180                 185                 190         


Trp Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met 
    210                 215                 220                 


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn 
225                 230                 235                 240 


Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
                245                 250             


<210>  157
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-chain variable fragment XXV

<400>  157

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Tyr Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Asp 
        115                 120                 125             


Ile Val Met Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu 
    130                 135                 140                 


Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
145                 150                 155                 160 


Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu 
                165                 170                 175     


Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
            180                 185                 190         


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp 
        195                 200                 205             


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe 
    210                 215                 220                 


Gly Gly Gly Thr Lys Leu Glu Leu Lys 
225                 230             


<210>  158
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein #25

<400>  158

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Ser Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Asp Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu Gln 
            260                 265                 270         


Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser 
        275                 280                 285             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp Val 
    290                 295                 300                 


Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn Pro 
305                 310                 315                 320 


Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr Tyr 
        355                 360                 365             


Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
    370                 375                 380                 


Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
385                 390                 395                 400 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                405                 410                 415     


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys 
            420                 425                 430         


Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu Thr Ser Asn Leu Ala 
        435                 440                 445             


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
    450                 455                 460                 


Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
465                 470                 475                 480 


Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
                485                 490                 495     


Leu Glu Leu Lys His His Ala Ala Asn Leu Val Pro Met Val Ala Thr 
            500                 505                 510         


Val 
    


<210>  159
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding protein #26

<400>  159

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Ser Pro Ser Thr Pro 
                245                 250                 255     


Pro Thr Pro Ser Pro Ser Thr Pro Pro Ala Ser Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr Asn Arg Val Ser 
    290                 295                 300                 


Trp Tyr Gln Gln Pro Pro Gly Thr Ala Pro Lys Leu Met Ile Tyr Glu 
305                 310                 315                 320 


Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe Ser Gly Ser Lys 
                325                 330                 335     


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
            340                 345                 350         


Glu Ala Asp Tyr Tyr Cys Ser Ser His Thr Thr Ser Gly Thr Tyr Val 
        355                 360                 365             


Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Glu 
    370                 375                 380                 


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
385                 390                 395                 400 


Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr Ala 
                405                 410                 415     


Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
            420                 425                 430         


Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
        435                 440                 445             


Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met 
    450                 455                 460                 


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
465                 470                 475                 480 


Arg Asp Gln Gly Tyr Ala His Ala Phe Asp Ile Trp Gly Arg Gly Thr 
                485                 490                 495     


Thr Val Thr Val Ser Ser His His Ala Ala Asn Leu Val Pro Met Val 
            500                 505                 510         


Ala Thr Val Arg Arg Asn Leu Val Pro Met Val Ala Thr Val Arg Arg 
        515                 520                 525             


Asn Leu Val Pro 
    530         


<210>  160
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Binding Molecule 116555

<400>  160

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Ser Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Asp Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu 
            260                 265                 270         


Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile 
        275                 280                 285             


Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp 
    290                 295                 300                 


Val Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn 
305                 310                 315                 320 


Pro Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala 
                325                 330                 335     


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg 
            340                 345                 350         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr 
        355                 360                 365             


Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
    370                 375                 380                 


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
385                 390                 395                 400 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                405                 410                 415     


Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln 
            420                 425                 430         


Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu Thr Ser Asn Leu 
        435                 440                 445             


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
    450                 455                 460                 


Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr 
465                 470                 475                 480 


Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr 
                485                 490                 495     


Lys Leu Glu Leu Lys His His Ala Ala Asn Leu Val Pro Met Val Ala 
            500                 505                 510         


Thr Val 
        


<210>  161
<211>  533
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Binding Molecule 115765

<400>  161

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Ser Pro Ser Thr 
                245                 250                 255     


Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Ala Ser Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr Asn Arg Val 
    290                 295                 300                 


Ser Trp Tyr Gln Gln Pro Pro Gly Thr Ala Pro Lys Leu Met Ile Tyr 
305                 310                 315                 320 


Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe Ser Gly Ser 
                325                 330                 335     


Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu 
            340                 345                 350         


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser His Thr Thr Ser Gly Thr Tyr 
        355                 360                 365             


Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser 
    370                 375                 380                 


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
385                 390                 395                 400 


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
                405                 410                 415     


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
            420                 425                 430         


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
        435                 440                 445             


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
    450                 455                 460                 


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
465                 470                 475                 480 


Ala Arg Asp Gln Gly Tyr Ala His Ala Phe Asp Ile Trp Gly Arg Gly 
                485                 490                 495     


Thr Thr Val Thr Val Ser Ser His His Ala Ala Asn Leu Val Pro Met 
            500                 505                 510         


Val Ala Thr Val Arg Arg Asn Leu Val Pro Met Val Ala Thr Val Arg 
        515                 520                 525             


Arg Asn Leu Val Pro 
    530             


<210>  162
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Binding Molecule 115695

<400>  162

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Ser Pro Ser Thr 
                245                 250                 255     


Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Ala Ser Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr Asn Arg Val 
    290                 295                 300                 


Ser Trp Tyr Gln Gln Pro Pro Gly Thr Ala Pro Lys Leu Met Ile Tyr 
305                 310                 315                 320 


Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe Ser Gly Ser 
                325                 330                 335     


Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu 
            340                 345                 350         


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser His Thr Thr Ser Gly Thr Tyr 
        355                 360                 365             


Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser 
    370                 375                 380                 


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
385                 390                 395                 400 


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
                405                 410                 415     


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
            420                 425                 430         


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
        435                 440                 445             


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
    450                 455                 460                 


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
465                 470                 475                 480 


Ala Arg Asp Gln Gly Tyr Ala His Ala Phe Asp Ile Trp Gly Arg Gly 
                485                 490                 495     


Thr Thr Val Thr Val Ser Ser 
            500             


<210>  163
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Binding Molecule 114895

<400>  163

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Val Leu 
            260                 265                 270         


Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr 
        275                 280                 285             


Ile Ser Cys Arg Ala Thr Glu Ser Val Glu Tyr Tyr Gly Thr Ser Leu 
    290                 295                 300                 


Val Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
305                 310                 315                 320 


Tyr Ala Ala Ser Ser Val Asp Ser Gly Val Pro Ala Arg Phe Ser Gly 
                325                 330                 335     


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile His Pro Val Glu Glu 
            340                 345                 350         


Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg Arg Val Pro Tyr 
        355                 360                 365             


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
    370                 375                 380                 


Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
385                 390                 395                 400 


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
                405                 410                 415     


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
            420                 425                 430         


Gly Tyr Val Asn Pro Phe Asn Asp Gly Thr Lys Tyr Asn Glu Met Phe 
        435                 440                 445             


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
    450                 455                 460                 


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
465                 470                 475                 480 


Ala Arg Gln Ala Trp Gly Tyr Pro Trp Gly Gln Gly Thr Leu Val Thr 
                485                 490                 495     


Val Ser Ala Asn Leu Val Pro Met Val Ala Thr Val 
            500                 505             


<210>  164
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Binding molecule V1

<400>  164

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu 
            260                 265                 270         


Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile 
        275                 280                 285             


Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp 
    290                 295                 300                 


Val Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn 
305                 310                 315                 320 


Pro Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala 
                325                 330                 335     


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg 
            340                 345                 350         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr 
        355                 360                 365             


Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
    370                 375                 380                 


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
385                 390                 395                 400 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                405                 410                 415     


Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln 
            420                 425                 430         


Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu Thr Ser Asn Leu 
        435                 440                 445             


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
    450                 455                 460                 


Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr 
465                 470                 475                 480 


Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr 
                485                 490                 495     


Lys Leu Glu Leu Lys Asn Leu Val Pro Met Val Ala Thr Val Arg Arg 
            500                 505                 510         


Asn Leu Val Pro Met Val Ala Thr Val Arg Arg Asn Leu Val Pro Met 
        515                 520                 525             


Val Ala Thr Val 
    530         


<210>  165
<211>  527
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Binding molecule V2

<400>  165

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu 
            260                 265                 270         


Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile 
        275                 280                 285             


Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp 
    290                 295                 300                 


Val Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn 
305                 310                 315                 320 


Pro Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala 
                325                 330                 335     


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg 
            340                 345                 350         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr 
        355                 360                 365             


Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
    370                 375                 380                 


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
385                 390                 395                 400 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                405                 410                 415     


Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln 
            420                 425                 430         


Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu Thr Ser Asn Leu 
        435                 440                 445             


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
    450                 455                 460                 


Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr 
465                 470                 475                 480 


Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr 
                485                 490                 495     


Lys Leu Glu Leu Lys Asn Leu Val Pro Met Val Ala Thr Val Arg Arg 
            500                 505                 510         


Asn Leu Val Pro Met Val Ala Thr Val Arg Arg Asn Leu Val Pro 
        515                 520                 525         


<210>  166
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 Binding protein #27

<400>  166

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Ser Pro Ser Thr Pro 
                245                 250                 255     


Pro Thr Pro Ser Pro Ser Thr Pro Pro Ala Ser Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr Asn Arg Val Ser 
    290                 295                 300                 


Trp Tyr Gln Gln Pro Pro Gly Thr Ala Pro Lys Leu Met Ile Tyr Glu 
305                 310                 315                 320 


Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe Ser Gly Ser Lys 
                325                 330                 335     


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
            340                 345                 350         


Glu Ala Asp Tyr Tyr Cys Ser Ser His Thr Thr Ser Gly Thr Tyr Val 
        355                 360                 365             


Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Glu 
    370                 375                 380                 


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
385                 390                 395                 400 


Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr Ala 
                405                 410                 415     


Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
            420                 425                 430         


Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
        435                 440                 445             


Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met 
    450                 455                 460                 


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
465                 470                 475                 480 


Arg Asp Gln Gly Tyr Ala His Ala Phe Asp Ile Trp Gly Arg Gly Thr 
                485                 490                 495     


Thr Val Thr Val Ser Ser 
            500         


<210>  167
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 Binding Protein #28

<400>  167

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Val Leu Thr 
            260                 265                 270         


Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile 
        275                 280                 285             


Ser Cys Arg Ala Thr Glu Ser Val Glu Tyr Tyr Gly Thr Ser Leu Val 
    290                 295                 300                 


Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
305                 310                 315                 320 


Ala Ala Ser Ser Val Asp Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
                325                 330                 335     


Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile His Pro Val Glu Glu Asp 
            340                 345                 350         


Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg Arg Val Pro Tyr Thr 
        355                 360                 365             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Glu 
    370                 375                 380                 


Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
385                 390                 395                 400 


Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val 
                405                 410                 415     


Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly 
            420                 425                 430         


Tyr Val Asn Pro Phe Asn Asp Gly Thr Lys Tyr Asn Glu Met Phe Lys 
        435                 440                 445             


Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr Met 
    450                 455                 460                 


Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
465                 470                 475                 480 


Arg Gln Ala Trp Gly Tyr Pro Trp Gly Gln Gly Thr Leu Val Thr Val 
                485                 490                 495     


Ser Ala Asn Leu Val Pro Met Val Ala Thr Val 
            500                 505         


<210>  168
<211>  531
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Binding Molecule V3

<400>  168

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu 
            260                 265                 270         


Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile 
        275                 280                 285             


Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp 
    290                 295                 300                 


Val Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn 
305                 310                 315                 320 


Pro Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala 
                325                 330                 335     


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg 
            340                 345                 350         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr 
        355                 360                 365             


Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
    370                 375                 380                 


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
385                 390                 395                 400 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                405                 410                 415     


Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln 
            420                 425                 430         


Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu Thr Ser Asn Leu 
        435                 440                 445             


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
    450                 455                 460                 


Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr 
465                 470                 475                 480 


Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr 
                485                 490                 495     


Lys Leu Glu Leu Lys His His Ala Ala Asn Leu Val Pro Met Val Ala 
            500                 505                 510         


Thr Val Arg Arg Asn Leu Val Pro Met Val Ala Thr Val Arg Arg Asn 
        515                 520                 525             


Leu Val Pro 
    530     


<210>  169
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin effector polypeptide 30

<400>  169

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Ser Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Asp Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  170
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin effector polypeptide 31

<400>  170

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Cys Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  171

<400>  171
000

<210>  172

<400>  172
000

<210>  173
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Shiga toxin effector polypeptide 30

<400>  173

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Asp Ala Leu Ser Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210>  174
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carboxy-terminal moiety

<400>  174

Asn Leu Val Pro Met Val Ala Thr Val Arg Arg Asn Leu Val Pro Met 
1               5                   10                  15      


Val Ala Thr Val Arg Arg Asn Leu Val Pro 
            20                  25      


<210>  175
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carboxy-terminal moiety

<400>  175

Asn Leu Val Pro Met Val Ala Thr Val Arg Arg Asn Leu Val Pro Met 
1               5                   10                  15      


Val Ala Thr Val Arg Arg Asn Leu Val Pro Met Val Ala Thr Val 
            20                  25                  30      


<210>  176
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carboxy-terminal moiety

<400>  176

His His Ala Ala Asn Leu Val Pro Met Val Ala Thr Val 
1               5                   10              


<210>  177
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carboxy-terminal moiety

<400>  177

His His Ala Ala Asn Leu Val Pro Met Val Ala Thr Val Arg Arg Asn 
1               5                   10                  15      


Leu Val Pro Met Val Ala Thr Val Arg Arg Asn Leu Val Pro 
            20                  25                  30  


<210>  178
<211>  20
<212>  PRT
<213>  Unknown

<220>
<223>  Carboxy-terminal moiety

<400>  178

Asn Leu Val Pro Met Val Ala Thr Val Arg Arg Asn Leu Val Pro Met 
1               5                   10                  15      


Val Ala Thr Val 
            20  


<210>  179
<211>  22
<212>  PRT
<213>  Unknown

<220>
<223>  Carboxy-terminal moiety

<400>  179

Asn Leu Val Pro Met Val Ala Thr Val His His Ala Ala Asn Leu Val 
1               5                   10                  15      


Pro Met Val Ala Thr Val 
            20          


<210>  180
<211>  11
<212>  PRT
<213>  Unknown

<220>
<223>  Carboxy-terminal moiety

<400>  180

Arg Arg Asn Leu Val Pro Met Val Ala Thr Val 
1               5                   10      


<210>  181
<211>  28
<212>  PRT
<213>  Unknown

<220>
<223>  Carboxy-terminal moiety

<400>  181

Arg Arg Asn Leu Val Pro Met Val Ala Thr Val Arg Arg Asn Leu Val 
1               5                   10                  15      


Pro Met Val Ala Thr Val Arg Arg Asn Leu Val Pro 
            20                  25              


<210>  182
<211>  33
<212>  PRT
<213>  Unknown

<220>
<223>  Carboxy-terminal moiety

<400>  182

Asn Leu Val Pro Met Val Ala Thr Val Arg Arg Asn Leu Val Pro Met 
1               5                   10                  15      


Val Ala Thr Val His His Ala Ala Asn Leu Val Pro Met Val Ala Thr 
            20                  25                  30          


Val 
    


<210>  183
<211>  30
<212>  PRT
<213>  Unknown

<220>
<223>  Carboxy-terminal moiety

<400>  183

Asn Leu Val Pro Met Val Ala Thr Val Arg Arg Ala Ala Asn Leu Val 
1               5                   10                  15      


Pro Met Val Ala Thr Val His His Ala Ala Asn Leu Val Pro 
            20                  25                  30  


<210>  184
<211>  33
<212>  PRT
<213>  Unknown

<220>
<223>  Carboxy-terminal moiety

<400>  184

Asn Leu Val Pro Met Val Ala Thr Val His His Ala Ala Asn Leu Val 
1               5                   10                  15      


Pro Met Val Ala Thr Val Arg Arg Asn Leu Val Pro Met Val Ala Thr 
            20                  25                  30          


Val 
    


<210>  185
<211>  28
<212>  PRT
<213>  Unknown

<220>
<223>  Carboxy-terminal moiety

<400>  185

Asn Leu Val Pro Met Val Ala Thr Val His His Ala Ala Asn Leu Val 
1               5                   10                  15      


Pro Met Val Ala Thr Val Arg Arg Asn Leu Val Pro 
            20                  25              


<210>  186
<211>  35
<212>  PRT
<213>  Unknown

<220>
<223>  Carboxy-terminal moiety

<400>  186

Asn Leu Val Pro Met Val Ala Thr Val His His Ala Ala Asn Leu Val 
1               5                   10                  15      


Pro Met Val Ala Thr Val His His Ala Ala Asn Leu Val Pro Met Val 
            20                  25                  30          


Ala Thr Val 
        35  


<210>  187
<211>  30
<212>  PRT
<213>  Unknown

<220>
<223>  Carboxy-terminal moiety

<400>  187

Asn Leu Val Pro Met Val Ala Thr Val His His Ala Ala Asn Leu Val 
1               5                   10                  15      


Pro Met Val Ala Thr Val His His Ala Ala Asn Leu Val Pro 
            20                  25                  30  


<210>  188
<211>  12
<212>  PRT
<213>  Unknown

<220>
<223>  proteinaceous linker

<400>  188

Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser 
1               5                   10          


<210>  189
<211>  14
<212>  PRT
<213>  Unknown

<220>
<223>  proteinaceous linker

<400>  189

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Glu Phe 
1               5                   10                  


<210>  190
<211>  14
<212>  PRT
<213>  Unknown

<220>
<223>  proteinaceous linker

<400>  190

Gly Ser Thr Ser Gly Ser Gly Lys Ser Ser Glu Gly Lys Gly 
1               5                   10                  


<210>  191
<211>  18
<212>  PRT
<213>  Unknown

<220>
<223>  proteinaceous linker

<400>  191

Gly Ser Thr Ser Gly Ser Gly Lys Ser Ser Glu Gly Ser Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  192
<211>  18
<212>  PRT
<213>  Unknown

<220>
<223>  proteinaceous linker

<400>  192

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  193
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  proteinaceous linker

<400>  193

Ser Arg Ser Ser Gly 
1               5   


<210>  194
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  proteinaceous linker

<400>  194

Ser Gly Ser Ser Cys 
1               5   


<210>  195
<211>  28
<212>  PRT
<213>  Unknown

<220>
<223>  proteinaceous linker

<400>  195

Ala Met Gly Arg Ser Gly Gly Gly Cys Ala Gly Asn Arg Val Gly Ser 
1               5                   10                  15      


Ser Leu Ser Cys Gly Gly Leu Asn Leu Gln Ala Met 
            20                  25              


<210>  196
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv linker

<400>  196

Gly Gly Gly Ser 
1               


<210>  197
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv linker

<400>  197

Gly Gly Gly Gly Ser Gly Gly Gly 
1               5               


<210>  198
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv linker

<400>  198

Gly Gly Ser Gly Gly Gly Gly 
1               5           


<210>  199
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv linker

<400>  199

Gly Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Ser 
        


<210>  200
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv linker

<400>  200

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Ser Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  201
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv linker


<220>
<221>  MISC_FEATURE
<222>  (3)..(4)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (9)..(10)
<223>  may be absent

<400>  201

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10  


<210>  202
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv linker


<220>
<221>  MISC_FEATURE
<222>  (6)..(10)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (21)..(25)
<223>  may be absent

<400>  202

Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Ser Gly Gly Ser Gly Ser Gly Gly Ser 
            20                  25  


<210>  203
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv linker


<220>
<221>  MISC_FEATURE
<222>  (6)..(10)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (21)..(25)
<223>  may be absent

<400>  203

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  204
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv linker


<220>
<221>  MISC_FEATURE
<222>  (5)..(8)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (9)..(12)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (13)..(16)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (17)..(20)
<223>  may be absent

<400>  204

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  205
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  205

Lys Asp Glu Leu 
1               


<210>  206
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  206

His Asp Glu Phe 
1               


<210>  207
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  207

His Asp Glu Leu 
1               


<210>  208
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  208

Arg Asp Glu Phe 
1               


<210>  209
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  209

Arg Asp Glu Leu 
1               


<210>  210
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  210

Trp Asp Glu Leu 
1               


<210>  211
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  211

Tyr Asp Glu Leu 
1               


<210>  212
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  212

His Glu Glu Phe 
1               


<210>  213
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  213

His Glu Glu Leu 
1               


<210>  214
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  214

Lys Glu Glu Leu 
1               


<210>  215
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  215

Arg Glu Glu Leu 
1               


<210>  216
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  216

Lys Ala Glu Leu 
1               


<210>  217
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  217

Lys Cys Glu Leu 
1               


<210>  218
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  218

Lys Phe Glu Leu 
1               


<210>  219
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  219

Lys Gly Glu Leu 
1               


<210>  220
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  220

Lys His Glu Leu 
1               


<210>  221
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  221

Lys Leu Glu Leu 
1               


<210>  222
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  222

Lys Asn Glu Leu 
1               


<210>  223
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  223

Lys Gln Glu Leu 
1               


<210>  224
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  224

Lys Arg Glu Leu 
1               


<210>  225
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  225

Lys Ser Glu Leu 
1               


<210>  226
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  226

Lys Val Glu Leu 
1               


<210>  227
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  227

Lys Trp Glu Leu 
1               


<210>  228
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  228

Lys Tyr Glu Leu 
1               


<210>  229
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  229

Lys Glu Asp Leu 
1               


<210>  230
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  230

Lys Ile Glu Leu 
1               


<210>  231
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  231

Asp Lys Glu Leu 
1               


<210>  232
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  232

Phe Asp Glu Leu 
1               


<210>  233
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  233

Lys Asp Glu Phe 
1               


<210>  234
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  234

Lys Lys Glu Leu 
1               


<210>  235
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  235

His Ala Asp Leu 
1               


<210>  236
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  236

His Ala Glu Leu 
1               


<210>  237
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  237

His Ile Glu Leu 
1               


<210>  238
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  238

His Asn Glu Leu 
1               


<210>  239
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  239

His Thr Glu Leu 
1               


<210>  240
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  240

Lys Thr Glu Leu 
1               


<210>  241
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  241

His Val Glu Leu 
1               


<210>  242
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  242

Asn Asp Glu Leu 
1               


<210>  243
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  243

Gln Asp Glu Leu 
1               


<210>  244
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  244

Arg Glu Asp Leu 
1               


<210>  245
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  245

Arg Asn Glu Leu 
1               


<210>  246
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  246

Arg Thr Asp Leu 
1               


<210>  247
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  247

Arg Thr Glu Leu 
1               


<210>  248
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  248

Ser Asp Glu Leu 
1               


<210>  249
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  249

Thr Asp Glu Leu 
1               


<210>  250
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  250

Ser Lys Glu Leu 
1               


<210>  251
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  251

Ser Thr Glu Leu 
1               


<210>  252
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  endoplasmic reticulum retention/retrieval signal motif

<400>  252

Glu Asp Glu Leu 
1               


<210>  253

<400>  253
000

<210>  254

<400>  254
000

<210>  255

<400>  255
000

<210>  256

<400>  256
000

<210>  257

<400>  257
000

<210>  258

<400>  258
000

<210>  259
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Binding Molecule 114962

<400>  259

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu 
            260                 265                 270         


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
        275                 280                 285             


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser Trp Ile His Trp 
    290                 295                 300                 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Ser 
305                 310                 315                 320 


Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
                325                 330                 335     


Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
            340                 345                 350         


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg His 
        355                 360                 365             


Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    370                 375                 380                 


Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
385                 390                 395                 400 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
                405                 410                 415     


Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
            420                 425                 430         


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly 
        435                 440                 445             


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    450                 455                 460                 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
465                 470                 475                 480 


Gln Tyr Leu Tyr His Pro Ala Thr Phe Gly Gln Gly Thr Lys Val Glu 
                485                 490                 495     


Ile Lys 
        


<210>  260
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Binding Molecule 114963

<400>  260

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile Tyr Ala Ala Ser 
305                 310                 315                 320 


Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu 
    370                 375                 380                 


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
385                 390                 395                 400 


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asp Val His Trp 
                405                 410                 415     


Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met Gly Trp Leu His 
            420                 425                 430         


Ala Asp Thr Gly Ile Thr Lys Phe Ser Gln Lys Phe Gln Gly Arg Val 
        435                 440                 445             


Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser 
    450                 455                 460                 


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Arg 
465                 470                 475                 480 


Ile Gln Leu Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                485                 490                 495     


Ser Ser 
        


<210>  261
<211>  518
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Binding Molecule 114964

<400>  261

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu 
            260                 265                 270         


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
        275                 280                 285             


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser Trp Ile His Trp 
    290                 295                 300                 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Ser 
305                 310                 315                 320 


Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
                325                 330                 335     


Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
            340                 345                 350         


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg His 
        355                 360                 365             


Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    370                 375                 380                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
                405                 410                 415     


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
            420                 425                 430         


Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln 
        435                 440                 445             


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe 
    450                 455                 460                 


Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
465                 470                 475                 480 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
                485                 490                 495     


Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala Thr Phe Gly Gln Gly 
            500                 505                 510         


Thr Lys Val Glu Ile Lys 
        515             


<210>  262
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  MISC_FEATURE
<222>  (2)..(6)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (8)..(14)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (9)..(14)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (15)..(21)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (22)..(28)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (23)..(27)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (29)..(34)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (30)..(33)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (35)..(42)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (36)..(41)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (43)..(49)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (44)..(48)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (50)..(56)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (51)..(55)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (57)..(63)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (58)..(62)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (64)..(70)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (65)..(69)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (71)..(77)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (72)..(76)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (78)..(84)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (79)..(83)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (85)..(91)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (86)..(90)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (92)..(98)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (93)..(97)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (99)..(105)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (100)..(104)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (106)..(112)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (107)..(111)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (113)..(119)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (114)..(118)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (120)..(126)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (121)..(125)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (127)..(133)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (128)..(132)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (134)..(140)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (135)..(139)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (141)..(147)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (142)..(146)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (148)..(154)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (149)..(153)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (155)..(161)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (156)..(160)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (162)..(168)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (163)..(167)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (169)..(175)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (170)..(174)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (176)..(182)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (177)..(181)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (183)..(189)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (184)..(188)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (190)..(196)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (191)..(195)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (197)..(203)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (198)..(202)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (204)..(210)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (205)..(209)
<223>  may be absent

<400>  262

Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly 
    50                  55                  60                  


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly 
                85                  90                  95      


Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly 
                165                 170                 175     


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly 
            180                 185                 190         


Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly 
        195                 200                 205             


Gly Ser 
    210 


<210>  263
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  MISC_FEATURE
<222>  (2)..(6)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (8)..(14)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (9)..(14)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (15)..(21)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (22)..(28)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (23)..(27)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (29)..(34)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (30)..(33)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (35)..(42)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (36)..(41)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (43)..(49)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (44)..(48)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (50)..(56)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (51)..(55)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (57)..(63)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (58)..(62)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (64)..(70)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (65)..(69)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (71)..(77)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (72)..(76)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (78)..(84)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (79)..(83)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (85)..(91)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (86)..(90)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (92)..(98)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (93)..(97)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (99)..(105)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (100)..(104)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (106)..(112)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (107)..(111)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (113)..(119)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (114)..(118)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (120)..(126)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (121)..(125)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (127)..(133)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (128)..(132)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (134)..(140)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (135)..(139)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (141)..(147)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (142)..(146)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (148)..(154)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (149)..(153)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (155)..(161)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (156)..(160)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (162)..(168)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (163)..(167)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (169)..(175)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (170)..(174)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (176)..(182)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (177)..(181)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (183)..(189)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (184)..(188)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (190)..(196)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (191)..(195)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (197)..(203)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (198)..(202)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (204)..(210)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (205)..(209)
<223>  may be absent

<400>  263

Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser 
1               5                   10                  15      


Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser 
            20                  25                  30          


Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser 
        35                  40                  45              


Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser 
    50                  55                  60                  


Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser 
65                  70                  75                  80  


Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser 
                85                  90                  95      


Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly 
            100                 105                 110         


Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser 
        115                 120                 125             


Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser 
    130                 135                 140                 


Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser 
145                 150                 155                 160 


Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser 
                165                 170                 175     


Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser 
            180                 185                 190         


Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser 
        195                 200                 205             


Ser Gly 
    210 


<210>  264
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  MISC_FEATURE
<222>  (2)..(30)
<223>  each residue individually may be absent or present

<400>  264

Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
            20                  25                  30  


<210>  265
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavable spacer

<400>  265

His His Ala Ala 
1               


<210>  266
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  MISC_FEATURE
<222>  (6)..(10)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (21)..(25)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (26)..(30)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (31)..(35)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (36)..(40)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (41)..(45)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (46)..(50)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (51)..(55)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (56)..(60)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (61)..(65)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (66)..(70)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (71)..(75)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (76)..(80)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (81)..(85)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (86)..(90)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (91)..(95)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (96)..(100)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (106)..(110)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (111)..(115)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (116)..(120)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (121)..(125)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (126)..(130)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (131)..(135)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (136)..(140)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (141)..(145)
<223>  may be absent

<220>
<221>  MISC_FEATURE
<222>  (146)..(150)
<223>  may be absent

<400>  266

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser 
145                 150 


<210>  267

<400>  267
000

<210>  268

<400>  268
000

<210>  269

<400>  269
000

<210>  270

<400>  270
000

<210>  271

<400>  271
000

<210>  272

<400>  272
000

<210>  273

<400>  273
000

<210>  274

<400>  274
000

<210>  275

<400>  275
000

<210>  276

<400>  276
000

<210>  277

<400>  277
000

<210>  278

<400>  278
000

<210>  279

<400>  279
000

<210>  280

<400>  280
000

<210>  281

<400>  281
000

<210>  282

<400>  282
000

<210>  283

<400>  283
000

<210>  284

<400>  284
000

<210>  285

<400>  285
000

<210>  286

<400>  286
000

<210>  287

<400>  287
000

<210>  288

<400>  288
000

<210>  289

<400>  289
000

<210>  290

<400>  290
000

<210>  291

<400>  291
000

<210>  292

<400>  292
000

<210>  293

<400>  293
000

<210>  294

<400>  294
000

<210>  295

<400>  295
000

<210>  296

<400>  296
000

<210>  297

<400>  297
000

<210>  298

<400>  298
000

<210>  299

<400>  299
000

<210>  300
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8+ T-cell epitope

<400>  300

Tyr Ser Glu His Pro Thr Phe Thr Ser Gln Tyr 
1               5                   10      


<210>  301
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8+ T-cell epitope

<400>  301

Lys Leu Gly Gly Ala Leu Gln Ala Lys 
1               5                   


<210>  302
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8+ T-cell epitope

<400>  302

Gln Tyr Asp Pro Val Ala Ala Leu Phe 
1               5                   


<210>  303
<211>  516
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding molecule

<400>  303

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu 
            260                 265                 270         


Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile 
        275                 280                 285             


Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp 
    290                 295                 300                 


Val Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn 
305                 310                 315                 320 


Pro Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala 
                325                 330                 335     


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg 
            340                 345                 350         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr 
        355                 360                 365             


Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
    370                 375                 380                 


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
385                 390                 395                 400 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                405                 410                 415     


Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln 
            420                 425                 430         


Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu Thr Ser Asn Leu 
        435                 440                 445             


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
    450                 455                 460                 


Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr 
465                 470                 475                 480 


Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr 
                485                 490                 495     


Lys Leu Glu Leu Lys His His Ala Ala Tyr Ser Glu His Pro Thr Phe 
            500                 505                 510         


Thr Ser Gln Tyr 
        515     


<210>  304
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding molecule

<400>  304

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu 
            260                 265                 270         


Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile 
        275                 280                 285             


Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp 
    290                 295                 300                 


Val Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn 
305                 310                 315                 320 


Pro Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala 
                325                 330                 335     


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg 
            340                 345                 350         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr 
        355                 360                 365             


Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
    370                 375                 380                 


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
385                 390                 395                 400 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                405                 410                 415     


Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln 
            420                 425                 430         


Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu Thr Ser Asn Leu 
        435                 440                 445             


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
    450                 455                 460                 


Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr 
465                 470                 475                 480 


Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr 
                485                 490                 495     


Lys Leu Glu Leu Lys His His Ala Ala Val Thr Glu His Asp Thr Leu 
            500                 505                 510         


Leu Tyr 
        


<210>  305
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding molecule

<400>  305

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu 
            260                 265                 270         


Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile 
        275                 280                 285             


Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp 
    290                 295                 300                 


Val Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn 
305                 310                 315                 320 


Pro Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala 
                325                 330                 335     


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg 
            340                 345                 350         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr 
        355                 360                 365             


Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
    370                 375                 380                 


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
385                 390                 395                 400 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                405                 410                 415     


Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln 
            420                 425                 430         


Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu Thr Ser Asn Leu 
        435                 440                 445             


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
    450                 455                 460                 


Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr 
465                 470                 475                 480 


Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr 
                485                 490                 495     


Lys Leu Glu Leu Lys His His Ala Ala Lys Leu Gly Gly Ala Leu Gln 
            500                 505                 510         


Ala Lys 
        


<210>  306
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding molecule

<400>  306

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu 
            260                 265                 270         


Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile 
        275                 280                 285             


Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp 
    290                 295                 300                 


Val Lys Gln Arg His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn 
305                 310                 315                 320 


Pro Asn Asn Gly Gly Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala 
                325                 330                 335     


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg 
            340                 345                 350         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr 
        355                 360                 365             


Tyr Tyr Gly Ser Arg Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
    370                 375                 380                 


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
385                 390                 395                 400 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                405                 410                 415     


Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln 
            420                 425                 430         


Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr Leu Thr Ser Asn Leu 
        435                 440                 445             


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
    450                 455                 460                 


Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr 
465                 470                 475                 480 


Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr 
                485                 490                 495     


Lys Leu Glu Leu Lys His His Ala Ala Gln Tyr Asp Pro Val Ala Ala 
            500                 505                 510         


Leu Phe 
        


<210>  307
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding molecule

<400>  307

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Tyr Ser Glu His 
                245                 250                 255     


Pro Thr Phe Thr Ser Gln Tyr Glu Phe Pro Lys Pro Ser Thr Pro Pro 
            260                 265                 270         


Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu Gln Gln Ser Gly Pro 
        275                 280                 285             


Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser 
    290                 295                 300                 


Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp Val Lys Gln Arg His 
305                 310                 315                 320 


Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn Pro Asn Asn Gly Gly 
                325                 330                 335     


Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp 
            340                 345                 350         


Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu 
        355                 360                 365             


Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr Tyr Tyr Gly Ser Arg 
    370                 375                 380                 


Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
                405                 410                 415     


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser 
            420                 425                 430         


Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser 
        435                 440                 445             


Pro Lys Pro Trp Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Val Pro 
    450                 455                 460                 


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
465                 470                 475                 480 


Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
                485                 490                 495     


Ser Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            500                 505                 510         


<210>  308
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding molecule

<400>  308

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Val Thr Glu His 
                245                 250                 255     


Asp Thr Leu Leu Tyr Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser 
            260                 265                 270         


Ser Gly Gly Ala Pro Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
        275                 280                 285             


Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr 
    290                 295                 300                 


Thr Phe Thr Glu Tyr Thr Met His Trp Val Lys Gln Arg His Gly Lys 
305                 310                 315                 320 


Ser Leu Glu Trp Ile Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr Trp 
                325                 330                 335     


Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser 
            340                 345                 350         


Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser 
        355                 360                 365             


Ala Val Tyr Phe Cys Ala Arg Pro Tyr Tyr Tyr Gly Ser Arg Glu Asp 
    370                 375                 380                 


Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
                405                 410                 415     


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser 
            420                 425                 430         


Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys 
        435                 440                 445             


Pro Trp Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
    450                 455                 460                 


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser 
465                 470                 475                 480 


Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser 
                485                 490                 495     


Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            500                 505                 510 


<210>  309
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding molecule

<400>  309

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Lys Leu Gly Gly 
                245                 250                 255     


Ala Leu Gln Ala Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser 
            260                 265                 270         


Ser Gly Gly Ala Pro Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
        275                 280                 285             


Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr 
    290                 295                 300                 


Thr Phe Thr Glu Tyr Thr Met His Trp Val Lys Gln Arg His Gly Lys 
305                 310                 315                 320 


Ser Leu Glu Trp Ile Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr Trp 
                325                 330                 335     


Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser 
            340                 345                 350         


Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser 
        355                 360                 365             


Ala Val Tyr Phe Cys Ala Arg Pro Tyr Tyr Tyr Gly Ser Arg Glu Asp 
    370                 375                 380                 


Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
                405                 410                 415     


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser 
            420                 425                 430         


Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys 
        435                 440                 445             


Pro Trp Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
    450                 455                 460                 


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser 
465                 470                 475                 480 


Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser 
                485                 490                 495     


Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            500                 505                 510 


<210>  310
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding molecule

<400>  310

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Gln Tyr Asp Pro 
                245                 250                 255     


Val Ala Ala Leu Phe Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser 
            260                 265                 270         


Ser Gly Gly Ala Pro Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
        275                 280                 285             


Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr 
    290                 295                 300                 


Thr Phe Thr Glu Tyr Thr Met His Trp Val Lys Gln Arg His Gly Lys 
305                 310                 315                 320 


Ser Leu Glu Trp Ile Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr Trp 
                325                 330                 335     


Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser 
            340                 345                 350         


Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser 
        355                 360                 365             


Ala Val Tyr Phe Cys Ala Arg Pro Tyr Tyr Tyr Gly Ser Arg Glu Asp 
    370                 375                 380                 


Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
                405                 410                 415     


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser 
            420                 425                 430         


Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys 
        435                 440                 445             


Pro Trp Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
    450                 455                 460                 


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser 
465                 470                 475                 480 


Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser 
                485                 490                 495     


Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            500                 505                 510 


<210>  311
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding molecule

<400>  311

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Tyr Ser Glu His 
                245                 250                 255     


Pro Thr Phe Thr Ser Gln Tyr Glu Phe Pro Lys Pro Ser Thr Pro Pro 
            260                 265                 270         


Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu Gln Gln Ser Gly Pro 
        275                 280                 285             


Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser 
    290                 295                 300                 


Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp Val Lys Gln Arg His 
305                 310                 315                 320 


Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn Pro Asn Asn Gly Gly 
                325                 330                 335     


Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp 
            340                 345                 350         


Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu 
        355                 360                 365             


Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr Tyr Tyr Gly Ser Arg 
    370                 375                 380                 


Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
                405                 410                 415     


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser 
            420                 425                 430         


Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser 
        435                 440                 445             


Pro Lys Pro Trp Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Val Pro 
    450                 455                 460                 


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
465                 470                 475                 480 


Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
                485                 490                 495     


Ser Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            500                 505                 510         


His His Ala Ala Asn Leu Val Pro Met Val Ala Thr Val Arg Arg Val 
        515                 520                 525             


Thr Glu His Asp Thr Leu Leu Tyr 
    530                 535     


<210>  312
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding molecule

<400>  312

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Tyr Ser Glu His 
                245                 250                 255     


Pro Thr Phe Thr Ser Gln Tyr Glu Phe Pro Lys Pro Ser Thr Pro Pro 
            260                 265                 270         


Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu Gln Gln Ser Gly Pro 
        275                 280                 285             


Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser 
    290                 295                 300                 


Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp Val Lys Gln Arg His 
305                 310                 315                 320 


Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn Pro Asn Asn Gly Gly 
                325                 330                 335     


Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp 
            340                 345                 350         


Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu 
        355                 360                 365             


Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr Tyr Tyr Gly Ser Arg 
    370                 375                 380                 


Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
                405                 410                 415     


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser 
            420                 425                 430         


Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser 
        435                 440                 445             


Pro Lys Pro Trp Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Val Pro 
    450                 455                 460                 


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
465                 470                 475                 480 


Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
                485                 490                 495     


Ser Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            500                 505                 510         


His His Ala Ala Lys Leu Gly Gly Ala Leu Gln Ala Lys Arg Arg Gln 
        515                 520                 525             


Tyr Asp Pro Val Ala Ala Leu Phe 
    530                 535     


<210>  313
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 binding molecule

<400>  313

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Tyr Ser Glu His 
                245                 250                 255     


Pro Thr Phe Thr Ser Gln Tyr Glu Phe Pro Lys Pro Ser Thr Pro Pro 
            260                 265                 270         


Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu Gln Gln Ser Gly Pro 
        275                 280                 285             


Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser 
    290                 295                 300                 


Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp Val Lys Gln Arg His 
305                 310                 315                 320 


Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn Pro Asn Asn Gly Gly 
                325                 330                 335     


Thr Trp Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp 
            340                 345                 350         


Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu 
        355                 360                 365             


Asp Ser Ala Val Tyr Phe Cys Ala Arg Pro Tyr Tyr Tyr Gly Ser Arg 
    370                 375                 380                 


Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
                405                 410                 415     


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser 
            420                 425                 430         


Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser 
        435                 440                 445             


Pro Lys Pro Trp Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly Val Pro 
    450                 455                 460                 


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
465                 470                 475                 480 


Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
                485                 490                 495     


Ser Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            500                 505                 510         


His His Ala Ala Gln Tyr Asp Pro Val Ala Ala Leu Phe Arg Arg Lys 
        515                 520                 525             


Leu Gly Gly Ala Leu Gln Ala Lys 
    530                 535     


<210>  314
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8+ T-cell epitope

<400>  314

Ala Tyr Ala Gln Lys Ile Phe Lys Ile 
1               5                   


<210>  315
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8+ T-cell epitope

<400>  315

Thr Val Arg Ser His Cys Val Ser Lys 
1               5                   


<210>  316
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8+ T-cell epitope

<400>  316

Thr Leu Leu Asn Cys Ala Val Thr Lys 
1               5                   


