                         SEQUENCE LISTING

<110>  Wisconsin Alumni Research Foundation
       Alam, Tausif
       Sollinger, Hans
 
<120>  INSULIN GENE THERAPY TO TREAT DIABETES

<130>  960296.04288

<150>  63/161,495
<151>  2021-03-16

<150>  63/165,310
<151>  2021-03-24

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  5925
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - C36-AAV8 construct

<400>  1
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggg gttcctgcta      120

ttcccatatg attctagagc tcgtcgaccc gcccccttca ccaagatctt tttgatggca      180

gagttcagtt taccgggtca cattgtacct gggaagattc aaggatttat ggaaaaagtc      240

aacaacagga gtcagagcag ccggaaaagc atggactctg tacttaggac tgcgctttga      300

gcaatggcac agcaagcttt aaccctgttt gcagtcagca cacaaactgt ggttcaaagc      360

tccactttat ctcttcttgt ggaattcaga tatcagatca gtttaaacct tgcggccgcc      420

agttctcacg tggtggccac gtgcttgggc actctagtgc tcaaatggga gacaaagaga      480

ttaagctctt atgtaaaatt tgctgtttta cataacttta atgaatggac aaagtcttgt      540

gcatgggggt gggggtgggg ttagagggga acagctccag atggcaaaca tacgcaaggg      600

atttagtcaa acaacttttt ggcaaagatg gtatgatttt gtaatggggt aggaaccaat      660

gaaatgcgag gtaagtatgg ttaataatct acagttattg gttaaagaag tatattagag      720

cgagtctttc tgcacacaga tcaccttcct atcaacccca ctagcctctg gcaaaggtac      780

cagcgcagag gcttggggca gccgagcggc agccaggccc cggcccgggc ctcggttcca      840

gaagggagag gagcccgcca aggcgcgcaa gagagcgggc tgcctcgcag tccgagccgg      900

agagggagcg cgagccgcgc cggccccgga cggcctccga aaccatggct ctgtggatga      960

gattcctgcc tctgctggcc ctgctggtgc tgtgggaacc taagcctgcc caggccttcg     1020

tgaagcagca cctgtgtgga ccccacctgg tggaagccct gtacctcgtg tgtggcgaga     1080

gaggcttctt ctacacccct aggaccaaga gagaggtgga agatccccag gtgccccagc     1140

tggaactggg cggaggacct gaagctggcg acctgcagac actggccctg gaagtggcca     1200

gacagaaaag gggcatcgtg gaccagtgct gcaccagcat ctgcagcctg tatcagctgg     1260

aaaactactg caactgaacg cagcctgcag gcagcgtcga gtaacatcac atttaaaagc     1320

atctcaggta actatatttt gaatttttta aaaaagtaac tataatagtt attattaaaa     1380

tagcaaagat tgaccatttc caagagccat atagaccagc accgaccact attctaaact     1440

atttatgtat gtaaatatta gcttttaaaa ttctcaaaat agttgctgag ttgggaacca     1500

ctattatttc tatcgattca gcagccgtaa gtctaggaca ggcttaaatt gttttcactg     1560

gtgtaaattg cagaaagatg atctaagtaa tttggcattt attttaatag gtttgaaaaa     1620

cacatgccat tttacaaata agacttatat ttgtcctttt gtttttcagc ctaccatgag     1680

aataagagaa agaaaatgaa gatcaaaagc ttattcatct gtttttcttt ttcgttggtg     1740

taaagccaac accctgtcta aaaaacataa atttctttaa tcattttgcc tcttttctct     1800

gtgcttcaat taataaaaaa tggaaagaat ctaatagagt ggtacagcac tgttattttt     1860

caaagatgtg ttgctatcct gaaaattctg taggttctgt ggaagttcca gtgttctctc     1920

ttattccact tcggtagagg atttctagtt tcttgtgggc taattaaata aatcattaat     1980

actcttctaa gttatggatt ataaacattc aaaataatat tttgacatta tgataattct     2040

gaataaaaga acaaaaacca tggtataggt aaggaatata aaacatggct tttaccttag     2100

aaaaaacaat tctaaaattc atatgattct agaactagtg gggtaccgaa ttcagatcga     2160

gcatggctac gtagataagt agcatggcgg gttaatcatt aactacaagg aacccctagt     2220

gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa     2280

ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag cgcgcagctg     2340

gcgtaatagc gaagaggccc gcaccgatcg cccttcccaa cagttgcgca gcctgaatgg     2400

cgaatggcga ttccgttgca atggctggcg gtaatattgt tctggatatt accagcaagg     2460

ccgatagttt gagttcttct actcaggcaa gtgatgttat tactaatcaa agaagtattg     2520

cgacaacggt taatttgcgt gatggacaga ctcttttact cggtggcctc actgattata     2580

aaaacacttc tcaggattct ggcgtaccgt tcctgtctaa aatcccttta atcggcctcc     2640

tgtttagctc ccgctctgat tctaacgagg aaagcacgtt atacgtgctc gtcaaagcaa     2700

ccatagtacg cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc     2760

gtgaccgcta cacttgccag cgccctagcg cccgctcctt tcgctttctt cccttccttt     2820

ctcgccacgt tcgccggctt tccccgtcaa gctctaaatc gggggctccc tttagggttc     2880

cgatttagtg ctttacggca cctcgacccc aaaaaacttg attagggtga tggttcacgt     2940

agtgggccat cgccctgata gacggttttt cgccctttga cgttggagtc cacgttcttt     3000

aatagtggac tcttgttcca aactggaaca acactcaacc ctatctcggt ctattctttt     3060

gatttataag ggattttgcc gatttcggcc tattggttaa aaaatgagct gatttaacaa     3120

aaatttaacg cgaattttaa caaaatatta acgcttacaa tttaaatatt tgcttataca     3180

atcttcctgt ttttggggct tttctgatta tcaaccgggg tacatatgat tgacatgcta     3240

gttttacgat taccgttcat cgattctctt gtttgctcca gactctcagg caatgacctg     3300

atagcctttg tagagacctc tcaaaaatag ctaccctctc cggcatgaat ttatcagcta     3360

gaacggttga atatcatatt gatggtgatt tgactgtctc cggcctttct cacccgtttg     3420

aatctttacc tacacattac tcaggcattg catttaaaat atatgagggt tctaaaaatt     3480

tttatccttg cgttgaaata aaggcttctc ccgcaaaagt attacagggt cataatgttt     3540

ttggtacaac cgatttagct ttatgctctg aggctttatt gcttaatttt gctaattctt     3600

tgccttgcct gtatgattta ttggatgttg gaatcgcctg atgcggtatt ttctccttac     3660

gcatctgtgc ggtatttcac accgcatatg gtgcactctc agtacaatct gctctgatgc     3720

cgcatagtta agccagcccc gacacccgcc aacacccgct gacgcgccct gacgggcttg     3780

tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct gcatgtgtca     3840

gaggttttca ccgtcatcac cgaaacgcgc gagacgaaag ggcctcgtga tacgcctatt     3900

tttataggtt aatgtcatga taataatggt ttcttagacg tcaggtggca cttttcgggg     3960

aaatgtgcgc ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct     4020

catgagacaa taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat     4080

tcaacatttc cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc     4140

tcacccagaa acgctggtga aagtaaaaga tgctgaagat cagttgggtg cacgagtggg     4200

ttacatcgaa ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg     4260

ttttccaatg atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtattga     4320

cgccgggcaa gagcaactcg gtcgccgcat acactattct cagaatgact tggttgagta     4380

ctcaccagtc acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc     4440

tgccataacc atgagtgata acactgcggc caacttactt ctgacaacga tcggaggacc     4500

gaaggagcta accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg     4560

ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgtagc     4620

aatggcaaca acgttgcgca aactattaac tggcgaacta cttactctag cttcccggca     4680

acaattaata gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct     4740

tccggctggc tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat     4800

cattgcagca ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg     4860

gagtcaggca actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat     4920

taagcattgg taactgtcag accaagttta ctcatatata ctttagattg atttaaaact     4980

tcatttttaa tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat     5040

cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc     5100

ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct     5160

accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg     5220

cttcagcaga gcgcagatac caaatactgt tcttctagtg tagccgtagt taggccacca     5280

cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc     5340

tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga     5400

taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac     5460

gacctacacc gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga     5520

agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag     5580

ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg     5640

acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag     5700

caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc     5760

tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc     5820

tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc     5880

aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatg                     5925


<210>  2
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - mutant 5' inverted terminal repeat (ITR)

<400>  2
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtgg                  109


<210>  3
<211>  251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - Alfa-fetoprotein enhancer

<400>  3
aagatctttt tgatggcaga gttcagttta ccgggtcaca ttgtacctgg gaagattcaa       60

ggatttatgg aaaaagtcaa caacaggagt cagagcagcc ggaaaagcat ggactctgta      120

cttaggactg cgctttgagc aatggcacag caagctttaa ccctgtttgc agtcagcaca      180

caaactgtgg ttcaaagctc cactttatct cttcttgtgg aattcagata tcagatcagt      240

ttaaaccttg c                                                           251


<210>  4
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - glucose inducible regulatory element (GIRE) from S14

<400>  4
cacgtggtgg ccacgtg                                                      17


<210>  5
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - Rat albumin promoter

<400>  5
ctagtgctca aatgggagac aaagagatta agctcttatg taaaatttgc tgttttacat       60

aactttaatg aatggacaaa gtcttgtgca tgggggtggg ggtggggtta gaggggaaca      120

gctccagatg gcaaacatac gcaagggatt tagtcaaaca actttttggc aaagatggta      180

tgattttgta atggggtagg aaccaatgaa atgcgaggta agtatggtta ataatctaca      240

gttattggtt aaagaagtat attagagcga gtctttctgc acacagatca ccttcctatc      300

aaccccacta gcctctggca aaggtac                                          327


<210>  6
<211>  164
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - Vascular endothelial growth factor (VEGF) 
       translational enhancer

<400>  6
cagcgcagag gcttggggca gccgagcggc agccaggccc cggcccgggc ctcggttcca       60

gaagggagag gagcccgcca aggcgcgcaa gagagcgggc tgcctcgcag tccgagccgg      120

agagggagcg cgagccgcgc cggccccgga cggcctccga aacc                       164


<210>  7
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - Polynucleotide encoding rat insulin 1, furin 
       cleavable, codon optimized

<400>  7
atggctctgt ggatgagatt cctgcctctg ctggccctgc tggtgctgtg ggaacctaag       60

cctgcccagg ccttcgtgaa gcagcacctg tgtggacccc acctggtgga agccctgtac      120

ctcgtgtgtg gcgagagagg cttcttctac acccctagga ccaagagaga ggtggaagat      180

ccccaggtgc cccagctgga actgggcgga ggacctgaag ctggcgacct gcagacactg      240

gccctggaag tggccagaca gaaaaggggc atcgtggacc agtgctgcac cagcatctgc      300

agcctgtatc agctggaaaa ctactgcaac tga                                   333


<210>  8
<211>  842
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - Albumin 3' UTR

<400>  8
acgcagcctg caggcagcgt cgagtaacat cacatttaaa agcatctcag gtaactatat       60

tttgaatttt ttaaaaaagt aactataata gttattatta aaatagcaaa gattgaccat      120

ttccaagagc catatagacc agcaccgacc actattctaa actatttatg tatgtaaata      180

ttagctttta aaattctcaa aatagttgct gagttgggaa ccactattat ttctatcgat      240

tcagcagccg taagtctagg acaggcttaa attgttttca ctggtgtaaa ttgcagaaag      300

atgatctaag taatttggca tttattttaa taggtttgaa aaacacatgc cattttacaa      360

ataagactta tatttgtcct tttgtttttc agcctaccat gagaataaga gaaagaaaat      420

gaagatcaaa agcttattca tctgtttttc tttttcgttg gtgtaaagcc aacaccctgt      480

ctaaaaaaca taaatttctt taatcatttt gcctcttttc tctgtgcttc aattaataaa      540

aaatggaaag aatctaatag agtggtacag cactgttatt tttcaaagat gtgttgctat      600

cctgaaaatt ctgtaggttc tgtggaagtt ccagtgttct ctcttattcc acttcggtag      660

aggatttcta gtttcttgtg ggctaattaa ataaatcatt aatactcttc taagttatgg      720

attataaaca ttcaaaataa tattttgaca ttatgataat tctgaataaa agaacaaaaa      780

ccatggtata ggtaaggaat ataaaacatg gcttttacct tagaaaaaac aattctaaaa      840

tt                                                                     842


<210>  9
<211>  136
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - 3' inverted terminal repeat (ITR)

<400>  9
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag ctggcg                                                      136


<210>  10
<211>  568
<212>  DNA
<213>  Rattus norvegicus

<400>  10
aaccctaagt gaccagctac aatcatagac catcagcaag caggtatgta ctctcctggg       60

tgagcccggt tcccccagcc aaaactctag ggactttagg aaggatgtgg gttcctctct      120

tacatggacc ttttcctagc ctcaaccctg cctatcttcc aggtcattgt tccaacatgg      180

ccctgtggat gcgcttcctg cccctgctgg ccctgctcgt cctctgggag cccaagcctg      240

cccaggcttt tgtcaaacag cacctttgtg gtcctcacct ggtggaggct ctgtacctgg      300

tgtgtgggga acgtggtttc ttctacacac ccaagtcccg tcgtgaagtg gaggacccgc      360

aagtgccaca actggagctg ggtggaggcc cggaggccgg ggatcttcag accttggcac      420

tggaggttgc ccggcagaag cgtggcattg tggatcagtg ctgcaccagc atctgctccc      480

tctaccaact ggagaactac tgcaactgag tccaccactc cccgcccacc cctctgcaat      540

gaataaagcc tttgaatgag caccaaaa                                         568


<210>  11
<211>  961
<212>  DNA
<213>  Felis catus

<400>  11
gccggcgggg cccagcagcc agcagccccc ccccccggga ccacctgcac cctgacacgg       60

acggcaagca ggtctgtccc cacgggctcc ccgtcagctg agtccagggt gtcacacggg      120

gccccgggcc cgggctctcg agccggcggg aggacgaggg ctcccagcac agagcatctg      180

gggggcgagc gcagggcggg ggtcctgggt gcggcgcgtg cccctcgccg gcctcaaccc      240

tgcccgtccc ccaggtcgct gtcccccgcc atggccccgt ggacgcgcct cctgcccctg      300

ctggcgttgc tgtccctctg gatccctgcc ccgacccgag ccttcgtcaa ccagcacctg      360

tgcggctccc acctggtgga ggcgctgtac ctggtgtgcg gggagcgcgg cttcttctac      420

acgcccaagg cccgccggga ggcggaggac ctccagggtg agcccccgct gcccccgcta      480

accccacccc ggcttcccgc ctggcgcccc gggggaatcg ggccggagtt ttaaaaaaga      540

aaaaccacat ttcccctggt gacatcccga aaggcccgcg tcgggcaccg agggcccccg      600

tgtgggctcc tgccctggcc cggccctgcg gcccgggagc ctgcggcggg gtgggcgccc      660

cacggccggc acgcgggcgg gcgggcgggc gggcgggcgg gcgggcggga ggcgcggtct      720

gtccctgagc ggccgtccgc cttgctgccc cgcagggaag gacgcggagc tgggggaggc      780

gcctggcgcc ggcggcctgc agccctcggc cctggaggcg cccctgcaga agcggggcat      840

cgtggagcaa tgctgtgcca gcgtctgctc gctgtaccag ctggagcatt actgcaacta      900

gagggcgccc ggagcccgcc gcccctgcgc cccaacccgt ccaataaacc cttgaacgag      960

c                                                                      961


<210>  12
<211>  887
<212>  DNA
<213>  Canis lupus

<400>  12
caccccgaca cggccggcaa acaggtctgt ccccacgggc tccccgccgc cgcctccccg       60

ccagcctgtg ctctcaaggc agcaggagga gaagagctgc ctcggggcct ttgcggggtg      120

ggctcagggt ggggggggcc gtgccccttg ccagcctcaa ccctgcctgt ccccaggtcg      180

ccatggccct ctggatgcgc ctcctgcccc tgctggccct gctggccctc tgggcgcccg      240

cgcccacccg agccttcgtt aaccagcacc tgtgtggctc ccacctggta gaggctctgt      300

acctggtgtg cggggagcgc ggcttcttct acacgcctaa ggcccgccgg gaggtggagg      360

acctgcaggg taagcccccg ccgcccccgc cgcccccgcc ctggctccct acctggcccc      420

aggggcaggc caggtggaaa tattaaaaag aaaaatgact ttcccttggt ctacatcctg      480

caagggacca gctccttggt cagggtcggg caccaaaagc ctgagggcag cctcccacct      540

tggcaccacc ctggggcctg ggagccactg gcacggggtg gggtgggcgg ggcgcgctct      600

ctccctgacc ctgacccgct ctccgcctgg ctcctccgca gtgagggacg tggagctggc      660

cggggcgcct ggcgagggcg gcctgcagcc cctggccctg gagggggccc tgcagaagcg      720

aggcatcgtg gagcagtgct gcaccagcat ctgctccctc taccagctgg agaattactg      780

caactagggg cgcggggggc aggacgtggc agcacctgct gcaggtcacg gtggccgcaa      840

gccttcggct ctctgcaccc caagtgattc aataaaccct ctgaatg                    887


<210>  13
<211>  1431
<212>  DNA
<213>  Homo sapiens

<400>  13
agccctccag gacaggctgc atcagaagag gccatcaagc aggtctgttc caagggcctt       60

tgcgtcaggt gggctcagga ttccagggtg gctggacccc aggccccagc tctgcagcag      120

ggaggacgtg gctgggctcg tgaagcatgt gggggtgagc ccaggggccc caaggcaggg      180

cacctggcct tcagcctgcc tcagccctgc ctgtctccca gatcactgtc cttctgccat      240

ggccctgtgg atgcgcctcc tgcccctgct ggcgctgctg gccctctggg gacctgaccc      300

agccgcagcc tttgtgaacc aacacctgtg cggctcacac ctggtggaag ctctctacct      360

agtgtgcggg gaacgaggct tcttctacac acccaagacc cgccgggagg cagaggacct      420

gcagggtgag ccaactgccc attgctgccc ctggccgccc ccagccaccc cctgctcctg      480

gcgctcccac ccagcatggg cagaaggggg caggaggctg ccacccagca gggggtcagg      540

tgcacttttt taaaaagaag ttctcttggt cacgtcctaa aagtgaccag ctccctgtgg      600

cccagtcaga atctcagcct gaggacggtg ttggcttcgg cagccccgag atacatcaga      660

gggtgggcac gctcctccct ccactcgccc ctcaaacaaa tgccccgcag cccatttctc      720

caccctcatt tgatgaccgc agattcaagt gttttgttaa gtaaagtcct gggtgacctg      780

gggtcacagg gtgccccacg ctgcctgcct ctgggcgaac accccatcac gcccggagga      840

gggcgtggct gcctgcctga gtgggccaga cccctgtcgc caggcctcac ggcagctcca      900

tagtcaggag atggggaaga tgctggggac aggccctggg gagaagtact gggatcacct      960

gttcaggctc ccactgtgac gctgccccgg ggcgggggaa ggaggtggga catgtgggcg     1020

ttggggcctg taggtccaca cccagtgtgg gtgaccctcc ctctaacctg ggtccagccc     1080

ggctggagat gggtgggagt gcgacctagg gctggcgggc aggcgggcac tgtgtctccc     1140

tgactgtgtc ctcctgtgtc cctctgcctc gccgctgttc cggaacctgc tctgcgcggc     1200

acgtcctggc agtggggcag gtggagctgg gcgggggccc tggtgcaggc agcctgcagc     1260

ccttggccct ggaggggtcc ctgcagaagc gtggcattgt ggaacaatgc tgtaccagca     1320

tctgctccct ctaccagctg gagaactact gcaactagac gcagcccgca ggcagcccca     1380

cacccgccgc ctcctgcacc gagagagatg gaataaagcc cttgaaccag c              1431


<210>  14
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly 
            20                  25                  30          


Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
        35                  40                  45              


Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly 
    50                  55                  60                  


Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu 
65                  70                  75                  80  


Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys 
                85                  90                  95      


Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
            100                 105                 110 


