                         SEQUENCE LISTING

<110>  CytomX Therapeutics, Inc.
       Mitra, Sayantan
       Lapuyade, Nicole G.
       Assi, Hikmat H.
       Paidhungat, Madan M.
       Daniel, Dylan L.
       Le Scolan, Erwan
       Bogdanoff, Walter A.
       Cai, Na
       Wang, Hsin
       Berezhnoy, Alexey Y.
 
<120>  MASKED ACTIVATABLE CYTOKINE CONSTRUCTS AND RELATED COMPOSITIONS 
       AND METHODS

<130>  4862-111PCT

<150>  63276893
<151>  2021-11-08

<150>  63161913
<151>  2021-03-16

<150>  63254748
<151>  2021-10-12

<150>  63164827
<151>  2021-03-23

<160>  501   

<170>  PatentIn version 3.5

<210>  1
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  1

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu 
                165 


<210>  2
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  2

Gly Gly Gly Ser 
1               


<210>  3
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  3

Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
        35                  40                  45              


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 


<210>  4
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  4

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser 
225     


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clevable moiety

<400>  5

Leu Ser Gly Arg Ser Asp Asn His 
1               5               


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  6

Thr Gly Arg Gly Pro Ser Trp Val 
1               5               


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  7

Pro Leu Thr Gly Arg Ser Gly Gly 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  8

Thr Ala Arg Gly Pro Ser Phe Lys 
1               5               


<210>  9
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  9

Asn Thr Leu Ser Gly Arg Ser Glu Asn His Ser Gly 
1               5                   10          


<210>  10
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  10

Asn Thr Leu Ser Gly Arg Ser Gly Asn His Gly Ser 
1               5                   10          


<210>  11
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  11

Thr Ser Thr Ser Gly Arg Ser Ala Asn Pro Arg Gly 
1               5                   10          


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  12

Thr Ser Gly Arg Ser Ala Asn Pro 
1               5               


<210>  13
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  13

Val His Met Pro Leu Gly Phe Leu Gly Pro 
1               5                   10  


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  14

Ala Val Gly Leu Leu Ala Pro Pro 
1               5               


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  15

Ala Gln Asn Leu Leu Gly Met Val 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  16

Gln Asn Gln Ala Leu Arg Met Ala 
1               5               


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  17

Leu Ala Ala Pro Leu Gly Leu Leu 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  18

Ser Thr Phe Pro Phe Gly Met Phe 
1               5               


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  19

Ile Ser Ser Gly Leu Leu Ser Ser 
1               5               


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  20

Pro Ala Gly Leu Trp Leu Asp Pro 
1               5               


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  21

Val Ala Gly Arg Ser Met Arg Pro 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavable moiety

<400>  22

Val Val Pro Glu Gly Arg Arg Ser 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  23

Ile Leu Pro Arg Ser Pro Ala Phe 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clevable moiety

<400>  24

Met Val Leu Gly Arg Ser Leu Leu 
1               5               


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  25

Gln Gly Arg Ala Ile Thr Phe Ile 
1               5               


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  26

Ser Pro Arg Ser Ile Met Leu Ala 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  27

Ser Met Leu Arg Ser Met Pro Leu 
1               5               


<210>  28
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  28

Ile Ser Ser Gly Leu Leu Ser Gly Arg Ser Asp Asn His 
1               5                   10              


<210>  29
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  29

Ala Val Gly Leu Leu Ala Pro Pro Gly Gly Leu Ser Gly Arg Ser Asp 
1               5                   10                  15      


Asn His 
        


<210>  30
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  30

Ile Ser Ser Gly Leu Leu Ser Ser Gly Gly Ser Gly Gly Ser Leu Ser 
1               5                   10                  15      


Gly Arg Ser Asp Asn His 
            20          


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  31

Leu Ser Gly Arg Ser Gly Asn His 
1               5               


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moeity

<400>  32

Ser Gly Arg Ser Ala Asn Pro Arg Gly 
1               5                   


<210>  33
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  33

Leu Ser Gly Arg Ser Asp Asp His 
1               5               


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  34

Leu Ser Gly Arg Ser Asp Ile His 
1               5               


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  35

Leu Ser Gly Arg Ser Asp Gln His 
1               5               


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  36

Leu Ser Gly Arg Ser Asp Thr His 
1               5               


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  37

Leu Ser Gly Arg Ser Asp Tyr His 
1               5               


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  38

Leu Ser Gly Arg Ser Asp Asn Pro 
1               5               


<210>  39
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  39

Leu Ser Gly Arg Ser Ala Asn Pro 
1               5               


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  40

Leu Ser Gly Arg Ser Ala Asn Ile 
1               5               


<210>  41
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  41

Leu Ser Gly Arg Ser Asp Asn Ile 
1               5               


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  42

Met Ile Ala Pro Val Ala Tyr Arg 
1               5               


<210>  43
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  43

Arg Pro Ser Pro Met Trp Ala Tyr 
1               5               


<210>  44
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  44

Trp Ala Thr Pro Arg Pro Met Arg 
1               5               


<210>  45
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  45

Phe Arg Leu Leu Asp Trp Gln Trp 
1               5               


<210>  46
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  46

Ile Ser Ser Gly Leu 
1               5   


<210>  47
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  47

Ile Ser Ser Gly Leu Leu Ser 
1               5           


<210>  48
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  48

Ile Ser Ser Gly Leu Leu 
1               5       


<210>  49
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  49

Ile Ser Ser Gly Leu Leu Ser Gly Arg Ser Ala Asn Pro Arg Gly 
1               5                   10                  15  


<210>  50
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  50

Ala Val Gly Leu Leu Ala Pro Pro Thr Ser Gly Arg Ser Ala Asn Pro 
1               5                   10                  15      


Arg Gly 
        


<210>  51
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  51

Ala Val Gly Leu Leu Ala Pro Pro Ser Gly Arg Ser Ala Asn Pro Arg 
1               5                   10                  15      


Gly 
    


<210>  52
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  52

Ile Ser Ser Gly Leu Leu Ser Gly Arg Ser Asp Asp His 
1               5                   10              


<210>  53
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  53

Ile Ser Ser Gly Leu Leu Ser Gly Arg Ser Asp Ile His 
1               5                   10              


<210>  54
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  54

Ile Ser Ser Gly Leu Leu Ser Gly Arg Ser Asp Gln His 
1               5                   10              


<210>  55
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  55

Ile Ser Ser Gly Leu Leu Ser Gly Arg Ser Asp Thr His 
1               5                   10              


<210>  56
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  56

Ile Ser Ser Gly Leu Leu Ser Gly Arg Ser Asp Tyr His 
1               5                   10              


<210>  57
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  57

Ile Ser Ser Gly Leu Leu Ser Gly Arg Ser Asp Asn Pro 
1               5                   10              


<210>  58
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  58

Ile Ser Ser Gly Leu Leu Ser Gly Arg Ser Ala Asn Pro 
1               5                   10              


<210>  59
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  59

Ile Ser Ser Gly Leu Leu Ser Gly Arg Ser Ala Asn Ile 
1               5                   10              


<210>  60
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  60

Ala Val Gly Leu Leu Ala Pro Pro Gly Gly Leu Ser Gly Arg Ser Asp 
1               5                   10                  15      


Asp His 
        


<210>  61
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  61

Ala Val Gly Leu Leu Ala Pro Pro Gly Gly Leu Ser Gly Arg Ser Asp 
1               5                   10                  15      


Ile His 
        


<210>  62
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  62

Ala Val Gly Leu Leu Ala Pro Pro Gly Gly Leu Ser Gly Arg Ser Asp 
1               5                   10                  15      


Gln His 
        


<210>  63
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  63

Ala Val Gly Leu Leu Ala Pro Pro Gly Gly Leu Ser Gly Arg Ser Asp 
1               5                   10                  15      


Thr His 
        


<210>  64
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moeity

<400>  64

Ala Val Gly Leu Leu Ala Pro Pro Gly Gly Leu Ser Gly Arg Ser Asp 
1               5                   10                  15      


Tyr His 
        


<210>  65
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  65

Ala Val Gly Leu Leu Ala Pro Pro Gly Gly Leu Ser Gly Arg Ser Asp 
1               5                   10                  15      


Asn Pro 
        


<210>  66
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  66

Ala Val Gly Leu Leu Ala Pro Pro Gly Gly Leu Ser Gly Arg Ser Ala 
1               5                   10                  15      


Asn Pro 
        


<210>  67
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  67

Ala Val Gly Leu Leu Ala Pro Pro Gly Gly Leu Ser Gly Arg Ser Ala 
1               5                   10                  15      


Asn Ile 
        


<210>  68
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  68

Ile Ser Ser Gly Leu Leu Ser Gly Arg Ser Asp Asn Ile 
1               5                   10              


<210>  69
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  69

Ala Val Gly Leu Leu Ala Pro Pro Gly Gly Leu Ser Gly Arg Ser Asp 
1               5                   10                  15      


Asn Ile 
        


<210>  70
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  70

Gly Leu Ser Gly Arg Ser Asp Asn His Gly Gly Ala Val Gly Leu Leu 
1               5                   10                  15      


Ala Pro Pro 
            


<210>  71
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  71

Gly Leu Ser Gly Arg Ser Asp Asn His Gly Gly Val His Met Pro Leu 
1               5                   10                  15      


Gly Phe Leu Gly Pro 
            20      


<210>  72
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  72

Leu Ser Gly Arg Ser Asp Asn His Gly Gly Val His Met Pro Leu Gly 
1               5                   10                  15      


Phe Leu Gly Pro 
            20  


<210>  73
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  73

Ile Ser Ser Gly Leu Ser Ser 
1               5           


<210>  74
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  74

Pro Val Gly Tyr Thr Ser Ser Leu 
1               5               


<210>  75
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  75

Asp Trp Leu Tyr Trp Pro Gly Ile 
1               5               


<210>  76
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  76

Leu Lys Ala Ala Pro Arg Trp Ala 
1               5               


<210>  77
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  77

Gly Pro Ser His Leu Val Leu Thr 
1               5               


<210>  78
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  78

Leu Pro Gly Gly Leu Ser Pro Trp 
1               5               


<210>  79
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  79

Met Gly Leu Phe Ser Glu Ala Gly 
1               5               


<210>  80
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  80

Ser Pro Leu Pro Leu Arg Val Pro 
1               5               


<210>  81
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  81

Arg Met His Leu Arg Ser Leu Gly 
1               5               


<210>  82
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  82

Leu Leu Ala Pro Ser His Arg Ala 
1               5               


<210>  83
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  83

Gly Pro Arg Ser Phe Gly Leu 
1               5           


<210>  84
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  84

Gly Pro Arg Ser Phe Gly 
1               5       


<210>  85
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  85

Ser Ala Arg Gly Pro Ser Arg Trp 
1               5               


<210>  86
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  86

Gly Gly Trp His Thr Gly Arg Asn 
1               5               


<210>  87
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  87

His Thr Gly Arg Ser Gly Ala Leu 
1               5               


<210>  88
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  88

Ala Ala Arg Gly Pro Ala Ile His 
1               5               


<210>  89
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  89

Arg Gly Pro Ala Phe Asn Pro Met 
1               5               


<210>  90
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  90

Ser Ser Arg Gly Pro Ala Tyr Leu 
1               5               


<210>  91
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  91

Arg Gly Pro Ala Thr Pro Ile Met 
1               5               


<210>  92
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  92

Arg Gly Pro Ala 
1               


<210>  93
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  93

Gly Gly Gln Pro Ser Gly Met Trp Gly Trp 
1               5                   10  


<210>  94
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  94

Phe Pro Arg Pro Leu Gly Ile Thr Gly Leu 
1               5                   10  


<210>  95
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  95

Ser Pro Leu Thr Gly Arg Ser Gly 
1               5               


<210>  96
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  96

Ser Ala Gly Phe Ser Leu Pro Ala 
1               5               


<210>  97
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  97

Leu Ala Pro Leu Gly Leu Gln Arg Arg 
1               5                   


<210>  98
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  98

Ser Gly Gly Pro Leu Gly Val Arg 
1               5               


<210>  99
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  99

Pro Leu Gly Leu 
1               


<210>  100
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  100

Ser Gly Arg Ser Asp Asn Ile 
1               5           


<210>  101
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  101

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Lys Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu 
                165 


<210>  102
<211>  169
<212>  PRT
<213>  Rattus rattus

<400>  102

Cys Asp Leu Pro His Thr His Asn Leu Arg Asn Lys Arg Ala Phe Thr 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Leu Ser Pro Val Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg Lys Asp Phe Gly Phe Pro Leu Glu Lys Val Asp Gly Gln Gln Ile 
        35                  40                  45              


Gln Lys Ala Gln Ala Ile Pro Val Leu His Glu Leu Thr Gln Gln Ile 
    50                  55                  60                  


Leu Ser Leu Phe Thr Ser Lys Glu Ser Ser Thr Ala Trp Asp Ala Ser 
65                  70                  75                  80  


Leu Leu Asp Ser Phe Cys Asn Asp Leu Gln Gln Gln Leu Ser Gly Leu 
                85                  90                  95      


Gln Ala Cys Leu Met Gln Gln Val Gly Val Gln Glu Ser Pro Leu Thr 
            100                 105                 110         


Gln Glu Asp Ser Leu Leu Ala Val Arg Glu Tyr Phe His Arg Ile Thr 
        115                 120                 125             


Val Tyr Leu Arg Glu Lys Lys His Ser Pro Cys Ala Trp Glu Val Val 
    130                 135                 140                 


Arg Ala Glu Val Trp Arg Ala Leu Ser Ser Ser Ala Asn Leu Leu Gly 
145                 150                 155                 160 


Arg Leu Arg Glu Glu Arg Asn Glu Ser 
                165                 


<210>  103
<211>  167
<212>  PRT
<213>  Mus musculus

<400>  103

Cys Asp Leu Pro His Thr Tyr Asn Leu Arg Asn Lys Arg Ala Leu Lys 
1               5                   10                  15      


Val Leu Ala Gln Met Arg Arg Leu Pro Phe Leu Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg Gln Asp Phe Gly Phe Pro Leu Glu Lys Val Asp Asn Gln Gln Ile 
        35                  40                  45              


Gln Lys Ala Gln Ala Ile Pro Val Leu Arg Asp Leu Thr Gln Gln Thr 
    50                  55                  60                  


Leu Asn Leu Phe Thr Ser Lys Ala Ser Ser Ala Ala Trp Asn Ala Thr 
65                  70                  75                  80  


Leu Leu Asp Ser Phe Cys Asn Asp Leu His Gln Gln Leu Asn Asp Leu 
                85                  90                  95      


Gln Thr Cys Leu Met Gln Gln Val Gly Val Gln Glu Pro Pro Leu Thr 
            100                 105                 110         


Gln Glu Asp Ala Leu Leu Ala Val Arg Lys Tyr Phe His Arg Ile Thr 
        115                 120                 125             


Val Tyr Leu Arg Glu Lys Lys His Ser Pro Cys Ala Trp Glu Val Val 
    130                 135                 140                 


Arg Ala Glu Val Trp Arg Ala Leu Ser Ser Ser Val Asn Leu Leu Pro 
145                 150                 155                 160 


Arg Leu Ser Glu Glu Lys Glu 
                165         


<210>  104
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  104

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu 
                165 


<210>  105
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  105

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Lys Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser 
                165                 170                 175     


Arg Arg Thr Leu Met Leu Leu Ala Gln Met Arg Arg Ile Ser Leu Phe 
            180                 185                 190         


Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe 
        195                 200                 205             


Gly Asn Gln Phe Gln Lys Ala Glu Thr Ile Pro Val Leu His Glu Met 
    210                 215                 220                 


Ile Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala 
225                 230                 235                 240 


Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln 
                245                 250                 255     


Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu 
            260                 265                 270         


Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe 
        275                 280                 285             


Gln Arg Ile Thr Leu Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala 
    290                 295                 300                 


Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr 
305                 310                 315                 320 


Asn Leu Gln Glu Ser Leu Arg Ser Lys Glu Cys Asp Leu Pro Gln Thr 
                325                 330                 335     


His Ser Leu Gly Ser Arg Arg Thr Leu Met Leu Leu Ala Gln Met Arg 
            340                 345                 350         


Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp Arg Arg Asp Phe Gly Phe 
        355                 360                 365             


Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln Lys Ala Glu Thr Ile Pro 
    370                 375                 380                 


Val Leu His Glu Met Ile Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys 
385                 390                 395                 400 


Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr 
                405                 410                 415     


Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Gly 
            420                 425                 430         


Val Gly Val Thr Glu Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala 
        435                 440                 445             


Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Lys Glu Lys Lys 
    450                 455                 460                 


Tyr Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser 
465                 470                 475                 480 


Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser Leu Arg Ser Lys Glu 
                485                 490                 495 


<210>  106
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Ser Tyr Asn Leu Leu Gly Phe Leu Gln Arg Ser Ser Asn Phe Gln 
1               5                   10                  15      


Cys Gln Lys Leu Leu Trp Gln Leu Asn Gly Arg Leu Glu Tyr Cys Leu 
            20                  25                  30          


Lys Asp Arg Met Asn Phe Asp Ile Pro Glu Glu Ile Lys Gln Leu Gln 
        35                  40                  45              


Gln Phe Gln Lys Glu Asp Ala Ala Leu Thr Ile Tyr Glu Met Leu Gln 
    50                  55                  60                  


Asn Ile Phe Ala Ile Phe Arg Gln Asp Ser Ser Ser Thr Gly Trp Asn 
65                  70                  75                  80  


Glu Thr Ile Val Glu Asn Leu Leu Ala Asn Val Tyr His Gln Ile Asn 
                85                  90                  95      


His Leu Lys Thr Val Leu Glu Glu Lys Leu Glu Lys Glu Asp Phe Thr 
            100                 105                 110         


Arg Gly Lys Leu Met Ser Ser Leu His Leu Lys Arg Tyr Tyr Gly Arg 
        115                 120                 125             


Ile Leu His Tyr Leu Lys Ala Lys Glu Tyr Ser His Cys Ala Trp Thr 
    130                 135                 140                 


Ile Val Arg Val Glu Ile Leu Arg Asn Phe Tyr Phe Ile Asn Arg Leu 
145                 150                 155                 160 


Thr Gly Tyr Leu Arg Asn 
                165     


<210>  107
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  107

Ser Tyr Asn Leu Leu Gly Phe Leu Gln Arg Ser Ser Asn Phe Gln Ser 
1               5                   10                  15      


Gln Lys Leu Leu Trp Gln Leu Asn Gly Arg Leu Glu Tyr Cys Leu Lys 
            20                  25                  30          


Asp Arg Met Asn Phe Asp Ile Pro Glu Glu Ile Lys Gln Leu Gln Gln 
        35                  40                  45              


Phe Gln Lys Glu Asp Ala Ala Leu Thr Ile Tyr Glu Met Leu Gln Asn 
    50                  55                  60                  


Ile Phe Ala Ile Phe Arg Gln Asp Ser Ser Ser Thr Gly Trp Asn Glu 
65                  70                  75                  80  


Thr Ile Val Glu Asn Leu Leu Ala Asn Val Tyr His Gln Ile Asn His 
                85                  90                  95      


Leu Lys Thr Val Leu Glu Glu Lys Leu Glu Lys Glu Asp Phe Thr Arg 
            100                 105                 110         


Gly Lys Leu Met Ser Ser Leu His Leu Lys Arg Tyr Tyr Gly Arg Ile 
        115                 120                 125             


Leu His Tyr Leu Lys Ala Lys Glu Tyr Ser His Cys Ala Trp Thr Ile 
    130                 135                 140                 


Val Arg Val Glu Ile Leu Arg Asn Phe Tyr Phe Ile Asn Arg Leu Thr 
145                 150                 155                 160 


Gly Tyr Leu Arg Asn 
                165 


<210>  108
<211>  182
<212>  PRT
<213>  Mus musculus

<400>  108

Met Asn Asn Arg Trp Ile Leu His Ala Ala Phe Leu Leu Cys Phe Ser 
1               5                   10                  15      


Thr Thr Ala Leu Ser Ile Asn Tyr Lys Gln Leu Gln Leu Gln Glu Arg 
            20                  25                  30          


Thr Asn Ile Arg Lys Cys Gln Glu Leu Leu Glu Gln Leu Asn Gly Lys 
        35                  40                  45              


Ile Asn Leu Thr Tyr Arg Ala Asp Phe Lys Ile Pro Met Glu Met Thr 
    50                  55                  60                  


Glu Lys Met Gln Lys Ser Tyr Thr Ala Phe Ala Ile Gln Glu Met Leu 
65                  70                  75                  80  


Gln Asn Val Phe Leu Val Phe Arg Asn Asn Phe Ser Ser Thr Gly Trp 
                85                  90                  95      


Asn Glu Thr Ile Val Val Arg Leu Leu Asp Glu Leu His Gln Gln Thr 
            100                 105                 110         


Val Phe Leu Lys Thr Val Leu Glu Glu Lys Gln Glu Glu Arg Leu Thr 
        115                 120                 125             


Trp Glu Met Ser Ser Thr Ala Leu His Leu Lys Ser Tyr Tyr Trp Arg 
    130                 135                 140                 


Val Gln Arg Tyr Leu Lys Leu Met Lys Tyr Asn Ser Tyr Ala Trp Met 
145                 150                 155                 160 


Val Val Arg Ala Glu Ile Phe Arg Asn Phe Leu Ile Ile Arg Arg Leu 
                165                 170                 175     


Thr Arg Asn Phe Gln Asn 
            180         


<210>  109
<211>  184
<212>  PRT
<213>  Rattus rattus

<400>  109

Met Ala Asn Arg Trp Thr Leu His Ile Ala Phe Leu Leu Cys Phe Ser 
1               5                   10                  15      


Thr Thr Ala Leu Ser Ile Asp Tyr Lys Gln Leu Gln Phe Arg Gln Ser 
            20                  25                  30          


Thr Ser Ile Arg Thr Cys Gln Lys Leu Leu Arg Gln Leu Asn Gly Arg 
        35                  40                  45              


Leu Asn Leu Ser Tyr Arg Thr Asp Phe Lys Ile Pro Met Glu Val Met 
    50                  55                  60                  


His Pro Ser Gln Met Glu Lys Ser Tyr Thr Ala Phe Ala Ile Gln Val 
65                  70                  75                  80  


Met Leu Gln Asn Val Phe Leu Val Phe Arg Ser Asn Phe Ser Ser Thr 
                85                  90                  95      


Gly Trp Asn Glu Thr Ile Val Glu Ser Leu Leu Asp Glu Leu His Gln 
            100                 105                 110         


Gln Thr Glu Leu Leu Glu Ile Ile Leu Lys Glu Lys Gln Glu Glu Arg 
        115                 120                 125             


Leu Thr Trp Val Thr Ser Thr Thr Thr Leu Gly Leu Lys Ser Tyr Tyr 
    130                 135                 140                 


Trp Arg Val Gln Arg Tyr Leu Lys Asp Lys Lys Tyr Asn Ser Tyr Ala 
145                 150                 155                 160 


Trp Met Val Val Arg Ala Glu Val Phe Arg Asn Phe Ser Ile Ile Leu 
                165                 170                 175     


Arg Leu Asn Arg Asn Phe Gln Asn 
            180                 


<210>  110
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Cys Asp Leu Pro Gln Asn His Gly Leu Leu Ser Arg Asn Thr Leu 
1               5                   10                  15      


Val Leu Leu His Gln Met Arg Arg Ile Ser Pro Phe Leu Cys Leu Lys 
            20                  25                  30          


Asp Arg Arg Asp Phe Arg Phe Pro Gln Glu Met Val Lys Gly Ser Gln 
        35                  40                  45              


Leu Gln Lys Ala His Val Met Ser Val Leu His Glu Met Leu Gln Gln 
    50                  55                  60                  


Ile Phe Ser Leu Phe His Thr Glu Arg Ser Ser Ala Ala Trp Asn Met 
65                  70                  75                  80  


Thr Leu Leu Asp Gln Leu His Thr Gly Leu His Gln Gln Leu Gln His 
                85                  90                  95      


Leu Glu Thr Cys Leu Leu Gln Val Val Gly Glu Gly Glu Ser Ala Gly 
            100                 105                 110         


Ala Ile Ser Ser Pro Ala Leu Thr Leu Arg Arg Tyr Phe Gln Gly Ile 
        115                 120                 125             


Arg Val Tyr Leu Lys Glu Lys Lys Tyr Ser Asp Cys Ala Trp Glu Val 
    130                 135                 140                 


Val Arg Met Glu Ile Met Lys Ser Leu Phe Leu Ser Thr Asn Met Gln 
145                 150                 155                 160 


Glu Arg Leu Arg Ser Lys Asp Arg Asp Leu Gly Ser Ser 
                165                 170             


<210>  111
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  111

Met Ala Lys Val Pro Asp Met Phe Glu Asp Leu Lys Asn Cys Tyr Ser 
1               5                   10                  15      


Glu Asn Glu Glu Asp Ser Ser Ser Ile Asp His Leu Ser Leu Asn Gln 
            20                  25                  30          


Lys Ser Phe Tyr His Val Ser Tyr Gly Pro Leu His Glu Gly Cys Met 
        35                  40                  45              


Asp Gln Ser Val Ser Leu Ser Ile Ser Glu Thr Ser Lys Thr Ser Lys 
    50                  55                  60                  


Leu Thr Phe Lys Glu Ser Met Val Val Val Ala Thr Asn Gly Lys Val 
65                  70                  75                  80  


Leu Lys Lys Arg Arg Leu Ser Leu Ser Gln Ser Ile Thr Asp Asp Asp 
                85                  90                  95      


Leu Glu Ala Ile Ala Asn Asp Ser Glu Glu Glu Ile Ile Lys Pro Arg 
            100                 105                 110         


Ser Ala Pro Phe Ser Phe Leu Ser Asn Val Lys Tyr Asn Phe Met Arg 
        115                 120                 125             


Ile Ile Lys Tyr Glu Phe Ile Leu Asn Asp Ala Leu Asn Gln Ser Ile 
    130                 135                 140                 


Ile Arg Ala Asn Asp Gln Tyr Leu Thr Ala Ala Ala Leu His Asn Leu 
145                 150                 155                 160 


Asp Glu Ala Val Lys Phe Asp Met Gly Ala Tyr Lys Ser Ser Lys Asp 
                165                 170                 175     


Asp Ala Lys Ile Thr Val Ile Leu Arg Ile Ser Lys Thr Gln Leu Tyr 
            180                 185                 190         


Val Thr Ala Gln Asp Glu Asp Gln Pro Val Leu Leu Lys Glu Met Pro 
        195                 200                 205             


Glu Ile Pro Lys Thr Ile Thr Gly Ser Glu Thr Asn Leu Leu Phe Phe 
    210                 215                 220                 


Trp Glu Thr His Gly Thr Lys Asn Tyr Phe Thr Ser Val Ala His Pro 
225                 230                 235                 240 


Asn Leu Phe Ile Ala Thr Lys Gln Asp Tyr Trp Val Cys Leu Ala Gly 
                245                 250                 255     


Gly Pro Pro Ser Ile Thr Asp Phe Gln Ile Leu Glu Asn Gln Ala 
            260                 265                 270     


<210>  112
<211>  270
<212>  PRT
<213>  Mus musculus

<400>  112

Met Ala Lys Val Pro Asp Leu Phe Glu Asp Leu Lys Asn Cys Tyr Ser 
1               5                   10                  15      


Glu Asn Glu Asp Tyr Ser Ser Ala Ile Asp His Leu Ser Leu Asn Gln 
            20                  25                  30          


Lys Ser Phe Tyr Asp Ala Ser Tyr Gly Ser Leu His Glu Thr Cys Thr 
        35                  40                  45              


Asp Gln Phe Val Ser Leu Arg Thr Ser Glu Thr Ser Lys Met Ser Asn 
    50                  55                  60                  


Phe Thr Phe Lys Glu Ser Arg Val Thr Val Ser Ala Thr Ser Ser Asn 
65                  70                  75                  80  


Gly Lys Ile Leu Lys Lys Arg Arg Leu Ser Phe Ser Glu Thr Phe Thr 
                85                  90                  95      


Glu Asp Asp Leu Gln Ser Ile Thr His Asp Leu Glu Glu Thr Ile Gln 
            100                 105                 110         


Pro Arg Ser Ala Pro Tyr Thr Tyr Gln Ser Asp Leu Arg Tyr Lys Leu 
        115                 120                 125             


Met Lys Leu Val Arg Gln Lys Phe Val Met Asn Asp Ser Leu Asn Gln 
    130                 135                 140                 


Thr Ile Tyr Gln Asp Val Asp Lys His Tyr Leu Ser Thr Thr Trp Leu 
145                 150                 155                 160 


Asn Asp Leu Gln Gln Glu Val Lys Phe Asp Met Tyr Ala Tyr Ser Ser 
                165                 170                 175     


Gly Gly Asp Asp Ser Lys Tyr Pro Val Thr Leu Lys Ile Ser Asp Ser 
            180                 185                 190         


Gln Leu Phe Val Ser Ala Gln Gly Glu Asp Gln Pro Val Leu Leu Lys 
        195                 200                 205             


Glu Leu Pro Glu Thr Pro Lys Leu Ile Thr Gly Ser Glu Thr Asp Leu 
    210                 215                 220                 


Ile Phe Phe Trp Lys Ser Ile Asn Ser Lys Asn Tyr Phe Thr Ser Ala 
225                 230                 235                 240 


Ala Tyr Pro Glu Leu Phe Ile Ala Thr Lys Glu Gln Ser Arg Val His 
                245                 250                 255     


Leu Ala Arg Gly Leu Pro Ser Met Thr Asp Phe Gln Ile Ser 
            260                 265                 270 


<210>  113
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  113

Met Ala Glu Val Pro Glu Leu Ala Ser Glu Met Met Ala Tyr Tyr Ser 
1               5                   10                  15      


Gly Asn Glu Asp Asp Leu Phe Phe Glu Ala Asp Gly Pro Lys Gln Met 
            20                  25                  30          


Lys Cys Ser Phe Gln Asp Leu Asp Leu Cys Pro Leu Asp Gly Gly Ile 
        35                  40                  45              


Gln Leu Arg Ile Ser Asp His His Tyr Ser Lys Gly Phe Arg Gln Ala 
    50                  55                  60                  


Ala Ser Val Val Val Ala Met Asp Lys Leu Arg Lys Met Leu Val Pro 
65                  70                  75                  80  


Cys Pro Gln Thr Phe Gln Glu Asn Asp Leu Ser Thr Phe Phe Pro Phe 
                85                  90                  95      


Ile Phe Glu Glu Glu Pro Ile Phe Phe Asp Thr Trp Asp Asn Glu Ala 
            100                 105                 110         


Tyr Val His Asp Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp 
        115                 120                 125             


Ser Gln Gln Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala 
    130                 135                 140                 


Leu His Leu Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met 
145                 150                 155                 160 


Ser Phe Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu 
                165                 170                 175     


Gly Leu Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp 
            180                 185                 190         


Lys Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys 
        195                 200                 205             


Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn 
    210                 215                 220                 


Lys Leu Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr 
225                 230                 235                 240 


Ser Gln Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly 
                245                 250                 255     


Gln Asp Ile Thr Asp Phe Thr Met Gln Phe Val Ser Ser 
            260                 265                 


<210>  114
<211>  269
<212>  PRT
<213>  Mus musculus

<400>  114

Met Ala Thr Val Pro Glu Leu Asn Cys Glu Met Pro Pro Phe Asp Ser 
1               5                   10                  15      


Asp Glu Asn Asp Leu Phe Phe Glu Val Asp Gly Pro Gln Lys Met Lys 
            20                  25                  30          


Gly Cys Phe Gln Thr Phe Asp Leu Gly Cys Pro Asp Glu Ser Ile Gln 
        35                  40                  45              


Leu Gln Ile Ser Gln Gln His Ile Asn Lys Ser Phe Arg Gln Ala Val 
    50                  55                  60                  


Ser Leu Ile Val Ala Val Glu Lys Leu Trp Gln Leu Pro Val Ser Phe 
65                  70                  75                  80  


Pro Trp Thr Phe Gln Asp Glu Asp Met Ser Thr Phe Phe Ser Phe Ile 
                85                  90                  95      


Phe Glu Glu Glu Pro Ile Leu Cys Asp Ser Trp Asp Asp Asp Asp Asn 
            100                 105                 110         


Leu Leu Val Cys Asp Val Pro Ile Arg Gln Leu His Tyr Arg Leu Arg 
        115                 120                 125             


Asp Glu Gln Gln Lys Ser Leu Val Leu Ser Asp Pro Tyr Glu Leu Lys 
    130                 135                 140                 


Ala Leu His Leu Asn Gly Gln Asn Ile Asn Gln Gln Val Ile Phe Ser 
145                 150                 155                 160 


Met Ser Phe Val Gln Gly Glu Pro Ser Asn Asp Lys Ile Pro Val Ala 
                165                 170                 175     


Leu Gly Leu Lys Gly Lys Asn Leu Tyr Leu Ser Cys Val Met Lys Asp 
            180                 185                 190         


Gly Thr Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Gln Tyr Pro 
        195                 200                 205             


Lys Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Val Lys 
    210                 215                 220                 


Ser Lys Val Glu Phe Glu Ser Ala Glu Phe Pro Asn Trp Tyr Ile Ser 
225                 230                 235                 240 


Thr Ser Gln Ala Glu His Lys Pro Val Phe Leu Gly Asn Asn Ser Gly 
                245                 250                 255     


Gln Asp Ile Ile Asp Phe Thr Met Glu Ser Val Ser Ser 
            260                 265                 


<210>  115
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  115

Met Glu Ile Cys Arg Gly Leu Arg Ser His Leu Ile Thr Leu Leu Leu 
1               5                   10                  15      


Phe Leu Phe His Ser Glu Thr Ile Cys Arg Pro Ser Gly Arg Lys Ser 
            20                  25                  30          


Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe 
        35                  40                  45              


Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn 
    50                  55                  60                  


Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala 
65                  70                  75                  80  


Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys 
                85                  90                  95      


Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp 
            100                 105                 110         


Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser 
        115                 120                 125             


Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp 
    130                 135                 140                 


Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn 
145                 150                 155                 160 


Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp 
                165                 170                 175     


Glu 
    


<210>  116
<211>  178
<212>  PRT
<213>  Mus musculus

<400>  116

Met Glu Ile Cys Trp Gly Pro Tyr Ser His Leu Ile Ser Leu Leu Leu 
1               5                   10                  15      


Ile Leu Leu Phe His Ser Glu Ala Ala Cys Arg Pro Ser Gly Lys Arg 
            20                  25                  30          


Pro Cys Lys Met Gln Ala Phe Arg Ile Trp Asp Thr Asn Gln Lys Thr 
        35                  40                  45              


Phe Tyr Leu Arg Asn Asn Gln Leu Ile Ala Gly Tyr Leu Gln Gly Pro 
    50                  55                  60                  


Asn Ile Lys Leu Glu Glu Lys Ile Asp Met Val Pro Ile Asp Leu His 
65                  70                  75                  80  


Ser Val Phe Leu Gly Ile His Gly Gly Lys Leu Cys Leu Ser Cys Ala 
                85                  90                  95      


Lys Ser Gly Asp Asp Ile Lys Leu Gln Leu Glu Glu Val Asn Ile Thr 
            100                 105                 110         


Asp Leu Ser Lys Asn Lys Glu Glu Asp Lys Arg Phe Thr Phe Ile Arg 
        115                 120                 125             


Ser Glu Lys Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly 
    130                 135                 140                 


Trp Phe Leu Cys Thr Thr Leu Glu Ala Asp Arg Pro Val Ser Leu Thr 
145                 150                 155                 160 


Asn Thr Pro Glu Glu Pro Leu Ile Val Thr Lys Phe Tyr Phe Gln Glu 
                165                 170                 175     


Asp Gln 
        


<210>  117
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  117

Met Ala Ala Glu Pro Val Glu Asp Asn Cys Ile Asn Phe Val Ala Met 
1               5                   10                  15      


Lys Phe Ile Asp Asn Thr Leu Tyr Phe Ile Ala Glu Asp Asp Glu Asn 
            20                  25                  30          


Leu Glu Ser Asp Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile 
        35                  40                  45              


Arg Asn Leu Asn Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro 
    50                  55                  60                  


Leu Phe Glu Asp Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg 
65                  70                  75                  80  


Thr Ile Phe Ile Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met 
                85                  90                  95      


Ala Val Thr Ile Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys 
            100                 105                 110         


Glu Asn Lys Ile Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile 
        115                 120                 125             


Lys Asp Thr Lys Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly 
    130                 135                 140                 


His Asp Asn Lys Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe 
145                 150                 155                 160 


Leu Ala Cys Glu Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys 
                165                 170                 175     


Glu Asp Glu Leu Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu 
            180                 185                 190         


Asp 
    


<210>  118
<211>  192
<212>  PRT
<213>  Mus musculus

<400>  118

Met Ala Ala Met Ser Glu Asp Ser Cys Val Asn Phe Lys Glu Met Met 
1               5                   10                  15      


Phe Ile Asp Asn Thr Leu Tyr Phe Ile Pro Glu Glu Asn Gly Asp Leu 
            20                  25                  30          


Glu Ser Asp Asn Phe Gly Arg Leu His Cys Thr Thr Ala Val Ile Arg 
        35                  40                  45              


Asn Ile Asn Asp Gln Val Leu Phe Val Asp Lys Arg Gln Pro Val Phe 
    50                  55                  60                  


Glu Asp Met Thr Asp Ile Asp Gln Ser Ala Ser Glu Pro Gln Thr Arg 
65                  70                  75                  80  


Leu Ile Ile Tyr Met Tyr Lys Asp Ser Glu Val Arg Gly Leu Ala Val 
                85                  90                  95      


Thr Leu Ser Val Lys Asp Ser Lys Met Ser Thr Leu Ser Cys Lys Asn 
            100                 105                 110         


Lys Ile Ile Ser Phe Glu Glu Met Asp Pro Pro Glu Asn Ile Asp Asp 
        115                 120                 125             


Ile Gln Ser Asp Leu Ile Phe Phe Gln Lys Arg Val Pro Gly His Asn 
    130                 135                 140                 


Lys Met Glu Phe Glu Ser Ser Leu Tyr Glu Gly His Phe Leu Ala Cys 
145                 150                 155                 160 


Gln Lys Glu Asp Asp Ala Phe Lys Leu Ile Leu Lys Lys Lys Asp Glu 
                165                 170                 175     


Asn Gly Asp Lys Ser Val Met Phe Thr Leu Thr Asn Leu His Gln Ser 
            180                 185                 190         


<210>  119
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  119

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser 
145                 150 


<210>  120
<211>  169
<212>  PRT
<213>  Mus musculus

<400>  120

Met Tyr Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu 
1               5                   10                  15      


Leu Val Asn Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala 
            20                  25                  30          


Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu 
        35                  40                  45              


Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn 
    50                  55                  60                  


Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu 
65                  70                  75                  80  


Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu 
                85                  90                  95      


Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe 
            100                 105                 110         


Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val 
        115                 120                 125             


Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp 
    130                 135                 140                 


Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys 
145                 150                 155                 160 


Gln Ser Ile Ile Ser Thr Ser Pro Gln 
                165                 


<210>  121
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  121

Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala 
1               5                   10                  15      


Cys Ala Gly Asn Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln 
            20                  25                  30          


Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 
        35                  40                  45              


Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr 
    50                  55                  60                  


Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 
65                  70                  75                  80  


Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 
                85                  90                  95      


Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 
            100                 105                 110         


Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 
        115                 120                 125             


Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 
    130                 135                 140                 


Arg Glu Lys Tyr Ser Lys Cys Ser Ser 
145                 150             


<210>  122
<211>  140
<212>  PRT
<213>  Mus musculus

<400>  122

Met Gly Leu Asn Pro Gln Leu Val Val Ile Leu Leu Phe Phe Leu Glu 
1               5                   10                  15      


Cys Thr Arg Ser His Ile His Gly Cys Asp Lys Asn His Leu Arg Glu 
            20                  25                  30          


Ile Ile Gly Ile Leu Asn Glu Val Thr Gly Glu Gly Thr Pro Cys Thr 
        35                  40                  45              


Glu Met Asp Val Pro Asn Val Leu Thr Ala Thr Lys Asn Thr Thr Glu 
    50                  55                  60                  


Ser Glu Leu Val Cys Arg Ala Ser Lys Val Leu Arg Ile Phe Tyr Leu 
65                  70                  75                  80  


Lys His Gly Lys Thr Pro Cys Leu Lys Lys Asn Ser Ser Val Leu Met 
                85                  90                  95      


Glu Leu Gln Arg Leu Phe Arg Ala Phe Arg Cys Leu Asp Ser Ser Ile 
            100                 105                 110         


Ser Cys Thr Met Asn Glu Ser Lys Ser Thr Ser Leu Lys Asp Phe Leu 
        115                 120                 125             


Glu Ser Leu Lys Ser Ile Met Gln Met Asp Tyr Ser 
    130                 135                 140 


<210>  123
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  123

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
65                  70                  75                  80  


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
                85                  90                  95      


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
            100                 105                 110         


Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 
        115                 120                 125             


Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 
    130                 135                 140                 


Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 
145                 150                 155                 160 


Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 
                165                 170                 175     


His 
    


<210>  124
<211>  154
<212>  PRT
<213>  Mus musculus

<400>  124

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Ile Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Thr Ser Ser Glu Cys His Ile Lys Asp Lys 
            20                  25                  30          


Glu Gly Lys Ala Tyr Glu Ser Val Leu Met Ile Ser Ile Asp Glu Leu 
        35                  40                  45              


Asp Lys Met Thr Gly Thr Asp Ser Asn Cys Pro Asn Asn Glu Pro Asn 
    50                  55                  60                  


Phe Phe Arg Lys His Val Cys Asp Asp Thr Lys Glu Ala Ala Phe Leu 
65                  70                  75                  80  


Asn Arg Ala Ala Arg Lys Leu Lys Gln Phe Leu Lys Met Asn Ile Ser 
                85                  90                  95      


Glu Glu Phe Asn Val His Leu Leu Thr Val Ser Gln Gly Thr Gln Thr 
            100                 105                 110         


Leu Val Asn Cys Thr Ser Lys Glu Glu Lys Asn Val Lys Glu Gln Lys 
        115                 120                 125             


Lys Asn Asp Ala Cys Phe Leu Lys Arg Leu Leu Arg Glu Ile Lys Thr 
    130                 135                 140                 


Cys Trp Asn Lys Ile Leu Lys Gly Ser Ile 
145                 150                 


<210>  125
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  125

Met Leu Leu Ala Met Val Leu Thr Ser Ala Leu Leu Leu Cys Ser Val 
1               5                   10                  15      


Ala Gly Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe 
            20                  25                  30          


Leu Ile Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser 
        35                  40                  45              


Ala Asn Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys 
    50                  55                  60                  


Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr 
65                  70                  75                  80  


Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val 
                85                  90                  95      


Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro 
            100                 105                 110         


Cys Asn Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu 
        115                 120                 125             


Leu Glu Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile 
    130                 135                 140                 


<210>  126
<211>  144
<212>  PRT
<213>  Mus musculus

<400>  126

Met Leu Val Thr Tyr Ile Leu Ala Ser Val Leu Leu Phe Ser Ser Val 
1               5                   10                  15      


Leu Gly Gln Arg Cys Ser Thr Thr Trp Gly Ile Arg Asp Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Asn Leu Lys Asp Asp Pro Pro Ser Lys Cys Ser Cys Ser 
        35                  40                  45              


Gly Asn Val Thr Ser Cys Leu Cys Leu Ser Val Pro Thr Asp Asp Cys 
    50                  55                  60                  


Thr Thr Pro Cys Tyr Arg Glu Gly Leu Leu Gln Leu Thr Asn Ala Thr 
65                  70                  75                  80  


Gln Lys Ser Arg Leu Leu Pro Val Phe His Arg Val Lys Arg Ile Val 
                85                  90                  95      


Glu Val Leu Lys Asn Ile Thr Cys Pro Ser Phe Ser Cys Glu Lys Pro 
            100                 105                 110         


Cys Asn Gln Thr Met Ala Gly Asn Thr Leu Ser Phe Leu Lys Ser Leu 
        115                 120                 125             


Leu Gly Thr Phe Gln Lys Thr Glu Met Gln Arg Gln Lys Ser Arg Pro 
    130                 135                 140                 


<210>  127
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  127

Met His Pro Leu Leu Asn Pro Leu Leu Leu Ala Leu Gly Leu Met Ala 
1               5                   10                  15      


Leu Leu Leu Thr Thr Val Ile Ala Leu Thr Cys Leu Gly Gly Phe Ala 
            20                  25                  30          


Ser Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Arg Glu Leu Ile Glu 
        35                  40                  45              


Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly 
    50                  55                  60                  


Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala 
65                  70                  75                  80  


Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr 
                85                  90                  95      


Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln 
            100                 105                 110         


Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile Glu Val Ala Gln Phe 
        115                 120                 125             


Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Arg Glu Gly Arg 
    130                 135                 140                 


Phe Asn 
145     


<210>  128
<211>  131
<212>  PRT
<213>  Mus musculus

<400>  128

Met Ala Leu Trp Val Thr Ala Val Leu Ala Leu Ala Cys Leu Gly Gly 
1               5                   10                  15      


Leu Ala Ala Pro Gly Pro Val Pro Arg Ser Val Ser Leu Pro Leu Thr 
            20                  25                  30          


Leu Lys Glu Leu Ile Glu Glu Leu Ser Asn Ile Thr Gln Asp Gln Thr 
        35                  40                  45              


Pro Leu Cys Asn Gly Ser Met Val Trp Ser Val Asp Leu Ala Ala Gly 
    50                  55                  60                  


Gly Phe Cys Val Ala Leu Asp Ser Leu Thr Asn Ile Ser Asn Cys Asn 
65                  70                  75                  80  


Ala Ile Tyr Arg Thr Gln Arg Ile Leu His Gly Leu Cys Asn Arg Lys 
                85                  90                  95      


Ala Pro Thr Thr Val Ser Ser Leu Pro Asp Thr Lys Ile Glu Val Ala 
            100                 105                 110         


His Phe Ile Thr Lys Leu Leu Ser Tyr Thr Lys Gln Leu Phe Arg His 
        115                 120                 125             


Gly Pro Phe 
    130     


<210>  129
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  129

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210>  130
<211>  162
<212>  PRT
<213>  Mus musculus

<400>  130

Met Lys Ile Leu Lys Pro Tyr Met Arg Asn Thr Ser Ile Ser Cys Tyr 
1               5                   10                  15      


Leu Cys Phe Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Val Ser Val Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Ile Asp Val Arg Tyr Asp Leu Glu Lys Ile Glu Ser Leu Ile 
    50                  55                  60                  


Gln Ser Ile His Ile Asp Thr Thr Leu Tyr Thr Asp Ser Asp Phe His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Asn Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Leu His Glu Tyr Ser Asn Met Thr Leu Asn Glu Thr Val Arg 
            100                 105                 110         


Asn Val Leu Tyr Leu Ala Asn Ser Thr Leu Ser Ser Asn Lys Asn Val 
        115                 120                 125             


Ala Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Thr Phe 
    130                 135                 140                 


Thr Glu Phe Leu Gln Ser Phe Ile Arg Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210>  131
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  131

Met Ser Arg Leu Pro Val Leu Leu Leu Leu Gln Leu Leu Val Arg Pro 
1               5                   10                  15      


Gly Leu Gln Ala Pro Met Thr Gln Thr Thr Pro Leu Lys Thr Ser Trp 
            20                  25                  30          


Val Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln 
        35                  40                  45              


Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln 
    50                  55                  60                  


Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe 
65                  70                  75                  80  


Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile 
                85                  90                  95      


Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr 
            100                 105                 110         


Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg 
        115                 120                 125             


Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln 
    130                 135                 140                 


Thr Thr Leu Ser Leu Ala Ile Phe 
145                 150         


<210>  132
<211>  166
<212>  PRT
<213>  Mus musculus

<400>  132

Met Val Leu Ala Ser Ser Thr Thr Ser Ile His Thr Met Leu Leu Leu 
1               5                   10                  15      


Leu Leu Met Leu Phe His Leu Gly Leu Gln Ala Ser Ile Ser Gly Arg 
            20                  25                  30          


Asp Thr His Arg Leu Thr Arg Thr Leu Asn Cys Ser Ser Ile Val Lys 
        35                  40                  45              


Glu Ile Ile Gly Lys Leu Pro Glu Pro Glu Leu Lys Thr Asp Asp Glu 
    50                  55                  60                  


Gly Pro Ser Leu Arg Asn Lys Ser Phe Arg Arg Val Asn Leu Ser Lys 
65                  70                  75                  80  


Phe Val Glu Ser Gln Gly Glu Val Asp Pro Glu Asp Arg Tyr Val Ile 
                85                  90                  95      


Lys Ser Asn Leu Gln Lys Leu Asn Cys Cys Leu Pro Thr Ser Ala Asn 
            100                 105                 110         


Asp Ser Ala Leu Pro Gly Val Phe Ile Arg Asp Leu Asp Asp Phe Arg 
        115                 120                 125             


Lys Lys Leu Arg Phe Tyr Met Val His Leu Asn Asp Leu Glu Thr Val 
    130                 135                 140                 


Leu Thr Ser Arg Pro Pro Gln Pro Ala Ser Gly Ser Val Ser Pro Asn 
145                 150                 155                 160 


Arg Gly Thr Val Glu Cys 
                165     


<210>  133
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  133

Met Arg Met Leu Leu His Leu Ser Leu Leu Ala Leu Gly Ala Ala Tyr 
1               5                   10                  15      


Val Tyr Ala Ile Pro Thr Glu Ile Pro Thr Ser Ala Leu Val Lys Glu 
            20                  25                  30          


Thr Leu Ala Leu Leu Ser Thr His Arg Thr Leu Leu Ile Ala Asn Glu 
        35                  40                  45              


Thr Leu Arg Ile Pro Val Pro Val His Lys Asn His Gln Leu Cys Thr 
    50                  55                  60                  


Glu Glu Ile Phe Gln Gly Ile Gly Thr Leu Glu Ser Gln Thr Val Gln 
65                  70                  75                  80  


Gly Gly Thr Val Glu Arg Leu Phe Lys Asn Leu Ser Leu Ile Lys Lys 
                85                  90                  95      


Tyr Ile Asp Gly Gln Lys Lys Lys Cys Gly Glu Glu Arg Arg Arg Val 
            100                 105                 110         


Asn Gln Phe Leu Asp Tyr Leu Gln Glu Phe Leu Gly Val Met Asn Thr 
        115                 120                 125             


Glu Trp Ile Ile Glu Ser 
    130                 


<210>  134
<211>  133
<212>  PRT
<213>  Mus musculus

<400>  134

Met Arg Arg Met Leu Leu His Leu Ser Val Leu Thr Leu Ser Cys Val 
1               5                   10                  15      


Trp Ala Thr Ala Met Glu Ile Pro Met Ser Thr Val Val Lys Glu Thr 
            20                  25                  30          


Leu Thr Gln Leu Ser Ala His Arg Ala Leu Leu Thr Ser Asn Glu Thr 
        35                  40                  45              


Met Arg Leu Pro Val Pro Thr His Lys Asn His Gln Leu Cys Ile Gly 
    50                  55                  60                  


Glu Ile Phe Gln Gly Leu Asp Ile Leu Lys Asn Gln Thr Val Arg Gly 
65                  70                  75                  80  


Gly Thr Val Glu Met Leu Phe Gln Asn Leu Ser Leu Ile Lys Lys Tyr 
                85                  90                  95      


Ile Asp Arg Gln Lys Glu Lys Cys Gly Glu Glu Arg Arg Arg Thr Arg 
            100                 105                 110         


Gln Phe Leu Asp Tyr Leu Gln Glu Phe Leu Gly Val Met Ser Thr Glu 
        115                 120                 125             


Trp Ala Met Glu Gly 
    130             


<210>  135
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  135

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


<210>  136
<211>  141
<212>  PRT
<213>  Mus musculus

<400>  136

Met Trp Leu Gln Asn Leu Leu Phe Leu Gly Ile Val Val Tyr Ser Leu 
1               5                   10                  15      


Ser Ala Pro Thr Arg Ser Pro Ile Thr Val Thr Arg Pro Trp Lys His 
            20                  25                  30          


Val Glu Ala Ile Lys Glu Ala Leu Asn Leu Leu Asp Asp Met Pro Val 
        35                  40                  45              


Thr Leu Asn Glu Glu Val Glu Val Val Ser Asn Glu Phe Ser Phe Lys 
    50                  55                  60                  


Lys Leu Thr Cys Val Gln Thr Arg Leu Lys Ile Phe Glu Gln Gly Leu 
65                  70                  75                  80  


Arg Gly Asn Phe Thr Lys Leu Lys Gly Ala Leu Asn Met Thr Ala Ser 
                85                  90                  95      


Tyr Tyr Gln Thr Tyr Cys Pro Pro Thr Pro Glu Thr Asp Cys Glu Thr 
            100                 105                 110         


Gln Val Thr Thr Tyr Ala Asp Phe Ile Asp Ser Leu Lys Thr Phe Leu 
        115                 120                 125             


Thr Asp Ile Pro Phe Glu Cys Lys Lys Pro Gly Gln Lys 
    130                 135                 140     


<210>  137
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  137

Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 
145                 150                 155                 160 


Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met 
    210         


<210>  138
<211>  211
<212>  PRT
<213>  Mus musculus

<400>  138

Met Lys Phe Leu Ser Ala Arg Asp Phe His Pro Val Ala Phe Leu Gly 
1               5                   10                  15      


Leu Met Leu Val Thr Thr Thr Ala Phe Pro Thr Ser Gln Val Arg Arg 
            20                  25                  30          


Gly Asp Phe Thr Glu Asp Thr Thr Pro Asn Arg Pro Val Tyr Thr Thr 
        35                  40                  45              


Ser Gln Val Gly Gly Leu Ile Thr His Val Leu Trp Glu Ile Val Glu 
    50                  55                  60                  


Met Arg Lys Glu Leu Cys Asn Gly Asn Ser Asp Cys Met Asn Asn Asp 
65                  70                  75                  80  


Asp Ala Leu Ala Glu Asn Asn Leu Lys Leu Pro Glu Ile Gln Arg Asn 
                85                  90                  95      


Asp Gly Cys Tyr Gln Thr Gly Tyr Asn Gln Glu Ile Cys Leu Leu Lys 
            100                 105                 110         


Ile Ser Ser Gly Leu Leu Glu Tyr His Ser Tyr Leu Glu Tyr Met Lys 
        115                 120                 125             


Asn Asn Leu Lys Asp Asn Lys Lys Asp Lys Ala Arg Val Leu Gln Arg 
    130                 135                 140                 


Asp Thr Glu Thr Leu Ile His Ile Phe Asn Gln Glu Val Lys Asp Leu 
145                 150                 155                 160 


His Lys Ile Val Leu Pro Thr Pro Ile Ser Asn Ala Leu Leu Thr Asp 
                165                 170                 175     


Lys Leu Glu Ser Gln Lys Glu Trp Leu Arg Thr Lys Thr Ile Gln Phe 
            180                 185                 190         


Ile Leu Lys Ser Leu Glu Glu Phe Leu Lys Val Thr Leu Arg Ser Thr 
        195                 200                 205             


Arg Gln Thr 
    210     


<210>  139
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  139

Met Asn Cys Val Cys Arg Leu Val Leu Val Val Leu Ser Leu Trp Pro 
1               5                   10                  15      


Asp Thr Ala Val Ala Pro Gly Pro Pro Pro Gly Pro Pro Arg Val Ser 
            20                  25                  30          


Pro Asp Pro Arg Ala Glu Leu Asp Ser Thr Val Leu Leu Thr Arg Ser 
        35                  40                  45              


Leu Leu Ala Asp Thr Arg Gln Leu Ala Ala Gln Leu Arg Asp Lys Phe 
    50                  55                  60                  


Pro Ala Asp Gly Asp His Asn Leu Asp Ser Leu Pro Thr Leu Ala Met 
65                  70                  75                  80  


Ser Ala Gly Ala Leu Gly Ala Leu Gln Leu Pro Gly Val Leu Thr Arg 
                85                  90                  95      


Leu Arg Ala Asp Leu Leu Ser Tyr Leu Arg His Val Gln Trp Leu Arg 
            100                 105                 110         


Arg Ala Gly Gly Ser Ser Leu Lys Thr Leu Glu Pro Glu Leu Gly Thr 
        115                 120                 125             


Leu Gln Ala Arg Leu Asp Arg Leu Leu Arg Arg Leu Gln Leu Leu Met 
    130                 135                 140                 


Ser Arg Leu Ala Leu Pro Gln Pro Pro Pro Asp Pro Pro Ala Pro Pro 
145                 150                 155                 160 


Leu Ala Pro Pro Ser Ser Ala Trp Gly Gly Ile Arg Ala Ala His Ala 
                165                 170                 175     


Ile Leu Gly Gly Leu His Leu Thr Leu Asp Trp Ala Val Arg Gly Leu 
            180                 185                 190         


Leu Leu Leu Lys Thr Arg Leu 
        195                 


<210>  140
<211>  199
<212>  PRT
<213>  Mus musculus

<400>  140

Met Asn Cys Val Cys Arg Leu Val Leu Val Val Leu Ser Leu Trp Pro 
1               5                   10                  15      


Asp Arg Val Val Ala Pro Gly Pro Pro Ala Gly Ser Pro Arg Val Ser 
            20                  25                  30          


Ser Asp Pro Arg Ala Asp Leu Asp Ser Ala Val Leu Leu Thr Arg Ser 
        35                  40                  45              


Leu Leu Ala Asp Thr Arg Gln Leu Ala Ala Gln Met Arg Asp Lys Phe 
    50                  55                  60                  


Pro Ala Asp Gly Asp His Ser Leu Asp Ser Leu Pro Thr Leu Ala Met 
65                  70                  75                  80  


Ser Ala Gly Thr Leu Gly Ser Leu Gln Leu Pro Gly Val Leu Thr Arg 
                85                  90                  95      


Leu Arg Val Asp Leu Met Ser Tyr Leu Arg His Val Gln Trp Leu Arg 
            100                 105                 110         


Arg Ala Gly Gly Pro Ser Leu Lys Thr Leu Glu Pro Glu Leu Gly Ala 
        115                 120                 125             


Leu Gln Ala Arg Leu Glu Arg Leu Leu Arg Arg Leu Gln Leu Leu Met 
    130                 135                 140                 


Ser Arg Leu Ala Leu Pro Gln Ala Ala Pro Asp Gln Pro Val Ile Pro 
145                 150                 155                 160 


Leu Gly Pro Pro Ala Ser Ala Trp Gly Ser Ile Arg Ala Ala His Ala 
                165                 170                 175     


Ile Leu Gly Gly Leu His Leu Thr Leu Asp Trp Ala Val Arg Gly Leu 
            180                 185                 190         


Leu Leu Leu Lys Thr Arg Leu 
        195                 


<210>  141
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  141

Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro 
            20                  25                  30          


Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 
        35                  40                  45              


Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 
    50                  55                  60                  


Leu Val Ser Glu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 
65                  70                  75                  80  


Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 
                85                  90                  95      


Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 
            100                 105                 110         


Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 
        115                 120                 125             


Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 
    130                 135                 140                 


Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 
145                 150                 155                 160 


Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 
                165                 170                 175     


Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 
            180                 185                 190         


Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
        195                 200                 205         


<210>  142
<211>  208
<212>  PRT
<213>  Mus musculus

<400>  142

Met Ala Gln Leu Ser Ala Gln Arg Arg Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp Gln Ser Ala Leu Trp Ser Gly Arg Glu Ala Val Pro 
            20                  25                  30          


Leu Val Thr Val Ser Ala Leu Pro Pro Ser Leu Pro Leu Pro Arg Ser 
        35                  40                  45              


Phe Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Ala Ser Gly 
    50                  55                  60                  


Ser Val Leu Leu Glu Gln Leu Cys Ala Thr Tyr Lys Leu Cys His Pro 
65                  70                  75                  80  


Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Lys Ala Ser 
                85                  90                  95      


Leu Ser Gly Cys Ser Ser Gln Ala Leu Gln Gln Thr Gln Cys Leu Ser 
            100                 105                 110         


Gln Leu His Ser Gly Leu Cys Leu Tyr Gln Gly Leu Leu Gln Ala Leu 
        115                 120                 125             


Ser Gly Ile Ser Pro Ala Leu Ala Pro Thr Leu Asp Leu Leu Gln Leu 
    130                 135                 140                 


Asp Val Ala Asn Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Asn Leu 
145                 150                 155                 160 


Gly Val Ala Pro Thr Val Gln Pro Thr Gln Ser Ala Met Pro Ala Phe 
                165                 170                 175     


Thr Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Ala Ile Ser Tyr 
            180                 185                 190         


Leu Gln Gly Phe Leu Glu Thr Ala Arg Leu Ala Leu His His Leu Ala 
        195                 200                 205             


<210>  143
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  143

Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val Leu Leu 
1               5                   10                  15      


Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            20                  25                  30          


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        35                  40                  45              


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    50                  55                  60                  


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
65                  70                  75                  80  


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                85                  90                  95      


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            100                 105                 110         


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        115                 120                 125             


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    130                 135                 140                 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
145                 150                 155                 160 


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                165                 170                 175     


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            180                 185                 190         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        195                 200                 205             


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
    210                 215                 


<210>  144
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  144

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser 
                325             


<210>  145
<211>  335
<212>  PRT
<213>  Mus musculus

<400>  145

Met Cys Pro Gln Lys Leu Thr Ile Ser Trp Phe Ala Ile Val Leu Leu 
1               5                   10                  15      


Val Ser Pro Leu Met Ala Met Trp Glu Leu Glu Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln 
    50                  55                  60                  


Arg His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys 
65                  70                  75                  80  


Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr 
                85                  90                  95      


Leu Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp 
            100                 105                 110         


Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys 
        115                 120                 125             


Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln 
    130                 135                 140                 


Arg Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro 
145                 150                 155                 160 


Asp Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys 
                165                 170                 175     


Val Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln 
            180                 185                 190         


Glu Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu 
        195                 200                 205             


Ala Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser 
    210                 215                 220                 


Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln 
225                 230                 235                 240 


Met Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro 
                245                 250                 255     


Asp Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val 
            260                 265                 270         


Arg Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys 
        275                 280                 285             


Asn Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln 
    290                 295                 300                 


Cys Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn 
305                 310                 315                 320 


Ser Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser 
                325                 330                 335 


<210>  146
<211>  215
<212>  PRT
<213>  Mus musculus

<400>  146

Met Cys Gln Ser Arg Tyr Leu Leu Phe Leu Ala Thr Leu Ala Leu Leu 
1               5                   10                  15      


Asn His Leu Ser Leu Ala Arg Val Ile Pro Val Ser Gly Pro Ala Arg 
            20                  25                  30          


Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp Met Val 
        35                  40                  45              


Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala Glu Asp 
    50                  55                  60                  


Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr 
65                  70                  75                  80  


Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala Thr Arg 
                85                  90                  95      


Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr 
            100                 105                 110         


Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys 
        115                 120                 125             


Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln Asn His 
    130                 135                 140                 


Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala Ile Asp 
145                 150                 155                 160 


Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg Gln Lys 
                165                 170                 175     


Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys Leu Cys 
            180                 185                 190         


Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn Arg Val 
        195                 200                 205             


Met Gly Tyr Leu Ser Ser Ala 
    210                 215 


<210>  147
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  147

Met Lys Val Leu Ala Ala Gly Val Val Pro Leu Leu Leu Val Leu His 
1               5                   10                  15      


Trp Lys His Gly Ala Gly Ser Pro Leu Pro Ile Thr Pro Val Asn Ala 
            20                  25                  30          


Thr Cys Ala Ile Arg His Pro Cys His Asn Asn Leu Met Asn Gln Ile 
        35                  40                  45              


Arg Ser Gln Leu Ala Gln Leu Asn Gly Ser Ala Asn Ala Leu Phe Ile 
    50                  55                  60                  


Leu Tyr Tyr Thr Ala Gln Gly Glu Pro Phe Pro Asn Asn Leu Asp Lys 
65                  70                  75                  80  


Leu Cys Gly Pro Asn Val Thr Asp Phe Pro Pro Phe His Ala Asn Gly 
                85                  90                  95      


Thr Glu Lys Ala Lys Leu Val Glu Leu Tyr Arg Ile Val Val Tyr Leu 
            100                 105                 110         


Gly Thr Ser Leu Gly Asn Ile Thr Arg Asp Gln Lys Ile Leu Asn Pro 
        115                 120                 125             


Ser Ala Leu Ser Leu His Ser Lys Leu Asn Ala Thr Ala Asp Ile Leu 
    130                 135                 140                 


Arg Gly Leu Leu Ser Asn Val Leu Cys Arg Leu Cys Ser Lys Tyr His 
145                 150                 155                 160 


Val Gly His Val Asp Val Thr Tyr Gly Pro Asp Thr Ser Gly Lys Asp 
                165                 170                 175     


Val Phe Gln Lys Lys Lys Leu Gly Cys Gln Leu Leu Gly Lys Tyr Lys 
            180                 185                 190         


Gln Ile Ile Ala Val Leu Ala Gln Ala Phe 
        195                 200         


<210>  148
<211>  203
<212>  PRT
<213>  Mus musculus

<400>  148

Met Lys Val Leu Ala Ala Gly Ile Val Pro Leu Leu Leu Leu Val Leu 
1               5                   10                  15      


His Trp Lys His Gly Ala Gly Ser Pro Leu Pro Ile Thr Pro Val Asn 
            20                  25                  30          


Ala Thr Cys Ala Ile Arg His Pro Cys His Gly Asn Leu Met Asn Gln 
        35                  40                  45              


Ile Lys Asn Gln Leu Ala Gln Leu Asn Gly Ser Ala Asn Ala Leu Phe 
    50                  55                  60                  


Ile Ser Tyr Tyr Thr Ala Gln Gly Glu Pro Phe Pro Asn Asn Val Glu 
65                  70                  75                  80  


Lys Leu Cys Ala Pro Asn Met Thr Asp Phe Pro Ser Phe His Gly Asn 
                85                  90                  95      


Gly Thr Glu Lys Thr Lys Leu Val Glu Leu Tyr Arg Met Val Ala Tyr 
            100                 105                 110         


Leu Ser Ala Ser Leu Thr Asn Ile Thr Arg Asp Gln Lys Val Leu Asn 
        115                 120                 125             


Pro Thr Ala Val Ser Leu Gln Val Lys Leu Asn Ala Thr Ile Asp Val 
    130                 135                 140                 


Met Arg Gly Leu Leu Ser Asn Val Leu Cys Arg Leu Cys Asn Lys Tyr 
145                 150                 155                 160 


Arg Val Gly His Val Asp Val Pro Pro Val Pro Asp His Ser Asp Lys 
                165                 170                 175     


Glu Ala Phe Gln Arg Lys Lys Leu Gly Cys Gln Leu Leu Gly Thr Tyr 
            180                 185                 190         


Lys Gln Val Ile Ser Val Val Val Gln Ala Phe 
        195                 200             


<210>  149
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  149

Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala 
1               5                   10                  15      


Leu Leu Phe Pro Ser Met Ala Ser Met Ala Ala Ile Gly Ser Cys Ser 
            20                  25                  30          


Lys Glu Tyr Arg Val Leu Leu Gly Gln Leu Gln Lys Gln Thr Asp Leu 
        35                  40                  45              


Met Gln Asp Thr Ser Arg Leu Leu Asp Pro Tyr Ile Arg Ile Gln Gly 
    50                  55                  60                  


Leu Asp Val Pro Lys Leu Arg Glu His Cys Arg Glu Arg Pro Gly Ala 
65                  70                  75                  80  


Phe Pro Ser Glu Glu Thr Leu Arg Gly Leu Gly Arg Arg Gly Phe Leu 
                85                  90                  95      


Gln Thr Leu Asn Ala Thr Leu Gly Cys Val Leu His Arg Leu Ala Asp 
            100                 105                 110         


Leu Glu Gln Arg Leu Pro Lys Ala Gln Asp Leu Glu Arg Ser Gly Leu 
        115                 120                 125             


Asn Ile Glu Asp Leu Glu Lys Leu Gln Met Ala Arg Pro Asn Ile Leu 
    130                 135                 140                 


Gly Leu Arg Asn Asn Ile Tyr Cys Met Ala Gln Leu Leu Asp Asn Ser 
145                 150                 155                 160 


Asp Thr Ala Glu Pro Thr Lys Ala Gly Arg Gly Ala Ser Gln Pro Pro 
                165                 170                 175     


Thr Pro Thr Pro Ala Ser Asp Ala Phe Gln Arg Lys Leu Glu Gly Cys 
            180                 185                 190         


Arg Phe Leu His Gly Tyr His Arg Phe Met His Ser Val Gly Arg Val 
        195                 200                 205             


Phe Ser Lys Trp Gly Glu Ser Pro Asn Arg Ser Arg Arg His Ser Pro 
    210                 215                 220                 


His Gln Ala Leu Arg Lys Gly Val Arg Arg Thr Arg Pro Ser Arg Lys 
225                 230                 235                 240 


Gly Lys Arg Leu Met Thr Arg Gly Gln Leu Pro Arg 
                245                 250         


<210>  150
<211>  263
<212>  PRT
<213>  Mus musculus

<400>  150

Met Gln Thr Arg Leu Leu Arg Thr Leu Leu Ser Leu Thr Leu Ser Leu 
1               5                   10                  15      


Leu Ile Leu Ser Met Ala Leu Ala Asn Arg Gly Cys Ser Asn Ser Ser 
            20                  25                  30          


Ser Gln Leu Leu Ser Gln Leu Gln Asn Gln Ala Asn Leu Thr Gly Asn 
        35                  40                  45              


Thr Glu Ser Leu Leu Glu Pro Tyr Ile Arg Leu Gln Asn Leu Asn Thr 
    50                  55                  60                  


Pro Asp Leu Arg Ala Ala Cys Thr Gln His Ser Val Ala Phe Pro Ser 
65                  70                  75                  80  


Glu Asp Thr Leu Arg Gln Leu Ser Lys Pro His Phe Leu Ser Thr Val 
                85                  90                  95      


Tyr Thr Thr Leu Asp Arg Val Leu Tyr Gln Leu Asp Ala Leu Arg Gln 
            100                 105                 110         


Lys Phe Leu Lys Thr Pro Ala Phe Pro Lys Leu Asp Ser Ala Arg His 
        115                 120                 125             


Asn Ile Leu Gly Ile Arg Asn Asn Val Phe Cys Met Ala Arg Leu Leu 
    130                 135                 140                 


Asn His Ser Leu Glu Ile Pro Glu Pro Thr Gln Thr Asp Ser Gly Ala 
145                 150                 155                 160 


Ser Arg Ser Thr Thr Thr Pro Asp Val Phe Asn Thr Lys Ile Gly Ser 
                165                 170                 175     


Cys Gly Phe Leu Trp Gly Tyr His Arg Phe Met Gly Ser Val Gly Arg 
            180                 185                 190         


Val Phe Arg Glu Trp Asp Asp Gly Ser Thr Arg Ser Arg Arg Gln Ser 
        195                 200                 205             


Pro Leu Arg Ala Arg Arg Lys Gly Thr Arg Arg Ile Arg Val Arg His 
    210                 215                 220                 


Lys Gly Thr Arg Arg Ile Arg Val Arg Arg Lys Gly Thr Arg Arg Ile 
225                 230                 235                 240 


Trp Val Arg Arg Lys Gly Ser Arg Lys Ile Arg Pro Ser Arg Ser Thr 
                245                 250                 255     


Gln Ser Pro Thr Thr Arg Ala 
            260             


<210>  151
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  151

Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210>  152
<211>  178
<212>  PRT
<213>  Mus musculus

<400>  152

Met Pro Gly Ser Ala Leu Leu Cys Cys Leu Leu Leu Leu Thr Gly Met 
1               5                   10                  15      


Arg Ile Ser Arg Gly Gln Tyr Ser Arg Glu Asp Asn Asn Cys Thr His 
            20                  25                  30          


Phe Pro Val Gly Gln Ser His Met Leu Leu Glu Leu Arg Thr Ala Phe 
        35                  40                  45              


Ser Gln Val Lys Thr Phe Phe Gln Thr Lys Asp Gln Leu Asp Asn Ile 
    50                  55                  60                  


Leu Leu Thr Asp Ser Leu Met Gln Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Val Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Lys His Gly Pro Glu Ile Lys Glu His Leu Asn Ser Leu 
            100                 105                 110         


Gly Glu Lys Leu Lys Thr Leu Arg Met Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Ser 
    130                 135                 140                 


Asp Phe Asn Lys Leu Gln Asp Gln Gly Val Tyr Lys Ala Met Asn Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Cys Ile Glu Ala Tyr Met Met Ile Lys Met 
                165                 170                 175     


Lys Ser 
        


<210>  153
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  153

Met Lys Ala Ser Ser Leu Ala Phe Ser Leu Leu Ser Ala Ala Phe Tyr 
1               5                   10                  15      


Leu Leu Trp Thr Pro Ser Thr Gly Leu Lys Thr Leu Asn Leu Gly Ser 
            20                  25                  30          


Cys Val Ile Ala Thr Asn Leu Gln Glu Ile Arg Asn Gly Phe Ser Glu 
        35                  40                  45              


Ile Arg Gly Ser Val Gln Ala Lys Asp Gly Asn Ile Asp Ile Arg Ile 
    50                  55                  60                  


Leu Arg Arg Thr Glu Ser Leu Gln Asp Thr Lys Pro Ala Asn Arg Cys 
65                  70                  75                  80  


Cys Leu Leu Arg His Leu Leu Arg Leu Tyr Leu Asp Arg Val Phe Lys 
                85                  90                  95      


Asn Tyr Gln Thr Pro Asp His Tyr Thr Leu Arg Lys Ile Ser Ser Leu 
            100                 105                 110         


Ala Asn Ser Phe Leu Thr Ile Lys Lys Asp Leu Arg Leu Cys His Ala 
        115                 120                 125             


His Met Thr Cys His Cys Gly Glu Glu Ala Met Lys Lys Tyr Ser Gln 
    130                 135                 140                 


Ile Leu Ser His Phe Glu Lys Leu Glu Pro Gln Ala Ala Val Val Lys 
145                 150                 155                 160 


Ala Leu Gly Glu Leu Asp Ile Leu Leu Gln Trp Met Glu Glu Thr Glu 
                165                 170                 175     


<210>  154
<211>  176
<212>  PRT
<213>  Mus musculus

<400>  154

Met Lys Gly Phe Gly Leu Ala Phe Gly Leu Phe Ser Ala Val Gly Phe 
1               5                   10                  15      


Leu Leu Trp Thr Pro Leu Thr Gly Leu Lys Thr Leu His Leu Gly Ser 
            20                  25                  30          


Cys Val Ile Thr Ala Asn Leu Gln Ala Ile Gln Lys Glu Phe Ser Glu 
        35                  40                  45              


Ile Arg Asp Ser Val Gln Ala Glu Asp Thr Asn Ile Asp Ile Arg Ile 
    50                  55                  60                  


Leu Arg Thr Thr Glu Ser Leu Lys Asp Ile Lys Ser Leu Asp Arg Cys 
65                  70                  75                  80  


Cys Phe Leu Arg His Leu Val Arg Phe Tyr Leu Asp Arg Val Phe Lys 
                85                  90                  95      


Val Tyr Gln Thr Pro Asp His His Thr Leu Arg Lys Ile Ser Ser Leu 
            100                 105                 110         


Ala Asn Ser Phe Leu Ile Ile Lys Lys Asp Leu Ser Val Cys His Ser 
        115                 120                 125             


His Met Ala Cys His Cys Gly Glu Glu Ala Met Glu Lys Tyr Asn Gln 
    130                 135                 140                 


Ile Leu Ser His Phe Ile Glu Leu Glu Leu Gln Ala Ala Val Val Lys 
145                 150                 155                 160 


Ala Leu Gly Glu Leu Gly Ile Leu Leu Arg Trp Met Glu Glu Met Leu 
                165                 170                 175     


<210>  155
<211>  546
<212>  PRT
<213>  Homo sapiens

<400>  155

Met Lys Asn Gln Asp Lys Lys Asn Gly Ala Ala Lys Gln Ser Asn Pro 
1               5                   10                  15      


Lys Ser Ser Pro Gly Gln Pro Glu Ala Gly Pro Glu Gly Ala Gln Glu 
            20                  25                  30          


Arg Pro Ser Gln Ala Ala Pro Ala Val Glu Ala Glu Gly Pro Gly Ser 
        35                  40                  45              


Ser Gln Ala Pro Arg Lys Pro Glu Gly Ala Gln Ala Arg Thr Ala Gln 
    50                  55                  60                  


Ser Gly Ala Leu Arg Asp Val Ser Glu Glu Leu Ser Arg Gln Leu Glu 
65                  70                  75                  80  


Asp Ile Leu Ser Thr Tyr Cys Val Asp Asn Asn Gln Gly Gly Pro Gly 
                85                  90                  95      


Glu Asp Gly Ala Gln Gly Glu Pro Ala Glu Pro Glu Asp Ala Glu Lys 
            100                 105                 110         


Ser Arg Thr Tyr Val Ala Arg Asn Gly Glu Pro Glu Pro Thr Pro Val 
        115                 120                 125             


Val Asn Gly Glu Lys Glu Pro Ser Lys Gly Asp Pro Asn Thr Glu Glu 
    130                 135                 140                 


Ile Arg Gln Ser Asp Glu Val Gly Asp Arg Asp His Arg Arg Pro Gln 
145                 150                 155                 160 


Glu Lys Lys Lys Ala Lys Gly Leu Gly Lys Glu Ile Thr Leu Leu Met 
                165                 170                 175     


Gln Thr Leu Asn Thr Leu Ser Thr Pro Glu Glu Lys Leu Ala Ala Leu 
            180                 185                 190         


Cys Lys Lys Tyr Ala Glu Leu Leu Glu Glu His Arg Asn Ser Gln Lys 
        195                 200                 205             


Gln Met Lys Leu Leu Gln Lys Lys Gln Ser Gln Leu Val Gln Glu Lys 
    210                 215                 220                 


Asp His Leu Arg Gly Glu His Ser Lys Ala Val Leu Ala Arg Ser Lys 
225                 230                 235                 240 


Leu Glu Ser Leu Cys Arg Glu Leu Gln Arg His Asn Arg Ser Leu Lys 
                245                 250                 255     


Glu Glu Gly Val Gln Arg Ala Arg Glu Glu Glu Glu Lys Arg Lys Glu 
            260                 265                 270         


Val Thr Ser His Phe Gln Val Thr Leu Asn Asp Ile Gln Leu Gln Met 
        275                 280                 285             


Glu Gln His Asn Glu Arg Asn Ser Lys Leu Arg Gln Glu Asn Met Glu 
    290                 295                 300                 


Leu Ala Glu Arg Leu Lys Lys Leu Ile Glu Gln Tyr Glu Leu Arg Glu 
305                 310                 315                 320 


Glu His Ile Asp Lys Val Phe Lys His Lys Asp Leu Gln Gln Gln Leu 
                325                 330                 335     


Val Asp Ala Lys Leu Gln Gln Ala Gln Glu Met Leu Lys Glu Ala Glu 
            340                 345                 350         


Glu Arg His Gln Arg Glu Lys Asp Phe Leu Leu Lys Glu Ala Val Glu 
        355                 360                 365             


Ser Gln Arg Met Cys Glu Leu Met Lys Gln Gln Glu Thr His Leu Lys 
    370                 375                 380                 


Gln Gln Leu Ala Leu Tyr Thr Glu Lys Phe Glu Glu Phe Gln Asn Thr 
385                 390                 395                 400 


Leu Ser Lys Ser Ser Glu Val Phe Thr Thr Phe Lys Gln Glu Met Glu 
                405                 410                 415     


Lys Met Thr Lys Lys Ile Lys Lys Leu Glu Lys Glu Thr Thr Met Tyr 
            420                 425                 430         


Arg Ser Arg Trp Glu Ser Ser Asn Lys Ala Leu Leu Glu Met Ala Glu 
        435                 440                 445             


Glu Lys Thr Val Arg Asp Lys Glu Leu Glu Gly Leu Gln Val Lys Ile 
    450                 455                 460                 


Gln Arg Leu Glu Lys Leu Cys Arg Ala Leu Gln Thr Glu Arg Asn Asp 
465                 470                 475                 480 


Leu Asn Lys Arg Val Gln Asp Leu Ser Ala Gly Gly Gln Gly Ser Leu 
                485                 490                 495     


Thr Asp Ser Gly Pro Glu Arg Arg Pro Glu Gly Pro Gly Ala Gln Ala 
            500                 505                 510         


Pro Ser Ser Pro Arg Val Thr Glu Ala Pro Cys Tyr Pro Gly Ala Pro 
        515                 520                 525             


Ser Thr Glu Ala Ser Gly Gln Thr Gly Pro Gln Glu Pro Thr Ser Ala 
    530                 535                 540                 


Arg Ala 
545     


<210>  156
<211>  554
<212>  PRT
<213>  Mus musculus

<400>  156

Met Lys Asn Gln Asp Lys Lys Asn Gly Pro Ala Lys His Ser Asn Ser 
1               5                   10                  15      


Lys Gly Ser Pro Gly Gln Arg Glu Ala Gly Pro Glu Gly Ala His Gly 
            20                  25                  30          


Arg Pro Arg Gln Thr Ala Pro Gly Ala Glu Ala Glu Gly Ser Thr Ser 
        35                  40                  45              


Gln Ala Pro Gly Lys Thr Glu Gly Ala Arg Ala Lys Ala Ala Gln Pro 
    50                  55                  60                  


Gly Ala Leu Cys Asp Val Ser Glu Glu Leu Ser Arg Gln Leu Glu Asp 
65                  70                  75                  80  


Ile Leu Ser Thr Tyr Cys Val Asp Asn Asn Gln Gly Gly Pro Ala Glu 
                85                  90                  95      


Glu Gly Ala Gln Gly Glu Pro Thr Glu Pro Glu Asp Thr Glu Lys Ser 
            100                 105                 110         


Arg Thr Tyr Ala Ala Arg Asn Gly Glu Pro Glu Pro Gly Ile Pro Val 
        115                 120                 125             


Val Asn Gly Glu Lys Glu Thr Ser Lys Gly Glu Pro Gly Thr Glu Glu 
    130                 135                 140                 


Ile Arg Ala Ser Asp Glu Val Gly Asp Arg Asp His Arg Arg Pro Gln 
145                 150                 155                 160 


Glu Lys Lys Lys Ala Lys Gly Leu Gly Lys Glu Ile Thr Leu Leu Met 
                165                 170                 175     


Gln Thr Leu Asn Thr Leu Ser Thr Pro Glu Glu Lys Leu Ala Ala Leu 
            180                 185                 190         


Cys Lys Lys Tyr Ala Glu Leu Leu Glu Glu His Arg Asn Ser Gln Lys 
        195                 200                 205             


Gln Met Lys Leu Leu Gln Lys Lys Gln Ser Gln Leu Val Gln Glu Lys 
    210                 215                 220                 


Asp His Leu Arg Gly Glu His Ser Lys Ala Val Leu Ala Arg Ser Lys 
225                 230                 235                 240 


Leu Glu Ser Leu Cys Arg Glu Leu Gln Arg His Asn Arg Ser Leu Lys 
                245                 250                 255     


Glu Glu Gly Val Gln Arg Ala Arg Glu Glu Glu Glu Lys Arg Lys Glu 
            260                 265                 270         


Val Thr Ser His Phe Gln Val Thr Leu Asn Asp Ile Gln Leu Gln Met 
        275                 280                 285             


Glu Gln His Asn Glu Arg Asn Ser Lys Leu Arg Gln Glu Asn Met Glu 
    290                 295                 300                 


Leu Ala Glu Arg Leu Lys Lys Leu Ile Glu Gln Tyr Glu Leu Arg Glu 
305                 310                 315                 320 


Glu His Ile Asp Lys Val Phe Lys His Lys Asp Leu Gln Gln Gln Leu 
                325                 330                 335     


Val Asp Ala Lys Leu Gln Gln Ala Gln Glu Met Leu Lys Glu Ala Glu 
            340                 345                 350         


Glu Arg His Gln Arg Glu Lys Glu Phe Leu Leu Lys Glu Ala Val Glu 
        355                 360                 365             


Ser Gln Arg Met Cys Glu Leu Met Lys Gln Gln Glu Thr His Leu Lys 
    370                 375                 380                 


Gln Gln Leu Ala Leu Tyr Thr Glu Lys Phe Glu Glu Phe Gln Asn Thr 
385                 390                 395                 400 


Leu Ser Lys Ser Ser Glu Val Phe Thr Thr Phe Lys Gln Glu Met Glu 
                405                 410                 415     


Lys Met Thr Lys Lys Ile Lys Lys Leu Glu Lys Glu Thr Thr Met Tyr 
            420                 425                 430         


Arg Ser Arg Trp Glu Ser Ser Asn Lys Ala Leu Leu Glu Met Ala Glu 
        435                 440                 445             


Glu Lys Thr Val Arg Asp Lys Glu Leu Glu Gly Leu Gln Val Lys Ile 
    450                 455                 460                 


Gln Arg Leu Glu Lys Leu Cys Arg Ala Leu Gln Thr Glu Arg Asn Asp 
465                 470                 475                 480 


Leu Asn Lys Arg Val Gln Asp Leu Thr Ala Gly Gly Ile Thr Asp Ile 
                485                 490                 495     


Gly Ser Glu Arg Arg Pro Glu Ala Thr Thr Ala Ser Lys Glu Gln Gly 
            500                 505                 510         


Val Glu Ser Pro Gly Ala Gln Pro Ala Ser Ser Pro Arg Ala Thr Asp 
        515                 520                 525             


Ala Pro Cys Cys Ser Gly Ala Pro Ser Thr Gly Thr Ala Gly Gln Thr 
    530                 535                 540                 


Gly Pro Gly Glu Pro Thr Pro Ala Thr Ala 
545                 550                 


<210>  157
<211>  1331
<212>  PRT
<213>  Homo sapiens

<400>  157

Met Glu Ser His Ser Arg Ala Gly Lys Ser Arg Lys Ser Ala Lys Phe 
1               5                   10                  15      


Arg Ser Ile Ser Arg Ser Leu Met Leu Cys Asn Ala Lys Thr Ser Asp 
            20                  25                  30          


Asp Gly Ser Ser Pro Asp Glu Lys Tyr Pro Asp Pro Phe Glu Ile Ser 
        35                  40                  45              


Leu Ala Gln Gly Lys Glu Gly Ile Phe His Ser Ser Val Gln Leu Ala 
    50                  55                  60                  


Asp Thr Ser Glu Ala Gly Pro Ser Ser Val Pro Asp Leu Ala Leu Ala 
65                  70                  75                  80  


Ser Glu Ala Ala Gln Leu Gln Ala Ala Gly Asn Asp Arg Gly Lys Thr 
                85                  90                  95      


Cys Arg Arg Ile Phe Phe Met Lys Glu Ser Ser Thr Ala Ser Ser Arg 
            100                 105                 110         


Glu Lys Pro Gly Lys Leu Glu Ala Gln Ser Ser Asn Phe Leu Phe Pro 
        115                 120                 125             


Lys Ala Cys His Gln Arg Ala Arg Ser Asn Ser Thr Ser Val Asn Pro 
    130                 135                 140                 


Tyr Cys Thr Arg Glu Ile Asp Phe Pro Met Thr Lys Lys Ser Ala Ala 
145                 150                 155                 160 


Pro Thr Asp Arg Gln Pro Tyr Ser Leu Cys Ser Asn Arg Lys Ser Leu 
                165                 170                 175     


Ser Gln Gln Leu Asp Cys Pro Ala Gly Lys Ala Ala Gly Thr Ser Arg 
            180                 185                 190         


Pro Thr Arg Ser Leu Ser Thr Ala Gln Leu Val Gln Pro Ser Gly Gly 
        195                 200                 205             


Leu Gln Ala Ser Val Ile Ser Asn Ile Val Leu Met Lys Gly Gln Ala 
    210                 215                 220                 


Lys Gly Leu Gly Phe Ser Ile Val Gly Gly Lys Asp Ser Ile Tyr Gly 
225                 230                 235                 240 


Pro Ile Gly Ile Tyr Val Lys Thr Ile Phe Ala Gly Gly Ala Ala Ala 
                245                 250                 255     


Ala Asp Gly Arg Leu Gln Glu Gly Asp Glu Ile Leu Glu Leu Asn Gly 
            260                 265                 270         


Glu Ser Met Ala Gly Leu Thr His Gln Asp Ala Leu Gln Lys Phe Lys 
        275                 280                 285             


Gln Ala Lys Lys Gly Leu Leu Thr Leu Thr Val Arg Thr Arg Leu Thr 
    290                 295                 300                 


Ala Pro Pro Ser Leu Cys Ser His Leu Ser Pro Pro Leu Cys Arg Ser 
305                 310                 315                 320 


Leu Ser Ser Ser Thr Cys Ile Thr Lys Asp Ser Ser Ser Phe Ala Leu 
                325                 330                 335     


Glu Ser Pro Ser Ala Pro Ile Ser Thr Ala Lys Pro Asn Tyr Arg Ile 
            340                 345                 350         


Met Val Glu Val Ser Leu Gln Lys Glu Ala Gly Val Gly Leu Gly Ile 
        355                 360                 365             


Gly Leu Cys Ser Val Pro Tyr Phe Gln Cys Ile Ser Gly Ile Phe Val 
    370                 375                 380                 


His Thr Leu Ser Pro Gly Ser Val Ala His Leu Asp Gly Arg Leu Arg 
385                 390                 395                 400 


Cys Gly Asp Glu Ile Val Glu Ile Ser Asp Ser Pro Val His Cys Leu 
                405                 410                 415     


Thr Leu Asn Glu Val Tyr Thr Ile Leu Ser His Cys Asp Pro Gly Pro 
            420                 425                 430         


Val Pro Ile Ile Val Ser Arg His Pro Asp Pro Gln Val Ser Glu Gln 
        435                 440                 445             


Gln Leu Lys Glu Ala Val Ala Gln Ala Val Glu Asn Thr Lys Phe Gly 
    450                 455                 460                 


Lys Glu Arg His Gln Trp Ser Leu Glu Gly Val Lys Arg Leu Glu Ser 
465                 470                 475                 480 


Ser Trp His Gly Arg Pro Thr Leu Glu Lys Glu Arg Glu Lys Asn Ser 
                485                 490                 495     


Ala Pro Pro His Arg Arg Ala Gln Lys Val Met Ile Arg Ser Ser Ser 
            500                 505                 510         


Asp Ser Ser Tyr Met Ser Gly Ser Pro Gly Gly Ser Pro Gly Ser Gly 
        515                 520                 525             


Ser Ala Glu Lys Pro Ser Ser Asp Val Asp Ile Ser Thr His Ser Pro 
    530                 535                 540                 


Ser Leu Pro Leu Ala Arg Glu Pro Val Val Leu Ser Ile Ala Ser Ser 
545                 550                 555                 560 


Arg Leu Pro Gln Glu Ser Pro Pro Leu Pro Glu Ser Arg Asp Ser His 
                565                 570                 575     


Pro Pro Leu Arg Leu Lys Lys Ser Phe Glu Ile Val Arg Lys Pro Met 
            580                 585                 590         


Ser Ser Lys Pro Lys Pro Pro Pro Arg Lys Tyr Phe Lys Ser Asp Ser 
        595                 600                 605             


Asp Pro Gln Lys Ser Leu Glu Glu Arg Glu Asn Ser Ser Cys Ser Ser 
    610                 615                 620                 


Gly His Thr Pro Pro Thr Cys Gly Gln Glu Ala Arg Glu Leu Leu Pro 
625                 630                 635                 640 


Leu Leu Leu Pro Gln Glu Asp Thr Ala Gly Arg Ser Pro Ser Ala Ser 
                645                 650                 655     


Ala Gly Cys Pro Gly Pro Gly Ile Gly Pro Gln Thr Lys Ser Ser Thr 
            660                 665                 670         


Glu Gly Glu Pro Gly Trp Arg Arg Ala Ser Pro Val Thr Gln Thr Ser 
        675                 680                 685             


Pro Ile Lys His Pro Leu Leu Lys Arg Gln Ala Arg Met Asp Tyr Ser 
    690                 695                 700                 


Phe Asp Thr Thr Ala Glu Asp Pro Trp Val Arg Ile Ser Asp Cys Ile 
705                 710                 715                 720 


Lys Asn Leu Phe Ser Pro Ile Met Ser Glu Asn His Gly His Met Pro 
                725                 730                 735     


Leu Gln Pro Asn Ala Ser Leu Asn Glu Glu Glu Gly Thr Gln Gly His 
            740                 745                 750         


Pro Asp Gly Thr Pro Pro Lys Leu Asp Thr Ala Asn Gly Thr Pro Lys 
        755                 760                 765             


Val Tyr Lys Ser Ala Asp Ser Ser Thr Val Lys Lys Gly Pro Pro Val 
    770                 775                 780                 


Ala Pro Lys Pro Ala Trp Phe Arg Gln Ser Leu Lys Gly Leu Arg Asn 
785                 790                 795                 800 


Arg Ala Ser Asp Pro Arg Gly Leu Pro Asp Pro Ala Leu Ser Thr Gln 
                805                 810                 815     


Pro Ala Pro Ala Ser Arg Glu His Leu Gly Ser His Ile Arg Ala Ser 
            820                 825                 830         


Ser Ser Ser Ser Ser Ile Arg Gln Arg Ile Ser Ser Phe Glu Thr Phe 
        835                 840                 845             


Gly Ser Ser Gln Leu Pro Asp Lys Gly Ala Gln Arg Leu Ser Leu Gln 
    850                 855                 860                 


Pro Ser Ser Gly Glu Ala Ala Lys Pro Leu Gly Lys His Glu Glu Gly 
865                 870                 875                 880 


Arg Phe Ser Gly Leu Leu Gly Arg Gly Ala Ala Pro Thr Leu Val Pro 
                885                 890                 895     


Gln Gln Pro Glu Gln Val Leu Ser Ser Gly Ser Pro Ala Ala Ser Glu 
            900                 905                 910         


Ala Arg Asp Pro Gly Val Ser Glu Ser Pro Pro Pro Gly Arg Gln Pro 
        915                 920                 925             


Asn Gln Lys Thr Leu Pro Pro Gly Pro Asp Pro Leu Leu Arg Leu Leu 
    930                 935                 940                 


Ser Thr Gln Ala Glu Glu Ser Gln Gly Pro Val Leu Lys Met Pro Ser 
945                 950                 955                 960 


Gln Arg Ala Arg Ser Phe Pro Leu Thr Arg Ser Gln Ser Cys Glu Thr 
                965                 970                 975     


Lys Leu Leu Asp Glu Lys Thr Ser Lys Leu Tyr Ser Ile Ser Ser Gln 
            980                 985                 990         


Val Ser Ser Ala Val Met Lys Ser  Leu Leu Cys Leu Pro  Ser Ser Ile 
        995                 1000                 1005             


Ser Cys  Ala Gln Thr Pro Cys  Ile Pro Lys Glu Gly  Ala Ser Pro 
    1010                 1015                 1020             


Thr Ser  Ser Ser Asn Glu Asp  Ser Ala Ala Asn Gly  Ser Ala Glu 
    1025                 1030                 1035             


Thr Ser  Ala Leu Asp Thr Gly  Phe Ser Leu Asn Leu  Ser Glu Leu 
    1040                 1045                 1050             


Arg Glu  Tyr Thr Glu Gly Leu  Thr Glu Ala Lys Glu  Asp Asp Asp 
    1055                 1060                 1065             


Gly Asp  His Ser Ser Leu Gln  Ser Gly Gln Ser Val  Ile Ser Leu 
    1070                 1075                 1080             


Leu Ser  Ser Glu Glu Leu Lys  Lys Leu Ile Glu Glu  Val Lys Val 
    1085                 1090                 1095             


Leu Asp  Glu Ala Thr Leu Lys  Gln Leu Asp Gly Ile  His Val Thr 
    1100                 1105                 1110             


Ile Leu  His Lys Glu Glu Gly  Ala Gly Leu Gly Phe  Ser Leu Ala 
    1115                 1120                 1125             


Gly Gly  Ala Asp Leu Glu Asn  Lys Val Ile Thr Val  His Arg Val 
    1130                 1135                 1140             


Phe Pro  Asn Gly Leu Ala Ser  Gln Glu Gly Thr Ile  Gln Lys Gly 
    1145                 1150                 1155             


Asn Glu  Val Leu Ser Ile Asn  Gly Lys Ser Leu Lys  Gly Thr Thr 
    1160                 1165                 1170             


His His  Asp Ala Leu Ala Ile  Leu Arg Gln Ala Arg  Glu Pro Arg 
    1175                 1180                 1185             


Gln Ala  Val Ile Val Thr Arg  Lys Leu Thr Pro Glu  Ala Met Pro 
    1190                 1195                 1200             


Asp Leu  Asn Ser Ser Thr Asp  Ser Ala Ala Ser Ala  Ser Ala Ala 
    1205                 1210                 1215             


Ser Asp  Val Ser Val Glu Ser  Thr Ala Glu Ala Thr  Val Cys Thr 
    1220                 1225                 1230             


Val Thr  Leu Glu Lys Met Ser  Ala Gly Leu Gly Phe  Ser Leu Glu 
    1235                 1240                 1245             


Gly Gly  Lys Gly Ser Leu His  Gly Asp Lys Pro Leu  Thr Ile Asn 
    1250                 1255                 1260             


Arg Ile  Phe Lys Gly Ala Ala  Ser Glu Gln Ser Glu  Thr Val Gln 
    1265                 1270                 1275             


Pro Gly  Asp Glu Ile Leu Gln  Leu Gly Gly Thr Ala  Met Gln Gly 
    1280                 1285                 1290             


Leu Thr  Arg Phe Glu Ala Trp  Asn Ile Ile Lys Ala  Leu Pro Asp 
    1295                 1300                 1305             


Gly Pro  Val Thr Ile Val Ile  Arg Arg Lys Ser Leu  Gln Ser Lys 
    1310                 1315                 1320             


Glu Thr  Thr Ala Ala Gly Asp  Ser 
    1325                 1330     


<210>  158
<211>  1322
<212>  PRT
<213>  Mus musculus

<400>  158

Met Glu Pro His Gly His Ser Gly Lys Ser Arg Lys Ser Thr Lys Phe 
1               5                   10                  15      


Arg Ser Ile Ser Arg Ser Leu Ile Leu Cys Asn Ala Lys Thr Ser Asp 
            20                  25                  30          


Asp Gly Ser Ser Pro Asp Glu Lys Tyr Pro Asp Pro Phe Glu Thr Ser 
        35                  40                  45              


Leu Cys Gln Gly Lys Glu Gly Phe Phe His Ser Ser Met Gln Leu Ala 
    50                  55                  60                  


Asp Thr Phe Glu Ala Gly Leu Ser Asn Ile Pro Asp Leu Ala Leu Ala 
65                  70                  75                  80  


Ser Asp Ser Ala Gln Leu Ala Ala Ala Gly Ser Asp Arg Gly Lys His 
                85                  90                  95      


Cys Arg Lys Met Phe Phe Met Lys Glu Ser Ser Ser Thr Ser Ser Lys 
            100                 105                 110         


Glu Lys Ser Gly Lys Pro Glu Ala Gln Ser Ser Ser Phe Leu Phe Pro 
        115                 120                 125             


Lys Ala Cys His Gln Arg Thr Arg Ser Asn Ser Thr Ser Val Asn Pro 
    130                 135                 140                 


Tyr Ser Ala Gly Glu Ile Asp Phe Pro Met Thr Lys Lys Ser Ala Ala 
145                 150                 155                 160 


Pro Thr Asp Arg Gln Pro Tyr Ser Leu Cys Ser Asn Arg Lys Ser Leu 
                165                 170                 175     


Ser Gln Gln Leu Asp Tyr Pro Ile Leu Gly Thr Ala Arg Pro Thr Arg 
            180                 185                 190         


Ser Leu Ser Thr Ala Gln Leu Gly Gln Leu Ser Gly Gly Leu Gln Ala 
        195                 200                 205             


Ser Val Ile Ser Asn Ile Val Leu Met Lys Gly Gln Ala Lys Gly Leu 
    210                 215                 220                 


Gly Phe Ser Ile Val Gly Gly Lys Asp Ser Ile Tyr Gly Pro Ile Gly 
225                 230                 235                 240 


Ile Tyr Val Lys Ser Ile Phe Ala Gly Gly Ala Ala Ala Ala Asp Gly 
                245                 250                 255     


Arg Leu Gln Glu Gly Asp Glu Ile Leu Glu Leu Asn Gly Glu Ser Met 
            260                 265                 270         


Ala Gly Leu Thr His Gln Asp Ala Leu Gln Lys Phe Lys Gln Ala Lys 
        275                 280                 285             


Lys Gly Leu Leu Thr Leu Thr Val Arg Thr Arg Leu Thr Thr Pro Pro 
    290                 295                 300                 


Ser Leu Cys Ser His Leu Ser Pro Pro Leu Cys Arg Ser Leu Ser Ser 
305                 310                 315                 320 


Ser Thr Cys Gly Ala Gln Asp Ser Ser Pro Phe Ser Leu Glu Ser Pro 
                325                 330                 335     


Ala Ser Pro Ala Ser Thr Ala Lys Pro Asn Tyr Arg Ile Met Val Glu 
            340                 345                 350         


Val Ser Leu Lys Lys Glu Ala Gly Val Gly Leu Gly Ile Gly Leu Cys 
        355                 360                 365             


Ser Ile Pro Tyr Phe Gln Cys Ile Ser Gly Ile Phe Val His Thr Leu 
    370                 375                 380                 


Ser Pro Gly Ser Val Ala His Leu Asp Gly Arg Leu Arg Cys Gly Asp 
385                 390                 395                 400 


Glu Ile Val Glu Ile Asn Asp Ser Pro Val His Cys Leu Thr Leu Asn 
                405                 410                 415     


Glu Val Tyr Thr Ile Leu Ser His Cys Asp Pro Gly Pro Val Pro Ile 
            420                 425                 430         


Ile Val Ser Arg His Pro Asp Pro Gln Val Ser Glu Gln Gln Leu Lys 
        435                 440                 445             


Glu Ala Val Ala Gln Ala Val Glu Gly Val Lys Phe Gly Lys Asp Arg 
    450                 455                 460                 


His Gln Trp Ser Leu Glu Gly Val Lys Arg Leu Glu Ser Ser Trp His 
465                 470                 475                 480 


Gly Arg Pro Thr Leu Glu Lys Glu Arg Glu Lys His Ser Ala Pro Pro 
                485                 490                 495     


His Arg Arg Ala Gln Lys Ile Met Val Arg Ser Ser Ser Asp Ser Ser 
            500                 505                 510         


Tyr Met Ser Gly Ser Pro Gly Gly Ser Pro Cys Ser Ala Gly Ala Glu 
        515                 520                 525             


Pro Gln Pro Ser Glu Arg Glu Gly Ser Thr His Ser Pro Ser Leu Ser 
    530                 535                 540                 


Pro Gly Glu Glu Gln Glu Pro Cys Pro Gly Val Pro Ser Arg Pro Gln 
545                 550                 555                 560 


Gln Glu Ser Pro Pro Leu Pro Glu Ser Leu Glu Arg Glu Ser His Pro 
                565                 570                 575     


Pro Leu Arg Leu Lys Lys Ser Phe Glu Ile Leu Val Arg Lys Pro Thr 
            580                 585                 590         


Ser Ser Lys Pro Lys Pro Pro Pro Arg Lys Tyr Phe Lys Asn Asp Ser 
        595                 600                 605             


Glu Pro Gln Lys Lys Leu Glu Glu Lys Glu Lys Val Thr Asp Pro Ser 
    610                 615                 620                 


Gly His Thr Leu Pro Thr Cys Ser Gln Glu Thr Arg Glu Leu Leu Pro 
625                 630                 635                 640 


Leu Leu Leu Gln Glu Asp Thr Ala Gly Arg Ala Pro Cys Thr Ala Ala 
                645                 650                 655     


Cys Cys Pro Gly Pro Ala Ala Ser Thr Gln Thr Ser Ser Ser Thr Glu 
            660                 665                 670         


Gly Glu Ser Arg Arg Ser Ala Ser Pro Glu Thr Pro Ala Ser Pro Gly 
        675                 680                 685             


Lys His Pro Leu Leu Lys Arg Gln Ala Arg Met Asp Tyr Ser Phe Asp 
    690                 695                 700                 


Ile Thr Ala Glu Asp Pro Trp Val Arg Ile Ser Asp Cys Ile Lys Asn 
705                 710                 715                 720 


Leu Phe Ser Pro Ile Met Ser Glu Asn His Ser His Thr Pro Leu Gln 
                725                 730                 735     


Pro Asn Thr Ser Leu Gly Glu Glu Asp Gly Thr Gln Gly Cys Pro Glu 
            740                 745                 750         


Gly Gly Leu Ser Lys Met Asp Ala Ala Asn Gly Ala Pro Arg Val Tyr 
        755                 760                 765             


Lys Ser Ala Asp Gly Ser Thr Val Lys Lys Gly Pro Pro Val Ala Pro 
    770                 775                 780                 


Lys Pro Ala Trp Phe Arg Gln Ser Leu Lys Gly Leu Arg Asn Arg Ala 
785                 790                 795                 800 


Pro Asp Pro Arg Arg Pro Pro Glu Val Ala Ser Ala Ile Gln Pro Thr 
                805                 810                 815     


Pro Val Ser Arg Asp Pro Pro Gly Pro Gln Pro Gln Ala Ser Ser Ser 
            820                 825                 830         


Ile Arg Gln Arg Ile Ser Ser Phe Glu Asn Phe Gly Ser Ser Gln Leu 
        835                 840                 845             


Pro Asp Arg Gly Val Gln Arg Leu Ser Leu Gln Pro Ser Ser Gly Glu 
    850                 855                 860                 


Thr Thr Lys Phe Pro Gly Lys Gln Asp Gly Gly Arg Phe Ser Gly Leu 
865                 870                 875                 880 


Leu Gly Gln Gly Ala Thr Val Thr Ala Lys His Arg Gln Thr Glu Val 
                885                 890                 895     


Glu Ser Met Ser Thr Thr Phe Pro Asn Ser Ser Glu Val Arg Asp Pro 
            900                 905                 910         


Gly Leu Pro Glu Ser Pro Pro Pro Gly Gln Arg Pro Ser Thr Lys Ala 
        915                 920                 925             


Leu Ser Pro Asp Pro Leu Leu Arg Leu Leu Thr Thr Gln Ser Glu Asp 
    930                 935                 940                 


Thr Gln Gly Pro Gly Leu Lys Met Pro Ser Gln Arg Ala Arg Ser Phe 
945                 950                 955                 960 


Pro Leu Thr Arg Thr Gln Ser Cys Glu Thr Lys Leu Leu Asp Glu Lys 
                965                 970                 975     


Ala Ser Lys Leu Tyr Ser Ile Ser Ser Gln Leu Ser Ser Ala Val Met 
            980                 985                 990         


Lys Ser Leu Leu Cys Leu Pro Ser  Ser Val Ser Cys Gly  Gln Ile Thr 
        995                 1000                 1005             


Cys Ile  Pro Lys Glu Arg Val  Ser Pro Lys Ser Pro  Cys Asn Asn 
    1010                 1015                 1020             


Ser Ser  Ala Ala Glu Gly Phe  Gly Glu Ala Met Ala  Ser Asp Thr 
    1025                 1030                 1035             


Gly Phe  Ser Leu Asn Leu Ser  Glu Leu Arg Glu Tyr  Ser Glu Gly 
    1040                 1045                 1050             


Leu Thr  Glu Pro Gly Glu Thr  Glu Asp Arg Asn His  Cys Ser Ser 
    1055                 1060                 1065             


Gln Ala  Gly Gln Ser Val Ile  Ser Leu Leu Ser Ala  Glu Glu Leu 
    1070                 1075                 1080             


Glu Lys  Leu Ile Glu Glu Val  Arg Val Leu Asp Glu  Ala Thr Leu 
    1085                 1090                 1095             


Lys Gln  Leu Asp Ser Ile His  Val Thr Ile Leu His  Lys Glu Glu 
    1100                 1105                 1110             


Gly Ala  Gly Leu Gly Phe Ser  Leu Ala Gly Gly Ala  Asp Leu Glu 
    1115                 1120                 1125             


Asn Lys  Val Ile Thr Val His  Arg Val Phe Pro Asn  Gly Leu Ala 
    1130                 1135                 1140             


Ser Gln  Glu Gly Thr Ile Gln  Lys Gly Asn Glu Val  Leu Ser Ile 
    1145                 1150                 1155             


Asn Gly  Lys Ser Leu Lys Gly  Ala Thr His Asn Asp  Ala Leu Ala 
    1160                 1165                 1170             


Ile Leu  Arg Gln Ala Arg Asp  Pro Arg Gln Ala Val  Ile Val Thr 
    1175                 1180                 1185             


Arg Arg  Thr Thr Val Glu Ala  Thr His Asp Leu Asn  Ser Ser Thr 
    1190                 1195                 1200             


Asp Ser  Ala Ala Ser Ala Ser  Ala Ala Ser Asp Ile  Ser Val Glu 
    1205                 1210                 1215             


Ser Lys  Glu Ala Thr Val Cys  Thr Val Thr Leu Glu  Lys Thr Ser 
    1220                 1225                 1230             


Ala Gly  Leu Gly Phe Ser Leu  Glu Gly Gly Lys Gly  Ser Leu His 
    1235                 1240                 1245             


Gly Asp  Lys Pro Leu Thr Ile  Asn Arg Ile Phe Lys  Gly Thr Glu 
    1250                 1255                 1260             


Gln Gly  Glu Met Val Gln Pro  Gly Asp Glu Ile Leu  Gln Leu Ala 
    1265                 1270                 1275             


Gly Thr  Ala Val Gln Gly Leu  Thr Arg Phe Glu Ala  Trp Asn Val 
    1280                 1285                 1290             


Ile Lys  Ala Leu Pro Asp Gly  Pro Val Thr Ile Val  Ile Arg Arg 
    1295                 1300                 1305             


Thr Ser  Leu Gln Cys Lys Gln  Thr Thr Ala Ser Ala  Asp Ser 
    1310                 1315                 1320         


<210>  159
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  159

Met Thr Pro Gly Lys Thr Ser Leu Val Ser Leu Leu Leu Leu Leu Ser 
1               5                   10                  15      


Leu Glu Ala Ile Val Lys Ala Gly Ile Thr Ile Pro Arg Asn Pro Gly 
            20                  25                  30          


Cys Pro Asn Ser Glu Asp Lys Asn Phe Pro Arg Thr Val Met Val Asn 
        35                  40                  45              


Leu Asn Ile His Asn Arg Asn Thr Asn Thr Asn Pro Lys Arg Ser Ser 
    50                  55                  60                  


Asp Tyr Tyr Asn Arg Ser Thr Ser Pro Trp Asn Leu His Arg Asn Glu 
65                  70                  75                  80  


Asp Pro Glu Arg Tyr Pro Ser Val Ile Trp Glu Ala Lys Cys Arg His 
                85                  90                  95      


Leu Gly Cys Ile Asn Ala Asp Gly Asn Val Asp Tyr His Met Asn Ser 
            100                 105                 110         


Val Pro Ile Gln Gln Glu Ile Leu Val Leu Arg Arg Glu Pro Pro His 
        115                 120                 125             


Cys Pro Asn Ser Phe Arg Leu Glu Lys Ile Leu Val Ser Val Gly Cys 
    130                 135                 140                 


Thr Cys Val Thr Pro Ile Val His His Val Ala 
145                 150                 155 


<210>  160
<211>  158
<212>  PRT
<213>  Mus musculus

<400>  160

Met Ser Pro Gly Arg Ala Ser Ser Val Ser Leu Met Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ser Leu Ala Ala Thr Val Lys Ala Ala Ala Ile Ile Pro Gln Ser 
            20                  25                  30          


Ser Ala Cys Pro Asn Thr Glu Ala Lys Asp Phe Leu Gln Asn Val Lys 
        35                  40                  45              


Val Asn Leu Lys Val Phe Asn Ser Leu Gly Ala Lys Val Ser Ser Arg 
    50                  55                  60                  


Arg Pro Ser Asp Tyr Leu Asn Arg Ser Thr Ser Pro Trp Thr Leu His 
65                  70                  75                  80  


Arg Asn Glu Asp Pro Asp Arg Tyr Pro Ser Val Ile Trp Glu Ala Gln 
                85                  90                  95      


Cys Arg His Gln Arg Cys Val Asn Ala Glu Gly Lys Leu Asp His His 
            100                 105                 110         


Met Asn Ser Val Leu Ile Gln Gln Glu Ile Leu Val Leu Lys Arg Glu 
        115                 120                 125             


Pro Glu Ser Cys Pro Phe Thr Phe Arg Val Glu Lys Met Leu Val Gly 
    130                 135                 140                 


Val Gly Cys Thr Cys Val Ala Ser Ile Val Arg Gln Ala Ala 
145                 150                 155             


<210>  161
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  161

Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
                85                  90                  95      


Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu 
            100                 105                 110         


Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 
        115                 120                 125             


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
    130                 135                 140                 


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
145                 150                 155                 160 


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
                165                 170                 175     


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
            180                 185                 190         


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
        195                 200                 205             


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
    210                 215                 220                 


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
225                 230                 235                 240 


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
                245                 250                 255     


Gly Leu Leu Lys Leu 
            260     


<210>  162
<211>  260
<212>  PRT
<213>  Mus musculus

<400>  162

Met Ile Glu Thr Tyr Ser Gln Pro Ser Pro Arg Ser Val Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ala Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Val Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Val Glu Glu Glu Val Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Ile Lys Lys Leu Lys Arg Cys Asn Lys Gly Glu Gly Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Met Arg Arg Gln Phe Glu Asp Leu Val Lys 
                85                  90                  95      


Asp Ile Thr Leu Asn Lys Glu Glu Lys Lys Glu Asn Ser Phe Glu Met 
            100                 105                 110         


Gln Arg Gly Asp Glu Asp Pro Gln Ile Ala Ala His Val Val Ser Glu 
        115                 120                 125             


Ala Asn Ser Asn Ala Ala Ser Val Leu Gln Trp Ala Lys Lys Gly Tyr 
    130                 135                 140                 


Tyr Thr Met Lys Ser Asn Leu Val Met Leu Glu Asn Gly Lys Gln Leu 
145                 150                 155                 160 


Thr Val Lys Arg Glu Gly Leu Tyr Tyr Val Tyr Thr Gln Val Thr Phe 
                165                 170                 175     


Cys Ser Asn Arg Glu Pro Ser Ser Gln Arg Pro Phe Ile Val Gly Leu 
            180                 185                 190         


Trp Leu Lys Pro Ser Ser Gly Ser Glu Arg Ile Leu Leu Lys Ala Ala 
        195                 200                 205             


Asn Thr His Ser Ser Ser Gln Leu Cys Glu Gln Gln Ser Val His Leu 
    210                 215                 220                 


Gly Gly Val Phe Glu Leu Gln Ala Gly Ala Ser Val Phe Val Asn Val 
225                 230                 235                 240 


Thr Glu Ala Ser Gln Val Ile His Arg Val Gly Phe Ser Ser Phe Gly 
                245                 250                 255     


Leu Leu Lys Leu 
            260 


<210>  163
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  163

Met Gly Ala Leu Gly Leu Glu Gly Arg Gly Gly Arg Leu Gln Gly Arg 
1               5                   10                  15      


Gly Ser Leu Leu Leu Ala Val Ala Gly Ala Thr Ser Leu Val Thr Leu 
            20                  25                  30          


Leu Leu Ala Val Pro Ile Thr Val Leu Ala Val Leu Ala Leu Val Pro 
        35                  40                  45              


Gln Asp Gln Gly Gly Leu Val Thr Glu Thr Ala Asp Pro Gly Ala Gln 
    50                  55                  60                  


Ala Gln Gln Gly Leu Gly Phe Gln Lys Leu Pro Glu Glu Glu Pro Glu 
65                  70                  75                  80  


Thr Asp Leu Ser Pro Gly Leu Pro Ala Ala His Leu Ile Gly Ala Pro 
                85                  90                  95      


Leu Lys Gly Gln Gly Leu Gly Trp Glu Thr Thr Lys Glu Gln Ala Phe 
            100                 105                 110         


Leu Thr Ser Gly Thr Gln Phe Ser Asp Ala Glu Gly Leu Ala Leu Pro 
        115                 120                 125             


Gln Asp Gly Leu Tyr Tyr Leu Tyr Cys Leu Val Gly Tyr Arg Gly Arg 
    130                 135                 140                 


Ala Pro Pro Gly Gly Gly Asp Pro Gln Gly Arg Ser Val Thr Leu Arg 
145                 150                 155                 160 


Ser Ser Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly Thr Pro Glu 
                165                 170                 175     


Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro Val Leu Asp Pro Ala 
            180                 185                 190         


Arg Arg Gln Gly Tyr Gly Pro Leu Trp Tyr Thr Ser Val Gly Phe Gly 
        195                 200                 205             


Gly Leu Val Gln Leu Arg Arg Gly Glu Arg Val Tyr Val Asn Ile Ser 
    210                 215                 220                 


His Pro Asp Met Val Asp Phe Ala Arg Gly Lys Thr Phe Phe Gly Ala 
225                 230                 235                 240 


Val Met Val Gly 
                


<210>  164
<211>  306
<212>  PRT
<213>  Mus musculus

<400>  164

Met Gly Thr Arg Gly Leu Gln Gly Leu Gly Gly Arg Pro Gln Gly Arg 
1               5                   10                  15      


Gly Cys Leu Leu Leu Ala Val Ala Gly Ala Thr Ser Leu Val Thr Leu 
            20                  25                  30          


Leu Leu Ala Val Pro Ile Thr Val Leu Ala Val Leu Ala Leu Val Pro 
        35                  40                  45              


Gln Asp Gln Gly Arg Arg Val Glu Lys Ile Ile Gly Ser Gly Ala Gln 
    50                  55                  60                  


Ala Gln Lys Arg Leu Asp Asp Ser Lys Pro Ser Cys Ile Leu Pro Ser 
65                  70                  75                  80  


Pro Ser Ser Leu Ser Glu Thr Pro Asp Pro Arg Leu His Pro Gln Arg 
                85                  90                  95      


Ser Asn Ala Ser Arg Asn Leu Ala Ser Thr Ser Gln Gly Pro Val Ala 
            100                 105                 110         


Gln Ser Ser Arg Glu Ala Ser Ala Trp Met Thr Ile Leu Ser Pro Ala 
        115                 120                 125             


Ala Asp Ser Thr Pro Asp Pro Gly Val Gln Gln Leu Pro Lys Gly Glu 
    130                 135                 140                 


Pro Glu Thr Asp Leu Asn Pro Glu Leu Pro Ala Ala His Leu Ile Gly 
145                 150                 155                 160 


Ala Trp Met Ser Gly Gln Gly Leu Ser Trp Glu Ala Ser Gln Glu Glu 
                165                 170                 175     


Ala Phe Leu Arg Ser Gly Ala Gln Phe Ser Pro Thr His Gly Leu Ala 
            180                 185                 190         


Leu Pro Gln Asp Gly Val Tyr Tyr Leu Tyr Cys His Val Gly Tyr Arg 
        195                 200                 205             


Gly Arg Thr Pro Pro Ala Gly Arg Ser Arg Ala Arg Ser Leu Thr Leu 
    210                 215                 220                 


Arg Ser Ala Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Arg Gly Ser Pro 
225                 230                 235                 240 


Glu Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro Val Val Asp Pro 
                245                 250                 255     


Ile Gly Tyr Gly Ser Leu Trp Tyr Thr Ser Val Gly Phe Gly Gly Leu 
            260                 265                 270         


Ala Gln Leu Arg Ser Gly Glu Arg Val Tyr Val Asn Ile Ser His Pro 
        275                 280                 285             


Asp Met Val Asp Tyr Arg Arg Gly Lys Thr Phe Phe Gly Ala Val Met 
    290                 295                 300                 


Val Gly 
305     


<210>  165
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  165

Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala Leu 
1               5                   10                  15      


Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe Leu 
            20                  25                  30          


Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe Cys 
        35                  40                  45              


Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro Arg 
    50                  55                  60                  


Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser Ser 
65                  70                  75                  80  


Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro Gln 
                85                  90                  95      


Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu Leu 
            100                 105                 110         


Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser Glu 
        115                 120                 125             


Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys 
    130                 135                 140                 


Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala Val 
145                 150                 155                 160 


Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro Cys 
                165                 170                 175     


Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu Pro 
            180                 185                 190         


Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu Ser 
        195                 200                 205             


Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly Gln 
    210                 215                 220                 


Val Tyr Phe Gly Ile Ile Ala Leu 
225                 230         


<210>  166
<211>  138
<212>  PRT
<213>  Mus musculus

<400>  166

Asn His Gln Val Glu Glu Gln Leu Glu Trp Leu Ser Gln Arg Ala Asn 
1               5                   10                  15      


Ala Leu Leu Ala Asn Gly Met Asp Leu Lys Asp Asn Gln Leu Val Val 
            20                  25                  30          


Pro Ala Asp Gly Leu Tyr Leu Val Tyr Ser Gln Val Leu Phe Lys Gly 
        35                  40                  45              


Gln Gly Cys Pro Asp Tyr Val Leu Leu Thr His Thr Val Ser Arg Phe 
    50                  55                  60                  


Ala Ile Ser Tyr Gln Glu Lys Val Asn Leu Leu Ser Ala Val Lys Ser 
65                  70                  75                  80  


Pro Cys Pro Lys Asp Thr Pro Glu Gly Ala Glu Leu Lys Pro Trp Tyr 
                85                  90                  95      


Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Gln 
            100                 105                 110         


Leu Ser Ala Glu Val Asn Leu Pro Lys Tyr Leu Asp Phe Ala Glu Ser 
        115                 120                 125             


Gly Gln Val Tyr Phe Gly Val Ile Ala Leu 
    130                 135             


<210>  167
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  167

Met Thr Pro Pro Glu Arg Leu Phe Leu Pro Arg Val Cys Gly Thr Thr 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Gly Leu Leu Leu Val Leu Leu Pro Gly Ala 
            20                  25                  30          


Gln Gly Leu Pro Gly Val Gly Leu Thr Pro Ser Ala Ala Gln Thr Ala 
        35                  40                  45              


Arg Gln His Pro Lys Met His Leu Ala His Ser Thr Leu Lys Pro Ala 
    50                  55                  60                  


Ala His Leu Ile Gly Asp Pro Ser Lys Gln Asn Ser Leu Leu Trp Arg 
65                  70                  75                  80  


Ala Asn Thr Asp Arg Ala Phe Leu Gln Asp Gly Phe Ser Leu Ser Asn 
                85                  90                  95      


Asn Ser Leu Leu Val Pro Thr Ser Gly Ile Tyr Phe Val Tyr Ser Gln 
            100                 105                 110         


Val Val Phe Ser Gly Lys Ala Tyr Ser Pro Lys Ala Thr Ser Ser Pro 
        115                 120                 125             


Leu Tyr Leu Ala His Glu Val Gln Leu Phe Ser Ser Gln Tyr Pro Phe 
    130                 135                 140                 


His Val Pro Leu Leu Ser Ser Gln Lys Met Val Tyr Pro Gly Leu Gln 
145                 150                 155                 160 


Glu Pro Trp Leu His Ser Met Tyr His Gly Ala Ala Phe Gln Leu Thr 
                165                 170                 175     


Gln Gly Asp Gln Leu Ser Thr His Thr Asp Gly Ile Pro His Leu Val 
            180                 185                 190         


Leu Ser Pro Ser Thr Val Phe Phe Gly Ala Phe Ala Leu 
        195                 200                 205 


<210>  168
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  168

Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 
1               5                   10                  15      


Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 
            20                  25                  30          


Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
        35                  40                  45              


Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
    50                  55                  60                  


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
65                  70                  75                  80  


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                85                  90                  95      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            100                 105                 110         


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        115                 120                 125             


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    130                 135                 140                 


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
145                 150                 155                 160 


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                165                 170                 175     


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            180                 185                 190         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        195                 200                 205             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    210                 215                 220                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
225                 230                 235                 240 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                245                 250                 


<210>  169
<211>  309
<212>  PRT
<213>  Mus musculus

<400>  169

Met Asp Gln His Thr Leu Asp Val Glu Asp Thr Ala Asp Ala Arg His 
1               5                   10                  15      


Pro Ala Gly Thr Ser Cys Pro Ser Asp Ala Ala Leu Leu Arg Asp Thr 
            20                  25                  30          


Gly Leu Leu Ala Asp Ala Ala Leu Leu Ser Asp Thr Val Arg Pro Thr 
        35                  40                  45              


Asn Ala Ala Leu Pro Thr Asp Ala Ala Tyr Pro Ala Val Asn Val Arg 
    50                  55                  60                  


Asp Arg Glu Ala Ala Trp Pro Pro Ala Leu Asn Phe Cys Ser Arg His 
65                  70                  75                  80  


Pro Lys Leu Tyr Gly Leu Val Ala Leu Val Leu Leu Leu Leu Ile Ala 
                85                  90                  95      


Ala Cys Val Pro Ile Phe Thr Arg Thr Glu Pro Arg Pro Ala Leu Thr 
            100                 105                 110         


Ile Thr Thr Ser Pro Asn Leu Gly Thr Arg Glu Asn Asn Ala Asp Gln 
        115                 120                 125             


Val Thr Pro Val Ser His Ile Gly Cys Pro Asn Thr Thr Gln Gln Gly 
    130                 135                 140                 


Ser Pro Val Phe Ala Lys Leu Leu Ala Lys Asn Gln Ala Ser Leu Cys 
145                 150                 155                 160 


Asn Thr Thr Leu Asn Trp His Ser Gln Asp Gly Ala Gly Ser Ser Tyr 
                165                 170                 175     


Leu Ser Gln Gly Leu Arg Tyr Glu Glu Asp Lys Lys Glu Leu Val Val 
            180                 185                 190         


Asp Ser Pro Gly Leu Tyr Tyr Val Phe Leu Glu Leu Lys Leu Ser Pro 
        195                 200                 205             


Thr Phe Thr Asn Thr Gly His Lys Val Gln Gly Trp Val Ser Leu Val 
    210                 215                 220                 


Leu Gln Ala Lys Pro Gln Val Asp Asp Phe Asp Asn Leu Ala Leu Thr 
225                 230                 235                 240 


Val Glu Leu Phe Pro Cys Ser Met Glu Asn Lys Leu Val Asp Arg Ser 
                245                 250                 255     


Trp Ser Gln Leu Leu Leu Leu Lys Ala Gly His Arg Leu Ser Val Gly 
            260                 265                 270         


Leu Arg Ala Tyr Leu His Gly Ala Gln Asp Ala Tyr Arg Asp Trp Glu 
        275                 280                 285             


Leu Ser Tyr Pro Asn Thr Thr Ser Phe Gly Leu Phe Leu Val Lys Pro 
    290                 295                 300                 


Asp Asn Pro Trp Glu 
305                 


<210>  170
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  170

Ala Val Leu Thr Gln Lys Gln Lys Lys Gln His Ser Val Leu His Leu 
1               5                   10                  15      


Val Pro Ile Asn Ala Thr Ser Lys Asp Asp Ser Asp Val Thr Glu Val 
            20                  25                  30          


Met Trp Gln Pro Ala Leu Arg Arg Gly Arg Gly Leu Gln Ala Gln Gly 
        35                  40                  45              


Tyr Gly Val Arg Ile Gln Asp Ala Gly Val Tyr Leu Leu Tyr Ser Gln 
    50                  55                  60                  


Val Leu Phe Gln Asp Val Thr Phe Thr Met Gly Gln Val Val Ser Arg 
65                  70                  75                  80  


Glu Gly Gln Gly Arg Gln Glu Thr Leu Phe Arg Cys Ile Arg Ser Met 
                85                  90                  95      


Pro Ser His Pro Asp Arg Ala Tyr Asn Ser Cys Tyr Ser Ala Gly Val 
            100                 105                 110         


Phe His Leu His Gln Gly Asp Ile Leu Ser Val Ile Ile Pro Arg Ala 
        115                 120                 125             


Arg Ala Lys Leu Asn Leu Ser Pro His Gly Thr Phe Leu Gly Phe Val 
    130                 135                 140                 


Lys Leu 
145     


<210>  171
<211>  241
<212>  PRT
<213>  Mus musculus

<400>  171

Met Pro Ala Ser Ser Pro Gly His Met Gly Gly Ser Val Arg Glu Pro 
1               5                   10                  15      


Ala Leu Ser Val Ala Leu Trp Leu Ser Trp Gly Ala Val Leu Gly Ala 
            20                  25                  30          


Val Thr Cys Ala Val Ala Leu Leu Ile Gln Gln Thr Glu Leu Gln Ser 
        35                  40                  45              


Leu Arg Arg Glu Val Ser Arg Leu Gln Arg Ser Gly Gly Pro Ser Gln 
    50                  55                  60                  


Lys Gln Gly Glu Arg Pro Trp Gln Ser Leu Trp Glu Gln Ser Pro Asp 
65                  70                  75                  80  


Val Leu Glu Ala Trp Lys Asp Gly Ala Lys Ser Arg Arg Arg Arg Ala 
                85                  90                  95      


Val Leu Thr Gln Lys His Lys Lys Lys His Ser Val Leu His Leu Val 
            100                 105                 110         


Pro Val Asn Ile Thr Ser Lys Ala Asp Ser Asp Val Thr Glu Val Met 
        115                 120                 125             


Trp Gln Pro Val Leu Arg Arg Gly Arg Gly Leu Glu Ala Gln Gly Asp 
    130                 135                 140                 


Ile Val Arg Val Trp Asp Thr Gly Ile Tyr Leu Leu Tyr Ser Gln Val 
145                 150                 155                 160 


Leu Phe His Asp Val Thr Phe Thr Met Gly Gln Val Val Ser Arg Glu 
                165                 170                 175     


Gly Gln Gly Arg Arg Glu Thr Leu Phe Arg Cys Ile Arg Ser Met Pro 
            180                 185                 190         


Ser Asp Pro Asp Arg Ala Tyr Asn Ser Cys Tyr Ser Ala Gly Val Phe 
        195                 200                 205             


His Leu His Gln Gly Asp Ile Ile Thr Val Lys Ile Pro Arg Ala Asn 
    210                 215                 220                 


Ala Lys Leu Ser Leu Ser Pro His Gly Thr Phe Leu Gly Phe Val Lys 
225                 230                 235                 240 


Leu 
    


<210>  172
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  172

Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly 
1               5                   10                  15      


Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile 
            20                  25                  30          


Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu 
        35                  40                  45              


Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His 
    50                  55                  60                  


Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala 
65                  70                  75                  80  


Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu 
                85                  90                  95      


Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu 
            100                 105                 110         


Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu 
        115                 120                 125             


Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg 
    130                 135                 140                 


Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro 
145                 150                 155                 160 


Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu 
                165                 170                 175     


Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg 
            180                 185                 190         


Pro 
    


<210>  173
<211>  195
<212>  PRT
<213>  Mus musculus

<400>  173

Met Pro Glu Glu Gly Arg Pro Cys Pro Trp Val Arg Trp Ser Gly Thr 
1               5                   10                  15      


Ala Phe Gln Arg Gln Trp Pro Trp Leu Leu Leu Val Val Phe Ile Thr 
            20                  25                  30          


Val Phe Cys Cys Trp Phe His Cys Ser Gly Leu Leu Ser Lys Gln Gln 
        35                  40                  45              


Gln Arg Leu Leu Glu His Pro Glu Pro His Thr Ala Glu Leu Gln Leu 
    50                  55                  60                  


Asn Leu Thr Val Pro Arg Lys Asp Pro Thr Leu Arg Trp Gly Ala Gly 
65                  70                  75                  80  


Pro Ala Leu Gly Arg Ser Phe Thr His Gly Pro Glu Leu Glu Glu Gly 
                85                  90                  95      


His Leu Arg Ile His Gln Asp Gly Leu Tyr Arg Leu His Ile Gln Val 
            100                 105                 110         


Thr Leu Ala Asn Cys Ser Ser Pro Gly Ser Thr Leu Gln His Arg Ala 
        115                 120                 125             


Thr Leu Ala Val Gly Ile Cys Ser Pro Ala Ala His Gly Ile Ser Leu 
    130                 135                 140                 


Leu Arg Gly Arg Phe Gly Gln Asp Cys Thr Val Ala Leu Gln Arg Leu 
145                 150                 155                 160 


Thr Tyr Leu Val His Gly Asp Val Leu Cys Thr Asn Leu Thr Leu Pro 
                165                 170                 175     


Leu Leu Pro Ser Arg Asn Ala Asp Glu Thr Phe Phe Gly Val Gln Trp 
            180                 185                 190         


Ile Cys Pro 
        195 


<210>  174
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  174

Met Asp Pro Gly Leu Gln Gln Ala Leu Asn Gly Met Ala Pro Pro Gly 
1               5                   10                  15      


Asp Thr Ala Met His Val Pro Ala Gly Ser Val Ala Ser His Leu Gly 
            20                  25                  30          


Thr Thr Ser Arg Ser Tyr Phe Tyr Leu Thr Thr Ala Thr Leu Ala Leu 
        35                  40                  45              


Cys Leu Val Phe Thr Val Ala Thr Ile Met Val Leu Val Val Gln Arg 
    50                  55                  60                  


Thr Asp Ser Ile Pro Asn Ser Pro Asp Asn Val Pro Leu Lys Gly Gly 
65                  70                  75                  80  


Asn Cys Ser Glu Asp Leu Leu Cys Ile Leu Lys Arg Ala Pro Phe Lys 
                85                  90                  95      


Lys Ser Trp Ala Tyr Leu Gln Val Ala Lys His Leu Asn Lys Thr Lys 
            100                 105                 110         


Leu Ser Trp Asn Lys Asp Gly Ile Leu His Gly Val Arg Tyr Gln Asp 
        115                 120                 125             


Gly Asn Leu Val Ile Gln Phe Pro Gly Leu Tyr Phe Ile Ile Cys Gln 
    130                 135                 140                 


Leu Gln Phe Leu Val Gln Cys Pro Asn Asn Ser Val Asp Leu Lys Leu 
145                 150                 155                 160 


Glu Leu Leu Ile Asn Lys His Ile Lys Lys Gln Ala Leu Val Thr Val 
                165                 170                 175     


Cys Glu Ser Gly Met Gln Thr Lys His Val Tyr Gln Asn Leu Ser Gln 
            180                 185                 190         


Phe Leu Leu Asp Tyr Leu Gln Val Asn Thr Thr Ile Ser Val Asn Val 
        195                 200                 205             


Asp Thr Phe Gln Tyr Ile Asp Thr Ser Thr Phe Pro Leu Glu Asn Val 
    210                 215                 220                 


Leu Ser Ile Phe Leu Tyr Ser Asn Ser Asp 
225                 230                 


<210>  175
<211>  239
<212>  PRT
<213>  Mus musculus

<400>  175

Met Glu Pro Gly Leu Gln Gln Ala Gly Ser Cys Gly Ala Pro Ser Pro 
1               5                   10                  15      


Asp Pro Ala Met Gln Val Gln Pro Gly Ser Val Ala Ser Pro Trp Arg 
            20                  25                  30          


Ser Thr Arg Pro Trp Arg Ser Thr Ser Arg Ser Tyr Phe Tyr Leu Ser 
        35                  40                  45              


Thr Thr Ala Leu Val Cys Leu Val Val Ala Val Ala Ile Ile Leu Val 
    50                  55                  60                  


Leu Val Val Gln Lys Lys Asp Ser Thr Pro Asn Thr Thr Glu Lys Ala 
65                  70                  75                  80  


Pro Leu Lys Gly Gly Asn Cys Ser Glu Asp Leu Phe Cys Thr Leu Lys 
                85                  90                  95      


Ser Thr Pro Ser Lys Lys Ser Trp Ala Tyr Leu Gln Val Ser Lys His 
            100                 105                 110         


Leu Asn Asn Thr Lys Leu Ser Trp Asn Glu Asp Gly Thr Ile His Gly 
        115                 120                 125             


Leu Ile Tyr Gln Asp Gly Asn Leu Ile Val Gln Phe Pro Gly Leu Tyr 
    130                 135                 140                 


Phe Ile Val Cys Gln Leu Gln Phe Leu Val Gln Cys Ser Asn His Ser 
145                 150                 155                 160 


Val Asp Leu Thr Leu Gln Leu Leu Ile Asn Ser Lys Ile Lys Lys Gln 
                165                 170                 175     


Thr Leu Val Thr Val Cys Glu Ser Gly Val Gln Ser Lys Asn Ile Tyr 
            180                 185                 190         


Gln Asn Leu Ser Gln Phe Leu Leu His Tyr Leu Gln Val Asn Ser Thr 
        195                 200                 205             


Ile Ser Val Arg Val Asp Asn Phe Gln Tyr Val Asp Thr Asn Thr Phe 
    210                 215                 220                 


Pro Leu Asp Asn Val Leu Ser Val Phe Leu Tyr Ser Ser Ser Asp 
225                 230                 235                 


<210>  176
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  176

Met Gln Gln Pro Phe Asn Tyr Pro Tyr Pro Gln Ile Tyr Trp Val Asp 
1               5                   10                  15      


Ser Ser Ala Ser Ser Pro Trp Ala Pro Pro Gly Thr Val Leu Pro Cys 
            20                  25                  30          


Pro Thr Ser Val Pro Arg Arg Pro Gly Gln Arg Arg Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro 
    50                  55                  60                  


Pro Leu Pro Leu Pro Pro Leu Lys Lys Arg Gly Asn His Ser Thr Gly 
65                  70                  75                  80  


Leu Cys Leu Leu Val Met Phe Phe Met Val Leu Val Ala Leu Val Gly 
                85                  90                  95      


Leu Gly Leu Gly Met Phe Gln Leu Phe His Leu Gln Lys Glu Leu Ala 
            100                 105                 110         


Glu Leu Arg Glu Ser Thr Ser Gln Met His Thr Ala Ser Ser Leu Glu 
        115                 120                 125             


Lys Gln Ile Gly His Pro Ser Pro Pro Pro Glu Lys Lys Glu Leu Arg 
    130                 135                 140                 


Lys Val Ala His Leu Thr Gly Lys Ser Asn Ser Arg Ser Met Pro Leu 
145                 150                 155                 160 


Glu Trp Glu Asp Thr Tyr Gly Ile Val Leu Leu Ser Gly Val Lys Tyr 
                165                 170                 175     


Lys Lys Gly Gly Leu Val Ile Asn Glu Thr Gly Leu Tyr Phe Val Tyr 
            180                 185                 190         


Ser Lys Val Tyr Phe Arg Gly Gln Ser Cys Asn Asn Leu Pro Leu Ser 
        195                 200                 205             


His Lys Val Tyr Met Arg Asn Ser Lys Tyr Pro Gln Asp Leu Val Met 
    210                 215                 220                 


Met Glu Gly Lys Met Met Ser Tyr Cys Thr Thr Gly Gln Met Trp Ala 
225                 230                 235                 240 


Arg Ser Ser Tyr Leu Gly Ala Val Phe Asn Leu Thr Ser Ala Asp His 
                245                 250                 255     


Leu Tyr Val Asn Val Ser Glu Leu Ser Leu Val Asn Phe Glu Glu Ser 
            260                 265                 270         


Gln Thr Phe Phe Gly Leu Tyr Lys Leu 
        275                 280     


<210>  177
<211>  279
<212>  PRT
<213>  Mus musculus

<400>  177

Met Gln Gln Pro Met Asn Tyr Pro Cys Pro Gln Ile Phe Trp Val Asp 
1               5                   10                  15      


Ser Ser Ala Thr Ser Ser Trp Ala Pro Pro Gly Ser Val Phe Pro Cys 
            20                  25                  30          


Pro Ser Cys Gly Pro Arg Gly Pro Asp Gln Arg Arg Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Pro Val Ser Pro Leu Pro Pro Pro Ser Gln Pro Leu Pro Leu 
    50                  55                  60                  


Pro Pro Leu Thr Pro Leu Lys Lys Lys Asp His Asn Thr Asn Leu Trp 
65                  70                  75                  80  


Leu Pro Val Val Phe Phe Met Val Leu Val Ala Leu Val Gly Met Gly 
                85                  90                  95      


Leu Gly Met Tyr Gln Leu Phe His Leu Gln Lys Glu Leu Ala Glu Leu 
            100                 105                 110         


Arg Glu Phe Thr Asn Gln Ser Leu Lys Val Ser Ser Phe Glu Lys Gln 
        115                 120                 125             


Ile Ala Asn Pro Ser Thr Pro Ser Glu Lys Lys Glu Pro Arg Ser Val 
    130                 135                 140                 


Ala His Leu Thr Gly Asn Pro His Ser Arg Ser Ile Pro Leu Glu Trp 
145                 150                 155                 160 


Glu Asp Thr Tyr Gly Thr Ala Leu Ile Ser Gly Val Lys Tyr Lys Lys 
                165                 170                 175     


Gly Gly Leu Val Ile Asn Glu Thr Gly Leu Tyr Phe Val Tyr Ser Lys 
            180                 185                 190         


Val Tyr Phe Arg Gly Gln Ser Cys Asn Asn Gln Pro Leu Asn His Lys 
        195                 200                 205             


Val Tyr Met Arg Asn Ser Lys Tyr Pro Glu Asp Leu Val Leu Met Glu 
    210                 215                 220                 


Glu Lys Arg Leu Asn Tyr Cys Thr Thr Gly Gln Ile Trp Ala His Ser 
225                 230                 235                 240 


Ser Tyr Leu Gly Ala Val Phe Asn Leu Thr Ser Ala Asp His Leu Tyr 
                245                 250                 255     


Val Asn Ile Ser Gln Leu Ser Leu Ile Asn Phe Glu Glu Ser Lys Thr 
            260                 265                 270         


Phe Phe Gly Leu Tyr Lys Leu 
        275                 


<210>  178
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  178

Met Thr Leu His Pro Ser Pro Ile Thr Cys Glu Phe Leu Phe Ser Thr 
1               5                   10                  15      


Ala Leu Ile Ser Pro Lys Met Cys Leu Ser His Leu Glu Asn Met Pro 
            20                  25                  30          


Leu Ser His Ser Arg Thr Gln Gly Ala Gln Arg Ser Ser Trp Lys Leu 
        35                  40                  45              


Trp Leu Phe Cys Ser Ile Val Met Leu Leu Phe Leu Cys Ser Phe Ser 
    50                  55                  60                  


Trp Leu Ile Phe Ile Phe Leu Gln Leu Glu Thr Ala Lys Glu Pro Cys 
65                  70                  75                  80  


Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser Ser 
                85                  90                  95      


Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile Leu 
            100                 105                 110         


Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn 
        115                 120                 125             


Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp 
    130                 135                 140                 


Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly Gly 
145                 150                 155                 160 


Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser 
                165                 170                 175     


Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu 
            180                 185                 190         


Ala Asn Pro Gln Phe Ile Ser 
        195                 


<210>  179
<211>  173
<212>  PRT
<213>  Mus musculus

<400>  179

Met Glu Glu Met Pro Leu Arg Glu Ser Ser Pro Gln Arg Ala Glu Arg 
1               5                   10                  15      


Cys Lys Lys Ser Trp Leu Leu Cys Ile Val Ala Leu Leu Leu Met Leu 
            20                  25                  30          


Leu Cys Ser Leu Gly Thr Leu Ile Tyr Thr Ser Leu Lys Pro Thr Ala 
        35                  40                  45              


Ile Glu Ser Cys Met Val Lys Phe Glu Leu Ser Ser Ser Lys Trp His 
    50                  55                  60                  


Met Thr Ser Pro Lys Pro His Cys Val Asn Thr Thr Ser Asp Gly Lys 
65                  70                  75                  80  


Leu Lys Ile Leu Gln Ser Gly Thr Tyr Leu Ile Tyr Gly Gln Val Ile 
                85                  90                  95      


Pro Val Asp Lys Lys Tyr Ile Lys Asp Asn Ala Pro Phe Val Val Gln 
            100                 105                 110         


Ile Tyr Lys Lys Asn Asp Val Leu Gln Thr Leu Met Asn Asp Phe Gln 
        115                 120                 125             


Ile Leu Pro Ile Gly Gly Val Tyr Glu Leu His Ala Gly Asp Asn Ile 
    130                 135                 140                 


Tyr Leu Lys Phe Asn Ser Lys Asp His Ile Gln Lys Thr Asn Thr Tyr 
145                 150                 155                 160 


Trp Gly Ile Ile Leu Met Pro Asp Leu Pro Phe Ile Ser 
                165                 170             


<210>  180
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  180

Met Glu Glu Ser Val Val Arg Pro Ser Val Phe Val Val Asp Gly Gln 
1               5                   10                  15      


Thr Asp Ile Pro Phe Thr Arg Leu Gly Arg Ser His Arg Arg Gln Ser 
            20                  25                  30          


Cys Ser Val Ala Arg Val Gly Leu Gly Leu Leu Leu Leu Leu Met Gly 
        35                  40                  45              


Ala Gly Leu Ala Val Gln Gly Trp Phe Leu Leu Gln Leu His Trp Arg 
    50                  55                  60                  


Leu Gly Glu Met Val Thr Arg Leu Pro Asp Gly Pro Ala Gly Ser Trp 
65                  70                  75                  80  


Glu Gln Leu Ile Gln Glu Arg Arg Ser His Glu Val Asn Pro Ala Ala 
                85                  90                  95      


His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu 
            100                 105                 110         


Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr 
        115                 120                 125             


His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr 
    130                 135                 140                 


Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser 
145                 150                 155                 160 


Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu 
                165                 170                 175     


Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser 
            180                 185                 190         


Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His 
        195                 200                 205             


Leu Glu Ala Gly Glu Lys Val Val Val Arg Val Leu Asp Glu Arg Leu 
    210                 215                 220                 


Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
225                 230                 235                 240 


<210>  181
<211>  239
<212>  PRT
<213>  Mus musculus

<400>  181

Met Glu Ser Val Val Gln Pro Ser Val Phe Val Val Asp Gly Gln Thr 
1               5                   10                  15      


Asp Ile Pro Phe Arg Arg Leu Glu Gln Asn His Arg Arg Arg Arg Cys 
            20                  25                  30          


Gly Thr Val Gln Val Ser Leu Ala Leu Val Leu Leu Leu Gly Ala Gly 
        35                  40                  45              


Leu Ala Thr Gln Gly Trp Phe Leu Leu Arg Leu His Gln Arg Leu Gly 
    50                  55                  60                  


Asp Ile Val Ala His Leu Pro Asp Gly Gly Lys Gly Ser Trp Glu Lys 
65                  70                  75                  80  


Leu Ile Gln Asp Gln Arg Ser His Gln Ala Asn Pro Ala Ala His Leu 
                85                  90                  95      


Thr Gly Ala Asn Ala Ser Leu Ile Gly Ile Gly Gly Pro Leu Leu Trp 
            100                 105                 110         


Glu Thr Arg Leu Gly Leu Ala Phe Leu Arg Gly Leu Thr Tyr His Asp 
        115                 120                 125             


Gly Ala Leu Val Thr Met Glu Pro Gly Tyr Tyr Tyr Val Tyr Ser Lys 
    130                 135                 140                 


Val Gln Leu Ser Gly Val Gly Cys Pro Gln Gly Leu Ala Asn Gly Leu 
145                 150                 155                 160 


Pro Ile Thr His Gly Leu Tyr Lys Arg Thr Ser Arg Tyr Pro Lys Glu 
                165                 170                 175     


Leu Glu Leu Leu Val Ser Arg Arg Ser Pro Cys Gly Arg Ala Asn Ser 
            180                 185                 190         


Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His Leu 
        195                 200                 205             


Glu Ala Gly Glu Glu Val Val Val Arg Val Pro Gly Asn Arg Leu Val 
    210                 215                 220                 


Arg Pro Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
225                 230                 235                 


<210>  182
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  182

Met Glu Arg Val Gln Pro Leu Glu Glu Asn Val Gly Asn Ala Ala Arg 
1               5                   10                  15      


Pro Arg Phe Glu Arg Asn Lys Leu Leu Leu Val Ala Ser Val Ile Gln 
            20                  25                  30          


Gly Leu Gly Leu Leu Leu Cys Phe Thr Tyr Ile Cys Leu His Phe Ser 
        35                  40                  45              


Ala Leu Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val 
    50                  55                  60                  


Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln 
65                  70                  75                  80  


Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn 
                85                  90                  95      


Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu 
            100                 105                 110         


Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln 
        115                 120                 125             


Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr 
    130                 135                 140                 


Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu 
145                 150                 155                 160 


Asp Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn 
                165                 170                 175     


Pro Gly Glu Phe Cys Val Leu 
            180             


<210>  183
<211>  197
<212>  PRT
<213>  Mus musculus

<400>  183

Met Glu Gly Glu Gly Val Gln Pro Leu Asp Glu Asn Leu Glu Asn Gly 
1               5                   10                  15      


Ser Arg Pro Arg Phe Lys Trp Lys Lys Thr Leu Arg Leu Val Val Ser 
            20                  25                  30          


Gly Ile Lys Gly Ala Gly Met Leu Leu Cys Phe Ile Tyr Val Cys Leu 
        35                  40                  45              


Gln Leu Ser Ser Ser Pro Ala Lys Asp Pro Pro Ile Gln Arg Leu Arg 
    50                  55                  60                  


Gly Ala Val Thr Arg Cys Glu Asp Gly Gln Leu Phe Ile Ser Ser Tyr 
65                  70                  75                  80  


Lys Asn Glu Tyr Gln Thr Met Glu Val Gln Asn Asn Ser Val Val Ile 
                85                  90                  95      


Lys Cys Asp Gly Leu Tyr Ile Ile Tyr Leu Lys Gly Ser Phe Phe Gln 
            100                 105                 110         


Glu Val Lys Ile Asp Leu His Phe Arg Glu Asp His Asn Pro Ile Ser 
        115                 120                 125             


Ile Pro Met Leu Asn Asp Gly Arg Arg Ile Val Phe Thr Val Val Ala 
    130                 135                 140                 


Ser Leu Ala Phe Lys Asp Lys Val Tyr Leu Thr Val Asn Ala Pro Asp 
145                 150                 155                 160 


Thr Leu Cys Glu His Leu Gln Ile Asn Asp Gly Glu Leu Ile Val Val 
                165                 170                 175     


Gln Leu Thr Pro Gly Tyr Cys Ala Pro Glu Gly Ser Tyr His Ser Thr 
            180                 185                 190         


Val Asn Gln Val Pro 
        195         


<210>  184
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  184

Met Asp Asp Ser Thr Glu Arg Glu Gln Ser Arg Leu Thr Ser Cys Leu 
1               5                   10                  15      


Lys Lys Arg Glu Glu Met Lys Leu Lys Glu Cys Val Ser Ile Leu Pro 
            20                  25                  30          


Arg Lys Glu Ser Pro Ser Val Arg Ser Ser Lys Asp Gly Lys Leu Leu 
        35                  40                  45              


Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Cys Cys Leu Thr Val Val 
    50                  55                  60                  


Ser Phe Tyr Gln Val Ala Ala Leu Gln Gly Asp Leu Ala Ser Leu Arg 
65                  70                  75                  80  


Ala Glu Leu Gln Gly His His Ala Glu Lys Leu Pro Ala Gly Ala Gly 
                85                  90                  95      


Ala Pro Lys Ala Gly Leu Glu Glu Ala Pro Ala Val Thr Ala Gly Leu 
            100                 105                 110         


Lys Ile Phe Glu Pro Pro Ala Pro Gly Glu Gly Asn Ser Ser Gln Asn 
        115                 120                 125             


Ser Arg Asn Lys Arg Ala Val Gln Gly Pro Glu Glu Thr Val Thr Gln 
    130                 135                 140                 


Asp Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys 
145                 150                 155                 160 


Gly Ser Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser 
                165                 170                 175     


Ala Leu Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr 
            180                 185                 190         


Phe Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met 
        195                 200                 205             


Gly His Leu Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu 
    210                 215                 220                 


Ser Leu Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu 
225                 230                 235                 240 


Pro Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly 
                245                 250                 255     


Asp Glu Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu 
            260                 265                 270         


Asp Gly Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu 
        275                 280                 285 


<210>  185
<211>  249
<212>  PRT
<213>  Mus musculus

<400>  185

Met Ala Met Ala Phe Cys Pro Lys Asp Gln Tyr Trp Asp Ser Ser Arg 
1               5                   10                  15      


Lys Ser Cys Val Ser Cys Ala Leu Thr Cys Ser Gln Arg Ser Gln Arg 
            20                  25                  30          


Thr Cys Thr Asp Phe Cys Lys Phe Ile Asn Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Arg Tyr Tyr Asp His Leu Leu Gly Ala Cys Val Ser Cys Asp Ser Thr 
    50                  55                  60                  


Cys Thr Gln His Pro Gln Gln Cys Ala His Phe Cys Glu Lys Arg Pro 
65                  70                  75                  80  


Arg Ser Gln Ala Asn Leu Gln Pro Glu Leu Gly Arg Pro Gln Ala Gly 
                85                  90                  95      


Glu Val Glu Val Arg Ser Asp Asn Ser Gly Arg His Gln Gly Ser Glu 
            100                 105                 110         


His Gly Pro Gly Leu Arg Leu Ser Ser Asp Gln Leu Thr Leu Tyr Cys 
        115                 120                 125             


Thr Leu Gly Val Cys Leu Cys Ala Ile Phe Cys Cys Phe Leu Val Ala 
    130                 135                 140                 


Leu Ala Ser Phe Leu Arg Arg Arg Gly Glu Pro Leu Pro Ser Gln Pro 
145                 150                 155                 160 


Ala Gly Pro Arg Gly Ser Gln Ala Asn Ser Pro His Ala His Arg Pro 
                165                 170                 175     


Val Thr Glu Ala Cys Asp Glu Val Thr Ala Ser Pro Gln Pro Val Glu 
            180                 185                 190         


Thr Cys Ser Phe Cys Phe Pro Glu Arg Ser Ser Pro Thr Gln Glu Ser 
        195                 200                 205             


Ala Pro Arg Ser Leu Gly Ile His Gly Phe Ala Gly Thr Ala Ala Pro 
    210                 215                 220                 


Gln Pro Cys Met Arg Ala Thr Val Gly Gly Leu Gly Val Leu Arg Ala 
225                 230                 235                 240 


Ser Thr Gly Asp Ala Arg Pro Ala Thr 
                245                 


<210>  186
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  186

Met Ala Met Met Glu Val Gln Gly Gly Pro Ser Leu Gly Gln Thr Cys 
1               5                   10                  15      


Val Leu Ile Val Ile Phe Thr Val Leu Leu Gln Ser Leu Cys Val Ala 
            20                  25                  30          


Val Thr Tyr Val Tyr Phe Thr Asn Glu Leu Lys Gln Met Gln Asp Lys 
        35                  40                  45              


Tyr Ser Lys Ser Gly Ile Ala Cys Phe Leu Lys Glu Asp Asp Ser Tyr 
    50                  55                  60                  


Trp Asp Pro Asn Asp Glu Glu Ser Met Asn Ser Pro Cys Trp Gln Val 
65                  70                  75                  80  


Lys Trp Gln Leu Arg Gln Leu Val Arg Lys Met Ile Leu Arg Thr Ser 
                85                  90                  95      


Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro 
            100                 105                 110         


Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly 
        115                 120                 125             


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
    130                 135                 140                 


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
145                 150                 155                 160 


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
                165                 170                 175     


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
            180                 185                 190         


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
        195                 200                 205             


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
    210                 215                 220                 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
225                 230                 235                 240 


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
                245                 250                 255     


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
            260                 265                 270         


Ser Phe Phe Gly Ala Phe Leu Val Gly 
        275                 280     


<210>  187
<211>  291
<212>  PRT
<213>  Mus musculus

<400>  187

Met Pro Ser Ser Gly Ala Leu Lys Asp Leu Ser Phe Ser Gln His Phe 
1               5                   10                  15      


Arg Met Met Val Ile Cys Ile Val Leu Leu Gln Val Leu Leu Gln Ala 
            20                  25                  30          


Val Ser Val Ala Val Thr Tyr Met Tyr Phe Thr Asn Glu Met Lys Gln 
        35                  40                  45              


Leu Gln Asp Asn Tyr Ser Lys Ile Gly Leu Ala Cys Phe Ser Lys Thr 
    50                  55                  60                  


Asp Glu Asp Phe Trp Asp Ser Thr Asp Gly Glu Ile Leu Asn Arg Pro 
65                  70                  75                  80  


Cys Leu Gln Val Lys Arg Gln Leu Tyr Gln Leu Ile Glu Glu Val Thr 
                85                  90                  95      


Leu Arg Thr Phe Gln Asp Thr Ile Ser Thr Val Pro Glu Lys Gln Leu 
            100                 105                 110         


Ser Thr Pro Pro Leu Pro Arg Gly Gly Arg Pro Gln Lys Val Ala Ala 
        115                 120                 125             


His Ile Thr Gly Ile Thr Arg Arg Ser Asn Ser Ala Leu Ile Pro Ile 
    130                 135                 140                 


Ser Lys Asp Gly Lys Thr Leu Gly Gln Lys Ile Glu Ser Trp Glu Ser 
145                 150                 155                 160 


Ser Arg Lys Gly His Ser Phe Leu Asn His Val Leu Phe Arg Asn Gly 
                165                 170                 175     


Glu Leu Val Ile Glu Gln Glu Gly Leu Tyr Tyr Ile Tyr Ser Gln Thr 
            180                 185                 190         


Tyr Phe Arg Phe Gln Glu Ala Glu Asp Ala Ser Lys Met Val Ser Lys 
        195                 200                 205             


Asp Lys Val Arg Thr Lys Gln Leu Val Gln Tyr Ile Tyr Lys Tyr Thr 
    210                 215                 220                 


Ser Tyr Pro Asp Pro Ile Val Leu Met Lys Ser Ala Arg Asn Ser Cys 
225                 230                 235                 240 


Trp Ser Arg Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly 
                245                 250                 255     


Leu Phe Glu Leu Lys Lys Asn Asp Arg Ile Phe Val Ser Val Thr Asn 
            260                 265                 270         


Glu His Leu Met Asp Leu Asp Gln Glu Ala Ser Phe Phe Gly Ala Phe 
        275                 280                 285             


Leu Ile Asn 
    290     


<210>  188
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  188

Met Ala Ala Arg Arg Ser Gln Arg Arg Arg Gly Arg Arg Gly Glu Pro 
1               5                   10                  15      


Gly Thr Ala Leu Leu Val Pro Leu Ala Leu Gly Leu Gly Leu Ala Leu 
            20                  25                  30          


Ala Cys Leu Gly Leu Leu Leu Ala Val Val Ser Leu Gly Ser Arg Ala 
        35                  40                  45              


Ser Leu Ser Ala Gln Glu Pro Ala Gln Glu Glu Leu Val Ala Glu Glu 
    50                  55                  60                  


Asp Gln Asp Pro Ser Glu Leu Asn Pro Gln Thr Glu Glu Ser Gln Asp 
65                  70                  75                  80  


Pro Ala Pro Phe Leu Asn Arg Leu Val Arg Pro Arg Arg Ser Ala Pro 
                85                  90                  95      


Lys Gly Arg Lys Thr Arg Ala Arg Arg Ala Ile Ala Ala His Tyr Glu 
            100                 105                 110         


Val His Pro Arg Pro Gly Gln Asp Gly Ala Gln Ala Gly Val Asp Gly 
        115                 120                 125             


Thr Val Ser Gly Trp Glu Glu Ala Arg Ile Asn Ser Ser Ser Pro Leu 
    130                 135                 140                 


Arg Tyr Asn Arg Gln Ile Gly Glu Phe Ile Val Thr Arg Ala Gly Leu 
145                 150                 155                 160 


Tyr Tyr Leu Tyr Cys Gln Val His Phe Asp Glu Gly Lys Ala Val Tyr 
                165                 170                 175     


Leu Lys Leu Asp Leu Leu Val Asp Gly Val Leu Ala Leu Arg Cys Leu 
            180                 185                 190         


Glu Glu Phe Ser Ala Thr Ala Ala Ser Ser Leu Gly Pro Gln Leu Arg 
        195                 200                 205             


Leu Cys Gln Val Ser Gly Leu Leu Ala Leu Arg Pro Gly Ser Ser Leu 
    210                 215                 220                 


Arg Ile Arg Thr Leu Pro Trp Ala His Leu Lys Ala Ala Pro Phe Leu 
225                 230                 235                 240 


Thr Tyr Phe Gly Leu Phe Gln Val His 
                245                 


<210>  189
<211>  129
<212>  PRT
<213>  Mus musculus

<400>  189

Met Ala Ser Ala Trp Pro Arg Ser Leu Pro Gln Ile Leu Val Leu Gly 
1               5                   10                  15      


Phe Gly Leu Val Leu Met Arg Ala Ala Ala Gly Glu Gln Ala Pro Gly 
            20                  25                  30          


Thr Ser Pro Cys Ser Ser Gly Ser Ser Trp Ser Ala Asp Leu Asp Lys 
        35                  40                  45              


Cys Met Asp Cys Ala Ser Cys Pro Ala Arg Pro His Ser Asp Phe Cys 
    50                  55                  60                  


Leu Gly Cys Ala Ala Ala Pro Pro Ala His Phe Arg Leu Leu Trp Pro 
65                  70                  75                  80  


Ile Leu Gly Gly Ala Leu Ser Leu Val Leu Val Leu Ala Leu Val Ser 
                85                  90                  95      


Ser Phe Leu Val Trp Arg Arg Cys Arg Arg Arg Glu Lys Phe Thr Thr 
            100                 105                 110         


Pro Ile Glu Glu Thr Gly Gly Glu Gly Cys Pro Gly Val Ala Leu Ile 
        115                 120                 125             


Gln 
    


<210>  190
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  190

Met Arg Arg Ala Ser Arg Asp Tyr Thr Lys Tyr Leu Arg Gly Ser Glu 
1               5                   10                  15      


Glu Met Gly Gly Gly Pro Gly Ala Pro His Glu Gly Pro Leu His Ala 
            20                  25                  30          


Pro Pro Pro Pro Ala Pro His Gln Pro Pro Ala Ala Ser Arg Ser Met 
        35                  40                  45              


Phe Val Ala Leu Leu Gly Leu Gly Leu Gly Gln Val Val Cys Ser Val 
    50                  55                  60                  


Ala Leu Phe Phe Tyr Phe Arg Ala Gln Met Asp Pro Asn Arg Ile Ser 
65                  70                  75                  80  


Glu Asp Gly Thr His Cys Ile Tyr Arg Ile Leu Arg Leu His Glu Asn 
                85                  90                  95      


Ala Asp Phe Gln Asp Thr Thr Leu Glu Ser Gln Asp Thr Lys Leu Ile 
            100                 105                 110         


Pro Asp Ser Cys Arg Arg Ile Lys Gln Ala Phe Gln Gly Ala Val Gln 
        115                 120                 125             


Lys Glu Leu Gln His Ile Val Gly Ser Gln His Ile Arg Ala Glu Lys 
    130                 135                 140                 


Ala Met Val Asp Gly Ser Trp Leu Asp Leu Ala Lys Arg Ser Lys Leu 
145                 150                 155                 160 


Glu Ala Gln Pro Phe Ala His Leu Thr Ile Asn Ala Thr Asp Ile Pro 
                165                 170                 175     


Ser Gly Ser His Lys Val Ser Leu Ser Ser Trp Tyr His Asp Arg Gly 
            180                 185                 190         


Trp Ala Lys Ile Ser Asn Met Thr Phe Ser Asn Gly Lys Leu Ile Val 
        195                 200                 205             


Asn Gln Asp Gly Phe Tyr Tyr Leu Tyr Ala Asn Ile Cys Phe Arg His 
    210                 215                 220                 


His Glu Thr Ser Gly Asp Leu Ala Thr Glu Tyr Leu Gln Leu Met Val 
225                 230                 235                 240 


Tyr Val Thr Lys Thr Ser Ile Lys Ile Pro Ser Ser His Thr Leu Met 
                245                 250                 255     


Lys Gly Gly Ser Thr Lys Tyr Trp Ser Gly Asn Ser Glu Phe His Phe 
            260                 265                 270         


Tyr Ser Ile Asn Val Gly Gly Phe Phe Lys Leu Arg Ser Gly Glu Glu 
        275                 280                 285             


Ile Ser Ile Glu Val Ser Asn Pro Ser Leu Leu Asp Pro Asp Gln Asp 
    290                 295                 300                 


Ala Thr Tyr Phe Gly Ala Phe Lys Val Arg Asp Ile Asp 
305                 310                 315         


<210>  191
<211>  316
<212>  PRT
<213>  Mus musculus

<400>  191

Met Arg Arg Ala Ser Arg Asp Tyr Gly Lys Tyr Leu Arg Ser Ser Glu 
1               5                   10                  15      


Glu Met Gly Ser Gly Pro Gly Val Pro His Glu Gly Pro Leu His Pro 
            20                  25                  30          


Ala Pro Ser Ala Pro Ala Pro Ala Pro Pro Pro Ala Ala Ser Arg Ser 
        35                  40                  45              


Met Phe Leu Ala Leu Leu Gly Leu Gly Leu Gly Gln Val Val Cys Ser 
    50                  55                  60                  


Ile Ala Leu Phe Leu Tyr Phe Arg Ala Gln Met Asp Pro Asn Arg Ile 
65                  70                  75                  80  


Ser Glu Asp Ser Thr His Cys Phe Tyr Arg Ile Leu Arg Leu His Glu 
                85                  90                  95      


Asn Ala Asp Leu Gln Asp Ser Thr Leu Glu Ser Glu Asp Thr Leu Pro 
            100                 105                 110         


Asp Ser Cys Arg Arg Met Lys Gln Ala Phe Gln Gly Ala Val Gln Lys 
        115                 120                 125             


Glu Leu Gln His Ile Val Gly Pro Gln Arg Phe Ser Gly Ala Pro Ala 
    130                 135                 140                 


Met Met Glu Gly Ser Trp Leu Asp Val Ala Gln Arg Gly Lys Pro Glu 
145                 150                 155                 160 


Ala Gln Pro Phe Ala His Leu Thr Ile Asn Ala Ala Ser Ile Pro Ser 
                165                 170                 175     


Gly Ser His Lys Val Thr Leu Ser Ser Trp Tyr His Asp Arg Gly Trp 
            180                 185                 190         


Ala Lys Ile Ser Asn Met Thr Leu Ser Asn Gly Lys Leu Arg Val Asn 
        195                 200                 205             


Gln Asp Gly Phe Tyr Tyr Leu Tyr Ala Asn Ile Cys Phe Arg His His 
    210                 215                 220                 


Glu Thr Ser Gly Ser Val Pro Thr Asp Tyr Leu Gln Leu Met Val Tyr 
225                 230                 235                 240 


Val Val Lys Thr Ser Ile Lys Ile Pro Ser Ser His Asn Leu Met Lys 
                245                 250                 255     


Gly Gly Ser Thr Lys Asn Trp Ser Gly Asn Ser Glu Phe His Phe Tyr 
            260                 265                 270         


Ser Ile Asn Val Gly Gly Phe Phe Lys Leu Arg Ala Gly Glu Glu Ile 
        275                 280                 285             


Ser Ile Gln Val Ser Asn Pro Ser Leu Leu Asp Pro Asp Gln Asp Ala 
    290                 295                 300                 


Thr Tyr Phe Gly Ala Phe Lys Val Gln Asp Ile Asp 
305                 310                 315     


<210>  192
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  192

Met Pro Pro Ser Gly Leu Arg Leu Leu Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 
            20                  25                  30          


Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 
        35                  40                  45              


Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 
    50                  55                  60                  


Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 
65                  70                  75                  80  


Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu 
                85                  90                  95      


Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 
            100                 105                 110         


Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys Gln Ser Thr 
        115                 120                 125             


His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 
    130                 135                 140                 


Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu 
145                 150                 155                 160 


Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 
                165                 170                 175     


Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser 
            180                 185                 190         


Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 
        195                 200                 205             


Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala His Cys Ser 
    210                 215                 220                 


Cys Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Thr 
225                 230                 235                 240 


Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro 
                245                 250                 255     


Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu Gln 
            260                 265                 270         


Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 
        275                 280                 285             


Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 
    290                 295                 300                 


Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 
305                 310                 315                 320 


Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 
                325                 330                 335     


Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 
            340                 345                 350         


Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 
        355                 360                 365             


Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 
    370                 375                 380                 


Arg Ser Cys Lys Cys Ser 
385                 390 


<210>  193
<211>  390
<212>  PRT
<213>  Mus musculus

<400>  193

Met Pro Pro Ser Gly Leu Arg Leu Leu Pro Leu Leu Leu Pro Leu Pro 
1               5                   10                  15      


Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 
            20                  25                  30          


Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 
        35                  40                  45              


Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 
    50                  55                  60                  


Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 
65                  70                  75                  80  


Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Asp Pro Glu 
                85                  90                  95      


Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 
            100                 105                 110         


Met Val Asp Arg Asn Asn Ala Ile Tyr Glu Lys Thr Lys Asp Ile Ser 
        115                 120                 125             


His Ser Ile Tyr Met Phe Phe Asn Thr Ser Asp Ile Arg Glu Ala Val 
    130                 135                 140                 


Pro Glu Pro Pro Leu Leu Ser Arg Ala Glu Leu Arg Leu Gln Arg Leu 
145                 150                 155                 160 


Lys Ser Ser Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 
                165                 170                 175     


Asn Ser Trp Arg Tyr Leu Gly Asn Arg Leu Leu Thr Pro Thr Asp Thr 
            180                 185                 190         


Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 
        195                 200                 205             


Asn Gln Gly Asp Gly Ile Gln Gly Phe Arg Phe Ser Ala His Cys Ser 
    210                 215                 220                 


Cys Asp Ser Lys Asp Asn Lys Leu His Val Glu Ile Asn Gly Ile Ser 
225                 230                 235                 240 


Pro Lys Arg Arg Gly Asp Leu Gly Thr Ile His Asp Met Asn Arg Pro 
                245                 250                 255     


Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu His 
            260                 265                 270         


Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 
        275                 280                 285             


Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 
    290                 295                 300                 


Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 
305                 310                 315                 320 


Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 
                325                 330                 335     


Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 
            340                 345                 350         


Ser Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 
        355                 360                 365             


Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 
    370                 375                 380                 


Arg Ser Cys Lys Cys Ser 
385                 390 


<210>  194
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  194

Met His Tyr Cys Val Leu Ser Ala Phe Leu Ile Leu His Leu Val Thr 
1               5                   10                  15      


Val Ala Leu Ser Leu Ser Thr Cys Ser Thr Leu Asp Met Asp Gln Phe 
            20                  25                  30          


Met Arg Lys Arg Ile Glu Ala Ile Arg Gly Gln Ile Leu Ser Lys Leu 
        35                  40                  45              


Lys Leu Thr Ser Pro Pro Glu Asp Tyr Pro Glu Pro Glu Glu Val Pro 
    50                  55                  60                  


Pro Glu Val Ile Ser Ile Tyr Asn Ser Thr Arg Asp Leu Leu Gln Glu 
65                  70                  75                  80  


Lys Ala Ser Arg Arg Ala Ala Ala Cys Glu Arg Glu Arg Ser Asp Glu 
                85                  90                  95      


Glu Tyr Tyr Ala Lys Glu Val Tyr Lys Ile Asp Met Pro Pro Phe Phe 
            100                 105                 110         


Pro Ser Glu Asn Ala Ile Pro Pro Thr Phe Tyr Arg Pro Tyr Phe Arg 
        115                 120                 125             


Ile Val Arg Phe Asp Val Ser Ala Met Glu Lys Asn Ala Ser Asn Leu 
    130                 135                 140                 


Val Lys Ala Glu Phe Arg Val Phe Arg Leu Gln Asn Pro Lys Ala Arg 
145                 150                 155                 160 


Val Pro Glu Gln Arg Ile Glu Leu Tyr Gln Ile Leu Lys Ser Lys Asp 
                165                 170                 175     


Leu Thr Ser Pro Thr Gln Arg Tyr Ile Asp Ser Lys Val Val Lys Thr 
            180                 185                 190         


Arg Ala Glu Gly Glu Trp Leu Ser Phe Asp Val Thr Asp Ala Val His 
        195                 200                 205             


Glu Trp Leu His His Lys Asp Arg Asn Leu Gly Phe Lys Ile Ser Leu 
    210                 215                 220                 


His Cys Pro Cys Cys Thr Phe Val Pro Ser Asn Asn Tyr Ile Ile Pro 
225                 230                 235                 240 


Asn Lys Ser Glu Glu Leu Glu Ala Arg Phe Ala Gly Ile Asp Gly Thr 
                245                 250                 255     


Ser Thr Tyr Thr Ser Gly Asp Gln Lys Thr Ile Lys Ser Thr Arg Lys 
            260                 265                 270         


Lys Asn Ser Gly Lys Thr Pro His Leu Leu Leu Met Leu Leu Pro Ser 
        275                 280                 285             


Tyr Arg Leu Glu Ser Gln Gln Thr Asn Arg Arg Lys Lys Arg Ala Leu 
    290                 295                 300                 


Asp Ala Ala Tyr Cys Phe Arg Asn Val Gln Asp Asn Cys Cys Leu Arg 
305                 310                 315                 320 


Pro Leu Tyr Ile Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp Ile His 
                325                 330                 335     


Glu Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys Pro Tyr 
            340                 345                 350         


Leu Trp Ser Ser Asp Thr Gln His Ser Arg Val Leu Ser Leu Tyr Asn 
        355                 360                 365             


Thr Ile Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Ser Gln Asp 
    370                 375                 380                 


Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro Lys Ile 
385                 390                 395                 400 


Glu Gln Leu Ser Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
                405                 410                 


<210>  195
<211>  414
<212>  PRT
<213>  Mus musculus

<400>  195

Met His Tyr Cys Val Leu Ser Thr Phe Leu Leu Leu His Leu Val Pro 
1               5                   10                  15      


Val Ala Leu Ser Leu Ser Thr Cys Ser Thr Leu Asp Met Asp Gln Phe 
            20                  25                  30          


Met Arg Lys Arg Ile Glu Ala Ile Arg Gly Gln Ile Leu Ser Lys Leu 
        35                  40                  45              


Lys Leu Thr Ser Pro Pro Glu Asp Tyr Pro Glu Pro Asp Glu Val Pro 
    50                  55                  60                  


Pro Glu Val Ile Ser Ile Tyr Asn Ser Thr Arg Asp Leu Leu Gln Glu 
65                  70                  75                  80  


Lys Ala Ser Arg Arg Ala Ala Ala Cys Glu Arg Glu Arg Ser Asp Glu 
                85                  90                  95      


Glu Tyr Tyr Ala Lys Glu Val Tyr Lys Ile Asp Met Pro Ser His Leu 
            100                 105                 110         


Pro Ser Glu Asn Ala Ile Pro Pro Thr Phe Tyr Arg Pro Tyr Phe Arg 
        115                 120                 125             


Ile Val Arg Phe Asp Val Ser Thr Met Glu Lys Asn Ala Ser Asn Leu 
    130                 135                 140                 


Val Lys Ala Glu Phe Arg Val Phe Arg Leu Gln Asn Pro Lys Ala Arg 
145                 150                 155                 160 


Val Ala Glu Gln Arg Ile Glu Leu Tyr Gln Ile Leu Lys Ser Lys Asp 
                165                 170                 175     


Leu Thr Ser Pro Thr Gln Arg Tyr Ile Asp Ser Lys Val Val Lys Thr 
            180                 185                 190         


Arg Ala Glu Gly Glu Trp Leu Ser Phe Asp Val Thr Asp Ala Val Gln 
        195                 200                 205             


Glu Trp Leu His His Lys Asp Arg Asn Leu Gly Phe Lys Ile Ser Leu 
    210                 215                 220                 


His Cys Pro Cys Cys Thr Phe Val Pro Ser Asn Asn Tyr Ile Ile Pro 
225                 230                 235                 240 


Asn Lys Ser Glu Glu Leu Glu Ala Arg Phe Ala Gly Ile Asp Gly Thr 
                245                 250                 255     


Ser Thr Tyr Ala Ser Gly Asp Gln Lys Thr Ile Lys Ser Thr Arg Lys 
            260                 265                 270         


Lys Thr Ser Gly Lys Thr Pro His Leu Leu Leu Met Leu Leu Pro Ser 
        275                 280                 285             


Tyr Arg Leu Glu Ser Gln Gln Ser Ser Arg Arg Lys Lys Arg Ala Leu 
    290                 295                 300                 


Asp Ala Ala Tyr Cys Phe Arg Asn Val Gln Asp Asn Cys Cys Leu Arg 
305                 310                 315                 320 


Pro Leu Tyr Ile Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp Ile His 
                325                 330                 335     


Glu Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys Pro Tyr 
            340                 345                 350         


Leu Trp Ser Ser Asp Thr Gln His Thr Lys Val Leu Ser Leu Tyr Asn 
        355                 360                 365             


Thr Ile Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Ser Gln Asp 
    370                 375                 380                 


Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Ile Gly Asn Thr Pro Lys Ile 
385                 390                 395                 400 


Glu Gln Leu Ser Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
                405                 410                 


<210>  196
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  196

Met Lys Met His Leu Gln Arg Ala Leu Val Val Leu Ala Leu Leu Asn 
1               5                   10                  15      


Phe Ala Thr Val Ser Leu Ser Leu Ser Thr Cys Thr Thr Leu Asp Phe 
            20                  25                  30          


Gly His Ile Lys Lys Lys Arg Val Glu Ala Ile Arg Gly Gln Ile Leu 
        35                  40                  45              


Ser Lys Leu Arg Leu Thr Ser Pro Pro Glu Pro Thr Val Met Thr His 
    50                  55                  60                  


Val Pro Tyr Gln Val Leu Ala Leu Tyr Asn Ser Thr Arg Glu Leu Leu 
65                  70                  75                  80  


Glu Glu Met His Gly Glu Arg Glu Glu Gly Cys Thr Gln Glu Asn Thr 
                85                  90                  95      


Glu Ser Glu Tyr Tyr Ala Lys Glu Ile His Lys Phe Asp Met Ile Gln 
            100                 105                 110         


Gly Leu Ala Glu His Asn Glu Leu Ala Val Cys Pro Lys Gly Ile Thr 
        115                 120                 125             


Ser Lys Val Phe Arg Phe Asn Val Ser Ser Val Glu Lys Asn Arg Thr 
    130                 135                 140                 


Asn Leu Phe Arg Ala Glu Phe Arg Val Leu Arg Val Pro Asn Pro Ser 
145                 150                 155                 160 


Ser Lys Arg Asn Glu Gln Arg Ile Glu Leu Phe Gln Ile Leu Arg Pro 
                165                 170                 175     


Asp Glu His Ile Ala Lys Gln Arg Tyr Ile Gly Gly Lys Asn Leu Pro 
            180                 185                 190         


Thr Arg Gly Thr Ala Glu Trp Leu Ser Phe Asp Val Thr Asp Thr Val 
        195                 200                 205             


Arg Glu Trp Leu Leu Arg Arg Glu Ser Asn Leu Gly Leu Glu Ile Ser 
    210                 215                 220                 


Ile His Cys Pro Cys His Thr Phe Gln Pro Asn Gly Asp Ile Leu Glu 
225                 230                 235                 240 


Asn Ile His Glu Val Met Glu Ile Lys Phe Lys Gly Val Asp Asn Glu 
                245                 250                 255     


Asp Asp His Gly Arg Gly Asp Leu Gly Arg Leu Lys Lys Gln Lys Asp 
            260                 265                 270         


His His Asn Pro His Leu Ile Leu Met Met Ile Pro Pro His Arg Leu 
        275                 280                 285             


Asp Asn Pro Gly Gln Gly Gly Gln Arg Lys Lys Arg Ala Leu Asp Thr 
    290                 295                 300                 


Asn Tyr Cys Phe Arg Asn Leu Glu Glu Asn Cys Cys Val Arg Pro Leu 
305                 310                 315                 320 


Tyr Ile Asp Phe Arg Gln Asp Leu Gly Trp Lys Trp Val His Glu Pro 
                325                 330                 335     


Lys Gly Tyr Tyr Ala Asn Phe Cys Ser Gly Pro Cys Pro Tyr Leu Arg 
            340                 345                 350         


Ser Ala Asp Thr Thr His Ser Thr Val Leu Gly Leu Tyr Asn Thr Leu 
        355                 360                 365             


Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Pro Gln Asp Leu Glu 
    370                 375                 380                 


Pro Leu Thr Ile Leu Tyr Tyr Val Gly Arg Thr Pro Lys Val Glu Gln 
385                 390                 395                 400 


Leu Ser Asn Met Val Val Lys Ser Cys Lys Cys Ser 
                405                 410         


<210>  197
<211>  410
<212>  PRT
<213>  Mus musculus

<400>  197

Met His Leu Gln Arg Ala Leu Val Val Leu Ala Leu Leu Asn Leu Ala 
1               5                   10                  15      


Thr Ile Ser Leu Ser Leu Ser Thr Cys Thr Thr Leu Asp Phe Gly His 
            20                  25                  30          


Ile Lys Lys Lys Arg Val Glu Ala Ile Arg Gly Gln Ile Leu Ser Lys 
        35                  40                  45              


Leu Arg Leu Thr Ser Pro Pro Glu Pro Ser Val Met Thr His Val Pro 
    50                  55                  60                  


Tyr Gln Val Leu Ala Leu Tyr Asn Ser Thr Arg Glu Leu Leu Glu Glu 
65                  70                  75                  80  


Met His Gly Glu Arg Glu Glu Gly Cys Thr Gln Glu Thr Ser Glu Ser 
                85                  90                  95      


Glu Tyr Tyr Ala Lys Glu Ile His Lys Phe Asp Met Ile Gln Gly Leu 
            100                 105                 110         


Ala Glu His Asn Glu Leu Ala Val Cys Pro Lys Gly Ile Thr Ser Lys 
        115                 120                 125             


Val Phe Arg Phe Asn Val Ser Ser Val Glu Lys Asn Gly Thr Asn Leu 
    130                 135                 140                 


Phe Arg Ala Glu Phe Arg Val Leu Arg Val Pro Asn Pro Ser Ser Lys 
145                 150                 155                 160 


Arg Thr Glu Gln Arg Ile Glu Leu Phe Gln Ile Leu Arg Pro Asp Glu 
                165                 170                 175     


His Ile Ala Lys Gln Arg Tyr Ile Gly Gly Lys Asn Leu Pro Thr Arg 
            180                 185                 190         


Gly Thr Ala Glu Trp Leu Ser Phe Asp Val Thr Asp Thr Val Arg Glu 
        195                 200                 205             


Trp Leu Leu Arg Arg Glu Ser Asn Leu Gly Leu Glu Ile Ser Ile His 
    210                 215                 220                 


Cys Pro Cys His Thr Phe Gln Pro Asn Gly Asp Ile Leu Glu Asn Val 
225                 230                 235                 240 


His Glu Val Met Glu Ile Lys Phe Lys Gly Val Asp Asn Glu Asp Asp 
                245                 250                 255     


His Gly Arg Gly Asp Leu Gly Arg Leu Lys Lys Gln Lys Asp His His 
            260                 265                 270         


Asn Pro His Leu Ile Leu Met Met Ile Pro Pro His Arg Leu Asp Ser 
        275                 280                 285             


Pro Gly Gln Gly Ser Gln Arg Lys Lys Arg Ala Leu Asp Thr Asn Tyr 
    290                 295                 300                 


Cys Phe Arg Asn Leu Glu Glu Asn Cys Cys Val Arg Pro Leu Tyr Ile 
305                 310                 315                 320 


Asp Phe Arg Gln Asp Leu Gly Trp Lys Trp Val His Glu Pro Lys Gly 
                325                 330                 335     


Tyr Tyr Ala Asn Phe Cys Ser Gly Pro Cys Pro Tyr Leu Arg Ser Ala 
            340                 345                 350         


Asp Thr Thr His Ser Thr Val Leu Gly Leu Tyr Asn Thr Leu Asn Pro 
        355                 360                 365             


Glu Ala Ser Ala Ser Pro Cys Cys Val Pro Gln Asp Leu Glu Pro Leu 
    370                 375                 380                 


Thr Ile Leu Tyr Tyr Val Gly Arg Thr Pro Lys Val Glu Gln Leu Ser 
385                 390                 395                 400 


Asn Met Val Val Lys Ser Cys Lys Cys Ser 
                405                 410 


<210>  198
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  198

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu 
            20                  25                  30          


Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu Leu Glu Ala Lys Glu 
        35                  40                  45              


Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His Cys Ser Leu Asn Glu 
    50                  55                  60                  


Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Ala Trp Lys Arg 
65                  70                  75                  80  


Met Glu Val Gly Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu 
                85                  90                  95      


Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu Leu Val Asn Ser Ser 
            100                 105                 110         


Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp Lys Ala Val Ser Gly 
        115                 120                 125             


Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu 
    130                 135                 140                 


Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala Pro Leu Arg Thr Ile 
145                 150                 155                 160 


Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val Tyr Ser Asn Phe Leu 
                165                 170                 175     


Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala Cys Arg Thr Gly Asp 
            180                 185                 190         


Arg 
    


<210>  199
<211>  192
<212>  PRT
<213>  Mus musculus

<400>  199

Met Gly Val Pro Glu Arg Pro Thr Leu Leu Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Leu Ile Pro Leu Gly Leu Pro Val Leu Cys Ala Pro Pro Arg Leu Ile 
            20                  25                  30          


Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile Leu Glu Ala Lys Glu Ala 
        35                  40                  45              


Glu Asn Val Thr Met Gly Cys Ala Glu Gly Pro Arg Leu Ser Glu Asn 
    50                  55                  60                  


Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Ala Trp Lys Arg Met 
65                  70                  75                  80  


Glu Val Glu Glu Gln Ala Ile Glu Val Trp Gln Gly Leu Ser Leu Leu 
                85                  90                  95      


Ser Glu Ala Ile Leu Gln Ala Gln Ala Leu Leu Ala Asn Ser Ser Gln 
            100                 105                 110         


Pro Pro Glu Thr Leu Gln Leu His Ile Asp Lys Ala Ile Ser Gly Leu 
        115                 120                 125             


Arg Ser Leu Thr Ser Leu Leu Arg Val Leu Gly Ala Gln Lys Glu Leu 
    130                 135                 140                 


Met Ser Pro Pro Asp Thr Thr Pro Pro Ala Pro Leu Arg Thr Leu Thr 
145                 150                 155                 160 


Val Asp Thr Phe Cys Lys Leu Phe Arg Val Tyr Ala Asn Phe Leu Arg 
                165                 170                 175     


Gly Lys Leu Lys Leu Tyr Thr Gly Glu Val Cys Arg Arg Gly Asp Arg 
            180                 185                 190         


<210>  200
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  200

Met Glu Leu Thr Glu Leu Leu Leu Val Val Met Leu Leu Leu Thr Ala 
1               5                   10                  15      


Arg Leu Thr Leu Ser Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val 
            20                  25                  30          


Leu Ser Lys Leu Leu Arg Asp Ser His Val Leu His Ser Arg Leu Ser 
        35                  40                  45              


Gln Cys Pro Glu Val His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala 
    50                  55                  60                  


Val Asp Phe Ser Leu Gly Glu Trp Lys Thr Gln Met Glu Glu Thr Lys 
65                  70                  75                  80  


Ala Gln Asp Ile Leu Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met 
                85                  90                  95      


Ala Ala Arg Gly Gln Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly 
            100                 105                 110         


Gln Leu Ser Gly Gln Val Arg Leu Leu Leu Gly Ala Leu Gln Ser Leu 
        115                 120                 125             


Leu Gly Thr Gln Leu Pro Pro Gln Gly Arg Thr Thr Ala His Lys Asp 
    130                 135                 140                 


Pro Asn Ala Ile Phe Leu Ser Phe Gln His Leu Leu Arg Gly Lys Val 
145                 150                 155                 160 


Arg Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val Arg Arg Ala 
                165                 170                 175     


Pro Pro Thr Thr Ala Val Pro Ser Arg Thr Ser Leu Val Leu Thr Leu 
            180                 185                 190         


Asn Glu Leu Pro Asn Arg Thr Ser Gly Leu Leu Glu Thr Asn Phe Thr 
        195                 200                 205             


Ala Ser Ala Arg Thr Thr Gly Ser Gly Leu Leu Lys Trp Gln Gln Gly 
    210                 215                 220                 


Phe Arg Ala Lys Ile Pro Gly Leu Leu Asn Gln Thr Ser Arg Ser Leu 
225                 230                 235                 240 


Asp Gln Ile Pro Gly Tyr Leu Asn Arg Ile His Glu Leu Leu Asn Gly 
                245                 250                 255     


Thr Arg Gly Leu Phe Pro Gly Pro Ser Arg Arg Thr Leu Gly Ala Pro 
            260                 265                 270         


Asp Ile Ser Ser Gly Thr Ser Asp Thr Gly Ser Leu Pro Pro Asn Leu 
        275                 280                 285             


Gln Pro Gly Tyr Ser Pro Ser Pro Thr His Pro Pro Thr Gly Gln Tyr 
    290                 295                 300                 


Thr Leu Phe Pro Leu Pro Pro Thr Leu Pro Thr Pro Val Val Gln Leu 
305                 310                 315                 320 


His Pro Leu Leu Pro Asp Pro Ser Ala Pro Thr Pro Thr Pro Thr Ser 
                325                 330                 335     


Pro Leu Leu Asn Thr Ser Tyr Thr His Ser Gln Asn Leu Ser Gln Glu 
            340                 345                 350         


Gly 
    


<210>  201
<211>  356
<212>  PRT
<213>  Mus musculus

<400>  201

Met Glu Leu Thr Asp Leu Leu Leu Ala Ala Met Leu Leu Ala Val Ala 
1               5                   10                  15      


Arg Leu Thr Leu Ser Ser Pro Val Ala Pro Ala Cys Asp Pro Arg Leu 
            20                  25                  30          


Leu Asn Lys Leu Leu Arg Asp Ser His Leu Leu His Ser Arg Leu Ser 
        35                  40                  45              


Gln Cys Pro Asp Val Asp Pro Leu Ser Ile Pro Val Leu Leu Pro Ala 
    50                  55                  60                  


Val Asp Phe Ser Leu Gly Glu Trp Lys Thr Gln Thr Glu Gln Ser Lys 
65                  70                  75                  80  


Ala Gln Asp Ile Leu Gly Ala Val Ser Leu Leu Leu Glu Gly Val Met 
                85                  90                  95      


Ala Ala Arg Gly Gln Leu Glu Pro Ser Cys Leu Ser Ser Leu Leu Gly 
            100                 105                 110         


Gln Leu Ser Gly Gln Val Arg Leu Leu Leu Gly Ala Leu Gln Gly Leu 
        115                 120                 125             


Leu Gly Thr Gln Leu Pro Leu Gln Gly Arg Thr Thr Ala His Lys Asp 
    130                 135                 140                 


Pro Asn Ala Leu Phe Leu Ser Leu Gln Gln Leu Leu Arg Gly Lys Val 
145                 150                 155                 160 


Arg Phe Leu Leu Leu Val Glu Gly Pro Thr Leu Cys Val Arg Arg Thr 
                165                 170                 175     


Leu Pro Thr Thr Ala Val Pro Ser Ser Thr Ser Gln Leu Leu Thr Leu 
            180                 185                 190         


Asn Lys Phe Pro Asn Arg Thr Ser Gly Leu Leu Glu Thr Asn Phe Ser 
        195                 200                 205             


Val Thr Ala Arg Thr Ala Gly Pro Gly Leu Leu Ser Arg Leu Gln Gly 
    210                 215                 220                 


Phe Arg Val Lys Ile Thr Pro Gly Gln Leu Asn Gln Thr Ser Arg Ser 
225                 230                 235                 240 


Pro Val Gln Ile Ser Gly Tyr Leu Asn Arg Thr His Gly Pro Val Asn 
                245                 250                 255     


Gly Thr His Gly Leu Phe Ala Gly Thr Ser Leu Gln Thr Leu Glu Ala 
            260                 265                 270         


Ser Asp Ile Ser Pro Gly Ala Phe Asn Lys Gly Ser Leu Ala Phe Asn 
        275                 280                 285             


Leu Gln Gly Gly Leu Pro Pro Ser Pro Ser Leu Ala Pro Asp Gly His 
    290                 295                 300                 


Thr Pro Phe Pro Pro Ser Pro Ala Leu Pro Thr Thr His Gly Ser Pro 
305                 310                 315                 320 


Pro Gln Leu His Pro Leu Phe Pro Asp Pro Ser Thr Thr Met Pro Asn 
                325                 330                 335     


Ser Thr Ala Pro His Pro Val Thr Met Tyr Pro His Pro Arg Asn Leu 
            340                 345                 350         


Ser Gln Glu Thr 
        355     


<210>  202
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  202

Met Thr Val Leu Ala Pro Ala Trp Ser Pro Thr Thr Tyr Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ser Gly Leu Ser Gly Thr Gln Asp Cys Ser Phe 
            20                  25                  30          


Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 
        35                  40                  45              


Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 
    50                  55                  60                  


Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 
65                  70                  75                  80  


Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 
                85                  90                  95      


Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 
            100                 105                 110         


Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 
        115                 120                 125             


Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 
    130                 135                 140                 


Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala 
                165                 170                 175     


Thr Ala Pro Thr Ala Pro Gln Pro Pro Leu Leu Leu Leu Leu Leu Leu 
            180                 185                 190         


Pro Val Gly Leu Leu Leu Leu Ala Ala Ala Trp Cys Leu His Trp Gln 
        195                 200                 205             


Arg Thr Arg Arg Arg Thr Pro Arg Pro Gly Glu Gln Val Pro Pro Val 
    210                 215                 220                 


Pro Ser Pro Gln Asp Leu Leu Leu Val Glu His 
225                 230                 235 


<210>  203
<211>  232
<212>  PRT
<213>  Mus musculus

<400>  203

Met Thr Val Leu Ala Pro Ala Trp Ser Pro Asn Ser Ser Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ser Pro Cys Leu Arg Gly Thr Pro Asp Cys Tyr 
            20                  25                  30          


Phe Ser His Ser Pro Ile Ser Ser Asn Phe Lys Val Lys Phe Arg Glu 
        35                  40                  45              


Leu Thr Asp His Leu Leu Lys Asp Tyr Pro Val Thr Val Ala Val Asn 
    50                  55                  60                  


Leu Gln Asp Glu Lys His Cys Lys Ala Leu Trp Ser Leu Phe Leu Ala 
65                  70                  75                  80  


Gln Arg Trp Ile Glu Gln Leu Lys Thr Val Ala Gly Ser Lys Met Gln 
                85                  90                  95      


Thr Leu Leu Glu Asp Val Asn Thr Glu Ile His Phe Val Thr Ser Cys 
            100                 105                 110         


Thr Phe Gln Pro Leu Pro Glu Cys Leu Arg Phe Val Gln Thr Asn Ile 
        115                 120                 125             


Ser His Leu Leu Lys Asp Thr Cys Thr Gln Leu Leu Ala Leu Lys Pro 
    130                 135                 140                 


Cys Ile Gly Lys Ala Cys Gln Asn Phe Ser Arg Cys Leu Glu Val Gln 
145                 150                 155                 160 


Cys Gln Pro Asp Ser Ser Thr Leu Leu Pro Pro Arg Ser Pro Ile Ala 
                165                 170                 175     


Leu Glu Ala Thr Glu Leu Pro Glu Pro Arg Pro Arg Gln Leu Leu Leu 
            180                 185                 190         


Leu Leu Leu Leu Leu Leu Pro Leu Thr Leu Val Leu Leu Ala Ala Ala 
        195                 200                 205             


Trp Gly Leu Arg Trp Gln Arg Ala Arg Arg Arg Gly Glu Leu His Pro 
    210                 215                 220                 


Gly Val Pro Leu Pro Ser His Pro 
225                 230         


<210>  204
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  204

Met Lys Lys Thr Gln Thr Trp Ile Leu Thr Cys Ile Tyr Leu Gln Leu 
1               5                   10                  15      


Leu Leu Phe Asn Pro Leu Val Lys Thr Glu Gly Ile Cys Arg Asn Arg 
            20                  25                  30          


Val Thr Asn Asn Val Lys Asp Val Thr Lys Leu Val Ala Asn Leu Pro 
        35                  40                  45              


Lys Asp Tyr Met Ile Thr Leu Lys Tyr Val Pro Gly Met Asp Val Leu 
    50                  55                  60                  


Pro Ser His Cys Trp Ile Ser Glu Met Val Val Gln Leu Ser Asp Ser 
65                  70                  75                  80  


Leu Thr Asp Leu Leu Asp Lys Phe Ser Asn Ile Ser Glu Gly Leu Ser 
                85                  90                  95      


Asn Tyr Ser Ile Ile Asp Lys Leu Val Asn Ile Val Asp Asp Leu Val 
            100                 105                 110         


Glu Cys Val Lys Glu Asn Ser Ser Lys Asp Leu Lys Lys Ser Phe Lys 
        115                 120                 125             


Ser Pro Glu Pro Arg Leu Phe Thr Pro Glu Glu Phe Phe Arg Ile Phe 
    130                 135                 140                 


Asn Arg Ser Ile Asp Ala Phe Lys Asp Phe Val Val Ala Ser Glu Thr 
145                 150                 155                 160 


Ser Asp Cys Val Val Ser Ser Thr Leu Ser Pro Glu Lys Asp Ser Arg 
                165                 170                 175     


Val Ser Val Thr Lys Pro Phe Met Leu Pro Pro Val Ala Ala Ser Ser 
            180                 185                 190         


Leu Arg Asn Asp Ser Ser Ser Ser Asn Arg Lys Ala Lys Asn Pro Pro 
        195                 200                 205             


Gly Asp Ser Ser Leu His Trp Ala Ala Met Ala Leu Pro Ala Leu Phe 
    210                 215                 220                 


Ser Leu Ile Ile Gly Phe Ala Phe Gly Ala Leu Tyr Trp Lys Lys Arg 
225                 230                 235                 240 


Gln Pro Ser Leu Thr Arg Ala Val Glu Asn Ile Gln Ile Asn Glu Glu 
                245                 250                 255     


Asp Asn Glu Ile Ser Met Leu Gln Glu Lys Glu Arg Glu Phe Gln Glu 
            260                 265                 270         


Val 
    


<210>  205
<211>  273
<212>  PRT
<213>  Mus musculus

<400>  205

Met Lys Lys Thr Gln Thr Trp Ile Ile Thr Cys Ile Tyr Leu Gln Leu 
1               5                   10                  15      


Leu Leu Phe Asn Pro Leu Val Lys Thr Lys Glu Ile Cys Gly Asn Pro 
            20                  25                  30          


Val Thr Asp Asn Val Lys Asp Ile Thr Lys Leu Val Ala Asn Leu Pro 
        35                  40                  45              


Asn Asp Tyr Met Ile Thr Leu Asn Tyr Val Ala Gly Met Asp Val Leu 
    50                  55                  60                  


Pro Ser His Cys Trp Leu Arg Asp Met Val Ile Gln Leu Ser Leu Ser 
65                  70                  75                  80  


Leu Thr Thr Leu Leu Asp Lys Phe Ser Asn Ile Ser Glu Gly Leu Ser 
                85                  90                  95      


Asn Tyr Ser Ile Ile Asp Lys Leu Gly Lys Ile Val Asp Asp Leu Val 
            100                 105                 110         


Leu Cys Met Glu Glu Asn Ala Pro Lys Asn Ile Lys Glu Ser Pro Lys 
        115                 120                 125             


Arg Pro Glu Thr Arg Ser Phe Thr Pro Glu Glu Phe Phe Ser Ile Phe 
    130                 135                 140                 


Asn Arg Ser Ile Asp Ala Phe Lys Asp Phe Met Val Ala Ser Asp Thr 
145                 150                 155                 160 


Ser Asp Cys Val Leu Ser Ser Thr Leu Gly Pro Glu Lys Asp Ser Arg 
                165                 170                 175     


Val Ser Val Thr Lys Pro Phe Met Leu Pro Pro Val Ala Ala Ser Ser 
            180                 185                 190         


Leu Arg Asn Asp Ser Ser Ser Ser Asn Arg Lys Ala Ala Lys Ala Pro 
        195                 200                 205             


Glu Asp Ser Gly Leu Gln Trp Thr Ala Met Ala Leu Pro Ala Leu Ile 
    210                 215                 220                 


Ser Leu Val Ile Gly Phe Ala Phe Gly Ala Leu Tyr Trp Lys Lys Lys 
225                 230                 235                 240 


Gln Ser Ser Leu Thr Arg Ala Val Glu Asn Ile Gln Ile Asn Glu Glu 
                245                 250                 255     


Asp Asn Glu Ile Ser Met Leu Gln Gln Lys Glu Arg Glu Phe Gln Glu 
            260                 265                 270         


Val 
    


<210>  206
<211>  554
<212>  PRT
<213>  Homo sapiens

<400>  206

Met Thr Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Thr Thr Trp Leu 
1               5                   10                  15      


Gly Ser Leu Leu Leu Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Thr 
            20                  25                  30          


Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
        35                  40                  45              


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 
    50                  55                  60                  


Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
65                  70                  75                  80  


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
                85                  90                  95      


Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 
            100                 105                 110         


Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu 
        115                 120                 125             


Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln 
    130                 135                 140                 


Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 
145                 150                 155                 160 


Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 
                165                 170                 175     


Glu Cys Ser Ser Gln Asp Val Val Thr Lys Pro Asp Cys Asn Cys Leu 
            180                 185                 190         


Tyr Pro Lys Ala Ile Pro Ser Ser Asp Pro Ala Ser Val Ser Pro His 
        195                 200                 205             


Gln Pro Leu Ala Pro Ser Met Ala Pro Val Ala Gly Leu Thr Trp Glu 
    210                 215                 220                 


Asp Ser Glu Gly Thr Glu Gly Ser Ser Leu Leu Pro Gly Glu Gln Pro 
225                 230                 235                 240 


Leu His Thr Val Asp Pro Gly Ser Ala Lys Gln Arg Pro Pro Arg Ser 
                245                 250                 255     


Thr Cys Gln Ser Phe Glu Pro Pro Glu Thr Pro Val Val Lys Asp Ser 
            260                 265                 270         


Thr Ile Gly Gly Ser Pro Gln Pro Arg Pro Ser Val Gly Ala Phe Asn 
        275                 280                 285             


Pro Gly Met Glu Asp Ile Leu Asp Ser Ala Met Gly Thr Asn Trp Val 
    290                 295                 300                 


Pro Glu Glu Ala Ser Gly Glu Ala Ser Glu Ile Pro Val Pro Gln Gly 
305                 310                 315                 320 


Thr Glu Leu Ser Pro Ser Arg Pro Gly Gly Gly Ser Met Gln Thr Glu 
                325                 330                 335     


Pro Ala Arg Pro Ser Asn Phe Leu Ser Ala Ser Ser Pro Leu Pro Ala 
            340                 345                 350         


Ser Ala Lys Gly Gln Gln Pro Ala Asp Val Thr Gly Thr Ala Leu Pro 
        355                 360                 365             


Arg Val Gly Pro Val Arg Pro Thr Gly Gln Asp Trp Asn His Thr Pro 
    370                 375                 380                 


Gln Lys Thr Asp His Pro Ser Ala Leu Leu Arg Asp Pro Pro Glu Pro 
385                 390                 395                 400 


Gly Ser Pro Arg Ile Ser Ser Leu Arg Pro Gln Gly Leu Ser Asn Pro 
                405                 410                 415     


Ser Thr Leu Ser Ala Gln Pro Gln Leu Ser Arg Ser His Ser Ser Gly 
            420                 425                 430         


Ser Val Leu Pro Leu Gly Glu Leu Glu Gly Arg Arg Ser Thr Arg Asp 
        435                 440                 445             


Arg Arg Ser Pro Ala Glu Pro Glu Gly Gly Pro Ala Ser Glu Gly Ala 
    450                 455                 460                 


Ala Arg Pro Leu Pro Arg Phe Asn Ser Val Pro Leu Thr Asp Thr Gly 
465                 470                 475                 480 


His Glu Arg Gln Ser Glu Gly Ser Phe Ser Pro Gln Leu Gln Glu Ser 
                485                 490                 495     


Val Phe His Leu Leu Val Pro Ser Val Ile Leu Val Leu Leu Ala Val 
            500                 505                 510         


Gly Gly Leu Leu Phe Tyr Arg Trp Arg Arg Arg Ser His Gln Glu Pro 
        515                 520                 525             


Gln Arg Ala Asp Ser Pro Leu Glu Gln Pro Glu Gly Ser Pro Leu Thr 
    530                 535                 540                 


Gln Asp Asp Arg Gln Val Glu Leu Pro Val 
545                 550                 


<210>  207
<211>  552
<212>  PRT
<213>  Mus musculus

<400>  207

Met Thr Ala Arg Gly Ala Ala Gly Arg Cys Pro Ser Ser Thr Trp Leu 
1               5                   10                  15      


Gly Ser Arg Leu Leu Leu Val Cys Leu Leu Met Ser Arg Ser Ile Ala 
            20                  25                  30          


Lys Glu Val Ser Glu His Cys Ser His Met Ile Gly Asn Gly His Leu 
        35                  40                  45              


Lys Val Leu Gln Gln Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 
    50                  55                  60                  


Ile Ala Phe Glu Phe Val Asp Gln Glu Gln Leu Asp Asp Pro Val Cys 
65                  70                  75                  80  


Tyr Leu Lys Lys Ala Phe Phe Leu Val Gln Asp Ile Ile Asp Glu Thr 
                85                  90                  95      


Met Arg Phe Lys Asp Asn Thr Pro Asn Ala Asn Ala Thr Glu Arg Leu 
            100                 105                 110         


Gln Glu Leu Ser Asn Asn Leu Asn Ser Cys Phe Thr Lys Asp Tyr Glu 
        115                 120                 125             


Glu Gln Asn Lys Ala Cys Val Arg Thr Phe His Glu Thr Pro Leu Gln 
    130                 135                 140                 


Leu Leu Glu Lys Ile Lys Asn Phe Phe Asn Glu Thr Lys Asn Leu Leu 
145                 150                 155                 160 


Glu Lys Asp Trp Asn Ile Phe Thr Lys Asn Cys Asn Asn Ser Phe Ala 
                165                 170                 175     


Lys Cys Ser Ser Arg Asp Val Val Thr Lys Pro Asp Cys Asn Cys Leu 
            180                 185                 190         


Tyr Pro Lys Ala Thr Pro Ser Ser Asp Pro Ala Ser Ala Ser Pro His 
        195                 200                 205             


Gln Pro Pro Ala Pro Ser Met Ala Pro Leu Ala Gly Leu Ala Trp Asp 
    210                 215                 220                 


Asp Ser Gln Arg Thr Glu Gly Ser Ser Leu Leu Pro Ser Glu Leu Pro 
225                 230                 235                 240 


Leu Arg Ile Glu Asp Pro Gly Ser Ala Lys Gln Arg Pro Pro Arg Ser 
                245                 250                 255     


Thr Cys Gln Thr Leu Glu Ser Thr Glu Gln Pro Asn His Gly Asp Arg 
            260                 265                 270         


Leu Thr Glu Asp Ser Gln Pro His Pro Ser Ala Gly Gly Pro Val Pro 
        275                 280                 285             


Gly Val Glu Asp Ile Leu Glu Ser Ser Leu Gly Thr Asn Trp Val Leu 
    290                 295                 300                 


Glu Glu Ala Ser Gly Glu Ala Ser Glu Gly Phe Leu Thr Gln Glu Ala 
305                 310                 315                 320 


Lys Phe Ser Pro Ser Thr Pro Val Gly Gly Ser Ile Gln Ala Glu Thr 
                325                 330                 335     


Asp Arg Pro Arg Ala Leu Ser Ala Ser Pro Phe Pro Lys Ser Thr Glu 
            340                 345                 350         


Asp Gln Lys Pro Val Asp Ile Thr Asp Arg Pro Leu Thr Glu Val Asn 
        355                 360                 365             


Pro Met Arg Pro Ile Gly Gln Thr Gln Asn Asn Thr Pro Glu Lys Thr 
    370                 375                 380                 


Asp Gly Thr Ser Thr Leu Arg Glu Asp His Gln Glu Pro Gly Ser Pro 
385                 390                 395                 400 


His Ile Ala Thr Pro Asn Pro Gln Arg Val Ser Asn Ser Ala Thr Pro 
                405                 410                 415     


Val Ala Gln Leu Leu Leu Pro Lys Ser His Ser Trp Gly Ile Val Leu 
            420                 425                 430         


Pro Leu Gly Glu Leu Glu Gly Lys Arg Ser Thr Arg Asp Arg Arg Ser 
        435                 440                 445             


Pro Ala Glu Leu Glu Gly Gly Ser Ala Ser Glu Gly Ala Ala Arg Pro 
    450                 455                 460                 


Val Ala Arg Phe Asn Ser Ile Pro Leu Thr Asp Thr Gly His Val Glu 
465                 470                 475                 480 


Gln His Glu Gly Ser Ser Asp Pro Gln Ile Pro Glu Ser Val Phe His 
                485                 490                 495     


Leu Leu Val Pro Gly Ile Ile Leu Val Leu Leu Thr Val Gly Gly Leu 
            500                 505                 510         


Leu Phe Tyr Lys Trp Lys Trp Arg Ser His Arg Asp Pro Gln Thr Leu 
        515                 520                 525             


Asp Ser Ser Val Gly Arg Pro Glu Asp Ser Ser Leu Thr Gln Asp Glu 
    530                 535                 540                 


Asp Arg Gln Val Glu Leu Pro Val 
545                 550         


<210>  208
<211>  711
<212>  PRT
<213>  Homo sapiens

<400>  208

Met Gly Trp Leu Pro Leu Leu Leu Leu Leu Thr Gln Cys Leu Gly Val 
1               5                   10                  15      


Pro Gly Gln Arg Ser Pro Leu Asn Asp Phe Gln Val Leu Arg Gly Thr 
            20                  25                  30          


Glu Leu Gln His Leu Leu His Ala Val Val Pro Gly Pro Trp Gln Glu 
        35                  40                  45              


Asp Val Ala Asp Ala Glu Glu Cys Ala Gly Arg Cys Gly Pro Leu Met 
    50                  55                  60                  


Asp Cys Arg Ala Phe His Tyr Asn Val Ser Ser His Gly Cys Gln Leu 
65                  70                  75                  80  


Leu Pro Trp Thr Gln His Ser Pro His Thr Arg Leu Arg Arg Ser Gly 
                85                  90                  95      


Arg Cys Asp Leu Phe Gln Lys Lys Asp Tyr Val Arg Thr Cys Ile Met 
            100                 105                 110         


Asn Asn Gly Val Gly Tyr Arg Gly Thr Met Ala Thr Thr Val Gly Gly 
        115                 120                 125             


Leu Pro Cys Gln Ala Trp Ser His Lys Phe Pro Asn Asp His Lys Tyr 
    130                 135                 140                 


Thr Pro Thr Leu Arg Asn Gly Leu Glu Glu Asn Phe Cys Arg Asn Pro 
145                 150                 155                 160 


Asp Gly Asp Pro Gly Gly Pro Trp Cys Tyr Thr Thr Asp Pro Ala Val 
                165                 170                 175     


Arg Phe Gln Ser Cys Gly Ile Lys Ser Cys Arg Glu Ala Ala Cys Val 
            180                 185                 190         


Trp Cys Asn Gly Glu Glu Tyr Arg Gly Ala Val Asp Arg Thr Glu Ser 
        195                 200                 205             


Gly Arg Glu Cys Gln Arg Trp Asp Leu Gln His Pro His Gln His Pro 
    210                 215                 220                 


Phe Glu Pro Gly Lys Phe Leu Asp Gln Gly Leu Asp Asp Asn Tyr Cys 
225                 230                 235                 240 


Arg Asn Pro Asp Gly Ser Glu Arg Pro Trp Cys Tyr Thr Thr Asp Pro 
                245                 250                 255     


Gln Ile Glu Arg Glu Phe Cys Asp Leu Pro Arg Cys Gly Ser Glu Ala 
            260                 265                 270         


Gln Pro Arg Gln Glu Ala Thr Thr Val Ser Cys Phe Arg Gly Lys Gly 
        275                 280                 285             


Glu Gly Tyr Arg Gly Thr Ala Asn Thr Thr Thr Ala Gly Val Pro Cys 
    290                 295                 300                 


Gln Arg Trp Asp Ala Gln Ile Pro His Gln His Arg Phe Thr Pro Glu 
305                 310                 315                 320 


Lys Tyr Ala Cys Lys Asp Leu Arg Glu Asn Phe Cys Arg Asn Pro Asp 
                325                 330                 335     


Gly Ser Glu Ala Pro Trp Cys Phe Thr Leu Arg Pro Gly Met Arg Ala 
            340                 345                 350         


Ala Phe Cys Tyr Gln Ile Arg Arg Cys Thr Asp Asp Val Arg Pro Gln 
        355                 360                 365             


Asp Cys Tyr His Gly Ala Gly Glu Gln Tyr Arg Gly Thr Val Ser Lys 
    370                 375                 380                 


Thr Arg Lys Gly Val Gln Cys Gln Arg Trp Ser Ala Glu Thr Pro His 
385                 390                 395                 400 


Lys Pro Gln Phe Thr Phe Thr Ser Glu Pro His Ala Gln Leu Glu Glu 
                405                 410                 415     


Asn Phe Cys Arg Asn Pro Asp Gly Asp Ser His Gly Pro Trp Cys Tyr 
            420                 425                 430         


Thr Met Asp Pro Arg Thr Pro Phe Asp Tyr Cys Ala Leu Arg Arg Cys 
        435                 440                 445             


Ala Asp Asp Gln Pro Pro Ser Ile Leu Asp Pro Pro Asp Gln Val Gln 
    450                 455                 460                 


Phe Glu Lys Cys Gly Lys Arg Val Asp Arg Leu Asp Gln Arg Arg Ser 
465                 470                 475                 480 


Lys Leu Arg Val Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val 
                485                 490                 495     


Ser Leu Arg Asn Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val 
            500                 505                 510         


Lys Glu Gln Trp Ile Leu Thr Ala Arg Gln Cys Phe Ser Ser Cys His 
        515                 520                 525             


Met Pro Leu Thr Gly Tyr Glu Val Trp Leu Gly Thr Leu Phe Gln Asn 
    530                 535                 540                 


Pro Gln His Gly Glu Pro Ser Leu Gln Arg Val Pro Val Ala Lys Met 
545                 550                 555                 560 


Val Cys Gly Pro Ser Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg 
                565                 570                 575     


Ser Val Thr Leu Asn Gln Arg Val Ala Leu Ile Cys Leu Pro Pro Glu 
            580                 585                 590         


Trp Tyr Val Val Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly 
        595                 600                 605             


Glu Thr Lys Gly Thr Gly Asn Asp Thr Val Leu Asn Val Ala Leu Leu 
    610                 615                 620                 


Asn Val Ile Ser Asn Gln Glu Cys Asn Ile Lys His Arg Gly Arg Val 
625                 630                 635                 640 


Arg Glu Ser Glu Met Cys Thr Glu Gly Leu Leu Ala Pro Val Gly Ala 
                645                 650                 655     


Cys Glu Gly Asp Tyr Gly Gly Pro Leu Ala Cys Phe Thr His Asn Cys 
            660                 665                 670         


Trp Val Leu Glu Gly Ile Ile Ile Pro Asn Arg Val Cys Ala Arg Ser 
        675                 680                 685             


Arg Trp Pro Ala Val Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile 
    690                 695                 700                 


His Lys Val Met Arg Leu Gly 
705                 710     


<210>  209
<211>  1378
<212>  PRT
<213>  Mus musculus

<400>  209

Met Gly Leu Pro Leu Pro Leu Leu Gln Ser Ser Leu Leu Leu Met Leu 
1               5                   10                  15      


Leu Leu Arg Leu Ser Ala Ala Ser Thr Asn Leu Asn Trp Gln Cys Pro 
            20                  25                  30          


Arg Ile Pro Tyr Ala Ala Ser Arg Asp Phe Ser Val Lys Tyr Val Val 
        35                  40                  45              


Pro Ser Phe Ser Ala Gly Gly Arg Val Gln Ala Thr Ala Ala Tyr Glu 
    50                  55                  60                  


Asp Ser Thr Asn Ser Ala Val Phe Val Ala Thr Arg Asn His Leu His 
65                  70                  75                  80  


Val Leu Gly Pro Asp Leu Gln Phe Ile Glu Asn Leu Thr Thr Gly Pro 
                85                  90                  95      


Ile Gly Asn Pro Gly Cys Gln Thr Cys Ala Ser Cys Gly Pro Gly Pro 
            100                 105                 110         


His Gly Pro Pro Lys Asp Thr Asp Thr Leu Val Leu Val Met Glu Pro 
        115                 120                 125             


Gly Leu Pro Ala Leu Val Ser Cys Gly Ser Thr Leu Gln Gly Arg Cys 
    130                 135                 140                 


Phe Leu His Glu Leu Glu Pro Arg Gly Lys Ala Leu His Leu Ala Ala 
145                 150                 155                 160 


Pro Ala Cys Leu Phe Ser Ala Asn Asn Asn Lys Pro Glu Ala Cys Thr 
                165                 170                 175     


Asp Cys Val Ala Ser Pro Leu Gly Thr Arg Val Thr Val Val Glu Gln 
            180                 185                 190         


Gly His Ala Ser Tyr Phe Tyr Val Ala Ser Ser Leu Asp Pro Glu Leu 
        195                 200                 205             


Ala Ala Ser Phe Ser Pro Arg Ser Val Ser Ile Arg Arg Leu Lys Ser 
    210                 215                 220                 


Asp Thr Ser Gly Phe Gln Pro Gly Phe Pro Ser Leu Ser Val Leu Pro 
225                 230                 235                 240 


Lys Tyr Leu Ala Ser Tyr Leu Ile Lys Tyr Val Tyr Ser Phe His Ser 
                245                 250                 255     


Gly Asp Phe Val Tyr Phe Leu Thr Val Gln Pro Ile Ser Val Thr Ser 
            260                 265                 270         


Pro Pro Ser Ala Leu His Thr Arg Leu Val Arg Leu Asn Ala Val Glu 
        275                 280                 285             


Pro Glu Ile Gly Asp Tyr Arg Glu Leu Val Leu Asp Cys His Phe Ala 
    290                 295                 300                 


Pro Lys Arg Arg Arg Arg Gly Ala Pro Glu Gly Thr Gln Pro Tyr Pro 
305                 310                 315                 320 


Val Leu Gln Ala Ala His Ser Ala Pro Val Asp Ala Lys Leu Ala Val 
                325                 330                 335     


Glu Leu Ser Ile Ser Glu Gly Gln Glu Val Leu Phe Gly Val Phe Val 
            340                 345                 350         


Thr Val Lys Asp Gly Gly Ser Gly Met Gly Pro Asn Ser Val Val Cys 
        355                 360                 365             


Ala Phe Pro Ile Tyr His Leu Asn Ile Leu Ile Glu Glu Gly Val Glu 
    370                 375                 380                 


Tyr Cys Cys His Ser Ser Asn Ser Ser Ser Leu Leu Ser Arg Gly Leu 
385                 390                 395                 400 


Asp Phe Phe Gln Thr Pro Ser Phe Cys Pro Asn Pro Pro Gly Gly Glu 
                405                 410                 415     


Ala Ser Gly Pro Ser Ser Arg Cys His Tyr Phe Pro Leu Met Val His 
            420                 425                 430         


Ala Ser Phe Thr Arg Val Asp Leu Phe Asn Gly Leu Leu Gly Ser Val 
        435                 440                 445             


Lys Val Thr Ala Leu His Val Thr Arg Leu Gly Asn Val Thr Val Ala 
    450                 455                 460                 


His Met Gly Thr Val Asp Gly Arg Val Leu Gln Val Glu Ile Ala Arg 
465                 470                 475                 480 


Ser Leu Asn Tyr Leu Leu Tyr Val Ser Asn Phe Ser Leu Gly Ser Ser 
                485                 490                 495     


Gly Gln Pro Val His Arg Asp Val Ser Arg Leu Gly Asn Asp Leu Leu 
            500                 505                 510         


Phe Ala Ser Gly Asp Gln Val Phe Lys Val Pro Ile Gln Gly Pro Gly 
        515                 520                 525             


Cys Arg His Phe Leu Thr Cys Trp Arg Cys Leu Arg Ala Gln Arg Phe 
    530                 535                 540                 


Met Gly Cys Gly Trp Cys Gly Asp Arg Cys Asp Arg Gln Lys Glu Cys 
545                 550                 555                 560 


Pro Gly Ser Trp Gln Gln Asp His Cys Pro Pro Glu Ile Ser Glu Phe 
                565                 570                 575     


Tyr Pro His Ser Gly Pro Leu Arg Gly Thr Thr Arg Leu Thr Leu Cys 
            580                 585                 590         


Gly Ser Asn Phe Tyr Leu Arg Pro Asp Asp Val Val Pro Glu Gly Thr 
        595                 600                 605             


His Gln Ile Thr Val Gly Gln Ser Pro Cys Arg Leu Leu Pro Lys Asp 
    610                 615                 620                 


Ser Ser Ser Pro Arg Pro Gly Ser Leu Lys Glu Phe Ile Gln Glu Leu 
625                 630                 635                 640 


Glu Cys Glu Leu Glu Pro Leu Val Thr Gln Ala Val Gly Thr Thr Asn 
                645                 650                 655     


Ile Ser Leu Val Ile Thr Asn Met Pro Ala Gly Lys His Phe Arg Val 
            660                 665                 670         


Glu Gly Ile Ser Val Gln Glu Gly Phe Ser Phe Val Glu Pro Val Leu 
        675                 680                 685             


Thr Ser Ile Lys Pro Asp Phe Gly Pro Arg Ala Gly Gly Thr Tyr Leu 
    690                 695                 700                 


Thr Leu Glu Gly Gln Ser Leu Ser Val Gly Thr Ser Arg Ala Val Leu 
705                 710                 715                 720 


Val Asn Gly Thr Gln Cys Arg Leu Glu Gln Val Asn Glu Glu Gln Ile 
                725                 730                 735     


Leu Cys Val Thr Pro Pro Gly Ala Gly Thr Ala Arg Val Pro Leu His 
            740                 745                 750         


Leu Gln Ile Gly Gly Ala Glu Val Pro Gly Ser Trp Thr Phe His Tyr 
        755                 760                 765             


Lys Glu Asp Pro Ile Val Leu Asp Ile Ser Pro Lys Cys Gly Tyr Ser 
    770                 775                 780                 


Gly Ser His Ile Met Ile His Gly Gln His Leu Thr Ser Ala Trp His 
785                 790                 795                 800 


Phe Thr Leu Ser Phe His Asp Gly Gln Ser Thr Val Glu Ser Arg Cys 
                805                 810                 815     


Ala Gly Gln Phe Val Glu Gln Gln Gln Arg Arg Cys Arg Leu Pro Glu 
            820                 825                 830         


Tyr Val Val Arg Asn Pro Gln Gly Trp Ala Thr Gly Asn Leu Ser Val 
        835                 840                 845             


Trp Gly Asp Gly Ala Ala Gly Phe Thr Leu Pro Gly Phe Arg Phe Leu 
    850                 855                 860                 


Pro Pro Pro Ser Pro Leu Arg Ala Gly Leu Val Glu Leu Lys Pro Glu 
865                 870                 875                 880 


Glu His Ser Val Lys Val Glu Tyr Val Gly Leu Gly Ala Val Ala Asp 
                885                 890                 895     


Cys Val Thr Val Asn Met Thr Val Gly Gly Glu Val Cys Gln His Glu 
            900                 905                 910         


Leu Arg Gly Asp Val Val Ile Cys Pro Leu Pro Pro Ser Leu Gln Leu 
        915                 920                 925             


Gly Lys Asp Gly Val Pro Leu Gln Val Cys Val Asp Gly Gly Cys His 
    930                 935                 940                 


Ile Leu Ser Gln Val Val Arg Ser Ser Pro Gly Arg Ala Ser Gln Arg 
945                 950                 955                 960 


Ile Leu Leu Ile Ala Leu Leu Val Leu Ile Leu Leu Val Ala Val Leu 
                965                 970                 975     


Ala Val Ala Leu Ile Phe Asn Ser Arg Arg Arg Lys Lys Gln Leu Gly 
            980                 985                 990         


Ala His Ser Leu Ser Pro Thr Thr  Leu Ser Asp Ile Asn  Asp Thr Ala 
        995                 1000                 1005             


Ser Gly  Ala Pro Asn His Glu  Glu Ser Ser Glu Ser  Arg Asp Gly 
    1010                 1015                 1020             


Thr Ser  Val Pro Leu Leu Arg  Thr Glu Ser Ile Arg  Leu Gln Asp 
    1025                 1030                 1035             


Leu Asp  Arg Met Leu Leu Ala  Glu Val Lys Asp Val  Leu Ile Pro 
    1040                 1045                 1050             


His Glu  Gln Val Val Ile His  Thr Asp Gln Val Ile  Gly Lys Gly 
    1055                 1060                 1065             


His Phe  Gly Val Val Tyr His  Gly Glu Tyr Thr Asp  Gly Ala Gln 
    1070                 1075                 1080             


Asn Gln  Thr His Cys Ala Ile  Lys Ser Leu Ser Arg  Ile Thr Glu 
    1085                 1090                 1095             


Val Gln  Glu Val Glu Ala Phe  Leu Arg Glu Gly Leu  Leu Met Arg 
    1100                 1105                 1110             


Gly Leu  His His Pro Asn Ile  Leu Ala Leu Ile Gly  Ile Met Leu 
    1115                 1120                 1125             


Pro Pro  Glu Gly Leu Pro Arg  Val Leu Leu Pro Tyr  Met Arg His 
    1130                 1135                 1140             


Gly Asp  Leu Leu His Phe Ile  Arg Ser Pro Gln Arg  Asn Pro Thr 
    1145                 1150                 1155             


Val Lys  Asp Leu Val Ser Phe  Gly Leu Gln Val Ala  Cys Gly Met 
    1160                 1165                 1170             


Glu Tyr  Leu Ala Glu Gln Lys  Phe Val His Arg Asp  Leu Ala Ala 
    1175                 1180                 1185             


Arg Asn  Cys Met Leu Asp Glu  Ser Phe Thr Val Lys  Val Ala Asp 
    1190                 1195                 1200             


Phe Gly  Leu Ala Arg Gly Val  Leu Asp Lys Glu Tyr  Tyr Ser Val 
    1205                 1210                 1215             


Arg Gln  His Arg His Ala Arg  Leu Pro Val Lys Trp  Met Ala Leu 
    1220                 1225                 1230             


Glu Ser  Leu Gln Thr Tyr Arg  Phe Thr Thr Lys Ser  Asp Val Trp 
    1235                 1240                 1245             


Ser Phe  Gly Val Leu Leu Trp  Glu Leu Leu Thr Arg  Gly Ala Pro 
    1250                 1255                 1260             


Pro Tyr  Pro His Ile Asp Pro  Phe Asp Leu Ser His  Phe Leu Ala 
    1265                 1270                 1275             


Gln Gly  Arg Arg Leu Pro Gln  Pro Glu Tyr Cys Pro  Asp Ser Leu 
    1280                 1285                 1290             


Tyr His  Val Met Leu Arg Cys  Trp Glu Ala Asp Pro  Ala Ala Arg 
    1295                 1300                 1305             


Pro Thr  Phe Arg Ala Leu Val  Leu Glu Val Lys Gln  Val Val Ala 
    1310                 1315                 1320             


Ser Leu  Leu Gly Asp His Tyr  Val Gln Leu Thr Ala  Ala Tyr Val 
    1325                 1330                 1335             


Asn Val  Gly Pro Arg Ala Val  Asp Asp Gly Ser Val  Pro Pro Glu 
    1340                 1345                 1350             


Gln Val  Gln Pro Ser Pro Gln  His Cys Arg Ser Thr  Ser Lys Pro 
    1355                 1360                 1365             


Arg Pro  Leu Ser Glu Pro Pro  Leu Pro Thr 
    1370                 1375             


<210>  210
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  210

Gly Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly 
1               5                   10      


<210>  211
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  211

Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210>  212
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  212

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10          


<210>  213
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  213

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  214
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  214

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  215
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  215

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  216
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  216

Gly Gly Gly Gly Ser 
1               5   


<210>  217
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  217

Gly Gly Gly Gly Ser Gly Ser 
1               5           


<210>  218
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  218

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Ser 
    


<210>  219
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  219

Gly Gly Ser Leu Asp Pro Lys Gly Gly Gly Gly Ser 
1               5                   10          


<210>  220
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  220

Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
1               5                   10                  15      


Glu Leu Leu Gly 
            20  


<210>  221
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  221

Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
1               5                   10                  15      


Gly 
    


<210>  222
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  222

Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser 
1               5                   10          


<210>  223
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  223

Gly Ser Thr Ser Gly Ser Gly Lys Ser Ser Glu Gly Lys Gly 
1               5                   10                  


<210>  224
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  224

Gly Ser Thr Ser Gly Ser Gly Lys Ser Ser Glu Gly Ser Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  225
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  225

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  226
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  226

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Ser Glu Gly Ser Thr 
1               5                   10                  15      


<210>  227
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  227

Gly Ser Gly Gly Ser 
1               5   


<210>  228
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  228

Gly Gly Gly Ser 
1               


<210>  229
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  229

Gly Gly Ser Gly 
1               


<210>  230
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  230

Gly Gly Ser Gly Gly 
1               5   


<210>  231
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  231

Gly Ser Gly Ser Gly 
1               5   


<210>  232
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  232

Gly Ser Gly Gly Gly 
1               5   


<210>  233
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  233

Gly Gly Gly Ser Gly 
1               5   


<210>  234
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  234

Gly Ser Ser Ser Gly 
1               5   


<210>  235
<211>  430
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProC1023

<400>  235

Gln Ser Gly Gln Thr Asp Val Asp Tyr Tyr Arg Glu Trp Ser Trp Thr 
1               5                   10                  15      


Gln Val Ser Gly Ser Ser Gly Gly Ser Leu Ser Gly Arg Ser Asp Asn 
            20                  25                  30          


Ile Gly Ser Gly Gly Ser Cys Asp Leu Pro Gln Thr His Ser Leu Gly 
        35                  40                  45              


Ser Arg Arg Thr Leu Met Leu Leu Ala Gln Met Arg Lys Ile Ser Leu 
    50                  55                  60                  


Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu Glu 
65                  70                  75                  80  


Phe Gly Asn Gln Phe Gln Lys Ala Glu Thr Ile Pro Val Leu His Glu 
                85                  90                  95      


Met Ile Gln Gln Ile Phe Asn Leu Phe Thr Thr Lys Asp Ser Ser Ala 
            100                 105                 110         


Ala Trp Asp Glu Asp Leu Leu Asp Lys Phe Cys Thr Glu Leu Tyr Gln 
        115                 120                 125             


Gln Leu Asn Asp Leu Glu Ala Cys Val Met Gln Glu Glu Arg Val Gly 
    130                 135                 140                 


Glu Thr Pro Leu Met Asn Val Asp Ser Ile Leu Ala Val Lys Lys Tyr 
145                 150                 155                 160 


Phe Arg Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser Pro Cys 
                165                 170                 175     


Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser Leu Ser 
            180                 185                 190         


Thr Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu Leu Ser Gly Arg Ser 
        195                 200                 205             


Asp Asn Ile Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
    210                 215                 220                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
225                 230                 235                 240 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                245                 250                 255     


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            260                 265                 270         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        275                 280                 285             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    290                 295                 300                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
305                 310                 315                 320 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                325                 330                 335     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            340                 345                 350         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        355                 360                 365             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    370                 375                 380                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
385                 390                 395                 400 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                405                 410                 415     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            420                 425                 430 


<210>  236
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProC1549

<400>  236

Gln Ser Gly Gln Thr Asp Val Asp Tyr Tyr Arg Glu Trp Ser Trp Thr 
1               5                   10                  15      


Gln Val Ser Gly Ser Ser Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
            20                  25                  30          


Ser Gly Ser Gly Gly Ser Cys Asp Leu Pro Gln Thr His Ser Leu Gly 
        35                  40                  45              


Ser Arg Arg Thr Leu Met Leu Leu Ala Gln Met Arg Lys Ile Ser Leu 
    50                  55                  60                  


Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu Glu 
65                  70                  75                  80  


Phe Gly Asn Gln Phe Gln Lys Ala Glu Thr Ile Pro Val Leu His Glu 
                85                  90                  95      


Met Ile Gln Gln Ile Phe Asn Leu Phe Thr Thr Lys Asp Ser Ser Ala 
            100                 105                 110         


Ala Trp Asp Glu Asp Leu Leu Asp Lys Phe Cys Thr Glu Leu Tyr Gln 
        115                 120                 125             


Gln Leu Asn Asp Leu Glu Ala Cys Val Met Gln Glu Glu Arg Val Gly 
    130                 135                 140                 


Glu Thr Pro Leu Met Asn Val Asp Ser Ile Leu Ala Val Lys Lys Tyr 
145                 150                 155                 160 


Phe Arg Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser Pro Cys 
                165                 170                 175     


Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser Leu Ser 
            180                 185                 190         


Thr Asn Leu Gln Glu Arg Arg Arg Lys Glu Gly Gly Ser Gly Gly Gly 
        195                 200                 205             


Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
    210                 215                 220                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
225                 230                 235                 240 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
                245                 250                 255     


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            260                 265                 270         


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
        275                 280                 285             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    290                 295                 300                 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
305                 310                 315                 320 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                325                 330                 335     


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
            340                 345                 350         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        355                 360                 365             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    370                 375                 380                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
385                 390                 395                 400 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                405                 410                 415     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            420                 425                 


<210>  237
<211>  391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProC659 (non-cleavable steric masked IFN-a2b)

<400>  237

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu Gly Gly Gly Ser Gly Gly Ser Cys Pro Pro Cys 
                165                 170                 175     


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            180                 185                 190         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        195                 200                 205             


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
    210                 215                 220                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
225                 230                 235                 240 


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                245                 250                 255     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            260                 265                 270         


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        275                 280                 285             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
    290                 295                 300                 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
305                 310                 315                 320 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                325                 330                 335     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            340                 345                 350         


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        355                 360                 365             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    370                 375                 380                 


Gln Lys Ser Leu Ser Leu Ser 
385                 390     


<210>  238
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProC1239 Arm 1

<400>  238

Gln Ser Gly Gln Thr Asp Val Asp Tyr Tyr Arg Glu Trp Ser Trp Thr 
1               5                   10                  15      


Gln Val Ser Gly Ser Ser Gly Gly Ser Leu Ser Gly Arg Ser Asp Asn 
            20                  25                  30          


Ile Gly Ser Gly Gly Ser Cys Asp Leu Pro Gln Thr His Ser Leu Gly 
        35                  40                  45              


Ser Arg Arg Thr Leu Met Leu Leu Ala Gln Met Arg Arg Ile Ser Leu 
    50                  55                  60                  


Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu Glu 
65                  70                  75                  80  


Phe Gly Asn Gln Phe Gln Lys Ala Glu Thr Ile Pro Val Leu His Glu 
                85                  90                  95      


Met Ile Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala 
            100                 105                 110         


Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln 
        115                 120                 125             


Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Gly Val Gly Val Thr 
    130                 135                 140                 


Glu Thr Pro Leu Met Lys Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr 
145                 150                 155                 160 


Phe Gln Arg Ile Thr Leu Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys 
                165                 170                 175     


Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser Leu Ser 
            180                 185                 190         


Thr Asn Leu Gln Glu Ser Leu Arg Ser Lys Glu Leu Ser Gly Arg Ser 
        195                 200                 205             


Asp Asn Ile Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro 
    210                 215                 220                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
225                 230                 235                 240 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                245                 250                 255     


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            260                 265                 270         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        275                 280                 285             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    290                 295                 300                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
305                 310                 315                 320 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                325                 330                 335     


Leu Pro Pro Cys Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp 
            340                 345                 350         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        355                 360                 365             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    370                 375                 380                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
385                 390                 395                 400 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                405                 410                 415     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            420                 425                 430         


Lys 
    


<210>  239
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProC1239 Arm 2

<400>  239

Ser Asp Asn Ile Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly 
1               5                   10                  15      


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            20                  25                  30          


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
        35                  40                  45              


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    50                  55                  60                  


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
65                  70                  75                  80  


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                85                  90                  95      


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
            100                 105                 110         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys 
        115                 120                 125             


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    130                 135                 140                 


Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
145                 150                 155                 160 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                165                 170                 175     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Arg Leu Thr Val Asp 
            180                 185                 190         


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
        195                 200                 205             


Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Leu 
    210                 215                 220                 


Gly 
225 


<210>  240
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProC1301

<400>  240

Gln Ser Gly Gln Thr Asp Val Asp Tyr Tyr Arg Glu Trp Ser Trp Thr 
1               5                   10                  15      


Gln Val Ser Gly Ser Ser Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
            20                  25                  30          


Ser Gly Ser Gly Gly Ser Cys Asp Leu Pro Gln Thr His Ser Leu Gly 
        35                  40                  45              


Ser Arg Arg Thr Leu Met Leu Leu Ala Gln Met Arg Arg Ile Ser Leu 
    50                  55                  60                  


Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu Glu 
65                  70                  75                  80  


Phe Gly Asn Gln Phe Gln Lys Ala Glu Thr Ile Pro Val Leu His Glu 
                85                  90                  95      


Met Ile Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala 
            100                 105                 110         


Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln 
        115                 120                 125             


Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Gly Val Gly Val Thr 
    130                 135                 140                 


Glu Thr Pro Leu Met Lys Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr 
145                 150                 155                 160 


Phe Gln Arg Ile Thr Leu Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys 
                165                 170                 175     


Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser Leu Ser 
            180                 185                 190         


Thr Asn Leu Gln Glu Ser Arg Ser Lys Glu Gly Gly Ser Gly Gly Gly 
        195                 200                 205             


Gly Ser Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
    210                 215                 220                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
225                 230                 235                 240 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
                245                 250                 255     


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            260                 265                 270         


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
        275                 280                 285             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    290                 295                 300                 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
305                 310                 315                 320 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                325                 330                 335     


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
            340                 345                 350         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        355                 360                 365             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    370                 375                 380                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
385                 390                 395                 400 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                405                 410                 415     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            420                 425                 


<210>  241
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  241

Gly Leu Ser Gly Arg Ser Asp Asn His Gly 
1               5                   10  


<210>  242
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal Sequence

<400>  242

Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Ala 
    


<210>  243
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal sequence

<400>  243

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly 
            20              


<210>  244
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal sequence

<400>  244

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  245
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  245

Gly Pro Gln Gly Thr Ala Gly Gln 
1               5               


<210>  246
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  246

Gln Gly Gln Ser Gly Ser 
1               5       


<210>  247
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  247

Gly Gln Ser Gly Ser 
1               5   


<210>  248
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  248

Gln Ser Gly Ser 
1               


<210>  249
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  249

Gln Gly Gln Ser Gly Gln Gly 
1               5           


<210>  250
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  250

Tyr Gly Ala Gly Leu Gly Trp 
1               5           


<210>  251
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  251

Gly Gln Ser Gly Gln Gly 
1               5       


<210>  252
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  252

Gln Ser Gly Gln Gly 
1               5   


<210>  253
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  253

Ser Gly Gln Gly 
1               


<210>  254
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  254

Gln Gly Gln Ser Gly Gln 
1               5       


<210>  255
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  255

Gly Gln Ser Gly Gln 
1               5   


<210>  256
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  256

Gln Ser Gly Gln 
1               


<210>  257
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  257

Gln Gly Gln Ser Gly 
1               5   


<210>  258
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  258

Gln Gly Gln Ser 
1               


<210>  259
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProC1640

<400>  259

Asp Asn Ile Gly Ser Gly Gly Ser Cys Asp Leu Pro Gln Thr His Ser 
1               5                   10                  15      


Leu Gly Ser Arg Arg Thr Leu Met Leu Leu Ala Gln Met Arg Arg Ile 
            20                  25                  30          


Ser Leu Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln 
        35                  40                  45              


Glu Glu Phe Gly Asn Gln Phe Gln Lys Ala Glu Thr Ile Pro Val Leu 
    50                  55                  60                  


His Glu Met Ile Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp Ser 
65                  70                  75                  80  


Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu 
                85                  90                  95      


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Gly Val Gly 
            100                 105                 110         


Val Thr Glu Thr Pro Leu Met Lys Glu Asp Ser Ile Leu Ala Val Arg 
        115                 120                 125             


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Lys Glu Lys Lys Tyr Ser 
    130                 135                 140                 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
145                 150                 155                 160 


Leu Ser Thr Asn Leu Gln Glu Ser Leu Arg Ser Lys Glu Leu Ser Gly 
                165                 170                 175     


Arg Ser 
        


<210>  260
<211>  639
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProC1822

<400>  260

Lys Asn Leu Lys Ser Pro Gln Lys Val Glu Val Asp Ile Ile Asp Asp 
1               5                   10                  15      


Asn Phe Ile Leu Arg Trp Asn Arg Ser Asp Glu Ser Val Gly Asn Val 
            20                  25                  30          


Thr Phe Ser Phe Asp Tyr Gln Lys Thr Gly Met Asp Asn Trp Ile Lys 
        35                  40                  45              


Leu Ser Gly Cys Gln Asn Ile Thr Ser Thr Lys Cys Asn Phe Ser Ser 
    50                  55                  60                  


Leu Lys Leu Asn Val Tyr Glu Glu Ile Lys Leu Arg Ile Arg Ala Glu 
65                  70                  75                  80  


Lys Glu Asn Thr Ser Ser Trp Tyr Glu Val Asp Ser Phe Thr Pro Phe 
                85                  90                  95      


Arg Lys Ala Gln Ile Gly Pro Pro Glu Val His Leu Glu Ala Glu Asp 
            100                 105                 110         


Lys Ala Ile Val Ile His Ile Ser Pro Gly Thr Lys Asp Ser Val Met 
        115                 120                 125             


Trp Ala Leu Asp Gly Leu Ser Phe Thr Tyr Ser Leu Val Ile Trp Lys 
    130                 135                 140                 


Asn Ser Ser Gly Val Glu Glu Arg Ile Glu Asn Ile Tyr Ser Arg His 
145                 150                 155                 160 


Lys Ile Tyr Lys Leu Ser Pro Glu Thr Thr Tyr Cys Leu Lys Val Lys 
                165                 170                 175     


Ala Ala Leu Leu Thr Ser Trp Lys Ile Gly Val Tyr Ser Pro Val His 
            180                 185                 190         


Cys Ile Lys Thr Thr Val Glu Asn Glu Leu Pro Pro Pro Glu Asn Ile 
        195                 200                 205             


Glu Val Ser Val Gln Asn Gln Asn Tyr Val Leu Lys Trp Asp Tyr Thr 
    210                 215                 220                 


Tyr Ala Asn Met Thr Phe Gln Val Gln Trp Leu His Ala Phe Leu Lys 
225                 230                 235                 240 


Arg Asn Pro Gly Asn His Leu Tyr Lys Trp Lys Gln Ile Pro Asp Cys 
                245                 250                 255     


Glu Asn Val Lys Thr Thr Gln Cys Val Phe Pro Gln Asn Val Phe Gln 
            260                 265                 270         


Lys Gly Ile Tyr Leu Leu Arg Val Gln Ala Ser Asp Gly Asn Asn Thr 
        275                 280                 285             


Ser Phe Trp Ser Glu Glu Ile Lys Phe Asp Thr Glu Ile Gln Ala Phe 
    290                 295                 300                 


Leu Leu Pro Pro Val Phe Asn Ile Arg Ser Leu Ser Asp Ser Phe His 
305                 310                 315                 320 


Ile Tyr Ile Gly Ala Pro Lys Gln Ser Gly Asn Thr Pro Val Ile Gln 
                325                 330                 335     


Asp Tyr Pro Leu Ile Tyr Glu Ile Ile Phe Trp Glu Asn Thr Ser Asn 
            340                 345                 350         


Ala Glu Arg Lys Ile Ile Glu Lys Lys Thr Asp Val Thr Val Pro Asn 
        355                 360                 365             


Leu Lys Pro Leu Thr Val Tyr Cys Val Lys Ala Arg Ala His Thr Met 
    370                 375                 380                 


Asp Glu Lys Leu Asn Lys Ser Ser Val Phe Ser Asp Ala Val Cys Glu 
385                 390                 395                 400 


Lys Thr Lys Pro Gly Asn Thr Ser Lys Pro Lys Ser Cys Asp Lys Thr 
                405                 410                 415     


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
            420                 425                 430         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        435                 440                 445             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    450                 455                 460                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
465                 470                 475                 480 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                485                 490                 495     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            500                 505                 510         


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
        515                 520                 525             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    530                 535                 540                 


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
545                 550                 555                 560 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                565                 570                 575     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            580                 585                 590         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        595                 600                 605             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    610                 615                 620                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
625                 630                 635                 


<210>  261
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProC1823

<400>  261

Ile Ser Tyr Asp Ser Pro Asp Tyr Thr Asp Glu Ser Cys Thr Phe Lys 
1               5                   10                  15      


Ile Ser Leu Arg Asn Phe Arg Ser Ile Leu Ser Trp Glu Leu Lys Asn 
            20                  25                  30          


His Ser Ile Val Pro Thr His Tyr Thr Leu Leu Tyr Thr Ile Met Ser 
        35                  40                  45              


Lys Pro Glu Asp Leu Lys Val Val Lys Asn Cys Ala Asn Thr Thr Arg 
    50                  55                  60                  


Ser Phe Cys Asp Leu Thr Asp Glu Trp Arg Ser Thr His Glu Ala Tyr 
65                  70                  75                  80  


Val Thr Val Leu Glu Gly Phe Ser Gly Asn Thr Thr Leu Phe Ser Cys 
                85                  90                  95      


Ser His Asn Phe Trp Leu Ala Ile Asp Met Ser Phe Glu Pro Pro Glu 
            100                 105                 110         


Phe Glu Ile Val Gly Phe Thr Asn His Ile Asn Val Met Val Lys Phe 
        115                 120                 125             


Pro Ser Ile Val Glu Glu Glu Leu Gln Phe Asp Leu Ser Leu Val Ile 
    130                 135                 140                 


Glu Glu Gln Ser Glu Gly Ile Val Lys Lys His Lys Pro Glu Ile Lys 
145                 150                 155                 160 


Gly Asn Met Ser Gly Asn Phe Thr Tyr Ile Ile Asp Lys Leu Ile Pro 
                165                 170                 175     


Asn Thr Asn Tyr Cys Val Ser Val Tyr Leu Glu His Ser Asp Glu Gln 
            180                 185                 190         


Ala Val Ile Lys Ser Pro Leu Lys Cys Thr Leu Leu Pro Pro Gly Gln 
        195                 200                 205             


Glu Ser Glu Ser Ala Glu Ser Ala Lys Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445         


<210>  262
<211>  640
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProC1824

<400>  262

Lys Asn Leu Lys Ser Pro Gln Lys Val Glu Val Asp Val Ile Asp Asp 
1               5                   10                  15      


Asn Phe Ile Leu Arg Trp Asn Arg Ser Glu Glu Ser Val Gly Asn Val 
            20                  25                  30          


Thr Phe Ser Phe Asp Tyr Gln Lys Pro Glu Met Asp Asn Trp Ile Lys 
        35                  40                  45              


Leu Pro Gly Cys Gln Asn Met Thr Ser Thr Lys Cys Asn Phe Ser Ser 
    50                  55                  60                  


Leu Lys Leu Asn Ile Tyr Asp Glu Ile Lys Leu Arg Ile Arg Ala Glu 
65                  70                  75                  80  


Lys Glu Asn Thr Ser Ser Trp Cys Glu Val Asp Ser Phe Thr Pro Phe 
                85                  90                  95      


Arg Lys Ala Gln Ile Gly Pro Pro Glu Val His Leu Glu Ala Glu Asp 
            100                 105                 110         


Lys Ala Ile Val Ile Tyr Ile Ser Pro Pro Gly Thr Glu Asp Ser Val 
        115                 120                 125             


Met Trp Ala Leu Asp Arg Ser Ser Phe Thr Tyr Ser Leu Val Ile Trp 
    130                 135                 140                 


Lys Asn Ser Ser Ser Val Glu Glu Arg Ile Glu Asn Ile Tyr Ser Arg 
145                 150                 155                 160 


His Lys Ile Ser Lys Leu Ser Pro Glu Thr Thr Tyr Cys Leu Lys Val 
                165                 170                 175     


Lys Ala Ala Leu Leu Thr Ser Arg Lys Ile Gly Val Tyr Gly Pro Val 
            180                 185                 190         


His Cys Ile Lys Thr Thr Val Glu Asn Glu Leu Pro Pro Pro Glu Asn 
        195                 200                 205             


Ile Glu Val Ile Val Gln Asn Gln Asn Tyr Val Leu Lys Trp Asp Tyr 
    210                 215                 220                 


Thr Tyr Ala Asn Met Thr Phe Gln Val Gln Trp Leu His Ala Phe Leu 
225                 230                 235                 240 


Lys Arg Lys Pro Gly Asn His Leu Tyr Lys Trp Lys Gln Ile Pro Asp 
                245                 250                 255     


Cys Glu Asn Val Thr Thr Thr Gln Cys Val Phe Pro Pro Asn Thr Phe 
            260                 265                 270         


Gln Lys Gly Ile Tyr Leu Leu Arg Val Gln Ala Ser Asp Gly Asn Asn 
        275                 280                 285             


Thr Ser Phe Trp Ser Glu Glu Ile Lys Phe Asp Thr Glu Ile Gln Ala 
    290                 295                 300                 


Ser Leu Leu Pro Pro Val Phe Asn Ile Arg Ser Leu Ser Asp Ser Leu 
305                 310                 315                 320 


His Ile Ser Ile Gly Ala Pro Lys Trp Ser Glu Asn Lys Pro Val Ile 
                325                 330                 335     


Gln Asp Tyr Pro Leu Ile Tyr Glu Ile Leu Phe Trp Glu Asn Thr Ser 
            340                 345                 350         


Lys Ala Glu Arg Lys Ile Ile Lys Lys Lys Thr Asp Val Thr Ile Pro 
        355                 360                 365             


Asn Leu Lys Pro Leu Thr Val Tyr Cys Val Lys Ala Arg Ala His Ser 
    370                 375                 380                 


Met Asp Glu Lys Leu Asn Lys Ser Ser Val Phe Ser Asp Val Val Cys 
385                 390                 395                 400 


Glu Glu Thr Lys Ser Gly Asn Thr Ser Lys Pro Lys Ser Cys Asp Lys 
                405                 410                 415     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            420                 425                 430         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        435                 440                 445             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    450                 455                 460                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
465                 470                 475                 480 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                485                 490                 495     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            500                 505                 510         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        515                 520                 525             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    530                 535                 540                 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
545                 550                 555                 560 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                565                 570                 575     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            580                 585                 590         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        595                 600                 605             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    610                 615                 620                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
625                 630                 635                 640 


<210>  263
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProC1825

<400>  263

Ile Ser His Asp Leu Pro Asp Tyr Thr Ser Glu Ser Cys Thr Phe Lys 
1               5                   10                  15      


Ile Ser Leu Arg Asn Phe Arg Ser Ile Leu Ser Trp Glu Leu Lys Asn 
            20                  25                  30          


His Ser Ile Val Ala Thr His Tyr Lys Leu Leu Tyr Thr Ile Met Ser 
        35                  40                  45              


Lys Pro Glu Asp Leu Lys Ile Val Lys Asn Cys Ala Asn Thr Thr Arg 
    50                  55                  60                  


Ser Phe Cys Asp Leu Thr Asp Glu Trp Arg Ser Thr His Glu Ala Tyr 
65                  70                  75                  80  


Val Thr Ser Leu Glu Gly Phe Ser Gly Asn Thr Thr Leu Phe Asn Cys 
                85                  90                  95      


Ser His Asn Phe Trp Leu Asp Ile Asp Met Ser Phe Glu Pro Pro Glu 
            100                 105                 110         


Phe Glu Ile Val Gly Phe Thr Asn His Ile Asn Val Ile Val Lys Phe 
        115                 120                 125             


Pro Ser Ile Val Glu Glu Glu Leu Gln Phe Asp Leu Ser Leu Val Ile 
    130                 135                 140                 


Glu Glu Gln Ser Glu Gly Ile Val Lys Lys His Lys Pro Thr Ile Lys 
145                 150                 155                 160 


Gly Asn Met Ser Gly Asn Phe Thr Tyr Ile Ile Asp Lys Leu Ile Pro 
                165                 170                 175     


Asn Thr Asn Tyr Cys Val Ser Val Tyr Phe Asp His Asn Asp Glu Gln 
            180                 185                 190         


Ala Val Ile Lys Ser Pro Leu Lys Cys Thr Leu Leu Gln Pro Gly Gln 
        195                 200                 205             


Glu Ser Glu Ser Ala Glu Ser Ala Lys Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445         


<210>  264
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  264

Ala Gln Asn Leu Leu Gly Met Tyr 
1               5               


<210>  265
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  265

Leu Ser Gly Arg Ser Asp Asn His Gly Gly Ala Val Gly Leu Leu Ala 
1               5                   10                  15      


Pro Pro 
        


<210>  266
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  266

Val His Met Pro Leu Gly Phe Leu Gly Pro Gly Gly Leu Ser Gly Arg 
1               5                   10                  15      


Ser Asp Asn His 
            20  


<210>  267
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  267

Leu Ser Gly Arg Ser Asp Asn His Gly Gly Val His Met Pro Leu Gly 
1               5                   10                  15      


Phe Leu Gly Pro 
            20  


<210>  268
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  268

Leu Ser Gly Arg Ser Asp Asn His Gly Gly Ser Gly Gly Ser Ile Ser 
1               5                   10                  15      


Ser Gly Leu Leu Ser Ser 
            20          


<210>  269
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  269

Ile Ser Ser Gly Leu Leu Ser Ser Gly Gly Ser Gly Gly Ser Leu Ser 
1               5                   10                  15      


Gly Arg Ser Gly Asn His 
            20          


<210>  270
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  270

Leu Ser Gly Arg Ser Asp Asn His Gly Gly Ser Gly Gly Ser Gln Asn 
1               5                   10                  15      


Gln Ala Leu Arg Met Ala 
            20          


<210>  271
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  271

Gln Asn Gln Ala Leu Arg Met Ala Gly Gly Ser Gly Gly Ser Leu Ser 
1               5                   10                  15      


Gly Arg Ser Asp Asn His 
            20          


<210>  272
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  272

Leu Ser Gly Arg Ser Gly Asn His Gly Gly Ser Gly Gly Ser Gln Asn 
1               5                   10                  15      


Gln Ala Leu Arg Met Ala 
            20          


<210>  273
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  273

Gln Asn Gln Ala Leu Arg Met Ala Gly Gly Ser Gly Gly Ser Leu Ser 
1               5                   10                  15      


Gly Arg Ser Gly Asn His 
            20          


<210>  274
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  274

Ile Ser Ser Gly Leu Leu Ser Gly Arg Ser Gly Asn His 
1               5                   10              


<210>  275
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  275

Ala Val Gly Leu Leu Ala Pro Pro Gly Gly Thr Ser Thr Ser Gly Arg 
1               5                   10                  15      


Ser Ala Asn Pro Arg Gly 
            20          


<210>  276
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  276

Thr Ser Thr Ser Gly Arg Ser Ala Asn Pro Arg Gly Gly Gly Ala Val 
1               5                   10                  15      


Gly Leu Leu Ala Pro Pro 
            20          


<210>  277
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  277

Val His Met Pro Leu Gly Phe Leu Gly Pro Gly Gly Thr Ser Thr Ser 
1               5                   10                  15      


Gly Arg Ser Ala Asn Pro Arg Gly 
            20                  


<210>  278
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  278

Thr Ser Thr Ser Gly Arg Ser Ala Asn Pro Arg Gly Gly Gly Val His 
1               5                   10                  15      


Met Pro Leu Gly Phe Leu Gly Pro 
            20                  


<210>  279
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  279

Leu Ser Gly Arg Ser Gly Asn His Gly Gly Ser Gly Gly Ser Ile Ser 
1               5                   10                  15      


Ser Gly Leu Leu Ser Ser 
            20          


<210>  280
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable sequence

<400>  280

Pro Arg Phe Lys Ile Ile Gly Gly 
1               5               


<210>  281
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable sequence

<400>  281

Pro Arg Phe Arg Ile Ile Gly Gly 
1               5               


<210>  282
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable sequence

<400>  282

Ser Ser Arg His Arg Arg Ala Leu Asp 
1               5                   


<210>  283
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable sequence

<400>  283

Arg Lys Ser Ser Ile Ile Ile Arg Met Arg Asp Val Val Leu 
1               5                   10                  


<210>  284
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable sequence

<400>  284

Ser Ser Ser Phe Asp Lys Gly Lys Tyr Lys Lys Gly Asp Asp Ala 
1               5                   10                  15  


<210>  285
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable sequence

<400>  285

Ser Ser Ser Phe Asp Lys Gly Lys Tyr Lys Arg Gly Asp Asp Ala 
1               5                   10                  15  


<210>  286
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable sequence

<400>  286

Ile Glu Gly Arg 
1               


<210>  287
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable sequence

<400>  287

Ile Asp Gly Arg 
1               


<210>  288
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable sequence

<400>  288

Gly Gly Ser Ile Asp Gly Arg 
1               5           


<210>  289
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable sequence

<400>  289

Pro Leu Gly Leu Trp Ala 
1               5       


<210>  290
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable sequence

<400>  290

Gly Pro Gln Gly Ile Ala Gly Gln 
1               5               


<210>  291
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable sequence

<400>  291

Gly Pro Gln Gly Leu Leu Gly Ala 
1               5               


<210>  292
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable sequence

<400>  292

Gly Ile Ala Gly Gln 
1               5   


<210>  293
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable

<400>  293

Gly Pro Leu Gly Ile Ala Gly Ile 
1               5               


<210>  294
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable sequence

<400>  294

Gly Pro Glu Gly Leu Arg Val Gly 
1               5               


<210>  295
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable sequence

<400>  295

Tyr Gly Ala Gly Leu Gly Val Val 
1               5               


<210>  296
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable sequence

<400>  296

Ala Gly Leu Gly Val Val Glu Arg 
1               5               


<210>  297
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable sequence

<400>  297

Ala Gly Leu Gly Ile Ser Ser Thr 
1               5               


<210>  298
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  298

<400>  298

Glu Pro Gln Ala Leu Ala Met Ser 
1               5               


<210>  299
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable sequence

<400>  299

Gln Ala Leu Ala Met Ser Ala Ile 
1               5               


<210>  300
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable sequence

<400>  300

Ala Ala Tyr His Leu Val Ser Gln 
1               5               


<210>  301
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable sequence

<400>  301

Met Asp Ala Phe Leu Glu Ser Ser 
1               5               


<210>  302
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable sequence

<400>  302

Glu Ser Leu Pro Val Val Ala Val 
1               5               


<210>  303
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable sequence

<400>  303

Ser Ala Pro Ala Val Glu Ser Glu 
1               5               


<210>  304
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable sequence

<400>  304

Asp Val Ala Gln Phe Val Leu Thr 
1               5               


<210>  305
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable sequence

<400>  305

Val Ala Gln Phe Val Leu Thr 
1               5           


<210>  306
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable sequence

<400>  306

Val Ala Gln Phe Val Leu Thr Glu 
1               5               


<210>  307
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable sequence

<400>  307

Ala Gln Phe Val Leu Thr Glu Gly 
1               5               


<210>  308
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable sequence

<400>  308

Pro Val Gln Pro Ile Gly Pro Gln 
1               5               


<210>  309
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFN-?2b-1204dL-hIgG4, with signal sequence

<400>  309

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg 
            20                  25                  30          


Arg Thr Leu Met Leu Leu Ala Gln Met Arg Arg Ile Ser Leu Phe Ser 
        35                  40                  45              


Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly 
    50                  55                  60                  


Asn Gln Phe Gln Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile 
65                  70                  75                  80  


Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp 
                85                  90                  95      


Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu 
            100                 105                 110         


Asn Asp Leu Glu Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr 
        115                 120                 125             


Pro Leu Met Lys Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln 
    130                 135                 140                 


Arg Ile Thr Leu Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp 
145                 150                 155                 160 


Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn 
                165                 170                 175     


Leu Gln Glu Ser Leu Arg Ser Lys Glu Ser Gly Arg Ser Asp Asn Ile 
            180                 185                 190         


Gly Gly Gly Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
        195                 200                 205             


Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    210                 215                 220                 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
225                 230                 235                 240 


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
                245                 250                 255     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            260                 265                 270         


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        275                 280                 285             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    290                 295                 300                 


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
305                 310                 315                 320 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
                325                 330                 335     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            340                 345                 350         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        355                 360                 365             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    370                 375                 380                 


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
385                 390                 395                 400 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                405                 410                 415     


Lys Ser Leu Ser Leu Ser 
            420         


<210>  310
<211>  1269
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IFN-?-1204dL-hIgG4

<400>  310
atggaaaccg acacactgct gctgtgggtg ctgcttttgt gggtgccagg atccacaggc       60

tgtgatctgc ctcaaacgca ttcattgggg tccaggcgca cgcttatgtt gcttgcacag      120

atgaggagaa tatcactttt ctcttgcttg aaggaccgcc acgattttgg ctttccgcag      180

gaagagttcg gtaaccagtt ccaaaaggca gagacaatcc ccgttttgca tgagatgatc      240

caacagatct ttaacctgtt ttcaaccaag gatagcagcg cagcgtggga tgagacactg      300

cttgacaagt tttacaccga gctctatcag caacttaatg atctcgaagc ctgcgtaatt      360

caaggagtag gcgttacaga gacacctttg atgaaggagg attccatcct tgcagtaaga      420

aaatacttcc agaggatcac cctctacctc aaagaaaaga aatactcccc atgcgcgtgg      480

gaagtagtgc gagctgaaat aatgcggagc ttttctttgt caactaatct ccaagaatct      540

ctgagaagca aggagtcagg taggtctgat aatatcgggg gaggttctga atctaagtac      600

ggccctcctt gtcctccatg tcctgctcca gagtttctcg gaggcccctc cgtgttcctg      660

tttcctccaa agcctaagga caccctgatg atcagcagaa cccctgaagt gacctgcgtg      720

gtggtcgacg tttcacaaga ggaccccgag gtgcagttca attggtacgt ggacggcgtg      780

gaagtgcaca acgccaagac caagcctaga gaggaacagt tcaacagcac ctacagagtg      840

gtgtccgtgc tgaccgtgct gcaccaggat tggctgaacg gcaaagagta caagtgcaag      900

gtgtccaaca agggcctgcc tagcagcatc gagaaaacca tcagcaaggc caagggccag      960

ccaagggaac cccaggttta cacactgcca cctagccaag aggaaatgac caagaaccag     1020

gtgtccctga cctgcctggt caagggcttt tacccctccg atatcgccgt ggaatgggag     1080

agcaatggcc agcctgagaa caactacaag accacacctc ctgtgctgga cagcgacggc     1140

tcattcttcc tgtacagcag actgaccgtg gacaagagca gatggcagca gggcaacgtg     1200

ttcagctgca gcgtgatgca cgaggccctg cacaaccact acacccagaa gtctctgagc     1260

ctgagctga                                                             1269


<210>  311
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFN-?2b-1490DNI-hIgG4, with signal sequence

<400>  311

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg 
            20                  25                  30          


Arg Thr Leu Met Leu Leu Ala Gln Met Arg Arg Ile Ser Leu Phe Ser 
        35                  40                  45              


Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly 
    50                  55                  60                  


Asn Gln Phe Gln Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile 
65                  70                  75                  80  


Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp 
                85                  90                  95      


Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu 
            100                 105                 110         


Asn Asp Leu Glu Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr 
        115                 120                 125             


Pro Leu Met Lys Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln 
    130                 135                 140                 


Arg Ile Thr Leu Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp 
145                 150                 155                 160 


Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn 
                165                 170                 175     


Leu Gln Glu Ser Leu Arg Ser Lys Glu Ile Ser Ser Gly Leu Leu Ser 
            180                 185                 190         


Gly Arg Ser Asp Asn Ile Gly Gly Gly Ser Glu Ser Lys Tyr Gly Pro 
        195                 200                 205             


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
    210                 215                 220                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
225                 230                 235                 240 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
                245                 250                 255     


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            260                 265                 270         


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
        275                 280                 285             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    290                 295                 300                 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
305                 310                 315                 320 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                325                 330                 335     


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            340                 345                 350         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        355                 360                 365             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    370                 375                 380                 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
385                 390                 395                 400 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                405                 410                 415     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            420                 425             


<210>  312
<211>  1287
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IFN-?2b-1490DNI-hIgG4

<400>  312
atggaaaccg acacactgct gctgtgggtg ctgcttttgt gggtgccagg atccacaggc       60

tgtgatctgc ctcaaacgca ttcattgggg tccaggcgca cgcttatgtt gcttgcacag      120

atgaggagaa tatcactttt ctcttgcttg aaggaccgcc acgattttgg ctttccgcag      180

gaagagttcg gtaaccagtt ccaaaaggca gagacaatcc ccgttttgca tgagatgatc      240

caacagatct ttaacctgtt ttcaaccaag gatagcagcg cagcgtggga tgagacactg      300

cttgacaagt tttacaccga gctctatcag caacttaatg atctcgaagc ctgcgtaatt      360

caaggagtag gcgttacaga gacacctttg atgaaggagg attccatcct tgcagtaaga      420

aaatacttcc agaggatcac cctctacctc aaagaaaaga aatactcccc atgcgcgtgg      480

gaagtagtgc gagctgaaat aatgcggagc ttttctttgt caactaatct ccaagaatct      540

ctgagaagca aggagattag ttctggcctg ctgtcaggta ggtctgataa tatcggggga      600

ggttctgaat ctaagtacgg ccctccttgt cctccatgtc ctgctccaga gtttctcgga      660

ggcccctccg tgttcctgtt tcctccaaag cctaaggaca ccctgatgat cagcagaacc      720

cctgaagtga cctgcgtggt ggtcgacgtt tcacaagagg accccgaggt gcagttcaat      780

tggtacgtgg acggcgtgga agtgcacaac gccaagacca agcctagaga ggaacagttc      840

aacagcacct acagagtggt gtccgtgctg accgtgctgc accaggattg gctgaacggc      900

aaagagtaca agtgcaaggt gtccaacaag ggcctgccta gcagcatcga gaaaaccatc      960

agcaaggcca agggccagcc aagggaaccc caggtttaca cactgccacc tagccaagag     1020

gaaatgacca agaaccaggt gtccctgacc tgcctggtca agggctttta cccctccgat     1080

atcgccgtgg aatgggagag caatggccag cctgagaaca actacaagac cacacctcct     1140

gtgctggaca gcgacggctc attcttcctg tacagcagac tgaccgtgga caagagcaga     1200

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     1260

acccagaagt ctctgagcct gagctga                                         1287


<210>  313
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProC1718

<400>  313

Ile Ser Tyr Asp Ser Pro Asp Tyr Thr Asp Glu Ser Cys Thr Phe Lys 
1               5                   10                  15      


Ile Ser Leu Arg Asn Phe Arg Ser Ile Leu Ser Trp Glu Leu Lys Asn 
            20                  25                  30          


His Ser Ile Val Pro Thr His Tyr Thr Leu Leu Tyr Thr Ile Met Ser 
        35                  40                  45              


Lys Pro Glu Asp Leu Lys Val Val Lys Asn Cys Ala Asn Thr Thr Arg 
    50                  55                  60                  


Ser Phe Cys Asp Leu Thr Asp Glu Trp Arg Ser Thr His Glu Ala Tyr 
65                  70                  75                  80  


Val Thr Val Leu Glu Gly Phe Ser Gly Asn Thr Thr Leu Phe Ser Cys 
                85                  90                  95      


Ser His Asn Phe Trp Leu Ala Ile Asp Met Ser Phe Glu Pro Pro Glu 
            100                 105                 110         


Phe Glu Ile Val Gly Phe Thr Asn His Ile Asn Val Met Val Lys Phe 
        115                 120                 125             


Pro Ser Ile Val Glu Glu Glu Leu Gln Phe Asp Leu Ser Leu Val Ile 
    130                 135                 140                 


Glu Glu Gln Ser Glu Gly Ile Val Lys Lys His Lys Pro Glu Ile Lys 
145                 150                 155                 160 


Gly Asn Met Ser Gly Asn Phe Thr Tyr Ile Ile Asp Lys Leu Ile Pro 
                165                 170                 175     


Asn Thr Asn Tyr Cys Val Ser Val Tyr Leu Glu His Ser Asp Glu Gln 
            180                 185                 190         


Ala Val Ile Lys Ser Pro Leu Lys Cys Thr Leu Leu Pro Pro Gly Gln 
        195                 200                 205             


Glu Ser Glu Ser Ala Glu Ser Ala Lys Gly Gly Gly Gly Ser His His 
    210                 215                 220                 


His His His His His His 
225                 230 


<210>  314
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProC1976

<400>  314

Asp Asn Ile Gly Ser Gly Gly Ser Cys Asp Leu Pro Gln Thr His Ser 
1               5                   10                  15      


Leu Gly Ser Arg Arg Thr Leu Met Leu Leu Ala Gln Met Arg Arg Ile 
            20                  25                  30          


Ser Leu Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln 
        35                  40                  45              


Glu Glu Phe Gly Asn Gln Phe Gln Lys Ala Glu Thr Ile Pro Val Leu 
    50                  55                  60                  


His Glu Met Ile Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp Ser 
65                  70                  75                  80  


Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu 
                85                  90                  95      


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Gly Val Gly 
            100                 105                 110         


Val Thr Glu Thr Pro Leu Met Lys Glu Asp Ser Ile Leu Ala Val Arg 
        115                 120                 125             


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Lys Glu Lys Lys Tyr Ser 
    130                 135                 140                 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
145                 150                 155                 160 


Leu Ser Thr Asn Leu Gln Glu Ser Leu Arg Ser Lys Glu Leu Ser Gly 
                165                 170                 175     


Arg Ser 
        


<210>  315
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable moiety

<400>  315

Leu Ser Gly Arg Ser Asn Ile 
1               5           


<210>  316
<211>  391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProC440

<400>  316

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu Ser Gly Arg Ser Asp Asn Ile Cys Pro Pro Cys 
                165                 170                 175     


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            180                 185                 190         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        195                 200                 205             


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
    210                 215                 220                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
225                 230                 235                 240 


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                245                 250                 255     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            260                 265                 270         


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        275                 280                 285             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
    290                 295                 300                 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
305                 310                 315                 320 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                325                 330                 335     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            340                 345                 350         


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        355                 360                 365             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    370                 375                 380                 


Gln Lys Ser Leu Ser Leu Ser 
385                 390     


<210>  317
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  317

Glu Ser Lys Tyr Gly Pro Pro 
1               5           


<210>  318
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human IgG Fc with a knob mutation

<400>  318

Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
        35                  40                  45              


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Cys Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
    210                 215                 220     


<210>  319
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human IgG Fc with a hole mutation

<400>  319

Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
        35                  40                  45              


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro 
        115                 120                 125             


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Val Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
    210                 215                 220     


<210>  320
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  stub moiety

<400>  320

Ser Asp Asn Ile 
1               


<210>  321
<211>  430
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProC732

<400>  321

Gln Ser Gly Gln Thr Asp Val Asp Tyr Tyr Arg Glu Trp Ser Trp Thr 
1               5                   10                  15      


Gln Val Ser Gly Ser Ser Gly Gly Ser Leu Ser Gly Arg Ser Asp Asn 
            20                  25                  30          


Ile Gly Ser Gly Gly Ser Cys Asp Leu Pro Gln Thr His Ser Leu Gly 
        35                  40                  45              


Ser Arg Arg Thr Leu Met Leu Leu Ala Gln Met Arg Arg Ile Ser Leu 
    50                  55                  60                  


Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu Glu 
65                  70                  75                  80  


Phe Gly Asn Gln Phe Gln Lys Ala Glu Thr Ile Pro Val Leu His Glu 
                85                  90                  95      


Met Ile Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala 
            100                 105                 110         


Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln 
        115                 120                 125             


Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Gly Val Gly Val Thr 
    130                 135                 140                 


Glu Thr Pro Leu Met Lys Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr 
145                 150                 155                 160 


Phe Gln Arg Ile Thr Leu Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys 
                165                 170                 175     


Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser Leu Ser 
            180                 185                 190         


Thr Asn Leu Gln Glu Ser Leu Arg Ser Lys Glu Leu Ser Gly Arg Ser 
        195                 200                 205             


Asp Asn Ile Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
    210                 215                 220                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
225                 230                 235                 240 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                245                 250                 255     


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            260                 265                 270         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        275                 280                 285             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    290                 295                 300                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
305                 310                 315                 320 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                325                 330                 335     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            340                 345                 350         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        355                 360                 365             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    370                 375                 380                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
385                 390                 395                 400 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                405                 410                 415     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            420                 425                 430 


<210>  322
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProC733

<400>  322

Gln Ser Gly Gln Thr Asp Val Asp Tyr Tyr Arg Glu Trp Ser Trp Thr 
1               5                   10                  15      


Gln Val Ser Gly Ser Ser Gly Gly Ser Leu Ser Gly Arg Ser Asp Asn 
            20                  25                  30          


Ile Gly Ser Gly Gly Ser Cys Asp Leu Pro Gln Thr His Ser Leu Gly 
        35                  40                  45              


Ser Arg Arg Thr Leu Met Leu Leu Ala Gln Met Arg Arg Ile Ser Leu 
    50                  55                  60                  


Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu Glu 
65                  70                  75                  80  


Phe Gly Asn Gln Phe Gln Lys Ala Glu Thr Ile Pro Val Leu His Glu 
                85                  90                  95      


Met Ile Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala 
            100                 105                 110         


Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln 
        115                 120                 125             


Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Gly Val Gly Val Thr 
    130                 135                 140                 


Glu Thr Pro Leu Met Lys Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr 
145                 150                 155                 160 


Phe Gln Arg Ile Thr Leu Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys 
                165                 170                 175     


Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser Leu Ser 
            180                 185                 190         


Thr Asn Leu Gln Glu Ser Leu Arg Ser Lys Glu Glu Ser Lys Tyr Gly 
        195                 200                 205             


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
    210                 215                 220                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
225                 230                 235                 240 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
                245                 250                 255     


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            260                 265                 270         


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
        275                 280                 285             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    290                 295                 300                 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
305                 310                 315                 320 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                325                 330                 335     


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
            340                 345                 350         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        355                 360                 365             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    370                 375                 380                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
385                 390                 395                 400 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                405                 410                 415     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            420                 425                 


<210>  323
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFNa-2b masking peptide

<400>  323

Thr Asp Val Asp Tyr Tyr Arg Glu Trp Ser Trp Thr Gln Val Ser 
1               5                   10                  15  


<210>  324
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  324

Gly Ser Ser Gly Gly Ser 
1               5       


<210>  325
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  325

Glu Ser Lys Tyr 
1               


<210>  326
<211>  407
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProC286

<400>  326

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Ser Gly Gly Gly Gly Ser Gly Arg Ser Asp Asn Ile Gly Gly 
225                 230                 235                 240 


Gly Ser Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr 
                245                 250                 255     


Leu Met Leu Leu Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu 
            260                 265                 270         


Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln 
        275                 280                 285             


Phe Gln Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln 
    290                 295                 300                 


Ile Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu 
305                 310                 315                 320 


Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp 
                325                 330                 335     


Leu Glu Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu 
            340                 345                 350         


Met Lys Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile 
        355                 360                 365             


Thr Leu Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val 
    370                 375                 380                 


Val Arg Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln 
385                 390                 395                 400 


Glu Ser Leu Arg Ser Lys Glu 
                405         


<210>  327
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  327

Ser Gly Gly Gly 
1               


<210>  328
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated IFNa-2b

<400>  328

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Ile Met Arg Ser 
145                 150 


<210>  329
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFNa-2b L130P mutant

<400>  329

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu 
        115                 120                 125             


Tyr Pro Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu 
                165 


<210>  330
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal sequence

<400>  330

Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
1               5                   10  


<210>  331
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  331

Ile Ala Tyr Leu Glu Tyr Tyr Glu His Leu His Met Ala Tyr Gly 
1               5                   10                  15  


<210>  332
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  332

Thr Asp Val Asp Tyr Tyr Arg Glu Trp Cys Trp Thr Gln Val Ser 
1               5                   10                  15  


<210>  333
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  333

Phe Pro Leu Asn Thr Phe Asp Leu Val His Glu Leu Leu Ser Arg 
1               5                   10                  15  


<210>  334
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  334

Phe Leu Asn Asp Ile His Arg Phe Leu His Trp Thr Asp Leu Met 
1               5                   10                  15  


<210>  335
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  335

Pro Tyr Thr Phe Val Glu Gln Val Glu Tyr Trp Leu His Ala Thr 
1               5                   10                  15  


<210>  336
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  336

Ala Cys Val Ile His Phe Leu Asp Arg Ile Ser Asn Ile Leu Glu 
1               5                   10                  15  


<210>  337
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  337

Phe Cys Tyr Ile Ala Ala Phe Ser Ala Met Gln Arg Gln Ser Cys 
1               5                   10                  15  


<210>  338
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  338

Pro Leu Tyr Leu Pro Glu Ile Gly Trp Met Phe Gly Leu Pro Thr 
1               5                   10                  15  


<210>  339
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  339

Thr Val Leu Val Ile Pro Asp Leu His Tyr Leu Tyr Val Asp Arg 
1               5                   10                  15  


<210>  340
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  340

Phe Ile Asn Asn Val Glu Thr Ala Leu Asp Thr Ile Tyr Asn Leu 
1               5                   10                  15  


<210>  341
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  341

Ser Ala Lys His Leu His Pro Gly Arg Leu Pro Pro Met Thr Lys 
1               5                   10                  15  


<210>  342
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  342

Ala Thr Met Tyr Ala Tyr Leu Glu Arg Leu Glu Ala Ile Leu Ser 
1               5                   10                  15  


<210>  343
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  343

Ile Tyr Pro Leu Asp Ala Leu Leu Arg His Leu Asn Ser Leu Cys 
1               5                   10                  15  


<210>  344
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  344

Cys Phe Pro Thr Val Val Trp Arg Glu Leu Tyr Asn Leu Tyr Gly 
1               5                   10                  15  


<210>  345
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  345

Asn Leu Asp Phe Tyr Leu Asn His Leu Tyr Asn Thr Leu Ala Gly 
1               5                   10                  15  


<210>  346
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  346

Asp Phe Ile Asn Ser Met Arg Ser His Leu Gln Ser Ser Asp Gln 
1               5                   10                  15  


<210>  347
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  347

Glu Pro Lys Cys Ser Phe Cys Ser Pro Leu Ile Val Pro Ser Pro 
1               5                   10                  15  


<210>  348
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  348

Pro Asn Cys Ile Glu Ser Phe Leu Ser Ser Ile His Asp Ser Leu 
1               5                   10                  15  


<210>  349
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  349

Thr Asp Asn Ala Leu Phe Leu Glu Thr Val Gln His Tyr Leu Tyr 
1               5                   10                  15  


<210>  350
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  350

Cys Tyr Pro Ser Ile Ser Trp Leu Phe Ala Asp Ala Pro Arg Asn 
1               5                   10                  15  


<210>  351
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  351

Glu Leu Thr Gln Leu Leu Asn Ala Leu Val Asp Val Arg Asn Cys 
1               5                   10                  15  


<210>  352
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  352

Leu Leu Ser Ser Phe Val Glu Thr Met Ser Ser Ile Leu Thr Cys 
1               5                   10                  15  


<210>  353
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  353

Tyr Leu Leu Arg Leu Pro Ser Leu Glu Glu Leu Trp Gly Pro Ser 
1               5                   10                  15  


<210>  354
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  354

Ala Thr Cys Tyr Ile Ile Asn His Trp Val Glu Arg Tyr Ile Ile 
1               5                   10                  15  


<210>  355
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  355

Ile Ala Tyr Leu Glu Tyr Tyr Glu His Leu His Met Ala Tyr 
1               5                   10                  


<210>  356
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  356

Arg Val Thr Cys Asp Asp Tyr Tyr Tyr Gly Phe Gly Cys Asn Lys Phe 
1               5                   10                  15      


Gly Arg Pro Ala 
            20  


<210>  357
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  357

Met Leu Ala Val Val Gly Ala Ala Ala Leu Val Leu Val Ala Gly Ala 
1               5                   10                  15      


Pro Trp Val Leu Pro Ser Ala Ala Gly Gly Glu Asn Leu Lys Pro Pro 
            20                  25                  30          


Glu Asn Ile Asp Val Tyr Ile Ile Asp Asp Asn Tyr Thr Leu Lys Trp 
        35                  40                  45              


Ser Ser His Gly Glu Ser Met Gly Ser Val Thr Phe Ser Ala Glu Tyr 
    50                  55                  60                  


Arg Thr Lys Asp Glu Ala Lys Trp Leu Lys Val Pro Glu Cys Gln His 
65                  70                  75                  80  


Thr Thr Thr Thr Lys Cys Glu Phe Ser Leu Leu Asp Thr Asn Val Tyr 
                85                  90                  95      


Ile Lys Thr Gln Phe Arg Val Arg Ala Glu Glu Gly Asn Ser Thr Ser 
            100                 105                 110         


Ser Trp Asn Glu Val Asp Pro Phe Ile Pro Phe Tyr Thr Ala His Met 
        115                 120                 125             


Ser Pro Pro Glu Val Arg Leu Glu Ala Glu Asp Lys Ala Ile Leu Val 
    130                 135                 140                 


His Ile Ser Pro Pro Gly Gln Asp Gly Asn Met Trp Ala Leu Glu Lys 
145                 150                 155                 160 


Pro Ser Phe Ser Tyr Thr Ile Arg Ile Trp Gln Lys Ser Ser Ser Asp 
                165                 170                 175     


Lys Lys Thr Ile Asn Ser Thr Tyr Tyr Val Glu Lys Ile Pro Glu Leu 
            180                 185                 190         


Leu Pro Glu Thr Thr Tyr Cys Leu Glu Val Lys Ala Ile His Pro Ser 
        195                 200                 205             


Leu Lys Lys His Ser Asn Tyr Ser Thr Val Gln Cys Ile Ser Thr Thr 
    210                 215                 220                 


Val Ala Asn Lys Met Pro Val Pro Gly Asn Leu Gln Val Asp Ala Gln 
225                 230                 235                 240 


Gly Lys Ser Tyr Val Leu Lys Trp Asp Tyr Ile Ala Ser Ala Asp Val 
                245                 250                 255     


Leu Phe Arg Ala Gln Trp Leu Pro Gly Tyr Ser Lys Ser Ser Ser Gly 
            260                 265                 270         


Ser Arg Ser Asp Lys Trp Lys Pro Ile Pro Thr Cys Ala Asn Val Gln 
        275                 280                 285             


Thr Thr His Cys Val Phe Ser Gln Asp Thr Val Tyr Thr Gly Thr Phe 
    290                 295                 300                 


Phe Leu His Val Gln Ala Ser Glu Gly Asn His Thr Ser Phe Trp Ser 
305                 310                 315                 320 


Glu Glu Lys Phe Ile Asp Ser Gln Lys His Ile Leu Pro Pro Pro Pro 
                325                 330                 335     


Val Ile Thr Val Thr Ala Met Ser Asp Thr Leu Leu Val Tyr Val Asn 
            340                 345                 350         


Cys Gln Asp Ser Thr Cys Asp Gly Leu Asn Tyr Glu Ile Ile Phe Trp 
        355                 360                 365             


Glu Asn Thr Ser Asn Thr Lys Ile Ser Met Glu Lys Asp Gly Pro Glu 
    370                 375                 380                 


Phe Thr Leu Lys Asn Leu Gln Pro Leu Thr Val Tyr Cys Val Gln Ala 
385                 390                 395                 400 


Arg Val Leu Phe Arg Ala Leu Leu Asn Lys Thr Ser Asn Phe Ser Glu 
                405                 410                 415     


Lys Leu Cys Glu Lys Thr Arg Pro Gly Ser Phe Ser Thr 
            420                 425                 


<210>  358
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  358

Met Leu Leu Ser Gln Asn Ala Phe Ile Phe Arg Ser Leu Asn Leu Val 
1               5                   10                  15      


Leu Met Val Tyr Ile Ser Leu Val Phe Gly Ile Ser Tyr Asp Ser Pro 
            20                  25                  30          


Asp Tyr Thr Asp Glu Ser Cys Thr Phe Lys Ile Ser Leu Arg Asn Phe 
        35                  40                  45              


Arg Ser Ile Leu Ser Trp Glu Leu Lys Asn His Ser Ile Val Pro Thr 
    50                  55                  60                  


His Tyr Thr Leu Leu Tyr Thr Ile Met Ser Lys Pro Glu Asp Leu Lys 
65                  70                  75                  80  


Val Val Lys Asn Cys Ala Asn Thr Thr Arg Ser Phe Cys Asp Leu Thr 
                85                  90                  95      


Asp Glu Trp Arg Ser Thr His Glu Ala Tyr Val Thr Val Leu Glu Gly 
            100                 105                 110         


Phe Ser Gly Asn Thr Thr Leu Phe Ser Cys Ser His Asn Phe Trp Leu 
        115                 120                 125             


Ala Ile Asp Met Ser Phe Glu Pro Pro Glu Phe Glu Ile Val Gly Phe 
    130                 135                 140                 


Thr Asn His Ile Asn Val Met Val Lys Phe Pro Ser Ile Val Glu Glu 
145                 150                 155                 160 


Glu Leu Gln Phe Asp Leu Ser Leu Val Ile Glu Glu Gln Ser Glu Gly 
                165                 170                 175     


Ile Val Lys Lys His Lys Pro Glu Ile Lys Gly Asn Met Ser Gly Asn 
            180                 185                 190         


Phe Thr Tyr Ile Ile Asp Lys Leu Ile Pro Asn Thr Asn Tyr Cys Val 
        195                 200                 205             


Ser Val Tyr Leu Glu His Ser Asp Glu Gln Ala Val Ile Lys Ser Pro 
    210                 215                 220                 


Leu Lys Cys Thr Leu Leu Pro Pro Gly Gln Glu Ser Glu Ser Ala Glu 
225                 230                 235                 240 


Ser Ala Lys 
            


<210>  359
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  359

Met Met Val Val Leu Leu Gly Ala Thr Thr Leu Val Leu Val Ala Val 
1               5                   10                  15      


Ala Pro Trp Val Leu Ser Ala Ala Ala Gly Gly Lys Asn Leu Lys Ser 
            20                  25                  30          


Pro Gln Lys Val Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg 
        35                  40                  45              


Trp Asn Arg Ser Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp 
    50                  55                  60                  


Tyr Gln Lys Thr Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln 
65                  70                  75                  80  


Asn Ile Thr Ser Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val 
                85                  90                  95      


Tyr Glu Glu Ile Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser 
            100                 105                 110         


Ser Trp Tyr Glu Val Asp Ser Phe Thr Pro Phe Arg Lys Ala Gln Ile 
        115                 120                 125             


Gly Pro Pro Glu Val His Leu Glu Ala Glu Asp Lys Ala Ile Val Ile 
    130                 135                 140                 


His Ile Ser Pro Gly Thr Lys Asp Ser Val Met Trp Ala Leu Asp Gly 
145                 150                 155                 160 


Leu Ser Phe Thr Tyr Ser Leu Val Ile Trp Lys Asn Ser Ser Gly Val 
                165                 170                 175     


Glu Glu Arg Ile Glu Asn Ile Tyr Ser Arg His Lys Ile Tyr Lys Leu 
            180                 185                 190         


Ser Pro Glu Thr Thr Tyr Cys Leu Lys Val Lys Ala Ala Leu Leu Thr 
        195                 200                 205             


Ser Trp Lys Ile Gly Val Tyr Ser Pro Val His Cys Ile Lys Thr Thr 
    210                 215                 220                 


Val Glu Asn Glu Leu Pro Pro Pro Glu Asn Ile Glu Val Ser Val Gln 
225                 230                 235                 240 


Asn Gln Asn Tyr Val Leu Lys Trp Asp Tyr Thr Tyr Ala Asn Met Thr 
                245                 250                 255     


Phe Gln Val Gln Trp Leu His Ala Phe Leu Lys Arg Asn Pro Gly Asn 
            260                 265                 270         


His Leu Tyr Lys Trp Lys Gln Ile Pro Asp Cys Glu Asn Val Lys Thr 
        275                 280                 285             


Thr Gln Cys Val Phe Pro Gln Asn Val Phe Gln Lys Gly Ile Tyr Leu 
    290                 295                 300                 


Leu Arg Val Gln Ala Ser Asp Gly Asn Asn Thr Ser Phe Trp Ser Glu 
305                 310                 315                 320 


Glu Ile Lys Phe Asp Thr Glu Ile Gln Ala Phe Leu Leu Pro Pro Val 
                325                 330                 335     


Phe Asn Ile Arg Ser Leu Ser Asp Ser Phe His Ile Tyr Ile Gly Ala 
            340                 345                 350         


Pro Lys Gln Ser Gly Asn Thr Pro Val Ile Gln Asp Tyr Pro Leu Ile 
        355                 360                 365             


Tyr Glu Ile Ile Phe Trp Glu Asn Thr Ser Asn Ala Glu Arg Lys Ile 
    370                 375                 380                 


Ile Glu Lys Lys Thr Asp Val Thr Val Pro Asn Leu Lys Pro Leu Thr 
385                 390                 395                 400 


Val Tyr Cys Val Lys Ala Arg Ala His Thr Met Asp Glu Lys Leu Asn 
                405                 410                 415     


Lys Ser Ser Val Phe Ser Asp Ala Val Cys Glu Lys Thr Lys Pro Gly 
            420                 425                 430         


Asn Thr Ser Lys 
        435     


<210>  360
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  360

Met Arg Ser Arg Cys Thr Val Ser Ala Val Gly Leu Leu Ser Leu Cys 
1               5                   10                  15      


Leu Val Val Ser Ala Ser Leu Glu Thr Ile Thr Pro Ser Ala Phe Asp 
            20                  25                  30          


Gly Tyr Pro Asp Glu Pro Cys Thr Ile Asn Ile Thr Ile Arg Asn Ser 
        35                  40                  45              


Arg Leu Ile Leu Ser Trp Glu Leu Glu Asn Lys Ser Gly Pro Pro Ala 
    50                  55                  60                  


Asn Tyr Thr Leu Trp Tyr Thr Val Met Ser Lys Asp Glu Asn Leu Thr 
65                  70                  75                  80  


Lys Val Lys Asn Cys Ser Asp Thr Thr Lys Ser Ser Cys Asp Val Thr 
                85                  90                  95      


Asp Lys Trp Leu Glu Gly Met Glu Ser Tyr Val Val Ala Ile Val Ile 
            100                 105                 110         


Val His Arg Gly Asp Leu Thr Val Cys Arg Cys Ser Asp Tyr Ile Val 
        115                 120                 125             


Pro Ala Asn Ala Pro Leu Glu Pro Pro Glu Phe Glu Ile Val Gly Phe 
    130                 135                 140                 


Thr Asp His Ile Asn Val Thr Met Glu Phe Pro Pro Val Thr Ser Lys 
145                 150                 155                 160 


Ile Ile Gln Glu Lys Met Lys Thr Thr Pro Phe Val Ile Lys Glu Gln 
                165                 170                 175     


Ile Gly Asp Ser Val Arg Lys Lys His Glu Pro Lys Val Asn Asn Val 
            180                 185                 190         


Thr Gly Asn Phe Thr Phe Val Leu Arg Asp Leu Leu Pro Lys Thr Asn 
        195                 200                 205             


Tyr Cys Val Ser Leu Tyr Phe Asp Asp Asp Pro Ala Ile Lys Ser Pro 
    210                 215                 220                 


Leu Lys Cys Ile Val Leu Gln Pro Gly Gln Glu Ser Gly Leu Ser Glu 
225                 230                 235                 240 


Ser Ala 
        


<210>  361
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask


<220>
<221>  misc_feature
<222>  (10)..(17)
<223>  X may be any amino acid

<400>  361

Thr Asp Val Asp Tyr Tyr Arg Glu Trp Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa 
    


<210>  362
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  362

Gly Ser Gly Thr Asp Val Asp Tyr Tyr Arg Glu Trp Ser Trp Thr Gln 
1               5                   10                  15      


Val 
    


<210>  363
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  363

Gly Ser Gly Thr Asp Val Asp Tyr Tyr Arg Glu Trp Ser Trp Thr Gln 
1               5                   10                  15      


Val Ser 
        


<210>  364
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  364

Thr Asp Val Asp Tyr Tyr Arg Glu Trp Ser Trp Thr Gln Val 
1               5                   10                  


<210>  365
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal sequence

<400>  365

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
1               5                   10          


<210>  366
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  366

Ala Leu Thr Ser Thr Glu Asp Pro Glu Pro Pro Ser Val Pro Val Pro 
1               5                   10                  15      


Thr Asn Val Leu Ile Lys Ser Tyr Asn Leu Asn Pro Val Val Cys Trp 
            20                  25                  30          


Glu Tyr Gln Asn Met Ser Gln Thr Pro Ile Phe Thr Val Gln Val Lys 
        35                  40                  45              


Val Tyr Ser Gly Ser Trp Thr Asp Ser Cys Thr Asn Ile Ser Asp His 
    50                  55                  60                  


Cys Cys Asn Ile Tyr Glu Gln Ile Met Tyr Pro Asp Val Ser Ala Trp 
65                  70                  75                  80  


Ala Arg Val Lys Ala Lys Val Gly Gln Lys Glu Ser Asp Tyr Ala Arg 
                85                  90                  95      


Ser Lys Glu Phe Leu Met Cys Leu Lys Gly Lys Val Gly Pro Pro Gly 
            100                 105                 110         


Leu Glu Ile Arg Arg Lys Lys Glu Glu Gln Leu Ser Val Leu Val Phe 
        115                 120                 125             


His Pro Glu Val Val Val Asn Gly Glu Ser Gln Gly Thr Met Phe Gly 
    130                 135                 140                 


Asp Gly Ser Thr Cys Tyr Thr Phe Asp Tyr Thr Val Tyr Val Glu His 
145                 150                 155                 160 


Asn Arg Ser Gly Glu Ile Leu His Thr Lys His Thr Val Glu Lys Glu 
                165                 170                 175     


Glu Cys Asn Glu Thr Leu Cys Glu Leu Asn Ile Ser Val Ser Thr Leu 
            180                 185                 190         


Asp Ser Arg Tyr Cys Leu Ser Val Asp Gly Ile Ser Ser Phe Trp Gln 
        195                 200                 205             


Val Arg Thr Glu Lys Ser Lys Asp Val Cys Ile Pro Pro Phe His Asp 
    210                 215                 220                 


Asp Arg Lys Asp Ser 
225                 


<210>  367
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  367

Ala Ser Ser Pro Asp Ser Phe Ser Gln Leu Ala Ala Pro Leu Asn Pro 
1               5                   10                  15      


Arg Leu His Leu Tyr Asn Asp Glu Gln Ile Leu Thr Trp Glu Pro Ser 
            20                  25                  30          


Pro Ser Ser Asn Asp Pro Arg Pro Val Val Tyr Gln Val Glu Tyr Ser 
        35                  40                  45              


Phe Ile Asp Gly Ser Trp His Arg Leu Leu Glu Pro Asn Cys Thr Asp 
    50                  55                  60                  


Ile Thr Glu Thr Lys Cys Asp Leu Thr Gly Gly Gly Arg Leu Lys Leu 
65                  70                  75                  80  


Phe Pro His Pro Phe Thr Val Phe Leu Arg Val Arg Ala Lys Arg Gly 
                85                  90                  95      


Asn Leu Thr Ser Lys Trp Val Gly Leu Glu Pro Phe Gln His Tyr Glu 
            100                 105                 110         


Asn Val Thr Val Gly Pro Pro Lys Asn Ile Ser Val Thr Pro Gly Lys 
        115                 120                 125             


Gly Ser Leu Val Ile His Phe Ser Pro Pro Phe Asp Val Phe His Gly 
    130                 135                 140                 


Ala Thr Phe Gln Tyr Leu Val His Tyr Trp Glu Lys Ser Glu Thr Gln 
145                 150                 155                 160 


Gln Glu Gln Val Glu Gly Pro Phe Lys Ser Asn Ser Ile Val Leu Gly 
                165                 170                 175     


Asn Leu Lys Pro Tyr Arg Val Tyr Cys Leu Gln Thr Glu Ala Gln Leu 
            180                 185                 190         


Ile Leu Lys Asn Lys Lys Ile Arg Pro His Gly Leu Leu Ser Asn Val 
        195                 200                 205             


Ser Cys His Glu Thr Thr Ala Asn Ala Ser Ala Arg Leu Gln Gln Val 
    210                 215                 220                 


Ile Leu Ile Pro Leu Gly Ile Phe Ala Leu Leu Leu Gly Leu Thr Gly 
225                 230                 235                 240 


Ala Cys Phe Thr Leu Phe Leu Lys Tyr Gln Ser Arg Val Lys Tyr Trp 
                245                 250                 255     


Phe Gln Ala Pro Pro Asn Ile Pro Glu Gln Ile Glu Glu Tyr Leu Lys 
            260                 265                 270         


Asp Pro Asp Gln Phe Ile Leu Glu Val Leu Asp Lys Asp Gly Ser Pro 
        275                 280                 285             


Lys Glu Asp Ser Trp Asp Ser Val Ser Ile Ile Ser Ser Pro Glu Lys 
    290                 295                 300                 


Glu Arg Asp Asp Val Leu Gln Thr Pro 
305                 310             


<210>  368
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  368

Glu Met Gly Thr Ala Asp Leu Gly Pro Ser Ser Val Pro Thr Pro Thr 
1               5                   10                  15      


Asn Val Thr Ile Glu Ser Tyr Asn Met Asn Pro Ile Val Tyr Trp Glu 
            20                  25                  30          


Tyr Gln Ile Met Pro Gln Val Pro Val Phe Thr Val Glu Val Lys Asn 
        35                  40                  45              


Tyr Gly Val Lys Asn Ser Glu Trp Ile Asp Ala Cys Ile Asn Ile Ser 
    50                  55                  60                  


His His Tyr Cys Asn Ile Ser Asp His Val Gly Asp Pro Ser Asn Ser 
65                  70                  75                  80  


Leu Trp Val Arg Val Lys Ala Arg Val Gly Gln Lys Glu Ser Ala Tyr 
                85                  90                  95      


Ala Lys Ser Glu Glu Phe Ala Val Cys Arg Asp Gly Lys Ile Gly Pro 
            100                 105                 110         


Pro Lys Leu Asp Ile Arg Lys Glu Glu Lys Gln Ile Met Ile Asp Ile 
        115                 120                 125             


Phe His Pro Ser Val Phe Val Asn Gly Asp Glu Gln Glu Val Asp Tyr 
    130                 135                 140                 


Asp Pro Glu Thr Thr Cys Tyr Ile Arg Val Tyr Asn Val Tyr Val Arg 
145                 150                 155                 160 


Met Asn Gly Ser Glu Ile Gln Tyr Lys Ile Leu Thr Gln Lys Glu Asp 
                165                 170                 175     


Asp Cys Asp Glu Ile Gln Cys Gln Leu Ala Ile Pro Val Ser Ser Leu 
            180                 185                 190         


Asn Ser Gln Tyr Cys Val Ser Ala Glu Gly Val Leu His Val Trp Gly 
        195                 200                 205             


Val Thr Thr Glu Lys Ser Lys Glu Val Cys Ile Thr Ile Phe Asn Ser 
    210                 215                 220                 


Ser Ile Lys Gly 
225             


<210>  369
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  369

Ser Gln Leu Pro Ala Pro Gln His Pro Lys Ile Arg Leu Tyr Asn Ala 
1               5                   10                  15      


Glu Gln Val Leu Ser Trp Glu Pro Val Ala Leu Ser Asn Ser Thr Arg 
            20                  25                  30          


Pro Val Val Tyr Gln Val Gln Phe Lys Tyr Thr Asp Ser Lys Trp Phe 
        35                  40                  45              


Thr Ala Asp Ile Met Ser Ile Gly Val Asn Cys Thr Gln Ile Thr Ala 
    50                  55                  60                  


Thr Glu Cys Asp Phe Thr Ala Ala Ser Pro Ser Ala Gly Phe Pro Met 
65                  70                  75                  80  


Asp Phe Asn Val Thr Leu Arg Leu Arg Ala Glu Leu Gly Ala Leu His 
                85                  90                  95      


Ser Ala Trp Val Thr Met Pro Trp Phe Gln His Tyr Arg Asn Val Thr 
            100                 105                 110         


Val Gly Pro Pro Glu Asn Ile Glu Val Thr Pro Gly Glu Gly Ser Leu 
        115                 120                 125             


Ile Ile Arg Phe Ser Ser Pro Phe Asp Ile Ala Asp Thr Ser Thr Ala 
    130                 135                 140                 


Phe Phe Cys Tyr Tyr Val His Tyr Trp Glu Lys Gly Gly Ile Gln Gln 
145                 150                 155                 160 


Val Lys Gly Pro Phe Arg Ser Asn Ser Ile Ser Leu Asp Asn Leu Lys 
                165                 170                 175     


Pro Ser Arg Val Tyr Cys Leu Gln Val Gln Ala Gln Leu Leu Trp Asn 
            180                 185                 190         


Lys Ser Asn Ile Phe Arg Val Gly His Leu Ser Asn Ile Ser Cys Tyr 
        195                 200                 205             


Glu Thr Met Ala Asp Ala Ser Thr Glu Leu Gln Gln 
    210                 215                 220 


<210>  370
<211>  639
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-12

<400>  370

Cys Arg Thr Ser Glu Cys Cys Phe Gln Asp Pro Pro Tyr Pro Asp Ala 
1               5                   10                  15      


Asp Ser Gly Ser Ala Ser Gly Pro Arg Asp Leu Arg Cys Tyr Arg Ile 
            20                  25                  30          


Ser Ser Asp Arg Tyr Glu Cys Ser Trp Gln Tyr Glu Gly Pro Thr Ala 
        35                  40                  45              


Gly Val Ser His Phe Leu Arg Cys Cys Leu Ser Ser Gly Arg Cys Cys 
    50                  55                  60                  


Tyr Phe Ala Ala Gly Ser Ala Thr Arg Leu Gln Phe Ser Asp Gln Ala 
65                  70                  75                  80  


Gly Val Ser Val Leu Tyr Thr Val Thr Leu Trp Val Glu Ser Trp Ala 
                85                  90                  95      


Arg Asn Gln Thr Glu Lys Ser Pro Glu Val Thr Leu Gln Leu Tyr Asn 
            100                 105                 110         


Ser Val Lys Tyr Glu Pro Pro Leu Gly Asp Ile Lys Val Ser Lys Leu 
        115                 120                 125             


Ala Gly Gln Leu Arg Met Glu Trp Glu Thr Pro Asp Asn Gln Val Gly 
    130                 135                 140                 


Ala Glu Val Gln Phe Arg His Arg Thr Pro Ser Ser Pro Trp Lys Leu 
145                 150                 155                 160 


Gly Asp Cys Gly Pro Gln Asp Asp Asp Thr Glu Ser Cys Leu Cys Pro 
                165                 170                 175     


Leu Glu Met Asn Val Ala Gln Glu Phe Gln Leu Arg Arg Arg Gln Leu 
            180                 185                 190         


Gly Ser Gln Gly Ser Ser Trp Ser Lys Trp Ser Ser Pro Val Cys Val 
        195                 200                 205             


Pro Pro Glu Asn Pro Pro Gln Pro Gln Val Arg Phe Ser Val Glu Gln 
    210                 215                 220                 


Leu Gly Gln Asp Gly Arg Arg Arg Leu Thr Leu Lys Glu Gln Pro Thr 
225                 230                 235                 240 


Gln Leu Glu Leu Pro Glu Gly Cys Gln Gly Leu Ala Pro Gly Thr Glu 
                245                 250                 255     


Val Thr Tyr Arg Leu Gln Leu His Met Leu Ser Cys Pro Cys Lys Ala 
            260                 265                 270         


Lys Ala Thr Arg Thr Leu His Leu Gly Lys Met Pro Tyr Leu Ser Gly 
        275                 280                 285             


Ala Ala Tyr Asn Val Ala Val Ile Ser Ser Asn Gln Phe Gly Pro Gly 
    290                 295                 300                 


Leu Asn Gln Thr Trp His Ile Pro Ala Asp Thr His Thr Glu Pro Val 
305                 310                 315                 320 


Ala Leu Asn Ile Ser Val Gly Thr Asn Gly Thr Thr Met Tyr Trp Pro 
                325                 330                 335     


Ala Arg Ala Gln Ser Met Thr Tyr Cys Ile Glu Trp Gln Pro Val Gly 
            340                 345                 350         


Gln Asp Gly Gly Leu Ala Thr Cys Ser Leu Thr Ala Pro Gln Asp Pro 
        355                 360                 365             


Asp Pro Ala Gly Met Ala Thr Tyr Ser Trp Ser Arg Glu Ser Gly Ala 
    370                 375                 380                 


Met Gly Gln Glu Lys Cys Tyr Tyr Ile Thr Ile Phe Ala Ser Ala His 
385                 390                 395                 400 


Pro Glu Lys Leu Thr Leu Trp Ser Thr Val Leu Ser Thr Tyr His Phe 
                405                 410                 415     


Gly Gly Asn Ala Ser Ala Ala Gly Thr Pro His His Val Ser Val Lys 
            420                 425                 430         


Asn His Ser Leu Asp Ser Val Ser Val Asp Trp Ala Pro Ser Leu Leu 
        435                 440                 445             


Ser Thr Cys Pro Gly Val Leu Lys Glu Tyr Val Val Arg Cys Arg Asp 
    450                 455                 460                 


Glu Asp Ser Lys Gln Val Ser Glu His Pro Val Gln Pro Thr Glu Thr 
465                 470                 475                 480 


Gln Val Thr Leu Ser Gly Leu Arg Ala Gly Val Ala Tyr Thr Val Gln 
                485                 490                 495     


Val Arg Ala Asp Thr Ala Trp Leu Arg Gly Val Trp Ser Gln Pro Gln 
            500                 505                 510         


Arg Phe Ser Ile Glu Val Gln Val Ser Asp Trp Leu Ile Phe Phe Ala 
        515                 520                 525             


Ser Leu Gly Ser Phe Leu Ser Ile Leu Leu Val Gly Val Leu Gly Tyr 
    530                 535                 540                 


Leu Gly Leu Asn Arg Ala Ala Arg His Leu Cys Pro Pro Leu Pro Thr 
545                 550                 555                 560 


Pro Cys Ala Ser Ser Ala Ile Glu Phe Pro Gly Gly Lys Glu Thr Trp 
                565                 570                 575     


Gln Trp Ile Asn Pro Val Asp Phe Gln Glu Glu Ala Ser Leu Gln Glu 
            580                 585                 590         


Ala Leu Val Val Glu Met Ser Trp Asp Lys Gly Glu Arg Thr Glu Pro 
        595                 600                 605             


Leu Glu Lys Thr Glu Leu Pro Glu Gly Ala Pro Glu Leu Ala Leu Asp 
    610                 615                 620                 


Thr Glu Leu Ser Leu Glu Asp Gly Asp Arg Cys Lys Ala Lys Met 
625                 630                 635                 


<210>  371
<211>  839
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  371

Lys Ile Asp Ala Cys Lys Arg Gly Asp Val Thr Val Lys Pro Ser His 
1               5                   10                  15      


Val Ile Leu Leu Gly Ser Thr Val Asn Ile Thr Cys Ser Leu Lys Pro 
            20                  25                  30          


Arg Gln Gly Cys Phe His Tyr Ser Arg Arg Asn Lys Leu Ile Leu Tyr 
        35                  40                  45              


Lys Phe Asp Arg Arg Ile Asn Phe His His Gly His Ser Leu Asn Ser 
    50                  55                  60                  


Gln Val Thr Gly Leu Pro Leu Gly Thr Thr Leu Phe Val Cys Lys Leu 
65                  70                  75                  80  


Ala Cys Ile Asn Ser Asp Glu Ile Gln Ile Cys Gly Ala Glu Ile Phe 
                85                  90                  95      


Val Gly Val Ala Pro Glu Gln Pro Gln Asn Leu Ser Cys Ile Gln Lys 
            100                 105                 110         


Gly Glu Gln Gly Thr Val Ala Cys Thr Trp Glu Arg Gly Arg Asp Thr 
        115                 120                 125             


His Leu Tyr Thr Glu Tyr Thr Leu Gln Leu Ser Gly Pro Lys Asn Leu 
    130                 135                 140                 


Thr Trp Gln Lys Gln Cys Lys Asp Ile Tyr Cys Asp Tyr Leu Asp Phe 
145                 150                 155                 160 


Gly Ile Asn Leu Thr Pro Glu Ser Pro Glu Ser Asn Phe Thr Ala Lys 
                165                 170                 175     


Val Thr Ala Val Asn Ser Leu Gly Ser Ser Ser Ser Leu Pro Ser Thr 
            180                 185                 190         


Phe Thr Phe Leu Asp Ile Val Arg Pro Leu Pro Pro Trp Asp Ile Arg 
        195                 200                 205             


Ile Lys Phe Gln Lys Ala Ser Val Ser Arg Cys Thr Leu Tyr Trp Arg 
    210                 215                 220                 


Asp Glu Gly Leu Val Leu Leu Asn Arg Leu Arg Tyr Arg Pro Ser Asn 
225                 230                 235                 240 


Ser Arg Leu Trp Asn Met Val Asn Val Thr Lys Ala Lys Gly Arg His 
                245                 250                 255     


Asp Leu Leu Asp Leu Lys Pro Phe Thr Glu Tyr Glu Phe Gln Ile Ser 
            260                 265                 270         


Ser Lys Leu His Leu Tyr Lys Gly Ser Trp Ser Asp Trp Ser Glu Ser 
        275                 280                 285             


Leu Arg Ala Gln Thr Pro Glu Glu Glu Pro Thr Gly Met Leu Asp Val 
    290                 295                 300                 


Trp Tyr Met Lys Arg His Ile Asp Tyr Ser Arg Gln Gln Ile Ser Leu 
305                 310                 315                 320 


Phe Trp Lys Asn Leu Ser Val Ser Glu Ala Arg Gly Lys Ile Leu His 
                325                 330                 335     


Tyr Gln Val Thr Leu Gln Glu Leu Thr Gly Gly Lys Ala Met Thr Gln 
            340                 345                 350         


Asn Ile Thr Gly His Thr Ser Trp Thr Thr Val Ile Pro Arg Thr Gly 
        355                 360                 365             


Asn Trp Ala Val Ala Val Ser Ala Ala Asn Ser Lys Gly Ser Ser Leu 
    370                 375                 380                 


Pro Thr Arg Ile Asn Ile Met Asn Leu Cys Glu Ala Gly Leu Leu Ala 
385                 390                 395                 400 


Pro Arg Gln Val Ser Ala Asn Ser Glu Gly Met Asp Asn Ile Leu Val 
                405                 410                 415     


Thr Trp Gln Pro Pro Arg Lys Asp Pro Ser Ala Val Gln Glu Tyr Val 
            420                 425                 430         


Val Glu Trp Arg Glu Leu His Pro Gly Gly Asp Thr Gln Val Pro Leu 
        435                 440                 445             


Asn Trp Leu Arg Ser Arg Pro Tyr Asn Val Ser Ala Leu Ile Ser Glu 
    450                 455                 460                 


Asn Ile Lys Ser Tyr Ile Cys Tyr Glu Ile Arg Val Tyr Ala Leu Ser 
465                 470                 475                 480 


Gly Asp Gln Gly Gly Cys Ser Ser Ile Leu Gly Asn Ser Lys His Lys 
                485                 490                 495     


Ala Pro Leu Ser Gly Pro His Ile Asn Ala Ile Thr Glu Glu Lys Gly 
            500                 505                 510         


Ser Ile Leu Ile Ser Trp Asn Ser Ile Pro Val Gln Glu Gln Met Gly 
        515                 520                 525             


Cys Leu Leu His Tyr Arg Ile Tyr Trp Lys Glu Arg Asp Ser Asn Ser 
    530                 535                 540                 


Gln Pro Gln Leu Cys Glu Ile Pro Tyr Arg Val Ser Gln Asn Ser His 
545                 550                 555                 560 


Pro Ile Asn Ser Leu Gln Pro Arg Val Thr Tyr Val Leu Trp Met Thr 
                565                 570                 575     


Ala Leu Thr Ala Ala Gly Glu Ser Ser His Gly Asn Glu Arg Glu Phe 
            580                 585                 590         


Cys Leu Gln Gly Lys Ala Asn Trp Met Ala Phe Val Ala Pro Ser Ile 
        595                 600                 605             


Cys Ile Ala Ile Ile Met Val Gly Ile Phe Ser Thr His Tyr Phe Gln 
    610                 615                 620                 


Gln Lys Val Phe Val Leu Leu Ala Ala Leu Arg Pro Gln Trp Cys Ser 
625                 630                 635                 640 


Arg Glu Ile Pro Asp Pro Ala Asn Ser Thr Cys Ala Lys Lys Tyr Pro 
                645                 650                 655     


Ile Ala Glu Glu Lys Thr Gln Leu Pro Leu Asp Arg Leu Leu Ile Asp 
            660                 665                 670         


Trp Pro Thr Pro Glu Asp Pro Glu Pro Leu Val Ile Ser Glu Val Leu 
        675                 680                 685             


His Gln Val Thr Pro Val Phe Arg His Pro Pro Cys Ser Asn Trp Pro 
    690                 695                 700                 


Gln Arg Glu Lys Gly Ile Gln Gly His Gln Ala Ser Glu Lys Asp Met 
705                 710                 715                 720 


Met His Ser Ala Ser Ser Pro Pro Pro Pro Arg Ala Leu Gln Ala Glu 
                725                 730                 735     


Ser Arg Gln Leu Val Asp Leu Tyr Lys Val Leu Glu Ser Arg Gly Ser 
            740                 745                 750         


Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu Pro Ala 
        755                 760                 765             


Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp Asp 
    770                 775                 780                 


Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu Glu 
785                 790                 795                 800 


Pro Gln His Ile Ser Leu Ser Val Phe Pro Ser Ser Ser Leu His Pro 
                805                 810                 815     


Leu Thr Phe Ser Cys Gly Asp Lys Leu Thr Leu Asp Gln Leu Lys Met 
            820                 825                 830         


Arg Cys Asp Ser Leu Met Leu 
        835                 


<210>  372
<211>  851
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  372

Asn Ile Asp Val Cys Lys Leu Gly Thr Val Thr Val Gln Pro Ala Pro 
1               5                   10                  15      


Val Ile Pro Leu Gly Ser Ala Ala Asn Ile Ser Cys Ser Leu Asn Pro 
            20                  25                  30          


Lys Gln Gly Cys Ser His Tyr Pro Ser Ser Asn Glu Leu Ile Leu Leu 
        35                  40                  45              


Lys Phe Val Asn Asp Val Leu Val Glu Asn Leu His Gly Lys Lys Val 
    50                  55                  60                  


His Asp His Thr Gly His Ser Ser Thr Phe Gln Val Thr Asn Leu Ser 
65                  70                  75                  80  


Leu Gly Met Thr Leu Phe Val Cys Lys Leu Asn Cys Ser Asn Ser Gln 
                85                  90                  95      


Lys Lys Pro Pro Val Pro Val Cys Gly Val Glu Ile Ser Val Gly Val 
            100                 105                 110         


Ala Pro Glu Pro Pro Gln Asn Ile Ser Cys Val Gln Glu Gly Glu Asn 
        115                 120                 125             


Gly Thr Val Ala Cys Ser Trp Asn Ser Gly Lys Val Thr Tyr Leu Lys 
    130                 135                 140                 


Thr Asn Tyr Thr Leu Gln Leu Ser Gly Pro Asn Asn Leu Thr Cys Gln 
145                 150                 155                 160 


Lys Gln Cys Phe Ser Asp Asn Arg Gln Asn Cys Asn Arg Leu Asp Leu 
                165                 170                 175     


Gly Ile Asn Leu Ser Pro Asp Leu Ala Glu Ser Arg Phe Ile Val Arg 
            180                 185                 190         


Val Thr Ala Ile Asn Asp Leu Gly Asn Ser Ser Ser Leu Pro His Thr 
        195                 200                 205             


Phe Thr Phe Leu Asp Ile Val Ile Pro Leu Pro Pro Trp Asp Ile Arg 
    210                 215                 220                 


Ile Asn Phe Leu Asn Ala Ser Gly Ser Arg Gly Thr Leu Gln Trp Glu 
225                 230                 235                 240 


Asp Glu Gly Gln Val Val Leu Asn Gln Leu Arg Tyr Gln Pro Leu Asn 
                245                 250                 255     


Ser Thr Ser Trp Asn Met Val Asn Ala Thr Asn Ala Lys Gly Lys Tyr 
            260                 265                 270         


Asp Leu Arg Asp Leu Arg Pro Phe Thr Glu Tyr Glu Phe Gln Ile Ser 
        275                 280                 285             


Ser Lys Leu His Leu Ser Gly Gly Ser Trp Ser Asn Trp Ser Glu Ser 
    290                 295                 300                 


Leu Arg Thr Arg Thr Pro Glu Glu Glu Pro Val Gly Ile Leu Asp Ile 
305                 310                 315                 320 


Trp Tyr Met Lys Gln Asp Ile Asp Tyr Asp Arg Gln Gln Ile Ser Leu 
                325                 330                 335     


Phe Trp Lys Ser Leu Asn Pro Ser Glu Ala Arg Gly Lys Ile Leu His 
            340                 345                 350         


Tyr Gln Val Thr Leu Gln Glu Val Thr Lys Lys Thr Thr Leu Gln Asn 
        355                 360                 365             


Thr Thr Arg His Thr Ser Trp Thr Arg Val Ile Pro Arg Thr Gly Ala 
    370                 375                 380                 


Trp Thr Ala Ser Val Ser Ala Ala Asn Ser Lys Gly Ala Ser Ala Pro 
385                 390                 395                 400 


Thr His Ile Asn Ile Val Asp Leu Cys Gly Thr Gly Leu Leu Ala Pro 
                405                 410                 415     


His Gln Val Ser Ala Lys Ser Glu Asn Met Asp Asn Ile Leu Val Thr 
            420                 425                 430         


Trp Gln Pro Pro Lys Lys Ala Asp Ser Ala Val Arg Glu Tyr Ile Val 
        435                 440                 445             


Glu Trp Arg Ala Leu Gln Pro Gly Ser Ile Thr Lys Phe Pro Pro His 
    450                 455                 460                 


Trp Leu Arg Ile Pro Pro Asp Asn Met Ser Ala Leu Ile Ser Glu Asn 
465                 470                 475                 480 


Ile Lys Pro Tyr Ile Cys Tyr Glu Ile Arg Val His Ala Leu Ser Glu 
                485                 490                 495     


Ser Gln Gly Gly Cys Ser Ser Ile Arg Gly Asp Ser Lys His Lys Ala 
            500                 505                 510         


Pro Val Ser Gly Pro His Ile Thr Ala Ile Thr Glu Lys Lys Glu Arg 
        515                 520                 525             


Leu Phe Ile Ser Trp Thr His Ile Pro Phe Pro Glu Gln Arg Gly Cys 
    530                 535                 540                 


Ile Leu His Tyr Arg Ile Tyr Trp Lys Glu Arg Asp Ser Thr Ala Gln 
545                 550                 555                 560 


Pro Glu Leu Cys Glu Ile Gln Tyr Arg Arg Ser Gln Asn Ser His Pro 
                565                 570                 575     


Ile Ser Ser Leu Gln Pro Arg Val Thr Tyr Val Leu Trp Met Thr Ala 
            580                 585                 590         


Val Thr Ala Ala Gly Glu Ser Pro Gln Gly Asn Glu Arg Glu Phe Cys 
        595                 600                 605             


Pro Gln Gly Lys Ala Asn Trp Lys Ala Phe Val Ile Ser Ser Ile Cys 
    610                 615                 620                 


Ile Ala Ile Ile Thr Val Gly Thr Phe Ser Ile Arg Tyr Phe Arg Gln 
625                 630                 635                 640 


Lys Ala Phe Thr Leu Leu Ser Thr Leu Lys Pro Gln Trp Tyr Ser Arg 
                645                 650                 655     


Thr Ile Pro Asp Pro Ala Asn Ser Thr Trp Val Lys Lys Tyr Pro Ile 
            660                 665                 670         


Leu Glu Glu Lys Ile Gln Leu Pro Thr Asp Asn Leu Leu Met Ala Trp 
        675                 680                 685             


Pro Thr Pro Glu Glu Pro Glu Pro Leu Ile Ile His Glu Val Leu Tyr 
    690                 695                 700                 


His Met Ile Pro Val Val Arg Gln Pro Tyr Tyr Phe Lys Arg Gly Gln 
705                 710                 715                 720 


Gly Phe Gln Gly Tyr Ser Thr Ser Lys Gln Asp Ala Met Tyr Ile Ala 
                725                 730                 735     


Asn Pro Gln Ala Thr Gly Thr Leu Thr Ala Glu Thr Arg Gln Leu Val 
            740                 745                 750         


Asn Leu Tyr Lys Val Leu Glu Ser Arg Asp Pro Asp Ser Lys Leu Ala 
        755                 760                 765             


Asn Leu Thr Ser Pro Leu Thr Val Thr Pro Val Asn Tyr Leu Pro Ser 
    770                 775                 780                 


His Glu Gly Tyr Leu Pro Ser Asn Ile Glu Asp Leu Ser Pro His Glu 
785                 790                 795                 800 


Ala Asp Pro Thr Asp Ser Phe Asp Leu Glu His Gln His Ile Ser Leu 
                805                 810                 815     


Ser Ile Phe Ala Ser Ser Ser Leu Arg Pro Leu Ile Phe Gly Gly Glu 
            820                 825                 830         


Arg Leu Thr Leu Asp Arg Leu Lys Met Gly Tyr Asp Ser Leu Met Ser 
        835                 840                 845             


Asn Glu Ala 
    850     


<210>  373
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  373

Gln Leu Gly Ala Ser Gly Pro Gly Asp Gly Cys Cys Val Glu Lys Thr 
1               5                   10                  15      


Ser Phe Pro Glu Gly Ala Ser Gly Ser Pro Leu Gly Pro Arg Asn Leu 
            20                  25                  30          


Ser Cys Tyr Arg Val Ser Lys Thr Asp Tyr Glu Cys Ser Trp Gln Tyr 
        35                  40                  45              


Asp Gly Pro Glu Asp Asn Val Ser His Val Leu Trp Cys Cys Phe Val 
    50                  55                  60                  


Pro Pro Asn His Thr His Thr Gly Gln Glu Arg Cys Arg Tyr Phe Ser 
65                  70                  75                  80  


Ser Gly Pro Asp Arg Thr Val Gln Phe Trp Glu Gln Asp Gly Ile Pro 
                85                  90                  95      


Val Leu Ser Lys Val Asn Phe Trp Val Glu Ser Arg Leu Gly Asn Arg 
            100                 105                 110         


Thr Met Lys Ser Gln Lys Ile Ser Gln Tyr Leu Tyr Asn Trp Thr Lys 
        115                 120                 125             


Thr Thr Pro Pro Leu Gly His Ile Lys Val Ser Gln Ser His Arg Gln 
    130                 135                 140                 


Leu Arg Met Asp Trp Asn Val Ser Glu Glu Ala Gly Ala Glu Val Gln 
145                 150                 155                 160 


Phe Arg Arg Arg Met Pro Thr Thr Asn Trp Thr Leu Gly Asp Cys Gly 
                165                 170                 175     


Pro Gln Val Asn Ser Gly Ser Gly Val Leu Gly Asp Ile Arg Gly Ser 
            180                 185                 190         


Met Ser Glu Ser Cys Leu Cys Pro Ser Glu Asn Met Ala Gln Glu Ile 
        195                 200                 205             


Gln Ile Arg Arg Arg Arg Arg Leu Ser Ser Gly Ala Pro Gly Gly Pro 
    210                 215                 220                 


Trp Ser Asp Trp Ser Met Pro Val Cys Val Pro Pro Glu Val Leu Pro 
225                 230                 235                 240 


Gln Ala Leu Val Pro Arg Gly Ser 
                245             


<210>  374
<211>  719
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  374

Gln Leu Gly Ala Ser Gly Pro Gly Asp Gly Cys Cys Val Glu Lys Thr 
1               5                   10                  15      


Ser Phe Pro Glu Gly Ala Ser Gly Ser Pro Leu Gly Pro Arg Asn Leu 
            20                  25                  30          


Ser Cys Tyr Arg Val Ser Lys Thr Asp Tyr Glu Cys Ser Trp Gln Tyr 
        35                  40                  45              


Asp Gly Pro Glu Asp Asn Val Ser His Val Leu Trp Cys Cys Phe Val 
    50                  55                  60                  


Pro Pro Asn His Thr His Thr Gly Gln Glu Arg Cys Arg Tyr Phe Ser 
65                  70                  75                  80  


Ser Gly Pro Asp Arg Thr Val Gln Phe Trp Glu Gln Asp Gly Ile Pro 
                85                  90                  95      


Val Leu Ser Lys Val Asn Phe Trp Val Glu Ser Arg Leu Gly Asn Arg 
            100                 105                 110         


Thr Met Lys Ser Gln Lys Ile Ser Gln Tyr Leu Tyr Asn Trp Thr Lys 
        115                 120                 125             


Thr Thr Pro Pro Leu Gly His Ile Lys Val Ser Gln Ser His Arg Gln 
    130                 135                 140                 


Leu Arg Met Asp Trp Asn Val Ser Glu Glu Ala Gly Ala Glu Val Gln 
145                 150                 155                 160 


Phe Arg Arg Arg Met Pro Thr Thr Asn Trp Thr Leu Gly Asp Cys Gly 
                165                 170                 175     


Pro Gln Val Asn Ser Gly Ser Gly Val Leu Gly Asp Ile Arg Gly Ser 
            180                 185                 190         


Met Ser Glu Ser Cys Leu Cys Pro Ser Glu Asn Met Ala Gln Glu Ile 
        195                 200                 205             


Gln Ile Arg Arg Arg Arg Arg Leu Ser Ser Gly Ala Pro Gly Gly Pro 
    210                 215                 220                 


Trp Ser Asp Trp Ser Met Pro Val Cys Val Pro Pro Glu Val Leu Pro 
225                 230                 235                 240 


Gln Ala Lys Ile Lys Phe Leu Val Glu Pro Leu Asn Gln Gly Gly Arg 
                245                 250                 255     


Arg Arg Leu Thr Met Gln Gly Gln Ser Pro Gln Leu Ala Val Pro Glu 
            260                 265                 270         


Gly Cys Arg Gly Arg Pro Gly Ala Gln Val Lys Lys His Leu Val Leu 
        275                 280                 285             


Val Arg Met Leu Ser Cys Arg Cys Gln Ala Gln Thr Ser Lys Thr Val 
    290                 295                 300                 


Pro Leu Gly Lys Lys Leu Asn Leu Ser Gly Ala Thr Tyr Asp Leu Asn 
305                 310                 315                 320 


Val Leu Ala Lys Thr Arg Phe Gly Arg Ser Thr Ile Gln Lys Trp His 
                325                 330                 335     


Leu Pro Ala Gln Glu Leu Thr Glu Thr Arg Ala Leu Asn Val Ser Val 
            340                 345                 350         


Gly Gly Asn Met Thr Ser Met Gln Trp Ala Ala Gln Ala Pro Gly Thr 
        355                 360                 365             


Thr Tyr Cys Leu Glu Trp Gln Pro Trp Phe Gln His Arg Asn His Thr 
    370                 375                 380                 


His Cys Thr Leu Ile Val Pro Glu Glu Glu Asp Pro Ala Lys Met Val 
385                 390                 395                 400 


Thr His Ser Trp Ser Ser Lys Pro Thr Leu Glu Gln Glu Glu Cys Tyr 
                405                 410                 415     


Arg Ile Thr Val Phe Ala Ser Lys Asn Pro Lys Asn Pro Met Leu Trp 
            420                 425                 430         


Ala Thr Val Leu Ser Ser Tyr Tyr Phe Gly Gly Asn Ala Ser Arg Ala 
        435                 440                 445             


Gly Thr Pro Arg His Val Ser Val Arg Asn Gln Thr Gly Asp Ser Val 
    450                 455                 460                 


Ser Val Glu Trp Thr Ala Ser Gln Leu Ser Thr Cys Pro Gly Val Leu 
465                 470                 475                 480 


Thr Gln Tyr Val Val Arg Cys Glu Ala Glu Asp Gly Ala Trp Glu Ser 
                485                 490                 495     


Glu Trp Leu Val Pro Pro Thr Lys Thr Gln Val Thr Leu Asp Gly Leu 
            500                 505                 510         


Arg Ser Arg Val Met Tyr Lys Val Gln Val Arg Ala Asp Thr Ala Arg 
        515                 520                 525             


Leu Pro Gly Ala Trp Ser His Pro Gln Arg Phe Ser Phe Glu Val Gln 
    530                 535                 540                 


Ile Ser Arg Leu Ser Ile Ile Phe Ala Ser Leu Gly Ser Phe Ala Ser 
545                 550                 555                 560 


Val Leu Leu Val Gly Ser Leu Gly Tyr Ile Gly Leu Asn Arg Ala Ala 
                565                 570                 575     


Trp His Leu Cys Pro Pro Leu Pro Thr Pro Cys Gly Ser Thr Ala Val 
            580                 585                 590         


Glu Phe Pro Gly Ser Gln Gly Lys Gln Ala Trp Gln Trp Cys Asn Pro 
        595                 600                 605             


Glu Asp Phe Pro Glu Val Leu Tyr Pro Arg Asp Ala Leu Val Val Glu 
    610                 615                 620                 


Met Pro Gly Asp Arg Gly Asp Gly Thr Glu Ser Pro Gln Ala Ala Pro 
625                 630                 635                 640 


Glu Cys Ala Leu Asp Thr Arg Arg Pro Leu Glu Thr Gln Arg Gln Arg 
                645                 650                 655     


Gln Val Gln Ala Leu Ser Glu Ala Arg Arg Leu Gly Leu Ala Arg Glu 
            660                 665                 670         


Asp Cys Pro Arg Gly Asp Leu Ala His Val Thr Leu Pro Leu Leu Leu 
        675                 680                 685             


Gly Gly Val Thr Gln Gly Ala Ser Val Leu Asp Asp Leu Trp Arg Thr 
    690                 695                 700                 


His Lys Thr Ala Glu Pro Gly Pro Pro Thr Leu Gly Gln Glu Ala 
705                 710                 715                 


<210>  375
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  375

Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr 
    210                 


<210>  376
<211>  77
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  376

Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro 
65                  70                  75          


<210>  377
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  377

Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro 
65          


<210>  378
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  378

Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg 
65  


<210>  379
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  379

Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val 
65                  70                  75                  80  


Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly 
                85                  90                  95      


Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr 
            100                 105                 110         


Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro 
        115                 120                 125             


Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr 
    130                 135                 140                 


Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser 
145                 150                 155                 160 


His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr 
                165                 170                 175 


<210>  380
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  380

Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val 
65                  70                  75                  80  


Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly 
                85                  90                  95      


Lys Glu Pro Ala Ala Ser 
            100         


<210>  381
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  381

Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser 
65                  70                  75              


<210>  382
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  382

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                85                  90                  95      


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
            100                 105                 110         


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
        115                 120                 125             


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
    130                 135                 140                 


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
145                 150                 155                 160 


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
                165                 170                 175     


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
            180                 185                 190         


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
        195                 200                 205             


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
    210                 215                 220                 


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
225                 230                 235                 240 


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
                245                 250                 255     


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 
            260                 265         


<210>  383
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  383

Ala Val Lys Asn Cys Ser His Leu Glu Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Val Ser Cys Met Trp Ser His Glu Glu Ala Leu Asn Val Thr Thr 
            20                  25                  30          


Cys His Val His Ala Lys Ser Asn Leu Arg His Trp Asn Lys Thr Cys 
        35                  40                  45              


Glu Leu Thr Leu Val Arg Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ser Phe Pro Glu Ser Gln Ser Leu Thr Ser Val Asp Leu Leu Asp 
65                  70                  75                  80  


Ile Asn Val Val Cys Trp Glu Glu Lys Gly Trp Arg Arg Val Lys Thr 
                85                  90                  95      


Cys Asp Phe His Pro Phe Asp Asn Leu Arg Leu Val Ala Pro His Ser 
            100                 105                 110         


Leu Gln Val Leu His Ile Asp Thr Gln Arg Cys Asn Ile Ser Trp Lys 
        115                 120                 125             


Val Ser Gln Val Ser His Tyr Ile Glu Pro Tyr Leu Glu Phe Glu Ala 
    130                 135                 140                 


Arg Arg Arg Leu Leu Gly His Ser Trp Glu Asp Ala Ser Val Leu Ser 
145                 150                 155                 160 


Leu Lys Gln Arg Gln Gln Trp Leu Phe Leu Glu Met Leu Ile Pro Ser 
                165                 170                 175     


Thr Ser Tyr Glu Val Gln Val Arg Val Lys Ala Gln Arg Asn Asn Thr 
            180                 185                 190         


Gly Thr Trp Ser Pro Trp Ser Gln Pro Leu Thr Phe Arg Thr Arg Pro 
        195                 200                 205             


Ala Asp Pro Met Lys Glu 
    210                 


<210>  384
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  384

Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr 
    210                 


<210>  385
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  385

Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln 
            180                 185             


<210>  386
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  386

Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe 
        


<210>  387
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  387

Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp 
    210             


<210>  388
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  388

Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Ser Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Ser Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp 
    210             


<210>  389
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  389

Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Ser Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Glu Asp His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Trp Lys Gln Glu Trp Ile Ser Leu Ala Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp 
    210             


<210>  390
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  390

Cys Gly Gly His Gln Tyr Glu Arg Arg Gly Gly Cys 
1               5                   10          


<210>  391
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  391

Cys Gly Gly His Tyr Phe Glu Arg His Gly Gly Cys 
1               5                   10          


<210>  392
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  392

Cys Gln Lys Leu Thr Thr Val Asp Ile Cys 
1               5                   10  


<210>  393
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  393

Cys Ser Phe His Gln Tyr Glu Arg His Glu Gly Cys 
1               5                   10          


<210>  394
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  394

Cys Ser Gly His Gln Tyr Glu Arg Arg Glu Gly Cys 
1               5                   10          


<210>  395
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  395

Cys Ser Gly His Tyr Phe Glu Arg His Glu Gly Cys 
1               5                   10          


<210>  396
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  396

Cys Ser His Tyr Phe Glu Arg Cys 
1               5               


<210>  397
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  397

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Leu 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Ala Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg 
        


<210>  398
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  398

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Ser Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ser Trp Leu Gln Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Thr Gln Phe Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  399
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  399

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Ser Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ser Trp Leu Gln Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Thr 
                85                  90                  95      


Ser Gln Phe Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  400
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  400

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Ser Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ser Trp Leu Gln Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Thr 
                85                  90                  95      


Thr Gln Phe Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  401
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  401

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Ser Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ser Trp Leu Gln Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Val 
                85                  90                  95      


Thr Gln Phe Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  402
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  402

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 


<210>  403
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  403

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Ile Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys 
            180                 185                 190         


Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr 
        195                 200                 205             


Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
    210                 215                 


<210>  404
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  404

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Ile Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys 
            180                 185                 190         


<210>  405
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  405

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Ile Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro 
        


<210>  406
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  406

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Ile Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Val Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys 
            180                 185                 190         


Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr 
        195                 200                 205             


Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
    210                 215                 


<210>  407
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  407

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Ile Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Val Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys 
            180                 185                 190         


<210>  408
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  408

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Ile Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Val Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro 
        


<210>  409
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  409

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Glu Leu Val Tyr Met Leu Cys Thr Gly Asn 
        35                  40                  45              


Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala 
    50                  55                  60                  


Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys 
65                  70                  75                  80  


Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln 
                85                  90                  95      


Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu 
            100                 105                 110         


Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr 
        115                 120                 125             


Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser 
    130                 135                 140                 


Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu 
145                 150                 155                 160 


Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu Lys 
                165                 170                 175     


Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys Leu 
            180                 185                 190         


Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr Met 
        195                 200                 205             


Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
    210                 215             


<210>  410
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  410

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Glu Leu Val Tyr Met Leu Cys Thr Gly Asn 
        35                  40                  45              


Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala 
    50                  55                  60                  


Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys 
65                  70                  75                  80  


Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln 
                85                  90                  95      


Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu 
            100                 105                 110         


Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr 
        115                 120                 125             


Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser 
    130                 135                 140                 


Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu 
145                 150                 155                 160 


Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu Lys 
                165                 170                 175     


Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys 
            180                 185                 190     


<210>  411
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  411

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Glu Leu Val Tyr Met Leu Cys Thr Gly Asn 
        35                  40                  45              


Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala 
    50                  55                  60                  


Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys 
65                  70                  75                  80  


Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln 
                85                  90                  95      


Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu 
            100                 105                 110         


Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr 
        115                 120                 125             


Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser 
    130                 135                 140                 


Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu 
145                 150                 155                 160 


Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu Lys 
                165                 170                 175     


Pro 
    


<210>  412
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  412

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser 
    50                  55                  60              


<210>  413
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  413

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu 
                165     


<210>  414
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  414

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys 
            180                 185                 190         


Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr 
        195                 200                 205             


Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
    210                 215                 


<210>  415
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  415

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys 
            180                 185                 190         


<210>  416
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  416

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro 
        


<210>  417
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  417

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys 
            180                 185                 190         


Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr 
        195                 200                 205             


Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
    210                 215                 


<210>  418
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  418

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly 
                165 


<210>  419
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  419

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr 
                


<210>  420
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  420

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys 
            180                 185                 190         


Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr 
        195                 200                 205             


Met Glu Thr Ser 
    210         


<210>  421
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  421

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Ser Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Ser Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu 
                165     


<210>  422
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  422

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Val Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys 
            180                 185                 190         


Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr 
        195                 200                 205             


Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
    210                 215                 


<210>  423
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  423

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Val Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys 
            180                 185                 190         


<210>  424
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  424

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Val Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro 
        


<210>  425
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  425

Glu Leu Cys Leu Tyr Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Ile Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys 
            180                 185                 190         


Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr 
        195                 200                 205             


Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
    210                 215                 


<210>  426
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  426

Glu Leu Cys Leu Tyr Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Ile Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys 
            180                 185                 190         


<210>  427
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  427

Glu Leu Cys Leu Tyr Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Ile Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Val Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys 
            180                 185                 190         


Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr 
        195                 200                 205             


Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
    210                 215                 


<210>  428
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  428

Glu Leu Cys Leu Tyr Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Ile Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Val Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys 
            180                 185                 190         


<210>  429
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  429

Glu Leu Cys Leu Tyr Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Ile Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Val Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro 
        


<210>  430
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  430

Glu Leu Cys Leu Tyr Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys 
            180                 185                 190         


Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr 
        195                 200                 205             


Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
    210                 215                 


<210>  431
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  431

Glu Leu Cys Leu Tyr Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys 
            180                 185                 190         


<210>  432
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  432

Glu Leu Cys Leu Tyr Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro 
        


<210>  433
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  433

Glu Leu Cys Leu Tyr Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Val Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys 
            180                 185                 190         


Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr 
        195                 200                 205             


Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
    210                 215                 


<210>  434
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  434

Glu Leu Cys Leu Tyr Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Val Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys 
            180                 185                 190         


<210>  435
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2

<400>  435

Glu Leu Cys Leu Tyr Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Val Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro 
        


<210>  436
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  436

Glu Leu Cys Leu Tyr Asp Pro Pro Glu Val Pro Asn Ala Thr Phe Lys 
1               5                   10                  15      


Ala Leu Ser Tyr Lys Asn Gly Thr Ile Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Leu Lys Glu Leu Val Tyr Met Arg Cys Leu Gly Asn 
        35                  40                  45              


Ser Trp Ser Ser Asn Cys Gln Cys Thr Ser 
    50                  55              


<210>  437
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  437

Glu Leu Cys Leu Tyr Asp Pro Pro Glu Val Pro Asn Ala Thr Phe Lys 
1               5                   10                  15      


Ala Leu Ser Tyr Lys Asn Gly Thr Ile Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Leu Lys Glu Leu Val Tyr Met Arg Cys Leu Gly Asn 
        35                  40                  45              


Ser Trp Ser Ser Asn Cys Gln Cys Thr Ser Asn Ser His Asp Lys Ser 
    50                  55                  60                  


Arg Lys Gln Val Thr Ala Gln Leu Glu His Gln Lys Glu Gln Gln Thr 
65                  70                  75                  80  


Thr Thr Asp Met Gln Lys Pro Thr Gln Ser Met His Gln Glu Asn Leu 
                85                  90                  95      


Thr Gly His Cys Arg Glu Pro Pro Pro Trp Lys His Glu Asp Ser Lys 
            100                 105                 110         


Arg Ile Tyr His Phe Val Glu Gly Gln Ser Val His Tyr Glu Cys Ile 
        115                 120                 125             


Pro Gly Tyr Lys Ala Leu Gln Arg Gly Pro Ala Ile Ser Ile Cys Lys 
    130                 135                 140                 


Met Lys Cys Gly Lys Thr Gly Trp Thr Gln Pro Gln Leu Thr Cys Val 
145                 150                 155                 160 


Asp Glu Arg Glu His His Arg Phe Leu Ala Ser Glu Glu Ser Gln Gly 
                165                 170                 175     


Ser Arg Asn Ser Ser Pro Glu Ser Glu Thr Ser Cys Pro Ile Thr Thr 
            180                 185                 190         


Thr Asp Phe Pro Gln Pro Thr Glu Thr Thr Ala Met Thr Glu Thr Phe 
        195                 200                 205             


Val Leu Thr Met Glu Tyr Lys 
    210                 215 


<210>  438
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  438

Glu Leu Cys Leu Tyr Asp Pro Pro Glu Val Pro Asn Ala Thr Phe Lys 
1               5                   10                  15      


Ala Leu Ser Tyr Lys Asn Gly Thr Ile Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Leu Lys Glu Leu Val Tyr Met Arg Cys Leu Gly Asn 
        35                  40                  45              


Ser Trp Ser Ser Asn Cys Gln Cys Thr Ser Asn Ser His Asp Lys Ser 
    50                  55                  60                  


Arg Lys Gln Val Thr Ala Gln Leu Glu His Gln Lys Glu Gln Gln Thr 
65                  70                  75                  80  


Thr Thr Asp Met Gln Lys Pro Thr Gln Ser Met His Gln Glu Asn Leu 
                85                  90                  95      


Thr Gly His Cys Arg Glu Pro Pro Pro Trp Lys His Glu Asp Ser Lys 
            100                 105                 110         


Arg Ile Tyr His Phe Val Glu Gly Gln Ser Val His Tyr Glu Cys Ile 
        115                 120                 125             


Pro Gly Tyr Lys Ala Leu Gln Arg Gly Pro Ala Ile Ser Ile Cys Lys 
    130                 135                 140                 


Met Lys Cys Gly Lys Thr Gly Trp Thr Gln Pro Gln Leu Thr Cys Val 
145                 150                 155                 160 


Asp Glu Arg Glu His His Arg Phe Leu Ala Ser Glu Glu Ser Gln Gly 
                165                 170                 175     


Ser Arg Asn Ser Ser Pro Glu Ser Glu Thr Ser Cys Pro Ile Thr Thr 
            180                 185                 190         


Thr Asp Phe Pro Gln Pro Thr Glu Thr Thr Ala Met Thr Glu Thr Phe 
        195                 200                 205             


Val Leu Thr Met Glu Tyr Lys 
    210                 215 


<210>  439
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  439

Glu Leu Cys Leu Tyr Asp Pro Pro Glu Val Pro Asn Ala Thr Phe Lys 
1               5                   10                  15      


Ala Leu Ser Tyr Lys Asn Gly Thr Ile Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Leu Lys Glu Leu Val Tyr Met Arg Cys Leu Gly Asn 
        35                  40                  45              


Ser Trp Ser Ser Asn Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr 
    50                  55                  60                  


Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr 
65                  70                  75                  80  


Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro 
                85                  90                  95      


Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg 
            100                 105                 110         


Ile Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln 
        115                 120                 125             


Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met 
    130                 135                 140                 


Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly 
145                 150                 155                 160 


Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu Lys Pro Gln Ala Ser 
                165                 170                 175     


Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys Leu Val Thr Thr Thr 
            180                 185                 190         


Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr Met Glu Thr Ser Ile 
        195                 200                 205             


Phe Thr Thr Glu Tyr Gln 
    210                 


<210>  440
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  440

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gln Val Ala Gly Met Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  441
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  441

Gly Met Leu Ser Leu Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe 
1               5                   10                  15      


Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala 
            20                  25                  30          


Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg 
        35                  40                  45              


Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala 
    50                  55                  60                  


Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val 
65                  70                  75                  80  


Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg 
                85                  90                  95      


Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met 
            100                 105                 110         


Ala Pro Ile Ser Leu Gln Val Val His Val Glu Thr His Arg Cys Asn 
        115                 120                 125             


Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu 
    130                 135                 140                 


Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala 
145                 150                 155                 160 


Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr 
                165                 170                 175     


Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu 
            180                 185                 190         


Gln Ala Phe Arg Thr Leu Thr Gly His 
        195                 200     


<210>  442
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  442

Gly Met Leu Ser Leu Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
1               5                   10                  15      


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
            20                  25                  30          


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
        35                  40                  45              


Met Leu Cys Thr Gly Ser Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
    50                  55                  60                  


Gln Cys Thr Ser Ser Ala Thr Arg Ser Thr Thr Lys Gln Val Thr Pro 
65                  70                  75                  80  


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
                85                  90                  95      


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
            100                 105                 110         


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
        115                 120                 125             


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
    130                 135                 140                 


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
145                 150                 155                 160 


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
                165                 170     


<210>  443
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  443

Gly Met Leu Ser Leu Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
1               5                   10                  15      


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
            20                  25                  30          


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
        35                  40                  45              


Met Leu Cys Thr Gly Ser Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
    50                  55                  60                  


Gln Cys Thr Ser Ser Ala Thr Arg Ser Thr Thr Lys Gln Val Thr Pro 
65                  70                  75                  80  


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
                85                  90                  95      


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
            100                 105                 110         


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
        115                 120                 125             


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
    130                 135                 140                 


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
145                 150                 155                 160 


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Ala Ser 
                165                 170             


<210>  444
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  444

Gly Met Leu Ser Leu Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
1               5                   10                  15      


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
            20                  25                  30          


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
        35                  40                  45              


Met Leu Cys Thr Gly Ser Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
    50                  55                  60                  


Gln Cys Thr Ser Ser Ala Thr Arg Ser Thr Thr Lys Gln Val Thr Pro 
65                  70                  75                  80  


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
                85                  90                  95      


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
            100                 105                 110         


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
        115                 120                 125             


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
    130                 135                 140                 


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
145                 150                 155                 160 


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Ala Ser Gly Gly Gly 
                165                 170                 175     


Gly His His His His His His 
            180             


<210>  445
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  445

Gly Met Leu Ser Leu Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
1               5                   10                  15      


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
            20                  25                  30          


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
        35                  40                  45              


Met Leu Cys Thr Gly Ser Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
    50                  55                  60                  


Gln Cys Thr Ser Ser Ala Thr Arg Ser Thr Thr Lys Gln Val Thr Pro 
65                  70                  75                  80  


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
                85                  90                  95      


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
            100                 105                 110         


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
        115                 120                 125             


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
    130                 135                 140                 


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
145                 150                 155                 160 


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Ala Ser 
                165                 170             


<210>  446
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  446

Gly Met Leu Ser Leu Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
1               5                   10                  15      


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
            20                  25                  30          


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
        35                  40                  45              


Met Leu Cys Thr Gly Ser Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
    50                  55                  60                  


Gln Cys Thr Ser Ser Ala Thr Arg Ser Thr Thr Lys Gln Val Thr Pro 
65                  70                  75                  80  


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
                85                  90                  95      


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
            100                 105                 110         


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
        115                 120                 125             


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
    130                 135                 140                 


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
145                 150                 155                 160 


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Ala Ser Gly Gly Gly 
                165                 170                 175     


Gly His His His His His His 
            180             


<210>  447
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  447

Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly Asn Glu Asp Thr Thr Ala 
1               5                   10                  15      


Asp Phe Phe Leu Thr Thr Met Pro Thr Asp Ser Leu Ser Val Ser Thr 
            20                  25                  30          


Leu Pro Leu Pro Glu Val Gln Cys Phe Val Phe Asn Val Glu Tyr Met 
        35                  40                  45              


Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro Gln Pro Thr Asn Leu Thr 
    50                  55                  60                  


Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn Asp Lys Val Gln Lys Cys 
65                  70                  75                  80  


Ser His Tyr Leu Phe Ser Glu Glu Ile Thr Ser Gly Cys Gln Leu Gln 
                85                  90                  95      


Lys Lys Glu Ile His Leu Tyr Gln Thr Phe Val Val Gln Leu Gln Asp 
            100                 105                 110         


Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln Met Leu Lys Leu Gln Asn 
        115                 120                 125             


Leu Val Ile Pro Trp Ala Pro Glu Asn Leu Thr Leu His Lys Leu Ser 
    130                 135                 140                 


Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn Arg Phe Leu Asn His Cys 
145                 150                 155                 160 


Leu Glu His Leu Val Gln Tyr Arg Thr Asp Trp Asp His Ser Trp Thr 
                165                 170                 175     


Glu Gln Ser Val Asp Tyr Arg His Lys Phe Ser Leu Pro Ser Val Asp 
            180                 185                 190         


Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg Ser Arg Phe Asn Pro Leu 
        195                 200                 205             


Cys Gly Ser Ala Gln His Trp Ser Glu Trp Ser His Pro Ile His Trp 
    210                 215                 220                 


Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe Leu Phe Ala Leu Glu Ala 
225                 230                 235                 240 


Val 
    


<210>  448
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  448

Met Asp Ser Tyr Leu Leu Met Trp Gly Leu Leu Thr Phe Ile Met Val 
1               5                   10                  15      


Pro Gly Cys Gln Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
            20                  25                  30          


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
        35                  40                  45              


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
    50                  55                  60                  


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
65                  70                  75                  80  


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
                85                  90                  95      


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
            100                 105                 110         


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
        115                 120                 125             


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
    130                 135                 140                 


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
145                 150                 155                 160 


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
                165                 170                 175     


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln 
            180                 185                 190         


Phe Pro Gly Glu Glu Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu 
        195                 200                 205             


Ser Glu Thr Ser Cys Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr 
    210                 215                 220                 


Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
225                 230                 235                 240 


Val Ala Val Ala Gly Cys Val Phe Leu Leu Ile Ser Val Leu Leu Leu 
                245                 250                 255     


Ser Gly Leu Thr Trp Gln Arg Arg Gln Arg Lys Ser Arg Arg Thr Ile 
            260                 265                 270         


<210>  449
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  449

Met Leu Ser Leu Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His 
1               5                   10                  15      


Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys 
            20                  25                  30          


Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met 
        35                  40                  45              


Leu Cys Thr Gly Ser Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln 
    50                  55                  60                  


Cys Thr Ser Ser Ala Thr Arg Ser Thr Thr Lys Gln Val Thr Pro Gln 
65                  70                  75                  80  


Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met 
                85                  90                  95      


Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro 
            100                 105                 110         


Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly 
        115                 120                 125             


Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg 
    130                 135                 140                 


Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp 
145                 150                 155                 160 


Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
                165                 170 


<210>  450
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  450

Gln Lys Leu Thr Thr Val Asp Ile 
1               5               


<210>  451
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  451

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Val Ile Trp Tyr Asp Gly Ser Asn Glu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Trp Leu Gly Glu Ala Asp Tyr Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  452
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  452

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Val Ile Trp Tyr Asp Gly Ser Asn Glu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Glu Gln Trp Arg Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  453
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  453

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Val Ile Trp Tyr Asp Gly Ser Asn Glu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Glu Gln Trp Arg Leu Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  454
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  454

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Val Ile Trp Tyr Asp Gly Ser Asn Glu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Val Ala Gly Thr Gly Arg Asp Tyr Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  455
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  455

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Val Ile Trp Tyr Asp Gly Ser Asn Glu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Ser Ser Gly Tyr Tyr Tyr Gly Glu Asp 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  456
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  456

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Val Ile Trp Tyr Asp Gly Ser Asn Glu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Glu Trp Glu Leu Glu Asp Tyr Gly Met Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  457
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  457

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Val Ile Trp Tyr Asp Gly Ser Asn Glu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asn Trp Gly Ser Asp Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  458
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  458

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Val Ile Trp Tyr Asp Gly Ser Asn Glu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asp Trp Phe Gly Glu Ala Asp Tyr Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  459
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  459

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Val Ile Trp Tyr Asp Gly Ser Asn Glu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ile Ser Ile Thr Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  460
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  460

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Val Ile Trp Tyr Asp Gly Ser Asn Glu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asp Phe Trp Ser Asp Tyr Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  461
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  461

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Val Ile Trp Tyr Asp Gly Ser Asn Glu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Glu Trp Phe Gly Glu Ala Asp Tyr Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  462
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  462

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Val Ile Trp Tyr Asp Gly Ser Asn Glu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Ser Ser Gly Tyr Tyr Phe Gly Glu Asp 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  463
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  463

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Val Ile Trp Tyr Asp Gly Ser Asn Glu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Val Ala Gly Thr Gly Arg Asp Tyr Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  464
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  464

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Phe Asp Ser His Tyr Gly Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  465
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  465

Ser His Tyr Phe Glu Arg 
1               5       


<210>  466
<211>  197
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  466

Thr Leu Pro Leu Pro Glu Val Gln Cys Phe Val Phe Asn Val Glu Tyr 
1               5                   10                  15      


Met Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro Gln Pro Thr Asn Leu 
            20                  25                  30          


Thr Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn Asp Lys Val Gln Lys 
        35                  40                  45              


Cys Ser His Tyr Leu Phe Ser Glu Glu Ile Thr Ser Gly Cys Gln Leu 
    50                  55                  60                  


Gln Lys Lys Glu Ile His Leu Tyr Gln Thr Phe Val Val Gln Leu Gln 
65                  70                  75                  80  


Asp Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln Met Leu Lys Leu Gln 
                85                  90                  95      


Asn Leu Val Ile Pro Trp Ala Pro Glu Asn Leu Thr Leu His Lys Leu 
            100                 105                 110         


Ser Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn Arg Phe Leu Asn His 
        115                 120                 125             


Cys Leu Glu His Leu Val Gln Tyr Arg Thr Asp Trp Asp His Ser Trp 
    130                 135                 140                 


Thr Glu Gln Ser Val Asp Tyr Arg His Lys Phe Ser Leu Pro Ser Val 
145                 150                 155                 160 


Asp Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg Ser Arg Phe Asn Pro 
                165                 170                 175     


Leu Cys Gly Ser Ala Gln His Trp Ser Glu Trp Ser His Pro Ile His 
            180                 185                 190         


Trp Gly Ser Asn Thr 
        195         


<210>  467
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  467

Thr Leu Pro Leu Pro Glu Val Gln Cys Phe Val Phe Asn Val Glu Tyr 
1               5                   10                  15      


Met Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro Gln Pro Thr Asn Leu 
            20                  25                  30          


Thr Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn Asp Lys Val Gln Lys 
        35                  40                  45              


Cys Ser His Tyr Leu Phe Ser Glu Glu Ile Thr Ser Gly Cys Gln Leu 
    50                  55                  60                  


Gln Lys Lys Glu Ile His Leu Tyr Gln Thr Phe Val Val Gln Leu Gln 
65                  70                  75                  80  


Asp Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln Met Leu Lys Leu Gln 
                85                  90                  95      


Asn Leu Val Ile 
            100 


<210>  468
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  468

Trp Ser Ser Lys Val Leu Met Ser Ser Ala Asn Glu Asp Ile Lys Ala 
1               5                   10                  15      


Asp Leu Ile Leu Thr Ser Thr Ala Pro Glu His Leu Ser Ala Pro Thr 
            20                  25                  30          


Leu Pro Leu Pro Glu Val Gln Cys Phe Val Phe Asn Ile Glu Tyr Met 
        35                  40                  45              


Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro Gln Ala Thr Asn Leu Thr 
    50                  55                  60                  


Leu His Tyr Arg Tyr Lys Val Ser Asp Asn Asn Thr Phe Gln Glu Cys 
65                  70                  75                  80  


Ser His Tyr Leu Phe Ser Lys Glu Ile Thr Ser Gly Cys Gln Ile Gln 
                85                  90                  95      


Lys Glu Asp Ile Gln Leu Tyr Gln Thr Phe Val Val Gln Leu Gln Asp 
            100                 105                 110         


Pro Gln Lys Pro Gln Arg Arg Ala Val Gln Lys Leu Asn Leu Gln Asn 
        115                 120                 125             


Leu Val Ile Pro Arg Ala Pro Glu Asn Leu Thr Leu Ser Asn Leu Ser 
    130                 135                 140                 


Glu Ser Gln Leu Glu Leu Arg Trp Lys Ser Arg His Ile Lys Glu Arg 
145                 150                 155                 160 


Cys Leu Gln Tyr Leu Val Gln Tyr Arg Ser Asn Arg Asp Arg Ser Trp 
                165                 170                 175     


Thr Glu Leu Ile Val Asn His Glu Pro Arg Phe Ser Leu Pro Ser Val 
            180                 185                 190         


Asp Glu Leu Lys Arg Tyr Thr Phe Arg Val Arg Ser Arg Tyr Asn Pro 
        195                 200                 205             


Ile Cys Gly Ser Ser Gln Gln Trp Ser Lys Trp Ser Gln Pro Val His 
    210                 215                 220                 


Trp Gly Ser His Thr Val Glu Glu Asn Pro Ser Leu Phe Ala Leu Glu 
225                 230                 235                 240 


Ala 
    


<210>  469
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  469

Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Gly Ser Ile Ser Ser Gly Leu Leu Ser Ser Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Ser Leu Ser Gly Arg Ser Asp Asn His Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly Asn 
            260                 265                 270         


Glu Asp Thr Thr Ala Asp Phe Phe Leu Thr Thr Met Pro Thr Asp Ser 
        275                 280                 285             


Leu Ser Val Ser Thr Leu Pro Leu Pro Glu Val Gln Cys Phe Val Phe 
    290                 295                 300                 


Asn Val Glu Tyr Met Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro Gln 
305                 310                 315                 320 


Pro Thr Asn Leu Thr Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn Asp 
                325                 330                 335     


Lys Val Lys Cys Ser His Tyr Leu Phe Ser Glu Glu Ile Thr Ser Gly 
            340                 345                 350         


Cys Gln Leu Gln Lys Lys Glu Ile His Leu Tyr Gln Thr Phe Val Val 
        355                 360                 365             


Gln Leu Gln Asp Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln Met Leu 
    370                 375                 380                 


Lys Leu Gln Asn Leu Val Ile Pro Trp Ala Pro Glu Asn Leu Thr Leu 
385                 390                 395                 400 


His Lys Leu Ser Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn Arg Phe 
                405                 410                 415     


Leu Asn His Cys Leu Glu His Leu Val Gln Tyr Arg Thr Asp Trp Asp 
            420                 425                 430         


His Ser Trp Thr Glu Gln Ser Val Asp Tyr Arg His Lys Phe Ser Leu 
        435                 440                 445             


Pro Ser Val Asp Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg Ser Arg 
    450                 455                 460                 


Phe Asn Pro Leu Cys Gly Ser Ala Gln His Trp Ser Glu Trp Ser His 
465                 470                 475                 480 


Pro Ile His Trp Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe Leu Phe 
                485                 490                 495     


Ala Leu Glu Ala 
            500 


<210>  470
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  470

Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Gly Ser Ile Ser Ser Gly Leu Leu Ser Ser Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Ser Leu Ser Gly Arg Ser Asp Asn His Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe 
            260                 265                 270         


Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala 
        275                 280                 285             


Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg 
    290                 295                 300                 


Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala 
305                 310                 315                 320 


Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val 
                325                 330                 335     


Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg 
            340                 345                 350         


Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met 
        355                 360                 365             


Ala Pro Ile Ser Leu Gln Val Val His Val Glu Thr His Arg Cys Asn 
    370                 375                 380                 


Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu 
385                 390                 395                 400 


Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala 
                405                 410                 415     


Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr 
            420                 425                 430         


Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu 
        435                 440                 445             


Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe 
    450                 455                 460                 


Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Thr 
465                 470                 475 


<210>  471
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  471

Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Glu Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr 
    210                 


<210>  472
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  472

Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp His Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr 
    210                 


<210>  473
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  473

Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Gln Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr 
    210                 


<210>  474
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  474

Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Phe Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr 
    210                 


<210>  475
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  475

Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Gln Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr 
    210                 


<210>  476
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  476

Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Gln Arg Arg Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr 
    210                 


<210>  477
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  477

Ala Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Tyr Ala 
1               5                   10                  15      


Asn Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser 
            20                  25                  30          


Cys Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys 
        35                  40                  45              


Glu Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu 
    50                  55                  60                  


Gly Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu 
65                  70                  75                  80  


Arg Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln 
                85                  90                  95      


Asp Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu 
            100                 105                 110         


Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile 
        115                 120                 125             


Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg 
    130                 135                 140                 


Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr 
                165                 170                 175     


Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr 
            180                 185                 190         


Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala 
        195                 200                 205             


Ala Leu Gly Lys Asp Thr 
    210                 


<210>  478
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  478

Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly Asn Glu Asp Thr Thr Ala 
1               5                   10                  15      


Asp Phe Phe Leu Thr Thr Met Pro Thr Asp Ser Leu Ser Val Ser Thr 
            20                  25                  30          


Leu Pro Leu Pro Glu Val Gln Cys Phe Val Phe Asn Val Glu Tyr Met 
        35                  40                  45              


Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro Gln Pro Thr Asn Leu Thr 
    50                  55                  60                  


Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn Asp Lys Val Gln Lys Cys 
65                  70                  75                  80  


Ser His Tyr Leu Phe Ser Glu Glu Ile Thr Ser Gly Cys Gln Leu Gln 
                85                  90                  95      


Lys Lys Glu Ile His Leu Tyr Gln Thr Phe Val Val Gln Leu Gln Asp 
            100                 105                 110         


Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln Met Leu Lys Leu Gln Asn 
        115                 120                 125             


Leu Val Ile Pro Trp Ala Pro Glu Asn Leu Thr Leu His Lys Leu Ser 
    130                 135                 140                 


Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn Arg Phe Leu Asn His Cys 
145                 150                 155                 160 


Leu Glu His Leu Val Gln Tyr Arg Thr Asp Trp Asp His Ser Trp Thr 
                165                 170                 175     


Glu Gln Ser Val Asp Tyr Arg His Lys Phe Ser Leu Pro Ser Val Asp 
            180                 185                 190         


Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg Ser Arg Phe Asn Pro Leu 
        195                 200                 205             


Cys Gly Ser Ala Gln His Trp Ser Glu Trp Ser His Pro Ile His Trp 
    210                 215                 220                 


Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe Leu Phe Ala Leu Glu Ala 
225                 230                 235                 240 


<210>  479
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide mask

<400>  479

Cys Pro Asp Leu Val Cys Tyr Thr Asp Tyr Leu Gln Thr Val Ile Cys 
1               5                   10                  15      


Ile Leu Glu Met Trp Asn Leu His Pro Ser Thr Leu Thr Leu Thr Trp 
            20                  25                  30          


Gln Asp Gln Tyr Glu Glu Leu Lys Asp Glu Ala Thr Ser Cys Ser Leu 
        35                  40                  45              


His Arg Ser Ala His Asn Ala Thr His Ala Thr Tyr Thr Cys His Met 
    50                  55                  60                  


Asp Val Phe His Phe Met Ala Asp Asp Ile Phe Ser Val Asn Ile Thr 
65                  70                  75                  80  


Asp Gln Ser Gly Asn Tyr Ser Gln Glu Cys Gly Ser Phe Leu Leu Ala 
                85                  90                  95      


Glu Ser Ile Lys Pro Ala Pro Pro Phe Asn Val Thr Val Thr Phe Ser 
            100                 105                 110         


Gly Gln Tyr Asn Ile Ser Trp Arg Ser Asp Tyr Glu Asp Pro Ala Phe 
        115                 120                 125             


Tyr Met Leu Lys Gly Lys Leu Gln Tyr Glu Leu Gln Tyr Arg Asn Arg 
    130                 135                 140                 


Gly Asp Pro Trp Ala Val Ser Pro Arg Arg Lys Leu Ile Ser Val Asp 
145                 150                 155                 160 


Ser Arg Ser Val Ser Leu Leu Pro Leu Glu Phe Arg Lys Asp Ser Ser 
                165                 170                 175     


Tyr Glu Leu Gln Val Arg Ala Gly Pro Met Pro Gly Ser Ser Tyr Gln 
            180                 185                 190         


Gly Thr Trp Ser Glu Trp Ser Asp Pro Val Ile Phe Gln Thr Gln Ser 
        195                 200                 205             


Glu Glu Leu Lys Glu 
    210             


<210>  480
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProC859

<400>  480

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Lys Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Asn Leu Phe Thr Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Asp Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Cys Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Met Gln Glu Glu Arg Val Gly Glu Thr Pro Leu Met Asn 
            100                 105                 110         


Val Asp Ser Ile Leu Ala Val Lys Lys Tyr Phe Arg Arg Ile Thr Leu 
        115                 120                 125             


Tyr Leu Thr Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Ile Met Arg Ser Leu Ser Leu Ser Thr Asn Leu Gln Glu Arg 
145                 150                 155                 160 


Leu Arg Arg Lys Glu Leu Ser Gly Arg Ser Asp Asn Ile Cys Pro Pro 
                165                 170                 175     


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            180                 185                 190         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        195                 200                 205             


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
    210                 215                 220                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
225                 230                 235                 240 


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                245                 250                 255     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            260                 265                 270         


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        275                 280                 285             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
    290                 295                 300                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
305                 310                 315                 320 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                325                 330                 335     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            340                 345                 350         


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        355                 360                 365             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    370                 375                 380                 


Thr Gln Lys Ser Leu Ser Leu Ser 
385                 390         


<210>  481
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Universal IFN-alpha A/D

<400>  481

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Lys Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Asn Leu Phe Thr Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Asp Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Cys Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Met Gln Glu Glu Arg Val Gly Glu Thr Pro Leu Met Asn 
            100                 105                 110         


Val Asp Ser Ile Leu Ala Val Lys Lys Tyr Phe Arg Arg Ile Thr Leu 
        115                 120                 125             


Tyr Leu Thr Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Ile Met Arg Ser Leu Ser Leu Ser Thr Asn Leu Gln Glu Arg 
145                 150                 155                 160 


Leu Arg Arg Lys Glu 
                165 


<210>  482
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  482

Met Ser Tyr Asn Leu Leu Gly Phe Leu Gln Arg Ser Ser Asn Phe Gln 
1               5                   10                  15      


Cys Gln Lys Leu Leu Trp Gln Leu Asn Gly Arg Leu Glu Tyr Cys Leu 
            20                  25                  30          


Lys Asp Arg Met Asn Phe Asp Ile Pro Glu Glu Ile Lys Gln Leu Gln 
        35                  40                  45              


Gln Phe Gln Lys Glu Asp Ala Ala Leu Thr Ile Tyr Glu Met Leu Gln 
    50                  55                  60                  


Asn Ile Phe Ala Ile Phe Arg Gln Asp Ser Ser Ser Thr Gly Trp Asn 
65                  70                  75                  80  


Glu Thr Ile Val Glu Asn Leu Leu Ala Asn Val Tyr His Gln Ile Asn 
                85                  90                  95      


His Leu Lys Thr Val Leu Glu Glu Lys Leu Glu Lys Glu Asp Phe Thr 
            100                 105                 110         


Arg Gly Lys Leu Met Ser Ser Leu His Leu Lys Arg Tyr Tyr Gly Arg 
        115                 120                 125             


Ile Leu His Tyr Leu Lys Ala Lys Glu Tyr Ser His Cys Ala Trp Thr 
    130                 135                 140                 


Ile Val Arg Val Glu Ile Leu Arg Asn Phe Tyr Phe Ile Asn Arg Leu 
145                 150                 155                 160 


Thr Gly Tyr Leu Arg Asn 
                165     


<210>  483
<211>  203
<212>  PRT
<213>  Gallus gallus

<400>  483

Met Thr Ala Asn His Gln Ser Pro Gly Met His Ser Ile Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Pro Ala Leu Thr Thr Thr Phe Ser Cys Asn His Leu Arg 
            20                  25                  30          


His Gln Asp Ala Asn Phe Ser Trp Lys Ser Leu Gln Leu Leu Gln Asn 
        35                  40                  45              


Thr Ala Pro Pro Pro Pro Gln Pro Cys Pro Gln Gln Asp Val Thr Phe 
    50                  55                  60                  


Pro Phe Pro Glu Thr Leu Leu Lys Ser Lys Asp Lys Lys Gln Ala Ala 
65                  70                  75                  80  


Ile Thr Thr Leu Arg Ile Leu Gln His Leu Phe Asn Met Leu Ser Ser 
                85                  90                  95      


Pro His Thr Pro Lys His Trp Ile Asp Arg Thr Arg His Ser Leu Leu 
            100                 105                 110         


Asn Gln Ile Gln His Tyr Ile His His Leu Glu Gln Cys Phe Val Asn 
        115                 120                 125             


Gln Gly Thr Arg Ser Gln Arg Arg Gly Pro Arg Asn Ala His Leu Ser 
    130                 135                 140                 


Ile Asn Lys Tyr Phe Arg Ser Ile His Asn Phe Leu Gln His Asn Asn 
145                 150                 155                 160 


Tyr Ser Ala Cys Thr Trp Asp His Val Arg Leu Gln Ala Arg Asp Cys 
                165                 170                 175     


Phe Arg His Val Asp Thr Leu Ile Gln Trp Met Lys Ser Arg Ala Pro 
            180                 185                 190         


Leu Thr Ala Ser Ser Lys Arg Leu Asn Thr Gln 
        195                 200             


<210>  484
<211>  187
<212>  PRT
<213>  Canis familiaris

<400>  484

Met Ala Leu Pro Cys Ser Phe Ser Val Ala Leu Val Leu Leu Ser Cys 
1               5                   10                  15      


His Ser Leu Cys Cys Leu Ala Cys His Leu Pro Asp Thr His Ser Leu 
            20                  25                  30          


Arg Asn Trp Arg Val Leu Thr Leu Leu Gly Gln Met Arg Arg Leu Ser 
        35                  40                  45              


Ala Ser Ser Cys Asp His Tyr Thr Thr Asp Phe Ala Phe Pro Lys Glu 
    50                  55                  60                  


Leu Phe Asp Gly Gln Arg Leu Gln Glu Ala Gln Ala Leu Ser Val Val 
65                  70                  75                  80  


His Val Met Thr Gln Lys Val Phe His Leu Phe Cys Thr Asn Thr Ser 
                85                  90                  95      


Ser Ala Pro Trp Asn Met Thr Leu Leu Glu Glu Leu Cys Ser Gly Leu 
            100                 105                 110         


Ser Glu Gln Leu Asp Asp Leu Asp Ala Cys Pro Leu Gln Glu Ala Gly 
        115                 120                 125             


Leu Ala Glu Thr Pro Leu Met His Glu Asp Ser Thr Leu Arg Thr Tyr 
    130                 135                 140                 


Phe Gln Arg Ile Ser Leu Tyr Leu Gln Asp Arg Asn His Ser Pro Cys 
145                 150                 155                 160 


Ala Trp Glu Met Val Arg Ala Glu Ile Gly Arg Ser Phe Phe Ser Leu 
                165                 170                 175     


Thr Ile Leu Gln Glu Arg Val Arg Arg Arg Lys 
            180                 185         


<210>  485
<211>  191
<212>  PRT
<213>  Anas platyrhynchos

<400>  485

Met Pro Gly Pro Ser Ala Pro Pro Pro Pro Ala Ile Tyr Ser Ala Leu 
1               5                   10                  15      


Ala Leu Leu Leu Leu Leu Thr Pro Pro Ala Asn Ala Phe Ser Cys Ser 
            20                  25                  30          


Pro Leu Arg Leu His Asp Ser Ala Phe Ala Trp Asp Ser Leu Gln Leu 
        35                  40                  45              


Leu Arg Asn Met Ala Pro Ser Pro Thr Gln Pro Cys Pro Gln Gln His 
    50                  55                  60                  


Ala Pro Cys Ser Phe Pro Asp Thr Leu Leu Asp Thr Asn Asp Thr Gln 
65                  70                  75                  80  


Gln Ala Ala His Thr Ala Leu His Leu Leu Gln His Leu Phe Asp Thr 
                85                  90                  95      


Leu Ser Ser Pro Ser Thr Pro Ala His Trp Leu His Thr Ala Arg His 
            100                 105                 110         


Asp Leu Leu Asn Gln Leu Gln His His Ile His His Leu Glu Arg Cys 
        115                 120                 125             


Phe Pro Ala Asp Ala Ala Arg Leu His Arg Arg Gly Pro Arg Asn Leu 
    130                 135                 140                 


His Leu Ser Ile Asn Lys Tyr Phe Gly Cys Ile Gln His Phe Leu Gln 
145                 150                 155                 160 


Asn His Thr Tyr Ser Pro Cys Ala Trp Asp His Val Arg Leu Glu Ala 
                165                 170                 175     


His Ala Cys Phe Gln Arg Ile His Arg Leu Thr Arg Thr Met Arg 
            180                 185                 190     


<210>  486
<211>  189
<212>  PRT
<213>  Bos taurus

<400>  486

Met Ala Pro Ala Trp Ser Phe Leu Leu Ala Leu Leu Leu Leu Ser Cys 
1               5                   10                  15      


Asn Ala Ile Cys Ser Leu Gly Cys His Leu Pro His Thr His Ser Leu 
            20                  25                  30          


Pro Asn Arg Arg Val Leu Thr Leu Leu Arg Gln Leu Arg Arg Val Ser 
        35                  40                  45              


Pro Ser Ser Cys Leu Gln Asp Arg Asn Asp Phe Ala Phe Pro Gln Glu 
    50                  55                  60                  


Ala Leu Gly Gly Ser Gln Leu Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Val Thr Gln His Thr Phe Gln Leu Phe Ser Thr Glu Gly Ser 
                85                  90                  95      


Ala Ala Ala Trp Asp Glu Ser Leu Leu Asp Lys Leu Arg Ala Ala Leu 
            100                 105                 110         


Asp Gln Gln Leu Thr Asp Leu Gln Ala Cys Leu Arg Gln Glu Glu Gly 
        115                 120                 125             


Leu Arg Gly Ala Pro Leu Leu Lys Glu Asp Ala Ser Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe His Arg Leu Thr Leu Tyr Leu Arg Glu Lys Arg His Asn 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Val Met Arg Ala Phe Ser 
                165                 170                 175     


Ser Ser Thr Asn Leu Gln Glu Arg Phe Arg Arg Lys Asp 
            180                 185                 


<210>  487
<211>  193
<212>  PRT
<213>  Gallus gallus

<400>  487

Met Ala Val Pro Ala Ser Pro Gln His Pro Arg Gly Tyr Gly Ile Leu 
1               5                   10                  15      


Leu Leu Thr Leu Leu Leu Lys Ala Leu Ala Thr Thr Ala Ser Ala Cys 
            20                  25                  30          


Asn His Leu Arg Pro Gln Asp Ala Thr Phe Ser His Asp Ser Leu Gln 
        35                  40                  45              


Leu Leu Arg Asp Met Ala Pro Thr Leu Pro Gln Leu Cys Pro Gln His 
    50                  55                  60                  


Asn Ala Ser Cys Ser Phe Asn Asp Thr Ile Leu Asp Thr Ser Asn Thr 
65                  70                  75                  80  


Arg Gln Ala Asp Lys Thr Thr His Asp Ile Leu Gln His Leu Phe Lys 
                85                  90                  95      


Ile Leu Ser Ser Pro Ser Thr Pro Ala His Trp Asn Asp Ser Gln Arg 
            100                 105                 110         


Gln Ser Leu Leu Asn Arg Ile His Arg Tyr Thr Gln His Leu Glu Gln 
        115                 120                 125             


Cys Leu Asp Ser Ser Asp Thr Arg Ser Arg Thr Arg Trp Pro Arg Asn 
    130                 135                 140                 


Leu His Leu Thr Ile Lys Lys His Phe Ser Cys Leu His Thr Phe Leu 
145                 150                 155                 160 


Gln Asp Asn Asp Tyr Ser Ala Cys Ala Trp Glu His Val Arg Leu Gln 
                165                 170                 175     


Ala Arg Ala Trp Phe Leu His Ile His Asn Leu Thr Gly Asn Thr Arg 
            180                 185                 190         


Thr 
    


<210>  488
<211>  194
<212>  PRT
<213>  Felis catus

<400>  488

Met Ala Leu Pro Ser Ser Phe Leu Val Ala Leu Val Ala Leu Gly Cys 
1               5                   10                  15      


Asn Ser Val Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Gly Leu 
            20                  25                  30          


Leu Asn Arg Arg Ala Leu Thr Leu Leu Gly Gln Met Arg Arg Leu Pro 
        35                  40                  45              


Ala Ser Ser Cys Gln Lys Asp Arg Asn Asp Phe Ala Phe Pro Gln Asp 
    50                  55                  60                  


Val Phe Gly Gly Asp Gln Ser His Lys Ala Gln Ala Leu Ser Val Val 
65                  70                  75                  80  


His Val Thr Asn Gln Lys Ile Phe His Phe Phe Cys Thr Glu Ala Ser 
                85                  90                  95      


Ser Ser Ala Ala Trp Asn Thr Thr Leu Leu Glu Glu Phe Cys Thr Gly 
            100                 105                 110         


Leu Asp Arg Gln Leu Thr Arg Leu Glu Ala Cys Val Leu Gln Glu Val 
        115                 120                 125             


Glu Glu Gly Glu Ala Pro Leu Thr Asn Glu Asp Ile His Pro Glu Asp 
    130                 135                 140                 


Ser Ile Leu Arg Asn Tyr Phe Gln Arg Leu Ser Leu Tyr Leu Gln Glu 
145                 150                 155                 160 


Lys Lys Tyr Ser Pro Cys Ala Trp Glu Ile Val Arg Ala Glu Ile Met 
                165                 170                 175     


Arg Ser Leu Tyr Tyr Ser Ser Thr Ala Leu Gln Lys Arg Leu Arg Ser 
            180                 185                 190         


Glu Lys 
        


<210>  489
<211>  186
<212>  PRT
<213>  Sus scrofa

<400>  489

Met Ala Asn Lys Cys Ile Leu Gln Ile Ala Leu Leu Met Cys Phe Ser 
1               5                   10                  15      


Thr Thr Ala Leu Ser Met Ser Tyr Asp Val Leu Arg Tyr Gln Gln Arg 
            20                  25                  30          


Ser Ser Asn Leu Ala Cys Gln Lys Leu Leu Gly Gln Leu Pro Gly Thr 
        35                  40                  45              


Pro Gln Tyr Cys Leu Glu Asp Arg Met Asn Phe Glu Val Pro Glu Glu 
    50                  55                  60                  


Ile Met Gln Pro Pro Gln Phe Gln Lys Glu Asp Ala Val Leu Ile Ile 
65                  70                  75                  80  


His Glu Met Leu Gln Gln Ile Phe Gly Ile Leu Arg Arg Asn Phe Ser 
                85                  90                  95      


Ser Thr Gly Trp Asn Glu Thr Val Ile Lys Thr Ile Leu Val Glu Leu 
            100                 105                 110         


Asp Gly Gln Met Asp Asp Leu Glu Thr Ile Leu Glu Glu Ile Met Glu 
        115                 120                 125             


Glu Glu Asn Phe Pro Arg Gly Asp Met Thr Ile Leu His Leu Lys Lys 
    130                 135                 140                 


Tyr Tyr Leu Ser Ile Leu Gln Tyr Leu Lys Ser Lys Glu Tyr Arg Ser 
145                 150                 155                 160 


Cys Ala Trp Thr Val Val Gln Val Glu Ile Leu Arg Asn Phe Ser Phe 
                165                 170                 175     


Leu Asn Arg Leu Thr Asp Tyr Leu Arg Asn 
            180                 185     


<210>  490
<211>  186
<212>  PRT
<213>  Bos taurus

<400>  490

Met Thr His Arg Cys Leu Leu Gln Met Val Leu Leu Leu Cys Phe Ser 
1               5                   10                  15      


Thr Thr Ala Leu Ser Arg Ser Tyr Ser Leu Leu Arg Phe Gln Gln Arg 
            20                  25                  30          


Arg Ser Leu Ala Leu Cys Gln Lys Leu Leu Arg Gln Leu Pro Ser Thr 
        35                  40                  45              


Pro Gln His Cys Leu Glu Ala Arg Met Asp Phe Gln Met Pro Glu Glu 
    50                  55                  60                  


Met Lys Gln Ala Gln Gln Phe Gln Lys Glu Asp Ala Ile Leu Val Ile 
65                  70                  75                  80  


Tyr Glu Met Leu Gln Gln Ile Phe Asn Ile Leu Thr Arg Asp Phe Ser 
                85                  90                  95      


Ser Thr Gly Trp Ser Glu Thr Ile Ile Glu Asp Leu Leu Glu Glu Leu 
            100                 105                 110         


Tyr Glu Gln Met Asn His Leu Glu Pro Ile Gln Lys Glu Ile Met Gln 
        115                 120                 125             


Lys Gln Asn Ser Thr Met Gly Asp Thr Thr Val Leu His Leu Arg Lys 
    130                 135                 140                 


Tyr Tyr Phe Asn Leu Val Gln Tyr Leu Lys Ser Lys Glu Tyr Asn Arg 
145                 150                 155                 160 


Cys Ala Trp Thr Val Val Arg Val Gln Ile Leu Arg Asn Phe Ser Phe 
                165                 170                 175     


Leu Thr Arg Leu Thr Gly Tyr Leu Arg Glu 
            180                 185     


<210>  491
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Chain A, INTERFERON-ALPHA 2B 1RH2

<400>  491

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Asn 
            100                 105                 110         


Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu 
                165 


<210>  492
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  492

Ser Gly Gly Gly Gly 
1               5   


<210>  493
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProC288

<400>  493

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu Ser Gly Gly Gly Gly Ser Gly Arg Ser Asp Asn 
                165                 170                 175     


Ile Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
            180                 185                 190         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        195                 200                 205             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
    210                 215                 220                 


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
225                 230                 235                 240 


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
                245                 250                 255     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            260                 265                 270         


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
        275                 280                 285             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    290                 295                 300                 


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
305                 310                 315                 320 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                325                 330                 335     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            340                 345                 350         


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
        355                 360                 365             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    370                 375                 380                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
385                 390                 395     


<210>  494
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProC289

<400>  494

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu Ser Gly Gly Gly Gly Ser Gly Arg Ser Asp Asn 
                165                 170                 175     


Ile Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly 
            180                 185                 190         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        195                 200                 205             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
    210                 215                 220                 


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
225                 230                 235                 240 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
                245                 250                 255     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            260                 265                 270         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
        275                 280                 285             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    290                 295                 300                 


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
305                 310                 315                 320 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                325                 330                 335     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            340                 345                 350         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
        355                 360                 365             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    370                 375                 380                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
385                 390                 395                 


<210>  495
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProC290

<400>  495

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu Ser Gly Gly Gly Gly Ser Gly Arg Ser Asp Asn 
                165                 170                 175     


Ile Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu 
            180                 185                 190         


Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        195                 200                 205             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    210                 215                 220                 


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
225                 230                 235                 240 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                245                 250                 255     


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            260                 265                 270         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        275                 280                 285             


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    290                 295                 300                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
305                 310                 315                 320 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                325                 330                 335     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            340                 345                 350         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
        355                 360                 365             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    370                 375                 380                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
385                 390                 395                 400 


Ser Leu Ser 
            


<210>  496
<211>  407
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProC291

<400>  496

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu Ser Gly Gly Gly Gly Ser Gly Arg Ser Asp Asn 
                165                 170                 175     


Ile Gly Gly Gly Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
            180                 185                 190         


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        195                 200                 205             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    210                 215                 220                 


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
225                 230                 235                 240 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                245                 250                 255     


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            260                 265                 270         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        275                 280                 285             


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    290                 295                 300                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
305                 310                 315                 320 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                325                 330                 335     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            340                 345                 350         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        355                 360                 365             


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    370                 375                 380                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
385                 390                 395                 400 


Gln Lys Ser Leu Ser Leu Ser 
                405         


<210>  497
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProC441

<400>  497

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu Ser Gly Arg Ser Asp Asn Ile Gly Pro Pro Cys 
                165                 170                 175     


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
            180                 185                 190         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        195                 200                 205             


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
    210                 215                 220                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
225                 230                 235         


<210>  498
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProC442

<400>  498

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu Ser Gly Arg Ser Asp Asn Ile Glu Ser Lys Tyr 
                165                 170                 175     


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
            180                 185                 190         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        195                 200                 205             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
    210                 215                 220                 


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
225                 230                 235                 240 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
                245                 250                 255     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            260                 265                 270         


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
        275                 280                 285             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    290                 295                 300                 


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
305                 310                 315                 320 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                325                 330                 335     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            340                 345                 350         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
        355                 360                 365             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    370                 375                 380                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
385                 390                 395             


<210>  499
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ProC443

<400>  499

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu Ser Gly Arg Ser Asp Asn Ile Gly Gly Gly Ser 
                165                 170                 175     


Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
            180                 185                 190         


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        195                 200                 205             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    210                 215                 220                 


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
225                 230                 235                 240 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
                245                 250                 255     


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            260                 265                 270         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
        275                 280                 285             


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    290                 295                 300                 


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
305                 310                 315                 320 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                325                 330                 335     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            340                 345                 350         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
        355                 360                 365             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    370                 375                 380                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
385                 390                 395                 400 


Leu Ser 
        


<210>  500
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal sequence

<400>  500

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
1               5                   10      


<210>  501
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Non-cleavable moiety

<400>  501

Gly Gly Ser Gly Gly Gly Gly Ser 
1               5               


