                               SEQUENCE LISTING

<110> CEPTUR THERAPEUTICS, INC.
      RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
 
<120> COMPOSITIONS AND METHODS FOR KRAS GENE SILENCING

<130> 725848: SLG-001PC

<140>
<141>

<150> 63/240,736
<151> 2021-09-03

<150> 63/163,365
<151> 2021-03-19

<160> 30    

<170> PatentIn version 3.5

<210> 1
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1
agucugcaug gagcaggaaa                                                   20


<210> 2
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 2
agucugcaug gagcaggaaa                                                   20


<210> 3
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3
cagguaagua                                                              10


<210> 4
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 4
cagguaagua u                                                            11


<210> 5
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
gccagguaag uau                                                          13


<210> 6
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
cagguaagua                                                              10


<210> 7
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
cagguaagua u                                                            11


<210> 8
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
gccagguaag uau                                                          13


<210> 9
<211> 33
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 9
agucugcaug gagcaggaaa gccagguaag uau                                    33


<210> 10
<211> 33
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
agucugcaug gagcaggaaa gccagguaag uau                                    33


<210> 11
<211> 33
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
agucugcaug gagcaggaaa gccagguaag uau                                    33


<210> 12
<211> 33
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
agucugcaug gagcaggaaa gccagguaag uau                                    33


<210> 13
<211> 33
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
agucugcaug gagcaggaaa gccagguaag uau                                    33


<210> 14
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
agucugcaug gagcaggaaa cagguaagua                                        30


<210> 15
<211> 31
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
agucugcaug gagcaggaaa cagguaagua u                                      31


<210> 16
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 16
agucugcaug gagcaggaaa cagguaagua                                        30


<210> 17
<211> 31
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 17
agucugcaug gagcaggaaa cagguaagua u                                      31


<210> 18
<211> 33
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 18
agucugcaug gagcaggaaa gccagguaag uau                                    33


<210> 19
<211> 4666
<212> RNA
<213> Homo sapiens

<400> 19
gguguugaug augccuucua uacauuaguu cgagaaauuc gaaaacauaa agaaaagaug       60

agcaaagaug guaaaaagaa gaaaaagaag ucaaagacaa aguguguaau uauguaaaua      120

caauuuguac uuuuuucuua aggcauacua guacaagugg uaauuuuugu acauuacacu      180

aaauuauuag cauuuguuuu agcauuaccu aauuuuuuuc cugcuccaug cagacuguua      240

gcuuuuaccu uaaaugcuua uuuuaaaaug acaguggaag uuuuuuuuuc cucuaagugc      300

caguauuccc agaguuuugg uuuuugaacu agcaaugccu gugaaaaaga aacugaauac      360

cuaagauuuc ugucuugggg cuuuuggugc augcaguuga uuacuucuua uuuuucuuac      420

caauugugaa uguuggugug aaacaaauua augaagcuuu ugaaucaucc cuauucugug      480

uuuuaucuag ucacauaaau ggauuaauua cuaauuucag uugagaccuu cuaauugguu      540

uuuacugaaa cauugaggga acacaaauuu augggcuucc ugaugaugau ucuucuaggc      600

aucauguccu auaguuuguc aucccugaug aauguaaagu uacacuguuc acaaagguuu      660

ugucuccuuu ccacugcuau uagucauggu cacucucccc aaaauauuau auuuuuucua      720

uaaaaagaaa aaaauggaaa aaaauuacaa ggcaauggaa acuauuauaa ggccauuucc      780

uuuucacauu agauaaauua cuauaaagac uccuaauagc uuuuccuguu aaggcagacc      840

caguaugaaa uggggauuau uauagcaacc auuuuggggc uauauuuaca ugcuacuaaa      900

uuuuuauaau aauugaaaag auuuuaacaa guauaaaaaa uucucauagg aauuaaaugu      960

agucucccug ugucagacug cucuuucaua guauaacuuu aaaucuuuuc uucaacuuga     1020

gucuuugaag auaguuuuaa uucugcuugu gacauuaaaa gauuauuugg gccaguuaua     1080

gcuuauuagg uguugaagag accaagguug caaggccagg cccuguguga accuuugagc     1140

uuucauagag aguuucacag cauggacugu guccccacgg ucauccagug uugucaugca     1200

uugguuaguc aaaaugggga gggacuaggg caguuuggau agcucaacaa gauacaaucu     1260

cacucugugg ugguccugcu gacaaaucaa gagcauugcu uuuguuucuu aagaaaacaa     1320

acucuuuuuu aaaaauuacu uuuaaauauu aacucaaaag uugagauuuu gggguggugg     1380

ugugccaaga cauuaauuuu uuuuuuaaac aaugaaguga aaaaguuuua caaucucuag     1440

guuuggcuag uucucuuaac acugguuaaa uuaacauugc auaaacacuu uucaagucug     1500

auccauauuu aauaaugcuu uaaaauaaaa auaaaaacaa uccuuuugau aaauuuaaaa     1560

uguuacuuau uuuaaaauaa augaagugag auggcauggu gaggugaaag uaucacugga     1620

cuaggaagaa ggugacuuag guucuagaua ggugucuuuu aggacucuga uuuugaggac     1680

aucacuuacu auccauuucu ucauguuaaa agaagucauc ucaaacucuu aguuuuuuuu     1740

uuuuacaacu auguaauuua uauuccauuu acauaaggau acacuuauuu gucaagcuca     1800

gcacaaucug uaaauuuuua accuauguua caccaucuuc agugccaguc uugggcaaaa     1860

uugugcaaga ggugaaguuu auauuugaau auccauucuc guuuuaggac ucuucuucca     1920

uauuaguguc aucuugccuc ccuaccuucc acaugcccca ugacuugaug caguuuuaau     1980

acuuguaauu ccccuaacca uaagauuuac ugcugcugug gauaucucca ugaaguuuuc     2040

ccacugaguc acaucagaaa ugcccuacau cuuauuuccu cagggcucaa gagaaucuga     2100

cagauaccau aaagggauuu gaccuaauca cuaauuuuca ggugguggcu gaugcuuuga     2160

acaucucuuu gcugcccaau ccauuagcga caguaggauu uuucaaaccu gguaugaaua     2220

gacagaaccc uauccagugg aaggagaauu uaauaaagau agugcugaaa gaauuccuua     2280

gguaaucuau aacuaggacu acuccuggua acaguaauac auuccauugu uuuaguaacc     2340

agaaaucuuc augcaaugaa aaauacuuua auucaugaag cuuacuuuuu uuuuuuggug     2400

ucagagucuc gcucuuguca cccaggcugg aaugcagugg cgccaucuca gcucacugca     2460

accuccaucu cccagguuca agcgauucuc gugccucggc cuccugagua gcugggauua     2520

caggcgugug ccacuacacu caacuaauuu uuguauuuuu aggagagacg ggguuucacc     2580

cuguuggcca ggcuggucuc gaacuccuga ccucaaguga uucacccacc uuggccucau     2640

aaaccuguuu ugcagaacuc auuuauucag caaauauuua uugagugccu accagaugcc     2700

agucaccaca caaggcacug gguauauggu auccccaaac aagagacaua aucccggucc     2760

uuagguagug cuaguguggu cuguaauauc uuacuaaggc cuuugguaua cgacccagag     2820

auaacacgau gcguauuuua guuuugcaaa gaagggguuu ggucucugug ccagcucuau     2880

aauuguuuug cuacgauucc acugaaacuc uucgaucaag cuacuuuaug uaaaucacuu     2940

cauuguuuua aaggaauaaa cuugauuaua uuguuuuuuu auuuggcaua acugugauuc     3000

uuuuaggaca auuacuguac acauuaaggu guaugucaga uauucauauu gacccaaaug     3060

uguaauauuc caguuuucuc ugcauaagua auuaaaauau acuuaaaaau uaauaguuuu     3120

aucuggguac aaauaaacag gugccugaac uaguucacag acaaggaaac uucuauguaa     3180

aaaucacuau gauuucugaa uugcuaugug aaacuacaga ucuuuggaac acuguuuagg     3240

uaggguguua agacuuacac aguaccucgu uucuacacag agaaagaaau ggccauacuu     3300

caggaacugc agugcuuaug aggggauauu uaggccucuu gaauuuuuga uguagauggg     3360

cauuuuuuua agguaguggu uaauuaccuu uaugugaacu uugaaugguu uaacaaaaga     3420

uuuguuuuug uagagauuuu aaagggggag aauucuagaa auaaauguua ccuaauuauu     3480

acagccuuaa agacaaaaau ccuuguugaa guuuuuuuaa aaaaagcuaa auuacauaga     3540

cuuaggcauu aacauguuug uggaagaaua uagcagacgu auauuguauc auuugaguga     3600

auguucccaa guaggcauuc uaggcucuau uuaacugagu cacacugcau aggaauuuag     3660

aaccuaacuu uuauagguua ucaaaacugu ugucaccauu gcacaauuuu guccuaauau     3720

auacauagaa acuuuguggg gcauguuaag uuacaguuug cacaaguuca ucucauuugu     3780

auuccauuga uuuuuuuuuu cuucuaaaca uuuuuucuuc aaacaguaua uaacuuuuuu     3840

uaggggauuu uuuuuuagac agcaaaaacu aucugaagau uuccauuugu caaaaaguaa     3900

ugauuucuug auaauugugu aguaauguuu uuuagaaccc agcaguuacc uuaaagcuga     3960

auuuauauuu aguaacuucu guguuaauac uggauagcau gaauucugca uugagaaacu     4020

gaauagcugu cauaaaauga aacuuucuuu cuaaagaaag auacucacau gaguucuuga     4080

agaauaguca uaacuagauu aagaucugug uuuuaguuua auaguuugaa gugccuguuu     4140

gggauaauga uagguaauuu agaugaauuu aggggaaaaa aaaguuaucu gcagauaugu     4200

ugagggccca ucucuccccc cacaccccca cagagcuaac uggguuacag uguuuuaucc     4260

gaaaguuucc aauuccacug ucuuguguuu ucauguugaa aauacuuuug cauuuuuccu     4320

uugagugcca auuucuuacu aguacuauuu cuuaauguaa cauguuuacc uggaauguau     4380

uuuaacuauu uuuguauagu guaaacugaa acaugcacau uuuguacauu gugcuuucuu     4440

uugugggaca uaugcagugu gauccaguug uuuuccauca uuugguugcg cugaccuagg     4500

aauguugguc auaucaaaca uuaaaaauga ccacucuuuu aauugaaauu aacuuuuaaa     4560

uguuuauagg aguaugugcu gugaagugau cuaaaauuug uaauauuuuu gucaugaacu     4620

guacuacucc uaauuauugu aauguaauaa aaauaguuac agugac                    4666


<210> 20
<211> 20
<212> DNA
<213> Homo sapiens

<400> 20
tttcctgctc catgcagact                                                   20


<210> 21
<211> 14
<212> DNA
<213> Homo sapiens

<400> 21
tttcctgctc catg                                                         14


<210> 22
<211> 14
<212> DNA
<213> Homo sapiens

<400> 22
cctgctccat gcag                                                         14


<210> 23
<211> 14
<212> DNA
<213> Homo sapiens

<400> 23
gctccatgca gact                                                         14


<210> 24
<211> 164
<212> RNA
<213> Homo sapiens

<400> 24
auacuuaccu ggcaggggag auaccaugau cacgaaggug guuuucccag ggcgaggcuu       60

auccauugca cuccggaugu gcugaccccu gcgauuuccc caaauguggg aaacucgacu      120

gcauaauuug ugguaguggg ggacugcguu cgcgcuuucc ccug                       164


<210> 25
<211> 591
<212> PRT
<213> Homo sapiens

<400> 25
Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala His Arg 
1               5                   10                  15      


Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala 
            20                  25                  30          


Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu 
        35                  40                  45              


Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser 
    50                  55                  60                  


Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu 
65                  70                  75                  80  


Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys 
                85                  90                  95      


Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys 
            100                 105                 110         


Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val 
        115                 120                 125             


Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr 
    130                 135                 140                 


Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu 
145                 150                 155                 160 


Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln 
                165                 170                 175     


Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg 
            180                 185                 190         


Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Gly Leu Lys Cys Ala Ser 
        195                 200                 205             


Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg 
    210                 215                 220                 


Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu 
225                 230                 235                 240 


Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu 
                245                 250                 255     


Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu 
            260                 265                 270         


Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro 
        275                 280                 285             


Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met 
    290                 295                 300                 


Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Gly Ser Lys Asp 
305                 310                 315                 320 


Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe 
                325                 330                 335     


Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu 
            340                 345                 350         


Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala 
        355                 360                 365             


Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys 
    370                 375                 380                 


Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu 
385                 390                 395                 400 


Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg 
                405                 410                 415     


Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val 
            420                 425                 430         


Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu 
        435                 440                 445             


Ala Lys Arg Met Pro Cys Ala Glu Asp Cys Leu Ser Val Phe Leu Asn 
    450                 455                 460                 


Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr 
465                 470                 475                 480 


Lys Cys Cys Thr Glu Ser Leu Val Asn Gly Arg Pro Cys Phe Ser Ala 
                485                 490                 495     


Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr 
            500                 505                 510         


Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln 
        515                 520                 525             


Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys 
    530                 535                 540                 


Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe 
545                 550                 555                 560 


Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu 
                565                 570                 575     


Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585                 590     


<210> 26
<211> 609
<212> PRT
<213> Homo sapiens

<400> 26
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
    50                  55                  60                  


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
65                  70                  75                  80  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
                85                  90                  95      


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
            100                 105                 110         


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
        115                 120                 125             


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
    130                 135                 140                 


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
145                 150                 155                 160 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
                165                 170                 175     


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
            180                 185                 190         


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
        195                 200                 205             


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Gly Leu Lys Cys 
    210                 215                 220                 


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
225                 230                 235                 240 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
                245                 250                 255     


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
            260                 265                 270         


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
        275                 280                 285             


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
305                 310                 315                 320 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Gly Ser 
                325                 330                 335     


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
            340                 345                 350         


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
        355                 360                 365             


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
    370                 375                 380                 


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
385                 390                 395                 400 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
                405                 410                 415     


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
            420                 425                 430         


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
        435                 440                 445             


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
    450                 455                 460                 


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Cys Leu Ser Val Phe 
465                 470                 475                 480 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
                485                 490                 495     


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Gly Arg Pro Cys Phe 
            500                 505                 510         


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
        515                 520                 525             


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
    530                 535                 540                 


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
545                 550                 555                 560 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
                565                 570                 575     


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
        595                 600                 605             


Leu 
    


<210> 27
<211> 1008
<212> PRT
<213> Homo sapiens

<400> 27
Phe Asn Leu Asp Ala Glu Ala Pro Ala Val Leu Ser Gly Pro Pro Gly 
1               5                   10                  15      


Ser Phe Phe Gly Phe Ser Val Glu Phe Tyr Arg Pro Gly Thr Asp Gly 
            20                  25                  30          


Val Ser Val Leu Val Gly Ala Pro Lys Ala Asn Thr Ser Gln Pro Gly 
        35                  40                  45              


Val Leu Gln Gly Gly Ala Val Tyr Leu Cys Pro Trp Gly Ala Ser Pro 
    50                  55                  60                  


Thr Gln Cys Thr Pro Ile Glu Phe Asp Ser Lys Gly Ser Arg Leu Leu 
65                  70                  75                  80  


Glu Ser Ser Leu Ser Ser Ser Glu Gly Glu Glu Pro Val Glu Tyr Lys 
                85                  90                  95      


Ser Leu Gln Trp Phe Gly Ala Thr Val Arg Ala His Gly Ser Ser Ile 
            100                 105                 110         


Leu Ala Cys Ala Pro Leu Tyr Ser Trp Arg Thr Glu Lys Glu Pro Leu 
        115                 120                 125             


Ser Asp Pro Val Gly Thr Cys Tyr Leu Ser Thr Asp Asn Phe Thr Arg 
    130                 135                 140                 


Ile Leu Glu Tyr Ala Pro Cys Arg Ser Asp Phe Ser Trp Ala Ala Gly 
145                 150                 155                 160 


Gln Gly Tyr Cys Gln Gly Gly Phe Ser Ala Glu Phe Thr Lys Thr Gly 
                165                 170                 175     


Arg Val Val Leu Gly Gly Pro Gly Ser Tyr Phe Trp Gln Gly Gln Ile 
            180                 185                 190         


Leu Ser Ala Thr Gln Glu Gln Ile Ala Glu Ser Tyr Tyr Pro Glu Tyr 
        195                 200                 205             


Leu Ile Asn Leu Val Gln Gly Gln Leu Gln Thr Arg Gln Ala Ser Ser 
    210                 215                 220                 


Ile Tyr Asp Asp Ser Tyr Leu Gly Tyr Ser Val Ala Val Gly Glu Phe 
225                 230                 235                 240 


Ser Gly Asp Asp Thr Glu Asp Phe Val Ala Gly Val Pro Lys Gly Asn 
                245                 250                 255     


Leu Thr Tyr Gly Tyr Val Thr Ile Leu Asn Gly Ser Asp Ile Arg Ser 
            260                 265                 270         


Leu Tyr Asn Phe Ser Gly Glu Gln Met Ala Ser Tyr Phe Gly Tyr Ala 
        275                 280                 285             


Val Ala Ala Thr Asp Val Asn Gly Asp Gly Leu Asp Asp Leu Leu Val 
    290                 295                 300                 


Gly Ala Pro Leu Leu Met Asp Arg Thr Pro Asp Gly Arg Pro Gln Glu 
305                 310                 315                 320 


Val Gly Arg Val Tyr Val Tyr Leu Gln His Pro Ala Gly Ile Glu Pro 
                325                 330                 335     


Thr Pro Thr Leu Thr Leu Thr Gly His Asp Glu Phe Gly Arg Phe Gly 
            340                 345                 350         


Ser Ser Leu Thr Pro Leu Gly Asp Leu Asp Gln Asp Gly Tyr Asn Asp 
        355                 360                 365             


Val Ala Ile Gly Ala Pro Phe Gly Gly Glu Thr Gln Gln Gly Val Val 
    370                 375                 380                 


Phe Val Phe Pro Gly Gly Pro Gly Gly Leu Gly Ser Lys Pro Ser Gln 
385                 390                 395                 400 


Val Leu Gln Pro Leu Trp Ala Ala Ser His Thr Pro Asp Phe Phe Gly 
                405                 410                 415     


Ser Ala Leu Arg Gly Gly Arg Asp Leu Asp Gly Asn Gly Tyr Pro Asp 
            420                 425                 430         


Leu Ile Val Gly Ser Phe Gly Val Asp Lys Ala Val Val Tyr Arg Gly 
        435                 440                 445             


Arg Pro Ile Val Ser Ala Ser Ala Ser Leu Thr Ile Phe Pro Ala Met 
    450                 455                 460                 


Phe Asn Pro Glu Glu Arg Ser Cys Ser Leu Glu Gly Asn Pro Val Ala 
465                 470                 475                 480 


Cys Ile Asn Leu Ser Phe Cys Leu Asn Ala Ser Gly Lys His Val Ala 
                485                 490                 495     


Asp Ser Ile Gly Phe Thr Val Glu Leu Gln Leu Asp Trp Gln Lys Gln 
            500                 505                 510         


Lys Gly Gly Val Arg Arg Ala Leu Phe Leu Ala Ser Arg Gln Ala Thr 
        515                 520                 525             


Leu Thr Gln Thr Leu Leu Ile Gln Asn Gly Ala Arg Glu Asp Cys Arg 
    530                 535                 540                 


Glu Met Lys Ile Tyr Leu Arg Asn Glu Ser Glu Phe Arg Asp Lys Leu 
545                 550                 555                 560 


Ser Pro Ile His Ile Ala Leu Asn Phe Ser Leu Asp Pro Gln Ala Pro 
                565                 570                 575     


Val Asp Ser His Gly Leu Arg Pro Ala Leu His Tyr Gln Ser Lys Ser 
            580                 585                 590         


Arg Ile Glu Asp Lys Ala Gln Ile Leu Leu Asp Cys Gly Glu Asp Asn 
        595                 600                 605             


Ile Cys Val Pro Asp Leu Gln Leu Glu Val Phe Gly Glu Gln Asn His 
    610                 615                 620                 


Val Tyr Leu Gly Asp Lys Asn Ala Leu Asn Leu Thr Phe His Ala Gln 
625                 630                 635                 640 


Asn Val Gly Glu Gly Gly Ala Tyr Glu Ala Glu Leu Arg Val Thr Ala 
                645                 650                 655     


Pro Pro Glu Ala Glu Tyr Ser Gly Leu Val Arg His Pro Gly Asn Phe 
            660                 665                 670         


Ser Ser Leu Ser Cys Asp Tyr Phe Ala Val Asn Gln Ser Arg Leu Leu 
        675                 680                 685             


Val Cys Asp Leu Gly Asn Pro Met Lys Ala Gly Ala Ser Leu Trp Gly 
    690                 695                 700                 


Gly Leu Arg Phe Thr Val Pro His Leu Arg Asp Thr Lys Lys Thr Ile 
705                 710                 715                 720 


Gln Phe Asp Phe Gln Ile Leu Ser Lys Asn Leu Asn Asn Ser Gln Ser 
                725                 730                 735     


Asp Val Val Ser Phe Arg Leu Ser Val Glu Ala Gln Ala Gln Val Thr 
            740                 745                 750         


Leu Asn Gly Val Ser Lys Pro Glu Ala Val Leu Phe Pro Val Ser Asp 
        755                 760                 765             


Trp His Pro Arg Asp Gln Pro Gln Lys Glu Glu Asp Leu Gly Pro Ala 
    770                 775                 780                 


Val His His Val Tyr Glu Leu Ile Asn Gln Gly Pro Ser Ser Ile Ser 
785                 790                 795                 800 


Gln Gly Val Leu Glu Leu Ser Cys Pro Gln Ala Leu Glu Gly Gln Gln 
                805                 810                 815     


Leu Leu Tyr Val Thr Arg Val Thr Gly Leu Asn Cys Thr Thr Asn His 
            820                 825                 830         


Pro Ile Asn Pro Lys Gly Leu Glu Leu Asp Pro Glu Gly Ser Leu His 
        835                 840                 845             


His Gln Gln Lys Arg Glu Ala Pro Ser Arg Ser Ser Ala Ser Ser Gly 
    850                 855                 860                 


Pro Gln Ile Leu Lys Cys Pro Glu Ala Glu Cys Phe Arg Leu Arg Cys 
865                 870                 875                 880 


Glu Leu Gly Pro Leu His Gln Gln Glu Ser Gln Ser Leu Gln Leu His 
                885                 890                 895     


Phe Arg Val Trp Ala Lys Thr Phe Leu Gln Arg Glu His Gln Pro Phe 
            900                 905                 910         


Ser Leu Gln Cys Glu Ala Val Tyr Lys Ala Leu Lys Met Pro Tyr Arg 
        915                 920                 925             


Ile Leu Pro Arg Gln Leu Pro Gln Lys Glu Arg Gln Val Ala Thr Ala 
    930                 935                 940                 


Val Gln Trp Thr Lys Ala Glu Gly Ser Tyr Gly Val Pro Leu Trp Ile 
945                 950                 955                 960 


Ile Ile Leu Ala Ile Leu Phe Gly Leu Leu Leu Leu Gly Leu Leu Ile 
                965                 970                 975     


Tyr Ile Leu Tyr Lys Leu Gly Phe Phe Lys Arg Ser Leu Pro Tyr Gly 
            980                 985                 990         


Thr Ala Met Glu Lys Ala Gln Leu  Lys Pro Pro Ala Thr  Ser Asp Ala 
        995                 1000                 1005             


<210> 28
<211> 1049
<212> PRT
<213> Homo sapiens

<400> 28
Met Gly Ser Arg Thr Pro Glu Ser Pro Leu His Ala Val Gln Leu Arg 
1               5                   10                  15      


Trp Gly Pro Arg Arg Arg Pro Pro Leu Leu Pro Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Pro Pro Pro Pro Arg Val Gly Gly Phe Asn Leu Asp Ala Glu Ala 
        35                  40                  45              


Pro Ala Val Leu Ser Gly Pro Pro Gly Ser Phe Phe Gly Phe Ser Val 
    50                  55                  60                  


Glu Phe Tyr Arg Pro Gly Thr Asp Gly Val Ser Val Leu Val Gly Ala 
65                  70                  75                  80  


Pro Lys Ala Asn Thr Ser Gln Pro Gly Val Leu Gln Gly Gly Ala Val 
                85                  90                  95      


Tyr Leu Cys Pro Trp Gly Ala Ser Pro Thr Gln Cys Thr Pro Ile Glu 
            100                 105                 110         


Phe Asp Ser Lys Gly Ser Arg Leu Leu Glu Ser Ser Leu Ser Ser Ser 
        115                 120                 125             


Glu Gly Glu Glu Pro Val Glu Tyr Lys Ser Leu Gln Trp Phe Gly Ala 
    130                 135                 140                 


Thr Val Arg Ala His Gly Ser Ser Ile Leu Ala Cys Ala Pro Leu Tyr 
145                 150                 155                 160 


Ser Trp Arg Thr Glu Lys Glu Pro Leu Ser Asp Pro Val Gly Thr Cys 
                165                 170                 175     


Tyr Leu Ser Thr Asp Asn Phe Thr Arg Ile Leu Glu Tyr Ala Pro Cys 
            180                 185                 190         


Arg Ser Asp Phe Ser Trp Ala Ala Gly Gln Gly Tyr Cys Gln Gly Gly 
        195                 200                 205             


Phe Ser Ala Glu Phe Thr Lys Thr Gly Arg Val Val Leu Gly Gly Pro 
    210                 215                 220                 


Gly Ser Tyr Phe Trp Gln Gly Gln Ile Leu Ser Ala Thr Gln Glu Gln 
225                 230                 235                 240 


Ile Ala Glu Ser Tyr Tyr Pro Glu Tyr Leu Ile Asn Leu Val Gln Gly 
                245                 250                 255     


Gln Leu Gln Thr Arg Gln Ala Ser Ser Ile Tyr Asp Asp Ser Tyr Leu 
            260                 265                 270         


Gly Tyr Ser Val Ala Val Gly Glu Phe Ser Gly Asp Asp Thr Glu Asp 
        275                 280                 285             


Phe Val Ala Gly Val Pro Lys Gly Asn Leu Thr Tyr Gly Tyr Val Thr 
    290                 295                 300                 


Ile Leu Asn Gly Ser Asp Ile Arg Ser Leu Tyr Asn Phe Ser Gly Glu 
305                 310                 315                 320 


Gln Met Ala Ser Tyr Phe Gly Tyr Ala Val Ala Ala Thr Asp Val Asn 
                325                 330                 335     


Gly Asp Gly Leu Asp Asp Leu Leu Val Gly Ala Pro Leu Leu Met Asp 
            340                 345                 350         


Arg Thr Pro Asp Gly Arg Pro Gln Glu Val Gly Arg Val Tyr Val Tyr 
        355                 360                 365             


Leu Gln His Pro Ala Gly Ile Glu Pro Thr Pro Thr Leu Thr Leu Thr 
    370                 375                 380                 


Gly His Asp Glu Phe Gly Arg Phe Gly Ser Ser Leu Thr Pro Leu Gly 
385                 390                 395                 400 


Asp Leu Asp Gln Asp Gly Tyr Asn Asp Val Ala Ile Gly Ala Pro Phe 
                405                 410                 415     


Gly Gly Glu Thr Gln Gln Gly Val Val Phe Val Phe Pro Gly Gly Pro 
            420                 425                 430         


Gly Gly Leu Gly Ser Lys Pro Ser Gln Val Leu Gln Pro Leu Trp Ala 
        435                 440                 445             


Ala Ser His Thr Pro Asp Phe Phe Gly Ser Ala Leu Arg Gly Gly Arg 
    450                 455                 460                 


Asp Leu Asp Gly Asn Gly Tyr Pro Asp Leu Ile Val Gly Ser Phe Gly 
465                 470                 475                 480 


Val Asp Lys Ala Val Val Tyr Arg Gly Arg Pro Ile Val Ser Ala Ser 
                485                 490                 495     


Ala Ser Leu Thr Ile Phe Pro Ala Met Phe Asn Pro Glu Glu Arg Ser 
            500                 505                 510         


Cys Ser Leu Glu Gly Asn Pro Val Ala Cys Ile Asn Leu Ser Phe Cys 
        515                 520                 525             


Leu Asn Ala Ser Gly Lys His Val Ala Asp Ser Ile Gly Phe Thr Val 
    530                 535                 540                 


Glu Leu Gln Leu Asp Trp Gln Lys Gln Lys Gly Gly Val Arg Arg Ala 
545                 550                 555                 560 


Leu Phe Leu Ala Ser Arg Gln Ala Thr Leu Thr Gln Thr Leu Leu Ile 
                565                 570                 575     


Gln Asn Gly Ala Arg Glu Asp Cys Arg Glu Met Lys Ile Tyr Leu Arg 
            580                 585                 590         


Asn Glu Ser Glu Phe Arg Asp Lys Leu Ser Pro Ile His Ile Ala Leu 
        595                 600                 605             


Asn Phe Ser Leu Asp Pro Gln Ala Pro Val Asp Ser His Gly Leu Arg 
    610                 615                 620                 


Pro Ala Leu His Tyr Gln Ser Lys Ser Arg Ile Glu Asp Lys Ala Gln 
625                 630                 635                 640 


Ile Leu Leu Asp Cys Gly Glu Asp Asn Ile Cys Val Pro Asp Leu Gln 
                645                 650                 655     


Leu Glu Val Phe Gly Glu Gln Asn His Val Tyr Leu Gly Asp Lys Asn 
            660                 665                 670         


Ala Leu Asn Leu Thr Phe His Ala Gln Asn Val Gly Glu Gly Gly Ala 
        675                 680                 685             


Tyr Glu Ala Glu Leu Arg Val Thr Ala Pro Pro Glu Ala Glu Tyr Ser 
    690                 695                 700                 


Gly Leu Val Arg His Pro Gly Asn Phe Ser Ser Leu Ser Cys Asp Tyr 
705                 710                 715                 720 


Phe Ala Val Asn Gln Ser Arg Leu Leu Val Cys Asp Leu Gly Asn Pro 
                725                 730                 735     


Met Lys Ala Gly Ala Ser Leu Trp Gly Gly Leu Arg Phe Thr Val Pro 
            740                 745                 750         


His Leu Arg Asp Thr Lys Lys Thr Ile Gln Phe Asp Phe Gln Ile Leu 
        755                 760                 765             


Ser Lys Asn Leu Asn Asn Ser Gln Ser Asp Val Val Ser Phe Arg Leu 
    770                 775                 780                 


Ser Val Glu Ala Gln Ala Gln Val Thr Leu Asn Gly Val Ser Lys Pro 
785                 790                 795                 800 


Glu Ala Val Leu Phe Pro Val Ser Asp Trp His Pro Arg Asp Gln Pro 
                805                 810                 815     


Gln Lys Glu Glu Asp Leu Gly Pro Ala Val His His Val Tyr Glu Leu 
            820                 825                 830         


Ile Asn Gln Gly Pro Ser Ser Ile Ser Gln Gly Val Leu Glu Leu Ser 
        835                 840                 845             


Cys Pro Gln Ala Leu Glu Gly Gln Gln Leu Leu Tyr Val Thr Arg Val 
    850                 855                 860                 


Thr Gly Leu Asn Cys Thr Thr Asn His Pro Ile Asn Pro Lys Gly Leu 
865                 870                 875                 880 


Glu Leu Asp Pro Glu Gly Ser Leu His His Gln Gln Lys Arg Glu Ala 
                885                 890                 895     


Pro Ser Arg Ser Ser Ala Ser Ser Gly Pro Gln Ile Leu Lys Cys Pro 
            900                 905                 910         


Glu Ala Glu Cys Phe Arg Leu Arg Cys Glu Leu Gly Pro Leu His Gln 
        915                 920                 925             


Gln Glu Ser Gln Ser Leu Gln Leu His Phe Arg Val Trp Ala Lys Thr 
    930                 935                 940                 


Phe Leu Gln Arg Glu His Gln Pro Phe Ser Leu Gln Cys Glu Ala Val 
945                 950                 955                 960 


Tyr Lys Ala Leu Lys Met Pro Tyr Arg Ile Leu Pro Arg Gln Leu Pro 
                965                 970                 975     


Gln Lys Glu Arg Gln Val Ala Thr Ala Val Gln Trp Thr Lys Ala Glu 
            980                 985                 990         


Gly Ser Tyr Gly Val Pro Leu Trp  Ile Ile Ile Leu Ala  Ile Leu Phe 
        995                 1000                 1005             


Gly Leu  Leu Leu Leu Gly Leu  Leu Ile Tyr Ile Leu  Tyr Lys Leu 
    1010                 1015                 1020             


Gly Phe  Phe Lys Arg Ser Leu  Pro Tyr Gly Thr Ala  Met Glu Lys 
    1025                 1030                 1035             


Ala Gln  Leu Lys Pro Pro Ala  Thr Ser Asp Ala 
    1040                 1045                 


<210> 29
<211> 762
<212> PRT
<213> Homo sapiens

<400> 29
Gly Pro Asn Ile Cys Thr Thr Arg Gly Val Ser Ser Cys Gln Gln Cys 
1               5                   10                  15      


Leu Ala Val Ser Pro Met Cys Ala Trp Cys Ser Asp Glu Ala Leu Pro 
            20                  25                  30          


Leu Gly Ser Pro Arg Cys Asp Leu Lys Glu Asn Leu Leu Lys Asp Asn 
        35                  40                  45              


Cys Ala Pro Glu Ser Ile Glu Phe Pro Val Ser Glu Ala Arg Val Leu 
    50                  55                  60                  


Glu Asp Arg Pro Leu Ser Asp Lys Gly Ser Gly Asp Ser Ser Gln Val 
65                  70                  75                  80  


Thr Gln Val Ser Pro Gln Arg Ile Ala Leu Arg Leu Arg Pro Asp Asp 
                85                  90                  95      


Ser Lys Asn Phe Ser Ile Gln Val Arg Gln Val Glu Asp Tyr Pro Val 
            100                 105                 110         


Asp Ile Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu 
        115                 120                 125             


Trp Ser Ile Gln Asn Leu Gly Thr Lys Leu Ala Thr Gln Met Arg Lys 
    130                 135                 140                 


Leu Thr Ser Asn Leu Arg Ile Gly Phe Gly Ala Phe Val Asp Lys Pro 
145                 150                 155                 160 


Val Ser Pro Tyr Met Tyr Ile Ser Pro Pro Glu Ala Leu Glu Asn Pro 
                165                 170                 175     


Cys Tyr Asp Met Lys Thr Thr Cys Leu Pro Met Phe Gly Tyr Lys His 
            180                 185                 190         


Val Leu Thr Leu Thr Asp Gln Val Thr Arg Phe Asn Glu Glu Val Lys 
        195                 200                 205             


Lys Gln Ser Val Ser Arg Asn Arg Asp Ala Pro Glu Gly Gly Phe Asp 
    210                 215                 220                 


Ala Ile Met Gln Ala Thr Val Cys Asp Glu Lys Ile Gly Trp Arg Asn 
225                 230                 235                 240 


Asp Ala Ser His Leu Leu Val Phe Thr Thr Asp Ala Lys Thr His Ile 
                245                 250                 255     


Ala Leu Asp Gly Arg Leu Ala Gly Ile Val Gln Pro Asn Asp Gly Gln 
            260                 265                 270         


Cys His Val Gly Ser Asp Asn His Tyr Ser Ala Ser Thr Thr Met Asp 
        275                 280                 285             


Tyr Pro Ser Leu Gly Leu Met Thr Glu Lys Leu Ser Gln Lys Asn Ile 
    290                 295                 300                 


Asn Leu Ile Phe Ala Val Thr Glu Asn Val Val Asn Leu Tyr Gln Asn 
305                 310                 315                 320 


Tyr Ser Glu Leu Ile Pro Gly Thr Thr Val Gly Val Leu Ser Met Asp 
                325                 330                 335     


Ser Ser Asn Val Leu Gln Leu Ile Val Asp Ala Tyr Gly Lys Ile Arg 
            340                 345                 350         


Ser Lys Val Glu Leu Glu Val Arg Asp Leu Pro Glu Glu Leu Ser Leu 
        355                 360                 365             


Ser Phe Asn Ala Thr Cys Leu Asn Asn Glu Val Ile Pro Gly Leu Lys 
    370                 375                 380                 


Ser Cys Met Gly Leu Lys Ile Gly Asp Thr Val Ser Phe Ser Ile Glu 
385                 390                 395                 400 


Ala Lys Val Arg Gly Cys Pro Gln Glu Lys Glu Lys Ser Phe Thr Ile 
                405                 410                 415     


Lys Pro Val Gly Phe Lys Asp Ser Leu Ile Val Gln Val Thr Phe Asp 
            420                 425                 430         


Cys Asp Cys Ala Cys Gln Ala Gln Ala Glu Pro Asn Ser His Arg Cys 
        435                 440                 445             


Asn Asn Gly Asn Gly Thr Phe Glu Cys Gly Val Cys Arg Cys Gly Pro 
    450                 455                 460                 


Gly Trp Leu Gly Ser Gln Cys Glu Cys Ser Glu Glu Asp Tyr Arg Pro 
465                 470                 475                 480 


Ser Gln Gln Asp Glu Cys Ser Pro Arg Glu Gly Gln Pro Val Cys Ser 
                485                 490                 495     


Gln Arg Gly Glu Cys Leu Cys Gly Gln Cys Val Cys His Ser Ser Asp 
            500                 505                 510         


Phe Gly Lys Ile Thr Gly Lys Tyr Cys Glu Cys Asp Asp Phe Ser Cys 
        515                 520                 525             


Val Arg Tyr Lys Gly Glu Met Cys Ser Gly His Gly Gln Cys Ser Cys 
    530                 535                 540                 


Gly Asp Cys Leu Cys Asp Ser Asp Trp Thr Gly Tyr Tyr Cys Asn Cys 
545                 550                 555                 560 


Thr Thr Arg Thr Asp Thr Cys Met Ser Ser Asn Gly Leu Leu Cys Ser 
                565                 570                 575     


Gly Arg Gly Lys Cys Glu Cys Gly Ser Cys Val Cys Ile Gln Pro Gly 
            580                 585                 590         


Ser Tyr Gly Asp Thr Cys Glu Lys Cys Pro Thr Cys Pro Asp Ala Cys 
        595                 600                 605             


Thr Phe Lys Lys Glu Cys Val Glu Cys Lys Lys Phe Asp Arg Gly Ala 
    610                 615                 620                 


Leu His Asp Glu Asn Thr Cys Asn Arg Tyr Cys Arg Asp Glu Ile Glu 
625                 630                 635                 640 


Ser Val Lys Glu Leu Lys Asp Thr Gly Lys Asp Ala Val Asn Cys Thr 
                645                 650                 655     


Tyr Lys Asn Glu Asp Asp Cys Val Val Arg Phe Gln Tyr Tyr Glu Asp 
            660                 665                 670         


Ser Ser Gly Lys Ser Ile Leu Tyr Val Val Glu Glu Pro Glu Cys Pro 
        675                 680                 685             


Lys Gly Pro Asp Ile Leu Val Val Leu Leu Ser Val Met Gly Ala Ile 
    690                 695                 700                 


Leu Leu Ile Gly Leu Ala Ala Leu Leu Ile Trp Lys Leu Leu Ile Thr 
705                 710                 715                 720 


Ile His Asp Arg Lys Glu Phe Ala Lys Phe Glu Glu Glu Arg Ala Arg 
                725                 730                 735     


Ala Lys Trp Asp Thr Ala Asn Asn Pro Leu Tyr Lys Glu Ala Thr Ser 
            740                 745                 750         


Thr Phe Thr Asn Ile Thr Tyr Arg Gly Thr 
        755                 760         


<210> 30
<211> 788
<212> PRT
<213> Homo sapiens

<400> 30
Met Arg Ala Arg Pro Arg Pro Arg Pro Leu Trp Ala Thr Val Leu Ala 
1               5                   10                  15      


Leu Gly Ala Leu Ala Gly Val Gly Val Gly Gly Pro Asn Ile Cys Thr 
            20                  25                  30          


Thr Arg Gly Val Ser Ser Cys Gln Gln Cys Leu Ala Val Ser Pro Met 
        35                  40                  45              


Cys Ala Trp Cys Ser Asp Glu Ala Leu Pro Leu Gly Ser Pro Arg Cys 
    50                  55                  60                  


Asp Leu Lys Glu Asn Leu Leu Lys Asp Asn Cys Ala Pro Glu Ser Ile 
65                  70                  75                  80  


Glu Phe Pro Val Ser Glu Ala Arg Val Leu Glu Asp Arg Pro Leu Ser 
                85                  90                  95      


Asp Lys Gly Ser Gly Asp Ser Ser Gln Val Thr Gln Val Ser Pro Gln 
            100                 105                 110         


Arg Ile Ala Leu Arg Leu Arg Pro Asp Asp Ser Lys Asn Phe Ser Ile 
        115                 120                 125             


Gln Val Arg Gln Val Glu Asp Tyr Pro Val Asp Ile Tyr Tyr Leu Met 
    130                 135                 140                 


Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Trp Ser Ile Gln Asn Leu 
145                 150                 155                 160 


Gly Thr Lys Leu Ala Thr Gln Met Arg Lys Leu Thr Ser Asn Leu Arg 
                165                 170                 175     


Ile Gly Phe Gly Ala Phe Val Asp Lys Pro Val Ser Pro Tyr Met Tyr 
            180                 185                 190         


Ile Ser Pro Pro Glu Ala Leu Glu Asn Pro Cys Tyr Asp Met Lys Thr 
        195                 200                 205             


Thr Cys Leu Pro Met Phe Gly Tyr Lys His Val Leu Thr Leu Thr Asp 
    210                 215                 220                 


Gln Val Thr Arg Phe Asn Glu Glu Val Lys Lys Gln Ser Val Ser Arg 
225                 230                 235                 240 


Asn Arg Asp Ala Pro Glu Gly Gly Phe Asp Ala Ile Met Gln Ala Thr 
                245                 250                 255     


Val Cys Asp Glu Lys Ile Gly Trp Arg Asn Asp Ala Ser His Leu Leu 
            260                 265                 270         


Val Phe Thr Thr Asp Ala Lys Thr His Ile Ala Leu Asp Gly Arg Leu 
        275                 280                 285             


Ala Gly Ile Val Gln Pro Asn Asp Gly Gln Cys His Val Gly Ser Asp 
    290                 295                 300                 


Asn His Tyr Ser Ala Ser Thr Thr Met Asp Tyr Pro Ser Leu Gly Leu 
305                 310                 315                 320 


Met Thr Glu Lys Leu Ser Gln Lys Asn Ile Asn Leu Ile Phe Ala Val 
                325                 330                 335     


Thr Glu Asn Val Val Asn Leu Tyr Gln Asn Tyr Ser Glu Leu Ile Pro 
            340                 345                 350         


Gly Thr Thr Val Gly Val Leu Ser Met Asp Ser Ser Asn Val Leu Gln 
        355                 360                 365             


Leu Ile Val Asp Ala Tyr Gly Lys Ile Arg Ser Lys Val Glu Leu Glu 
    370                 375                 380                 


Val Arg Asp Leu Pro Glu Glu Leu Ser Leu Ser Phe Asn Ala Thr Cys 
385                 390                 395                 400 


Leu Asn Asn Glu Val Ile Pro Gly Leu Lys Ser Cys Met Gly Leu Lys 
                405                 410                 415     


Ile Gly Asp Thr Val Ser Phe Ser Ile Glu Ala Lys Val Arg Gly Cys 
            420                 425                 430         


Pro Gln Glu Lys Glu Lys Ser Phe Thr Ile Lys Pro Val Gly Phe Lys 
        435                 440                 445             


Asp Ser Leu Ile Val Gln Val Thr Phe Asp Cys Asp Cys Ala Cys Gln 
    450                 455                 460                 


Ala Gln Ala Glu Pro Asn Ser His Arg Cys Asn Asn Gly Asn Gly Thr 
465                 470                 475                 480 


Phe Glu Cys Gly Val Cys Arg Cys Gly Pro Gly Trp Leu Gly Ser Gln 
                485                 490                 495     


Cys Glu Cys Ser Glu Glu Asp Tyr Arg Pro Ser Gln Gln Asp Glu Cys 
            500                 505                 510         


Ser Pro Arg Glu Gly Gln Pro Val Cys Ser Gln Arg Gly Glu Cys Leu 
        515                 520                 525             


Cys Gly Gln Cys Val Cys His Ser Ser Asp Phe Gly Lys Ile Thr Gly 
    530                 535                 540                 


Lys Tyr Cys Glu Cys Asp Asp Phe Ser Cys Val Arg Tyr Lys Gly Glu 
545                 550                 555                 560 


Met Cys Ser Gly His Gly Gln Cys Ser Cys Gly Asp Cys Leu Cys Asp 
                565                 570                 575     


Ser Asp Trp Thr Gly Tyr Tyr Cys Asn Cys Thr Thr Arg Thr Asp Thr 
            580                 585                 590         


Cys Met Ser Ser Asn Gly Leu Leu Cys Ser Gly Arg Gly Lys Cys Glu 
        595                 600                 605             


Cys Gly Ser Cys Val Cys Ile Gln Pro Gly Ser Tyr Gly Asp Thr Cys 
    610                 615                 620                 


Glu Lys Cys Pro Thr Cys Pro Asp Ala Cys Thr Phe Lys Lys Glu Cys 
625                 630                 635                 640 


Val Glu Cys Lys Lys Phe Asp Arg Gly Ala Leu His Asp Glu Asn Thr 
                645                 650                 655     


Cys Asn Arg Tyr Cys Arg Asp Glu Ile Glu Ser Val Lys Glu Leu Lys 
            660                 665                 670         


Asp Thr Gly Lys Asp Ala Val Asn Cys Thr Tyr Lys Asn Glu Asp Asp 
        675                 680                 685             


Cys Val Val Arg Phe Gln Tyr Tyr Glu Asp Ser Ser Gly Lys Ser Ile 
    690                 695                 700                 


Leu Tyr Val Val Glu Glu Pro Glu Cys Pro Lys Gly Pro Asp Ile Leu 
705                 710                 715                 720 


Val Val Leu Leu Ser Val Met Gly Ala Ile Leu Leu Ile Gly Leu Ala 
                725                 730                 735     


Ala Leu Leu Ile Trp Lys Leu Leu Ile Thr Ile His Asp Arg Lys Glu 
            740                 745                 750         


Phe Ala Lys Phe Glu Glu Glu Arg Ala Arg Ala Lys Trp Asp Thr Ala 
        755                 760                 765             


Asn Asn Pro Leu Tyr Lys Glu Ala Thr Ser Thr Phe Thr Asn Ile Thr 
    770                 775                 780                 


Tyr Arg Gly Thr 
785             


