<110>    Korea Research Institute of Bioscience and Biotechnology

<120>    Novel bicyclic compounds, or optical isomer thereof, or
         pharmaceutically acceptable salts thereof, uses thereof, and
         preparation method thereof

<130>    P22027-KRIBB-PA

<150>    KR 10-2021-0033075
<151>    2021-03-15

<160>    9

<170>    KoPatentIn 3.0

<210>    1
<211>    1464
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    KCTC 14890BP


<400>    1
atccgagttt gatcatggct caggacgaac gctggcggcg tgcttaacac atgcaagtcg         60

aacgatgaac cggtttcggc cggggattag tggcgaacgg gtgagtaaca cgtgggcaat        120

ctgccctgca ctctgggaca agccctggaa acggggtcta ataccggata tgactaccga        180

ccgcatggtc tggtggtgga aagctccggc ggtgcaggat gagcccgcgg cctatcagct        240

tgttggtggg gtgatggcct accaaggcga cgacgggtag ccggcctgag agggcgaccg        300

gccacactgg gactgagaca cggcccagac tcctacggga ggcagcagtg gggaatattg        360

cacaatgggc ggaagcctga tgcagcgacg ccgcgtgagg gatgacggcc ttcgggttgt        420

aaacctcttt cagcagggaa gaagcgcaag tgacggtacc tgcagaagaa gcgccggcta        480

actacgtgcc agcagccgcg gtaatacgta gggcgcaagc gttgtccgga attattgggc        540

gtaaagagct cgtaggcggc ttgtcgcgtc ggatgtgaaa gcccggggct taaccccggg        600

tctgcattcg atacgggcag gctagagttc ggtaggggag atcggaattc ctggtgtagc        660

ggtgaaatgc gcagatatca ggaggaacac cggtggcgaa ggcggatctc tgggccgata        720

ctgacgctga ggagcgaaag cgtggggagc gaacaggatt agataccctg gtagtccacg        780

ccgtaaacgt tgggaactag gtgtgggcga cattccacgt tgtccgtgcc gcagctaacg        840

cattaagttc cccgcctggg gagtacggcc gcaaggctaa aactcaaagg aattgacggg        900

ggcccgcaca agcggcggag catgtggctt aattcgacgc aacgcgaaga accttaccaa        960

ggcttgacat acatcggaaa catccagaga tgggtgcccc cttgtggtcg gtgtacaggt       1020

ggtgcatggc tgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg caacgagcgc       1080

aacccttgtt ctgtgttgcc agcatgcctt tcggggtgat ggggactcac aggagactgc       1140

cggggtcaac tcggaggaag gtggggacga cgtcaagtca tcatgcccct tatgtcttgg       1200

gctgcacacg tgctacaatg gccggtacaa tgagctgcga agccgtgagg tggagcgaat       1260

ctcaaaaagc cggtctcagt tcggattggg gtctgcaact cgaccccatg aagtcggagt       1320

cgctagtaat cgcagatcag cattgctgcg gtgaatacgt tcccgggcct tgtacacacc       1380

gcccgtcacg tcacgaaagt cggtaacacc cgaagccggt ggcccaaccc ttgtggaggg       1440

agctgtcgaa gtgggactgg cgat                                              1464


<210>    2
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    mCol1a1 Forward


<400>    2
cgaaggcaac agtcgcttca                                                     20


<210>    3
<211>    17
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    mCol1a1 Reverse


<400>    3
cccaagttcc ggtgtga                                                        17


<210>    4
<211>    22
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    mOsteocalcin Forward


<400>    4
cctgagtctg acaaagcctt ca                                                  22


<210>    5
<211>    22
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    mOsteocalcin Reverse


<400>    5
gccggagtct gttcactacc tt                                                  22


<210>    6
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    mOsterix Forward


<400>    6
agcgaccact tgagcaaaca t                                                   21


<210>    7
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    mOsterix Reverse


<400>    7
gcggctgatt ggcttcttct                                                     20


<210>    8
<211>    22
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    mGAPDH Forward


<400>    8
catggcctcc aaaggagtaa ga                                                  22


<210>    9
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    mGAPDH Reverse


<400>    9
gagggagatg ctcagtgttg g                                                   21
