                         SEQUENCE LISTING

<110>  UCL Business Ltd
 
<120>  CD160 BINDING DOMAIN

<130>  P122262PCT

<140>  PCT/GB2021/052862
<141>  2021-11-04

<150>  GB 2103706.4
<151>  2021-03-17

<160>  188   

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 Binding Domain HCDR1

<400>  1

Gly Phe Ile Phe Ser Asn Tyr Ala 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 Binding Domain HCDR2

<400>  2

Val Asn Ser Gly Gly Ala Asn Thr 
1               5               


<210>  3
<211>  12
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 Binding Domain HCDR3

<400>  3

Ala Thr His Asn Tyr Glu Ser Thr Val Phe Asp Tyr 
1               5                   10          


<210>  4
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 Binding Domain LCDR1

<400>  4

Ser Ser Val Ser Tyr 
1               5   


<210>  5
<211>  3
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 Binding Domain LCDR2

<400>  5

Glu Thr Ser 
1           


<210>  6
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 Binding Domain LCDR3

<400>  6

Gln Gln Trp Asn Tyr Pro Ser Met Tyr Thr 
1               5                   10  


<210>  7
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 Binding Domain HCDR1

<400>  7

Gly Phe Thr Phe Ser Asn Tyr Gly 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 Binding Domain HCDR2

<400>  8

Val Ser Asn Gly Gly Gly Asn Thr 
1               5               


<210>  9
<211>  12
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 Binding Domain HCDR3

<400>  9

Val Thr His Asn Tyr Glu Ser Thr Val Phe Asp Tyr 
1               5                   10          


<210>  10
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 Binding Domain HCDR1

<400>  10

Gly Phe Ser Leu Thr Ser Tyr Gly 
1               5               


<210>  11
<211>  7
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 Binding Domain HCDR2

<400>  11

Ile Trp Asn Asp Gly Gly Thr 
1               5           


<210>  12
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 Binding Domain HCDR3

<400>  12

Ala Arg Gly Trp Thr His 
1               5       


<210>  13
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 Binding Domain LCDR1

<400>  13

Glu Asp Ile Tyr Asn Asn 
1               5       


<210>  14
<211>  3
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 Binding Domain LCDR2

<400>  14

Tyr Ala Ser 
1           


<210>  15
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 Binding Domain LCDR3

<400>  15

Leu Gln Asp Ser Glu Tyr Pro Pro Thr 
1               5                   


<210>  16
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 Binding Domain HCDR2

<400>  16

Ile Ser Thr Gly Asp Asp Asn Thr 
1               5               


<210>  17
<211>  12
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 Binding Domain HCDR3

<400>  17

Ala Thr His Asn Tyr Glu Ser Thr Ile Phe Asp Tyr 
1               5                   10          


<210>  18
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 Binding Domain HCDR1

<400>  18

Gly Phe Ser Leu Thr Asn Tyr Gly 
1               5               


<210>  19
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  CD160  Binding Domain HCDR3

<400>  19

Ala Arg Gly Met Glu Ala 
1               5       


<210>  20
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 Binding Domain LCDR1

<400>  20

Gln Asn Ile Asn Asn Tyr 
1               5       


<210>  21
<211>  3
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 Binding Domain LCDR2

<400>  21

Asn Thr Asn 
1           


<210>  22
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 Binding Domain LCDR3

<400>  22

Leu Gln His Asn Ser Gly Tyr Thr 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 binding domain HCDR1

<400>  23

Gly Phe Thr Phe Ser Asn Tyr Ala 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 binding domain HCDR2

<400>  24

Ile Asn Ser Gly Gly Gly Asp Ser 
1               5               


<210>  25
<211>  12
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 binding domain HCDR3

<400>  25

Ala Thr His Asn Tyr Gly Ser Thr Ile Phe Asp Tyr 
1               5                   10          


<210>  26
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 binding domain HCDR1

<400>  26

Gly Phe Ser Leu Thr Ser His Gly 
1               5               


<210>  27
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 binding domain HCDR3

<400>  27

Ala Arg Gly Leu Ala Tyr 
1               5       


<210>  28
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 binding domain LCDR1

<400>  28

Glu Asp Ile Tyr Ser Asp 
1               5       


<210>  29
<211>  3
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 binding domain LCDR2

<400>  29

Asn Ala Asn 
1           


<210>  30
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 binding domain LCDR3

<400>  30

Gln Gln Tyr Asn Asn Tyr Pro Trp Thr 
1               5                   


<210>  31
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 binding domain HCDR3

<400>  31

Ala Arg Gly Met Asp Ala 
1               5       


<210>  32
<211>  3
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 binding domain LCDR2

<400>  32

Tyr Ala Asn 
1           


<210>  33
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 binding domain LCDR3

<400>  33

Gln Gln Tyr Asn Asn Tyr Pro Phe Thr 
1               5                   


<210>  34
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 binding domain HCDR2

<400>  34

Ile Ser Ser Gly Gly Gly Asp Thr 
1               5               


<210>  35
<211>  12
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 binding domain HCDR3

<400>  35

Ala Thr His Asn Tyr Glu Ser Thr Val Leu Ile Thr 
1               5                   10          


<210>  36
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 binding domain HCDR3

<400>  36

Ala Arg Gly Phe Glu Tyr 
1               5       


<210>  37
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 binding domain LCDR1

<400>  37

Gln Asn Val Gly Lys Asn 
1               5       


<210>  38
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 binding domain LCDR3

<400>  38

Leu Gln Tyr Asn Tyr Asn Pro Trp Thr 
1               5                   


<210>  39
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 binding domain HCDR2

<400>  39

Ile Asn Thr Ser Gly Gly Ser Thr 
1               5               


<210>  40
<211>  18
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 binding domain HCDR3

<400>  40

Ala Thr Ile Tyr Tyr His Asp Gly Ser Tyr Tyr Tyr Ala Gly Trp Phe 
1               5                   10                  15      


Ala Tyr 
        


<210>  41
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 binding domain LCDR1

<400>  41

Glu Ser Val Ser Thr Leu 
1               5       


<210>  42
<211>  3
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 binding domain LCDR2

<400>  42

Gly Ala Ser 
1           


<210>  43
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 binding domain LCDR3

<400>  43

Gln Gln Ser Trp Asn Gly Pro Trp Thr 
1               5                   


<210>  44
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 binding domain HCDR2

<400>  44

Ile Ser Ser Gly Arg Gly Asn Thr 
1               5               


<210>  45
<211>  12
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 binding domain HCDR3

<400>  45

Val Thr His Asn Tyr Glu Ser Thr Ile Phe Asp Tyr 
1               5                   10          


<210>  46
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 binding domain HCDR1

<400>  46

Gly Phe Ser Leu Ile Ser Tyr Gly 
1               5               


<210>  47
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 binding domain HCDR1

<400>  47

Arg Phe Thr Phe Ser Asn Tyr Ala 
1               5               


<210>  48
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 binding domain HCDR3

<400>  48

Ala Arg Gly Phe Glu His 
1               5       


<210>  49
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 binding domain LCDR1

<400>  49

Glu Asp Ile Ser Asn Asp 
1               5       


<210>  50
<211>  3
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 binding domain LCDR2

<400>  50

Ala Ala Ser 
1           


<210>  51
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 binding domain LCDR3

<400>  51

Gln Gln Ser Tyr Lys Tyr Pro Leu Thr 
1               5                   


<210>  52
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 binding domain HCDR2

<400>  52

Ile Ser Asn Gly Gly Gly Asn Thr 
1               5               


<210>  53
<211>  12
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 binding domain HCDR3

<400>  53

Val Ala His Asn Tyr Glu Ser Thr Val Phe Asp Tyr 
1               5                   10          


<210>  54
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 binding domain HCDR2

<400>  54

Ile Ile Thr Gly Val Gly Asn Thr 
1               5               


<210>  55
<211>  12
<212>  PRT
<213>  Unknown

<220>
<223>  CD160 binding domain HCDR3

<400>  55

Glu His Ile Thr Thr Ser Pro Pro Phe Leu Ile Thr 
1               5                   10          


<210>  56
<211>  112
<212>  PRT
<213>  Unknown

<220>
<223>  VH

<400>  56

Gln Val Asn Leu Gln Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val Tyr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Trp Asn Asp Gly Gly Thr Asp Tyr Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Leu Gln Thr Glu Asp Thr Ala Ile Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Trp Thr His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  57
<211>  107
<212>  PRT
<213>  Unknown

<220>
<223>  VL

<400>  57

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Thr Val Ser Ile Glu Cys Leu Ala Ser Glu Asp Ile Tyr Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Leu Gln Asp Ser Glu Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  58
<211>  119
<212>  PRT
<213>  Unknown

<220>
<223>  VH

<400>  58

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Pro Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ala Trp Val Arg Gln Ala Pro Lys Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Thr Gly Asp Asp Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Gln Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Thr His Asn Tyr Glu Ser Thr Ile Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Val Met Val Thr Val Ser Ser 
        115                 


<210>  59
<211>  107
<212>  PRT
<213>  Unknown

<220>
<223>  VL

<400>  59

Asp Ile Ala Ile Thr Gln Ser Pro Ala Ser Met Thr Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ala Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Glu Thr Ser Lys Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Asn Asn Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Tyr Pro Ser Met Tyr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  60
<211>  119
<212>  PRT
<213>  Unknown

<220>
<223>  VH

<400>  60

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Phe Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ala Trp Val Arg Gln Ala Pro Lys Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Gly Arg Gly Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Gln Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Thr His Asn Tyr Glu Ser Thr Ile Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Val Met Val Thr Val Ser Ser 
        115                 


<210>  61
<211>  107
<212>  PRT
<213>  Unknown

<220>
<223>  VL

<400>  61

Glu Ile Val Leu Thr Gln Ser Pro Thr Thr Met Thr Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Ile Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ala Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Glu Thr Ser Lys Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Phe Asn Asn Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Tyr Pro Ser Met Tyr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  62
<211>  235
<212>  PRT
<213>  Unknown

<220>
<223>  scFv sequence

<400>  62

Gln Val Asn Leu Gln Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val Tyr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Trp Asn Asp Gly Gly Thr Asp Tyr Asn Pro Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Leu Gln Thr Glu Asp Thr Ala Ile Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Trp Thr His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        115                 120                 125             


Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Gly Glu 
    130                 135                 140                 


Thr Val Ser Ile Glu Cys Leu Ala Ser Glu Asp Ile Tyr Asn Asn Leu 
145                 150                 155                 160 


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile Tyr 
                165                 170                 175     


Tyr Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Glu Ser Glu 
        195                 200                 205             


Asp Val Ala Thr Tyr Phe Cys Leu Gln Asp Ser Glu Tyr Pro Pro Thr 
    210                 215                 220                 


Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg 
225                 230                 235 


<210>  63
<211>  242
<212>  PRT
<213>  Unknown

<220>
<223>  scFv sequence

<400>  63

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Pro Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ala Trp Val Arg Gln Ala Pro Lys Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Thr Gly Asp Asp Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Gln Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Thr His Asn Tyr Glu Ser Thr Ile Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Val Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Ala Ile Thr Gln Ser Pro Ala Ser 
    130                 135                 140                 


Met Thr Ala Ser Pro Gly Glu Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ala Ser 
                165                 170                 175     


Pro Lys Pro Trp Ile Tyr Glu Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
        195                 200                 205             


Asn Asn Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Asn Tyr Pro Ser Met Tyr Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
225                 230                 235                 240 


Lys Arg 
        


<210>  64
<211>  242
<212>  PRT
<213>  Unknown

<220>
<223>  scFv sequence

<400>  64

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Phe Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ala Trp Val Arg Gln Ala Pro Lys Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Gly Arg Gly Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Gln Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Thr His Asn Tyr Glu Ser Thr Ile Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Val Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Thr Thr 
    130                 135                 140                 


Met Thr Ala Ser Pro Gly Glu Lys Val Thr Ile Ile Cys Arg Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ala Ser 
                165                 170                 175     


Pro Lys Pro Trp Ile Tyr Glu Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Phe 
        195                 200                 205             


Asn Asn Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Asn Tyr Pro Ser Met Tyr Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
225                 230                 235                 240 


Lys Arg 
        


<210>  65
<211>  21
<212>  PRT
<213>  Unknown

<220>
<223>  CD8a transmembrane domain

<400>  65

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210>  66
<211>  27
<212>  PRT
<213>  Unknown

<220>
<223>  CD28 transmembrane domain

<400>  66

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  67
<211>  39
<212>  PRT
<213>  Unknown

<220>
<223>  CD28 endodomain

<400>  67

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr 
        35                  


<210>  68
<211>  37
<212>  PRT
<213>  Unknown

<220>
<223>  OX40 endodomain

<400>  68

Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
1               5                   10                  15      


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            20                  25                  30          


Thr Leu Ala Lys Ile 
        35          


<210>  69
<211>  42
<212>  PRT
<213>  Unknown

<220>
<223>  41-BB endodomain

<400>  69

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  70
<211>  114
<212>  PRT
<213>  Unknown

<220>
<223>  CD3 zeta endodomain

<400>  70

Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
1               5                   10                  15      


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
            20                  25                  30          


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
        35                  40                  45              


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    50                  55                  60                  


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
65                  70                  75                  80  


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                85                  90                  95      


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            100                 105                 110         


Pro Arg 
        


<210>  71
<211>  153
<212>  PRT
<213>  Unknown

<220>
<223>  CD28Z

<400>  71

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
        35                  40                  45              


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
    50                  55                  60                  


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
65                  70                  75                  80  


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
                85                  90                  95      


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
            100                 105                 110         


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
        115                 120                 125             


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
    130                 135                 140                 


Leu His Met Gln Ala Leu Pro Pro Arg 
145                 150             


<210>  72
<211>  189
<212>  PRT
<213>  Unknown

<220>
<223>  CD28OXZ

<400>  72

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Asp Gln Arg Leu Pro Pro 
        35                  40                  45              


Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln 
    50                  55                  60                  


Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Arg Val Lys 
65                  70                  75                  80  


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
                85                  90                  95      


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            100                 105                 110         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        115                 120                 125             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    130                 135                 140                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
145                 150                 155                 160 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                165                 170                 175     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            180                 185                 


<210>  73
<211>  20
<212>  PRT
<213>  Unknown

<220>
<223>  signal peptide

<400>  73

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  74
<211>  234
<212>  PRT
<213>  Unknown

<220>
<223>  hinge-CH2CH3 of human IgG1

<400>  74

Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Lys Asp 
225                 230                 


<210>  75
<211>  46
<212>  PRT
<213>  Unknown

<220>
<223>  human CD8 stalk

<400>  75

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        35                  40                  45      


<210>  76
<211>  20
<212>  PRT
<213>  Unknown

<220>
<223>  human IgG1 hinge

<400>  76

Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Lys Asp Pro Lys 
            20  


<210>  77
<211>  237
<212>  PRT
<213>  Unknown

<220>
<223>  IgG1 Hinge-Fc

<400>  77

Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Lys Asp Pro Lys 
225                 230                 235         


<210>  78
<211>  236
<212>  PRT
<213>  Unknown

<220>
<223>  IgG1 Hinge - Fc modified to remove Fc receptor recognition motifs

<400>  78

Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Lys Asp Pro Lys 
225                 230                 235     


<210>  79
<211>  520
<212>  PRT
<213>  Unknown

<220>
<223>  CAR sequence

<400>  79

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Val Trp Ile Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Asn Leu Gln Glu Ser Gly Pro Gly Leu Val 
            20                  25                  30          


Gln Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser 
        35                  40                  45              


Leu Thr Ser Tyr Gly Val Tyr Trp Val Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Met Gly Arg Ile Trp Asn Asp Gly Gly Thr Asp Tyr Asn 
65                  70                  75                  80  


Pro Ala Leu Lys Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser 
                85                  90                  95      


Gln Val Phe Leu Lys Leu Asn Ser Leu Gln Thr Glu Asp Thr Ala Ile 
            100                 105                 110         


Tyr Phe Cys Ala Arg Gly Trp Thr His Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Leu Gly Glu Thr Val Ser Ile Glu Cys Leu Ala Ser Glu Asp Ile 
                165                 170                 175     


Tyr Asn Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln 
            180                 185                 190         


Leu Leu Ile Tyr Tyr Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser 
    210                 215                 220                 


Leu Glu Ser Glu Asp Val Ala Thr Tyr Phe Cys Leu Gln Asp Ser Glu 
225                 230                 235                 240 


Tyr Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg Ser 
                245                 250                 255     


Asp Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
            260                 265                 270         


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
        275                 280                 285             


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
    290                 295                 300                 


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
305                 310                 315                 320 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
                325                 330                 335     


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
            340                 345                 350         


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
        355                 360                 365             


Ala Tyr Arg Ser Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro 
    370                 375                 380                 


Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp 
385                 390                 395                 400 


Ala His Ser Thr Leu Ala Lys Ile Arg Val Lys Phe Ser Arg Ser Ala 
                405                 410                 415     


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
            420                 425                 430         


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
        435                 440                 445             


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
    450                 455                 460                 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
465                 470                 475                 480 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                485                 490                 495     


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
            500                 505                 510         


His Met Gln Ala Leu Pro Pro Arg 
        515                 520 


<210>  80
<211>  488
<212>  PRT
<213>  Unknown

<220>
<223>  CAR sequence

<400>  80

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Arg Pro Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Asn Tyr Gly Met Ala Trp Val Arg Gln Ala Pro Lys Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Thr Ile Ser Thr Gly Asp Asp Asn Thr Tyr Tyr 
65                  70                  75                  80  


Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Gln Tyr Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Thr His Asn Tyr Glu Ser Thr Ile Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Val Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Ala Ile Thr Gln 
145                 150                 155                 160 


Ser Pro Ala Ser Met Thr Ala Ser Pro Gly Glu Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys 
            180                 185                 190         


Pro Gly Ala Ser Pro Lys Pro Trp Ile Tyr Glu Thr Ser Lys Leu Ala 
        195                 200                 205             


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
    210                 215                 220                 


Ser Leu Thr Ile Asn Asn Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
225                 230                 235                 240 


Cys Gln Gln Trp Asn Tyr Pro Ser Met Tyr Thr Phe Gly Ala Gly Thr 
                245                 250                 255     


Lys Leu Glu Leu Lys Arg Ser Asp Pro Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg 
                485             


<210>  81
<211>  488
<212>  PRT
<213>  Unknown

<220>
<223>  CAR sequence

<400>  81

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Phe Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Asn Tyr Gly Met Ala Trp Val Arg Gln Ala Pro Lys Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Ser Ile Ser Ser Gly Arg Gly Asn Thr Tyr Tyr 
65                  70                  75                  80  


Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Gln Tyr Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Val Thr His Asn Tyr Glu Ser Thr Ile Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Val Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln 
145                 150                 155                 160 


Ser Pro Thr Thr Met Thr Ala Ser Pro Gly Glu Lys Val Thr Ile Ile 
                165                 170                 175     


Cys Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys 
            180                 185                 190         


Pro Gly Ala Ser Pro Lys Pro Trp Ile Tyr Glu Thr Ser Lys Leu Ala 
        195                 200                 205             


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
    210                 215                 220                 


Ser Leu Thr Phe Asn Asn Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
225                 230                 235                 240 


Cys Gln Gln Trp Asn Tyr Pro Ser Met Tyr Thr Phe Gly Ala Gly Thr 
                245                 250                 255     


Lys Leu Glu Leu Lys Arg Ser Asp Pro Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg 
                485             


<210>  82
<211>  402
<212>  PRT
<213>  Unknown

<220>
<223>  iCasp9 sequence

<400>  82

Met Leu Glu Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
1               5                   10                  15      


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
            20                  25                  30          


Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro 
        35                  40                  45              


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
    50                  55                  60                  


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
65                  70                  75                  80  


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
                85                  90                  95      


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Gly 
            100                 105                 110         


Gly Gly Ser Gly Val Asp Gly Phe Gly Asp Val Gly Ala Leu Glu Ser 
        115                 120                 125             


Leu Arg Gly Asn Ala Asp Leu Ala Tyr Ile Leu Ser Met Glu Pro Cys 
    130                 135                 140                 


Gly His Cys Leu Ile Ile Asn Asn Val Asn Phe Cys Arg Glu Ser Gly 
145                 150                 155                 160 


Leu Arg Thr Arg Thr Gly Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg 
                165                 170                 175     


Arg Phe Ser Ser Leu His Phe Met Val Glu Val Lys Gly Asp Leu Thr 
            180                 185                 190         


Ala Lys Lys Met Val Leu Ala Leu Leu Glu Leu Ala Gln Gln Asp His 
        195                 200                 205             


Gly Ala Leu Asp Cys Cys Val Val Val Ile Leu Ser His Gly Cys Gln 
    210                 215                 220                 


Ala Ser His Leu Gln Phe Pro Gly Ala Val Tyr Gly Thr Asp Gly Cys 
225                 230                 235                 240 


Pro Val Ser Val Glu Lys Ile Val Asn Ile Phe Asn Gly Thr Ser Cys 
                245                 250                 255     


Pro Ser Leu Gly Gly Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Gly 
            260                 265                 270         


Gly Glu Gln Lys Asp His Gly Phe Glu Val Ala Ser Thr Ser Pro Glu 
        275                 280                 285             


Asp Glu Ser Pro Gly Ser Asn Pro Glu Pro Asp Ala Thr Pro Phe Gln 
    290                 295                 300                 


Glu Gly Leu Arg Thr Phe Asp Gln Leu Asp Ala Ile Ser Ser Leu Pro 
305                 310                 315                 320 


Thr Pro Ser Asp Ile Phe Val Ser Tyr Ser Thr Phe Pro Gly Phe Val 
                325                 330                 335     


Ser Trp Arg Asp Pro Lys Ser Gly Ser Trp Tyr Val Glu Thr Leu Asp 
            340                 345                 350         


Asp Ile Phe Glu Gln Trp Ala His Ser Glu Asp Leu Gln Ser Leu Leu 
        355                 360                 365             


Leu Arg Val Ala Asn Ala Val Ser Val Lys Gly Ile Tyr Lys Gln Met 
    370                 375                 380                 


Pro Gly Cys Phe Asn Phe Leu Arg Lys Lys Leu Phe Phe Lys Thr Ser 
385                 390                 395                 400 


Ala Ser 
        


<210>  83
<211>  157
<212>  PRT
<213>  Unknown

<220>
<223>  RQR8 sequence

<400>  83

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Ala Cys Pro Tyr Ser Asn Pro Ser Leu Cys Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser 
        35                  40                  45              


Thr Asn Val Ser Pro Ala Lys Pro Thr Thr Thr Ala Cys Pro Tyr Ser 
    50                  55                  60                  


Asn Pro Ser Leu Cys Ser Gly Gly Gly Gly Ser Pro Ala Pro Arg Pro 
65                  70                  75                  80  


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
                85                  90                  95      


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
            100                 105                 110         


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
        115                 120                 125             


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg 
    130                 135                 140                 


Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val 
145                 150                 155         


<210>  84
<211>  13
<212>  PRT
<213>  Unknown

<220>
<223>  Heavy chain CDR1

<400>  84

Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His 
1               5                   10              


<210>  85
<211>  16
<212>  PRT
<213>  Unknown

<220>
<223>  Heavy chain CDR2

<400>  85

Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp 
1               5                   10                  15      


<210>  86
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  Heavy chain CDR3

<400>  86

Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr 
1               5                   10  


<210>  87
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  Light chain CDR1

<400>  87

Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
1               5                   10  


<210>  88
<211>  11
<212>  PRT
<213>  Unknown

<220>
<223>  Light chain CDR2

<400>  88

Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser 
1               5                   10      


<210>  89
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  Light chain CDR3

<400>  89

Gln Gln Trp Ser Ser Asn Pro Phe Thr 
1               5                   


<210>  90
<211>  242
<212>  PRT
<213>  Unknown

<220>
<223>  scFv sequence

<400>  90

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala 
145                 150                 155                 160 


Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr 
                165                 170                 175     


Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val 
            180                 185                 190         


Pro Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr 
        195                 200                 205             


Ile Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Asn Arg 
        


<210>  91
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  Heavy chain CDR1

<400>  91

Gly Tyr Ser Phe Thr Gly Tyr Thr 
1               5               


<210>  92
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  Heavy chain CDR2

<400>  92

Ile Asn Pro Tyr Lys Gly Val Ser 
1               5               


<210>  93
<211>  15
<212>  PRT
<213>  Unknown

<220>
<223>  Heavy chain CDR3

<400>  93

Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val 
1               5                   10                  15  


<210>  94
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Light chain CDR1

<400>  94

Gln Asp Ile Arg Asn Tyr 
1               5       


<210>  95
<211>  3
<212>  PRT
<213>  Unknown

<220>
<223>  Light chain CDR2

<400>  95

Tyr Thr Ser 
1           


<210>  96
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  Light chain CDR3

<400>  96

Gln Gln Gly Asn Thr Leu Pro Trp Thr 
1               5                   


<210>  97
<211>  245
<212>  PRT
<213>  Unknown

<220>
<223>  scFv sequence

<400>  97

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asn Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro 
                165                 170                 175     


Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr 
            180                 185                 190         


Ile Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr 
    210                 215                 220                 


Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210>  98
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  Heavy chain CDR1

<400>  98

Gly Phe Thr Phe Ser Ser Phe Pro 
1               5               


<210>  99
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  Heavy chain CDR2

<400>  99

Ile Ser Thr Ser Gly Gly Arg Thr 
1               5               


<210>  100
<211>  12
<212>  PRT
<213>  Unknown

<220>
<223>  Heavy chain CDR3

<400>  100

Ala Lys Phe Arg Gln Tyr Ser Gly Gly Phe Asp Tyr 
1               5                   10          


<210>  101
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  Light chain CDR1

<400>  101

Ser Gly Asn Ile Glu Asn Asn Tyr 
1               5               


<210>  102
<211>  3
<212>  PRT
<213>  Unknown

<220>
<223>  Light chain CDR2

<400>  102

Asp Asp Asp 
1           


<210>  103
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  Light chain CDR3

<400>  103

His Ser Tyr Val Ser Ser Phe Asn Val 
1               5                   


<210>  104
<211>  245
<212>  PRT
<213>  Unknown

<220>
<223>  scFv sequence

<400>  104

Asp Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Ile Ile Ser Cys Thr Leu Ser Ser Gly Asn Ile Glu Asn Asn 
            20                  25                  30          


Tyr Val His Trp Tyr Gln Gln Arg Pro Gly Arg Ala Pro Thr Thr Val 
        35                  40                  45              


Ile Phe Asp Asp Asp Lys Arg Pro Asp Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Arg Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Gln Thr Glu Asp Glu Ala Asp Tyr Tyr Cys His Ser Tyr Val Ser 
                85                  90                  95      


Ser Phe Asn Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Pro Met 
145                 150                 155                 160 


Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Ser Thr Ser Gly Gly Arg Thr Tyr Tyr Arg Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Phe Arg Gln Tyr Ser Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210>  105
<211>  20
<212>  PRT
<213>  Unknown

<220>
<223>  Signal peptide

<400>  105

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  106
<211>  21
<212>  PRT
<213>  Unknown

<220>
<223>  Signal peptide

<400>  106

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Gly 
            20      


<210>  107
<211>  26
<212>  PRT
<213>  Unknown

<220>
<223>  IgG1 hinge

<400>  107

Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Lys Asp Pro Lys Ser Gly Gly Gly Gly Ser 
            20                  25      


<210>  108
<211>  45
<212>  PRT
<213>  Unknown

<220>
<223>  CD8 stalk

<400>  108

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  109
<211>  7
<212>  PRT
<213>  Unknown

<220>
<223>  Spacer

<400>  109

Ser Gly Gly Gly Ser Asp Pro 
1               5           


<210>  110
<211>  554
<212>  PRT
<213>  Unknown

<220>
<223>  bi-specific molecule

<400>  110

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Val Trp Ile Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Asn Leu Gln Glu Ser Gly Pro Gly Leu Val 
            20                  25                  30          


Gln Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser 
        35                  40                  45              


Leu Thr Ser Tyr Gly Val Tyr Trp Val Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Met Gly Arg Ile Trp Asn Asp Gly Gly Thr Asp Tyr Asn 
65                  70                  75                  80  


Pro Ala Leu Lys Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser 
                85                  90                  95      


Gln Val Phe Leu Lys Leu Asn Ser Leu Gln Thr Glu Asp Thr Ala Ile 
            100                 105                 110         


Tyr Phe Cys Ala Arg Gly Trp Thr His Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala 
145                 150                 155                 160 


Ser Leu Gly Glu Thr Val Ser Ile Glu Cys Leu Ala Ser Glu Asp Ile 
                165                 170                 175     


Tyr Asn Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln 
            180                 185                 190         


Leu Leu Ile Tyr Tyr Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser 
    210                 215                 220                 


Leu Glu Ser Glu Asp Val Ala Thr Tyr Phe Cys Leu Gln Asp Ser Glu 
225                 230                 235                 240 


Tyr Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg Ser 
                245                 250                 255     


Asp Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
            260                 265                 270         


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
        275                 280                 285             


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ser 
    290                 295                 300                 


Gly Gly Gly Gly Ser Asp Phe Met Leu Thr Gln Pro His Ser Val Ser 
305                 310                 315                 320 


Glu Ser Pro Gly Lys Thr Val Ile Ile Ser Cys Thr Leu Ser Ser Gly 
                325                 330                 335     


Asn Ile Glu Asn Asn Tyr Val His Trp Tyr Gln Gln Arg Pro Gly Arg 
            340                 345                 350         


Ala Pro Thr Thr Val Ile Phe Asp Asp Asp Lys Arg Pro Asp Gly Val 
        355                 360                 365             


Pro Asp Arg Phe Ser Gly Ser Ile Asp Arg Ser Ser Asn Ser Ala Ser 
    370                 375                 380                 


Leu Thr Ile Ser Gly Leu Gln Thr Glu Asp Glu Ala Asp Tyr Tyr Cys 
385                 390                 395                 400 


His Ser Tyr Val Ser Ser Phe Asn Val Phe Gly Gly Gly Thr Lys Leu 
                405                 410                 415     


Thr Val Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            420                 425                 430         


Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
        435                 440                 445             


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
    450                 455                 460                 


Ser Ser Phe Pro Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
465                 470                 475                 480 


Glu Trp Val Ser Thr Ile Ser Thr Ser Gly Gly Arg Thr Tyr Tyr Arg 
                485                 490                 495     


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
            500                 505                 510         


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
        515                 520                 525             


Tyr Tyr Cys Ala Lys Phe Arg Gln Tyr Ser Gly Gly Phe Asp Tyr Trp 
    530                 535                 540                 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
545                 550                 


<210>  111
<211>  561
<212>  PRT
<213>  Unknown

<220>
<223>  bi-specific molecule

<400>  111

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Val Trp Ile Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Arg Pro Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Asn Tyr Gly Met Ala Trp Val Arg Gln Ala Pro Lys Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Thr Ile Ser Thr Gly Asp Asp Asn Thr Tyr Tyr 
65                  70                  75                  80  


Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Gln Tyr Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Thr His Asn Tyr Glu Ser Thr Ile Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Val Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Ala Ile Thr Gln 
145                 150                 155                 160 


Ser Pro Ala Ser Met Thr Ala Ser Pro Gly Glu Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys 
            180                 185                 190         


Pro Gly Ala Ser Pro Lys Pro Trp Ile Tyr Glu Thr Ser Lys Leu Ala 
        195                 200                 205             


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
    210                 215                 220                 


Ser Leu Thr Ile Asn Asn Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
225                 230                 235                 240 


Cys Gln Gln Trp Asn Tyr Pro Ser Met Tyr Thr Phe Gly Ala Gly Thr 
                245                 250                 255     


Lys Leu Glu Leu Lys Arg Ser Asp Pro Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ser Gly Gly Gly Gly Ser Asp Phe Met Leu 
305                 310                 315                 320 


Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys Thr Val Ile Ile 
                325                 330                 335     


Ser Cys Thr Leu Ser Ser Gly Asn Ile Glu Asn Asn Tyr Val His Trp 
            340                 345                 350         


Tyr Gln Gln Arg Pro Gly Arg Ala Pro Thr Thr Val Ile Phe Asp Asp 
        355                 360                 365             


Asp Lys Arg Pro Asp Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp 
    370                 375                 380                 


Arg Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Gln Thr Glu 
385                 390                 395                 400 


Asp Glu Ala Asp Tyr Tyr Cys His Ser Tyr Val Ser Ser Phe Asn Val 
                405                 410                 415     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu 
        435                 440                 445             


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    450                 455                 460                 


Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Pro Met Ala Trp Val Arg 
465                 470                 475                 480 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr Ile Ser Thr Ser 
                485                 490                 495     


Gly Gly Arg Thr Tyr Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile 
            500                 505                 510         


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        515                 520                 525             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Phe Arg Gln Tyr 
    530                 535                 540                 


Ser Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
545                 550                 555                 560 


Ser 
    


<210>  112
<211>  561
<212>  PRT
<213>  Unknown

<220>
<223>  bi-specific molecule

<400>  112

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Val Trp Ile Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Phe Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Asn Tyr Gly Met Ala Trp Val Arg Gln Ala Pro Lys Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Ser Ile Ser Ser Gly Arg Gly Asn Thr Tyr Tyr 
65                  70                  75                  80  


Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Gln Tyr Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Val Thr His Asn Tyr Glu Ser Thr Ile Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Val Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln 
145                 150                 155                 160 


Ser Pro Thr Thr Met Thr Ala Ser Pro Gly Glu Lys Val Thr Ile Ile 
                165                 170                 175     


Cys Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys 
            180                 185                 190         


Pro Gly Ala Ser Pro Lys Pro Trp Ile Tyr Glu Thr Ser Lys Leu Ala 
        195                 200                 205             


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
    210                 215                 220                 


Ser Leu Thr Phe Asn Asn Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
225                 230                 235                 240 


Cys Gln Gln Trp Asn Tyr Pro Ser Met Tyr Thr Phe Gly Ala Gly Thr 
                245                 250                 255     


Lys Leu Glu Leu Lys Arg Ser Asp Pro Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ser Gly Gly Gly Gly Ser Asp Phe Met Leu 
305                 310                 315                 320 


Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys Thr Val Ile Ile 
                325                 330                 335     


Ser Cys Thr Leu Ser Ser Gly Asn Ile Glu Asn Asn Tyr Val His Trp 
            340                 345                 350         


Tyr Gln Gln Arg Pro Gly Arg Ala Pro Thr Thr Val Ile Phe Asp Asp 
        355                 360                 365             


Asp Lys Arg Pro Asp Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp 
    370                 375                 380                 


Arg Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Gln Thr Glu 
385                 390                 395                 400 


Asp Glu Ala Asp Tyr Tyr Cys His Ser Tyr Val Ser Ser Phe Asn Val 
                405                 410                 415     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu 
        435                 440                 445             


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    450                 455                 460                 


Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Pro Met Ala Trp Val Arg 
465                 470                 475                 480 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr Ile Ser Thr Ser 
                485                 490                 495     


Gly Gly Arg Thr Tyr Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile 
            500                 505                 510         


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        515                 520                 525             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Phe Arg Gln Tyr 
    530                 535                 540                 


Ser Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
545                 550                 555                 560 


Ser 
    


<210>  113
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  linker

<400>  113

Ser Gly Gly Gly Gly Ser 
1               5       


<210>  114
<211>  119
<212>  PRT
<213>  Unknown

<220>
<223>  VH

<400>  114

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Val Asn Ser Gly Gly Ala Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Gln Tyr 
65                  70                  75                  80  


Leu His Ile Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Thr His Asn Tyr Glu Ser Thr Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ala Met Val Thr Val Ser Ser 
        115                 


<210>  115
<211>  107
<212>  PRT
<213>  Unknown

<220>
<223>  VL

<400>  115

Glu Ile Val Leu Thr Gln Ser Pro Thr Thr Met Thr Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ala Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Glu Thr Ser Lys Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Asn Asn Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Tyr Pro Ser Met Tyr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  116
<211>  119
<212>  PRT
<213>  Unknown

<220>
<223>  VH

<400>  116

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Val Ser Asn Gly Gly Gly Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Gln Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Thr His Asn Tyr Glu Ser Thr Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ala Met Val Thr Val Ser Ser 
        115                 


<210>  117
<211>  107
<212>  PRT
<213>  Unknown

<220>
<223>  VL

<400>  117

Glu Ile Val Leu Thr Gln Ser Pro Thr Thr Met Thr Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ala Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Glu Thr Ser Lys Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Asn Asn Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Tyr Pro Ser Met Tyr 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  118
<211>  112
<212>  PRT
<213>  Unknown

<220>
<223>  VH

<400>  118

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Ile Asn Trp Phe Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Trp Asn Asp Gly Gly Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Ile Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Met Glu Ala Trp Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
            100                 105                 110         


<210>  119
<211>  106
<212>  PRT
<213>  Unknown

<220>
<223>  VL

<400>  119

Asp Ile Gln Leu Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Lys Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Leu Gln His Asn Ser Gly Tyr Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  120
<211>  119
<212>  PRT
<213>  Unknown

<220>
<223>  VH

<400>  120

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Phe Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asn Ser Gly Gly Gly Asp Ser Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Gln Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Thr His Asn Tyr Gly Ser Thr Ile Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ala Met Val Thr Val Ser Ser 
        115                 


<210>  121
<211>  107
<212>  PRT
<213>  Unknown

<220>
<223>  VL

<400>  121

Glu Ile Ile Leu Thr Gln Ser Pro Thr Thr Met Thr Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ala Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Glu Thr Ser Lys Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Asn Asn Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Tyr Pro Ser Met Tyr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  122
<211>  112
<212>  PRT
<213>  Unknown

<220>
<223>  VH

<400>  122

Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser His 
            20                  25                  30          


Gly Val Asn Trp Phe Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Trp Asn Asp Gly Gly Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ile Arg Asp Thr Ser Lys Gly Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Ile Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  123
<211>  107
<212>  PRT
<213>  Unknown

<220>
<223>  VL

<400>  123

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Thr Val Asn Ile Glu Cys Leu Ala Ser Glu Asp Ile Tyr Ser Asp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Ser Leu Gln Asn Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Tyr Asn Asn Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  124
<211>  112
<212>  PRT
<213>  Unknown

<220>
<223>  VH

<400>  124

Gln Val Asn Leu Gln Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Ile Asn Trp Phe Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Trp Asn Asp Gly Gly Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Ile Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Met Asp Ala Trp Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
            100                 105                 110         


<210>  125
<211>  107
<212>  PRT
<213>  Unknown

<220>
<223>  VL

<400>  125

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Thr Val Ser Ile Glu Cys Leu Ala Ser Glu Asp Ile Tyr Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Asn Ser Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Tyr Asn Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  126
<211>  119
<212>  PRT
<213>  Unknown

<220>
<223>  VH

<400>  126

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Gly Gly Gly Asp Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Gln Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Thr His Asn Tyr Glu Ser Thr Val Leu Ile Thr Trp Gly Gln Gly 
            100                 105                 110         


Ala Ser Val Thr Val Ser Ser 
        115                 


<210>  127
<211>  107
<212>  PRT
<213>  Unknown

<220>
<223>  VL

<400>  127

Glu Ile Val Leu Thr Gln Ser Pro Thr Thr Thr Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ala Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Glu Thr Ser Lys Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Asn Asn Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Tyr Pro Ser Met Tyr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  128
<211>  112
<212>  PRT
<213>  Unknown

<220>
<223>  VH

<400>  128

Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val Asn Trp Phe Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Trp Asn Asp Gly Gly Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Ile Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Phe Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  129
<211>  107
<212>  PRT
<213>  Unknown

<220>
<223>  VL

<400>  129

Asp Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Ile Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Asn Cys Lys Ala Ser Gln Asn Val Gly Lys Asn 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Asn Met Gln Thr 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Leu Gln Tyr Asn Tyr Asn Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  130
<211>  125
<212>  PRT
<213>  Unknown

<220>
<223>  VH

<400>  130

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asn Thr Ser Gly Gly Ser Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ile Tyr Tyr His Asp Gly Ser Tyr Tyr Tyr Ala Gly Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  131
<211>  106
<212>  PRT
<213>  Unknown

<220>
<223>  VL

<400>  131

Asp Ile Val Leu Thr Gln Ser Pro Ala Leu Ala Val Ser Pro Gly Glu 
1               5                   10                  15      


Arg Val Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Ser Thr Leu Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Leu Gly Gln Gln Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Gly Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile Asp Pro Val Glu Ala Asp 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Ser Trp Asn Gly Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  132
<211>  112
<212>  PRT
<213>  Unknown

<220>
<223>  VH

<400>  132

Gln Val Asn Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ile Ser Tyr 
            20                  25                  30          


Gly Val Asn Trp Phe Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Trp Asn Asp Gly Gly Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Ile Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Phe Glu His Trp Gly Gln Gly Val Met Val Thr Val Ser Ser 
            100                 105                 110         


<210>  133
<211>  107
<212>  PRT
<213>  Unknown

<220>
<223>  VL

<400>  133

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Thr Val Ser Ile Glu Cys Leu Thr Ser Glu Asp Ile Ser Asn Asp 
            20                  25                  30          


Ser Ala Trp Tyr Gln Gln Lys Ser Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Arg Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Tyr Ser Leu Lys Ile Ser Gly Met Gln Pro 
65                  70                  75                  80  


Glu Asp Glu Ala Asp Tyr Phe Cys Gln Gln Ser Tyr Lys Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  134
<211>  119
<212>  PRT
<213>  Unknown

<220>
<223>  VH

<400>  134

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Asn Gly Gly Gly Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Gln Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Ala His Asn Tyr Glu Ser Thr Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ala Met Val Thr Val Ser Ser 
        115                 


<210>  135
<211>  107
<212>  PRT
<213>  Unknown

<220>
<223>  VL

<400>  135

Glu Ile Val Leu Thr Gln Ser Pro Thr Pro Met Thr Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ala Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Glu Thr Ser Lys Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Asn Asn Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Tyr Pro Ser Met Tyr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  136
<211>  119
<212>  PRT
<213>  Unknown

<220>
<223>  VH

<400>  136

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Thr Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ile Thr Gly Val Gly Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Gln Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Glu His Ile Thr Thr Ser Pro Pro Phe Leu Ile Thr Trp Gly Gln Gly 
            100                 105                 110         


Ser Trp Ser Gln Ser Pro Gln 
        115                 


<210>  137
<211>  107
<212>  PRT
<213>  Unknown

<220>
<223>  VL

<400>  137

Glu Ile Val Leu Thr Gln Ser Pro Thr Thr Thr Thr Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ala Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Glu Thr Ser Lys Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Asn Asn Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Tyr Pro Ser Met Tyr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  138
<211>  119
<212>  PRT
<213>  Unknown

<220>
<223>  VH

<400>  138

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Arg Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Gly Ala Gly Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Gln Tyr 
65                  70                  75                  80  


Leu Gln Met Gly Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Thr His Asn Tyr Glu Ser Thr Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ala Ser Val Thr Val Ser Ser 
        115                 


<210>  139
<211>  107
<212>  PRT
<213>  Unknown

<220>
<223>  VL

<400>  139

Glu Thr Val Leu Thr Gln Ser Pro Thr Thr Thr Pro Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Ala Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Asn Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Asn Asn Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Tyr Pro Ser Met Tyr 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  140
<211>  112
<212>  PRT
<213>  Unknown

<220>
<223>  VH

<400>  140

Gln Val Asn Leu Gln Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Ile Asn Trp Phe Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Trp Asn Asp Gly Gly Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Ile Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Met Glu Ala Trp Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
            100                 105                 110         


<210>  141
<211>  107
<212>  PRT
<213>  Unknown

<220>
<223>  VL

<400>  141

Asp Ile Arg Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Thr Val Ser Ile Glu Cys Leu Ala Ser Glu Asp Ile Tyr Lys Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Phe Cys Leu Gln Asp Ser Glu Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  142
<211>  119
<212>  PRT
<213>  Unknown

<220>
<223>  VH

<400>  142

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asn Ser Gly Gly Gly Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Gln Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Thr His Asn Tyr Glu Ser Thr Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Val Met Val Thr Val Ser Ser 
        115                 


<210>  143
<211>  107
<212>  PRT
<213>  Unknown

<220>
<223>  VL

<400>  143

Glu Ile Val Leu Thr Gln Ser Pro Thr Ser Met Thr Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ala Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Glu Thr Ser Lys Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Asn Asn Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Tyr Pro Ser Met Tyr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  144
<211>  119
<212>  PRT
<213>  Unknown

<220>
<223>  VH

<400>  144

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile His Ser Gly Gly Gly Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Gln Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Thr His Asn Tyr Glu Ser Thr Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ala Met Val Thr Val Ser Ser 
        115                 


<210>  145
<211>  107
<212>  PRT
<213>  Unknown

<220>
<223>  VL

<400>  145

Glu Ile Val Leu Thr Gln Ser Pro Thr Thr Met Thr Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ala Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Glu Thr Ser Lys Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Asn Asn Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Tyr Pro Ser Met Tyr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  146
<211>  119
<212>  PRT
<213>  Unknown

<220>
<223>  VH

<400>  146

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Asn Gly Gly Gly Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Gln Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Thr His Asn Tyr Glu Ser Thr Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ala Met Val Thr Val Ser Ser 
        115                 


<210>  147
<211>  3
<212>  PRT
<213>  Unknown

<220>
<223>  LCDR2

<400>  147

Asp Thr Ser 
1           


<210>  148
<211>  119
<212>  PRT
<213>  Unknown

<220>
<223>  VH

<400>  148

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Asn Gly Gly Gly Asn Ser Phe Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Gln Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Thr His Asn Tyr Glu Ser Thr Val Phe Asp Tyr Trp Gly Arg Gly 
            100                 105                 110         


Val Met Val Thr Val Ser Ser 
        115                 


<210>  149
<211>  107
<212>  PRT
<213>  Unknown

<220>
<223>  VL

<400>  149

Glu Ile Val Leu Thr Gln Ser Pro Thr Thr Met Thr Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ala Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Glu Thr Ser Lys Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Asn Asn Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Tyr Pro Ser Met Tyr 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  150
<211>  119
<212>  PRT
<213>  Unknown

<220>
<223>  VH

<400>  150

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Gly Ser Gly Gly Ser Asp Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Gln Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Thr His Asn Tyr Glu Ser Thr Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Val Met Val Thr Val Ser Ser 
        115                 


<210>  151
<211>  107
<212>  PRT
<213>  Unknown

<220>
<223>  VL

<400>  151

Asp Thr Val Leu Thr Gln Ser Pro Thr Ser Met Thr Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ala Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Glu Thr Ser Lys Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Asn Asn Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Tyr Pro Ser Met Tyr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  152
<211>  119
<212>  PRT
<213>  Unknown

<220>
<223>  VH

<400>  152

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asn Ser Gly Gly Gly Asp Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Gln Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Thr His Asn Tyr Glu Ser Thr Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Val Met Val Thr Val Ser Ser 
        115                 


<210>  153
<211>  107
<212>  PRT
<213>  Unknown

<220>
<223>  VL

<400>  153

Glu Ile Val Leu Thr Gln Ser Pro Thr Thr Met Thr Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ala Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Glu Thr Ser Lys Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Phe Asn Asn Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Tyr Pro Ser Met Tyr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  154
<211>  119
<212>  PRT
<213>  Unknown

<220>
<223>  VH

<400>  154

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Gly Gly Gly Asp Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Gln Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Thr His Asn Tyr Glu Ser Thr Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ala Ser Val Thr Val Ser Ser 
        115                 


<210>  155
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  LCDR1

<400>  155

Glu Asp Ile Tyr Lys Asn 
1               5       


<210>  156
<211>  119
<212>  PRT
<213>  Unknown

<220>
<223>  VH

<400>  156

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Gly Asn Tyr 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Val Asn Ser Gly Gly Gly Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Gln Tyr 
65                  70                  75                  80  


Leu His Ile Asp Gly Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Thr His Asn Tyr Glu Ser Thr Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ala Ser Val Thr Val Ser Ser 
        115                 


<210>  157
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  LCDR3

<400>  157

Leu Gln Asp Ser Glu Tyr Pro Leu Thr 
1               5                   


<210>  158
<211>  243
<212>  PRT
<213>  Unknown

<220>
<223>  scFv sequence

<400>  158

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Val Asn Ser Gly Gly Ala Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Gln Tyr 
65                  70                  75                  80  


Leu His Ile Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Thr His Asn Tyr Glu Ser Thr Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ala Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Thr 
    130                 135                 140                 


Thr Met Thr Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ala 
                165                 170                 175     


Ser Pro Lys Pro Trp Ile Tyr Glu Thr Ser Lys Leu Ala Ser Gly Val 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr 
        195                 200                 205             


Ile Asn Asn Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Trp Asn Tyr Pro Ser Met Tyr Thr Phe Gly Ala Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Leu Lys Arg 
            


<210>  159
<211>  242
<212>  PRT
<213>  Unknown

<220>
<223>  scFv sequence

<400>  159

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Val Ser Asn Gly Gly Gly Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Gln Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Thr His Asn Tyr Glu Ser Thr Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ala Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Thr Thr 
    130                 135                 140                 


Met Thr Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ala Ser 
                165                 170                 175     


Pro Lys Pro Trp Ile Tyr Glu Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
        195                 200                 205             


Asn Asn Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Asn Tyr Pro Ser Met Tyr Thr Phe Gly Pro Gly Thr Lys Leu Glu Leu 
225                 230                 235                 240 


Lys Arg 
        


<210>  160
<211>  234
<212>  PRT
<213>  Unknown

<220>
<223>  scFv sequence

<400>  160

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Ile Asn Trp Phe Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Trp Asn Asp Gly Gly Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Ile Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Met Glu Ala Trp Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        115                 120                 125             


Ile Gln Leu Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly Asp 
    130                 135                 140                 


Arg Val Thr Leu Ser Cys Lys Gly Ser Gln Asn Ile Asn Asn Tyr Leu 
145                 150                 155                 160 


Ala Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Leu Leu Ile Tyr 
                165                 170                 175     


Asn Thr Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
        195                 200                 205             


Asp Phe Ala Thr Tyr Phe Cys Leu Gln His Asn Ser Gly Tyr Thr Phe 
    210                 215                 220                 


Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg 
225                 230                 


<210>  161
<211>  242
<212>  PRT
<213>  Unknown

<220>
<223>  scFv sequence

<400>  161

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Phe Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asn Ser Gly Gly Gly Asp Ser Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Gln Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Thr His Asn Tyr Gly Ser Thr Ile Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ala Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Ile Ile Leu Thr Gln Ser Pro Thr Thr 
    130                 135                 140                 


Met Thr Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ala Ser 
                165                 170                 175     


Pro Lys Pro Trp Ile Tyr Glu Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
        195                 200                 205             


Asn Asn Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Asn Tyr Pro Ser Met Tyr Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
225                 230                 235                 240 


Lys Arg 
        


<210>  162
<211>  235
<212>  PRT
<213>  Unknown

<220>
<223>  scFv sequence

<400>  162

Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser His 
            20                  25                  30          


Gly Val Asn Trp Phe Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Trp Asn Asp Gly Gly Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ile Arg Asp Thr Ser Lys Gly Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Ile Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        115                 120                 125             


Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Gly Glu 
    130                 135                 140                 


Thr Val Asn Ile Glu Cys Leu Ala Ser Glu Asp Ile Tyr Ser Asp Leu 
145                 150                 155                 160 


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile Tyr 
                165                 170                 175     


Asn Ala Asn Ser Leu Gln Asn Gly Val Pro Ser Arg Phe Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser Glu 
        195                 200                 205             


Asp Val Ala Thr Tyr Phe Cys Gln Gln Tyr Asn Asn Tyr Pro Trp Thr 
    210                 215                 220                 


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
225                 230                 235 


<210>  163
<211>  235
<212>  PRT
<213>  Unknown

<220>
<223>  scFv sequence

<400>  163

Gln Val Asn Leu Gln Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Ile Asn Trp Phe Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Trp Asn Asp Gly Gly Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Ile Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Met Asp Ala Trp Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        115                 120                 125             


Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Gly Glu 
    130                 135                 140                 


Thr Val Ser Ile Glu Cys Leu Ala Ser Glu Asp Ile Tyr Asn Asn Leu 
145                 150                 155                 160 


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile Tyr 
                165                 170                 175     


Tyr Ala Asn Ser Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser Glu 
        195                 200                 205             


Asp Val Ala Thr Tyr Phe Cys Gln Gln Tyr Asn Asn Tyr Pro Phe Thr 
    210                 215                 220                 


Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys Arg 
225                 230                 235 


<210>  164
<211>  242
<212>  PRT
<213>  Unknown

<220>
<223>  scFv sequence

<400>  164

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Gly Gly Gly Asp Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Gln Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Thr His Asn Tyr Glu Ser Thr Val Leu Ile Thr Trp Gly Gln Gly 
            100                 105                 110         


Ala Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Thr Thr 
    130                 135                 140                 


Thr Ala Ala Ser Pro Gly Glu Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ala Ser 
                165                 170                 175     


Pro Lys Pro Trp Ile Tyr Glu Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
        195                 200                 205             


Asn Asn Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Asn Tyr Pro Ser Met Tyr Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Arg 
        


<210>  165
<211>  235
<212>  PRT
<213>  Unknown

<220>
<223>  scFv sequence

<400>  165

Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val Asn Trp Phe Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Trp Asn Asp Gly Gly Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Ile Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Phe Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        115                 120                 125             


Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Ile Ser Val Gly Asp 
    130                 135                 140                 


Arg Val Thr Met Asn Cys Lys Ala Ser Gln Asn Val Gly Lys Asn Ile 
145                 150                 155                 160 


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
                165                 170                 175     


Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly Ser 
            180                 185                 190         


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Asn Met Gln Thr Glu 
        195                 200                 205             


Asp Leu Ala Val Tyr Tyr Cys Leu Gln Tyr Asn Tyr Asn Pro Trp Thr 
    210                 215                 220                 


Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg 
225                 230                 235 


<210>  166
<211>  247
<212>  PRT
<213>  Unknown

<220>
<223>  scFv sequence

<400>  166

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asn Thr Ser Gly Gly Ser Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ile Tyr Tyr His Asp Gly Ser Tyr Tyr Tyr Ala Gly Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu 
    130                 135                 140                 


Thr Gln Ser Pro Ala Leu Ala Val Ser Pro Gly Glu Arg Val Ser Ile 
145                 150                 155                 160 


Ser Cys Arg Ala Ser Glu Ser Val Ser Thr Leu Met His Trp Tyr Gln 
                165                 170                 175     


Gln Lys Leu Gly Gln Gln Pro Lys Leu Leu Ile Tyr Gly Ala Ser Asn 
            180                 185                 190         


Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Asn Ile Asp Pro Val Glu Ala Asp Asp Ile Ala Thr 
    210                 215                 220                 


Tyr Phe Cys Gln Gln Ser Trp Asn Gly Pro Trp Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Leu Lys Arg 
                245         


<210>  167
<211>  235
<212>  PRT
<213>  Unknown

<220>
<223>  scFv sequence

<400>  167

Gln Val Asn Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ile Ser Tyr 
            20                  25                  30          


Gly Val Asn Trp Phe Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Trp Asn Asp Gly Gly Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Ile Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Phe Glu His Trp Gly Gln Gly Val Met Val Thr Val Ser Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        115                 120                 125             


Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Gly Glu 
    130                 135                 140                 


Thr Val Ser Ile Glu Cys Leu Thr Ser Glu Asp Ile Ser Asn Asp Ser 
145                 150                 155                 160 


Ala Trp Tyr Gln Gln Lys Ser Gly Lys Ser Pro Gln Leu Leu Ile Tyr 
                165                 170                 175     


Ala Ala Ser Arg Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Thr Arg Tyr Ser Leu Lys Ile Ser Gly Met Gln Pro Glu 
        195                 200                 205             


Asp Glu Ala Asp Tyr Phe Cys Gln Gln Ser Tyr Lys Tyr Pro Leu Thr 
    210                 215                 220                 


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
225                 230                 235 


<210>  168
<211>  242
<212>  PRT
<213>  Unknown

<220>
<223>  scFv sequence

<400>  168

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Asn Gly Gly Gly Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Gln Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Ala His Asn Tyr Glu Ser Thr Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ala Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Thr Pro 
    130                 135                 140                 


Met Thr Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ala Ser 
                165                 170                 175     


Pro Lys Pro Trp Ile Tyr Glu Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
        195                 200                 205             


Asn Asn Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Asn Tyr Pro Ser Met Tyr Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
225                 230                 235                 240 


Lys Arg 
        


<210>  169
<211>  242
<212>  PRT
<213>  Unknown

<220>
<223>  scFv sequence

<400>  169

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Thr Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ile Thr Gly Val Gly Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Gln Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Glu His Ile Thr Thr Ser Pro Pro Phe Leu Ile Thr Trp Gly Gln Gly 
            100                 105                 110         


Ser Trp Ser Gln Ser Pro Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Thr Thr 
    130                 135                 140                 


Thr Thr Ala Ser Pro Gly Glu Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ala Ser 
                165                 170                 175     


Pro Lys Pro Trp Ile Tyr Glu Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
        195                 200                 205             


Asn Asn Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Asn Tyr Pro Ser Met Tyr Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Arg 
        


<210>  170
<211>  242
<212>  PRT
<213>  Unknown

<220>
<223>  scFv sequence

<400>  170

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Arg Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Gly Ala Gly Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Gln Tyr 
65                  70                  75                  80  


Leu Gln Met Gly Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Thr His Asn Tyr Glu Ser Thr Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ala Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Thr Val Leu Thr Gln Ser Pro Thr Thr 
    130                 135                 140                 


Thr Pro Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Ala Ser 
                165                 170                 175     


Pro Lys Leu Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Asn Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
        195                 200                 205             


Asn Asn Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Asn Tyr Pro Ser Met Tyr Thr Phe Gly Pro Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Arg 
        


<210>  171
<211>  235
<212>  PRT
<213>  Unknown

<220>
<223>  scFv sequence

<400>  171

Gln Val Asn Leu Gln Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Ile Asn Trp Phe Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Trp Asn Asp Gly Gly Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Ile Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Met Glu Ala Trp Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        115                 120                 125             


Ile Arg Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Gly Glu 
    130                 135                 140                 


Thr Val Ser Ile Glu Cys Leu Ala Ser Glu Asp Ile Tyr Lys Asn Leu 
145                 150                 155                 160 


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile Tyr 
                165                 170                 175     


Tyr Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Glu Ser Glu 
        195                 200                 205             


Asp Ala Ala Thr Tyr Phe Cys Leu Gln Asp Ser Glu Tyr Pro Leu Thr 
    210                 215                 220                 


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
225                 230                 235 


<210>  172
<211>  242
<212>  PRT
<213>  Unknown

<220>
<223>  scFv sequence

<400>  172

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asn Ser Gly Gly Gly Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Gln Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Thr His Asn Tyr Glu Ser Thr Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Val Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Thr Ser 
    130                 135                 140                 


Met Thr Ala Ser Pro Gly Glu Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ala Ser 
                165                 170                 175     


Pro Lys Pro Trp Ile Tyr Glu Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
        195                 200                 205             


Asn Asn Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Asn Tyr Pro Ser Met Tyr Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Arg 
        


<210>  173
<211>  242
<212>  PRT
<213>  Unknown

<220>
<223>  scFv sequence

<400>  173

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile His Ser Gly Gly Gly Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Gln Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Thr His Asn Tyr Glu Ser Thr Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ala Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Thr Thr 
    130                 135                 140                 


Met Thr Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ala Ser 
                165                 170                 175     


Pro Lys Pro Trp Ile Tyr Glu Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
        195                 200                 205             


Asn Asn Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Asn Tyr Pro Ser Met Tyr Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Arg 
        


<210>  174
<211>  242
<212>  PRT
<213>  Unknown

<220>
<223>  scFv sequence

<400>  174

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Asn Gly Gly Gly Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Gln Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Thr His Asn Tyr Glu Ser Thr Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ala Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Thr Pro 
    130                 135                 140                 


Met Thr Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ala Ser 
                165                 170                 175     


Pro Lys Pro Trp Ile Tyr Glu Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
        195                 200                 205             


Asn Asn Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Asn Tyr Pro Ser Met Tyr Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
225                 230                 235                 240 


Lys Arg 
        


<210>  175
<211>  242
<212>  PRT
<213>  Unknown

<220>
<223>  scFv

<400>  175

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Asn Gly Gly Gly Asn Ser Phe Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Gln Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Thr His Asn Tyr Glu Ser Thr Val Phe Asp Tyr Trp Gly Arg Gly 
            100                 105                 110         


Val Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Thr Thr 
    130                 135                 140                 


Met Thr Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ala Ser 
                165                 170                 175     


Pro Lys Pro Trp Ile Tyr Glu Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
        195                 200                 205             


Asn Asn Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Asn Tyr Pro Ser Met Tyr Thr Phe Gly Pro Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Arg 
        


<210>  176
<211>  242
<212>  PRT
<213>  Unknown

<220>
<223>  scFv sequence

<400>  176

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Gly Ser Gly Gly Ser Asp Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Gln Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Thr His Asn Tyr Glu Ser Thr Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Val Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Thr Val Leu Thr Gln Ser Pro Thr Ser 
    130                 135                 140                 


Met Thr Ala Ser Pro Gly Glu Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ala Ser 
                165                 170                 175     


Pro Lys Pro Trp Ile Tyr Glu Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
        195                 200                 205             


Asn Asn Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Asn Tyr Pro Ser Met Tyr Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Arg 
        


<210>  177
<211>  242
<212>  PRT
<213>  Unknown

<220>
<223>  scFv sequence

<400>  177

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asn Ser Gly Gly Gly Asp Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Gln Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Thr His Asn Tyr Glu Ser Thr Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Val Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Thr Thr 
    130                 135                 140                 


Met Thr Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ala Ser 
                165                 170                 175     


Pro Lys Pro Trp Ile Tyr Glu Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Phe 
        195                 200                 205             


Asn Asn Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Asn Tyr Pro Ser Met Tyr Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
225                 230                 235                 240 


Lys Arg 
        


<210>  178
<211>  242
<212>  PRT
<213>  Unknown

<220>
<223>  scFv sequence

<400>  178

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Gly Gly Gly Asp Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Gln Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Thr His Asn Tyr Glu Ser Thr Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ala Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Thr Thr 
    130                 135                 140                 


Thr Ala Ala Ser Pro Gly Glu Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ala Ser 
                165                 170                 175     


Pro Lys Pro Trp Ile Tyr Glu Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
        195                 200                 205             


Asn Asn Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Asn Tyr Pro Ser Met Tyr Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Arg 
        


<210>  179
<211>  242
<212>  PRT
<213>  Unknown

<220>
<223>  scFv sequence

<400>  179

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Gly Asn Tyr 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Val Asn Ser Gly Gly Gly Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Gln Tyr 
65                  70                  75                  80  


Leu His Ile Asp Gly Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Thr His Asn Tyr Glu Ser Thr Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ala Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Ile Ile Leu Thr Gln Ser Pro Thr Thr 
    130                 135                 140                 


Met Thr Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ala Ser 
                165                 170                 175     


Pro Lys Pro Trp Ile Tyr Glu Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
        195                 200                 205             


Asn Asn Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Asn Tyr Pro Ser Met Tyr Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
225                 230                 235                 240 


Lys Arg 
        


<210>  180
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  HCDR2

<400>  180

Ile Ser Ser Gly Ala Gly Asn Thr 
1               5               


<210>  181
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  HCDR2

<400>  181

Ile Asn Ser Gly Gly Gly Asn Thr 
1               5               


<210>  182
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  HCDR2

<400>  182

Ile His Ser Gly Gly Gly Asn Thr 
1               5               


<210>  183
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  HCDR2

<400>  183

Ile Ser Asn Gly Gly Gly Asn Ser 
1               5               


<210>  184
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  HCDR2

<400>  184

Ile Gly Ser Gly Gly Ser Asp Thr 
1               5               


<210>  185
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  HCDR1

<400>  185

Gly Phe Thr Phe Ser Thr Tyr Ala 
1               5               


<210>  186
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  HCDR2

<400>  186

Ile Asn Ser Gly Gly Gly Asp Thr 
1               5               


<210>  187
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  HCDR1

<400>  187

Gly Phe Ile Phe Gly Asn Tyr Ala 
1               5               


<210>  188
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  HCDR2

<400>  188

Val Asn Ser Gly Gly Gly Asn Thr 
1               5               


