                         SEQUENCE LISTING

<110>  Cellis AG
 
<120>  FERRITIN VARIANTS WITH INCREASED STABILITY AND COMPLEXATION 
       ABILITY

<130>  976-11 PCT2

<150>  PCT/EP2021/056996
<151>  2021-03-18

<160>  87    

<170>  PatentIn version 3.5

<210>  1
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp 
1               5                   10                  15      


Ser Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser 
            20                  25                  30          


Tyr Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala 
        35                  40                  45              


Leu Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg 
    50                  55                  60                  


Glu His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg 
65                  70                  75                  80  


Ile Phe Leu Gln Asp Ile Lys Lys Pro Asp Cys Asp Asp Trp Glu Ser 
                85                  90                  95      


Gly Leu Asn Ala Met Glu Cys Ala Leu His Leu Glu Lys Asn Val Asn 
            100                 105                 110         


Gln Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro 
        115                 120                 125             


His Leu Cys Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys 
    130                 135                 140                 


Ala Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly 
145                 150                 155                 160 


Ala Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu 
                165                 170                 175     


Gly Asp Ser Asp Asn Glu Ser 
            180             


<210>  2
<211>  182
<212>  PRT
<213>  Mus musculus

<400>  2

Met Thr Thr Ala Ser Pro Ser Gln Val Arg Gln Asn Tyr His Gln Asp 
1               5                   10                  15      


Ala Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser 
            20                  25                  30          


Tyr Val Tyr Leu Ser Met Ser Cys Tyr Phe Asp Arg Asp Asp Val Ala 
        35                  40                  45              


Leu Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg 
    50                  55                  60                  


Glu His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg 
65                  70                  75                  80  


Ile Phe Leu Gln Asp Ile Lys Lys Pro Asp Arg Asp Asp Trp Glu Ser 
                85                  90                  95      


Gly Leu Asn Ala Met Glu Cys Ala Leu His Leu Glu Lys Ser Val Asn 
            100                 105                 110         


Gln Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro 
        115                 120                 125             


His Leu Cys Asp Phe Ile Glu Thr Tyr Tyr Leu Ser Glu Gln Val Lys 
    130                 135                 140                 


Ser Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly 
145                 150                 155                 160 


Ala Pro Glu Ala Gly Met Ala Glu Tyr Leu Phe Asp Lys His Thr Leu 
                165                 170                 175     


Gly His Gly Asp Glu Ser 
            180         


<210>  3
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human/mouse


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  S or T, preferably T

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Q or E

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Q or E

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  N or D

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Q or E

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  S or A, preferably S

<400>  3

Met Thr Thr Ala Ser Xaa Ser Glx Val Arg Glx Asx Tyr His Glx Asp 
1               5                   10                  15      


Xaa Glu Ala Ala 
            20  


<210>  4
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Thr Thr Ala Ser Thr Ser Glu Val Arg Gln Asn Tyr His Gln Asp 
1               5                   10                  15      


Ser Glu Ala Ala 
            20  


<210>  5
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Thr Thr Ala Ser Thr Ser Gln Val Arg Glu Asn Tyr His Gln Asp 
1               5                   10                  15      


Ser Glu Ala Ala 
            20  


<210>  6
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asp Tyr His Gln Asp 
1               5                   10                  15      


Ser Glu Ala Ala 
            20  


<210>  7
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Glu Asp 
1               5                   10                  15      


Ser Glu Ala Ala 
            20  


<210>  8
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Thr Thr Ala Ser Thr Ser Glu Val Arg Glu Asn Tyr His Gln Asp 
1               5                   10                  15      


Ser Glu Ala Ala 
            20  


<210>  9
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Thr Thr Ala Ser Thr Ser Glu Val Arg Gln Asp Tyr His Gln Asp 
1               5                   10                  15      


Ser Glu Ala Ala 
            20  


<210>  10
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Thr Thr Ala Ser Thr Ser Glu Val Arg Gln Asn Tyr His Glu Asp 
1               5                   10                  15      


Ser Glu Ala Ala 
            20  


<210>  11
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Thr Thr Ala Ser Thr Ser Gln Val Arg Glu Asp Tyr His Gln Asp 
1               5                   10                  15      


Ser Glu Ala Ala 
            20  


<210>  12
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Thr Thr Ala Ser Thr Ser Gln Val Arg Glu Asn Tyr His Glu Asp 
1               5                   10                  15      


Ser Glu Ala Ala 
            20  


<210>  13
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asp Tyr His Glu Asp 
1               5                   10                  15      


Ser Glu Ala Ala 
            20  


<210>  14
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Thr Thr Ala Ser Thr Ser Glu Val Arg Glu Asp Tyr His Gln Asp 
1               5                   10                  15      


Ser Glu Ala Ala 
            20  


<210>  15
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Thr Thr Ala Ser Thr Ser Glu Val Arg Glu Asn Tyr His Glu Asp 
1               5                   10                  15      


Ser Glu Ala Ala 
            20  


<210>  16
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Thr Thr Ala Ser Thr Ser Glu Val Arg Gln Asp Tyr His Glu Asp 
1               5                   10                  15      


Ser Glu Ala Ala 
            20  


<210>  17
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Thr Thr Ala Ser Thr Ser Gln Val Arg Glu Asp Tyr His Glu Asp 
1               5                   10                  15      


Ser Glu Ala Ala 
            20  


<210>  18
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp 
1               5                   10                  15      


Ser Glu Ala Ala 
            20  


<210>  19
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  19

Met Thr Thr Ala Ser Ser Ser Glu Val Arg Gln Asn Tyr His Gln Asp 
1               5                   10                  15      


Ala Glu Ala Ala 
            20  


<210>  20
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  20

Met Thr Thr Ala Ser Ser Ser Gln Val Arg Glu Asn Tyr His Gln Asp 
1               5                   10                  15      


Ala Glu Ala Ala 
            20  


<210>  21
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  21

Met Thr Thr Ala Ser Ser Ser Gln Val Arg Gln Asp Tyr His Gln Asp 
1               5                   10                  15      


Ala Glu Ala Ala 
            20  


<210>  22
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  22

Met Thr Thr Ala Ser Ser Ser Gln Val Arg Gln Asn Tyr His Glu Asp 
1               5                   10                  15      


Ala Glu Ala Ala 
            20  


<210>  23
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  23

Met Thr Thr Ala Ser Ser Ser Glu Val Arg Glu Asn Tyr His Gln Asp 
1               5                   10                  15      


Ala Glu Ala Ala 
            20  


<210>  24
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  24

Met Thr Thr Ala Ser Ser Ser Glu Val Arg Gln Asp Tyr His Gln Asp 
1               5                   10                  15      


Ala Glu Ala Ala 
            20  


<210>  25
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  25

Met Thr Thr Ala Ser Ser Ser Glu Val Arg Gln Asn Tyr His Glu Asp 
1               5                   10                  15      


Ala Glu Ala Ala 
            20  


<210>  26
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  26

Met Thr Thr Ala Ser Ser Ser Gln Val Arg Glu Asp Tyr His Gln Asp 
1               5                   10                  15      


Ala Glu Ala Ala 
            20  


<210>  27
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  27

Met Thr Thr Ala Ser Ser Ser Gln Val Arg Glu Asn Tyr His Glu Asp 
1               5                   10                  15      


Ala Glu Ala Ala 
            20  


<210>  28
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  28

Met Thr Thr Ala Ser Ser Ser Gln Val Arg Gln Asp Tyr His Glu Asp 
1               5                   10                  15      


Ala Glu Ala Ala 
            20  


<210>  29
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  29

Met Thr Thr Ala Ser Ser Ser Glu Val Arg Glu Asp Tyr His Gln Asp 
1               5                   10                  15      


Ala Glu Ala Ala 
            20  


<210>  30
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  30

Met Thr Thr Ala Ser Ser Ser Glu Val Arg Glu Asn Tyr His Glu Asp 
1               5                   10                  15      


Ala Glu Ala Ala 
            20  


<210>  31
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  31

Met Thr Thr Ala Ser Ser Ser Glu Val Arg Gln Asp Tyr His Glu Asp 
1               5                   10                  15      


Ala Glu Ala Ala 
            20  


<210>  32
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  32

Met Thr Thr Ala Ser Ser Ser Gln Val Arg Glu Asp Tyr His Glu Asp 
1               5                   10                  15      


Ala Glu Ala Ala 
            20  


<210>  33
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  33

Met Thr Thr Ala Ser Ser Ser Gln Val Arg Gln Asn Tyr His Gln Asp 
1               5                   10                  15      


Ala Glu Ala Ala 
            20  


<210>  34
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human/mouse

<400>  34

Met Thr Thr Ala Ser Thr Ser Glu Val Arg Gln Asn Tyr His Gln Asp 
1               5                   10                  15      


Ala Glu Ala Ala 
            20  


<210>  35
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human/mouse

<400>  35

Met Thr Thr Ala Ser Thr Ser Gln Val Arg Glu Asn Tyr His Gln Asp 
1               5                   10                  15      


Ala Glu Ala Ala 
            20  


<210>  36
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human/mouse

<400>  36

Met Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asp Tyr His Gln Asp 
1               5                   10                  15      


Ala Glu Ala Ala 
            20  


<210>  37
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human/mouse

<400>  37

Met Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Glu Asp 
1               5                   10                  15      


Ala Glu Ala Ala 
            20  


<210>  38
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human/mouse

<400>  38

Met Thr Thr Ala Ser Thr Ser Glu Val Arg Glu Asn Tyr His Gln Asp 
1               5                   10                  15      


Ala Glu Ala Ala 
            20  


<210>  39
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human/mouse

<400>  39

Met Thr Thr Ala Ser Thr Ser Glu Val Arg Gln Asp Tyr His Gln Asp 
1               5                   10                  15      


Ala Glu Ala Ala 
            20  


<210>  40
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human/mouse

<400>  40

Met Thr Thr Ala Ser Thr Ser Glu Val Arg Gln Asn Tyr His Glu Asp 
1               5                   10                  15      


Ala Glu Ala Ala 
            20  


<210>  41
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human/mouse

<400>  41

Met Thr Thr Ala Ser Thr Ser Gln Val Arg Glu Asp Tyr His Gln Asp 
1               5                   10                  15      


Ala Glu Ala Ala 
            20  


<210>  42
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human/mouse

<400>  42

Met Thr Thr Ala Ser Thr Ser Gln Val Arg Glu Asn Tyr His Glu Asp 
1               5                   10                  15      


Ala Glu Ala Ala 
            20  


<210>  43
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human/mouse

<400>  43

Met Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asp Tyr His Glu Asp 
1               5                   10                  15      


Ala Glu Ala Ala 
            20  


<210>  44
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human/mouse

<400>  44

Met Thr Thr Ala Ser Thr Ser Glu Val Arg Glu Asp Tyr His Gln Asp 
1               5                   10                  15      


Ala Glu Ala Ala 
            20  


<210>  45
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human/mouse

<400>  45

Met Thr Thr Ala Ser Thr Ser Glu Val Arg Glu Asn Tyr His Glu Asp 
1               5                   10                  15      


Ala Glu Ala Ala 
            20  


<210>  46
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human/mouse

<400>  46

Met Thr Thr Ala Ser Thr Ser Glu Val Arg Gln Asp Tyr His Glu Asp 
1               5                   10                  15      


Ala Glu Ala Ala 
            20  


<210>  47
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human/mouse

<400>  47

Met Thr Thr Ala Ser Thr Ser Gln Val Arg Glu Asp Tyr His Glu Asp 
1               5                   10                  15      


Ala Glu Ala Ala 
            20  


<210>  48
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human/mouse

<400>  48

Met Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp 
1               5                   10                  15      


Ala Glu Ala Ala 
            20  


<210>  49
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human/mouse

<400>  49

Met Thr Thr Ala Ser Ser Ser Glu Val Arg Gln Asn Tyr His Gln Asp 
1               5                   10                  15      


Ser Glu Ala Ala 
            20  


<210>  50
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human/mouse

<400>  50

Met Thr Thr Ala Ser Ser Ser Gln Val Arg Glu Asn Tyr His Gln Asp 
1               5                   10                  15      


Ser Glu Ala Ala 
            20  


<210>  51
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human/mouse

<400>  51

Met Thr Thr Ala Ser Ser Ser Gln Val Arg Gln Asp Tyr His Gln Asp 
1               5                   10                  15      


Ser Glu Ala Ala 
            20  


<210>  52
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human/mouse

<400>  52

Met Thr Thr Ala Ser Ser Ser Gln Val Arg Gln Asn Tyr His Glu Asp 
1               5                   10                  15      


Ser Glu Ala Ala 
            20  


<210>  53
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human/mouse

<400>  53

Met Thr Thr Ala Ser Ser Ser Glu Val Arg Glu Asn Tyr His Gln Asp 
1               5                   10                  15      


Ser Glu Ala Ala 
            20  


<210>  54
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human/mouse

<400>  54

Met Thr Thr Ala Ser Ser Ser Glu Val Arg Gln Asp Tyr His Gln Asp 
1               5                   10                  15      


Ser Glu Ala Ala 
            20  


<210>  55
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human/mouse

<400>  55

Met Thr Thr Ala Ser Ser Ser Glu Val Arg Gln Asn Tyr His Glu Asp 
1               5                   10                  15      


Ser Glu Ala Ala 
            20  


<210>  56
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human/mouse

<400>  56

Met Thr Thr Ala Ser Ser Ser Gln Val Arg Glu Asp Tyr His Gln Asp 
1               5                   10                  15      


Ser Glu Ala Ala 
            20  


<210>  57
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human/mouse

<400>  57

Met Thr Thr Ala Ser Ser Ser Gln Val Arg Glu Asn Tyr His Glu Asp 
1               5                   10                  15      


Ser Glu Ala Ala 
            20  


<210>  58
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human/mouse

<400>  58

Met Thr Thr Ala Ser Ser Ser Gln Val Arg Gln Asp Tyr His Glu Asp 
1               5                   10                  15      


Ser Glu Ala Ala 
            20  


<210>  59
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human/mouse

<400>  59

Met Thr Thr Ala Ser Ser Ser Glu Val Arg Glu Asp Tyr His Gln Asp 
1               5                   10                  15      


Ser Glu Ala Ala 
            20  


<210>  60
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human/mouse

<400>  60

Met Thr Thr Ala Ser Ser Ser Glu Val Arg Glu Asn Tyr His Glu Asp 
1               5                   10                  15      


Ser Glu Ala Ala 
            20  


<210>  61
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human/mouse

<400>  61

Met Thr Thr Ala Ser Ser Ser Glu Val Arg Gln Asp Tyr His Glu Asp 
1               5                   10                  15      


Ser Glu Ala Ala 
            20  


<210>  62
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human/mouse

<400>  62

Met Thr Thr Ala Ser Ser Ser Gln Val Arg Glu Asp Tyr His Glu Asp 
1               5                   10                  15      


Ser Glu Ala Ala 
            20  


<210>  63
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human/mouse

<400>  63

Met Thr Thr Ala Ser Ser Ser Gln Val Arg Gln Asn Tyr His Gln Asp 
1               5                   10                  15      


Ser Glu Ala Ala 
            20  


<210>  64
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mammalian consensus


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (71)..(71)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (86)..(86)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (90)..(90)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (117)..(117)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (120)..(120)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (125)..(125)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (144)..(144)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (146)..(146)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (158)..(158)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (161)..(163)
<223>  Xaa can be any naturally occurring amino acid

<400>  64

Xaa Xaa Arg Gln Ile Asn Leu Glu Leu Xaa Ala Ser Tyr Val Tyr Leu 
1               5                   10                  15      


Ser Met Ser Xaa Tyr Phe Asp Arg Asp Asp Val Ala Leu Lys Asn Phe 
            20                  25                  30          


Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu His Ala Glu 
        35                  40                  45              


Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile Xaa Leu Xaa 
    50                  55                  60                  


Asp Ile Lys Lys Pro Asp Xaa Asp Asp Trp Glu Ser Gly Leu Asn Ala 
65                  70                  75                  80  


Met Glu Cys Ala Leu Xaa Leu Glu Lys Xaa Val Asn Gln Ser Leu Leu 
                85                  90                  95      


Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His Leu Cys Asp 
            100                 105                 110         


Phe Ile Glu Thr Xaa Tyr Leu Xaa Glu Gln Val Lys Xaa Ile Lys Glu 
        115                 120                 125             


Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala Pro Glu Xaa 
    130                 135                 140                 


Gly Xaa Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly Xaa Ser Asp 
145                 150                 155                 160 


Xaa Xaa Xaa 
            


<210>  65
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mammalian consensus


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  any naturally occurring amino acid, preferably Pro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  any naturally occurring amino acid, preferably His

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  any naturally occurring amino acid, preferably Asp

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  may be present or absent, if present it means any naturally 
       occurring amino acid, preferably Ile

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  any naturally occurring amino acid, preferably Asn

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  any naturally occurring amino acid, preferably Tyr

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  any naturally occurring amino acid, preferably Tyr or Cys, more 
       preferably Cys

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (71)..(71)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (82)..(82)
<223>  any naturally occurring amino acid, preferably Phe

<220>
<221>  MISC_FEATURE
<222>  (84)..(84)
<223>  any naturally occurring amino acid, preferably Gln

<220>
<221>  misc_feature
<222>  (86)..(86)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (90)..(90)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (91)..(91)
<223>  any naturally occurring amino acid, preferably Arg or Cys, more 
       preferably Cys

<220>
<221>  MISC_FEATURE
<222>  (106)..(106)
<223>  any naturally occurring amino acid, preferably His

<220>
<221>  MISC_FEATURE
<222>  (110)..(110)
<223>  any naturally occurring amino acid, preferably Asn or Ser, more 
       preferably Asn

<220>
<221>  misc_feature
<222>  (117)..(117)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (120)..(120)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (125)..(125)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (137)..(137)
<223>  any naturally occurring amino acid, preferably His or Tyr, more 
       preferably His

<220>
<221>  MISC_FEATURE
<222>  (140)..(140)
<223>  any naturally occurring amino acid, preferably Asn or Ser, more 
       preferably Asn

<220>
<221>  MISC_FEATURE
<222>  (145)..(145)
<223>  any naturally occurring amino acid, preferably Ala or Ser, more 
       preferably Ala

<220>
<221>  MISC_FEATURE
<222>  (164)..(164)
<223>  any naturally occurring amino acid, preferably Ala or Ser, more 
       preferably Ser

<220>
<221>  MISC_FEATURE
<222>  (166)..(166)
<223>  any naturally occurring amino acid, preferably Met or Leu, more 
       preferably Leu

<220>
<221>  MISC_FEATURE
<222>  (178)..(178)
<223>  any naturally occurring amino acid, preferably Asp or His, more 
       preferably Asp

<220>
<221>  MISC_FEATURE
<222>  (181)..(181)
<223>  may be present or absent, if present it means any amino acid, 
       preferably Asn

<220>
<221>  MISC_FEATURE
<222>  (182)..(182)
<223>  may be present or absent, if present it means any amino acid, 
       preferably Glu

<220>
<221>  MISC_FEATURE
<222>  (183)..(183)
<223>  may be present or absent, if present it means any amino acid, 
       preferably Ser

<400>  65

Xaa Xaa Arg Gln Ile Asn Leu Glu Leu Xaa Ala Ser Tyr Val Tyr Leu 
1               5                   10                  15      


Ser Met Ser Xaa Tyr Phe Asp Arg Asp Asp Val Ala Leu Lys Asn Phe 
            20                  25                  30          


Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu His Ala Glu 
        35                  40                  45              


Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile Xaa Leu Xaa 
    50                  55                  60                  


Asp Ile Lys Lys Pro Asp Xaa Asp Asp Trp Glu Ser Gly Leu Asn Ala 
65                  70                  75                  80  


Met Glu Cys Ala Leu Xaa Leu Glu Lys Xaa Val Asn Gln Ser Leu Leu 
                85                  90                  95      


Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His Leu Cys Asp 
            100                 105                 110         


Phe Ile Glu Thr Xaa Tyr Leu Xaa Glu Gln Val Lys Xaa Ile Lys Glu 
        115                 120                 125             


Leu 
    


<210>  66
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mammalian consensus


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (124)..(124)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (160)..(162)
<223>  Xaa can be any naturally occurring amino acid

<400>  66

Xaa Arg Gln Ile Asn Leu Glu Leu Xaa Ala Ser Tyr Val Tyr Leu Ser 
1               5                   10                  15      


Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu Lys Asn Phe Ala 
            20                  25                  30          


Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu His Ala Glu Lys 
        35                  40                  45              


Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile Xaa Leu Xaa Asp 
    50                  55                  60                  


Ile Lys Lys Pro Asp Cys Asp Asp Trp Glu Ser Gly Leu Asn Ala Met 
65                  70                  75                  80  


Glu Cys Ala Leu Xaa Leu Glu Lys Asn Val Asn Gln Ser Leu Leu Glu 
                85                  90                  95      


Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His Leu Cys Asp Phe 
            100                 105                 110         


Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Xaa Ile Lys Glu Leu 
        115                 120                 125             


Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala Pro Glu Ser Gly 
    130                 135                 140                 


Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly Asp Ser Asp Xaa 
145                 150                 155                 160 


Xaa Xaa 
        


<210>  67
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  67

Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr Val Tyr Leu 
1               5                   10                  15      


Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu Lys Asn Phe 
            20                  25                  30          


Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu His Ala Glu 
        35                  40                  45              


Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile Phe Leu Gln 
    50                  55                  60                  


Asp Ile Lys Lys Pro Asp Cys Asp Asp Trp Glu Ser Gly Leu Asn Ala 
65                  70                  75                  80  


Met Glu Cys Ala Leu His Leu Glu Lys Asn Val Asn Gln Ser Leu Leu 
                85                  90                  95      


Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His Leu Cys Asp 
            100                 105                 110         


Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala Ile Lys Glu 
        115                 120                 125             


Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala Pro Glu Ser 
    130                 135                 140                 


Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly Asp Ser Asp 
145                 150                 155                 160 


Asn Glu Ser 
            


<210>  68
<211>  162
<212>  PRT
<213>  Mus musculus

<400>  68

Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr Val Tyr Leu 
1               5                   10                  15      


Ser Met Ser Cys Tyr Phe Asp Arg Asp Asp Val Ala Leu Lys Asn Phe 
            20                  25                  30          


Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu His Ala Glu 
        35                  40                  45              


Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile Phe Leu Gln 
    50                  55                  60                  


Asp Ile Lys Lys Pro Asp Arg Asp Asp Trp Glu Ser Gly Leu Asn Ala 
65                  70                  75                  80  


Met Glu Cys Ala Leu His Leu Glu Lys Ser Val Asn Gln Ser Leu Leu 
                85                  90                  95      


Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His Leu Cys Asp 
            100                 105                 110         


Phe Ile Glu Thr Tyr Tyr Leu Ser Glu Gln Val Lys Ser Ile Lys Glu 
        115                 120                 125             


Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala Pro Glu Ala 
    130                 135                 140                 


Gly Met Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly His Gly Asp 
145                 150                 155                 160 


Glu Ser 
        


<210>  69
<211>  162
<212>  PRT
<213>  Rattus norvegicus

<400>  69

Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr Val Tyr Leu 
1               5                   10                  15      


Ser Met Ser Cys Tyr Phe Asp Arg Asp Asp Val Ala Leu Lys Asn Phe 
            20                  25                  30          


Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu His Ala Glu 
        35                  40                  45              


Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile Phe Leu Gln 
    50                  55                  60                  


Asp Ile Lys Lys Pro Asp Arg Asp Asp Trp Glu Ser Gly Leu Asn Ala 
65                  70                  75                  80  


Met Glu Cys Ala Leu His Leu Glu Lys Ser Val Asn Gln Ser Leu Leu 
                85                  90                  95      


Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His Leu Cys Asp 
            100                 105                 110         


Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ser Ile Lys Glu 
        115                 120                 125             


Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala Pro Glu Ser 
    130                 135                 140                 


Gly Met Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly His Gly Asp 
145                 150                 155                 160 


Glu Ser 
        


<210>  70
<211>  163
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  70

Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr Val Tyr Leu 
1               5                   10                  15      


Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu Lys Asn Phe 
            20                  25                  30          


Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu His Ala Glu 
        35                  40                  45              


Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile Phe Leu Gln 
    50                  55                  60                  


Asp Ile Lys Lys Pro Glu Tyr Asp Asp Trp Glu Ser Gly Leu Asn Ala 
65                  70                  75                  80  


Met Glu Cys Ala Leu His Leu Glu Lys Ser Val Asn Gln Ser Leu Leu 
                85                  90                  95      


Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His Leu Cys Asp 
            100                 105                 110         


Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ser Ile Lys Glu 
        115                 120                 125             


Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala Pro Glu Ser 
    130                 135                 140                 


Gly Met Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly His Ser Asp 
145                 150                 155                 160 


Asn Glu Ser 
            


<210>  71
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Thr Thr Ala Ser Thr Ser Gln Val Arg Glu Asn Tyr His Gln Asp 
1               5                   10                  15      


Ser Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser 
            20                  25                  30          


Tyr Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala 
        35                  40                  45              


Leu Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg 
    50                  55                  60                  


Glu His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg 
65                  70                  75                  80  


Ile Phe Leu Gln Asp Ile Lys Lys Pro Asp Cys Asp Asp Trp Glu Ser 
                85                  90                  95      


Gly Leu Asn Ala Met Glu Cys Ala Leu His Leu Glu Lys Asn Val Asn 
            100                 105                 110         


Gln Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro 
        115                 120                 125             


His Leu Cys Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys 
    130                 135                 140                 


Ala Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly 
145                 150                 155                 160 


Ala Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu 
                165                 170                 175     


Gly Asp Ser Asp Asn Glu Ser 
            180             


<210>  72
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Thr Thr Ala Ser Thr Ser Gln Val Arg Glu Asn Tyr His Glu Asp 
1               5                   10                  15      


Ser Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser 
            20                  25                  30          


Tyr Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala 
        35                  40                  45              


Leu Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg 
    50                  55                  60                  


Glu His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg 
65                  70                  75                  80  


Ile Phe Leu Gln Asp Ile Lys Lys Pro Asp Cys Asp Asp Trp Glu Ser 
                85                  90                  95      


Gly Leu Asn Ala Met Glu Cys Ala Leu His Leu Glu Lys Asn Val Asn 
            100                 105                 110         


Gln Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro 
        115                 120                 125             


His Leu Cys Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys 
    130                 135                 140                 


Ala Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly 
145                 150                 155                 160 


Ala Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu 
                165                 170                 175     


Gly Asp Ser Asp Asn Glu Ser 
            180             


<210>  73
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Thr Thr Ala Ser Thr Ser Glu Val Arg Glu Asn Tyr His Glu Asp 
1               5                   10                  15      


Ser Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser 
            20                  25                  30          


Tyr Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala 
        35                  40                  45              


Leu Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg 
    50                  55                  60                  


Glu His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg 
65                  70                  75                  80  


Ile Phe Leu Gln Asp Ile Lys Lys Pro Asp Cys Asp Asp Trp Glu Ser 
                85                  90                  95      


Gly Leu Asn Ala Met Glu Cys Ala Leu His Leu Glu Lys Asn Val Asn 
            100                 105                 110         


Gln Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro 
        115                 120                 125             


His Leu Cys Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys 
    130                 135                 140                 


Ala Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly 
145                 150                 155                 160 


Ala Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu 
                165                 170                 175     


Gly Asp Ser Asp Asn Glu Ser 
            180             


<210>  74
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Thr Thr Ala Ser Thr Ser Gln Val Arg Glu Asp Tyr His Gln Asp 
1               5                   10                  15      


Ser Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser 
            20                  25                  30          


Tyr Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala 
        35                  40                  45              


Leu Lys Asn Phe Ala Glu Tyr Phe Leu His Gln Ser His Glu Glu Arg 
    50                  55                  60                  


Glu His Ala Glu Lys Leu Met Glu Leu Gln Asn Gln Arg Gly Gly Arg 
65                  70                  75                  80  


Ile Phe Leu Gln Asp Ile Gln Lys Pro Asp Ser Asp Asp Trp Glu Ser 
                85                  90                  95      


Gly Leu Asn Ala Met Glu Ser Ala Leu His Leu Glu Lys Asn Val Asn 
            100                 105                 110         


Gln Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro 
        115                 120                 125             


His Leu Ser Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Glu 
    130                 135                 140                 


Ala Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly 
145                 150                 155                 160 


Ala Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu 
                165                 170                 175     


Gly Asp Ser Asp Asn Glu Ser 
            180             


<210>  75
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Thr Thr Ala Ser Thr Ser Gln Val Arg Glu Asn Tyr His Gln Asp 
1               5                   10                  15      


Ser Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser 
            20                  25                  30          


Tyr Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala 
        35                  40                  45              


Leu Lys Asn Phe Ala Glu Tyr Phe Leu His Gln Ser His Glu Glu Arg 
    50                  55                  60                  


Glu His Ala Glu Lys Leu Met Glu Leu Gln Asn Gln Arg Gly Gly Arg 
65                  70                  75                  80  


Ile Phe Leu Gln Asp Ile Gln Lys Pro Asp Ser Asp Asp Trp Glu Ser 
                85                  90                  95      


Gly Leu Asn Ala Met Glu Ser Ala Leu His Leu Glu Lys Asn Val Asn 
            100                 105                 110         


Gln Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro 
        115                 120                 125             


His Leu Ser Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Glu 
    130                 135                 140                 


Ala Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly 
145                 150                 155                 160 


Ala Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu 
                165                 170                 175     


Gly Asp Ser Asp Asn Glu Ser 
            180             


<210>  76
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Thr Thr Ala Ser Thr Ser Gln Val Arg Glu Asn Tyr His Glu Asp 
1               5                   10                  15      


Ser Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser 
            20                  25                  30          


Tyr Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala 
        35                  40                  45              


Leu Lys Asn Phe Ala Glu Tyr Phe Leu His Gln Ser His Glu Glu Arg 
    50                  55                  60                  


Glu His Ala Glu Lys Leu Met Glu Leu Gln Asn Gln Arg Gly Gly Arg 
65                  70                  75                  80  


Ile Phe Leu Gln Asp Ile Gln Lys Pro Asp Ser Asp Asp Trp Glu Ser 
                85                  90                  95      


Gly Leu Asn Ala Met Glu Ser Ala Leu His Leu Glu Lys Asn Val Asn 
            100                 105                 110         


Gln Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro 
        115                 120                 125             


His Leu Cys Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Glu 
    130                 135                 140                 


Ala Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly 
145                 150                 155                 160 


Ala Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu 
                165                 170                 175     


Gly Asp Ser Asp Asn Glu Ser 
            180             


<210>  77
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Thr Thr Ala Ser Thr Ser Gln Val Arg Glu Asn Tyr His Glu Asp 
1               5                   10                  15      


Ser Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser 
            20                  25                  30          


Tyr Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala 
        35                  40                  45              


Leu Lys Asn Phe Ala Glu Tyr Phe Leu His Gln Ser His Glu Glu Arg 
    50                  55                  60                  


Glu His Ala Glu Lys Leu Met Glu Leu Gln Asn Gln Arg Gly Gly Arg 
65                  70                  75                  80  


Ile Phe Leu Gln Asp Ile Gln Lys Pro Asp Cys Asp Asp Trp Glu Ser 
                85                  90                  95      


Gly Leu Asn Ala Met Glu Cys Ala Leu His Leu Glu Lys Asn Val Asn 
            100                 105                 110         


Gln Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro 
        115                 120                 125             


His Leu Cys Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Glu 
    130                 135                 140                 


Ala Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly 
145                 150                 155                 160 


Ala Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu 
                165                 170                 175     


Gly Asp Ser Asp Asn Glu Ser 
            180             


<210>  78
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  78

Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr Val Tyr Leu 
1               5                   10                  15      


Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu Lys Asn Phe 
            20                  25                  30          


Ala Glu Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu His Ala Glu 
        35                  40                  45              


Lys Leu Met Glu Leu Gln Asn Gln Arg Gly Gly Arg Ile Phe Leu Gln 
    50                  55                  60                  


Asp Ile Gln Lys Pro Asp Ser Asp Asp Trp Glu Ser Gly Leu Asn Ala 
65                  70                  75                  80  


Met Glu Ser Ala Leu His Leu Glu Lys Asn Val Asn Gln Ser Leu Leu 
                85                  90                  95      


Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His Leu Ser Asp 
            100                 105                 110         


Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Glu Ala Ile Lys Glu 
        115                 120                 125             


Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala Pro Glu Ser 
    130                 135                 140                 


Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly Asp Ser Asp 
145                 150                 155                 160 


Asn Glu Ser 
            


<210>  79
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  79

Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr Val Tyr Leu 
1               5                   10                  15      


Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu Lys Asn Phe 
            20                  25                  30          


Ala Glu Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu His Ala Glu 
        35                  40                  45              


Lys Leu Met Glu Leu Gln Asn Gln Arg Gly Gly Arg Ile Phe Leu Gln 
    50                  55                  60                  


Asp Ile Gln Lys Pro Asp Ser Asp Asp Trp Glu Ser Gly Leu Asn Ala 
65                  70                  75                  80  


Met Glu Ser Ala Leu His Leu Glu Lys Asn Val Asn Gln Ser Leu Leu 
                85                  90                  95      


Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His Leu Cys Asp 
            100                 105                 110         


Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Glu Ala Ile Lys Glu 
        115                 120                 125             


Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala Pro Glu Ser 
    130                 135                 140                 


Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly Asp Ser Asp 
145                 150                 155                 160 


Asn Glu Ser 
            


<210>  80
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  80

Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr Val Tyr Leu 
1               5                   10                  15      


Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu Lys Asn Phe 
            20                  25                  30          


Ala Glu Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu His Ala Glu 
        35                  40                  45              


Lys Leu Met Glu Leu Gln Asn Gln Arg Gly Gly Arg Ile Phe Leu Gln 
    50                  55                  60                  


Asp Ile Gln Lys Pro Asp Cys Asp Asp Trp Glu Ser Gly Leu Asn Ala 
65                  70                  75                  80  


Met Glu Cys Ala Leu His Leu Glu Lys Asn Val Asn Gln Ser Leu Leu 
                85                  90                  95      


Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His Leu Cys Asp 
            100                 105                 110         


Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Glu Ala Ile Lys Glu 
        115                 120                 125             


Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala Pro Glu Ser 
    130                 135                 140                 


Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly Asp Ser Asp 
145                 150                 155                 160 


Asn Glu Ser 
            


<210>  81
<211>  20
<212>  PRT
<213>  human mouse consensus


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X1: S or T, preferably T

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Z1: Q or E

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Z2: Q or E

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  B: N or D

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Z3: Q or E

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X2: S or A, preferably S

<400>  81

Met Thr Thr Ala Ser Xaa Ser Glx Val Arg Glx Asx Tyr His Glx Asp 
1               5                   10                  15      


Xaa Glu Ala Ala 
            20  


<210>  82
<211>  183
<212>  PRT
<213>  mammalian consensus


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (91)..(91)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (110)..(110)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (137)..(137)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (140)..(140)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (145)..(145)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (164)..(164)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (166)..(166)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (178)..(178)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (181)..(183)
<223>  Xaa can be any naturally occurring amino acid

<400>  82

Met Thr Thr Ala Ser Xaa Ser Gln Val Arg Gln Asn Tyr Xaa Gln Xaa 
1               5                   10                  15      


Ser Glu Ala Ala Xaa Xaa Arg Gln Ile Asn Leu Glu Leu Xaa Ala Ser 
            20                  25                  30          


Tyr Val Tyr Leu Ser Met Ser Xaa Tyr Phe Asp Arg Asp Asp Val Ala 
        35                  40                  45              


Leu Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg 
    50                  55                  60                  


Glu His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg 
65                  70                  75                  80  


Ile Xaa Leu Xaa Asp Ile Lys Lys Pro Asp Xaa Asp Asp Trp Glu Ser 
                85                  90                  95      


Gly Leu Asn Ala Met Glu Cys Ala Leu Xaa Leu Glu Lys Xaa Val Asn 
            100                 105                 110         


Gln Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro 
        115                 120                 125             


His Leu Cys Asp Phe Ile Glu Thr Xaa Tyr Leu Xaa Glu Gln Val Lys 
    130                 135                 140                 


Xaa Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly 
145                 150                 155                 160 


Ala Pro Glu Xaa Gly Xaa Ala Glu Tyr Leu Phe Asp Lys His Thr Leu 
                165                 170                 175     


Gly Xaa Ser Asp Xaa Xaa Xaa 
            180             


<210>  83
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp 
1               5                   10                  15      


Ser Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser 
            20                  25                  30          


Tyr Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala 
        35                  40                  45              


Leu Lys Asn Phe Ala Glu Tyr Phe Leu His Gln Ser His Glu Glu Arg 
    50                  55                  60                  


Glu His Ala Glu Lys Leu Met Glu Leu Gln Asn Gln Arg Gly Gly Arg 
65                  70                  75                  80  


Ile Phe Leu Gln Asp Ile Gln Lys Pro Asp Cys Asp Asp Trp Glu Ser 
                85                  90                  95      


Gly Leu Asn Ala Met Glu Cys Ala Leu His Leu Glu Lys Asn Val Asn 
            100                 105                 110         


Gln Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro 
        115                 120                 125             


His Leu Cys Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Glu 
    130                 135                 140                 


Ala Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly 
145                 150                 155                 160 


Ala Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu 
                165                 170                 175     


Gly Asp Ser Asp Asn Glu Ser 
            180             


<210>  84
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp 
1               5                   10                  15      


Ser Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser 
            20                  25                  30          


Tyr Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala 
        35                  40                  45              


Leu Lys Asn Phe Ala Glx Tyr Phe Leu His Gln Ser His Glu Glu Arg 
    50                  55                  60                  


Glu His Ala Glu Lys Leu Met Glx Leu Gln Asn Gln Arg Gly Gly Arg 
65                  70                  75                  80  


Ile Phe Leu Gln Asp Ile Glx Lys Pro Asp Cys Asp Asp Trp Glu Ser 
                85                  90                  95      


Gly Leu Asn Ala Met Glu Cys Ala Leu His Leu Glu Lys Asn Val Asn 
            100                 105                 110         


Gln Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro 
        115                 120                 125             


His Leu Cys Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Glx 
    130                 135                 140                 


Ala Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly 
145                 150                 155                 160 


Ala Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu 
                165                 170                 175     


Gly Asp Ser Asp Asn Glu Ser 
            180             


<210>  85
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Thr Thr Ala Ser Thr Ser Gln Val Arg Glu Asn Tyr His Glu Asp 
1               5                   10                  15      


Ser Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser 
            20                  25                  30          


Tyr Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala 
        35                  40                  45              


Leu Lys Asn Phe Ala Glx Tyr Phe Leu His Gln Ser His Glu Glu Arg 
    50                  55                  60                  


Glu His Ala Glu Lys Leu Met Glx Leu Gln Asn Gln Arg Gly Gly Arg 
65                  70                  75                  80  


Ile Phe Leu Gln Asp Ile Glx Lys Pro Asp Cys Asp Asp Trp Glu Ser 
                85                  90                  95      


Gly Leu Asn Ala Met Glu Cys Ala Leu His Leu Glu Lys Asn Val Asn 
            100                 105                 110         


Gln Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro 
        115                 120                 125             


His Leu Cys Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Glx 
    130                 135                 140                 


Ala Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly 
145                 150                 155                 160 


Ala Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu 
                165                 170                 175     


Gly Asp Ser Asp Asn Glu Ser 
            180             


<210>  86
<211>  183
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (91)..(91)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (110)..(110)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (137)..(137)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (140)..(140)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (145)..(145)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (164)..(164)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (166)..(166)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (178)..(178)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (181)..(183)
<223>  Xaa can be any naturally occurring amino acid

<400>  86

Met Thr Thr Ala Ser Xaa Ser Gln Val Arg Gln Asn Tyr Xaa Gln Xaa 
1               5                   10                  15      


Ser Glu Ala Ala Xaa Xaa Arg Gln Ile Asn Leu Glu Leu Xaa Ala Ser 
            20                  25                  30          


Tyr Val Tyr Leu Ser Met Ser Xaa Tyr Phe Asp Arg Asp Asp Val Ala 
        35                  40                  45              


Leu Lys Asn Phe Ala Glx Tyr Phe Leu His Gln Ser His Glu Glu Arg 
    50                  55                  60                  


Glu His Ala Glu Lys Leu Met Glx Leu Gln Asn Gln Arg Gly Gly Arg 
65                  70                  75                  80  


Ile Xaa Leu Xaa Asp Ile Glx Lys Pro Asp Xaa Asp Asp Trp Glu Ser 
                85                  90                  95      


Gly Leu Asn Ala Met Glu Cys Ala Leu Xaa Leu Glu Lys Xaa Val Asn 
            100                 105                 110         


Gln Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro 
        115                 120                 125             


His Leu Cys Asp Phe Ile Glu Thr Xaa Tyr Leu Xaa Glu Gln Val Glx 
    130                 135                 140                 


Xaa Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly 
145                 150                 155                 160 


Ala Pro Glu Xaa Gly Xaa Ala Glu Tyr Leu Phe Asp Lys His Thr Leu 
                165                 170                 175     


Gly Xaa Ser Asp Xaa Xaa Xaa 
            180             


<210>  87
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  87

Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr Val Tyr Leu 
1               5                   10                  15      


Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu Lys Asn Phe 
            20                  25                  30          


Ala Glx Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu His Ala Glu 
        35                  40                  45              


Lys Leu Met Glx Leu Gln Asn Gln Arg Gly Gly Arg Ile Phe Leu Gln 
    50                  55                  60                  


Asp Ile Glx Lys Pro Asp Cys Asp Asp Trp Glu Ser Gly Leu Asn Ala 
65                  70                  75                  80  


Met Glu Cys Ala Leu His Leu Glu Lys Asn Val Asn Gln Ser Leu Leu 
                85                  90                  95      


Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His Leu Cys Asp 
            100                 105                 110         


Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Glx Ala Ile Lys Glu 
        115                 120                 125             


Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala Pro Glu Ser 
    130                 135                 140                 


Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly Asp Ser Asp 
145                 150                 155                 160 


Asn Glu Ser 
            


