               SEQUENCE LISTING

<110> Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

<120> Protein having HDGF (hepatoma-derived growth factor) function for use in treating and preventing neurodegenerative diseases

<130> AE1487 PCT

<150> EP 21 163 569.3
<151> 2021-03-18

<160> 4

<170> BiSSAP 1.3.6

<210> 1
<211> 240
<212> PRT
<213> Homo sapiens


<220> 
<223> hepatoma-derived growth factor (HDGF)

<400> 1
Met Ser Arg Ser Asn Arg Gln Lys Glu Tyr Lys Cys Gly Asp Leu Val 
1               5                   10                  15      
Phe Ala Lys Met Lys Gly Tyr Pro His Trp Pro Ala Arg Ile Asp Glu 
            20                  25                  30          
Met Pro Glu Ala Ala Val Lys Ser Thr Ala Asn Lys Tyr Gln Val Phe 
        35                  40                  45              
Phe Phe Gly Thr His Glu Thr Ala Phe Leu Gly Pro Lys Asp Leu Phe 
    50                  55                  60                  
Pro Tyr Glu Glu Ser Lys Glu Lys Phe Gly Lys Pro Asn Lys Arg Lys 
65                  70                  75                  80  
Gly Phe Ser Glu Gly Leu Trp Glu Ile Glu Asn Asn Pro Thr Val Lys 
                85                  90                  95      
Ala Ser Gly Tyr Gln Ser Ser Gln Lys Lys Ser Cys Val Glu Glu Pro 
            100                 105                 110         
Glu Pro Glu Pro Glu Ala Ala Glu Gly Asp Gly Asp Lys Lys Gly Asn 
        115                 120                 125             
Ala Glu Gly Ser Ser Asp Glu Glu Gly Lys Leu Val Ile Asp Glu Pro 
    130                 135                 140                 
Ala Lys Glu Lys Asn Glu Lys Gly Ala Leu Lys Arg Arg Ala Gly Asp 
145                 150                 155                 160 
Leu Leu Glu Asp Ser Pro Lys Arg Pro Lys Glu Ala Glu Asn Pro Glu 
                165                 170                 175     
Gly Glu Glu Lys Glu Ala Ala Thr Leu Glu Val Glu Arg Pro Leu Pro 
            180                 185                 190         
Met Glu Val Glu Lys Asn Ser Thr Pro Ser Glu Pro Gly Ser Gly Arg 
        195                 200                 205             
Gly Pro Pro Gln Glu Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu Ala 
    210                 215                 220                 
Thr Lys Glu Asp Ala Glu Ala Pro Gly Ile Arg Asp His Glu Ser Leu 
225                 230                 235                 240 



<210> 2
<211> 720
<212> DNA
<213> Homo sapiens


<220> 
<223> hepatoma-derived growth factor (HDGF)

<400> 2
atgtcgcgat ccaaccggca gaaggagtac aaatgcgggg acctggtgtt cgccaagatg      60

aagggctacc cacactggcc ggcccggatt gacgagatgc ctgaggctgc cgtgaaatca     120

acagccaaca aataccaagt cttttttttc gggacccacg agacggcatt cctgggcccc     180

aaagacctct tcccttacga ggaatccaag gagaagtttg gcaagcccaa caagaggaaa     240

gggttcagcg aggggctgtg ggagatcgaa aacaacccta ctgtcaaggc ttccggctat     300

cagtcctccc agaaaaagag ctgtgtggaa gagcctgaac cagagcccga agctgcagag     360

ggtgacggtg ataagaaggg gaatgcagag ggcagcagcg acgaggaagg gaagctggtc     420

attgatgagc cagccaagga gaagaacgag aaaggagcgt tgaagaggag agcaggggac     480

ttgctggagg actctcctaa acgtcccaag gaggcagaaa accctgaagg agaggagaag     540

gaggcagcca ccttggaggt tgagaggccc cttcctatgg aggtggaaaa gaatagcacc     600

ccctctgagc ccggctctgg ccgggggcct ccccaagagg aagaagaaga ggaggatgaa     660

gaggaagagg ctaccaagga agatgctgag gccccaggca tcagagatca tgagagcctg     720


<210> 3
<211> 256
<212> PRT
<213> Artificial Sequence


<220> 
<223> cytosolic version of HDGF (mHDGF-NES)

<400> 3
Met Ser Arg Ser Asn Arg Gln Lys Glu Tyr Lys Cys Gly Asp Leu Val 
1               5                   10                  15      
Phe Ala Lys Met Lys Gly Tyr Pro His Trp Pro Ala Arg Ile Asp Glu 
            20                  25                  30          
Met Pro Glu Ala Ala Val Lys Ser Thr Ala Asn Lys Tyr Gln Val Phe 
        35                  40                  45              
Phe Phe Gly Thr His Glu Thr Ala Phe Leu Gly Pro Lys Asp Leu Phe 
    50                  55                  60                  
Pro Tyr Glu Glu Ser Lys Glu Lys Phe Gly Asn Pro Asn Asn Gln Asn 
65                  70                  75                  80  
Gly Phe Ser Glu Gly Leu Trp Glu Ile Glu Asn Asn Pro Thr Val Lys 
                85                  90                  95      
Ala Ser Gly Tyr Gln Ser Ser Gln Lys Lys Ser Cys Val Glu Glu Pro 
            100                 105                 110         
Glu Pro Glu Pro Glu Ala Ala Glu Gly Asp Gly Asp Lys Lys Gly Asn 
        115                 120                 125             
Ala Glu Gly Ser Ser Asp Glu Glu Gly Lys Leu Val Ile Asp Glu Pro 
    130                 135                 140                 
Ala Lys Glu Lys Asn Glu Lys Gly Ala Leu Asn Gln Gln Ala Gly Asp 
145                 150                 155                 160 
Leu Leu Glu Asp Ser Pro Asn Arg Pro Asn Glu Ala Glu Asn Pro Glu 
                165                 170                 175     
Gly Glu Glu Lys Glu Ala Ala Thr Leu Glu Val Glu Arg Pro Leu Pro 
            180                 185                 190         
Met Glu Val Glu Lys Asn Ser Thr Pro Ser Glu Pro Gly Ser Gly Arg 
        195                 200                 205             
Gly Pro Pro Gln Glu Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu Ala 
    210                 215                 220                 
Thr Lys Glu Asp Ala Glu Ala Pro Gly Ile Arg Asp His Glu Ser Leu 
225                 230                 235                 240 
Ser Glu Leu Gln Asn Lys Leu Glu Glu Leu Asp Leu Asp Ser Tyr Lys 
                245                 250                 255     



<210> 4
<211> 768
<212> DNA
<213> Artificial Sequence


<220> 
<223> DNA encoding cytosolic version of HDGF (mHDGF-NES)

<400> 4
atgtcgcgat ccaaccggca gaaggagtac aaatgcgggg acctggtgtt cgccaagatg      60

aagggctacc cacactggcc ggcccggatt gacgagatgc ctgaggctgc cgtgaaatca     120

acagccaaca aataccaagt cttttttttc gggacccacg agacggcatt cctgggcccc     180

aaagacctct tcccttacga ggaatccaag gagaagtttg gcaaccccaa caatcagaat     240

gggttcagcg aggggctgtg ggagatcgaa aacaacccta ctgtcaaggc ttccggctat     300

cagtcctccc agaaaaagag ctgtgtggaa gagcctgaac cagagcccga agctgcagag     360

ggtgacggtg ataagaaggg gaatgcagag ggcagcagcg acgaggaagg gaagctggtc     420

attgatgagc cagccaagga gaagaacgag aaaggagcgt tgaatcagca agcaggggac     480

ttgctggagg actctcctaa tcgtcccaat gaggcagaaa accctgaagg agaggagaag     540

gaggcagcca ccttggaggt tgagaggccc cttcctatgg aggtggaaaa gaatagcacc     600

ccctctgagc ccggctctgg ccgggggcct ccccaagagg aagaagaaga ggaggatgaa     660

gaggaagagg ctaccaagga agatgctgag gccccaggca tcagagatca tgagagcctg     720

agtgagctgc agaacaagct ggaagagttg gatctggact cgtacaag                  768


