                         SEQUENCE LISTING

<110>  IO Biotech ApS
 
<120>  COMBINATION THERAPY FOR CANCER

<130>  N421330WO

<150>  GB 2103673.6
<151>  2021-03-17

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala His Ala Met Glu Asn Ser Trp Thr Ile Ser Lys Glu Tyr His 
1               5                   10                  15      


Ile Asp Glu Glu Val Gly Phe Ala Leu Pro Asn Pro Gln Glu Asn Leu 
            20                  25                  30          


Pro Asp Phe Tyr Asn Asp Trp Met Phe Ile Ala Lys His Leu Pro Asp 
        35                  40                  45              


Leu Ile Glu Ser Gly Gln Leu Arg Glu Arg Val Glu Lys Leu Asn Met 
    50                  55                  60                  


Leu Ser Ile Asp His Leu Thr Asp His Lys Ser Gln Arg Leu Ala Arg 
65                  70                  75                  80  


Leu Val Leu Gly Cys Ile Thr Met Ala Tyr Val Trp Gly Lys Gly His 
                85                  90                  95      


Gly Asp Val Arg Lys Val Leu Pro Arg Asn Ile Ala Val Pro Tyr Cys 
            100                 105                 110         


Gln Leu Ser Lys Lys Leu Glu Leu Pro Pro Ile Leu Val Tyr Ala Asp 
        115                 120                 125             


Cys Val Leu Ala Asn Trp Lys Lys Lys Asp Pro Asn Lys Pro Leu Thr 
    130                 135                 140                 


Tyr Glu Asn Met Asp Val Leu Phe Ser Phe Arg Asp Gly Asp Cys Ser 
145                 150                 155                 160 


Lys Gly Phe Phe Leu Val Ser Leu Leu Val Glu Ile Ala Ala Ala Ser 
                165                 170                 175     


Ala Ile Lys Val Ile Pro Thr Val Phe Lys Ala Met Gln Met Gln Glu 
            180                 185                 190         


Arg Asp Thr Leu Leu Lys Ala Leu Leu Glu Ile Ala Ser Cys Leu Glu 
        195                 200                 205             


Lys Ala Leu Gln Val Phe His Gln Ile His Asp His Val Asn Pro Lys 
    210                 215                 220                 


Ala Phe Phe Ser Val Leu Arg Ile Tyr Leu Ser Gly Trp Lys Gly Asn 
225                 230                 235                 240 


Pro Gln Leu Ser Asp Gly Leu Val Tyr Glu Gly Phe Trp Glu Asp Pro 
                245                 250                 255     


Lys Glu Phe Ala Gly Gly Ser Ala Gly Gln Ser Ser Val Phe Gln Cys 
            260                 265                 270         


Phe Asp Val Leu Leu Gly Ile Gln Gln Thr Ala Gly Gly Gly His Ala 
        275                 280                 285             


Ala Gln Phe Leu Gln Asp Met Arg Arg Tyr Met Pro Pro Ala His Arg 
    290                 295                 300                 


Asn Phe Leu Cys Ser Leu Glu Ser Asn Pro Ser Val Arg Glu Phe Val 
305                 310                 315                 320 


Leu Ser Lys Gly Asp Ala Gly Leu Arg Glu Ala Tyr Asp Ala Cys Val 
                325                 330                 335     


Lys Ala Leu Val Ser Leu Arg Ser Tyr His Leu Gln Ile Val Thr Lys 
            340                 345                 350         


Tyr Ile Leu Ile Pro Ala Ser Gln Gln Pro Lys Glu Asn Lys Thr Ser 
        355                 360                 365             


Glu Asp Pro Ser Lys Leu Glu Ala Lys Gly Thr Gly Gly Thr Asp Leu 
    370                 375                 380                 


Met Asn Phe Leu Lys Thr Val Arg Ser Thr Thr Glu Lys Ser Leu Leu 
385                 390                 395                 400 


Lys Glu Gly 
            


<210>  2
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Leu Leu Glu Ile Ala Ser Cys Leu 
1               5                   


<210>  3
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  3

Asp Thr Leu Leu Lys Ala Leu Leu Glu Ile Ala Ser Cys Leu Glu Lys 
1               5                   10                  15      


Ala Leu Gln Val Phe 
            20      


<210>  4
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  4

Gln Leu Arg Glu Arg Val Glu Lys Leu 
1               5                   


<210>  5
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  5

Phe Leu Val Ser Leu Leu Val Glu Ile 
1               5                   


<210>  6
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  6

Thr Leu Leu Lys Ala Leu Leu Glu Ile 
1               5                   


<210>  7
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  7

Phe Ile Ala Lys His Leu Pro Asp Leu 
1               5                   


<210>  8
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  8

Val Leu Ser Lys Gly Asp Ala Gly Leu 
1               5                   


<210>  9
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  9

Asp Leu Met Asn Phe Leu Lys Thr Val 
1               5                   


<210>  10
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  10

Val Leu Leu Gly Ile Gln Gln Thr Ala 
1               5                   


<210>  11
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  11

Lys Val Leu Pro Arg Asn Ile Ala Val 
1               5                   


<210>  12
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  12

Lys Leu Asn Met Leu Ser Ile Asp His Leu 
1               5                   10  


<210>  13
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  13

Ser Leu Arg Ser Tyr His Leu Gln Ile Val 
1               5                   10  


<210>  14
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  15
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  15

Leu Leu Asn Ala Phe Thr Val Thr Val 
1               5                   


<210>  16
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  16

Ile Leu Leu Cys Leu Gly Val Ala Leu 
1               5                   


<210>  17
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  17

Ile Leu Gly Ala Ile Leu Leu Cys Leu 
1               5                   


<210>  18
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  18

Ala Leu Gln Ile Thr Asp Val Lys Leu 
1               5                   


<210>  19
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  19

Lys Leu Phe Asn Val Thr Ser Thr Leu 
1               5                   


<210>  20
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  20

Arg Leu Leu Lys Asp Gln Leu Ser Leu 
1               5                   


<210>  21
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  21

Gln Leu Ser Leu Gly Asn Ala Ala Leu 
1               5                   


<210>  22
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  22

Lys Ile Asn Gln Arg Ile Leu Val Val 
1               5                   


<210>  23
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  23

His Leu Val Ile Leu Gly Ala Ile Leu 
1               5                   


<210>  24
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  24

Arg Ile Asn Thr Thr Thr Asn Glu Ile 
1               5                   


<210>  25
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  25

Cys Leu Gly Val Ala Leu Thr Phe Ile 
1               5                   


<210>  26
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  26

Gln Leu Asp Leu Ala Ala Leu Ile Val 
1               5                   


<210>  27
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  27

Ser Leu Gly Asn Ala Ala Leu Gln Ile 
1               5                   


<210>  28
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  28

Val Ile Leu Gly Ala Ile Leu Leu Cys Leu 
1               5                   10  


<210>  29
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  29

His Thr Ala Glu Leu Val Ile Pro Glu Leu 
1               5                   10  


<210>  30
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  30

Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10  


<210>  31
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  31

Val Ile Trp Thr Ser Ser Asp His Gln Val 
1               5                   10  


<210>  32
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  32

Phe Met Thr Tyr Trp His Leu Leu Asn Ala Phe Thr Val Thr Val Pro 
1               5                   10                  15      


Lys Asp Leu 
            


<210>  33
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PD-L1 siRNA duplex sense sequence

<400>  33
ccuacuggca uuugcugaac gcauu                                             25


<210>  34
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PD-L1 siRNA duplex antisense sequence

<400>  34
aaugcguuca gcaaaugcca guagg                                             25


<210>  35
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IDO siRNA duplex - siRNA1 sense sequence

<400>  35
acaucugccu gaucucauat t                                                 21


<210>  36
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IDO siRNA duplex - siRNA1 antisense sequence

<400>  36
uaugagauca ggcagaugut t                                                 21


<210>  37
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IDO siRNA duplex - siRNA2 sense sequence

<400>  37
ccacgaucau gugaacccat t                                                 21


<210>  38
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IDO siRNA duplex - siRNA2 antisense sequence

<400>  38
uggguucaca ugaucgugga t                                                 21


<210>  39
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IDO siRNA duplex - siRNA3 sense sequence

<400>  39
cgaucaugug aacccaaaat t                                                 21


<210>  40
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IDO siRNA duplex - siRNA3 antisense sequence

<400>  40
uuuuggguuc acaugaucgt g                                                 21


