                         SEQUENCE LISTING

<110>  ҩ＼оԺ޹˾
             Valin＼޹˾
             ڸǷ＼о
 
<120>  һIL-17RAFcںϵ׼;

<130>  UP-216012-5952

<150>  CN2022106933810

<151>  2022-06-17

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  288
<212>  PRT
<213>  ˹Уartificial sequence

<400>  1

Leu Arg Leu Leu Asp His Arg Ala Leu Val Cys Ser Gln Pro Gly Leu 
1               5                   10                  15      


Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His 
            20                  25                  30          


Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu 
        35                  40                  45              


His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile 
    50                  55                  60                  


Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala 
65                  70                  75                  80  


Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Arg 
                85                  90                  95      


Phe Glu Phe Leu Ser Lys Leu Arg His His His Lys Arg Trp Arg Phe 
            100                 105                 110         


Thr Phe Ser His Phe Val Val Asp Pro Gly Gln Glu Tyr Glu Val Thr 
        115                 120                 125             


Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Gln 
    130                 135                 140                 


Ser Lys Asn Phe Leu Val Pro Asp Cys Glu Asp Ala Arg Met Lys Val 
145                 150                 155                 160 


Thr Thr Pro Cys Met Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile Thr 
                165                 170                 175     


Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser Phe Thr Leu Trp 
            180                 185                 190         


Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser Phe Pro His Met 
        195                 200                 205             


Glu Asn His Ser Cys Phe Glu His Met His His Ile Pro Ala Pro Arg 
    210                 215                 220                 


Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu Thr Leu Arg Asn 
225                 230                 235                 240 


Leu Lys Gly Cys Cys Arg His Gln Val Gln Ile Gln Pro Phe Phe Ser 
                245                 250                 255     


Ser Cys Leu Asn Asp Cys Leu Arg His Ser Ala Thr Val Ser Cys Pro 
            260                 265                 270         


Glu Met Pro Asp Thr Pro Glu Pro Ile Pro Asp Tyr Met Pro Leu Trp 
        275                 280                 285             


<210>  2
<211>  288
<212>  PRT
<213>  ˹Уartificial sequence

<400>  2

Leu Arg Leu Leu Asp His Arg Ala Pro Val Cys Ser Gln Pro Gly Leu 
1               5                   10                  15      


Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His 
            20                  25                  30          


Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu 
        35                  40                  45              


His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile 
    50                  55                  60                  


Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala 
65                  70                  75                  80  


Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Arg 
                85                  90                  95      


Phe Glu Phe Leu Ser Lys Leu Arg His His His Lys Arg Trp Arg Phe 
            100                 105                 110         


Thr Phe Ser His Phe Val Val Asp Pro Gly Gln Glu Tyr Glu Val Thr 
        115                 120                 125             


Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Gln 
    130                 135                 140                 


Ser Lys Asn Phe Leu Val Pro Asp Cys Glu Asp Ala Arg Met Lys Val 
145                 150                 155                 160 


Thr Thr Pro Cys Met Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile Thr 
                165                 170                 175     


Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser Phe Thr Leu Trp 
            180                 185                 190         


Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser Phe Pro His Met 
        195                 200                 205             


Glu Asn His Ser Cys Phe Glu His Met His His Ile Pro Ala Pro Arg 
    210                 215                 220                 


Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu Thr Leu Arg Asn 
225                 230                 235                 240 


Leu Lys Gly Cys Cys Arg His Gln Val Gln Ile Gln Pro Phe Phe Ser 
                245                 250                 255     


Ser Cys Leu Asn Asp Cys Leu Arg His Ser Ala Thr Val Ser Cys Pro 
            260                 265                 270         


Glu Met Pro Asp Thr Pro Glu Pro Ile Pro Asp Tyr Met Pro Leu Trp 
        275                 280                 285             


<210>  3
<211>  288
<212>  PRT
<213>  ˹Уartificial sequence

<400>  3

Leu Arg Leu Leu Asp His Arg Ala Pro Val Cys Ser Gln Pro Gly Leu 
1               5                   10                  15      


Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His 
            20                  25                  30          


Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu 
        35                  40                  45              


His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile 
    50                  55                  60                  


Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala 
65                  70                  75                  80  


Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Arg 
                85                  90                  95      


Phe Glu Phe Leu Ser Lys Leu Arg His His His Lys Arg Trp Arg Phe 
            100                 105                 110         


Thr Phe Ser His Phe Val Val Asp Pro Gly Gln Glu Tyr Glu Val Thr 
        115                 120                 125             


Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Gln 
    130                 135                 140                 


Ser Lys Asn Phe Leu Val Pro Asp Cys Glu Asp Ala Arg Met Lys Val 
145                 150                 155                 160 


Thr Thr Pro Cys Met Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile Thr 
                165                 170                 175     


Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser Phe Thr Leu Trp 
            180                 185                 190         


Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser Phe Pro His Met 
        195                 200                 205             


Glu Asn His Ser Cys Phe Glu His Met His His Ile Pro Ala Pro Arg 
    210                 215                 220                 


Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu Thr Leu Arg Asn 
225                 230                 235                 240 


Leu Lys Trp Cys Cys Arg His Gln Val Gln Ile Gln Pro Phe Phe Ser 
                245                 250                 255     


Ser Cys Leu Asn Asp Cys Leu Arg His Ser Val Thr Val Ser Cys Pro 
            260                 265                 270         


Glu Met Pro Asp Thr Pro Glu Pro Ile Pro Asp Tyr Met Pro Leu Trp 
        275                 280                 285             


<210>  4
<211>  231
<212>  PRT
<213>  ˹Уartificial sequence

<400>  4

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
            100                 105                 110         


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Gly Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys 
225                 230     


<210>  5
<211>  32
<212>  PRT
<213>  ˣHomo sapiens

<400>  5

Met Gly Ala Ala Arg Ser Pro Pro Ser Ala Val Pro Gly Pro Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Leu Leu Leu Gly Val Leu Ala Pro Gly Gly Ala Ser 
            20                  25                  30          


<210>  6
<211>  554
<212>  PRT
<213>  ˹Уartificial sequence

<400>  6

Met Gly Ala Ala Arg Ser Pro Pro Ser Ala Val Pro Gly Pro Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Leu Leu Leu Gly Val Leu Ala Pro Gly Gly Ala Ser 
            20                  25                  30          


Leu Arg Leu Leu Asp His Arg Ala Leu Val Cys Ser Gln Pro Gly Leu 
        35                  40                  45              


Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His 
    50                  55                  60                  


Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu 
65                  70                  75                  80  


His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile 
                85                  90                  95      


Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala 
            100                 105                 110         


Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Arg 
        115                 120                 125             


Phe Glu Phe Leu Ser Lys Leu Arg His His His Lys Arg Trp Arg Phe 
    130                 135                 140                 


Thr Phe Ser His Phe Val Val Asp Pro Gly Gln Glu Tyr Glu Val Thr 
145                 150                 155                 160 


Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Gln 
                165                 170                 175     


Ser Lys Asn Phe Leu Val Pro Asp Cys Glu Asp Ala Arg Met Lys Val 
            180                 185                 190         


Thr Thr Pro Cys Met Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile Thr 
        195                 200                 205             


Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser Phe Thr Leu Trp 
    210                 215                 220                 


Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser Phe Pro His Met 
225                 230                 235                 240 


Glu Asn His Ser Cys Phe Glu His Met His His Ile Pro Ala Pro Arg 
                245                 250                 255     


Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu Thr Leu Arg Asn 
            260                 265                 270         


Leu Lys Gly Cys Cys Arg His Gln Val Gln Ile Gln Pro Phe Phe Ser 
        275                 280                 285             


Ser Cys Leu Asn Asp Cys Leu Arg His Ser Ala Thr Val Ser Cys Pro 
    290                 295                 300                 


Glu Met Pro Asp Thr Pro Glu Pro Ile Pro Asp Tyr Met Pro Leu Trp 
305                 310                 315                 320 


Gly Ser Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                325                 330                 335     


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
            340                 345                 350         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        355                 360                 365             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    370                 375                 380                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
385                 390                 395                 400 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                405                 410                 415     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            420                 425                 430         


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        435                 440                 445             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    450                 455                 460                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
465                 470                 475                 480 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                485                 490                 495     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            500                 505                 510         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        515                 520                 525             


Val Phe Ser Cys Ser Val Met His Glu Gly Leu His Asn His Tyr Thr 
    530                 535                 540                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 


<210>  7
<211>  554
<212>  PRT
<213>  ˹Уartificial sequence

<400>  7

Met Gly Ala Ala Arg Ser Pro Pro Ser Ala Val Pro Gly Pro Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Leu Leu Leu Gly Val Leu Ala Pro Gly Gly Ala Ser 
            20                  25                  30          


Leu Arg Leu Leu Asp His Arg Ala Pro Val Cys Ser Gln Pro Gly Leu 
        35                  40                  45              


Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His 
    50                  55                  60                  


Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu 
65                  70                  75                  80  


His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile 
                85                  90                  95      


Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala 
            100                 105                 110         


Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Arg 
        115                 120                 125             


Phe Glu Phe Leu Ser Lys Leu Arg His His His Lys Arg Trp Arg Phe 
    130                 135                 140                 


Thr Phe Ser His Phe Val Val Asp Pro Gly Gln Glu Tyr Glu Val Thr 
145                 150                 155                 160 


Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Gln 
                165                 170                 175     


Ser Lys Asn Phe Leu Val Pro Asp Cys Glu Asp Ala Arg Met Lys Val 
            180                 185                 190         


Thr Thr Pro Cys Met Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile Thr 
        195                 200                 205             


Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser Phe Thr Leu Trp 
    210                 215                 220                 


Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser Phe Pro His Met 
225                 230                 235                 240 


Glu Asn His Ser Cys Phe Glu His Met His His Ile Pro Ala Pro Arg 
                245                 250                 255     


Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu Thr Leu Arg Asn 
            260                 265                 270         


Leu Lys Gly Cys Cys Arg His Gln Val Gln Ile Gln Pro Phe Phe Ser 
        275                 280                 285             


Ser Cys Leu Asn Asp Cys Leu Arg His Ser Ala Thr Val Ser Cys Pro 
    290                 295                 300                 


Glu Met Pro Asp Thr Pro Glu Pro Ile Pro Asp Tyr Met Pro Leu Trp 
305                 310                 315                 320 


Gly Ser Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                325                 330                 335     


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
            340                 345                 350         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        355                 360                 365             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    370                 375                 380                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
385                 390                 395                 400 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                405                 410                 415     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            420                 425                 430         


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        435                 440                 445             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    450                 455                 460                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
465                 470                 475                 480 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                485                 490                 495     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            500                 505                 510         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        515                 520                 525             


Val Phe Ser Cys Ser Val Met His Glu Gly Leu His Asn His Tyr Thr 
    530                 535                 540                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 


<210>  8
<211>  554
<212>  PRT
<213>  ˹Уartificial sequence

<400>  8

Met Gly Ala Ala Arg Ser Pro Pro Ser Ala Val Pro Gly Pro Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Leu Leu Leu Gly Val Leu Ala Pro Gly Gly Ala Ser 
            20                  25                  30          


Leu Arg Leu Leu Asp His Arg Ala Pro Val Cys Ser Gln Pro Gly Leu 
        35                  40                  45              


Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His 
    50                  55                  60                  


Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu 
65                  70                  75                  80  


His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile 
                85                  90                  95      


Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala 
            100                 105                 110         


Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Arg 
        115                 120                 125             


Phe Glu Phe Leu Ser Lys Leu Arg His His His Lys Arg Trp Arg Phe 
    130                 135                 140                 


Thr Phe Ser His Phe Val Val Asp Pro Gly Gln Glu Tyr Glu Val Thr 
145                 150                 155                 160 


Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Gln 
                165                 170                 175     


Ser Lys Asn Phe Leu Val Pro Asp Cys Glu Asp Ala Arg Met Lys Val 
            180                 185                 190         


Thr Thr Pro Cys Met Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile Thr 
        195                 200                 205             


Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser Phe Thr Leu Trp 
    210                 215                 220                 


Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser Phe Pro His Met 
225                 230                 235                 240 


Glu Asn His Ser Cys Phe Glu His Met His His Ile Pro Ala Pro Arg 
                245                 250                 255     


Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu Thr Leu Arg Asn 
            260                 265                 270         


Leu Lys Trp Cys Cys Arg His Gln Val Gln Ile Gln Pro Phe Phe Ser 
        275                 280                 285             


Ser Cys Leu Asn Asp Cys Leu Arg His Ser Val Thr Val Ser Cys Pro 
    290                 295                 300                 


Glu Met Pro Asp Thr Pro Glu Pro Ile Pro Asp Tyr Met Pro Leu Trp 
305                 310                 315                 320 


Gly Ser Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                325                 330                 335     


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
            340                 345                 350         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        355                 360                 365             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    370                 375                 380                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
385                 390                 395                 400 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                405                 410                 415     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            420                 425                 430         


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        435                 440                 445             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    450                 455                 460                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
465                 470                 475                 480 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                485                 490                 495     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            500                 505                 510         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        515                 520                 525             


Val Phe Ser Cys Ser Val Met His Glu Gly Leu His Asn His Tyr Thr 
    530                 535                 540                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 


<210>  9
<211>  864
<212>  DNA
<213>  ˹Уartificial sequence

<400>  9
ctgagactgc tggaccacag agccctggtc tgctcccagc ccggcctgaa ctgcaccgtg       60

aagaactcta cctgcctgga cgactcctgg atccaccccc ggaacctgac cccctccagc      120

cccaaggacc tgcagatcca gctgcacttc gcccacaccc agcagggcga cctgttcccc      180

gtggcccaca tcgagtggac cctgcagacc gacgcctcca tcctgtacct ggaaggcgcc      240

gagctgtccg tgctgcagct gaacaccaac gagcggctgt gcgtgcgctt cgagttcctg      300

tccaagctgc ggcaccacca caagcggtgg cggttcacct tctcccactt cgtggtggac      360

cccggccagg aatacgaagt gaccgtgcac catctgccca agcccatccc cgacggcgac      420

cccaaccacc agtccaagaa ctttctggtg cccgactgcg aggacgcccg gatgaaggtc      480

acaaccccct gcatgtcctc cggctccctg tgggacccca acatcaccgt ggaaaccctg      540

gaagcccacc agctgcgggt gtccttcacc ctgtggaacg agtccaccca ctaccagatc      600

ctgctgacct ccttccccca catggaaaac cacagctgct tcgagcacat gcaccacatc      660

cctgcccctc ggcccgagga attccaccag cggtccaacg tgaccctgac cctgcggaac      720

ctgaagggct gctgccggca ccaggtgcag attcagccct tcttctcctc ttgcctgaac      780

gactgcctgc ggcactccgc caccgtgtcc tgccctgaga tgcccgacac ccccgagccc      840

atccctgact acatgcctct gtgg                                 864


<210>  10
<211>  864
<212>  DNA
<213>  ˹Уartificial sequence

<400>  10
ctgagactgc tggaccacag agcccccgtc tgctcccagc ccggcctgaa ctgcaccgtg       60

aagaactcta cctgcctgga cgactcctgg atccaccccc ggaacctgac cccctccagc      120

cccaaggacc tgcagatcca gctgcacttc gcccacaccc agcagggcga cctgttcccc      180

gtggcccaca tcgagtggac cctgcagacc gacgcctcca tcctgtacct ggaaggcgcc      240

gagctgtccg tgctgcagct gaacaccaac gagcggctgt gcgtgcgctt cgagttcctg      300

tccaagctgc ggcaccacca caagcggtgg cggttcacct tctcccactt cgtggtggac      360

cccggccagg aatacgaagt gaccgtgcac catctgccca agcccatccc cgacggcgac      420

cccaaccacc agtccaagaa ctttctggtg cccgactgcg aggacgcccg gatgaaggtc      480

acaaccccct gcatgtcctc cggctccctg tgggacccca acatcaccgt ggaaaccctg      540

gaagcccacc agctgcgggt gtccttcacc ctgtggaacg agtccaccca ctaccagatc      600

ctgctgacct ccttccccca catggaaaac cacagctgct tcgagcacat gcaccacatc      660

cctgcccctc ggcccgagga attccaccag cggtccaacg tgaccctgac cctgcggaac      720

ctgaagggct gctgccggca ccaggtgcag attcagccct tcttctcctc ttgcctgaac      780

gactgcctgc ggcactccgc caccgtgtcc tgccctgaga tgcccgacac ccccgagccc      840

atccctgact acatgcctct gtgg                                   864


<210>  11
<211>  864
<212>  DNA
<213>  ˹Уartificial sequence

<400>  11
ctgagactgc tggaccacag agcccccgtc tgctcccagc ccggcctgaa ctgcaccgtg       60

aagaactcta cctgcctgga cgactcctgg atccaccccc ggaacctgac cccctccagc      120

cccaaggacc tgcagatcca gctgcacttc gcccacaccc agcagggcga cctgttcccc      180

gtggcccaca tcgagtggac cctgcagacc gacgcctcca tcctgtacct ggaaggcgcc      240

gagctgtccg tgctgcagct gaacaccaac gagcggctgt gcgtgcgctt cgagttcctg      300

tccaagctgc ggcaccacca caagcggtgg cggttcacct tctcccactt cgtggtggac      360

cccggccagg aatacgaagt gaccgtgcac catctgccca agcccatccc cgacggcgac      420

cccaaccacc agtccaagaa ctttctggtg cccgactgcg aggacgcccg gatgaaggtc      480

acaaccccct gcatgtcctc cggctccctg tgggacccca acatcaccgt ggaaaccctg      540

gaagcccacc agctgcgggt gtccttcacc ctgtggaacg agtccaccca ctaccagatc      600

ctgctgacct ccttccccca catggaaaac cacagctgct tcgagcacat gcaccacatc      660

cctgcccctc ggcccgagga attccaccag cggtccaacg tgaccctgac cctgcggaac      720

ctgaagtggt gctgccggca ccaggtgcag attcagccct tcttctcctc ttgcctgaac      780

gactgcctgc ggcactccgt gaccgtgtcc tgccctgaga tgcccgacac ccccgagccc      840

atccctgact acatgcctct gtgg                                                                          864


<210>  12
<211>  693
<212>  DNA
<213>  ˹Уartificial sequence

<400>  12
gagcccaagt cctccgacaa gacccacacc tgtcccccct gccctgctcc tcctgtggct       60

gggccctccg tgttcctgtt ccccccaaag cccaaggaca ccctgatgat ctcccggacc      120

cccgaagtga cctgcgtggt ggtggacgtg tcccacgagg accctgaagt gaagttcaat      180

tggtacgtgg acggcgtgga agtgcacaac gccaagacca agcccagaga ggaacagtac      240

aactccacct accgggtggt gtctgtgctg acagtgctgc accaggactg gctgaacggc      300

aaagagtaca agtgcaaggt gtccaacaag ggcctgccct ccagcatcga aaagaccatc      360

tccaaggcca agggccagcc ccgcgagccc caggtgtaca ccctgccccc tagccgggac      420

gagctgacca agaaccaggt gtccctgacc tgcctggtga aaggcttcta cccctccgat      480

atcgccgtgg aatgggagtc caacggccag cccgagaaca actacaagac caccccccct      540

gtgctggact ccgacggctc attcttcctg tactccaagc tgaccgtgga caagtcccgg      600

tggcagcagg gcaacgtgtt ctcctgctcc gtgatgcacg agggcctgca caaccactac      660

acccagaagt ccctgtccct gagccccggg aaa                                   693


<210>  13
<211>  96
<212>  DNA
<213>  ˣHomo sapiens

<400>  13
atgggcgctg ccagatctcc cccttctgct gtgcctggac ctctgctggg cctccttctg       60

ctgctgctgg gagtgctggc tcctggcggc gctagc                                 96


<210>  14
<211>  1662
<212>  DNA
<213>  ˹Уartificial sequence

<400>  14
atgggcgctg ccagatctcc cccttctgct gtgcctggac ctctgctggg cctccttctg       60

ctgctgctgg gagtgctggc tcctggcggc gctagcctga gactgctgga ccacagagcc      120

ctggtctgct cccagcccgg cctgaactgc accgtgaaga actctacctg cctggacgac      180

tcctggatcc acccccggaa cctgaccccc tccagcccca aggacctgca gatccagctg      240

cacttcgccc acacccagca gggcgacctg ttccccgtgg cccacatcga gtggaccctg      300

cagaccgacg cctccatcct gtacctggaa ggcgccgagc tgtccgtgct gcagctgaac      360

accaacgagc ggctgtgcgt gcgcttcgag ttcctgtcca agctgcggca ccaccacaag      420

cggtggcggt tcaccttctc ccacttcgtg gtggaccccg gccaggaata cgaagtgacc      480

gtgcaccatc tgcccaagcc catccccgac ggcgacccca accaccagtc caagaacttt      540

ctggtgcccg actgcgagga cgcccggatg aaggtcacaa ccccctgcat gtcctccggc      600

tccctgtggg accccaacat caccgtggaa accctggaag cccaccagct gcgggtgtcc      660

ttcaccctgt ggaacgagtc cacccactac cagatcctgc tgacctcctt cccccacatg      720

gaaaaccaca gctgcttcga gcacatgcac cacatccctg cccctcggcc cgaggaattc      780

caccagcggt ccaacgtgac cctgaccctg cggaacctga agggctgctg ccggcaccag      840

gtgcagattc agcccttctt ctcctcttgc ctgaacgact gcctgcggca ctccgccacc      900

gtgtcctgcc ctgagatgcc cgacaccccc gagcccatcc ctgactacat gcctctgtgg      960

ggctccggcg agcccaagtc ctccgacaag acccacacct gtcccccctg ccctgctcct     1020

cctgtggctg ggccctccgt gttcctgttc cccccaaagc ccaaggacac cctgatgatc     1080

tcccggaccc ccgaagtgac ctgcgtggtg gtggacgtgt cccacgagga ccctgaagtg     1140

aagttcaatt ggtacgtgga cggcgtggaa gtgcacaacg ccaagaccaa gcccagagag     1200

gaacagtaca actccaccta ccgggtggtg tctgtgctga cagtgctgca ccaggactgg     1260

ctgaacggca aagagtacaa gtgcaaggtg tccaacaagg gcctgccctc cagcatcgaa     1320

aagaccatct ccaaggccaa gggccagccc cgcgagcccc aggtgtacac cctgccccct     1380

agccgggacg agctgaccaa gaaccaggtg tccctgacct gcctggtgaa aggcttctac     1440

ccctccgata tcgccgtgga atgggagtcc aacggccagc ccgagaacaa ctacaagacc     1500

accccccctg tgctggactc cgacggctca ttcttcctgt actccaagct gaccgtggac     1560

aagtcccggt ggcagcaggg caacgtgttc tcctgctccg tgatgcacga gggcctgcac     1620

aaccactaca cccagaagtc cctgtccctg agccccggga aa                        1662


<210>  15
<211>  1662
<212>  DNA
<213>  ˹Уartificial sequence

<400>  15
atgggcgctg ccagatctcc cccttctgct gtgcctggac ctctgctggg cctccttctg       60

ctgctgctgg gagtgctggc tcctggcggc gctagcctga gactgctgga ccacagagcc      120

cccgtctgct cccagcccgg cctgaactgc accgtgaaga actctacctg cctggacgac      180

tcctggatcc acccccggaa cctgaccccc tccagcccca aggacctgca gatccagctg      240

cacttcgccc acacccagca gggcgacctg ttccccgtgg cccacatcga gtggaccctg      300

cagaccgacg cctccatcct gtacctggaa ggcgccgagc tgtccgtgct gcagctgaac      360

accaacgagc ggctgtgcgt gcgcttcgag ttcctgtcca agctgcggca ccaccacaag      420

cggtggcggt tcaccttctc ccacttcgtg gtggaccccg gccaggaata cgaagtgacc      480

gtgcaccatc tgcccaagcc catccccgac ggcgacccca accaccagtc caagaacttt      540

ctggtgcccg actgcgagga cgcccggatg aaggtcacaa ccccctgcat gtcctccggc      600

tccctgtggg accccaacat caccgtggaa accctggaag cccaccagct gcgggtgtcc      660

ttcaccctgt ggaacgagtc cacccactac cagatcctgc tgacctcctt cccccacatg      720

gaaaaccaca gctgcttcga gcacatgcac cacatccctg cccctcggcc cgaggaattc      780

caccagcggt ccaacgtgac cctgaccctg cggaacctga agggctgctg ccggcaccag      840

gtgcagattc agcccttctt ctcctcttgc ctgaacgact gcctgcggca ctccgccacc      900

gtgtcctgcc ctgagatgcc cgacaccccc gagcccatcc ctgactacat gcctctgtgg      960

ggctccggcg agcccaagtc ctccgacaag acccacacct gtcccccctg ccctgctcct     1020

cctgtggctg ggccctccgt gttcctgttc cccccaaagc ccaaggacac cctgatgatc     1080

tcccggaccc ccgaagtgac ctgcgtggtg gtggacgtgt cccacgagga ccctgaagtg     1140

aagttcaatt ggtacgtgga cggcgtggaa gtgcacaacg ccaagaccaa gcccagagag     1200

gaacagtaca actccaccta ccgggtggtg tctgtgctga cagtgctgca ccaggactgg     1260

ctgaacggca aagagtacaa gtgcaaggtg tccaacaagg gcctgccctc cagcatcgaa     1320

aagaccatct ccaaggccaa gggccagccc cgcgagcccc aggtgtacac cctgccccct     1380

agccgggacg agctgaccaa gaaccaggtg tccctgacct gcctggtgaa aggcttctac     1440

ccctccgata tcgccgtgga atgggagtcc aacggccagc ccgagaacaa ctacaagacc     1500

accccccctg tgctggactc cgacggctca ttcttcctgt actccaagct gaccgtggac     1560

aagtcccggt ggcagcaggg caacgtgttc tcctgctccg tgatgcacga gggcctgcac     1620

aaccactaca cccagaagtc cctgtccctg agccccggga aa                        1662


<210>  16
<211>  1662
<212>  DNA
<213>  ˹Уartificial sequence

<400>  16
atgggcgctg ccagatctcc cccttctgct gtgcctggac ctctgctggg cctccttctg       60

ctgctgctgg gagtgctggc tcctggcggc gctagcctga gactgctgga ccacagagcc      120

cccgtctgct cccagcccgg cctgaactgc accgtgaaga actctacctg cctggacgac      180

tcctggatcc acccccggaa cctgaccccc tccagcccca aggacctgca gatccagctg      240

cacttcgccc acacccagca gggcgacctg ttccccgtgg cccacatcga gtggaccctg      300

cagaccgacg cctccatcct gtacctggaa ggcgccgagc tgtccgtgct gcagctgaac      360

accaacgagc ggctgtgcgt gcgcttcgag ttcctgtcca agctgcggca ccaccacaag      420

cggtggcggt tcaccttctc ccacttcgtg gtggaccccg gccaggaata cgaagtgacc      480

gtgcaccatc tgcccaagcc catccccgac ggcgacccca accaccagtc caagaacttt      540

ctggtgcccg actgcgagga cgcccggatg aaggtcacaa ccccctgcat gtcctccggc      600

tccctgtggg accccaacat caccgtggaa accctggaag cccaccagct gcgggtgtcc      660

ttcaccctgt ggaacgagtc cacccactac cagatcctgc tgacctcctt cccccacatg      720

gaaaaccaca gctgcttcga gcacatgcac cacatccctg cccctcggcc cgaggaattc      780

caccagcggt ccaacgtgac cctgaccctg cggaacctga agtggtgctg ccggcaccag      840

gtgcagattc agcccttctt ctcctcttgc ctgaacgact gcctgcggca ctccgtgacc      900

gtgtcctgcc ctgagatgcc cgacaccccc gagcccatcc ctgactacat gcctctgtgg      960

ggctccggcg agcccaagtc ctccgacaag acccacacct gtcccccctg ccctgctcct     1020

cctgtggctg ggccctccgt gttcctgttc cccccaaagc ccaaggacac cctgatgatc     1080

tcccggaccc ccgaagtgac ctgcgtggtg gtggacgtgt cccacgagga ccctgaagtg     1140

aagttcaatt ggtacgtgga cggcgtggaa gtgcacaacg ccaagaccaa gcccagagag     1200

gaacagtaca actccaccta ccgggtggtg tctgtgctga cagtgctgca ccaggactgg     1260

ctgaacggca aagagtacaa gtgcaaggtg tccaacaagg gcctgccctc cagcatcgaa     1320

aagaccatct ccaaggccaa gggccagccc cgcgagcccc aggtgtacac cctgccccct     1380

agccgggacg agctgaccaa gaaccaggtg tccctgacct gcctggtgaa aggcttctac     1440

ccctccgata tcgccgtgga atgggagtcc aacggccagc ccgagaacaa ctacaagacc     1500

accccccctg tgctggactc cgacggctca ttcttcctgt actccaagct gaccgtggac     1560

aagtcccggt ggcagcaggg caacgtgttc tcctgctccg tgatgcacga gggcctgcac     1620

aaccactaca cccagaagtc cctgtccctg agccccggga aa                        1662


<210>  17
<211>  523
<212>  PRT
<213>  ˹Уartificial sequence

<400>  17

Leu Arg Leu Leu Asp His Arg Ala Pro Val Cys Ser Gln Pro Gly Leu 
1               5                   10                  15      


Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His 
            20                  25                  30          


Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu 
        35                  40                  45              


His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile 
    50                  55                  60                  


Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala 
65                  70                  75                  80  


Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Arg 
                85                  90                  95      


Phe Glu Phe Leu Ser Lys Leu Arg His His His Lys Arg Trp Arg Phe 
            100                 105                 110         


Thr Phe Ser His Phe Val Val Asp Pro Gly Gln Glu Tyr Glu Val Thr 
        115                 120                 125             


Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Gln 
    130                 135                 140                 


Ser Lys Asn Phe Leu Val Pro Asp Cys Glu Asp Ala Arg Met Lys Val 
145                 150                 155                 160 


Thr Thr Pro Cys Met Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile Thr 
                165                 170                 175     


Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser Phe Thr Leu Trp 
            180                 185                 190         


Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser Phe Pro His Met 
        195                 200                 205             


Glu Asn His Ser Cys Phe Glu His Met His His Ile Pro Ala Pro Arg 
    210                 215                 220                 


Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu Thr Leu Arg Asn 
225                 230                 235                 240 


Leu Lys Trp Cys Cys Arg His Gln Val Gln Ile Gln Pro Phe Phe Ser 
                245                 250                 255     


Ser Cys Leu Asn Asp Cys Leu Arg His Ser Val Thr Val Ser Cys Pro 
            260                 265                 270         


Glu Met Pro Asp Thr Pro Glu Pro Ile Pro Asp Tyr Met Pro Leu Trp 
        275                 280                 285             


Gly Ser Gly Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    290                 295                 300                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
305                 310                 315                 320 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                325                 330                 335     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            340                 345                 350         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        355                 360                 365             


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    370                 375                 380                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
385                 390                 395                 400 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                405                 410                 415     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            420                 425                 430         


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        435                 440                 445             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    450                 455                 460                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
465                 470                 475                 480 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                485                 490                 495     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            500                 505                 510         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        515                 520             


<210>  18
<211>  213
<212>  PRT
<213>  ˹Уartificial sequence

<400>  18

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  19
<211>  450
<212>  PRT
<213>  ˹Уartificial sequence

<400>  19

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Ala Glu Pro Lys Ser Ser 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Gly Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


