                         б

<110>  ѧ
 
<120>  ڰзε׺ＰƱ

<130>  0198-PA-009 

<160>  99

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PD-L1 (KN035) CDR1

<400>  1

Arg Arg Cys Met Ala 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PD-L1 (KN035) CDR2

<400>  2

Lys Leu Leu Thr Thr Ser Gly Ser Thr Tyr Leu Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PD-L1 (KN035) CDR3

<400>  3

Asp Ser Phe Glu Asp Pro Thr Cys Thr Leu Val Thr Ser Ser Gly Ala 
1               5                   10                  15      


Phe Gln Tyr 
            


<210>  4
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  EGFR (7D12) CDR1

<400>  4

Ser Tyr Gly Met Gly 
1               5   


<210>  5
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  EGFR (7D12) CDR2

<400>  5

Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  EGFR (7D12) CDR3

<400>  6

Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr 
1               5                   10                  15  


<210>  7
<211>  37
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  pET F

<400>  7
gaagctgagt gcggccgcag gaagctgagt tggctgc                                37


<210>  8
<211>  38
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  pET R

<400>  8
ctgcggccgc actcagcttc ctttcgggct ttgttagc                               38


<210>  9
<211>  150
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PD-L1 T110BrC6K

<220>
<221>  misc_feature
<222>  (110)..(110)
<223>  Xaa = 6--

<400>  9

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Lys Met Ser Ser Arg Arg 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val 
        35                  40                  45              


Ala Lys Leu Leu Thr Thr Ser Gly Ser Thr Tyr Leu Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asn Asn Ala Lys Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Ser Phe Glu Asp Pro Thr Cys Thr Leu Val Xaa Ser Ser 
            100                 105                 110         


Gly Ala Phe Gln Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Pro Glu Thr Gly Gly 
    130                 135                 140                 


His His His His His His 
145                 150 


<210>  10
<211>  150
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PD-L1 G113BrC6K

<220>
<221>  misc_feature
<222>  (113)..(113)
<223>  Xaa = 6--

<400>  10

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Lys Met Ser Ser Arg Arg 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val 
        35                  40                  45              


Ala Lys Leu Leu Thr Thr Ser Gly Ser Thr Tyr Leu Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asn Asn Ala Lys Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Ser Phe Glu Asp Pro Thr Cys Thr Leu Val Thr Ser Ser 
            100                 105                 110         


Xaa Ala Phe Gln Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Pro Glu Thr Gly Gly 
    130                 135                 140                 


His His His His His His 
145                 150 


<210>  11
<211>  150
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PD-L1 L108BrC6K

<220>
<221>  misc_feature
<222>  (108)..(108)
<223>  Xaa = 6--  -L-Ұ

<400>  11

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Lys Met Ser Ser Arg Arg 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val 
        35                  40                  45              


Ala Lys Leu Leu Thr Thr Ser Gly Ser Thr Tyr Leu Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asn Asn Ala Lys Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Ser Phe Glu Asp Pro Thr Cys Thr Xaa Val Thr Ser Ser 
            100                 105                 110         


Gly Ala Phe Gln Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Pro Glu Thr Gly Gly 
    130                 135                 140                 


His His His His His His 
145                 150 


<210>  12
<211>  143
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  EGFR Q116FSY

<220>
<221>  misc_feature
<222>  (116)..(116)
<223>  Xaa = -L-Ұ

<400>  12

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Xaa Gly Thr Gln Val Thr Val Ser Ser Ala Gly Gln Gly 
        115                 120                 125             


Thr Ser Gly Leu Pro Glu Thr Gly Gly His His His His His His 
    130                 135                 140             


<210>  13
<211>  128
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PD-L1 aa

<400>  13

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Lys Met Ser Ser Arg Arg 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val 
        35                  40                  45              


Ala Lys Leu Leu Thr Thr Ser Gly Ser Thr Tyr Leu Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asn Asn Ala Lys Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Ser Phe Glu Asp Pro Thr Cys Thr Leu Val Thr Ser Ser 
            100                 105                 110         


Gly Ala Phe Gln Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  14
<211>  150
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PD-L1 (KN035) C-LPETG aa

<400>  14

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Lys Met Ser Ser Arg Arg 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val 
        35                  40                  45              


Ala Lys Leu Leu Thr Thr Ser Gly Ser Thr Tyr Leu Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asn Asn Ala Lys Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Ser Phe Glu Asp Pro Thr Cys Thr Leu Val Thr Ser Ser 
            100                 105                 110         


Gly Ala Phe Gln Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Pro Glu Thr Gly Gly 
    130                 135                 140                 


His His His His His His 
145                 150 


<210>  15
<211>  453
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  PD-L1 (KN035) C-LPETG nt

<400>  15
caagttcagc tgcaagaaag cggtggtggt ctggtgcagc cgggtggtag tctgcgtctg       60

agctgcgcag ccagcggtaa aatgagcagc cgccgctgca tggcttggtt tcgtcaagct      120

ccgggtaaag agcgcgaacg tgtggccaaa ctgctgacca ccagcggtag cacctatctg      180

gccgatagcg tgaaaggccg ctttaccatc agccagaaca acgccaagag caccgtgtat      240

ctgcagatga actctttaaa gccggaagat accgccatgt attactgcgc cgccgatagc      300

tttgaagatc cgacttgtac tttagtgacc agcagtggtg cctttcagta ttggggtcaa      360

ggtacccaag ttaccgtgag cagcggcggt ggtggtagcg gtggtggcgg ttctttaccg      420

gaaaccggcg gccatcatca ccatcatcat taa                                   453


<210>  16
<211>  139
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PD-L1 (KN035) N-GGG aa

<400>  16

Gly Gly Gly Gly Gly Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu 
1               5                   10                  15      


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Lys 
            20                  25                  30          


Met Ser Ser Arg Arg Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys 
        35                  40                  45              


Glu Arg Glu Arg Val Ala Lys Leu Leu Thr Thr Ser Gly Ser Thr Tyr 
    50                  55                  60                  


Leu Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asn Asn Ala 
65                  70                  75                  80  


Lys Ser Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
                85                  90                  95      


Ala Met Tyr Tyr Cys Ala Ala Asp Ser Phe Glu Asp Pro Thr Cys Thr 
            100                 105                 110         


Leu Val Thr Ser Ser Gly Ala Phe Gln Tyr Trp Gly Gln Gly Thr Gln 
        115                 120                 125             


Val Thr Val Ser Ser His His His His His His 
    130                 135                 


<210>  17
<211>  420
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  PD-L1 (KN035) N-GGG nt

<400>  17
ggtggcggcg gtggccaagt tcagctgcaa gaaagcggtg gtggtctggt gcagccgggt       60

ggtagtctgc gtctgagctg cgcagccagc ggtaaaatga gcagccgccg ctgcatggct      120

tggtttcgtc aagctccggg taaagagcgc gaacgtgtgg ccaaactgct gaccaccagc      180

ggtagcacct atctggccga tagcgtgaaa ggccgcttta ccatcagcca gaacaacgcc      240

aagagcaccg tgtatctgca gatgaactct ttaaagccgg aagataccgc catgtattac      300

tgcgccgccg atagctttga agatccgact tgtactttag tgaccagcag tggtgccttt      360

cagtattggg gtcaaggtac ccaagttacc gtgagcagcc atcatcacca tcatcattaa      420


<210>  18
<211>  124
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  EGFR aa

<400>  18

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  19
<211>  143
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  EGFR (7D12) C- LPETG aa

<400>  19

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Gly Gln Gly 
        115                 120                 125             


Thr Ser Gly Leu Pro Glu Thr Gly Gly His His His His His His 
    130                 135                 140             


<210>  20
<211>  432
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  EGFR (7D12) C- LPETG nt

<400>  20
caggtgaaat tagaggaaag cggtggtggc agcgtccaaa cgggtggttc gttgcgctta       60

acgtgtgcgg ccagtggtcg tacaagccgg agctatggga tggggtggtt tcgccaagcc      120

ccaggtaagg aacgcgaatt tgttagtggg atttcgtggc ggggggactc gaccgggtat      180

gccgattcgg ttaaaggccg gttcacgatt tcgcgtgata acgctaagaa taccgtggac      240

ttgcagatga acagtctcaa accggaagat accgctattt attactgcgc ggcggcggcg      300

ggttcggcct ggtatggcac cctgtacgaa tatgattact ggggtcaggg cactcaggtt      360

acggtcagca gtgccggtca gggtacctcc ggtcttccag agacgggcgg acaccaccac      420

caccaccact ga                                                          432


<210>  21
<211>  35
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  pBAD F

<400>  21
agttggctgc tgccaccaga atttgcctgg cggca                                  35


<210>  22
<211>  37
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  pBAD R

<400>  22
gcaggtattt catatggtta attcctcctg ttagccc                                37


<210>  23
<211>  37
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  R32F

<400>  23
gtaaaatgag cagccgctag tgcatggctt ggtttcg                                37


<210>  24
<211>  37
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  R32R

<400>  24
cgaaaccaag ccatgcacta gcggctgctc attttac                                37


<210>  25
<211>  35
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  T54F

<400>  25
ggccaaactg ctgacctaga gcggtagcac ctatc                                  35


<210>  26
<211>  35
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  T54R

<400>  26
gataggtgct accgctctag gtcagcagtt tggcc                                  35


<210>  27
<211>  36
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  D99F

<400>  27
gtattactgc gccgcctaga gctttgaaga tccgac                                 36


<210>  28
<211>  36
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  D99R

<400>  28
gtcggatctt caaagctcta ggcggcgcag taatac                                 36


<210>  29
<211>  37
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  S100F

<400>  29
attactgcgc cgccgattag tttgaagatc cgacttg                                37


<210>  30
<211>  37
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  S100R

<400>  30
caagtcggat cttcaaacta atcggcggcg cagtaat                                37


<210>  31
<211>  36
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  F101F

<400>  31
ctgcgccgcc gatagctagg aagatccgac ttgtac                                 36


<210>  32
<211>  36
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  F101R

<400>  32
gtacaagtcg gatcttccta gctatcggcg gcgcag                                 36


<210>  33
<211>  39
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  E102F

<400>  33
gcgccgccga tagcttttag gatccgactt gtactttag                              39


<210>  34
<211>  39
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  E102R

<400>  34
ctaaagtaca agtcggatcc taaaagctat cggcggcgc                              39


<210>  35
<211>  36
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  D103F

<400>  35
gccgatagct ttgaatagcc gacttgtact ttagtg                                 36


<210>  36
<211>  36
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  D103R

<400>  36
cactaaagta caagtcggct attcaaagct atcggc                                 36


<210>  37
<211>  34
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  P104F

<400>  37
gatagctttg aagattagac ttgtacttta gtga                                   34


<210>  38
<211>  34
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  P104R

<400>  38
tcactaaagt acaagtctaa tcttcaaagc tatc                                   34


<210>  39
<211>  36
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  T105F

<400>  39
tagctttgaa gatccgtagt gtactttagt gaccag                                 36


<210>  40
<211>  36
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  T105R

<400>  40
ctggtcacta aagtacacta cggatcttca aagcta                                 36


<210>  41
<211>  32
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  T107F

<400>  41
gaagatccga cttgttagtt agtgaccagc ag                                     32


<210>  42
<211>  32
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  T107R

<400>  42
ctgctggtca ctaactaaca agtcggatct tc                                     32


<210>  43
<211>  35
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  L108F

<400>  43
agatccgact tgtacttagg tgaccagcag tggtg                                  35


<210>  44
<211>  35
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  L108R

<400>  44
caccactgct ggtcacctaa gtacaagtcg gatct                                  35


<210>  45
<211>  33
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  V109F

<400>  45
ccgacttgta ctttatagac cagcagtggt gcc                                    33


<210>  46
<211>  33
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  V109R

<400>  46
ggcaccactg ctggtctata aagtacaagt cgg                                    33


<210>  47
<211>  35
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  T110F

<400>  47
gacttgtact ttagtgtaga gcagtggtgc ctttc                                  35


<210>  48
<211>  35
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  T110R

<400>  48
gaaaggcacc actgctctac actaaagtac aagtc                                  35


<210>  49
<211>  32
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  S111F

<400>  49
gtactttagt gacctagagt ggtgcctttc ag                                     32


<210>  50
<211>  32
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  S111R

<400>  50
ctgaaaggca ccactctagg tcactaaagt ac                                     32


<210>  51
<211>  35
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  S112F

<400>  51
actttagtga ccagctaggg tgcctttcag tattg                                  35


<210>  52
<211>  35
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  S112R

<400>  52
caatactgaa aggcacccta gctggtcact aaagt                                  35


<210>  53
<211>  38
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  G113F

<400>  53
ctttagtgac cagcagttag gcctttcagt attggggt                               38


<210>  54
<211>  38
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  G113R

<400>  54
accccaatac tgaaaggcct aactgctggt cactaaag                               38


<210>  55
<211>  35
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  A114F

<400>  55
agtgaccagc agtggttagt ttcagtattg gggtc                                  35


<210>  56
<211>  35
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  A114R

<400>  56
gaccccaata ctgaaactaa ccactgctgg tcact                                  35


<210>  57
<211>  33
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  F115F

<400>  57
cagcagtggt gcctagcagt attggggtca agg                                    33


<210>  58
<211>  33
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  F115R

<400>  58
ccttgacccc aatactgcta ggcaccactg ctg                                    33


<210>  59
<211>  34
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  Q116F

<400>  59
gcagtggtgc cttttagtat tggggtcaag gtac                                   34


<210>  60
<211>  34
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  Q116R

<400>  60
gtaccttgac cccaatacta aaaggcacca ctgc                                   34


<210>  61
<211>  35
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  Y117F

<400>  61
cagtggtgcc tttcagtagt ggggtcaagg taccc                                  35


<210>  62
<211>  35
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  Y117R

<400>  62
gggtaccttg accccactac tgaaaggcac cactg                                  35


<210>  63
<211>  4
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LTP

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa Ϊⰱ

<400>  63

Asn Pro Xaa Tyr 
1               


<210>  64
<211>  4
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LTP

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = AlaGly

<400>  64

Asn Pro Xaa Tyr 
1               


<210>  65
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LTP 2

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa Ϊⰱ

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa Ϊⰱ

<400>  65

Phe Xaa Asn Pro Xaa Tyr 
1               5       


<210>  66
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LTP 2

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = AlaGly

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = AlaGly

<400>  66

Phe Xaa Asn Pro Xaa Tyr 
1               5       


<210>  67
<211>  53
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  EGF

<400>  67

Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu His 
1               5                   10                  15      


Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys Asn 
            20                  25                  30          


Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu Lys 
        35                  40                  45              


Trp Trp Glu Leu Arg 
    50              


<210>  68
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  SP

<220>
<221>  MOD-RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  68

Arg Pro Lys Pro Gln Gln Phe Gly Leu Met 
1               5                   10  


<210>  69
<211>  18
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  NY

<220>
<221>  MOD-RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD-RES
<222>  (18)..(18)
<223>  AMIDATION

<400>  69

Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210>  70
<211>  27
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  TP

<400>  70

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  71
<211>  13
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  TAT

<400>  71

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  72
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  pAntp

<400>  72

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  73
<211>  35
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  pHLIP

<400>  73

Ala Glu Gln Asn Pro Ile Tyr Trp Ala Arg Tyr Ala Asp Trp Leu Phe 
1               5                   10                  15      


Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Val Asp Ala Asp 
            20                  25                  30          


Glu Gly Thr 
        35  


<210>  74
<211>  34
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ATRAM

<400>  74

Gly Leu Ala Gly Leu Ala Gly Leu Leu Gly Leu Glu Gly Leu Leu Gly 
1               5                   10                  15      


Leu Pro Leu Gly Leu Leu Glu Gly Leu Trp Leu Gly Leu Glu Leu Glu 
            20                  25                  30          


Gly Asn 
        


<210>  75
<211>  27
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ACPP

<400>  75

Asp Gly Gly Asp Gly Gly Asp Gly Gly Asp Gly Pro Leu Gly Leu Ala 
1               5                   10                  15      


Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg Cys 
            20                  25          


<210>  76
<211>  22
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  pHK-PAS

<400>  76

Met Ile Ala Ser His Leu Leu Ala Tyr Phe Phe Thr Glu Leu Asn Gly 
1               5                   10                  15      


Lys Pro Ile Leu Phe Phe 
            20          


<210>  77
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LTS

<400>  77

Ala Leu Ala Pro Tyr Ile Pro 
1               5           


<210>  78
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  G-CPP

<220>
<221>  misc_feature
<222>  (4)..(12)
<223>  Xaa = DArg

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  78

Gly Gly Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10          


<210>  79
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  G-CPP

<220>
<221>  misc_feature
<222>  (3)..(11)
<223>  Xaa = DArg

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  79

Gly Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10      


<210>  80
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  G-CPP-LTP

<220>
<221>  misc_feature
<222>  (4)..(12)
<223>  Xaa = DArg

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  80

Gly Gly Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asn Pro Gly Tyr 
1               5                   10                  15      


<210>  81
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  G-CPP-LTP

<220>
<221>  misc_feature
<222>  (3)..(11)
<223>  Xaa = DArg

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  AMIDATION

<400>  81

Gly Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asn Pro Gly Tyr 
1               5                   10                  15  


<210>  82
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  G-LTS-CPP

<220>
<221>  misc_feature
<222>  (11)..(19)
<223>  Xaa = DArg

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  AMIDATION

<400>  82

Gly Gly Cys Ala Leu Ala Pro Tyr Ile Pro Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa 
            


<210>  83
<211>  18
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  G-LTS-CPP

<220>
<221>  misc_feature
<222>  (10)..(18)
<223>  Xaa = DArg

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  AMIDATION

<400>  83

Gly Gly Ala Leu Ala Pro Tyr Ile Pro Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa 
        


<210>  84
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CPP-L

<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  Xaa = DArg

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  84

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Leu Pro Glu Thr Gly Gly 
1               5                   10                  15      


<210>  85
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CPP-L

<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  Xaa = DArg

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  AMIDATION

<400>  85

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Pro Glu Thr Gly Gly 
1               5                   10                  15  


<210>  86
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CPP-LTS-L

<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  Xaa = DArg

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  AMIDATION

<400>  86

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Leu Ala Pro Tyr Ile Pro 
1               5                   10                  15      


Cys Leu Pro Glu Thr Gly Gly 
            20              


<210>  87
<211>  22
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CPP-LTS-L

<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  Xaa = DArg

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  AMIDATION

<400>  87

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Leu Ala Pro Tyr Ile Pro 
1               5                   10                  15      


Leu Pro Glu Thr Gly Gly 
            20          


<210>  88
<211>  36
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  G-LTS-CPP-MMP-B

<220>
<221>  misc_feature
<222>  (11)..(19)
<223>  Xaa = DArg

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  88

Gly Gly Cys Ala Leu Ala Pro Tyr Ile Pro Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Pro Leu Gly Leu Ala Gly Gly Asp Gly Gly Asp Gly Gly 
            20                  25                  30          


Asp Gly Gly Asp 
        35      


<210>  89
<211>  35
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  G-LTS-CPP-MMP-B

<220>
<221>  misc_feature
<222>  (10)..(18)
<223>  Xaa = DArg

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  AMIDATION

<400>  89

Gly Gly Ala Leu Ala Pro Tyr Ile Pro Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Pro Leu Gly Leu Ala Gly Gly Asp Gly Gly Asp Gly Gly Asp 
            20                  25                  30          


Gly Gly Asp 
        35  


<210>  90
<211>  40
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  B-MMP-CPP-LTS-L

<220>
<221>  misc_feature
<222>  (18)..(26)
<223>  Xaa = DArg

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  AMIDATION

<400>  90

Asp Gly Gly Asp Gly Gly Asp Gly Gly Asp Gly Pro Leu Gly Leu Ala 
1               5                   10                  15      


Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Leu Ala Pro Tyr Ile 
            20                  25                  30          


Pro Cys Leu Pro Glu Thr Gly Gly 
        35                  40  


<210>  91
<211>  39
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  B-MMP-CPP-LTS-L

<220>
<221>  misc_feature
<222>  (18)..(26)
<223>  Xaa = DArg

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  AMIDATION

<400>  91

Asp Gly Gly Asp Gly Gly Asp Gly Gly Asp Gly Pro Leu Gly Leu Ala 
1               5                   10                  15      


Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Leu Ala Pro Tyr Ile 
            20                  25                  30          


Pro Leu Pro Glu Thr Gly Gly 
        35                  


<210>  92
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Srt A reSEQ

<400>  92

Leu Pro Glu Thr Gly 
1               5   


<210>  93
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Srt A reSEQ 2

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa Ϊⰱ

<400>  93

Leu Pro Xaa Thr Gly 
1               5   


<210>  94
<211>  34
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  NG3-L108F

<400>  94
gatccgacct gtacctaggt taccagcagc ggtg                                   34


<210>  95
<211>  36
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  NG3-L108R

<400>  95
accgctgctg gtaacctagg tacaggtcgg atcttc                                 36


<210>  96
<211>  35
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  NG3-G113F

<400>  96
cctggttacc agcagctagg catttcagta ttggg                                  35


<210>  97
<211>  35
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  NG3-G113R

<400>  97
ccaatactga aatgcctagc tgctggtaac caggg                                  35


<210>  98
<211>  290
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PD-L1

<400>  98

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  99
<211>  181
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Srt A

<400>  99

Lys Pro His Ile Asp Asn Tyr Leu His Asp Lys Asp Lys Asp Glu Lys 
1               5                   10                  15      


Ile Glu Gln Tyr Asp Lys Asn Val Lys Glu Gln Ala Ser Lys Asp Lys 
            20                  25                  30          


Lys Gln Gln Ala Lys Pro Gln Ile Pro Lys Asp Lys Ser Lys Val Ala 
        35                  40                  45              


Gly Tyr Ile Glu Ile Pro Asp Ala Asp Ile Lys Glu Pro Val Tyr Pro 
    50                  55                  60                  


Gly Pro Ala Thr Arg Glu Gln Leu Asn Arg Gly Val Ser Phe Ala Glu 
65                  70                  75                  80  


Glu Asn Glu Ser Leu Asp Asp Gln Asn Ile Ser Ile Ala Gly His Thr 
                85                  90                  95      


Phe Ile Gly Arg Pro Asn Tyr Gln Phe Thr Asn Leu Lys Ala Ala Lys 
            100                 105                 110         


Lys Gly Ser Met Val Tyr Phe Lys Val Gly Asn Glu Thr Arg Lys Tyr 
        115                 120                 125             


Lys Met Thr Ser Ile Arg Asn Val Lys Pro Thr Ala Val Gly Val Leu 
    130                 135                 140                 


Asp Glu Gln Lys Gly Lys Asp Lys Gln Leu Thr Leu Ile Thr Cys Asp 
145                 150                 155                 160 


Asp Leu Asn Arg Glu Thr Gly Val Trp Glu Thr Arg Lys Ile Phe Val 
                165                 170                 175     


Ala Thr Glu Val Lys 
            180     
