                         SEQUENCE LISTING

<110>  H. Lee Moffitt Cancer Center and Research Institute, Inc.
 
<120>  COMPOSITIONS AND METHODS TO REDUCE THERAPEUTIC T CELL TOXICITY

<130>  320803-2800

<150>  US 63/159,222
<151>  2021-03-10

<150>  US 63/209,094
<151>  2021-06-10

<150>  US 63/225,715
<151>  2021-07-26

<160>  71    

<170>  PatentIn version 3.5

<210>  1
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1

Met Ala Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg 
            20                  25                  30          


Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
        35                  40                  45              


Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
65                  70                  75                  80  


Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu 
                85                  90                  95      


Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala 
            100                 105                 110     


<210>  2
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Ala Gly Thr Thr Val Thr Val 
        115                 120 


<210>  3
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr 
        115                 120                 125             


His Thr Cys Pro 
    130         


<210>  4
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  5
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Pro Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met 
        35                  40                  45              


Gly Met Ile Tyr Thr Asp Ile Gly Lys Pro Thr Tyr Ala Glu Glu Phe 
    50                  55                  60                  


Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu 
65                  70                  75                  80  


Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys Val 
                85                  90                  95      


Arg Asp Arg Tyr Asp Ser Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  6
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  7
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7

Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Asp 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Glu Thr Thr Tyr Ser Pro Ala Phe 
    50                  55                  60                  


Gln Gly Asp Val Thr Ile Ser Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Gly Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Gly Asn Tyr Tyr Met Asp Val Trp Gly Asn Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Leu Lys Ser 
        115                 120     


<210>  8
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Arg Ser Thr Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser 
1               5                   10                  15      


Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val 
            20                  25                  30          


Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser 
    50                  55                  60                  


Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile 
65                  70                  75                  80  


Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr 
                85                  90                  95      


Thr Ser Ser Ser Thr Arg His Val Phe Gly Thr Gly Thr Gln Leu Thr 
            100                 105                 110         


Val Leu Gly 
        115 


<210>  9
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala 
        115                 120     


<210>  10
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  11
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Trp Phe Phe Asp Val Trp 
            100                 105                 110         


Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  12
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Asn Tyr Met 
            20                  25                  30          


Asp Trp Tyr Gln Lys Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  13
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be any naturally occurring amino acid

<400>  13

Met Ala Arg Phe Ser Ser Ser Ser Leu Asp Leu Asn Trp Tyr Ser Leu 
1               5                   10                  15      


Gly Leu Gln Xaa Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30          


Tyr Phe Asp Ile Asn Trp Leu Arg Gln Arg Pro Glu Gln Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Val Ile Ser Pro Gly Asp Gly Asn Thr Asn Tyr Asn Glu 
    50                  55                  60                  


Asn Phe Lys Gly Lys Ala Thr Leu Thr Ile Asp Lys Ser Ser Thr Thr 
65                  70                  75                  80  


Ala Tyr Ile Gln Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr 
                85                  90                  95      


Phe Cys Ala Arg Asp Gly Asn Phe Pro Tyr Tyr Ala Met Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Lys 
        115                 120                 125             


Leu 
    


<210>  14
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Asp Ile Val Met Thr Gln Ile Pro Leu Ser Leu Pro Val Ile Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Asn Val Ser Asn Leu Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Ala Asp Ala Ala Ala Ala Gly Ser 
        115                 120 


<210>  15
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Ser Tyr Phe Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ile Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg His Asp Gly Ala Val Ala Gly Leu Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120         


<210>  16
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr 
1               5                   10                  15      


Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His 
            20                  25                  30          


Trp Tyr Gln Gln Pro Pro Gly Gln Ala Pro Val Val Val Val Tyr Asp 
        35                  40                  45              


Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn 
    50                  55                  60                  


Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly Asp 
65                  70                  75                  80  


Glu Ala Val Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His Val 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  17
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Gln Val Ser Cys Arg Ala Ser Gly Tyr Ser Ile Asn Thr Tyr 
            20                  25                  30          


Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Ser Gly Val Thr Ser Tyr Ala Gln Lys Phe Gln 
    50                  55                  60                  


Gly Arg Val Thr Leu Thr Asn Asp Thr Ser Thr Asn Thr Val Tyr Met 
65                  70                  75                  80  


Gln Leu Asn Ser Leu Thr Ser Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp Ala Leu Trp Gly Asp Phe Gly Met Asp Val Trp Gly Lys Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  18
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  19
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Leu His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Tyr 
        35                  40                  45              


Ala Ala Ile Ser Tyr Asp Gly Ser Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Ser Pro Glu Asp Thr Ala Leu Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Trp Phe Val Glu Pro Leu Ser Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  20
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  21
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Phe Leu His Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


<210>  22
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Glu Ile Glu Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Phe Thr Phe Gly Pro Gly Thr Lys Val Glu Ile 
            100                 105                 110 


<210>  23
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  23

Gln Val Gln Leu Val Glu Ser Gly Pro Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Ala Val Ser Gly Phe Ser Val Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Gly Gly Ile Thr Asn Tyr Asn Ser Ala Phe Met 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Ser Arg Gly Gly His Tyr Gly Tyr Ala Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  24
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Glu Ile Val Met Thr Gln Thr Pro Ala Thr Leu Ser Val Ser Ala Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          


Val Thr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Ser Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Glu Phe Thr Phe Thr Ile Ser Ser Val Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Phe Gly 
                85                  90                  95      


Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105 


<210>  25
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  25

Gly Gly Gly Gly Ser 
1               5   


<210>  26
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
1               5                   10          


<210>  27
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  27

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Gly Ser Thr 
            100                 105                 110         


Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr 
                165                 170                 175     


Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly 
    210                 215                 220                 


Gly Asp Gly Phe Tyr Ala Met Asp Val Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Met Ala Asp Ile 
            260                 265                 270         


Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg 
        275                 280                 285             


Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn 
    290                 295                 300                 


Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr 
305                 310                 315                 320 


Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe Ser Gly Ser Gly 
                325                 330                 335     


Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp 
            340                 345                 350         


Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe 
        355                 360                 365             


Ala Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Gln 
385                 390                 395                 400 


Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Met Lys Ile Ser 
                405                 410                 415     


Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val 
            420                 425                 430         


Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met Gly Leu Ile Asn Pro 
        435                 440                 445             


Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr 
    450                 455                 460                 


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser 
465                 470                 475                 480 


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr 
                485                 490                 495     


Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr 
            500                 505                 510         


Val Thr Val 
        515 


<210>  28
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28

Met Ala Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg 
            20                  25                  30          


Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
        35                  40                  45              


Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
65                  70                  75                  80  


Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu 
                85                  90                  95      


Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
    130                 135                 140                 


Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr 
145                 150                 155                 160 


Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met Gly 
                165                 170                 175     


Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys 
            180                 185                 190         


Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
        195                 200                 205             


Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly 
225                 230                 235                 240 


Ala Gly Thr Thr Val Thr Val Glu Pro Lys Ser Cys Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            260                 265                 270         


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
        275                 280                 285             


Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    290                 295                 300                 


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
305                 310                 315                 320 


Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                325                 330                 335     


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 
            340                 345                 350         


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
        355                 360                 365             


Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Glu 
    370                 375                 380                 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
385                 390                 395                 400 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr 
                405                 410                 415     


Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
            420                 425                 430         


Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys 
        435                 440                 445             


Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu 
    450                 455                 460                 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
465                 470                 475                 480 


Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Val Trp Gly Gln Gly 
                485                 490                 495     


Thr Leu Val Thr Val Ser Ser 
            500             


<210>  29
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  29

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Pro Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met 
        35                  40                  45              


Gly Met Ile Tyr Thr Asp Ile Gly Lys Pro Thr Tyr Ala Glu Glu Phe 
    50                  55                  60                  


Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu 
65                  70                  75                  80  


Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys Val 
                85                  90                  95      


Arg Asp Arg Tyr Asp Ser Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro 
    130                 135                 140                 


Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
145                 150                 155                 160 


Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys 
                165                 170                 175     


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 
            180                 185                 190         


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe 
    210                 215                 220                 


Cys Ser Gln Ser Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Met Ala Asp Ile 
            260                 265                 270         


Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg 
        275                 280                 285             


Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn 
    290                 295                 300                 


Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr 
305                 310                 315                 320 


Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe Ser Gly Ser Gly 
                325                 330                 335     


Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp 
            340                 345                 350         


Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe 
        355                 360                 365             


Ala Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Gln 
385                 390                 395                 400 


Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Met Lys Ile Ser 
                405                 410                 415     


Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val 
            420                 425                 430         


Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met Gly Leu Ile Asn Pro 
        435                 440                 445             


Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr 
    450                 455                 460                 


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser 
465                 470                 475                 480 


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr 
                485                 490                 495     


Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr 
            500                 505                 510         


Val Thr Val 
        515 


<210>  30
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  30

Met Ala Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg 
            20                  25                  30          


Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
        35                  40                  45              


Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
65                  70                  75                  80  


Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu 
                85                  90                  95      


Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
    130                 135                 140                 


Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr 
145                 150                 155                 160 


Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met Gly 
                165                 170                 175     


Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys 
            180                 185                 190         


Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
        195                 200                 205             


Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly 
225                 230                 235                 240 


Ala Gly Thr Thr Val Thr Val Glu Pro Lys Ser Cys Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys 
            260                 265                 270         


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        275                 280                 285             


Thr Glu Tyr Pro Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Phe 
    290                 295                 300                 


Lys Trp Met Gly Met Ile Tyr Thr Asp Ile Gly Lys Pro Thr Tyr Ala 
305                 310                 315                 320 


Glu Glu Phe Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr 
                325                 330                 335     


Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr 
            340                 345                 350         


Phe Cys Val Arg Asp Arg Tyr Asp Ser Leu Phe Asp Tyr Trp Gly Gln 
        355                 360                 365             


Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Thr Pro Leu 
385                 390                 395                 400 


Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser 
                405                 410                 415     


Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr 
            420                 425                 430         


Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser 
        435                 440                 445             


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    450                 455                 460                 


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly 
465                 470                 475                 480 


Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro Trp Thr Phe Gly Gly 
                485                 490                 495     


Gly Thr Lys Leu Glu Ile Lys Glu Pro Lys Ser Cys Asp Lys Thr His 
            500                 505                 510         


Thr Cys Pro 
        515 


<210>  31
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  31

Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Asp 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Glu Thr Thr Tyr Ser Pro Ala Phe 
    50                  55                  60                  


Gln Gly Asp Val Thr Ile Ser Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Gly Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Gly Asn Tyr Tyr Met Asp Val Trp Gly Asn Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Leu Lys Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Arg Ser Thr Gln Ser Ala Leu Thr 
    130                 135                 140                 


Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser 
145                 150                 155                 160 


Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp 
                165                 170                 175     


Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp Val 
            180                 185                 190         


Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser 
        195                 200                 205             


Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser Ser Thr Arg His Val 
225                 230                 235                 240 


Phe Gly Thr Gly Thr Gln Leu Thr Val Leu Gly Glu Pro Lys Ser Cys 
                245                 250                 255     


Asp Lys Thr His Thr Cys Pro Glu Pro Lys Ser Cys Asp Lys Thr His 
            260                 265                 270         


Thr Cys Pro Met Ala Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
        275                 280                 285             


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
    290                 295                 300                 


Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
305                 310                 315                 320 


Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro 
                325                 330                 335     


Ser Lys Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
            340                 345                 350         


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
        355                 360                 365             


Asn Thr Leu Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys 
    370                 375                 380                 


Arg Ala Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro 
                405                 410                 415     


Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr 
            420                 425                 430         


Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu 
        435                 440                 445             


Trp Met Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln 
    450                 455                 460                 


Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr 
465                 470                 475                 480 


Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
                485                 490                 495     


Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp 
            500                 505                 510         


Val Trp Gly Ala Gly Thr Thr Val Thr Val 
        515                 520         


<210>  32
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  32

Met Ala Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg 
            20                  25                  30          


Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
        35                  40                  45              


Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
65                  70                  75                  80  


Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu 
                85                  90                  95      


Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
    130                 135                 140                 


Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr 
145                 150                 155                 160 


Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met Gly 
                165                 170                 175     


Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys 
            180                 185                 190         


Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
        195                 200                 205             


Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly 
225                 230                 235                 240 


Ala Gly Thr Thr Val Thr Val Glu Pro Lys Ser Cys Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys 
            260                 265                 270         


Pro Gly Asp Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe 
        275                 280                 285             


Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu 
    290                 295                 300                 


Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Glu Thr Thr Tyr Ser 
305                 310                 315                 320 


Pro Ala Phe Gln Gly Asp Val Thr Ile Ser Val Asp Lys Ser Ile Ser 
                325                 330                 335     


Thr Ala Tyr Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Gly Ile 
            340                 345                 350         


Tyr Tyr Cys Ala Arg Arg Arg Gly Asn Tyr Tyr Met Asp Val Trp Gly 
        355                 360                 365             


Asn Gly Thr Leu Val Thr Val Ser Ser Leu Lys Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Ser Thr Gln Ser 
385                 390                 395                 400 


Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile 
                405                 410                 415     


Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr 
            420                 425                 430         


Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile 
        435                 440                 445             


Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe Ser Gly 
    450                 455                 460                 


Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala 
465                 470                 475                 480 


Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser Ser Thr 
                485                 490                 495     


Arg His Val Phe Gly Thr Gly Thr Gln Leu Thr Val Leu Gly Glu Pro 
            500                 505                 510         


Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
        515                 520         


<210>  33
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  33

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro 
    130                 135                 140                 


Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly 
                165                 170                 175     


Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly 
            180                 185                 190         


Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu 
        195                 200                 205             


Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Met Ala 
                245                 250                 255     


Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
            260                 265                 270         


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
        275                 280                 285             


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
    290                 295                 300                 


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe Ser Gly 
305                 310                 315                 320 


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
                325                 330                 335     


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp 
            340                 345                 350         


Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
    370                 375                 380                 


Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Met Lys 
385                 390                 395                 400 


Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn 
                405                 410                 415     


Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met Gly Leu Ile 
            420                 425                 430         


Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Lys 
        435                 440                 445             


Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu 
    450                 455                 460                 


Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser 
465                 470                 475                 480 


Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Ala Gly 
                485                 490                 495     


Thr Thr Val Thr Val 
            500     


<210>  34
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  34

Met Ala Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg 
            20                  25                  30          


Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
        35                  40                  45              


Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
65                  70                  75                  80  


Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu 
                85                  90                  95      


Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
    130                 135                 140                 


Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr 
145                 150                 155                 160 


Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met Gly 
                165                 170                 175     


Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys 
            180                 185                 190         


Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
        195                 200                 205             


Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly 
225                 230                 235                 240 


Ala Gly Thr Thr Val Thr Val Glu Pro Lys Ser Cys Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys 
            260                 265                 270         


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        275                 280                 285             


Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu 
    290                 295                 300                 


Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn 
305                 310                 315                 320 


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                325                 330                 335     


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            340                 345                 350         


Tyr Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn 
        355                 360                 365             


Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Ser 
385                 390                 395                 400 


Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
                405                 410                 415     


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe Gln Gln 
            420                 425                 430         


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu 
        435                 440                 445             


Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
    450                 455                 460                 


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
465                 470                 475                 480 


Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr 
                485                 490                 495     


Lys Leu Glu Ile Lys 
            500     


<210>  35
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  35

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Trp Phe Phe Asp Val Trp 
            100                 105                 110         


Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Ser Ser Val Asn Tyr Met Asp Trp Tyr Gln Lys Lys Pro 
                165                 170                 175     


Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser 
            180                 185                 190         


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
        195                 200                 205             


Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Met 
                245                 250                 255     


Ala Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu 
            260                 265                 270         


Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn 
        275                 280                 285             


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu 
    290                 295                 300                 


Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe Ser 
305                 310                 315                 320 


Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu 
                325                 330                 335     


Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro 
            340                 345                 350         


Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
    370                 375                 380                 


Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Met 
385                 390                 395                 400 


Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met 
                405                 410                 415     


Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met Gly Leu 
            420                 425                 430         


Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp 
        435                 440                 445             


Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu 
    450                 455                 460                 


Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
465                 470                 475                 480 


Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Ala 
                485                 490                 495     


Gly Thr Thr Val Thr Val 
            500         


<210>  36
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  36

Met Ala Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg 
            20                  25                  30          


Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
        35                  40                  45              


Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
65                  70                  75                  80  


Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu 
                85                  90                  95      


Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
    130                 135                 140                 


Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr 
145                 150                 155                 160 


Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met Gly 
                165                 170                 175     


Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys 
            180                 185                 190         


Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
        195                 200                 205             


Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly 
225                 230                 235                 240 


Ala Gly Thr Thr Val Thr Val Glu Pro Lys Ser Cys Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys 
            260                 265                 270         


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        275                 280                 285             


Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu 
    290                 295                 300                 


Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn 
305                 310                 315                 320 


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                325                 330                 335     


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Asp 
            340                 345                 350         


Tyr Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Trp Phe Phe 
        355                 360                 365             


Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu 
385                 390                 395                 400 


Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr 
                405                 410                 415     


Met Thr Cys Arg Ala Ser Ser Ser Val Asn Tyr Met Asp Trp Tyr Gln 
            420                 425                 430         


Lys Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn 
        435                 440                 445             


Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    450                 455                 460                 


Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr 
465                 470                 475                 480 


Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly Gly Gly 
                485                 490                 495     


Thr Lys Leu Glu Ile Lys 
            500         


<210>  37
<211>  518
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be any naturally occurring amino acid

<400>  37

Met Ala Arg Phe Ser Ser Ser Ser Leu Asp Leu Asn Trp Tyr Ser Leu 
1               5                   10                  15      


Gly Leu Gln Xaa Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30          


Tyr Phe Asp Ile Asn Trp Leu Arg Gln Arg Pro Glu Gln Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Val Ile Ser Pro Gly Asp Gly Asn Thr Asn Tyr Asn Glu 
    50                  55                  60                  


Asn Phe Lys Gly Lys Ala Thr Leu Thr Ile Asp Lys Ser Ser Thr Thr 
65                  70                  75                  80  


Ala Tyr Ile Gln Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr 
                85                  90                  95      


Phe Cys Ala Arg Asp Gly Asn Phe Pro Tyr Tyr Ala Met Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Lys 
        115                 120                 125             


Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Asp Ile Val Met Thr 
    130                 135                 140                 


Gln Ile Pro Leu Ser Leu Pro Val Ile Leu Gly Asp Gln Ala Ser Ile 
145                 150                 155                 160 


Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser Asn Gly Asn Thr Tyr 
                165                 170                 175     


Leu His Trp Phe Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
            180                 185                 190         


Tyr Asn Val Ser Asn Leu Phe Ser Gly Val Pro Asp Arg Phe Ser Gly 
        195                 200                 205             


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
    210                 215                 220                 


Glu Asp Leu Gly Ile Tyr Phe Cys Ser Gln Ser Thr His Val Pro Thr 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Ala 
                245                 250                 255     


Ala Gly Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Met 
            260                 265                 270         


Ala Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu 
        275                 280                 285             


Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn 
    290                 295                 300                 


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu 
305                 310                 315                 320 


Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe Ser 
                325                 330                 335     


Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu 
            340                 345                 350         


Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro 
        355                 360                 365             


Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
385                 390                 395                 400 


Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Met 
                405                 410                 415     


Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met 
            420                 425                 430         


Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met Gly Leu 
        435                 440                 445             


Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp 
    450                 455                 460                 


Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu 
465                 470                 475                 480 


Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
                485                 490                 495     


Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Ala 
            500                 505                 510         


Gly Thr Thr Val Thr Val 
        515             


<210>  38
<211>  518
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<222>  (279)..(279)
<223>  Xaa can be any naturally occurring amino acid

<400>  38

Met Ala Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg 
            20                  25                  30          


Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
        35                  40                  45              


Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
65                  70                  75                  80  


Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu 
                85                  90                  95      


Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
    130                 135                 140                 


Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr 
145                 150                 155                 160 


Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met Gly 
                165                 170                 175     


Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys 
            180                 185                 190         


Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
        195                 200                 205             


Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly 
225                 230                 235                 240 


Ala Gly Thr Thr Val Thr Val Glu Pro Lys Ser Cys Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Met Ala Arg Phe Ser Ser Ser Ser Leu Asp Leu Asn Trp 
            260                 265                 270         


Tyr Ser Leu Gly Leu Gln Xaa Lys Leu Ser Cys Lys Ala Ser Gly Tyr 
        275                 280                 285             


Thr Phe Thr Tyr Phe Asp Ile Asn Trp Leu Arg Gln Arg Pro Glu Gln 
    290                 295                 300                 


Gly Leu Glu Trp Ile Gly Val Ile Ser Pro Gly Asp Gly Asn Thr Asn 
305                 310                 315                 320 


Tyr Asn Glu Asn Phe Lys Gly Lys Ala Thr Leu Thr Ile Asp Lys Ser 
                325                 330                 335     


Ser Thr Thr Ala Tyr Ile Gln Leu Ser Arg Leu Thr Ser Glu Asp Ser 
            340                 345                 350         


Ala Val Tyr Phe Cys Ala Arg Asp Gly Asn Phe Pro Tyr Tyr Ala Met 
        355                 360                 365             


Asp Ser Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr 
    370                 375                 380                 


Thr Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Asp Ile 
385                 390                 395                 400 


Val Met Thr Gln Ile Pro Leu Ser Leu Pro Val Ile Leu Gly Asp Gln 
                405                 410                 415     


Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser Asn Gly 
            420                 425                 430         


Asn Thr Tyr Leu His Trp Phe Leu Gln Lys Pro Gly Gln Ser Pro Lys 
        435                 440                 445             


Leu Leu Ile Tyr Asn Val Ser Asn Leu Phe Ser Gly Val Pro Asp Arg 
    450                 455                 460                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg 
465                 470                 475                 480 


Val Glu Ala Glu Asp Leu Gly Ile Tyr Phe Cys Ser Gln Ser Thr His 
                485                 490                 495     


Val Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp 
            500                 505                 510         


Ala Ala Ala Ala Gly Ser 
        515             


<210>  39
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  39

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Ser Tyr Phe Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ile Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg His Asp Gly Ala Val Ala Gly Leu Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Tyr Val Leu Thr Gln Pro 
    130                 135                 140                 


Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Thr Cys Gly 
145                 150                 155                 160 


Gly Asn Asn Ile Gly Ser Lys Ser Val His Trp Tyr Gln Gln Pro Pro 
                165                 170                 175     


Gly Gln Ala Pro Val Val Val Val Tyr Asp Asp Ser Asp Arg Pro Ser 
            180                 185                 190         


Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr 
        195                 200                 205             


Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Val Trp Asp Ser Ser Ser Asp His Val Val Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Thr Val Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                245                 250                 255     


Pro Met Ala Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala 
            260                 265                 270         


Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile 
        275                 280                 285             


Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys 
    290                 295                 300                 


Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys 
305                 310                 315                 320 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn 
                325                 330                 335     


Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr 
            340                 345                 350         


Leu Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala 
        355                 360                 365             


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
    370                 375                 380                 


Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
385                 390                 395                 400 


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
                405                 410                 415     


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met 
            420                 425                 430         


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe 
        435                 440                 445             


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
    450                 455                 460                 


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
465                 470                 475                 480 


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
                485                 490                 495     


Gly Ala Gly Thr Thr Val Thr Val 
            500                 


<210>  40
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  40

Met Ala Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg 
            20                  25                  30          


Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
        35                  40                  45              


Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
65                  70                  75                  80  


Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu 
                85                  90                  95      


Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
    130                 135                 140                 


Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr 
145                 150                 155                 160 


Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met Gly 
                165                 170                 175     


Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys 
            180                 185                 190         


Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
        195                 200                 205             


Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly 
225                 230                 235                 240 


Ala Gly Thr Thr Val Thr Val Glu Pro Lys Ser Cys Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            260                 265                 270         


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile 
        275                 280                 285             


Ser Ser Gly Ser Tyr Phe Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys 
    290                 295                 300                 


Gly Leu Glu Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ile Thr Tyr Tyr 
305                 310                 315                 320 


Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys 
                325                 330                 335     


Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala 
            340                 345                 350         


Val Tyr Tyr Cys Ala Arg His Asp Gly Ala Val Ala Gly Leu Phe Asp 
        355                 360                 365             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Tyr Val Leu 
385                 390                 395                 400 


Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile 
                405                 410                 415     


Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His Trp Tyr Gln 
            420                 425                 430         


Gln Pro Pro Gly Gln Ala Pro Val Val Val Val Tyr Asp Asp Ser Asp 
        435                 440                 445             


Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn 
    450                 455                 460                 


Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Val 
465                 470                 475                 480 


Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His Val Val Phe Gly 
                485                 490                 495     


Gly Gly Thr Lys Leu Thr Val Leu 
            500                 


<210>  41
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  41

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Gln Val Ser Cys Arg Ala Ser Gly Tyr Ser Ile Asn Thr Tyr 
            20                  25                  30          


Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Ser Gly Val Thr Ser Tyr Ala Gln Lys Phe Gln 
    50                  55                  60                  


Gly Arg Val Thr Leu Thr Asn Asp Thr Ser Thr Asn Thr Val Tyr Met 
65                  70                  75                  80  


Gln Leu Asn Ser Leu Thr Ser Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp Ala Leu Trp Gly Asp Phe Gly Met Asp Val Trp Gly Lys Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr 
    130                 135                 140                 


Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu Ala Ser Gly Ala 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Met Ala Asp 
                245                 250                 255     


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
            260                 265                 270         


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu 
        275                 280                 285             


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
    290                 295                 300                 


Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe Ser Gly Ser 
305                 310                 315                 320 


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
                325                 330                 335     


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr 
            340                 345                 350         


Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Gly Gly Gly Ser 
        355                 360                 365             


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu 
    370                 375                 380                 


Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Met Lys Ile 
385                 390                 395                 400 


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp 
                405                 410                 415     


Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met Gly Leu Ile Asn 
            420                 425                 430         


Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Lys Ala 
        435                 440                 445             


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Leu 
    450                 455                 460                 


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Gly 
465                 470                 475                 480 


Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr 
                485                 490                 495     


Thr Val Thr Val 
            500 


<210>  42
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  42

Met Ala Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg 
            20                  25                  30          


Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
        35                  40                  45              


Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
65                  70                  75                  80  


Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu 
                85                  90                  95      


Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
    130                 135                 140                 


Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr 
145                 150                 155                 160 


Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met Gly 
                165                 170                 175     


Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys 
            180                 185                 190         


Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
        195                 200                 205             


Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly 
225                 230                 235                 240 


Ala Gly Thr Thr Val Thr Val Glu Pro Lys Ser Cys Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg 
            260                 265                 270         


Pro Gly Ala Ser Val Gln Val Ser Cys Arg Ala Ser Gly Tyr Ser Ile 
        275                 280                 285             


Asn Thr Tyr Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Ala Gly Leu 
    290                 295                 300                 


Glu Trp Met Gly Val Ile Asn Pro Ser Gly Val Thr Ser Tyr Ala Gln 
305                 310                 315                 320 


Lys Phe Gln Gly Arg Val Thr Leu Thr Asn Asp Thr Ser Thr Asn Thr 
                325                 330                 335     


Val Tyr Met Gln Leu Asn Ser Leu Thr Ser Ala Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Ala Arg Trp Ala Leu Trp Gly Asp Phe Gly Met Asp Val Trp 
        355                 360                 365             


Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
385                 390                 395                 400 


Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr Cys 
                405                 410                 415     


Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln Gln Lys 
            420                 425                 430         


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu Ala 
        435                 440                 445             


Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    450                 455                 460                 


Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr 
465                 470                 475                 480 


Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
                485                 490                 495     


Leu Glu Ile Lys 
            500 


<210>  43
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  43

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Leu His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Tyr 
        35                  40                  45              


Ala Ala Ile Ser Tyr Asp Gly Ser Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Ser Pro Glu Asp Thr Ala Leu Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Trp Phe Val Glu Pro Leu Ser Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly 
    130                 135                 140                 


Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn 
145                 150                 155                 160 


Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile 
        195                 200                 205             


Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp 
    210                 215                 220                 


Asp Asp Ser Leu Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr 
225                 230                 235                 240 


Val Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Met Ala 
                245                 250                 255     


Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
            260                 265                 270         


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
        275                 280                 285             


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
    290                 295                 300                 


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe Ser Gly 
305                 310                 315                 320 


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
                325                 330                 335     


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp 
            340                 345                 350         


Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
    370                 375                 380                 


Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Met Lys 
385                 390                 395                 400 


Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn 
                405                 410                 415     


Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met Gly Leu Ile 
            420                 425                 430         


Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Lys 
        435                 440                 445             


Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu 
    450                 455                 460                 


Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser 
465                 470                 475                 480 


Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Ala Gly 
                485                 490                 495     


Thr Thr Val Thr Val 
            500     


<210>  44
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  44

Met Ala Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg 
            20                  25                  30          


Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
        35                  40                  45              


Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
65                  70                  75                  80  


Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu 
                85                  90                  95      


Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
    130                 135                 140                 


Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr 
145                 150                 155                 160 


Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met Gly 
                165                 170                 175     


Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys 
            180                 185                 190         


Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
        195                 200                 205             


Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly 
225                 230                 235                 240 


Ala Gly Thr Thr Val Thr Val Glu Pro Lys Ser Cys Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln 
            260                 265                 270         


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        275                 280                 285             


Ser Ser Tyr Gly Leu His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    290                 295                 300                 


Glu Trp Tyr Ala Ala Ile Ser Tyr Asp Gly Ser Lys Lys Tyr Tyr Ala 
305                 310                 315                 320 


Asp Ser Val Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                325                 330                 335     


Thr Leu Tyr Leu Gln Met Asn Ser Leu Ser Pro Glu Asp Thr Ala Leu 
            340                 345                 350         


Tyr Phe Cys Ala Arg Gly Trp Phe Val Glu Pro Leu Ser Trp Gly Gln 
        355                 360                 365             


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser 
385                 390                 395                 400 


Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser 
                405                 410                 415     


Ser Ser Asn Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln Gln Leu Pro 
            420                 425                 430         


Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser 
        435                 440                 445             


Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser 
    450                 455                 460                 


Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
465                 470                 475                 480 


Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val Phe Gly Thr Gly Thr 
                485                 490                 495     


Lys Leu Thr Val Leu 
            500     


<210>  45
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  45

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Phe Leu His Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Ile Glu Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly Glu 
    130                 135                 140                 


Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser Asn 
145                 150                 155                 160 


Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
                165                 170                 175     


Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro Asp 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
        195                 200                 205             


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala Leu 
    210                 215                 220                 


Gln Thr Phe Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Glu Pro Lys 
225                 230                 235                 240 


Ser Cys Asp Lys Thr His Thr Cys Pro Met Ala Asp Ile Gln Met Thr 
                245                 250                 255     


Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile 
            260                 265                 270         


Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln 
        275                 280                 285             


Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg 
    290                 295                 300                 


Leu His Ser Gly Val Pro Ser Lys Phe Ser Gly Ser Gly Ser Gly Thr 
305                 310                 315                 320 


Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr 
                325                 330                 335     


Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Ala Gly Gly 
            340                 345                 350         


Thr Lys Leu Glu Ile Lys Arg Ala Gly Gly Gly Ser Gly Gly Gly Ser 
        355                 360                 365             


Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly 
    370                 375                 380                 


Pro Glu Leu Val Lys Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala 
385                 390                 395                 400 


Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser 
                405                 410                 415     


His Gly Lys Asn Leu Glu Trp Met Gly Leu Ile Asn Pro Tyr Lys Gly 
            420                 425                 430         


Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser 
    450                 455                 460                 


Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp 
465                 470                 475                 480 


Ser Asp Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val 
                485                 490                 495     


<210>  46
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  46

Met Ala Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg 
            20                  25                  30          


Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
        35                  40                  45              


Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
65                  70                  75                  80  


Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu 
                85                  90                  95      


Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
    130                 135                 140                 


Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr 
145                 150                 155                 160 


Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met Gly 
                165                 170                 175     


Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys 
            180                 185                 190         


Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
        195                 200                 205             


Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly 
225                 230                 235                 240 


Ala Gly Thr Thr Val Thr Val Glu Pro Lys Ser Cys Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            260                 265                 270         


Pro Gly Ser Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe 
        275                 280                 285             


Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    290                 295                 300                 


Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala 
305                 310                 315                 320 


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser 
                325                 330                 335     


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Tyr Cys Ala Arg Asp Pro Phe Leu His Tyr Trp Gly Gln Gly Thr 
        355                 360                 365             


Leu Val Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Glu Ile Glu Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr 
385                 390                 395                 400 


Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu 
                405                 410                 415     


His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly 
            420                 425                 430         


Gln Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly 
        435                 440                 445             


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    450                 455                 460                 


Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met 
465                 470                 475                 480 


Gln Ala Leu Gln Thr Phe Thr Phe Gly Pro Gly Thr Lys Val Glu Ile 
                485                 490                 495     


<210>  47
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  47

Gln Val Gln Leu Val Glu Ser Gly Pro Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Ala Val Ser Gly Phe Ser Val Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Gly Gly Ile Thr Asn Tyr Asn Ser Ala Phe Met 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Ser Arg Gly Gly His Tyr Gly Tyr Ala Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Thr Pro Ala Thr 
    130                 135                 140                 


Leu Ser Val Ser Ala Gly Glu Arg Val Thr Ile Thr Cys Lys Ala Ser 
145                 150                 155                 160 


Gln Ser Val Ser Asn Asp Val Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
                165                 170                 175     


Ala Pro Arg Leu Leu Ile Tyr Ser Ala Ser Asn Arg Tyr Ser Gly Val 
            180                 185                 190         


Pro Ala Arg Phe Ser Gly Ser Gly Tyr Gly Thr Glu Phe Thr Phe Thr 
        195                 200                 205             


Ile Ser Ser Val Gln Ser Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln 
    210                 215                 220                 


Asp Tyr Ser Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Met Ala Asp Ile Gln 
                245                 250                 255     


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
            260                 265                 270         


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp 
        275                 280                 285             


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr 
    290                 295                 300                 


Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe Ser Gly Ser Gly Ser 
305                 310                 315                 320 


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
                325                 330                 335     


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Ala 
            340                 345                 350         


Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Gly Gly Gly Ser Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Gln Gln 
    370                 375                 380                 


Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Met Lys Ile Ser Cys 
385                 390                 395                 400 


Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys 
                405                 410                 415     


Gln Ser His Gly Lys Asn Leu Glu Trp Met Gly Leu Ile Asn Pro Tyr 
            420                 425                 430         


Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu 
        435                 440                 445             


Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu 
    450                 455                 460                 


Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr 
465                 470                 475                 480 


Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val 
                485                 490                 495     


Thr Val 
        


<210>  48
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  48

Met Ala Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg 
            20                  25                  30          


Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
        35                  40                  45              


Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
65                  70                  75                  80  


Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu 
                85                  90                  95      


Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
    130                 135                 140                 


Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr 
145                 150                 155                 160 


Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met Gly 
                165                 170                 175     


Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys 
            180                 185                 190         


Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
        195                 200                 205             


Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly 
225                 230                 235                 240 


Ala Gly Thr Thr Val Thr Val Glu Pro Lys Ser Cys Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Gln Val Gln Leu Val Glu Ser Gly Pro Gly Val Val Gln 
            260                 265                 270         


Pro Gly Arg Ser Leu Arg Ile Ser Cys Ala Val Ser Gly Phe Ser Val 
        275                 280                 285             


Thr Asn Tyr Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
    290                 295                 300                 


Glu Trp Leu Gly Val Ile Trp Ala Gly Gly Ile Thr Asn Tyr Asn Ser 
305                 310                 315                 320 


Ala Phe Met Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr 
                325                 330                 335     


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr 
            340                 345                 350         


Tyr Cys Ala Ser Arg Gly Gly His Tyr Gly Tyr Ala Leu Asp Tyr Trp 
        355                 360                 365             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Thr 
385                 390                 395                 400 


Pro Ala Thr Leu Ser Val Ser Ala Gly Glu Arg Val Thr Ile Thr Cys 
                405                 410                 415     


Lys Ala Ser Gln Ser Val Ser Asn Asp Val Thr Trp Tyr Gln Gln Lys 
            420                 425                 430         


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Ser Ala Ser Asn Arg Tyr 
        435                 440                 445             


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Tyr Gly Thr Glu Phe 
    450                 455                 460                 


Thr Phe Thr Ile Ser Ser Val Gln Ser Glu Asp Phe Ala Val Tyr Phe 
465                 470                 475                 480 


Cys Gln Gln Asp Tyr Ser Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile 
                485                 490                 495     


Lys Arg 
        


<210>  49
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  49

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly 
            20          


<210>  50
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  50

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu 
    130                 135                 140                 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
145                 150                 155                 160 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys 
                165                 170                 175     


Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
            180                 185                 190         


Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp 
        195                 200                 205             


Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr 
    210                 215                 220                 


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Val Trp 
                245                 250                 255     


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Met Ala Asp Ile Gln Met Thr Gln Thr Thr 
        275                 280                 285             


Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg 
    290                 295                 300                 


Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
305                 310                 315                 320 


Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 
                325                 330                 335     


Gly Val Pro Ser Lys Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
            340                 345                 350         


Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys 
        355                 360                 365             


Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu 
    370                 375                 380                 


Glu Ile Lys Arg Ala Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
                405                 410                 415     


Val Lys Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
            420                 425                 430         


Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys 
        435                 440                 445             


Asn Leu Glu Trp Met Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr 
    450                 455                 460                 


Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser 
465                 470                 475                 480 


Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser 
                485                 490                 495     


Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp 
            500                 505                 510         


Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val 
        515                 520                 525 


<210>  51
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  51

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Met Ala Asp Ile Gln Met Thr Gln Thr Thr 
            20                  25                  30          


Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg 
        35                  40                  45              


Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 
65                  70                  75                  80  


Gly Val Pro Ser Lys Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
                85                  90                  95      


Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys 
            100                 105                 110         


Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
145                 150                 155                 160 


Val Lys Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys 
            180                 185                 190         


Asn Leu Glu Trp Met Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr 
        195                 200                 205             


Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser 
    210                 215                 220                 


Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp 
                245                 250                 255     


Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Glu Pro Lys 
            260                 265                 270         


Ser Cys Asp Lys Thr His Thr Cys Pro Asp Ile Gln Met Thr Gln Ser 
        275                 280                 285             


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
    290                 295                 300                 


Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys 
305                 310                 315                 320 


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr 
                325                 330                 335     


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe 
            340                 345                 350         


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
        355                 360                 365             


Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys 
    370                 375                 380                 


Val Glu Ile Lys Arg Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
385                 390                 395                 400 


Ser Gly Glu Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
                405                 410                 415     


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
            420                 425                 430         


Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys 
        435                 440                 445             


Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg 
    450                 455                 460                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser 
465                 470                 475                 480 


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
                485                 490                 495     


Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met 
            500                 505                 510         


Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        515                 520                 525 


<210>  52
<211>  537
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  52

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Met Ala Asp Ile Gln Met Thr Gln Thr Thr 
            20                  25                  30          


Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg 
        35                  40                  45              


Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 
65                  70                  75                  80  


Gly Val Pro Ser Lys Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
                85                  90                  95      


Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys 
            100                 105                 110         


Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
145                 150                 155                 160 


Val Lys Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys 
            180                 185                 190         


Asn Leu Glu Trp Met Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr 
        195                 200                 205             


Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser 
    210                 215                 220                 


Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp 
                245                 250                 255     


Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Glu Pro Lys 
            260                 265                 270         


Ser Cys Asp Lys Thr His Thr Cys Pro Gln Ile Gln Leu Val Gln Ser 
        275                 280                 285             


Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys 
    290                 295                 300                 


Ala Ser Gly Tyr Thr Phe Thr Glu Tyr Pro Ile His Trp Val Lys Gln 
305                 310                 315                 320 


Ala Pro Gly Lys Gly Phe Lys Trp Met Gly Met Ile Tyr Thr Asp Ile 
                325                 330                 335     


Gly Lys Pro Thr Tyr Ala Glu Glu Phe Gly Arg Phe Ala Phe Ser Leu 
            340                 345                 350         


Glu Thr Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn 
        355                 360                 365             


Glu Asp Thr Ala Thr Tyr Phe Cys Val Arg Asp Arg Tyr Asp Ser Leu 
    370                 375                 380                 


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val 
                405                 410                 415     


Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala 
            420                 425                 430         


Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn 
        435                 440                 445             


Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu 
    450                 455                 460                 


Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe 
465                 470                 475                 480 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val 
                485                 490                 495     


Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His Val 
            500                 505                 510         


Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu Pro Lys 
        515                 520                 525             


Ser Cys Asp Lys Thr His Thr Cys Pro 
    530                 535         


<210>  53
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  53

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Gln Leu Val Gln Ser Gly Pro Glu 
            20                  25                  30          


Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Glu Tyr Pro Ile His Trp Val Lys Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Phe Lys Trp Met Gly Met Ile Tyr Thr Asp Ile Gly Lys Pro 
65                  70                  75                  80  


Thr Tyr Ala Glu Glu Phe Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser 
                85                  90                  95      


Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr 
            100                 105                 110         


Ala Thr Tyr Phe Cys Val Arg Asp Arg Tyr Asp Ser Leu Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln 
145                 150                 155                 160 


Thr Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser 
                165                 170                 175     


Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu 
            180                 185                 190         


His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
        195                 200                 205             


Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu 
225                 230                 235                 240 


Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro Trp Thr 
                245                 250                 255     


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu Pro Lys Ser Cys Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Met Ala Asp Ile Gln Met Thr Gln Thr Thr 
        275                 280                 285             


Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg 
    290                 295                 300                 


Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
305                 310                 315                 320 


Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 
                325                 330                 335     


Gly Val Pro Ser Lys Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
            340                 345                 350         


Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys 
        355                 360                 365             


Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu 
    370                 375                 380                 


Glu Ile Lys Arg Ala Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
                405                 410                 415     


Val Lys Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
            420                 425                 430         


Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys 
        435                 440                 445             


Asn Leu Glu Trp Met Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr 
    450                 455                 460                 


Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser 
465                 470                 475                 480 


Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser 
                485                 490                 495     


Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp 
            500                 505                 510         


Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val 
        515                 520                 525 


<210>  54
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  54

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Glu Val Gln Leu Val Glu Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Asp Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly 
        35                  40                  45              


Tyr Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Glu Thr 
65                  70                  75                  80  


Thr Tyr Ser Pro Ala Phe Gln Gly Asp Val Thr Ile Ser Val Asp Lys 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp 
            100                 105                 110         


Thr Gly Ile Tyr Tyr Cys Ala Arg Arg Arg Gly Asn Tyr Tyr Met Asp 
        115                 120                 125             


Val Trp Gly Asn Gly Thr Leu Val Thr Val Ser Ser Leu Lys Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Ser 
145                 150                 155                 160 


Thr Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly 
                165                 170                 175     


Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly 
            180                 185                 190         


Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys 
        195                 200                 205             


Leu Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg 
    210                 215                 220                 


Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly 
225                 230                 235                 240 


Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser 
                245                 250                 255     


Ser Ser Thr Arg His Val Phe Gly Thr Gly Thr Gln Leu Thr Val Leu 
            260                 265                 270         


Gly Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Met Ala Asp 
        275                 280                 285             


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
    290                 295                 300                 


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu 
305                 310                 315                 320 


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
                325                 330                 335     


Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe Ser Gly Ser 
            340                 345                 350         


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
        355                 360                 365             


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr 
    370                 375                 380                 


Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu 
                405                 410                 415     


Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Met Lys Ile 
            420                 425                 430         


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp 
        435                 440                 445             


Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met Gly Leu Ile Asn 
    450                 455                 460                 


Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Lys Ala 
465                 470                 475                 480 


Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Leu 
                485                 490                 495     


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Gly 
            500                 505                 510         


Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr 
        515                 520                 525             


Thr Val Thr Val 
    530         


<210>  55
<211>  537
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  55

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Met Ala Asp Ile Gln Met Thr Gln Thr Thr 
            20                  25                  30          


Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg 
        35                  40                  45              


Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 
65                  70                  75                  80  


Gly Val Pro Ser Lys Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
                85                  90                  95      


Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys 
            100                 105                 110         


Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
145                 150                 155                 160 


Val Lys Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys 
            180                 185                 190         


Asn Leu Glu Trp Met Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr 
        195                 200                 205             


Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser 
    210                 215                 220                 


Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp 
                245                 250                 255     


Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Glu Pro Lys 
            260                 265                 270         


Ser Cys Asp Lys Thr His Thr Cys Pro Gln Ile Gln Leu Val Gln Ser 
        275                 280                 285             


Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys 
    290                 295                 300                 


Ala Ser Gly Tyr Thr Phe Thr Glu Tyr Pro Ile His Trp Val Lys Gln 
305                 310                 315                 320 


Ala Pro Gly Lys Gly Phe Lys Trp Met Gly Met Ile Tyr Thr Asp Ile 
                325                 330                 335     


Gly Lys Pro Thr Tyr Ala Glu Glu Phe Gly Arg Phe Ala Phe Ser Leu 
            340                 345                 350         


Glu Thr Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn 
        355                 360                 365             


Glu Asp Thr Ala Thr Tyr Phe Cys Val Arg Asp Arg Tyr Asp Ser Leu 
    370                 375                 380                 


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val 
                405                 410                 415     


Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala 
            420                 425                 430         


Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn 
        435                 440                 445             


Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu 
    450                 455                 460                 


Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe 
465                 470                 475                 480 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val 
                485                 490                 495     


Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His Val 
            500                 505                 510         


Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu Pro Lys 
        515                 520                 525             


Ser Cys Asp Lys Thr His Thr Cys Pro 
    530                 535         


<210>  56
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  56

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Val Gln Leu Gln Gln Pro Gly Ala Glu 
            20                  25                  30          


Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly 
    50                  55                  60                  


Arg Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr 
65                  70                  75                  80  


Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys 
                85                  90                  95      


Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp 
            100                 105                 110         


Ser Ala Val Tyr Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp 
        115                 120                 125             


Tyr Phe Asn Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ala Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile 
145                 150                 155                 160 


Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys 
                165                 170                 175     


Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala 
225                 230                 235                 240 


Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly 
                245                 250                 255     


Gly Gly Thr Lys Leu Glu Ile Lys Glu Pro Lys Ser Cys Asp Lys Thr 
            260                 265                 270         


His Thr Cys Pro Met Ala Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
        275                 280                 285             


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
    290                 295                 300                 


Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
305                 310                 315                 320 


Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val 
                325                 330                 335     


Pro Ser Lys Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
            340                 345                 350         


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
        355                 360                 365             


Gly Asn Thr Leu Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile 
    370                 375                 380                 


Lys Arg Ala Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
                405                 410                 415     


Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
            420                 425                 430         


Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu 
        435                 440                 445             


Glu Trp Met Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn 
    450                 455                 460                 


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
465                 470                 475                 480 


Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val 
                485                 490                 495     


Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe 
            500                 505                 510         


Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val 
        515                 520             


<210>  57
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  57

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Met Ala Asp Ile Gln Met Thr Gln Thr Thr 
            20                  25                  30          


Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg 
        35                  40                  45              


Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 
65                  70                  75                  80  


Gly Val Pro Ser Lys Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
                85                  90                  95      


Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys 
            100                 105                 110         


Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
145                 150                 155                 160 


Val Lys Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys 
            180                 185                 190         


Asn Leu Glu Trp Met Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr 
        195                 200                 205             


Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser 
    210                 215                 220                 


Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp 
                245                 250                 255     


Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Glu Pro Lys 
            260                 265                 270         


Ser Cys Asp Lys Thr His Thr Cys Pro Gln Val Gln Leu Gln Gln Pro 
        275                 280                 285             


Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
    290                 295                 300                 


Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln 
305                 310                 315                 320 


Thr Pro Gly Arg Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn 
                325                 330                 335     


Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr 
            340                 345                 350         


Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr 
        355                 360                 365             


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly 
    370                 375                 380                 


Gly Asp Trp Tyr Phe Asn Val Trp Gly Ala Gly Thr Thr Val Thr Val 
385                 390                 395                 400 


Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                405                 410                 415     


Ser Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro 
            420                 425                 430         


Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr 
        435                 440                 445             


Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile 
    450                 455                 460                 


Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly 
465                 470                 475                 480 


Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala 
                485                 490                 495     


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro 
            500                 505                 510         


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        515                 520             


<210>  58
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  58

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Glu Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr 
65                  70                  75                  80  


Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys 
                85                  90                  95      


Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp 
            100                 105                 110         


Ser Ala Asp Tyr Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr 
        115                 120                 125             


Trp Phe Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu 
                165                 170                 175     


Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Asn Tyr Met Asp 
            180                 185                 190         


Trp Tyr Gln Lys Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala 
        195                 200                 205             


Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp 
225                 230                 235                 240 


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu Pro Lys Ser Cys Asp Lys 
            260                 265                 270         


Thr His Thr Cys Pro Met Ala Asp Ile Gln Met Thr Gln Thr Thr Ser 
        275                 280                 285             


Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala 
    290                 295                 300                 


Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp 
305                 310                 315                 320 


Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly 
                325                 330                 335     


Val Pro Ser Lys Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu 
            340                 345                 350         


Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln 
        355                 360                 365             


Gln Gly Asn Thr Leu Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu 
    370                 375                 380                 


Ile Lys Arg Ala Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
                405                 410                 415     


Lys Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser 
            420                 425                 430         


Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn 
        435                 440                 445             


Leu Glu Trp Met Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr 
    450                 455                 460                 


Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
465                 470                 475                 480 


Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala 
                485                 490                 495     


Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr 
            500                 505                 510         


Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val 
        515                 520                 


<210>  59
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  59

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Met Ala Asp Ile Gln Met Thr Gln Thr Thr 
            20                  25                  30          


Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg 
        35                  40                  45              


Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 
65                  70                  75                  80  


Gly Val Pro Ser Lys Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
                85                  90                  95      


Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys 
            100                 105                 110         


Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
145                 150                 155                 160 


Val Lys Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys 
            180                 185                 190         


Asn Leu Glu Trp Met Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr 
        195                 200                 205             


Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser 
    210                 215                 220                 


Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp 
                245                 250                 255     


Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Glu Pro Lys 
            260                 265                 270         


Ser Cys Asp Lys Thr His Thr Cys Pro Glu Val Gln Leu Gln Gln Ser 
        275                 280                 285             


Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
    290                 295                 300                 


Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln 
305                 310                 315                 320 


Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn 
                325                 330                 335     


Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr 
            340                 345                 350         


Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr 
        355                 360                 365             


Ser Glu Asp Ser Ala Asp Tyr Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly 
    370                 375                 380                 


Ser Ser Tyr Trp Phe Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr 
385                 390                 395                 400 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                405                 410                 415     


Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser 
            420                 425                 430         


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Asn 
        435                 440                 445             


Tyr Met Asp Trp Tyr Gln Lys Lys Pro Gly Ser Ser Pro Lys Pro Trp 
    450                 455                 460                 


Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
465                 470                 475                 480 


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
                485                 490                 495     


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro 
            500                 505                 510         


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        515                 520                 


<210>  60
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  Xaa can be any naturally occurring amino acid

<400>  60

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Met Ala Arg Phe Ser Ser Ser Ser Leu Asp 
            20                  25                  30          


Leu Asn Trp Tyr Ser Leu Gly Leu Gln Xaa Lys Leu Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Thr Phe Thr Tyr Phe Asp Ile Asn Trp Leu Arg Gln Arg 
    50                  55                  60                  


Pro Glu Gln Gly Leu Glu Trp Ile Gly Val Ile Ser Pro Gly Asp Gly 
65                  70                  75                  80  


Asn Thr Asn Tyr Asn Glu Asn Phe Lys Gly Lys Ala Thr Leu Thr Ile 
                85                  90                  95      


Asp Lys Ser Ser Thr Thr Ala Tyr Ile Gln Leu Ser Arg Leu Thr Ser 
            100                 105                 110         


Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Asp Gly Asn Phe Pro Tyr 
        115                 120                 125             


Tyr Ala Met Asp Ser Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Lys Thr Thr Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg 
145                 150                 155                 160 


Val Asp Ile Val Met Thr Gln Ile Pro Leu Ser Leu Pro Val Ile Leu 
                165                 170                 175     


Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr 
            180                 185                 190         


Ser Asn Gly Asn Thr Tyr Leu His Trp Phe Leu Gln Lys Pro Gly Gln 
        195                 200                 205             


Ser Pro Lys Leu Leu Ile Tyr Asn Val Ser Asn Leu Phe Ser Gly Val 
    210                 215                 220                 


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
225                 230                 235                 240 


Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Phe Cys Ser Gln 
                245                 250                 255     


Ser Thr His Val Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            260                 265                 270         


Arg Ala Asp Ala Ala Ala Ala Gly Ser Glu Pro Lys Ser Cys Asp Lys 
        275                 280                 285             


Thr His Thr Cys Pro Met Ala Asp Ile Gln Met Thr Gln Thr Thr Ser 
    290                 295                 300                 


Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala 
305                 310                 315                 320 


Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp 
                325                 330                 335     


Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly 
            340                 345                 350         


Val Pro Ser Lys Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu 
        355                 360                 365             


Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln 
    370                 375                 380                 


Gln Gly Asn Thr Leu Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu 
385                 390                 395                 400 


Ile Lys Arg Ala Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
                405                 410                 415     


Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            420                 425                 430         


Lys Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser 
        435                 440                 445             


Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn 
    450                 455                 460                 


Leu Glu Trp Met Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr 
465                 470                 475                 480 


Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                485                 490                 495     


Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala 
            500                 505                 510         


Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr 
        515                 520                 525             


Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val 
    530                 535                 540 


<210>  61
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<222>  (301)..(301)
<223>  Xaa can be any naturally occurring amino acid

<400>  61

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Met Ala Asp Ile Gln Met Thr Gln Thr Thr 
            20                  25                  30          


Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg 
        35                  40                  45              


Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 
65                  70                  75                  80  


Gly Val Pro Ser Lys Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
                85                  90                  95      


Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys 
            100                 105                 110         


Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
145                 150                 155                 160 


Val Lys Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys 
            180                 185                 190         


Asn Leu Glu Trp Met Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr 
        195                 200                 205             


Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser 
    210                 215                 220                 


Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp 
                245                 250                 255     


Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Glu Pro Lys 
            260                 265                 270         


Ser Cys Asp Lys Thr His Thr Cys Pro Met Ala Arg Phe Ser Ser Ser 
        275                 280                 285             


Ser Leu Asp Leu Asn Trp Tyr Ser Leu Gly Leu Gln Xaa Lys Leu Ser 
    290                 295                 300                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Tyr Phe Asp Ile Asn Trp Leu 
305                 310                 315                 320 


Arg Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Val Ile Ser Pro 
                325                 330                 335     


Gly Asp Gly Asn Thr Asn Tyr Asn Glu Asn Phe Lys Gly Lys Ala Thr 
            340                 345                 350         


Leu Thr Ile Asp Lys Ser Ser Thr Thr Ala Tyr Ile Gln Leu Ser Arg 
        355                 360                 365             


Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Asp Gly Asn 
    370                 375                 380                 


Phe Pro Tyr Tyr Ala Met Asp Ser Trp Gly Gln Gly Thr Ser Val Thr 
385                 390                 395                 400 


Val Ser Ser Ala Lys Thr Thr Pro Lys Leu Glu Glu Gly Glu Phe Ser 
                405                 410                 415     


Glu Ala Arg Val Asp Ile Val Met Thr Gln Ile Pro Leu Ser Leu Pro 
            420                 425                 430         


Val Ile Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        435                 440                 445             


Leu Val Tyr Ser Asn Gly Asn Thr Tyr Leu His Trp Phe Leu Gln Lys 
    450                 455                 460                 


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Asn Val Ser Asn Leu Phe 
465                 470                 475                 480 


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                485                 490                 495     


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Phe 
            500                 505                 510         


Cys Ser Gln Ser Thr His Val Pro Thr Phe Gly Gly Gly Thr Lys Leu 
        515                 520                 525             


Glu Ile Lys Arg Ala Asp Ala Ala Ala Ala Gly Ser 
    530                 535                 540 


<210>  62
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  62

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Gly Ser Tyr Phe Trp Gly Trp Ile Arg Gln Pro 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ile 
65                  70                  75                  80  


Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp 
                85                  90                  95      


Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg His Asp Gly Ala Val Ala Gly 
        115                 120                 125             


Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
145                 150                 155                 160 


Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr 
                165                 170                 175     


Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His 
            180                 185                 190         


Trp Tyr Gln Gln Pro Pro Gly Gln Ala Pro Val Val Val Val Tyr Asp 
        195                 200                 205             


Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn 
    210                 215                 220                 


Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly Asp 
225                 230                 235                 240 


Glu Ala Val Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His Val 
                245                 250                 255     


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Glu Pro Lys Ser Cys 
            260                 265                 270         


Asp Lys Thr His Thr Cys Pro Met Ala Asp Ile Gln Met Thr Gln Thr 
        275                 280                 285             


Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys 
    290                 295                 300                 


Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys 
305                 310                 315                 320 


Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His 
                325                 330                 335     


Ser Gly Val Pro Ser Lys Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
            340                 345                 350         


Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe 
        355                 360                 365             


Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Ala Gly Gly Thr Lys 
    370                 375                 380                 


Leu Glu Ile Lys Arg Ala Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu 
                405                 410                 415     


Leu Val Lys Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly 
            420                 425                 430         


Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly 
        435                 440                 445             


Lys Asn Leu Glu Trp Met Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser 
    450                 455                 460                 


Thr Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys 
465                 470                 475                 480 


Ser Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp 
                485                 490                 495     


Ser Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp 
            500                 505                 510         


Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val 
        515                 520                 525     


<210>  63
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  63

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Met Ala Asp Ile Gln Met Thr Gln Thr Thr 
            20                  25                  30          


Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg 
        35                  40                  45              


Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 
65                  70                  75                  80  


Gly Val Pro Ser Lys Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
                85                  90                  95      


Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys 
            100                 105                 110         


Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
145                 150                 155                 160 


Val Lys Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys 
            180                 185                 190         


Asn Leu Glu Trp Met Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr 
        195                 200                 205             


Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser 
    210                 215                 220                 


Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp 
                245                 250                 255     


Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Glu Pro Lys 
            260                 265                 270         


Ser Cys Asp Lys Thr His Thr Cys Pro Gln Leu Gln Leu Gln Glu Ser 
        275                 280                 285             


Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr 
    290                 295                 300                 


Val Ser Gly Gly Ser Ile Ser Ser Gly Ser Tyr Phe Trp Gly Trp Ile 
305                 310                 315                 320 


Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr Tyr 
                325                 330                 335     


Ser Gly Ile Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile 
            340                 345                 350         


Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val 
        355                 360                 365             


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg His Asp Gly Ala 
    370                 375                 380                 


Val Ala Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                405                 410                 415     


Gly Ser Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro 
            420                 425                 430         


Gly Gln Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys 
        435                 440                 445             


Ser Val His Trp Tyr Gln Gln Pro Pro Gly Gln Ala Pro Val Val Val 
    450                 455                 460                 


Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser 
465                 470                 475                 480 


Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu 
                485                 490                 495     


Ala Gly Asp Glu Ala Val Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser 
            500                 505                 510         


Asp His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        515                 520                 525     


<210>  64
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  64

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Arg Pro Gly Ala Ser Val Gln Val Ser Cys Arg Ala Ser Gly 
        35                  40                  45              


Tyr Ser Ile Asn Thr Tyr Tyr Met Gln Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Ala Gly Leu Glu Trp Met Gly Val Ile Asn Pro Ser Gly Val Thr Ser 
65                  70                  75                  80  


Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Leu Thr Asn Asp Thr Ser 
                85                  90                  95      


Thr Asn Thr Val Tyr Met Gln Leu Asn Ser Leu Thr Ser Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Trp Ala Leu Trp Gly Asp Phe Gly Met 
        115                 120                 125             


Asp Val Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
145                 150                 155                 160 


Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg Val Thr 
                165                 170                 175     


Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser 
        195                 200                 205             


Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
225                 230                 235                 240 


Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly 
                245                 250                 255     


Gly Thr Lys Leu Glu Ile Lys Glu Pro Lys Ser Cys Asp Lys Thr His 
            260                 265                 270         


Thr Cys Pro Met Ala Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
        275                 280                 285             


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
    290                 295                 300                 


Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
305                 310                 315                 320 


Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro 
                325                 330                 335     


Ser Lys Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
            340                 345                 350         


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
        355                 360                 365             


Asn Thr Leu Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys 
    370                 375                 380                 


Arg Ala Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro 
                405                 410                 415     


Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr 
            420                 425                 430         


Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu 
        435                 440                 445             


Trp Met Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln 
    450                 455                 460                 


Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr 
465                 470                 475                 480 


Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
                485                 490                 495     


Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp 
            500                 505                 510         


Val Trp Gly Ala Gly Thr Thr Val Thr Val 
        515                 520         


<210>  65
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  65

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Met Ala Asp Ile Gln Met Thr Gln Thr Thr 
            20                  25                  30          


Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg 
        35                  40                  45              


Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 
65                  70                  75                  80  


Gly Val Pro Ser Lys Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
                85                  90                  95      


Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys 
            100                 105                 110         


Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
145                 150                 155                 160 


Val Lys Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys 
            180                 185                 190         


Asn Leu Glu Trp Met Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr 
        195                 200                 205             


Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser 
    210                 215                 220                 


Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp 
                245                 250                 255     


Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Glu Pro Lys 
            260                 265                 270         


Ser Cys Asp Lys Thr His Thr Cys Pro Gln Val Gln Leu Val Gln Ser 
        275                 280                 285             


Gly Ala Glu Val Lys Arg Pro Gly Ala Ser Val Gln Val Ser Cys Arg 
    290                 295                 300                 


Ala Ser Gly Tyr Ser Ile Asn Thr Tyr Tyr Met Gln Trp Val Arg Gln 
305                 310                 315                 320 


Ala Pro Gly Ala Gly Leu Glu Trp Met Gly Val Ile Asn Pro Ser Gly 
                325                 330                 335     


Val Thr Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Leu Thr Asn 
            340                 345                 350         


Asp Thr Ser Thr Asn Thr Val Tyr Met Gln Leu Asn Ser Leu Thr Ser 
        355                 360                 365             


Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Ala Leu Trp Gly Asp 
    370                 375                 380                 


Phe Gly Met Asp Val Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
                405                 410                 415     


Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp 
            420                 425                 430         


Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu 
        435                 440                 445             


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
    450                 455                 460                 


Lys Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser 
465                 470                 475                 480 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
                485                 490                 495     


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr 
            500                 505                 510         


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        515                 520         


<210>  66
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  66

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Val Gln Leu Val Gln Ser Gly Gly Gly 
            20                  25                  30          


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Gly Leu His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Tyr Ala Ala Ile Ser Tyr Asp Gly Ser Lys Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Ser Pro Glu Asp 
            100                 105                 110         


Thr Ala Leu Tyr Phe Cys Ala Arg Gly Trp Phe Val Glu Pro Leu Ser 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln 
145                 150                 155                 160 


Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys 
                165                 170                 175     


Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln 
            180                 185                 190         


Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln 
        195                 200                 205             


Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr 
    210                 215                 220                 


Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp 
225                 230                 235                 240 


Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val Phe Gly 
                245                 250                 255     


Thr Gly Thr Lys Leu Thr Val Leu Glu Pro Lys Ser Cys Asp Lys Thr 
            260                 265                 270         


His Thr Cys Pro Met Ala Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
        275                 280                 285             


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
    290                 295                 300                 


Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
305                 310                 315                 320 


Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val 
                325                 330                 335     


Pro Ser Lys Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
            340                 345                 350         


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
        355                 360                 365             


Gly Asn Thr Leu Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile 
    370                 375                 380                 


Lys Arg Ala Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
                405                 410                 415     


Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
            420                 425                 430         


Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu 
        435                 440                 445             


Glu Trp Met Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn 
    450                 455                 460                 


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
465                 470                 475                 480 


Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val 
                485                 490                 495     


Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe 
            500                 505                 510         


Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val 
        515                 520             


<210>  67
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  67

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Met Ala Asp Ile Gln Met Thr Gln Thr Thr 
            20                  25                  30          


Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg 
        35                  40                  45              


Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 
65                  70                  75                  80  


Gly Val Pro Ser Lys Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
                85                  90                  95      


Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys 
            100                 105                 110         


Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
145                 150                 155                 160 


Val Lys Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys 
            180                 185                 190         


Asn Leu Glu Trp Met Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr 
        195                 200                 205             


Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser 
    210                 215                 220                 


Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp 
                245                 250                 255     


Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Glu Pro Lys 
            260                 265                 270         


Ser Cys Asp Lys Thr His Thr Cys Pro Gln Val Gln Leu Val Gln Ser 
        275                 280                 285             


Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala 
    290                 295                 300                 


Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly Leu His Trp Val Arg Gln 
305                 310                 315                 320 


Ala Pro Gly Lys Gly Leu Glu Trp Tyr Ala Ala Ile Ser Tyr Asp Gly 
                325                 330                 335     


Ser Lys Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Leu Thr Ile Ser 
            340                 345                 350         


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Ser 
        355                 360                 365             


Pro Glu Asp Thr Ala Leu Tyr Phe Cys Ala Arg Gly Trp Phe Val Glu 
    370                 375                 380                 


Pro Leu Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val 
                405                 410                 415     


Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr 
            420                 425                 430         


Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
        435                 440                 445             


Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser 
    450                 455                 460                 


Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys 
465                 470                 475                 480 


Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp 
                485                 490                 495     


Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr 
            500                 505                 510         


Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
        515                 520             


<210>  68
<211>  518
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  68

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Arg Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Pro Phe Leu His Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Glu Ile Glu Leu Thr Gln Ser Pro Leu Ser Leu 
145                 150                 155                 160 


Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln 
                165                 170                 175     


Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln 
            180                 185                 190         


Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg 
        195                 200                 205             


Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr 
225                 230                 235                 240 


Tyr Cys Met Gln Ala Leu Gln Thr Phe Thr Phe Gly Pro Gly Thr Lys 
                245                 250                 255     


Val Glu Ile Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Met 
            260                 265                 270         


Ala Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu 
        275                 280                 285             


Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn 
    290                 295                 300                 


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu 
305                 310                 315                 320 


Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe Ser 
                325                 330                 335     


Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu 
            340                 345                 350         


Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro 
        355                 360                 365             


Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
385                 390                 395                 400 


Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Met 
                405                 410                 415     


Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met 
            420                 425                 430         


Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met Gly Leu 
        435                 440                 445             


Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp 
    450                 455                 460                 


Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu 
465                 470                 475                 480 


Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
                485                 490                 495     


Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Ala 
            500                 505                 510         


Gly Thr Thr Val Thr Val 
        515             


<210>  69
<211>  518
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  69

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Met Ala Asp Ile Gln Met Thr Gln Thr Thr 
            20                  25                  30          


Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg 
        35                  40                  45              


Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 
65                  70                  75                  80  


Gly Val Pro Ser Lys Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
                85                  90                  95      


Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys 
            100                 105                 110         


Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
145                 150                 155                 160 


Val Lys Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys 
            180                 185                 190         


Asn Leu Glu Trp Met Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr 
        195                 200                 205             


Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser 
    210                 215                 220                 


Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp 
                245                 250                 255     


Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Glu Pro Lys 
            260                 265                 270         


Ser Cys Asp Lys Thr His Thr Cys Pro Gln Val Gln Leu Val Gln Ser 
        275                 280                 285             


Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Arg Val Ser Cys Lys 
    290                 295                 300                 


Ala Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln 
305                 310                 315                 320 


Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe 
                325                 330                 335     


Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr 
            340                 345                 350         


Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg 
        355                 360                 365             


Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Pro Phe Leu His 
    370                 375                 380                 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Glu Leu Thr Gln Ser Pro 
                405                 410                 415     


Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg 
            420                 425                 430         


Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp 
        435                 440                 445             


Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Leu Gly 
    450                 455                 460                 


Ser Asn Arg Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 
465                 470                 475                 480 


Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val 
                485                 490                 495     


Gly Val Tyr Tyr Cys Met Gln Ala Leu Gln Thr Phe Thr Phe Gly Pro 
            500                 505                 510         


Gly Thr Lys Val Glu Ile 
        515             


<210>  70
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  70

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Val Gln Leu Val Glu Ser Gly Pro Gly 
            20                  25                  30          


Val Val Gln Pro Gly Arg Ser Leu Arg Ile Ser Cys Ala Val Ser Gly 
        35                  40                  45              


Phe Ser Val Thr Asn Tyr Gly Val His Trp Val Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ala Gly Gly Ile Thr Asn 
65                  70                  75                  80  


Tyr Asn Ser Ala Phe Met Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Ser Arg Gly Gly His Tyr Gly Tyr Ala Leu 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met 
145                 150                 155                 160 


Thr Gln Thr Pro Ala Thr Leu Ser Val Ser Ala Gly Glu Arg Val Thr 
                165                 170                 175     


Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp Val Thr Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Ser Ala Ser 
        195                 200                 205             


Asn Arg Tyr Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Tyr Gly 
    210                 215                 220                 


Thr Glu Phe Thr Phe Thr Ile Ser Ser Val Gln Ser Glu Asp Phe Ala 
225                 230                 235                 240 


Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Phe Gly Gln Gly Thr Lys 
                245                 250                 255     


Leu Glu Ile Lys Arg Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
            260                 265                 270         


Pro Met Ala Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala 
        275                 280                 285             


Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile 
    290                 295                 300                 


Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys 
305                 310                 315                 320 


Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys 
                325                 330                 335     


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn 
            340                 345                 350         


Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr 
        355                 360                 365             


Leu Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
385                 390                 395                 400 


Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
                405                 410                 415     


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            420                 425                 430         


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met 
        435                 440                 445             


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe 
    450                 455                 460                 


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
465                 470                 475                 480 


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                485                 490                 495     


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            500                 505                 510         


Gly Ala Gly Thr Thr Val Thr Val 
        515                 520 


<210>  71
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  71

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Met Ala Asp Ile Gln Met Thr Gln Thr Thr 
            20                  25                  30          


Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg 
        35                  40                  45              


Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 
65                  70                  75                  80  


Gly Val Pro Ser Lys Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
                85                  90                  95      


Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys 
            100                 105                 110         


Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
145                 150                 155                 160 


Val Lys Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys 
            180                 185                 190         


Asn Leu Glu Trp Met Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr 
        195                 200                 205             


Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser 
    210                 215                 220                 


Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp 
                245                 250                 255     


Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Glu Pro Lys 
            260                 265                 270         


Ser Cys Asp Lys Thr His Thr Cys Pro Gln Val Gln Leu Val Glu Ser 
        275                 280                 285             


Gly Pro Gly Val Val Gln Pro Gly Arg Ser Leu Arg Ile Ser Cys Ala 
    290                 295                 300                 


Val Ser Gly Phe Ser Val Thr Asn Tyr Gly Val His Trp Val Arg Gln 
305                 310                 315                 320 


Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ala Gly Gly 
                325                 330                 335     


Ile Thr Asn Tyr Asn Ser Ala Phe Met Ser Arg Leu Thr Ile Ser Lys 
            340                 345                 350         


Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala 
        355                 360                 365             


Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ser Arg Gly Gly His Tyr Gly 
    370                 375                 380                 


Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
                405                 410                 415     


Ile Val Met Thr Gln Thr Pro Ala Thr Leu Ser Val Ser Ala Gly Glu 
            420                 425                 430         


Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp Val 
        435                 440                 445             


Thr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
    450                 455                 460                 


Ser Ala Ser Asn Arg Tyr Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
465                 470                 475                 480 


Gly Tyr Gly Thr Glu Phe Thr Phe Thr Ile Ser Ser Val Gln Ser Glu 
                485                 490                 495     


Asp Phe Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Phe Gly Gln 
            500                 505                 510         


Gly Thr Lys Leu Glu Ile Lys Arg 
        515                 520 


