                         SEQUENCE LISTING

<110>  Temple University-Of The Commonwealth System of Higher 
       Education
       Li, Shuxin
 
<120>  Noninvasive AAV Vectors for Highly Efficient Gene Delivery to the
        Nervous System

<130>  206017-0208-00WO

<150>  US 63/159,502
<151>  2021-03-11

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of natural AAV9 capsid

<400>  1

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV9 7-mer insertion peptide sequence

<400>  2

Thr Leu Ala Val Pro Phe Lys 
1               5           


<210>  3
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of HEBC-AAV9 capsid

<400>  3

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Phe Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Asp Gly Thr Leu Ala Val 
            580                 585                 590         


Pro Phe Lys Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
        595                 600                 605             


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
    610                 615                 620                 


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
625                 630                 635                 640 


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
                645                 650                 655     


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
            660                 665                 670         


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
        675                 680                 685             


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
    690                 695                 700                 


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
705                 710                 715                 720 


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
                725                 730                 735     


Arg Phe Leu Thr Arg Asn Leu 
            740             


<210>  4
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIV transactivator of transcription (TAT) peptide sequence

<400>  4

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Gln 
1               5                   10          


<210>  5
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-let-7 TuD nucleic acid sequence

<400>  5
aacuauacaa ccaucuuacu accuca                                            26


<210>  6
<211>  209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lin28 amino acid sequence

<400>  6

Met Gly Ser Val Ser Asn Gln Gln Phe Ala Gly Gly Cys Ala Lys Ala 
1               5                   10                  15      


Ala Glu Lys Ala Pro Glu Glu Ala Pro Pro Asp Ala Ala Arg Ala Ala 
            20                  25                  30          


Asp Glu Pro Gln Leu Leu His Gly Ala Gly Ile Cys Lys Trp Phe Asn 
        35                  40                  45              


Val Arg Met Gly Phe Gly Phe Leu Ser Met Thr Ala Arg Ala Gly Val 
    50                  55                  60                  


Ala Leu Asp Pro Pro Val Asp Val Phe Val His Gln Ser Lys Leu His 
65                  70                  75                  80  


Met Glu Gly Phe Arg Ser Leu Lys Glu Gly Glu Ala Val Glu Phe Thr 
                85                  90                  95      


Phe Lys Lys Ser Ala Lys Gly Leu Glu Ser Ile Arg Val Thr Gly Pro 
            100                 105                 110         


Gly Gly Val Phe Cys Ile Gly Ser Glu Arg Arg Pro Lys Gly Lys Asn 
        115                 120                 125             


Met Gln Lys Arg Arg Ser Lys Gly Asp Arg Cys Tyr Asn Cys Gly Gly 
    130                 135                 140                 


Leu Asp His His Ala Lys Glu Cys Lys Leu Pro Pro Gln Pro Lys Lys 
145                 150                 155                 160 


Cys His Phe Cys Gln Ser Ile Asn His Met Val Ala Ser Cys Pro Leu 
                165                 170                 175     


Lys Ala Gln Gln Gly Pro Ser Ser Gln Gly Lys Pro Ala Tyr Phe Arg 
            180                 185                 190         


Glu Glu Glu Glu Glu Ile His Ser Pro Ala Leu Leu Pro Glu Ala Gln 
        195                 200                 205             


Asn 
    


<210>  7
<211>  855
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lin41 amino acid sequence

<400>  7

Met Ala Ser Phe Pro Glu Thr Asp Phe Gln Ile Cys Leu Leu Cys Lys 
1               5                   10                  15      


Glu Met Cys Gly Ser Pro Ala Pro Leu Ser Ser Asn Ser Ser Ala Ser 
            20                  25                  30          


Ser Ser Ser Ser Gln Thr Ser Thr Ser Ser Ala Gly Gly Gly Gly Pro 
        35                  40                  45              


Gly Ala Ala Ala Arg Arg Leu His Val Leu Pro Cys Leu His Ala Phe 
    50                  55                  60                  


Cys Arg Pro Cys Leu Glu Ala His Arg Leu Pro Ala Pro Gly Gly Ala 
65                  70                  75                  80  


Gly Pro Ala Glu Ala Leu Lys Leu Arg Cys Pro Val Cys Asp Gln Lys 
                85                  90                  95      


Val Val Leu Ala Glu Ala Ala Gly Met Asp Ala Leu Pro Ser Ser Ala 
            100                 105                 110         


Phe Leu Leu Ser Asn Leu Leu Asp Ala Val Val Ala Thr Ala Glu Glu 
        115                 120                 125             


Pro Pro Pro Lys Asn Gly Arg Ala Gly Gly Gly Pro Gly Gly Ala Gly 
    130                 135                 140                 


Gly His Ser Asn His Arg His His Ala His His Pro Ala Gln Arg Ala 
145                 150                 155                 160 


Ala Ala Pro Ala Pro Gln Pro Pro Pro Gly Pro Ala Ala Ser Pro Gly 
                165                 170                 175     


Ser Leu Leu Met Arg Arg Pro His Gly Cys Ser Ser Cys Asp Glu Gly 
            180                 185                 190         


Asn Ala Ala Ser Ser Arg Cys Leu Asp Cys Gln Glu His Leu Cys Asp 
        195                 200                 205             


Asn Cys Val Arg Ala His Gln Arg Val Arg Leu Thr Lys Asp His Tyr 
    210                 215                 220                 


Ile Glu Arg Gly Pro Pro Gly Pro Ala Ala Ala Ser Ala Ala Gln Gln 
225                 230                 235                 240 


Leu Gly Leu Gly Pro Pro Phe Ala Gly Ala Pro Phe Ser Ile Leu Ser 
                245                 250                 255     


Val Phe Pro Glu Arg Leu Gly Phe Cys Gln His His Asp Asp Glu Val 
            260                 265                 270         


Leu His Leu Tyr Cys Asp Thr Cys Ser Val Pro Ile Cys Arg Glu Cys 
        275                 280                 285             


Thr Leu Gly Arg His Gly Gly His Ser Phe Ala Tyr Leu Gln Asp Ala 
    290                 295                 300                 


Leu Gln Asp Ser Arg Ala Leu Thr Ile Gln Leu Leu Ala Asp Ala Gln 
305                 310                 315                 320 


Gln Gly Arg Gln Ala Leu Gln Leu Ser Ile Glu Gln Ala Gln Thr Val 
                325                 330                 335     


Ala Glu Gln Val Glu Met Lys Ala Lys Val Val Gln Ser Glu Val Lys 
            340                 345                 350         


Ala Val Thr Ala Arg His Lys Lys Ala Leu Glu Asp Arg Glu Cys Glu 
        355                 360                 365             


Leu Leu Trp Lys Val Glu Lys Ile Arg Gln Val Lys Ala Lys Ser Leu 
    370                 375                 380                 


Phe Leu Gln Val Glu Lys Leu Arg Gln Ser Leu Ser Lys Leu Glu Ser 
385                 390                 395                 400 


Thr Ile Ser Ala Val Gln Gln Val Leu Glu Glu Gly Arg Ala Leu Asp 
                405                 410                 415     


Ile Leu Leu Ala Arg Asp Arg Met Leu Ala Gln Val Gln Glu Leu Lys 
            420                 425                 430         


Thr Ile Arg Gly Leu Leu Gln Pro Gln Glu Asp Asp Arg Ile Met Phe 
        435                 440                 445             


Thr Pro Pro Asp Gln Ala Leu Tyr Leu Ala Leu Lys Ser Ile Gly Phe 
    450                 455                 460                 


Val Ser Ser Gly Ala Phe Ala Pro Leu Thr Lys Ala Thr Gly Asp Gly 
465                 470                 475                 480 


Ile Lys Arg Ala Leu Gln Gly Lys Val Ala Ser Phe Thr Val Met Gly 
                485                 490                 495     


Tyr Asp His Asp Gly Glu Pro Arg His Ser Gly Gly Asp Leu Met Ser 
            500                 505                 510         


Val Val Val Leu Gly Pro Asp Gly Asn Leu Phe Gly Ala Glu Val Ser 
        515                 520                 525             


Asp Gln Gln Asn Gly Thr Tyr Ile Val Ser Tyr Arg Pro Gln Leu Glu 
    530                 535                 540                 


Gly Glu His Leu Val Ser Val Thr Leu Tyr Asn Gln His Ile Glu Asn 
545                 550                 555                 560 


Ser Pro Phe Lys Val Val Val Lys Ser Gly Arg Ser Tyr Val Gly Ile 
                565                 570                 575     


Gly Leu Pro Gly Leu Ser Phe Gly Ser Glu Gly Asp Gly Glu Gly Lys 
            580                 585                 590         


Leu Cys Arg Pro Trp Gly Val Ser Val Asp Lys Glu Gly Phe Ile Ile 
        595                 600                 605             


Val Ala Asp Arg Ser Asn Asn Arg Ile Gln Val Phe Lys Pro Cys Gly 
    610                 615                 620                 


Ser Phe His His Lys Phe Gly Thr Leu Gly Ser Arg Pro Gly Gln Phe 
625                 630                 635                 640 


Asp Arg Pro Ala Gly Val Ala Cys Asp Ala Ser Arg Arg Ile Ile Val 
                645                 650                 655     


Ala Asp Lys Asp Asn His Arg Ile Gln Ile Phe Thr Phe Glu Gly Gln 
            660                 665                 670         


Phe Leu Leu Lys Phe Gly Glu Lys Gly Thr Lys Asn Gly Gln Phe Asn 
        675                 680                 685             


Tyr Pro Trp Asp Val Ala Val Asn Ser Glu Gly Lys Ile Leu Val Ser 
    690                 695                 700                 


Asp Thr Arg Asn His Arg Ile Gln Leu Phe Gly Pro Asp Gly Val Phe 
705                 710                 715                 720 


Leu Asn Lys Tyr Gly Phe Glu Gly Ser Leu Trp Lys His Phe Asp Ser 
                725                 730                 735     


Pro Arg Gly Val Ala Phe Asn Asn Glu Gly His Leu Val Val Thr Asp 
            740                 745                 750         


Phe Asn Asn His Arg Leu Leu Val Ile His Pro Asp Cys Gln Ser Ala 
        755                 760                 765             


Arg Phe Leu Gly Ser Glu Gly Ser Gly Asn Gly Gln Phe Leu Arg Pro 
    770                 775                 780                 


Gln Gly Val Ala Val Asp Gln Glu Gly Arg Ile Ile Val Ala Asp Ser 
785                 790                 795                 800 


Arg Asn His Arg Val Gln Met Phe Glu Ala Asn Gly Ser Phe Leu Cys 
                805                 810                 815     


Lys Phe Gly Ala Gln Gly Ser Gly Phe Gly Gln Met Asp Arg Pro Ser 
            820                 825                 830         


Gly Ile Ala Val Thr Pro Asp Gly Leu Ile Val Val Val Asp Phe Gly 
        835                 840                 845             


Asn Asn Arg Ile Leu Ile Phe 
    850                 855 


<210>  8
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A peptide amino acid sequence

<400>  8

Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
1               5                   10                  15      


Val Glu Glu Asn Pro Gly Pro 
            20              


<210>  9
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAR antagonist peptide amino acid sequence

<400>  9

Lys Pro Arg Ile Thr Trp Met Lys Lys Gly Lys Lys Val Ser Ser Gln 
1               5                   10                  15      


Arg Gly Gly Ser Gly Glu Thr Thr Ile Ser Gly Leu Thr Pro Glu Thr 
            20                  25                  30          


Thr Tyr Ser Ile Thr Val Ala Ala Tyr Thr Thr Lys Gly Asp Gly Ala 
        35                  40                  45              


Arg Ser Lys Pro Lys Val Val Thr Thr Thr Gly Gly Ser Gly Asp Leu 
    50                  55                  60                  


Ala Asp Asn Ile Glu Arg Leu Lys Ala Asn Asp Gly Leu Lys Phe Ser 
65                  70                  75                  80  


Gln Glu Tyr Glu Ser Ile 
                85      


<210>  10
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PTP-sigma antagonist peptide amino acid sequence

<400>  10

Lys Pro Arg Val Thr Trp Asn Lys Lys Gly Lys Lys Val Asn Ser Gln 
1               5                   10                  15      


Arg Gly Gly Ser Gly Glu Met Val Ile Thr Asn Leu Gln Pro Glu Thr 
            20                  25                  30          


Ala Tyr Ser Ile Thr Val Ala Ala Tyr Thr Met Lys Gly Asp Gly Ala 
        35                  40                  45              


Arg Ser Lys Pro Lys Val Val Val Thr Lys Gly Gly Ser Gly Asp Met 
    50                  55                  60                  


Ala Glu His Met Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys Leu Ser 
65                  70                  75                  80  


Gln Glu Tyr Glu Ser Ile 
                85      


<210>  11
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PTP-delta antagonist peptide amino acid sequence

<400>  11

Arg Pro Lys Ile Val Trp Asn Lys Lys Gly Lys Lys Val Ser Asn Gln 
1               5                   10                  15      


Arg Gly Gly Ser Gly Asp Met Ile Ile Ser Gly Leu Gln Pro Glu Thr 
            20                  25                  30          


Ser Tyr Ser Leu Thr Val Thr Ala Tyr Thr Thr Lys Gly Asp Gly Ala 
        35                  40                  45              


Arg Ser Lys Pro Lys Leu Val Ser Thr Thr Gly Gly Ser Gly Glu Leu 
    50                  55                  60                  


Ala Asp His Ile Glu Arg Leu Lys Ala Asn Asp Asn Leu Lys Phe Ser 
65                  70                  75                  80  


Gln Glu Tyr Glu Ser Ile 
                85      


