                         SEQUENCE LISTING

<110>  EXCEPGEN INC.
 
<120>  SYSTEMS AND METHODS FOR PROTEIN EXPRESSION

<130>  EXCI-002/02WO 336721-2011

<150>  US 63/160,672
<151>  2021-03-12

<160>  422   

<170>  PatentIn version 3.5

<210>  1
<211>  71
<212>  PRT
<213>  Cardiovirus Theiler's-like cardiovirus

<400>  1

Met Ala Cys Lys His Gly Tyr Pro Leu Met Cys Pro Leu Cys Thr Ala 
1               5                   10                  15      


Leu Asp Lys Thr Ser Asp Gly Leu Phe Thr Leu Leu Phe Asp Asn Glu 
            20                  25                  30          


Trp Tyr Pro Thr Asp Leu Leu Thr Val Asp Leu Glu Asp Glu Val Phe 
        35                  40                  45              


Tyr Pro Asp Asp Pro His Met Glu Trp Thr Asp Leu Pro Leu Ile Gln 
    50                  55                  60                  


Asp Ile Glu Met Glu Pro Gln 
65                  70      


<210>  2
<211>  67
<212>  PRT
<213>  Cardiovirus Encephalomyocarditis virus

<400>  2

Met Ala Thr Thr Met Glu Gln Glu Thr Cys Ala His Ser Leu Thr Phe 
1               5                   10                  15      


Glu Glu Cys Pro Lys Cys Ser Ala Leu Gln Tyr Arg Asn Gly Phe Tyr 
            20                  25                  30          


Leu Leu Lys Tyr Asp Glu Glu Trp Tyr Pro Glu Glu Leu Leu Thr Asp 
        35                  40                  45              


Gly Glu Asp Asp Val Phe Asp Pro Glu Leu Asp Met Glu Val Val Phe 
    50                  55                  60                  


Glu Leu Gln 
65          


<210>  3
<211>  127
<212>  PRT
<213>  Enterovirus Enterovirus C

<400>  3

Asn Tyr His Leu Ala Thr Gln Asp Asp Leu Gln Asn Ala Val Asn Val 
1               5                   10                  15      


Met Trp Ser Arg Asp Leu Leu Val Thr Glu Ser Arg Ala Gln Gly Thr 
            20                  25                  30          


Asp Ser Ile Ala Arg Cys Asn Cys Asn Ala Gly Val Tyr Tyr Cys Glu 
        35                  40                  45              


Ser Arg Arg Lys Tyr Tyr Pro Val Ser Phe Val Gly Pro Thr Phe Gln 
    50                  55                  60                  


Tyr Met Glu Ala Asn Asn Tyr Tyr Pro Ala Arg Tyr Gln Ser His Met 
65                  70                  75                  80  


Leu Ile Gly His Gly Phe Ala Ser Pro Gly Asp Cys Gly Gly Ile Leu 
                85                  90                  95      


Arg Cys His His Gly Val Ile Gly Ile Ile Thr Ala Gly Gly Glu Gly 
            100                 105                 110         


Leu Val Ala Phe Ser Asp Ile Arg Asp Leu Tyr Ala Tyr Glu Glu 
        115                 120                 125         


<210>  4
<211>  219
<212>  PRT
<213>  Erbovirus Equine rhinitis B virus 1

<400>  4

Met Val Thr Met Ala Gly Asn Met Ile Cys Asn Val Phe Ala Gly Leu 
1               5                   10                  15      


Ala Thr Glu Ile Cys Ser Pro Lys Gln Gly Pro Leu Leu Asp Asn Glu 
            20                  25                  30          


Leu Pro Leu Pro Leu Glu Leu Ala Glu Phe Pro Asn Lys Asp Asn Asn 
        35                  40                  45              


Cys Trp Val Ala Ala Leu Ser His Tyr Tyr Thr Leu Cys Asp Val Thr 
    50                  55                  60                  


Asn His Val Thr Lys Val Thr Pro Thr Thr Ser Gly Ile Arg Tyr Tyr 
65                  70                  75                  80  


Leu Thr Ala Trp Gln Ser Ile Leu Gln Thr Asp Leu Phe Asn Gly Tyr 
                85                  90                  95      


Tyr Pro Ala Ala Phe Ala Val Glu Thr Gly Leu Cys His Gly Pro Phe 
            100                 105                 110         


Pro Met Gln Gln His Gly Tyr Val Arg Asn Ala Thr Ser His Pro Tyr 
        115                 120                 125             


Asn Phe Cys Leu Cys Ser Glu Pro Val Pro Gly Glu Asp Tyr Trp His 
    130                 135                 140                 


Ala Val Val Lys Val Asp Leu Ser Arg Thr Glu Ala Arg Val Asp Lys 
145                 150                 155                 160 


Trp Leu Cys Ile Asp Asp Asp Arg Met Tyr Leu Ser Gly Pro Pro Thr 
                165                 170                 175     


Arg Val Lys Leu Ala Ser Ser Tyr Lys Ile Pro Thr Trp Ile Glu Ser 
            180                 185                 190         


Leu Ala Gln Phe Cys Leu Gln Leu His Pro Val Gln His Arg Arg Thr 
        195                 200                 205             


Leu Ala Asn Ser Leu Arg Asn Glu Gln Cys Arg 
    210                 215                 


<210>  5
<211>  67
<212>  PRT
<213>  Cardiovirus Encephalomyocarditis virus

<400>  5

Met Ala Thr Thr Met Glu Gln Glu Ile Cys Ala His Ser Met Thr Phe 
1               5                   10                  15      


Glu Glu Cys Pro Lys Cys Ser Ala Leu Gln Tyr Arg Asn Gly Phe Tyr 
            20                  25                  30          


Leu Leu Lys Tyr Asp Glu Glu Trp Tyr Pro Glu Glu Ser Leu Thr Asp 
        35                  40                  45              


Gly Glu Asp Asp Val Phe Asp Pro Asp Leu Asp Met Glu Val Val Phe 
    50                  55                  60                  


Glu Thr Gln 
65          


<210>  6
<211>  71
<212>  PRT
<213>  Cardiovirus Cardiovirus B

<400>  6

Met Ala Cys Lys His Gly Tyr Pro Phe Leu Cys Pro Leu Cys Thr Ala 
1               5                   10                  15      


Ile Asp Thr Thr His Asp Gly Ser Phe Thr Leu Leu Ile Asp Asn Glu 
            20                  25                  30          


Trp Tyr Pro Thr Asp Leu Leu Thr Val Asp Leu Asp Asp Asp Val Phe 
        35                  40                  45              


His Pro Asp Asp Ser Val Met Glu Trp Thr Asp Leu Pro Leu Ile Gln 
    50                  55                  60                  


Asp Val Val Met Glu Pro Gln 
65                  70      


<210>  7
<211>  149
<212>  PRT
<213>  Enterovirus Enterovirus C

<400>  7

Gly Phe Gly His Gln Asn Lys Ala Val Tyr Thr Ala Gly Tyr Lys Ile 
1               5                   10                  15      


Cys Asn Tyr His Leu Ala Thr Gln Asp Asp Leu Gln Asn Ala Val Asn 
            20                  25                  30          


Val Met Trp Ser Arg Asp Leu Leu Val Thr Glu Ser Arg Ala Gln Gly 
        35                  40                  45              


Thr Asp Ser Ile Ala Arg Cys Asn Cys Asn Ala Gly Val Tyr Tyr Cys 
    50                  55                  60                  


Glu Ser Arg Arg Lys Tyr Tyr Pro Val Ser Phe Val Gly Pro Thr Phe 
65                  70                  75                  80  


Gln Tyr Met Glu Ala Asn Asn Tyr Tyr Pro Ala Arg Tyr Gln Ser His 
                85                  90                  95      


Met Leu Ile Gly His Gly Phe Ala Ser Pro Gly Asp Cys Gly Gly Ile 
            100                 105                 110         


Leu Arg Cys His His Gly Val Ile Gly Ile Ile Thr Ala Gly Gly Glu 
        115                 120                 125             


Gly Leu Val Ala Phe Ser Asp Ile Arg Asp Leu Tyr Ala Tyr Glu Glu 
    130                 135                 140                 


Glu Ala Met Glu Gln 
145                 


<210>  8
<211>  182
<212>  PRT
<213>  Enterovirus Human rhinovirus 16

<400>  8

Gly Pro Glu Glu Glu Phe Gly Met Ser Ile Ile Lys Asn Asn Thr Cys 
1               5                   10                  15      


Val Val Thr Thr Thr Asn Gly Lys Phe Thr Gly Leu Gly Ile Tyr Asp 
            20                  25                  30          


Arg Ile Leu Ile Leu Pro Thr His Ala Asp Pro Gly Ser Glu Ile Gln 
        35                  40                  45              


Val Asn Gly Ile His Thr Lys Val Leu Asp Ser Tyr Asp Leu Phe Asn 
    50                  55                  60                  


Lys Glu Gly Val Lys Leu Glu Ile Thr Val Leu Lys Leu Asp Arg Asn 
65                  70                  75                  80  


Glu Lys Phe Arg Asp Ile Arg Lys Tyr Ile Pro Glu Ser Glu Asp Asp 
                85                  90                  95      


Tyr Pro Glu Cys Asn Leu Ala Leu Val Ala Asn Gln Thr Glu Pro Thr 
            100                 105                 110         


Ile Ile Lys Val Gly Asp Val Val Ser Tyr Gly Asn Ile Leu Leu Ser 
        115                 120                 125             


Gly Thr Gln Thr Ala Arg Met Leu Lys Tyr Asn Tyr Pro Thr Lys Ser 
    130                 135                 140                 


Gly Tyr Cys Gly Gly Val Leu Tyr Lys Ile Gly Gln Ile Leu Gly Ile 
145                 150                 155                 160 


His Val Gly Gly Asn Gly Arg Asp Gly Phe Ser Ser Met Leu Leu Arg 
                165                 170                 175     


Ser Tyr Phe Thr Glu Gln 
            180         


<210>  9
<211>  229
<212>  PRT
<213>  Vesiculovirus Indiana vesiculovirus

<400>  9

Met Ser Ser Leu Lys Lys Ile Leu Gly Leu Lys Gly Lys Gly Lys Lys 
1               5                   10                  15      


Ser Lys Lys Leu Gly Ile Ala Pro Pro Pro Tyr Glu Glu Asp Thr Ser 
            20                  25                  30          


Met Glu Tyr Ala Pro Ser Ala Pro Ile Asp Lys Ser Tyr Phe Gly Val 
        35                  40                  45              


Asp Glu Met Asp Thr Tyr Asp Pro Asn Gln Leu Arg Tyr Glu Lys Phe 
    50                  55                  60                  


Phe Phe Thr Val Lys Met Thr Val Arg Ser Asn Arg Pro Phe Arg Thr 
65                  70                  75                  80  


Tyr Ser Asp Val Ala Ala Ala Val Ser His Trp Asp His Met Tyr Ile 
                85                  90                  95      


Gly Met Ala Gly Lys Arg Pro Phe Tyr Lys Ile Leu Ala Phe Leu Gly 
            100                 105                 110         


Ser Ser Asn Leu Lys Ala Thr Pro Ala Val Leu Ala Asp Gln Gly Gln 
        115                 120                 125             


Pro Glu Tyr His Thr His Cys Glu Gly Arg Ala Tyr Leu Pro His Arg 
    130                 135                 140                 


Met Gly Lys Thr Pro Pro Met Leu Asn Val Pro Glu His Phe Arg Arg 
145                 150                 155                 160 


Pro Phe Asn Ile Gly Leu Tyr Lys Gly Thr Ile Glu Leu Thr Met Thr 
                165                 170                 175     


Ile Tyr Asp Asp Glu Ser Leu Glu Ala Ala Pro Met Ile Trp Asp His 
            180                 185                 190         


Phe Asn Ser Ser Lys Phe Ser Asp Phe Arg Glu Lys Ala Leu Met Phe 
        195                 200                 205             


Gly Leu Ile Val Glu Lys Lys Ala Ser Gly Ala Trp Val Leu Asp Ser 
    210                 215                 220                 


Ile Ser His Phe Lys 
225                 


<210>  10
<211>  230
<212>  PRT
<213>  Alphainfluenzavirus Influenza A virus

<400>  10

Met Asp Pro Asn Thr Val Ser Ser Phe Gln Val Asp Cys Phe Leu Trp 
1               5                   10                  15      


His Val Arg Lys Arg Val Ala Asp Gln Glu Leu Gly Asp Ala Pro Phe 
            20                  25                  30          


Leu Asp Arg Leu Arg Arg Asp Gln Lys Ser Leu Arg Gly Arg Gly Ser 
        35                  40                  45              


Thr Leu Gly Leu Asp Ile Glu Thr Ala Thr Arg Ala Gly Lys Gln Ile 
    50                  55                  60                  


Val Glu Arg Ile Leu Lys Glu Glu Ser Asp Glu Ala Leu Lys Met Thr 
65                  70                  75                  80  


Met Ala Ser Val Pro Ala Ser Arg Tyr Leu Thr Asp Met Thr Leu Glu 
                85                  90                  95      


Glu Met Ser Arg Asp Trp Ser Met Leu Ile Pro Lys Gln Lys Val Ala 
            100                 105                 110         


Gly Pro Leu Cys Ile Arg Met Asp Gln Ala Ile Met Asp Lys Asn Ile 
        115                 120                 125             


Ile Leu Lys Ala Asn Phe Ser Val Ile Phe Asp Arg Leu Glu Thr Leu 
    130                 135                 140                 


Ile Leu Leu Arg Ala Phe Thr Glu Glu Gly Ala Ile Val Gly Glu Ile 
145                 150                 155                 160 


Ser Pro Leu Pro Ser Leu Pro Gly His Thr Ala Glu Asp Val Lys Asn 
                165                 170                 175     


Ala Val Gly Val Leu Ile Gly Gly Leu Glu Trp Asn Asp Asn Thr Val 
            180                 185                 190         


Arg Val Ser Glu Thr Leu Gln Arg Phe Ala Trp Arg Ser Ser Asn Glu 
        195                 200                 205             


Asn Gly Arg Pro Pro Leu Thr Pro Lys Gln Lys Arg Glu Met Ala Gly 
    210                 215                 220                 


Thr Ile Arg Ser Glu Val 
225                 230 


<210>  11
<211>  512
<212>  PRT
<213>  Unknown

<220>  
<223>  Simplexvirus sp.

<400>  11

Met Ala Thr Asp Ile Asp Met Leu Ile Asp Leu Gly Leu Asp Leu Ser 
1               5                   10                  15      


Asp Ser Asp Leu Asp Glu Asp Pro Pro Glu Pro Ala Glu Ser Arg Arg 
            20                  25                  30          


Asp Asp Leu Glu Ser Asp Ser Ser Gly Glu Cys Ser Ser Ser Asp Glu 
        35                  40                  45              


Asp Met Glu Asp Pro His Gly Glu Asp Gly Pro Glu Pro Ile Leu Asp 
    50                  55                  60                  


Ala Ala Arg Pro Ala Val Arg Pro Ser Arg Pro Glu Asp Pro Gly Val 
65                  70                  75                  80  


Pro Ser Thr Gln Thr Pro Arg Pro Thr Glu Arg Gln Gly Pro Asn Asp 
                85                  90                  95      


Pro Gln Pro Ala Pro His Ser Val Trp Ser Arg Leu Gly Ala Arg Arg 
            100                 105                 110         


Pro Ser Cys Ser Pro Glu Gln His Gly Gly Lys Val Ala Arg Leu Gln 
        115                 120                 125             


Pro Pro Pro Thr Lys Ala Gln Pro Ala Arg Gly Gly Arg Arg Gly Arg 
    130                 135                 140                 


Arg Arg Gly Arg Gly Arg Gly Gly Pro Gly Ala Ala Asp Gly Leu Ser 
145                 150                 155                 160 


Asp Pro Arg Arg Arg Ala Pro Arg Thr Asn Arg Asn Pro Gly Gly Pro 
                165                 170                 175     


Arg Pro Gly Ala Gly Trp Thr Asp Gly Pro Gly Ala Pro His Gly Glu 
            180                 185                 190         


Ala Trp Arg Gly Ser Glu Gln Pro Asp Pro Pro Gly Gly Gln Arg Thr 
        195                 200                 205             


Arg Gly Val Arg Gln Ala Pro Pro Pro Leu Met Thr Leu Ala Ile Ala 
    210                 215                 220                 


Pro Pro Pro Ala Asp Pro Arg Ala Pro Ala Pro Glu Arg Lys Ala Pro 
225                 230                 235                 240 


Ala Ala Asp Thr Ile Asp Ala Thr Thr Arg Leu Val Leu Arg Ser Ile 
                245                 250                 255     


Ser Glu Arg Ala Ala Val Asp Arg Ile Ser Glu Ser Phe Gly Arg Ser 
            260                 265                 270         


Ala Gln Val Met His Asp Pro Phe Gly Gly Gln Pro Phe Pro Ala Ala 
        275                 280                 285             


Asn Ser Pro Trp Ala Pro Val Leu Ala Gly Gln Gly Gly Pro Phe Asp 
    290                 295                 300                 


Ala Glu Thr Arg Arg Val Ser Trp Glu Thr Leu Val Ala His Gly Pro 
305                 310                 315                 320 


Ser Leu Tyr Arg Thr Phe Ala Gly Asn Pro Arg Ala Ala Ser Thr Ala 
                325                 330                 335     


Lys Ala Met Arg Asp Cys Val Leu Arg Gln Glu Asn Phe Ile Glu Ala 
            340                 345                 350         


Leu Ala Ser Ala Asp Glu Thr Leu Ala Trp Cys Lys Met Cys Ile His 
        355                 360                 365             


His Asn Leu Pro Leu Arg Pro Gln Asp Pro Ile Ile Gly Thr Thr Ala 
    370                 375                 380                 


Ala Val Leu Asp Asn Leu Ala Thr Arg Leu Arg Pro Phe Leu Gln Cys 
385                 390                 395                 400 


Tyr Leu Lys Ala Arg Gly Leu Cys Gly Leu Asp Glu Leu Cys Ser Arg 
                405                 410                 415     


Arg Arg Leu Ala Asp Ile Lys Asp Ile Ala Ser Phe Val Phe Val Ile 
            420                 425                 430         


Leu Ala Arg Leu Ala Asn Arg Val Glu Arg Gly Val Ala Glu Ile Asp 
        435                 440                 445             


Tyr Ala Thr Leu Gly Val Gly Val Gly Glu Lys Met His Phe Tyr Leu 
    450                 455                 460                 


Pro Gly Ala Cys Met Ala Gly Leu Ile Glu Ile Leu Asp Thr His Arg 
465                 470                 475                 480 


Gln Glu Cys Ser Ser Arg Val Cys Glu Leu Thr Ala Ser His Ile Val 
                485                 490                 495     


Ala Pro Pro Tyr Val His Gly Lys Tyr Phe Tyr Cys Asn Ser Leu Phe 
            500                 505                 510         


<210>  12
<211>  700
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DRD1-GFP

<400>  12

Met Arg Thr Leu Asn Thr Ser Ala Met Asp Gly Thr Gly Leu Val Val 
1               5                   10                  15      


Glu Arg Asp Phe Ser Val Arg Ile Leu Thr Ala Cys Phe Leu Ser Leu 
            20                  25                  30          


Leu Ile Leu Ser Thr Leu Leu Gly Asn Thr Leu Val Cys Ala Ala Val 
        35                  40                  45              


Ile Arg Phe Arg His Leu Arg Ser Lys Val Thr Asn Phe Phe Val Ile 
    50                  55                  60                  


Ser Leu Ala Val Ser Asp Leu Leu Val Ala Val Leu Val Met Pro Trp 
65                  70                  75                  80  


Lys Ala Val Ala Glu Ile Ala Gly Phe Trp Pro Phe Gly Ser Phe Cys 
                85                  90                  95      


Asn Ile Trp Val Ala Phe Asp Ile Met Cys Ser Thr Ala Ser Ile Leu 
            100                 105                 110         


Asn Leu Cys Val Ile Ser Val Asp Arg Tyr Trp Ala Ile Ser Ser Pro 
        115                 120                 125             


Phe Arg Tyr Glu Arg Lys Met Thr Pro Lys Ala Ala Phe Ile Leu Ile 
    130                 135                 140                 


Ser Val Ala Trp Thr Leu Ser Val Leu Ile Ser Phe Ile Pro Val Gln 
145                 150                 155                 160 


Leu Ser Trp His Lys Ala Lys Pro Thr Ser Pro Ser Asp Gly Asn Ala 
                165                 170                 175     


Thr Ser Leu Ala Glu Thr Ile Asp Asn Cys Asp Ser Ser Leu Ser Arg 
            180                 185                 190         


Thr Tyr Ala Ile Ser Ser Ser Val Ile Ser Phe Tyr Ile Pro Val Ala 
        195                 200                 205             


Ile Met Ile Val Thr Tyr Thr Arg Ile Tyr Arg Ile Ala Gln Lys Gln 
    210                 215                 220                 


Ile Arg Arg Ile Ala Ala Leu Glu Arg Ala Ala Val His Ala Lys Asn 
225                 230                 235                 240 


Cys Gln Thr Thr Thr Gly Asn Gly Lys Pro Val Glu Cys Ser Gln Pro 
                245                 250                 255     


Glu Ser Ser Phe Lys Met Ser Phe Lys Arg Glu Thr Lys Val Leu Lys 
            260                 265                 270         


Thr Leu Ser Val Ile Met Gly Val Phe Val Cys Cys Trp Leu Pro Phe 
        275                 280                 285             


Phe Ile Leu Asn Cys Ile Leu Pro Phe Cys Gly Ser Gly Glu Thr Gln 
    290                 295                 300                 


Pro Phe Cys Ile Asp Ser Asn Thr Phe Asp Val Phe Val Trp Phe Gly 
305                 310                 315                 320 


Trp Ala Asn Ser Ser Leu Asn Pro Ile Ile Tyr Ala Phe Asn Ala Asp 
                325                 330                 335     


Phe Arg Lys Ala Phe Ser Thr Leu Leu Gly Cys Tyr Arg Leu Cys Pro 
            340                 345                 350         


Ala Thr Asn Asn Ala Ile Glu Thr Val Ser Ile Asn Asn Asn Gly Ala 
        355                 360                 365             


Ala Met Phe Ser Ser His His Glu Pro Arg Gly Ser Ile Ser Lys Glu 
    370                 375                 380                 


Cys Asn Leu Val Tyr Leu Ile Pro His Ala Val Gly Ser Ser Glu Asp 
385                 390                 395                 400 


Leu Lys Lys Glu Glu Ala Ala Gly Ile Ala Arg Pro Leu Glu Lys Leu 
                405                 410                 415     


Ser Pro Ala Leu Ser Val Ile Leu Asp Tyr Asp Thr Asp Val Ser Leu 
            420                 425                 430         


Glu Lys Ile Gln Pro Ile Thr Gln Asn Gly Gln His Pro Thr Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Val Ser 
    450                 455                 460                 


Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu 
465                 470                 475                 480 


Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu 
                485                 490                 495     


Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr 
            500                 505                 510         


Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr 
        515                 520                 525             


Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp 
    530                 535                 540                 


Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile 
545                 550                 555                 560 


Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe 
                565                 570                 575     


Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe 
            580                 585                 590         


Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn 
        595                 600                 605             


Ser His Lys Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys 
    610                 615                 620                 


Val Asn Phe Lys Thr Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu 
625                 630                 635                 640 


Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu 
                645                 650                 655     


Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu Ser Lys Asp 
            660                 665                 670         


Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala 
        675                 680                 685             


Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
    690                 695                 700 


<210>  13
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GFP

<400>  13

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Thr Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210>  14
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  DRD1-Strep

<400>  14

Met Arg Thr Leu Asn Thr Ser Ala Met Asp Gly Thr Gly Leu Val Val 
1               5                   10                  15      


Glu Arg Asp Phe Ser Val Arg Ile Leu Thr Ala Cys Phe Leu Ser Leu 
            20                  25                  30          


Leu Ile Leu Ser Thr Leu Leu Gly Asn Thr Leu Val Cys Ala Ala Val 
        35                  40                  45              


Ile Arg Phe Arg His Leu Arg Ser Lys Val Thr Asn Phe Phe Val Ile 
    50                  55                  60                  


Ser Leu Ala Val Ser Asp Leu Leu Val Ala Val Leu Val Met Pro Trp 
65                  70                  75                  80  


Lys Ala Val Ala Glu Ile Ala Gly Phe Trp Pro Phe Gly Ser Phe Cys 
                85                  90                  95      


Asn Ile Trp Val Ala Phe Asp Ile Met Cys Ser Thr Ala Ser Ile Leu 
            100                 105                 110         


Asn Leu Cys Val Ile Ser Val Asp Arg Tyr Trp Ala Ile Ser Ser Pro 
        115                 120                 125             


Phe Arg Tyr Glu Arg Lys Met Thr Pro Lys Ala Ala Phe Ile Leu Ile 
    130                 135                 140                 


Ser Val Ala Trp Thr Leu Ser Val Leu Ile Ser Phe Ile Pro Val Gln 
145                 150                 155                 160 


Leu Ser Trp His Lys Ala Lys Pro Thr Ser Pro Ser Asp Gly Asn Ala 
                165                 170                 175     


Thr Ser Leu Ala Glu Thr Ile Asp Asn Cys Asp Ser Ser Leu Ser Arg 
            180                 185                 190         


Thr Tyr Ala Ile Ser Ser Ser Val Ile Ser Phe Tyr Ile Pro Val Ala 
        195                 200                 205             


Ile Met Ile Val Thr Tyr Thr Arg Ile Tyr Arg Ile Ala Gln Lys Gln 
    210                 215                 220                 


Ile Arg Arg Ile Ala Ala Leu Glu Arg Ala Ala Val His Ala Lys Asn 
225                 230                 235                 240 


Cys Gln Thr Thr Thr Gly Asn Gly Lys Pro Val Glu Cys Ser Gln Pro 
                245                 250                 255     


Glu Ser Ser Phe Lys Met Ser Phe Lys Arg Glu Thr Lys Val Leu Lys 
            260                 265                 270         


Thr Leu Ser Val Ile Met Gly Val Phe Val Cys Cys Trp Leu Pro Phe 
        275                 280                 285             


Phe Ile Leu Asn Cys Ile Leu Pro Phe Cys Gly Ser Gly Glu Thr Gln 
    290                 295                 300                 


Pro Phe Cys Ile Asp Ser Asn Thr Phe Asp Val Phe Val Trp Phe Gly 
305                 310                 315                 320 


Trp Ala Asn Ser Ser Leu Asn Pro Ile Ile Tyr Ala Phe Asn Ala Asp 
                325                 330                 335     


Phe Arg Lys Ala Phe Ser Thr Leu Leu Gly Cys Tyr Arg Leu Cys Pro 
            340                 345                 350         


Ala Thr Asn Asn Ala Ile Glu Thr Val Ser Ile Asn Asn Asn Gly Ala 
        355                 360                 365             


Ala Met Phe Ser Ser His His Glu Pro Arg Gly Ser Ile Ser Lys Glu 
    370                 375                 380                 


Cys Asn Leu Val Tyr Leu Ile Pro His Ala Val Gly Ser Ser Glu Asp 
385                 390                 395                 400 


Leu Lys Lys Glu Glu Ala Ala Gly Ile Ala Arg Pro Leu Glu Lys Leu 
                405                 410                 415     


Ser Pro Ala Leu Ser Val Ile Leu Asp Tyr Asp Thr Asp Val Ser Leu 
            420                 425                 430         


Glu Lys Ile Gln Pro Ile Thr Gln Asn Gly Gln His Pro Thr Thr Gly 
        435                 440                 445             


Thr Arg Pro Leu Trp Ser His Pro Gln Phe Glu Lys 
    450                 455                 460 


<210>  15
<211>  635
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  ITK

<400>  15

Met Asn Asn Phe Ile Leu Leu Glu Glu Gln Leu Ile Lys Lys Ser Gln 
1               5                   10                  15      


Gln Lys Arg Arg Thr Ser Pro Ser Asn Phe Lys Val Arg Phe Phe Val 
            20                  25                  30          


Leu Thr Lys Ala Ser Leu Ala Tyr Phe Glu Asp Arg His Gly Lys Lys 
        35                  40                  45              


Arg Thr Leu Lys Gly Ser Ile Glu Leu Ser Arg Ile Lys Cys Val Glu 
    50                  55                  60                  


Ile Val Lys Ser Asp Ile Ser Ile Pro Cys His Tyr Lys Tyr Pro Phe 
65                  70                  75                  80  


Gln Val Val His Asp Asn Tyr Leu Leu Tyr Val Phe Ala Pro Asp Arg 
                85                  90                  95      


Glu Ser Arg Gln Arg Trp Val Leu Ala Leu Lys Glu Glu Thr Arg Asn 
            100                 105                 110         


Asn Asn Ser Leu Val Pro Lys Tyr His Pro Asn Phe Trp Met Asp Gly 
        115                 120                 125             


Lys Trp Arg Cys Cys Ser Gln Leu Glu Lys Leu Ala Thr Gly Cys Ala 
    130                 135                 140                 


Gln Tyr Asp Pro Thr Lys Asn Ala Ser Lys Lys Pro Leu Pro Pro Thr 
145                 150                 155                 160 


Pro Glu Asp Asn Arg Arg Pro Leu Trp Glu Pro Glu Glu Thr Val Val 
                165                 170                 175     


Ile Ala Leu Tyr Asp Tyr Gln Thr Asn Asp Pro Gln Glu Leu Ala Leu 
            180                 185                 190         


Arg Arg Asn Glu Glu Tyr Cys Leu Leu Asp Ser Ser Glu Ile His Trp 
        195                 200                 205             


Trp Arg Val Gln Asp Arg Asn Gly His Glu Gly Tyr Val Pro Ser Ser 
    210                 215                 220                 


Tyr Leu Val Glu Lys Ser Pro Asn Asn Leu Glu Thr Tyr Glu Trp Tyr 
225                 230                 235                 240 


Asn Lys Ser Ile Ser Arg Asp Lys Ala Glu Lys Leu Leu Leu Asp Thr 
                245                 250                 255     


Gly Lys Glu Gly Ala Phe Met Val Arg Asp Ser Arg Thr Ala Gly Thr 
            260                 265                 270         


Tyr Thr Val Ser Val Phe Thr Lys Ala Val Val Ser Glu Asn Asn Pro 
        275                 280                 285             


Cys Ile Lys His Tyr His Ile Lys Glu Thr Asn Asp Asn Pro Lys Arg 
    290                 295                 300                 


Tyr Tyr Val Ala Glu Lys Tyr Val Phe Asp Ser Ile Pro Leu Leu Ile 
305                 310                 315                 320 


Asn Tyr His Gln His Asn Gly Gly Gly Leu Val Thr Arg Leu Arg Tyr 
                325                 330                 335     


Pro Val Cys Phe Gly Arg Gln Lys Ala Pro Val Thr Ala Gly Leu Arg 
            340                 345                 350         


Tyr Gly Lys Trp Val Ile Asp Pro Ser Glu Leu Thr Phe Val Gln Glu 
        355                 360                 365             


Ile Gly Ser Gly Gln Phe Gly Leu Val His Leu Gly Tyr Trp Leu Asn 
    370                 375                 380                 


Lys Asp Lys Val Ala Ile Lys Thr Ile Arg Glu Gly Ala Met Ser Glu 
385                 390                 395                 400 


Glu Asp Phe Ile Glu Glu Ala Glu Val Met Met Lys Leu Ser His Pro 
                405                 410                 415     


Lys Leu Val Gln Leu Tyr Gly Val Cys Leu Glu Gln Ala Pro Ile Cys 
            420                 425                 430         


Leu Val Phe Glu Phe Met Glu His Gly Cys Leu Ser Asp Tyr Leu Arg 
        435                 440                 445             


Thr Gln Arg Gly Leu Phe Ala Ala Glu Thr Leu Leu Gly Met Cys Leu 
    450                 455                 460                 


Asp Val Cys Glu Gly Met Ala Tyr Leu Glu Glu Ala Cys Val Ile His 
465                 470                 475                 480 


Arg Asp Leu Ala Ala Arg Asn Cys Leu Val Gly Glu Asn Gln Val Ile 
                485                 490                 495     


Lys Val Ser Asp Phe Gly Met Thr Arg Phe Val Leu Asp Asp Gln Tyr 
            500                 505                 510         


Thr Ser Ser Thr Gly Thr Lys Phe Pro Val Lys Trp Ala Ser Pro Glu 
        515                 520                 525             


Val Phe Ser Phe Ser Arg Tyr Ser Ser Lys Ser Asp Val Trp Ser Phe 
    530                 535                 540                 


Gly Val Leu Met Trp Glu Val Phe Ser Glu Gly Lys Ile Pro Tyr Glu 
545                 550                 555                 560 


Asn Arg Ser Asn Ser Glu Val Val Glu Asp Ile Ser Thr Gly Phe Arg 
                565                 570                 575     


Leu Tyr Lys Pro Arg Leu Ala Ser Thr His Val Tyr Gln Ile Met Asn 
            580                 585                 590         


His Cys Trp Lys Glu Arg Pro Glu Asp Arg Pro Ala Phe Ser Arg Leu 
        595                 600                 605             


Leu Arg Gln Leu Ala Glu Ile Ala Glu Ser Gly Leu Gly Gly Gly Gly 
    610                 615                 620                 


Gly Gly Gly Gly His His His His His His Val 
625                 630                 635 


<210>  16
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  C1 Inhibitor

<400>  16

Met Ala Ser Arg Leu Thr Leu Leu Thr Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Gly Asp Arg Ala Ser Ser Asn Pro Asn Ala Thr Ser Ser Ser Ser Gln 
            20                  25                  30          


Asp Pro Glu Ser Leu Gln Asp Arg Gly Glu Gly Lys Val Ala Thr Thr 
        35                  40                  45              


Val Ile Ser Lys Met Leu Phe Val Glu Pro Ile Leu Glu Val Ser Ser 
    50                  55                  60                  


Leu Pro Thr Thr Asn Ser Thr Thr Asn Ser Ala Thr Lys Ile Thr Ala 
65                  70                  75                  80  


Asn Thr Thr Asp Glu Pro Thr Thr Gln Pro Thr Thr Glu Pro Thr Thr 
                85                  90                  95      


Gln Pro Thr Ile Gln Pro Thr Gln Pro Thr Thr Gln Leu Pro Thr Asp 
            100                 105                 110         


Ser Pro Thr Gln Pro Thr Thr Gly Ser Phe Cys Pro Gly Pro Val Thr 
        115                 120                 125             


Leu Cys Ser Asp Leu Glu Ser His Ser Thr Glu Ala Val Leu Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Phe Ser Leu Lys Leu Tyr His Ala Phe Ser Ala Met 
145                 150                 155                 160 


Lys Lys Val Glu Thr Asn Met Ala Phe Ser Pro Phe Ser Ile Ala Ser 
                165                 170                 175     


Leu Leu Thr Gln Val Leu Leu Gly Ala Gly Glu Asn Thr Lys Thr Asn 
            180                 185                 190         


Leu Glu Ser Ile Leu Ser Tyr Pro Lys Asp Phe Thr Cys Val His Gln 
        195                 200                 205             


Ala Leu Lys Gly Phe Thr Thr Lys Gly Val Thr Ser Val Ser Gln Ile 
    210                 215                 220                 


Phe His Ser Pro Asp Leu Ala Ile Arg Asp Thr Phe Val Asn Ala Ser 
225                 230                 235                 240 


Arg Thr Leu Tyr Ser Ser Ser Pro Arg Val Leu Ser Asn Asn Ser Asp 
                245                 250                 255     


Ala Asn Leu Glu Leu Ile Asn Thr Trp Val Ala Lys Asn Thr Asn Asn 
            260                 265                 270         


Lys Ile Ser Arg Leu Leu Asp Ser Leu Pro Ser Asp Thr Arg Leu Val 
        275                 280                 285             


Leu Leu Asn Ala Ile Tyr Leu Ser Ala Lys Trp Lys Thr Thr Phe Asp 
    290                 295                 300                 


Pro Lys Lys Thr Arg Met Glu Pro Phe His Phe Lys Asn Ser Val Ile 
305                 310                 315                 320 


Lys Val Pro Met Met Asn Ser Lys Lys Tyr Pro Val Ala His Phe Ile 
                325                 330                 335     


Asp Gln Thr Leu Lys Ala Lys Val Gly Gln Leu Gln Leu Ser His Asn 
            340                 345                 350         


Leu Ser Leu Val Ile Leu Val Pro Gln Asn Leu Lys His Arg Leu Glu 
        355                 360                 365             


Asp Met Glu Gln Ala Leu Ser Pro Ser Val Phe Lys Ala Ile Met Glu 
    370                 375                 380                 


Lys Leu Glu Met Ser Lys Phe Gln Pro Thr Leu Leu Thr Leu Pro Arg 
385                 390                 395                 400 


Ile Lys Val Thr Thr Ser Gln Asp Met Leu Ser Ile Met Glu Lys Leu 
                405                 410                 415     


Glu Phe Phe Asp Phe Ser Tyr Asp Leu Asn Leu Cys Gly Leu Thr Glu 
            420                 425                 430         


Asp Pro Asp Leu Gln Val Ser Ala Met Gln His Gln Thr Val Leu Glu 
        435                 440                 445             


Leu Thr Glu Thr Gly Val Glu Ala Ala Ala Ala Ser Ala Ile Ser Val 
    450                 455                 460                 


Ala Arg Thr Leu Leu Val Phe Glu Val Gln Gln Pro Phe Leu Phe Val 
465                 470                 475                 480 


Leu Trp Asp Gln Gln His Lys Phe Pro Val Phe Met Gly Arg Val Tyr 
                485                 490                 495     


Asp Pro Arg Ala 
            500 


<210>  17
<211>  883
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  T7 RNA polymerase

<400>  17

Met Asn Thr Ile Asn Ile Ala Lys Asn Asp Phe Ser Asp Ile Glu Leu 
1               5                   10                  15      


Ala Ala Ile Pro Phe Asn Thr Leu Ala Asp His Tyr Gly Glu Arg Leu 
            20                  25                  30          


Ala Arg Glu Gln Leu Ala Leu Glu His Glu Ser Tyr Glu Met Gly Glu 
        35                  40                  45              


Ala Arg Phe Arg Lys Met Phe Glu Arg Gln Leu Lys Ala Gly Glu Val 
    50                  55                  60                  


Ala Asp Asn Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu Leu Pro Lys 
65                  70                  75                  80  


Met Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu Val Lys Ala Lys Arg 
                85                  90                  95      


Gly Lys Arg Pro Thr Ala Phe Gln Phe Leu Gln Glu Ile Lys Pro Glu 
            100                 105                 110         


Ala Val Ala Tyr Ile Thr Ile Lys Thr Thr Leu Ala Cys Leu Thr Ser 
        115                 120                 125             


Ala Asp Asn Thr Thr Val Gln Ala Val Ala Ser Ala Ile Gly Arg Ala 
    130                 135                 140                 


Ile Glu Asp Glu Ala Arg Phe Gly Arg Ile Arg Asp Leu Glu Ala Lys 
145                 150                 155                 160 


His Phe Lys Lys Asn Val Glu Glu Gln Leu Asn Lys Arg Val Gly His 
                165                 170                 175     


Val Tyr Lys Lys Ala Phe Met Gln Val Val Glu Ala Asp Met Leu Ser 
            180                 185                 190         


Lys Gly Leu Leu Gly Gly Glu Ala Trp Ser Ser Trp His Lys Glu Asp 
        195                 200                 205             


Ser Ile His Val Gly Val Arg Cys Ile Glu Met Leu Ile Glu Ser Thr 
    210                 215                 220                 


Gly Met Val Ser Leu His Arg Gln Asn Ala Gly Val Val Gly Gln Asp 
225                 230                 235                 240 


Ser Glu Thr Ile Glu Leu Ala Pro Glu Tyr Ala Glu Ala Ile Ala Thr 
                245                 250                 255     


Arg Ala Gly Ala Leu Ala Gly Ile Ser Pro Met Phe Gln Pro Cys Val 
            260                 265                 270         


Val Pro Pro Lys Pro Trp Thr Gly Ile Thr Gly Gly Gly Tyr Trp Ala 
        275                 280                 285             


Asn Gly Arg Arg Pro Leu Ala Leu Val Arg Thr His Ser Lys Lys Ala 
    290                 295                 300                 


Leu Met Arg Tyr Glu Asp Val Tyr Met Pro Glu Val Tyr Lys Ala Ile 
305                 310                 315                 320 


Asn Ile Ala Gln Asn Thr Ala Trp Lys Ile Asn Lys Lys Val Leu Ala 
                325                 330                 335     


Val Ala Asn Val Ile Thr Lys Trp Lys His Cys Pro Val Glu Asp Ile 
            340                 345                 350         


Pro Ala Ile Glu Arg Glu Glu Leu Pro Met Lys Pro Glu Asp Ile Asp 
        355                 360                 365             


Met Asn Pro Glu Ala Leu Thr Ala Trp Lys Arg Ala Ala Ala Ala Val 
    370                 375                 380                 


Tyr Arg Lys Asp Lys Ala Arg Lys Ser Arg Arg Ile Ser Leu Glu Phe 
385                 390                 395                 400 


Met Leu Glu Gln Ala Asn Lys Phe Ala Asn His Lys Ala Ile Trp Phe 
                405                 410                 415     


Pro Tyr Asn Met Asp Trp Arg Gly Arg Val Tyr Ala Val Ser Met Phe 
            420                 425                 430         


Asn Pro Gln Gly Asn Asp Met Thr Lys Gly Leu Leu Thr Leu Ala Lys 
        435                 440                 445             


Gly Lys Pro Ile Gly Lys Glu Gly Tyr Tyr Trp Leu Lys Ile His Gly 
    450                 455                 460                 


Ala Asn Cys Ala Gly Val Asp Lys Val Pro Phe Pro Glu Arg Ile Lys 
465                 470                 475                 480 


Phe Ile Glu Glu Asn His Glu Asn Ile Met Ala Cys Ala Lys Ser Pro 
                485                 490                 495     


Leu Glu Asn Thr Trp Trp Ala Glu Gln Asp Ser Pro Phe Cys Phe Leu 
            500                 505                 510         


Ala Phe Cys Phe Glu Tyr Ala Gly Val Gln His His Gly Leu Ser Tyr 
        515                 520                 525             


Asn Cys Ser Leu Pro Leu Ala Phe Asp Gly Ser Cys Ser Gly Ile Gln 
    530                 535                 540                 


His Phe Ser Ala Met Leu Arg Asp Glu Val Gly Gly Arg Ala Val Asn 
545                 550                 555                 560 


Leu Leu Pro Ser Glu Thr Val Gln Asp Ile Tyr Gly Ile Val Ala Lys 
                565                 570                 575     


Lys Val Asn Glu Ile Leu Gln Ala Asp Ala Ile Asn Gly Thr Asp Asn 
            580                 585                 590         


Glu Val Val Thr Val Thr Asp Glu Asn Thr Gly Glu Ile Ser Glu Lys 
        595                 600                 605             


Val Lys Leu Gly Thr Lys Ala Leu Ala Gly Gln Trp Leu Ala Tyr Gly 
    610                 615                 620                 


Val Thr Arg Ser Val Thr Lys Arg Ser Val Met Thr Leu Ala Tyr Gly 
625                 630                 635                 640 


Ser Lys Glu Phe Gly Phe Arg Gln Gln Val Leu Glu Asp Thr Ile Gln 
                645                 650                 655     


Pro Ala Ile Asp Ser Gly Lys Gly Leu Met Phe Thr Gln Pro Asn Gln 
            660                 665                 670         


Ala Ala Gly Tyr Met Ala Lys Leu Ile Trp Glu Ser Val Ser Val Thr 
        675                 680                 685             


Val Val Ala Ala Val Glu Ala Met Asn Trp Leu Lys Ser Ala Ala Lys 
    690                 695                 700                 


Leu Leu Ala Ala Glu Val Lys Asp Lys Lys Thr Gly Glu Ile Leu Arg 
705                 710                 715                 720 


Lys Arg Cys Ala Val His Trp Val Thr Pro Asp Gly Phe Pro Val Trp 
                725                 730                 735     


Gln Glu Tyr Lys Lys Pro Ile Gln Thr Arg Leu Asn Leu Met Phe Leu 
            740                 745                 750         


Gly Gln Phe Arg Leu Gln Pro Thr Ile Asn Thr Asn Lys Asp Ser Glu 
        755                 760                 765             


Ile Asp Ala His Lys Gln Glu Ser Gly Ile Ala Pro Asn Phe Val His 
    770                 775                 780                 


Ser Gln Asp Gly Ser His Leu Arg Lys Thr Val Val Trp Ala His Glu 
785                 790                 795                 800 


Lys Tyr Gly Ile Glu Ser Phe Ala Leu Ile His Asp Ser Phe Gly Thr 
                805                 810                 815     


Ile Pro Ala Asp Ala Ala Asn Leu Phe Lys Ala Val Arg Glu Thr Met 
            820                 825                 830         


Val Asp Thr Tyr Glu Ser Cys Asp Val Leu Ala Asp Phe Tyr Asp Gln 
        835                 840                 845             


Phe Ala Asp Gln Leu His Glu Ser Gln Leu Asp Lys Met Pro Ala Leu 
    850                 855                 860                 


Pro Ala Lys Gly Asn Leu Asn Leu Arg Asp Ile Leu Glu Ser Asp Phe 
865                 870                 875                 880 


Ala Phe Ala 
            


<210>  18
<211>  1480
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CFTR

<400>  18

Met Gln Arg Ser Pro Leu Glu Lys Ala Ser Val Val Ser Lys Leu Phe 
1               5                   10                  15      


Phe Ser Trp Thr Arg Pro Ile Leu Arg Lys Gly Tyr Arg Gln Arg Leu 
            20                  25                  30          


Glu Leu Ser Asp Ile Tyr Gln Ile Pro Ser Val Asp Ser Ala Asp Asn 
        35                  40                  45              


Leu Ser Glu Lys Leu Glu Arg Glu Trp Asp Arg Glu Leu Ala Ser Lys 
    50                  55                  60                  


Lys Asn Pro Lys Leu Ile Asn Ala Leu Arg Arg Cys Phe Phe Trp Arg 
65                  70                  75                  80  


Phe Met Phe Tyr Gly Ile Phe Leu Tyr Leu Gly Glu Val Thr Lys Ala 
                85                  90                  95      


Val Gln Pro Leu Leu Leu Gly Arg Ile Ile Ala Ser Tyr Asp Pro Asp 
            100                 105                 110         


Asn Lys Glu Glu Arg Ser Ile Ala Ile Tyr Leu Gly Ile Gly Leu Cys 
        115                 120                 125             


Leu Leu Phe Ile Val Arg Thr Leu Leu Leu His Pro Ala Ile Phe Gly 
    130                 135                 140                 


Leu His His Ile Gly Met Gln Met Arg Ile Ala Met Phe Ser Leu Ile 
145                 150                 155                 160 


Tyr Lys Lys Thr Leu Lys Leu Ser Ser Arg Val Leu Asp Lys Ile Ser 
                165                 170                 175     


Ile Gly Gln Leu Val Ser Leu Leu Ser Asn Asn Leu Asn Lys Phe Asp 
            180                 185                 190         


Glu Gly Leu Ala Leu Ala His Phe Val Trp Ile Ala Pro Leu Gln Val 
        195                 200                 205             


Ala Leu Leu Met Gly Leu Ile Trp Glu Leu Leu Gln Ala Ser Ala Phe 
    210                 215                 220                 


Cys Gly Leu Gly Phe Leu Ile Val Leu Ala Leu Phe Gln Ala Gly Leu 
225                 230                 235                 240 


Gly Arg Met Met Met Lys Tyr Arg Asp Gln Arg Ala Gly Lys Ile Ser 
                245                 250                 255     


Glu Arg Leu Val Ile Thr Ser Glu Met Ile Glu Asn Ile Gln Ser Val 
            260                 265                 270         


Lys Ala Tyr Cys Trp Glu Glu Ala Met Glu Lys Met Ile Glu Asn Leu 
        275                 280                 285             


Arg Gln Thr Glu Leu Lys Leu Thr Arg Lys Ala Ala Tyr Val Arg Tyr 
    290                 295                 300                 


Phe Asn Ser Ser Ala Phe Phe Phe Ser Gly Phe Phe Val Val Phe Leu 
305                 310                 315                 320 


Ser Val Leu Pro Tyr Ala Leu Ile Lys Gly Ile Ile Leu Arg Lys Ile 
                325                 330                 335     


Phe Thr Thr Ile Ser Phe Cys Ile Val Leu Arg Met Ala Val Thr Arg 
            340                 345                 350         


Gln Phe Pro Trp Ala Val Gln Thr Trp Tyr Asp Ser Leu Gly Ala Ile 
        355                 360                 365             


Asn Lys Ile Gln Asp Phe Leu Gln Lys Gln Glu Tyr Lys Thr Leu Glu 
    370                 375                 380                 


Tyr Asn Leu Thr Thr Thr Glu Val Val Met Glu Asn Val Thr Ala Phe 
385                 390                 395                 400 


Trp Glu Glu Gly Phe Gly Glu Leu Phe Glu Lys Ala Lys Gln Asn Asn 
                405                 410                 415     


Asn Asn Arg Lys Thr Ser Asn Gly Asp Asp Ser Leu Phe Phe Ser Asn 
            420                 425                 430         


Phe Ser Leu Leu Gly Thr Pro Val Leu Lys Asp Ile Asn Phe Lys Ile 
        435                 440                 445             


Glu Arg Gly Gln Leu Leu Ala Val Ala Gly Ser Thr Gly Ala Gly Lys 
    450                 455                 460                 


Thr Ser Leu Leu Met Met Ile Met Gly Glu Leu Glu Pro Ser Glu Gly 
465                 470                 475                 480 


Lys Ile Lys His Ser Gly Arg Ile Ser Phe Cys Ser Gln Phe Ser Trp 
                485                 490                 495     


Ile Met Pro Gly Thr Ile Lys Glu Asn Ile Ile Phe Gly Val Ser Tyr 
            500                 505                 510         


Asp Glu Tyr Arg Tyr Arg Ser Val Ile Lys Ala Cys Gln Leu Glu Glu 
        515                 520                 525             


Asp Ile Ser Lys Phe Ala Glu Lys Asp Asn Ile Val Leu Gly Glu Gly 
    530                 535                 540                 


Gly Ile Thr Leu Ser Gly Gly Gln Arg Ala Arg Ile Ser Leu Ala Arg 
545                 550                 555                 560 


Ala Val Tyr Lys Asp Ala Asp Leu Tyr Leu Leu Asp Ser Pro Phe Gly 
                565                 570                 575     


Tyr Leu Asp Val Leu Thr Glu Lys Glu Ile Phe Glu Ser Cys Val Cys 
            580                 585                 590         


Lys Leu Met Ala Asn Lys Thr Arg Ile Leu Val Thr Ser Lys Met Glu 
        595                 600                 605             


His Leu Lys Lys Ala Asp Lys Ile Leu Ile Leu His Glu Gly Ser Ser 
    610                 615                 620                 


Tyr Phe Tyr Gly Thr Phe Ser Glu Leu Gln Asn Leu Gln Pro Asp Phe 
625                 630                 635                 640 


Ser Ser Lys Leu Met Gly Cys Asp Ser Phe Asp Gln Phe Ser Ala Glu 
                645                 650                 655     


Arg Arg Asn Ser Ile Leu Thr Glu Thr Leu His Arg Phe Ser Leu Glu 
            660                 665                 670         


Gly Asp Ala Pro Val Ser Trp Thr Glu Thr Lys Lys Gln Ser Phe Lys 
        675                 680                 685             


Gln Thr Gly Glu Phe Gly Glu Lys Arg Lys Asn Ser Ile Leu Asn Pro 
    690                 695                 700                 


Ile Asn Ser Ile Arg Lys Phe Ser Ile Val Gln Lys Thr Pro Leu Gln 
705                 710                 715                 720 


Met Asn Gly Ile Glu Glu Asp Ser Asp Glu Pro Leu Glu Arg Arg Leu 
                725                 730                 735     


Ser Leu Val Pro Asp Ser Glu Gln Gly Glu Ala Ile Leu Pro Arg Ile 
            740                 745                 750         


Ser Val Ile Ser Thr Gly Pro Thr Leu Gln Ala Arg Arg Arg Gln Ser 
        755                 760                 765             


Val Leu Asn Leu Met Thr His Ser Val Asn Gln Gly Gln Asn Ile His 
    770                 775                 780                 


Arg Lys Thr Thr Ala Ser Thr Arg Lys Val Ser Leu Ala Pro Gln Ala 
785                 790                 795                 800 


Asn Leu Thr Glu Leu Asp Ile Tyr Ser Arg Arg Leu Ser Gln Glu Thr 
                805                 810                 815     


Gly Leu Glu Ile Ser Glu Glu Ile Asn Glu Glu Asp Leu Lys Glu Cys 
            820                 825                 830         


Leu Phe Asp Asp Met Glu Ser Ile Pro Ala Val Thr Thr Trp Asn Thr 
        835                 840                 845             


Tyr Leu Arg Tyr Ile Thr Val His Lys Ser Leu Ile Phe Val Leu Ile 
    850                 855                 860                 


Trp Cys Leu Val Ile Phe Leu Ala Glu Val Ala Ala Ser Leu Val Val 
865                 870                 875                 880 


Leu Trp Leu Leu Gly Asn Thr Pro Leu Gln Asp Lys Gly Asn Ser Thr 
                885                 890                 895     


His Ser Arg Asn Asn Ser Tyr Ala Val Ile Ile Thr Ser Thr Ser Ser 
            900                 905                 910         


Tyr Tyr Val Phe Tyr Ile Tyr Val Gly Val Ala Asp Thr Leu Leu Ala 
        915                 920                 925             


Met Gly Phe Phe Arg Gly Leu Pro Leu Val His Thr Leu Ile Thr Val 
    930                 935                 940                 


Ser Lys Ile Leu His His Lys Met Leu His Ser Val Leu Gln Ala Pro 
945                 950                 955                 960 


Met Ser Thr Leu Asn Thr Leu Lys Ala Gly Gly Ile Leu Asn Arg Phe 
                965                 970                 975     


Ser Lys Asp Ile Ala Ile Leu Asp Asp Leu Leu Pro Leu Thr Ile Phe 
            980                 985                 990         


Asp Phe Ile Gln Leu Leu Leu Ile  Val Ile Gly Ala Ile  Ala Val Val 
        995                 1000                 1005             


Ala Val  Leu Gln Pro Tyr Ile  Phe Val Ala Thr Val  Pro Val Ile 
    1010                 1015                 1020             


Val Ala  Phe Ile Met Leu Arg  Ala Tyr Phe Leu Gln  Thr Ser Gln 
    1025                 1030                 1035             


Gln Leu  Lys Gln Leu Glu Ser  Glu Gly Arg Ser Pro  Ile Phe Thr 
    1040                 1045                 1050             


His Leu  Val Thr Ser Leu Lys  Gly Leu Trp Thr Leu  Arg Ala Phe 
    1055                 1060                 1065             


Gly Arg  Gln Pro Tyr Phe Glu  Thr Leu Phe His Lys  Ala Leu Asn 
    1070                 1075                 1080             


Leu His  Thr Ala Asn Trp Phe  Leu Tyr Leu Ser Thr  Leu Arg Trp 
    1085                 1090                 1095             


Phe Gln  Met Arg Ile Glu Met  Ile Phe Val Ile Phe  Phe Ile Ala 
    1100                 1105                 1110             


Val Thr  Phe Ile Ser Ile Leu  Thr Thr Gly Glu Gly  Glu Gly Arg 
    1115                 1120                 1125             


Val Gly  Ile Ile Leu Thr Leu  Ala Met Asn Ile Met  Ser Thr Leu 
    1130                 1135                 1140             


Gln Trp  Ala Val Asn Ser Ser  Ile Asp Val Asp Ser  Leu Met Arg 
    1145                 1150                 1155             


Ser Val  Ser Arg Val Phe Lys  Phe Ile Asp Met Pro  Thr Glu Gly 
    1160                 1165                 1170             


Lys Pro  Thr Lys Ser Thr Lys  Pro Tyr Lys Asn Gly  Gln Leu Ser 
    1175                 1180                 1185             


Lys Val  Met Ile Ile Glu Asn  Ser His Val Lys Lys  Asp Asp Ile 
    1190                 1195                 1200             


Trp Pro  Ser Gly Gly Gln Met  Thr Val Lys Asp Leu  Thr Ala Lys 
    1205                 1210                 1215             


Tyr Thr  Glu Gly Gly Asn Ala  Ile Leu Glu Asn Ile  Ser Phe Ser 
    1220                 1225                 1230             


Ile Ser  Pro Gly Gln Arg Val  Gly Leu Leu Gly Arg  Thr Gly Ser 
    1235                 1240                 1245             


Gly Lys  Ser Thr Leu Leu Ser  Ala Phe Leu Arg Leu  Leu Asn Thr 
    1250                 1255                 1260             


Glu Gly  Glu Ile Gln Ile Asp  Gly Val Ser Trp Asp  Ser Ile Thr 
    1265                 1270                 1275             


Leu Gln  Gln Trp Arg Lys Ala  Phe Gly Val Ile Pro  Gln Lys Val 
    1280                 1285                 1290             


Phe Ile  Phe Ser Gly Thr Phe  Arg Lys Asn Leu Asp  Pro Tyr Glu 
    1295                 1300                 1305             


Gln Trp  Ser Asp Gln Glu Ile  Trp Lys Val Ala Asp  Glu Val Gly 
    1310                 1315                 1320             


Leu Arg  Ser Val Ile Glu Gln  Phe Pro Gly Lys Leu  Asp Phe Val 
    1325                 1330                 1335             


Leu Val  Asp Gly Gly Cys Val  Leu Ser His Gly His  Lys Gln Leu 
    1340                 1345                 1350             


Met Cys  Leu Ala Arg Ser Val  Leu Ser Lys Ala Lys  Ile Leu Leu 
    1355                 1360                 1365             


Leu Asp  Glu Pro Ser Ala His  Leu Asp Pro Val Thr  Tyr Gln Ile 
    1370                 1375                 1380             


Ile Arg  Arg Thr Leu Lys Gln  Ala Phe Ala Asp Cys  Thr Val Ile 
    1385                 1390                 1395             


Leu Cys  Glu His Arg Ile Glu  Ala Met Leu Glu Cys  Gln Gln Phe 
    1400                 1405                 1410             


Leu Val  Ile Glu Glu Asn Lys  Val Arg Gln Tyr Asp  Ser Ile Gln 
    1415                 1420                 1425             


Lys Leu  Leu Asn Glu Arg Ser  Leu Phe Arg Gln Ala  Ile Ser Pro 
    1430                 1435                 1440             


Ser Asp  Arg Val Lys Leu Phe  Pro His Arg Asn Ser  Ser Lys Cys 
    1445                 1450                 1455             


Lys Ser  Lys Pro Gln Ile Ala  Ala Leu Lys Glu Glu  Thr Glu Glu 
    1460                 1465                 1470             


Glu Val  Gln Asp Thr Arg Leu  
    1475                 1480 


<210>  19
<211>  550
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Luciferase insert sequence

<400>  19

Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro 
1               5                   10                  15      


Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg 
            20                  25                  30          


Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu 
        35                  40                  45              


Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala 
    50                  55                  60                  


Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val 
65                  70                  75                  80  


Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu 
                85                  90                  95      


Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg 
            100                 105                 110         


Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val 
        115                 120                 125             


Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro 
    130                 135                 140                 


Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly 
145                 150                 155                 160 


Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe 
                165                 170                 175     


Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile 
            180                 185                 190         


Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
        195                 200                 205             


Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp 
    210                 215                 220                 


Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
225                 230                 235                 240 


Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu 
                245                 250                 255     


Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu 
            260                 265                 270         


Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val 
        275                 280                 285             


Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr 
    290                 295                 300                 


Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser 
305                 310                 315                 320 


Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile 
                325                 330                 335     


Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr 
            340                 345                 350         


Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe 
        355                 360                 365             


Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val 
    370                 375                 380                 


Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly 
385                 390                 395                 400 


Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly 
                405                 410                 415     


Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe 
            420                 425                 430         


Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
        435                 440                 445             


Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile 
    450                 455                 460                 


Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
465                 470                 475                 480 


Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys 
                485                 490                 495     


Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu 
            500                 505                 510         


Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly 
        515                 520                 525             


Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys 
    530                 535                 540                 


Gly Gly Lys Ile Ala Val 
545                 550 


<210>  20
<211>  2237
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Luciferase insert sequence

<400>  20
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggactatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc      420

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt      480

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa      540

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctatggaa gatgccaaaa      600

acattaagaa gggcccagcg ccattctacc cactcgaaga cgggaccgcc ggcgagcagc      660

tgcacaaagc catgaagcgc tacgccctgg tgcccggcac catcgccttt accgacgcac      720

atatcgaggt ggacattacc tacgccgagt acttcgagat gagcgttcgg ctggcagaag      780

ctatgaagcg ctatgggctg aatacaaacc atcggatcgt ggtgtgcagc gagaatagct      840

tgcagttctt catgcccgtg ttgggtgccc tgttcatcgg tgtggctgtg gccccagcta      900

acgacatcta caacgagcgc gagctgctga acagcatggg catcagccag cccaccgtcg      960

tattcgtgag caagaaaggg ctgcaaaaga tcctcaacgt gcaaaagaag ctaccgatca     1020

tacaaaagat catcatcatg gatagcaaga ccgactacca gggcttccaa agcatgtaca     1080

ccttcgtgac ttcccatttg ccacccggct tcaacgagta cgacttcgtg cccgagagct     1140

tcgaccggga caaaaccatc gccctgatca tgaacagtag tggcagtacc ggattgccca     1200

agggcgtagc cctaccgcac cgcaccgctt gtgtccgatt cagtcatgcc cgcgacccca     1260

tcttcggcaa ccagatcatc cccgacaccg ctatcctcag cgtggtgcca tttcaccacg     1320

gcttcggcat gttcaccacg ctgggctact tgatctgcgg ctttcgggtc gtgctcatgt     1380

accgcttcga ggaggagcta ttcttgcgca gcttgcaaga ctataagatt caatctgccc     1440

tgctggtgcc cacactattt agcttcttcg ctaagagcac tctcatcgac aagtacgacc     1500

taagcaactt gcacgagatc gccagcggcg gggcgccgct cagcaaggag gtaggtgagg     1560

ccgtggccaa acgcttccac ctaccaggca tccgccaggg ctacggcctg acagaaacaa     1620

ccagcgccat tctgatcacc cccgaagggg acgacaagcc tggcgcagta ggcaaggtgg     1680

tgcccttctt cgaggctaag gtggtggact tggacaccgg taagacactg ggtgtgaacc     1740

agcgcggcga gctgtgcgtc cgtggcccca tgatcatgag cggctacgtt aacaaccccg     1800

aggctacaaa cgctctcatc gacaaggacg gctggctgca cagcggcgac atcgcctact     1860

gggacgagga cgagcacttc ttcatcgtgg accggctgaa gagcctgatc aaatacaagg     1920

gctaccaggt agccccagcc gaactggaga gcatcctgct gcaacacccc aacatcttcg     1980

acgccggggt cgccggcctg cccgacgacg atgccggcga gctgcccgcc gcagtcgtcg     2040

tgctggaaca cggtaaaacc atgaccgaga aggagatcgt ggactatgtg gccagccagg     2100

ttacaaccgc caagaagctg cgcggtggtg ttgtgttcgt ggacgaggtg cctaaaggac     2160

tgaccggcaa gttggacgcc cgcaagatcc gcgagattct cattaaggcc aagaagggcg     2220

gcaagatcgc cgtgtaa                                                    2237


<210>  21
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  L1 insert sequence

<400>  21

Met Ala Thr Thr Met Glu Gln Glu Thr Cys Ala His Ser Leu Thr Phe 
1               5                   10                  15      


Glu Glu Cys Pro Lys Cys Ser Ala Leu Gln Tyr Arg Asn Gly Phe Tyr 
            20                  25                  30          


Leu Leu Lys Tyr Asp Glu Glu Trp Tyr Pro Glu Glu Leu Leu Thr Asp 
        35                  40                  45              


Gly Glu Asp Asp Val Phe Asp Pro Glu Leu Asp Met Glu Val Val Phe 
    50                  55                  60                  


Glu Leu Gln 
65          


<210>  22
<211>  204
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  L1 insert sequence

<400>  22
atggccacaa ccatggaaca agagacttgc gcgcactctc tcacttttga ggaatgccca       60

aaatgctctg ctctacaata ccgtaatgga ttttacctgc taaagtatga tgaagaatgg      120

tacccagagg agttattgac tgatggagag gatgatgtct ttgatcccga attagacatg      180

gaagtcgttt tcgagttaca gtaa                                             204


<210>  23
<211>  564
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  IRES  insert sequence

<400>  23
cccccccccc taacgttact ggccgaagcc gcttggaata aggccggtgt gcgtttgtct       60

atatgttatt ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc      120

ctgtcttctt gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc      180

tgttgaatgt cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg      240

tagcgaccct ttgcaggcag cggaaccccc cacctggcga caggtgcctc tgcggccaaa      300

agccacgtgt ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt      360

ggatagttgt ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg      420

atgcccagaa ggtaccccat tgtatgggat ctgatctggg gcctcggtgc acatgcttta      480

catgtgttta gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt      540

tcctttgaaa aacacgatga taat                                             564


<210>  24
<211>  76
<212>  PRT
<213>  Cardiovirus Cardiovirus B

<400>  24

Met Ala Cys Lys His Gly Tyr Pro Asp Val Cys Pro Ile Cys Thr Ala 
1               5                   10                  15      


Val Asp Ala Thr Pro Gly Phe Glu Tyr Leu Leu Met Ala Asp Gly Glu 
            20                  25                  30          


Trp Tyr Pro Thr Asp Leu Leu Cys Val Asp Leu Asp Asp Asp Val Phe 
        35                  40                  45              


Trp Pro Ser Asp Thr Ser Asn Gln Ser Gln Thr Met Asp Trp Thr Asp 
    50                  55                  60                  


Val Pro Leu Ile Arg Asp Ile Val Met Glu Pro Gln 
65                  70                  75      


<210>  25
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  25
gcccgggatc caccggtcgc caccatggtg agcaagggcg aggagc                      46


<210>  26
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  26
agatggctgg caactagaag gcacagttac ttgtacagct cgtccatgcc gag              53


<210>  27
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  27
cactctcggc atggacgagc tgtacaagta actgtgcctt ctagttgcca gccatctgt        59


<210>  28
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  28
cagctcctcg cccttgctca ccatggtggc gaccggtgga tccc                        44


<210>  29
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  29
cggccagtaa cgttaggggg gggggattac ttgtacagct cgtccatgcc gag              53


<210>  30
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  30
cggtaccgcg ggcccgggat ccaccggtcg ccaccatggt gagcaagggc gaggagc          57


<210>  31
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  31
ctcggcatgg acgagctgta caagtaatcc ccccccccta acgttactgg                  50


<210>  32
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  32
acgggggagg ggcaaacaac agatggctgg caactagaag gcacagctgt aactcgaaaa       60

cgacttccat gtctaattcg g                                                 81


<210>  33
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  33
cgcgggcccg ggatccaccg gtcgccacca tgaacaccat caatattgcc aagaacgact       60

tttctgacat cg                                                           72


<210>  34
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  34
agatggctgg caactagaag gcacagttag ggtcaggcaa atgcgaaatc ggactccag        59


<210>  35
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  35
cctggagtcc gatttcgcat ttgcctgacc ctaactgtgc cttctagttg ccagccatct       60

gt                                                                      62


<210>  36
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  36
cgttcttggc aatattgatg gtgttcatgg tggcgaccgg tggatcccgg gcc              53


<210>  37
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  37
accttggccg actctggtaa tggtaatacg actcactata ggaaaaa                     47


<210>  38
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  38
agtcagtgag cgaggaagcc caaaaaaccc ctcaagaccc gttta                       45


<210>  39
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  39
aaacgggtct tgaggggttt tttgggcttc ctcgctcact gac                         43


<210>  40
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  40
tagtgagtcg tattaccatt accagagtcg gccaaggt                               38


<210>  41
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  41
gcccgggatc caccggtcgc cacctcgcca ccatgaggac tctgaacacc tctgccatgg       60


<210>  42
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  42
cttttcgaac tgcgggtggc tccagagcgg ccgcgttccc gtggttgggt gctgaccgtt       60

ttgtgtg                                                                 67


<210>  43
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  43
acgcggccgc tctggagcca cccgcagttc gaaaagtaaa gcggccgcga ctctagatca       60


<210>  44
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  44
gtgttcagag tcctcatggt ggcgaggtgg cgacc                                  35


<210>  45
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  45
atccaccggt cgccaccatg aggactctga acacctctgc catgg                       45


<210>  46
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  46
tgtggtatgg ctgattatga tttactgtaa ctcgaaaacg acttccatgt ctaattcggg       60


<210>  47
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  47
gttttcgagt tacagtaaat cataatcagc cataccacat ttgtagaggt tttacttgct       60


<210>  48
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  48
tggcagaggt gttcagagtc ctcatggtgg cgaccggtgg                             40


<210>  49
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  49
caccatcacc atcaccatgt tatggccaca accatggaac aagagactt                   49


<210>  50
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  50
tcttgatgag ctgttcttcc aggaggataa agttgttcat ggtggcgacc ggtggatccc       60


<210>  51
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  51
cgggcccggg atccaccggt cgccaccatg aacaacttta tcctcctgga agaacagctc       60


<210>  52
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  52
aagtctcttg ttccatggtt gtggccataa catggtgatg gtgatggtg                   49


<210>  53
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  53
ctctcggcat ggacgagctg tacaag                                            26


<210>  54
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  54
ttacttgtac agctcgtcca tgccgagag                                         29


<210>  55
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  55
tgcgcgcaag tctcttgttc catggttgtg gccatggtgg cgaccggtgg atccc            55


<210>  56
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  56
cccgaattag acatggaagt cgttttcgag ttacag                                 36


<210>  57
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  57
gggatccacc ggtcgccacc atggccacaa ccatggaaca agagacttg                   49


<210>  58
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  58
ctgtaactcg aaaacgactt ccatgtctaa ttcggg                                 36


<210>  59
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  59
tctcttgttc catggttgtg gccatggtgg cgaccggtgg                             40


<210>  60
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  60
acgtggtttt cctttgaaaa acacgatgat aaatgaggac tctgaacacc tctgccatgg       60


<210>  61
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  61
gcagaggtgt tcagagtcct catttatcat cgtgtttttc aaaggaaaac cacg             54


<210>  62
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  62
agtcgttttc gagttacagt aatccccccc ccctaacgtt actgg                       45


<210>  63
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  63
ccagtaacgt tagggggggg ggattactgt aactcgaaaa cgacttccat gt               52


<210>  64
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  64
ccaccggtcg ccaccatggc cacaaccatg gaacaagag                              39


<210>  65
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  65
gatggtgtcc cccgccacct ccgccacctc caagtcctga ttctgcaatt tcagccagtt       60


<210>  66
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  66
aattgcagaa tcaggacttg gaggtggcgg aggtggcggg ggacaccatc accatcacca       60

tgtttaatcc ccccccccta acgttactgg                                        90


<210>  67
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  67
ttataggcgg acagcagcag ggtcagcacc atggtggcga ggtggcgacc                  50


<210>  68
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  68
cggccgctcg attacaagga tgacgacgat aaggtttaaa gcggccgcga ctctagatca       60


<210>  69
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  69
taaaccttat cgtcgtcatc cttgtaatcg agcggccgcg ttgtagggcc catgggggcg       60


<210>  70
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  70
gcgggcccgg gatccaccgg tcgccacctc gccaccatgg tgctgaccct gctgctgtcc       60


<210>  71
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  71
ccctgtcttc atggggcgag tatatgaccc cagggccgga ggtggcggag gtggc            55


<210>  72
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  72
ggagggtcag cagggtcagc ctggaggcca tggtggcgac cggtggatcc                  50


<210>  73
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  73
cggtaccgcg ggcccgggat ccaccggtcg ccaccatggc ctccaggctg accctg           56


<210>  74
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  74
tggtgtcccc cgccacctcc gccacctccg gccctggggt catatactcg cc               52


<210>  75
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  75
aattgcagaa tcaggacttg gaggtggcgg aggtggcggg ggacacc                     47


<210>  76
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  76
cataatcagc cataccacat ttgtagaggt tttacttgc                              39


<210>  77
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  77
tacttgtaca gctcgtccat gccgagag                                          28


<210>  78
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  78
ctctcggcat ggacgagctg tacaagta                                          28


<210>  79
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  79
gcaagtaaaa cctctacaaa tgtggtatgg ctgattatg                              39


<210>  80
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  80
tcctctctgc ttctagaata aatcataatc agccatacca catttgtaga ggttttactt       60

gct                                                                     63


<210>  81
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  81
tgtcatgaat cagtaggtcc gcaaagtaac cagcgtagtg cttgtacagc tcgtccatgc       60

cgagag                                                                  66


<210>  82
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  82
actttgcgga cctactgatt catgacattg agacaaatcc agggatgaac tttctacgta       60

agatagtgaa aaatt                                                        75


<210>  83
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  83
acctctacaa atgtggtatg gctgattatg atttattcta gaagcagaga ggaatctttg       60


<210>  84
<211>  85
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  84
gctggttact ttgcggacct actgattcat gacattgaga caaatccagg gggattcgga       60

caccaaaaca aagcggtgta cactg                                             85


<210>  85
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  85
aaacctctac aaatgtggta tggctgatta tgatttgttc catggcttct tcttcgtagg       60

catacaagtc                                                              70


<210>  86
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  86
tgtctcaatg tcatgaatca gtaggtccgc aaagtaacca gcgtagtgct tgtacagctc       60

gtccatgccg agagtgatcc c                                                 81


<210>  87
<211>  80
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  87
gagacttgta tgcctacgaa gaagaagcca tggaacaaat cataatcagc cataccacat       60

ttgtagaggt tttacttgct                                                   80


<210>  88
<211>  73
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  88
catggcagag gtgttcagag tcctcatggt ggcgaccggt ggattcacga cacctgaaat       60

ggaagaaaaa aac                                                          73


<210>  89
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  89
attaccgcca tgcattagtt attaggctcc ggtgcccgtc agtgggcaga gcg              53


<210>  90
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  90
agtttttttc ttccatttca ggtgtcgtga atccaccggt cgccaccatg aggactctga       60

acacctc                                                                 67


<210>  91
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  91
gtgcgctctg cccactgacg ggcaccggag cctaataact aatgcatggc ggtaat           56


<210>  92
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  92
gaggccgagg ccgcctcggc ctctgagcta atccaccggt cgccaccatg aggactctga       60

acacctc                                                                 67


<210>  93
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  93
ataaccgtat taccgccatg cattagttat taggtgtgga aagtccccag gctccccagc       60

aggcaga                                                                 67


<210>  94
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  94
ttcagagtcc tcatggtggc gaccggtgga ttagctcaga ggccgaggcg gcctcggcct       60

ct                                                                      62


<210>  95
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  95
tctgcctgct ggggagcctg gggactttcc acacctaata actaatgcat ggcggtaata       60

cggtta                                                                  66


<210>  96
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  96
ggaggtggcg gaggtggcgg gggacaccat caccatca                               38


<210>  97
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  97
agacaacgct ggccttttcc agaggcgacc tctgcatggt ggcgaccggt ggatcccggg       60

cccg                                                                    64


<210>  98
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  98
cgggcccggg atccaccggt cgccaccatg cagaggtcgc ctctggaaaa ggccagcgtt       60

gtctc                                                                   65


<210>  99
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  primer

<400>  99
ccccgccacc tccgccacct ccaagccttg tatcttgcac ctcttcttct gtctcc           56


<210>  100
<211>  7808
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  100
cgcgatgtac gggccagata tacgcgttga cattgattat tgactagtta ttaatagtaa       60

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      120

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      180

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      240

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      300

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      360

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt      420

tggcagtaca tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac      480

cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt      540

cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat      600

ataagcagag ctggtttagt gaaccgtcag atccgctagc gctaccggac tcagatctcg      660

agctcaagct tcgaattctg cagtcgacgg taccgcgggc ccgggatcca ccggtcgcca      720

cgatgaagtg ggtgaccttc atcagcctgc tgttcctgtt ttcttccgcc tacagcgaag      780

tgcagctggt tgaaagcgga ggcggactgg tccagccagg cagaagcctg agactgtctt      840

gtgccgcctc tggcttcacc tttgacgact acgccatgca ctgggtgcgg caggcccctg      900

gcaagggact cgagtgggtc agcgccatca cctggaatag cggccacatc gactacgcag      960

atagcgttga aggcagattc accatctcca gggacaacgc caagaattct ctgtacctgc     1020

agatgaacag cctgcgggcc gaggataccg ctgtgtacta ctgcgccaaa gtgtcctacc     1080

tgagcaccgc cagctccctg gactactggg gccagggcac cctggtgaca gtgagctctg     1140

ctagcacaaa aggacctagc gtgtttcccc tggcccctag cagcaaaagc accagcggcg     1200

gaaccgccgc tctgggttgt ctggtgaagg actatttccc tgaacctgtg accgtgtcct     1260

ggaactctgg cgccctgact agcggcgtgc ataccttccc tgccgtgctg caaagctctg     1320

gcctgtatag cctttcttct gtggtgaccg tgcctagcag ctctctgggc acacagacat     1380

acatctgcaa tgtgaaccac aagccctcca acaccaaggt ggacaaaaag gtggaaccca     1440

agagctgcga caagacccac acctgtcctc cgtgccccgc tcctgagctg ctgggcggcc     1500

cttctgtgtt cctgttcccc cccaaaccta aagacacact gatgatcagc cggacccctg     1560

aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc cgaggtgaag ttcaactggt     1620

acgtggacgg cgtggaggtc cacaacgcca agaccaaacc tagagaggaa caatacaaca     1680

gcacatatag agtggtgtct gtgctgacag tgctccacca ggactggctg aacggaaagg     1740

aatacaagtg caaggtgtcc aacaaggccc tccctgctcc aatcgagaag accattagca     1800

aggccaaggg ccaacctaga gagccccagg tctacaccct gccaccaagt agagatgagc     1860

tgaccaagaa ccaggtgagc ctaacatgcc tggtgaaggg cttttacccc agcgacatcg     1920

ccgtggaatg ggagagcaac ggccagcctg agaacaacta caagacaaca cctcctgttc     1980

tggattctga tggcagcttc ttcctgtaca gcaagctgac agtggataag agccggtggc     2040

agcagggcaa cgtgttcagc tgctccgtta tgcacgaggc cctgcataat cactacaccc     2100

agaagagcct gtctctgagc cctggcaagg aagtgcagct ggttgaaagc ggaggcggac     2160

tggtccagcc aggcagaagc ctgagactgt cttgtgccgc ctctggcttc acctttgacg     2220

actacgccat gcactgggtg cggcaggccc ctggcaaggg actcgagtgg gtcagcgcca     2280

tcacctggaa tagcggccac atcgactacg cagatagcgt tgaaggcaga ttcaccatct     2340

ccagggacaa cgccaagaat tctctgtacc tgcagatgaa cagcctgcgg gccgaggata     2400

ccgctgtgta ctactgcgcc aaagtgtcct acctgagcac cgccagctcc ctggactact     2460

ggggccaggg caccctggtg acagtgagct ctgctagcac aaaaggacct agcgtgtttc     2520

ccctggcccc tagcagcaaa agcaccagcg gcggaaccgc cgctctgggt tgtctggtga     2580

aggactattt ccctgaacct gtgaccgtgt cctggaactc tggcgccctg actagcggcg     2640

tgcatacctt ccctgccgtg ctgcaaagct ctggcctgta tagcctttct tctgtggtga     2700

ccgtgcctag cagctctctg ggcacacaga catacatctg caatgtgaac cacaagccct     2760

ccaacaccaa ggtggacaaa aaggtggaac ccaagagctg cgacaagacc cacacctgtc     2820

ctccgtgccc cgctcctgag ctgctgggcg gcccttctgt gttcctgttc ccccccaaac     2880

ctaaagacac actgatgatc agccggaccc ctgaggtgac ctgcgtggtg gtggacgtga     2940

gccacgagga ccccgaggtg aagttcaact ggtacgtgga cggcgtggag gtccacaacg     3000

ccaagaccaa acctagagag gaacaataca acagcacata tagagtggtg tctgtgctga     3060

cagtgctcca ccaggactgg ctgaacggaa aggaatacaa gtgcaaggtg tccaacaagg     3120

ccctccctgc tccaatcgag aagaccatta gcaaggccaa gggccaacct agagagcccc     3180

aggtctacac cctgccacca agtagagatg agctgaccaa gaaccaggtg agcctaacat     3240

gcctggtgaa gggcttttac cccagcgaca tcgccgtgga atgggagagc aacggccagc     3300

ctgagaacaa ctacaagaca acacctcctg ttctggattc tgatggcagc ttcttcctgt     3360

acagcaagct gacagtggat aagagccggt ggcagcaggg caacgtgttc agctgctccg     3420

ttatgcacga ggccctgcat aatcactaca cccagaagag cctgtctctg agccctggca     3480

agcaagcgaa aacggcgcgg aagcggagct actaacttca gcctgctgaa gcaggctgga     3540

gatgtggagg agaaccctgg acctgatatc cagatgaccc agtctccatc tagcctgagc     3600

gccagcgtgg gagatagagt gaccatcacc tgtagagcct ctcaaggcat ccggaactac     3660

ctggcctggt atcagcagaa acctggcaag gctcctaagc tgctgatcta cgccgcttcc     3720

accctgcaga gcggcgttcc ttctagattc agcggcagcg gctccggaac agacttcacc     3780

ctgacaatta gctccctgca acctgaagat gtggctacat actactgcca gagatacaat     3840

cgggcccctt acacctttgg acagggcacc aaggtggaaa tcaagcggac cgtggccgcc     3900

ccatctgtgt tcatcttccc ccccagcgac gagcagctga aaagcggcac agccagcgtg     3960

gtgtgcctgc tgaacaactt ctaccccagg gaagccaagg tgcagtggaa ggtggacaat     4020

gccctgcaga gcggcaacag ccaggagagc gtgaccgagc aggacagcaa ggacagcacc     4080

tacagcctga gcagcaccct cacactgtct aaagccgact acgagaagca caaggtctac     4140

gcctgcgagg tgacccacca gggcctgtcc tcccctgtga caaagagctt taacagaggc     4200

gagtgctaag atatccagat gacccagtct ccatctagcc tgagcgccag cgtgggagat     4260

agagtgacca tcacctgtag agcctctcaa ggcatccgga actacctggc ctggtatcag     4320

cagaaacctg gcaaggctcc taagctgctg atctacgccg cttccaccct gcagagcggc     4380

gttccttcta gattcagcgg cagcggctcc ggaacagact tcaccctgac aattagctcc     4440

ctgcaacctg aagatgtggc tacatactac tgccagagat acaatcgggc cccttacacc     4500

tttggacagg gcaccaaggt ggaaatcaag cggaccgtgg ccgccccatc tgtgttcatc     4560

ttccccccca gcgacgagca gctgaaaagc ggcacagcca gcgtggtgtg cctgctgaac     4620

aacttctacc ccagggaagc caaggtgcag tggaaggtgg acaatgccct gcagagcggc     4680

aacagccagg agagcgtgac cgagcaggac agcaaggaca gcacctacag cctgagcagc     4740

accctcacac tgtctaaagc cgactacgag aagcacaagg tctacgcctg cgaggtgacc     4800

caccagggcc tgtcctcccc tgtgacaaag agctttaaca gaggcgagtg ctaacccccc     4860

cccctaacgt tactggccga agccgcttgg aataaggccg gtgtgcgttt gtctatatgt     4920

tattttccac catattgccg tcttttggca atgtgagggc ccggaaacct ggccctgtct     4980

tcttgacgag cattcctagg ggtctttccc ctctcgccaa aggaatgcaa ggtctgttga     5040

atgtcgtgaa ggaagcagtt cctctggaag cttcttgaag acaaacaacg tctgtagcga     5100

ccctttgcag gcagcggaac cccccacctg gcgacaggtg cctctgcggc caaaagccac     5160

gtgtataaga tacacctgca aaggcggcac aaccccagtg ccacgttgtg agttggatag     5220

ttgtggaaag agtcaaatgg ctctcctcaa gcgtattcaa caaggggctg aaggatgccc     5280

agaaggtacc ccattgtatg ggatctgatc tggggcctcg gtgcacatgc tttacatgtg     5340

tttagtcgag gttaaaaaaa cgtctaggcc ccccgaacca cggggacgtg gttttccttt     5400

gaaaaacacg atgataatat ggccacaacc atggaacaag agacttgcgc gcactctctc     5460

acttttgagg aatgcccaaa atgctctgct ctacaatacc gtaatggatt ttacctgcta     5520

aagtatgatg aagaatggta cccagaggag ttattgactg atggagagga tgatgtcttt     5580

gatcccgaat tagacatgga agtcgttttc gagttacagt aaatcataat cagccatacc     5640

acatttgtag aggttttact tgctttaaaa aacctcccac acctccccct gaacctgaaa     5700

cataaaatga atgcaattgt tgttgttaac ttgtttattg cagcttataa tggttacaaa     5760

taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca ttctagttgt     5820

ggtttgtcca aactcatcaa tgtatcttaa ggcgtcttct actgggcggt tttatggaca     5880

gcaagcgaac cggaattgcc agctggggcg ccctctggta aggttgggaa gccctgcaaa     5940

gtaaactgga tggctttctt gccgccaagg atctgatggc gcaggggatc aagctctgat     6000

caagagacag gatgaggatc gtttcgcatg attgaacaag atggattgca cgcaggttct     6060

ccggccgctt gggtggagag gctattcggc tatgactggg cacaacagac aatcggctgc     6120

tctgatgccg ccgtgttccg gctgtcagcg caggggcgcc cggttctttt tgtcaagacc     6180

gacctgtccg gtgccctgaa tgaactgcaa gacgaggcag cgcggctatc gtggctggcc     6240

acgacgggcg ttccttgcgc agctgtgctc gacgttgtca ctgaagcggg aagggactgg     6300

ctgctattgg gcgaagtgcc ggggcaggat ctcctgtcat ctcaccttgc tcctgccgag     6360

aaagtatcca tcatggctga tgcaatgcgg cggctgcata cgcttgatcc ggctacctgc     6420

ccattcgacc accaagcgaa acatcgcatc gagcgagcac gtactcggat ggaagccggt     6480

cttgtcgatc aggatgatct ggacgaagag catcaggggc tcgcgccagc cgaactgttc     6540

gccaggctca aggcgagcat gcccgacggc gaggatctcg tcgtgaccca tggcgatgcc     6600

tgcttgccga atatcatggt ggaaaatggc cgcttttctg gattcatcga ctgtggccgg     6660

ctgggtgtgg cggaccgcta tcaggacata gcgttggcta cccgtgatat tgctgaagag     6720

cttggcggcg aatgggctga ccgcttcctc gtgctttacg gtatcgccgc tcccgattcg     6780

cagcgcatcg ccttctatcg ccttcttgac gagttcttct gaattattaa cgcttacaat     6840

ttcctgatgc ggtattttct ccttacgcat ctgtgcggta tttcacaccg catacaggtg     6900

gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt atttttctaa atacattcaa     6960

atatgtatcc gctcatgaga caataaccct gataaatgct tcaataatag cacgtgctaa     7020

aacttcattt ttaatttaaa aggatctagg tgaagatcct ttttgataat ctcatgacca     7080

aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag     7140

gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac     7200

cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa     7260

ctggcttcag cagagcgcag ataccaaata ctgtccttct agtgtagccg tagttaggcc     7320

accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag     7380

tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac     7440

cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc     7500

gaacgaccta caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc     7560

ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca     7620

cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc     7680

tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg     7740

ccagcaacgc ggccttttta cggttcctgg gcttttgctg gccttttgct cacatgttct     7800

tgactctt                                                              7808


<210>  101
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  101
cgcgatgtac gggccagata tacgcgtt                                          28


<210>  102
<211>  380
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CMV enhancer

<400>  102
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggactatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg                                                  380


<210>  103
<211>  204
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CMV promoter

<400>  103
gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt       60

ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac      120

tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg      180

tgggaggtct atataagcag agct                                             204


<210>  104
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  104
ggtttagtga accgtcagat ccgctagcgc taccggactc agatctcgag ctcaagcttc       60

gaattctgca gtcgacggta ccgcgggccc gggatccacc ggtcgccacg                 110


<210>  105
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Albumin signal peptide (codon optimized)

<400>  105
atgaagtggg tgaccttcat cagcctgctg ttcctgtttt cttccgccta cagc             54


<210>  106
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Adalimumab Heavy Chain (variable region)

<400>  106
gaagtgcagc tggttgaaag cggaggcgga ctggtccagc caggcagaag cctgagactg       60

tcttgtgccg cctctggctt cacctttgac gactacgcca tgcactgggt gcggcaggcc      120

cctggcaagg gactcgagtg ggtcagcgcc atcacctgga atagcggcca catcgactac      180

gcagatagcg ttgaaggcag attcaccatc tccagggaca acgccaagaa ttctctgtac      240

ctgcagatga acagcctgcg ggccgaggat accgctgtgt actactgcgc caaagtgtcc      300

tacctgagca ccgccagctc cctggactac tggggccagg gcaccctggt gacagtgagc      360

tct                                                                    363


<210>  107
<211>  990
<212>  DNA
<213>  Homo sapiens

<400>  107
gctagcacaa aaggacctag cgtgtttccc ctggccccta gcagcaaaag caccagcggc       60

ggaaccgccg ctctgggttg tctggtgaag gactatttcc ctgaacctgt gaccgtgtcc      120

tggaactctg gcgccctgac tagcggcgtg cataccttcc ctgccgtgct gcaaagctct      180

ggcctgtata gcctttcttc tgtggtgacc gtgcctagca gctctctggg cacacagaca      240

tacatctgca atgtgaacca caagccctcc aacaccaagg tggacaaaaa ggtggaaccc      300

aagagctgcg acaagaccca cacctgtcct ccgtgccccg ctcctgagct gctgggcggc      360

ccttctgtgt tcctgttccc ccccaaacct aaagacacac tgatgatcag ccggacccct      420

gaggtgacct gcgtggtggt ggacgtgagc cacgaggacc ccgaggtgaa gttcaactgg      480

tacgtggacg gcgtggaggt ccacaacgcc aagaccaaac ctagagagga acaatacaac      540

agcacatata gagtggtgtc tgtgctgaca gtgctccacc aggactggct gaacggaaag      600

gaatacaagt gcaaggtgtc caacaaggcc ctccctgctc caatcgagaa gaccattagc      660

aaggccaagg gccaacctag agagccccag gtctacaccc tgccaccaag tagagatgag      720

ctgaccaaga accaggtgag cctaacatgc ctggtgaagg gcttttaccc cagcgacatc      780

gccgtggaat gggagagcaa cggccagcct gagaacaact acaagacaac acctcctgtt      840

ctggattctg atggcagctt cttcctgtac agcaagctga cagtggataa gagccggtgg      900

cagcagggca acgtgttcag ctgctccgtt atgcacgagg ccctgcataa tcactacacc      960

cagaagagcc tgtctctgag ccctggcaag                                       990


<210>  108
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Furin cleavage site

<400>  108
caagcgaaaa cggcgc                                                       16


<210>  109
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  GSG linker

<400>  109
ggaagcgga                                                                9


<210>  110
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  P2A self-cleaving peptide

<400>  110
gctactaact tcagcctgct gaagcaggct ggagatgtgg aggagaaccc tggacct          57


<210>  111
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Adalimumab Light Chain (variable region)

<400>  111
gatatccaga tgacccagtc tccatctagc ctgagcgcca gcgtgggaga tagagtgacc       60

atcacctgta gagcctctca aggcatccgg aactacctgg cctggtatca gcagaaacct      120

ggcaaggctc ctaagctgct gatctacgcc gcttccaccc tgcagagcgg cgttccttct      180

agattcagcg gcagcggctc cggaacagac ttcaccctga caattagctc cctgcaacct      240

gaagatgtgg ctacatacta ctgccagaga tacaatcggg ccccttacac ctttggacag      300

ggcaccaagg tggaaatcaa g                                                321


<210>  112
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  112
cggaccgtgg ccgccccatc tgtgttcatc ttccccccca gcgacgagca gctgaaaagc       60

ggcacagcca gcgtggtgtg cctgctgaac aacttctacc ccagggaagc caaggtgcag      120

tggaaggtgg acaatgccct gcagagcggc aacagccagg agagcgtgac cgagcaggac      180

agcaaggaca gcacctacag cctgagcagc accctcacac tgtctaaagc cgactacgag      240

aagcacaagg tctacgcctg cgaggtgacc caccagggcc tgtcctcccc tgtgacaaag      300

agctttaaca gaggcgagtg ctaa                                             324


<210>  113
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  113
cccccccccc ta                                                           12


<210>  114
<211>  552
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  IRES

<400>  114
acgttactgg ccgaagccgc ttggaataag gccggtgtgc gtttgtctat atgttatttt       60

ccaccatatt gccgtctttt ggcaatgtga gggcccggaa acctggccct gtcttcttga      120

cgagcattcc taggggtctt tcccctctcg ccaaaggaat gcaaggtctg ttgaatgtcg      180

tgaaggaagc agttcctctg gaagcttctt gaagacaaac aacgtctgta gcgacccttt      240

gcaggcagcg gaacccccca cctggcgaca ggtgcctctg cggccaaaag ccacgtgtat      300

aagatacacc tgcaaaggcg gcacaacccc agtgccacgt tgtgagttgg atagttgtgg      360

aaagagtcaa atggctctcc tcaagcgtat tcaacaaggg gctgaaggat gcccagaagg      420

taccccattg tatgggatct gatctggggc ctcggtgcac atgctttaca tgtgtttagt      480

cgaggttaaa aaaacgtcta ggccccccga accacgggga cgtggttttc ctttgaaaaa      540

cacgatgata at                                                          552


<210>  115
<211>  204
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Enhancer peptide

<400>  115
atggccacaa ccatggaaca agagacttgc gcgcactctc tcacttttga ggaatgccca       60

aaatgctctg ctctacaata ccgtaatgga ttttacctgc taaagtatga tgaagaatgg      120

tacccagagg agttattgac tgatggagag gatgatgtct ttgatcccga attagacatg      180

gaagtcgttt tcgagttaca gtaa                                             204


<210>  116
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  116
atcataatca gccataccac atttgtagag gttttacttg ctttaaaaaa cctcccacac       60

ctccccctga acctgaaaca taaaatgaat gcaattgttg ttgtt                      105


<210>  117
<211>  122
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  SV40 poly(A) signal

<400>  117
aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca       60

aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct      120

ta                                                                     122


<210>  118
<211>  178
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker

<400>  118
aggcgtcttc tactgggcgg ttttatggac agcaagcgaa ccggaattgc cagctggggc       60

gccctctggt aaggttggga agccctgcaa agtaaactgg atggctttct tgccgccaag      120

gatctgatgg cgcaggggat caagctctga tcaagagaca ggatgaggat cgtttcgc        178


<210>  119
<211>  795
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Neomycin/Kanamycin resistance gene

<400>  119
atgattgaac aagatggatt gcacgcaggt tctccggccg cttgggtgga gaggctattc       60

ggctatgact gggcacaaca gacaatcggc tgctctgatg ccgccgtgtt ccggctgtca      120

gcgcaggggc gcccggttct ttttgtcaag accgacctgt ccggtgccct gaatgaactg      180

caagacgagg cagcgcggct atcgtggctg gccacgacgg gcgttccttg cgcagctgtg      240

ctcgacgttg tcactgaagc gggaagggac tggctgctat tgggcgaagt gccggggcag      300

gatctcctgt catctcacct tgctcctgcc gagaaagtat ccatcatggc tgatgcaatg      360

cggcggctgc atacgcttga tccggctacc tgcccattcg accaccaagc gaaacatcgc      420

atcgagcgag cacgtactcg gatggaagcc ggtcttgtcg atcaggatga tctggacgaa      480

gagcatcagg ggctcgcgcc agccgaactg ttcgccaggc tcaaggcgag catgcccgac      540

ggcgaggatc tcgtcgtgac ccatggcgat gcctgcttgc cgaatatcat ggtggaaaat      600

ggccgctttt ctggattcat cgactgtggc cggctgggtg tggcggaccg ctatcaggac      660

atagcgttgg ctacccgtga tattgctgaa gagcttggcg gcgaatgggc tgaccgcttc      720

ctcgtgcttt acggtatcgc cgctcccgat tcgcagcgca tcgccttcta tcgccttctt      780

gacgagttct tctga                                                       795


<210>  120
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  120
attattaacg cttacaattt cctgatgcgg tattttctcc ttacgcatct gtgcggtatt       60

tcacaccgca tacaggtggc acttttcggg gaaatgtgcg cggaacccct atttgtttat      120

ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga taaatgcttc      180

aataatagca cgtgctaaaa cttcattttt aatttaaaag gatctaggtg aagatccttt      240

ttgataatct catgaccaaa atcccttaac gtgagttttc gttccactga gcgtcagacc      300

ccgtagaaaa gatcaaagga tcttc                                            325


<210>  121
<211>  589
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Origin of replication

<400>  121
ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc       60

agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt      120

cagcagagcg cagataccaa atactgtcct tctagtgtag ccgtagttag gccaccactt      180

caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc      240

tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa      300

ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac      360

ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg      420

gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga      480

gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact      540

tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaa                  589


<210>  122
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  122
aacgccagca acgcggcctt tttacggttc ctgggctttt gctggccttt tgctcacatg       60

ttcttgactc tt                                                           72


<210>  123
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Albumin signal peptide

<400>  123

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  124
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Adalimumab heavy chain (variable region)

<400>  124

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  125
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  125

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  126
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Furin cleavage site

<400>  126

Arg Lys Arg Arg 
1               


<210>  127
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Linker

<400>  127

Gly Ser Gly 
1           


<210>  128
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  P2A self-cleaving peptide

<400>  128

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  129
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Adalimumab Light Chain (variable region)

<400>  129

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  130
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  130

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  131
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Enhancer peptide

<400>  131

Met Ala Thr Thr Met Glu Gln Glu Thr Cys Ala His Ser Leu Thr Phe 
1               5                   10                  15      


Glu Glu Cys Pro Lys Cys Ser Ala Leu Gln Tyr Arg Asn Gly Phe Tyr 
            20                  25                  30          


Leu Leu Lys Tyr Asp Glu Glu Trp Tyr Pro Glu Glu Leu Leu Thr Asp 
        35                  40                  45              


Gly Glu Asp Asp Val Phe Asp Pro Glu Leu Asp Met Glu Val Val Phe 
    50                  55                  60                  


Glu Leu Gln 
65          


<210>  132
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Albumin complete heavy chain

<400>  132

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  133
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Albumin complete light chain

<400>  133

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  134
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Albumin Heavy Chain complete

<400>  134
gaagtgcagc tggttgaaag cggaggcgga ctggtccagc caggcagaag cctgagactg       60

tcttgtgccg cctctggctt cacctttgac gactacgcca tgcactgggt gcggcaggcc      120

cctggcaagg gactcgagtg ggtcagcgcc atcacctgga atagcggcca catcgactac      180

gcagatagcg ttgaaggcag attcaccatc tccagggaca acgccaagaa ttctctgtac      240

ctgcagatga acagcctgcg ggccgaggat accgctgtgt actactgcgc caaagtgtcc      300

tacctgagca ccgccagctc cctggactac tggggccagg gcaccctggt gacagtgagc      360

tctgctagca caaaaggacc tagcgtgttt cccctggccc ctagcagcaa aagcaccagc      420

ggcggaaccg ccgctctggg ttgtctggtg aaggactatt tccctgaacc tgtgaccgtg      480

tcctggaact ctggcgccct gactagcggc gtgcatacct tccctgccgt gctgcaaagc      540

tctggcctgt atagcctttc ttctgtggtg accgtgccta gcagctctct gggcacacag      600

acatacatct gcaatgtgaa ccacaagccc tccaacacca aggtggacaa aaaggtggaa      660

cccaagagct gcgacaagac ccacacctgt cctccgtgcc ccgctcctga gctgctgggc      720

ggcccttctg tgttcctgtt cccccccaaa cctaaagaca cactgatgat cagccggacc      780

cctgaggtga cctgcgtggt ggtggacgtg agccacgagg accccgaggt gaagttcaac      840

tggtacgtgg acggcgtgga ggtccacaac gccaagacca aacctagaga ggaacaatac      900

aacagcacat atagagtggt gtctgtgctg acagtgctcc accaggactg gctgaacgga      960

aaggaataca agtgcaaggt gtccaacaag gccctccctg ctccaatcga gaagaccatt     1020

agcaaggcca agggccaacc tagagagccc caggtctaca ccctgccacc aagtagagat     1080

gagctgacca agaaccaggt gagcctaaca tgcctggtga agggctttta ccccagcgac     1140

atcgccgtgg aatgggagag caacggccag cctgagaaca actacaagac aacacctcct     1200

gttctggatt ctgatggcag cttcttcctg tacagcaagc tgacagtgga taagagccgg     1260

tggcagcagg gcaacgtgtt cagctgctcc gttatgcacg aggccctgca taatcactac     1320

acccagaaga gcctgtctct gagccctggc aag                                  1353


<210>  135
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Albumin Light Chain complete

<400>  135
gatatccaga tgacccagtc tccatctagc ctgagcgcca gcgtgggaga tagagtgacc       60

atcacctgta gagcctctca aggcatccgg aactacctgg cctggtatca gcagaaacct      120

ggcaaggctc ctaagctgct gatctacgcc gcttccaccc tgcagagcgg cgttccttct      180

agattcagcg gcagcggctc cggaacagac ttcaccctga caattagctc cctgcaacct      240

gaagatgtgg ctacatacta ctgccagaga tacaatcggg ccccttacac ctttggacag      300

ggcaccaagg tggaaatcaa gcggaccgtg gccgccccat ctgtgttcat cttccccccc      360

agcgacgagc agctgaaaag cggcacagcc agcgtggtgt gcctgctgaa caacttctac      420

cccagggaag ccaaggtgca gtggaaggtg gacaatgccc tgcagagcgg caacagccag      480

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctcaca      540

ctgtctaaag ccgactacga gaagcacaag gtctacgcct gcgaggtgac ccaccagggc      600

ctgtcctccc ctgtgacaaa gagctttaac agaggcgagt gctaa                      645


<210>  136
<211>  5096
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  synthetic construct

<400>  136
cgcgatgtac gggccagata tacgcgttga cattgattat tgactagtta ttaatagtaa       60

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      120

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      180

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      240

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      300

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      360

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt      420

tggcagtaca tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac      480

cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt      540

cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat      600

ataagcagag ctggtttagt gaaccgtcag atccgctagc gctaccggac tcagatctcg      660

agctcaagct tcgaattctg cagtcgacgg taccgcgggc ccgggatcca ccggtcgcca      720

cgatgaagtg ggtgaccttc atcagcctgc tgttcctgtt ttcttccgcc tacagcgaag      780

tgcagctggt tgaaagcgga ggcggactgg tccagccagg cagaagcctg agactgtctt      840

gtgccgcctc tggcttcacc tttgacgact acgccatgca ctgggtgcgg caggcccctg      900

gcaagggact cgagtgggtc agcgccatca cctggaatag cggccacatc gactacgcag      960

atagcgttga aggcagattc accatctcca gggacaacgc caagaattct ctgtacctgc     1020

agatgaacag cctgcgggcc gaggataccg ctgtgtacta ctgcgccaaa gtgtcctacc     1080

tgagcaccgc cagctccctg gactactggg gccagggcac cctggtgaca gtgagctctg     1140

ctagcacaaa aggacctagc gtgtttcccc tggcccctag cagcaaaagc accagcggcg     1200

gaaccgccgc tctgggttgt ctggtgaagg actatttccc tgaacctgtg accgtgtcct     1260

ggaactctgg cgccctgact agcggcgtgc ataccttccc tgccgtgctg caaagctctg     1320

gcctgtatag cctttcttct gtggtgaccg tgcctagcag ctctctgggc acacagacat     1380

acatctgcaa tgtgaaccac aagccctcca acaccaaggt ggacaaaaag gtggaaccca     1440

agagctgcga caagacccac acctgtcctc cgtgccccgc tcctgagctg ctgggcggcc     1500

cttctgtgtt cctgttcccc cccaaaccta aagacacact gatgatcagc cggacccctg     1560

aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc cgaggtgaag ttcaactggt     1620

acgtggacgg cgtggaggtc cacaacgcca agaccaaacc tagagaggaa caatacaaca     1680

gcacatatag agtggtgtct gtgctgacag tgctccacca ggactggctg aacggaaagg     1740

aatacaagtg caaggtgtcc aacaaggccc tccctgctcc aatcgagaag accattagca     1800

aggccaaggg ccaacctaga gagccccagg tctacaccct gccaccaagt agagatgagc     1860

tgaccaagaa ccaggtgagc ctaacatgcc tggtgaaggg cttttacccc agcgacatcg     1920

ccgtggaatg ggagagcaac ggccagcctg agaacaacta caagacaaca cctcctgttc     1980

tggattctga tggcagcttc ttcctgtaca gcaagctgac agtggataag agccggtggc     2040

agcagggcaa cgtgttcagc tgctccgtta tgcacgaggc cctgcataat cactacaccc     2100

agaagagcct gtctctgagc cctggcaagc aagcgaaaac ggcgcggaag cggagctact     2160

aacttcagcc tgctgaagca ggctggagat gtggaggaga accctggacc tatgaagtgg     2220

gtgaccttca tcagcctgct gttcctgttt tcttccgcct acagcgatat ccagatgacc     2280

cagtctccat ctagcctgag cgccagcgtg ggagatagag tgaccatcac ctgtagagcc     2340

tctcaaggca tccggaacta cctggcctgg tatcagcaga aacctggcaa ggctcctaag     2400

ctgctgatct acgccgcttc caccctgcag agcggcgttc cttctagatt cagcggcagc     2460

ggctccggaa cagacttcac cctgacaatt agctccctgc aacctgaaga tgtggctaca     2520

tactactgcc agagatacaa tcgggcccct tacacctttg gacagggcac caaggtggaa     2580

atcaagcgga ccgtggccgc cccatctgtg ttcatcttcc cccccagcga cgagcagctg     2640

aaaagcggca cagccagcgt ggtgtgcctg ctgaacaact tctaccccag ggaagccaag     2700

gtgcagtgga aggtggacaa tgccctgcag agcggcaaca gccaggagag cgtgaccgag     2760

caggacagca aggacagcac ctacagcctg agcagcaccc tcacactgtc taaagccgac     2820

tacgagaagc acaaggtcta cgcctgcgag gtgacccacc agggcctgtc ctcccctgtg     2880

acaaagagct ttaacagagg cgagtgctaa atcataatca gccataccac atttgtagag     2940

gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca taaaatgaat     3000

gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata aagcaatagc     3060

atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa     3120

ctcatcaatg tatcttaagg cgtcttctac tgggcggttt tatggacagc aagcgaaccg     3180

gaattgccag ctggggcgcc ctctggtaag gttgggaagc cctgcaaagt aaactggatg     3240

gctttcttgc cgccaaggat ctgatggcgc aggggatcaa gctctgatca agagacagga     3300

tgaggatcgt ttcgcatgat tgaacaagat ggattgcacg caggttctcc ggccgcttgg     3360

gtggagaggc tattcggcta tgactgggca caacagacaa tcggctgctc tgatgccgcc     3420

gtgttccggc tgtcagcgca ggggcgcccg gttctttttg tcaagaccga cctgtccggt     3480

gccctgaatg aactgcaaga cgaggcagcg cggctatcgt ggctggccac gacgggcgtt     3540

ccttgcgcag ctgtgctcga cgttgtcact gaagcgggaa gggactggct gctattgggc     3600

gaagtgccgg ggcaggatct cctgtcatct caccttgctc ctgccgagaa agtatccatc     3660

atggctgatg caatgcggcg gctgcatacg cttgatccgg ctacctgccc attcgaccac     3720

caagcgaaac atcgcatcga gcgagcacgt actcggatgg aagccggtct tgtcgatcag     3780

gatgatctgg acgaagagca tcaggggctc gcgccagccg aactgttcgc caggctcaag     3840

gcgagcatgc ccgacggcga ggatctcgtc gtgacccatg gcgatgcctg cttgccgaat     3900

atcatggtgg aaaatggccg cttttctgga ttcatcgact gtggccggct gggtgtggcg     3960

gaccgctatc aggacatagc gttggctacc cgtgatattg ctgaagagct tggcggcgaa     4020

tgggctgacc gcttcctcgt gctttacggt atcgccgctc ccgattcgca gcgcatcgcc     4080

ttctatcgcc ttcttgacga gttcttctga attattaacg cttacaattt cctgatgcgg     4140

tattttctcc ttacgcatct gtgcggtatt tcacaccgca tacaggtggc acttttcggg     4200

gaaatgtgcg cggaacccct atttgtttat ttttctaaat acattcaaat atgtatccgc     4260

tcatgagaca ataaccctga taaatgcttc aataatagca cgtgctaaaa cttcattttt     4320

aatttaaaag gatctaggtg aagatccttt ttgataatct catgaccaaa atcccttaac     4380

gtgagttttc gttccactga gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag     4440

atcctttttt tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg     4500

tggtttgttt gccggatcaa gagctaccaa ctctttttcc gaaggtaact ggcttcagca     4560

gagcgcagat accaaatact gtccttctag tgtagccgta gttaggccac cacttcaaga     4620

actctgtagc accgcctaca tacctcgctc tgctaatcct gttaccagtg gctgctgcca     4680

gtggcgataa gtcgtgtctt accgggttgg actcaagacg atagttaccg gataaggcgc     4740

agcggtcggg ctgaacgggg ggttcgtgca cacagcccag cttggagcga acgacctaca     4800

ccgaactgag atacctacag cgtgagctat gagaaagcgc cacgcttccc gaagggagaa     4860

aggcggacag gtatccggta agcggcaggg tcggaacagg agagcgcacg agggagcttc     4920

cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc     4980

gtcgattttt gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg     5040

cctttttacg gttcctgggc ttttgctggc cttttgctca catgttcttg actctt         5096


<210>  137
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR


<220>
<221>  SITE
<222>  (9)..(9)
<223>  Xaa is Thr or Ala

<400>  137

Gln Arg Tyr Asn Arg Ala Pro Tyr Xaa 
1               5                   


<210>  138
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR


<220>
<221>  SITE
<222>  (12)..(12)
<223>  Xaa is Tyr or Asn

<400>  138

Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Xaa 
1               5                   10          


<210>  139
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR

<400>  139

Ala Ala Ser Thr Leu Gln Ser 
1               5           


<210>  140
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR

<400>  140

Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  141
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR

<400>  141

Arg Ala Ser Gln Gly Ile Arg Asn Tyr Leu Ala 
1               5                   10      


<210>  142
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR

<400>  142

Asp Tyr Ala Met His 
1               5   


<210>  143
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR

<400>  143

Gln Lys Tyr Asn Ser Ala Pro Tyr Ala 
1               5                   


<210>  144
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR

<400>  144

Gln Lys Tyr Asn Arg Ala Pro Tyr Ala 
1               5                   


<210>  145
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR

<400>  145

Gln Lys Tyr Gln Arg Ala Pro Tyr Thr 
1               5                   


<210>  146
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR

<400>  146

Gln Lys Tyr Ser Ser Ala Pro Tyr Thr 
1               5                   


<210>  147
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR

<400>  147

Gln Lys Tyr Asn Ser Ala Pro Tyr Thr 
1               5                   


<210>  148
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR

<400>  148

Gln Lys Tyr Asn Arg Ala Pro Tyr Thr 
1               5                   


<210>  149
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR

<400>  149

Gln Lys Tyr Asn Ser Ala Pro Tyr Tyr 
1               5                   


<210>  150
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR

<400>  150

Gln Lys Tyr Asn Ser Ala Pro Tyr Asn 
1               5                   


<210>  151
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR

<400>  151

Gln Lys Tyr Thr Ser Ala Pro Tyr Thr 
1               5                   


<210>  152
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR

<400>  152

Gln Lys Tyr Asn Arg Ala Pro Tyr Asn 
1               5                   


<210>  153
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR

<400>  153

Gln Lys Tyr Asn Ser Ala Ala Tyr Ser 
1               5                   


<210>  154
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR

<400>  154

Gln Gln Tyr Asn Ser Ala Pro Asp Thr 
1               5                   


<210>  155
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR

<400>  155

Gln Lys Tyr Asn Ser Asp Pro Tyr Thr 
1               5                   


<210>  156
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR

<400>  156

Gln Lys Tyr Ile Ser Ala Pro Tyr Thr 
1               5                   


<210>  157
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR

<400>  157

Gln Lys Tyr Asn Arg Pro Pro Tyr Thr 
1               5                   


<210>  158
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR

<400>  158

Gln Arg Tyr Asn Arg Ala Pro Tyr Ala 
1               5                   


<210>  159
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR

<400>  159

Ala Ser Tyr Leu Ser Thr Ser Ser Ser Leu Asp Asn 
1               5                   10          


<210>  160
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR

<400>  160

Ala Ser Tyr Leu Ser Thr Ser Ser Ser Leu Asp Lys 
1               5                   10          


<210>  161
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR

<400>  161

Ala Ser Tyr Leu Ser Thr Ser Ser Ser Leu Asp Tyr 
1               5                   10          


<210>  162
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR

<400>  162

Ala Ser Tyr Leu Ser Thr Ser Ser Ser Leu Asp Asp 
1               5                   10          


<210>  163
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR

<400>  163

Ala Ser Tyr Leu Ser Thr Ser Phe Ser Leu Asp Tyr 
1               5                   10          


<210>  164
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR

<400>  164

Ala Ser Tyr Leu Ser Thr Ser Ser Ser Leu His Tyr 
1               5                   10          


<210>  165
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR

<400>  165

Ala Ser Phe Leu Ser Thr Ser Ser Ser Leu Glu Tyr 
1               5                   10          


<210>  166
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR

<400>  166

Ala Ser Tyr Leu Ser Thr Ala Ser Ser Leu Glu Tyr 
1               5                   10          


<210>  167
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CDR

<400>  167

Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Asn 
1               5                   10          


<210>  168
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  168

Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys Pro Lys Pro Leu Ser 
1               5                   10                  15      


Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly Leu Leu Leu Leu Gln 
            20                  25                  30          


Ala Val Ser Trp Ala Ser Gly Ala Arg Pro Cys Ile Pro Lys Ser Phe 
        35                  40                  45              


Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr Cys Asp Ser 
    50                  55                  60                  


Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser Arg Tyr Glu 
65                  70                  75                  80  


Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly Pro Ile Gln 
                85                  90                  95      


Ala Asn His Thr Gly Thr Gly Leu Leu Leu Thr Leu Gln Pro Glu Gln 
            100                 105                 110         


Lys Phe Gln Lys Val Lys Gly Phe Gly Gly Ala Met Thr Asp Ala Ala 
        115                 120                 125             


Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro Ala Gln Asn Leu Leu Leu 
    130                 135                 140                 


Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly Tyr Asn Ile Ile Arg Val 
145                 150                 155                 160 


Pro Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr Tyr Ala Asp 
                165                 170                 175     


Thr Pro Asp Asp Phe Gln Leu His Asn Phe Ser Leu Pro Glu Glu Asp 
            180                 185                 190         


Thr Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu Ala Gln 
        195                 200                 205             


Arg Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr Trp Leu 
    210                 215                 220                 


Lys Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly Gln Pro 
225                 230                 235                 240 


Gly Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys Phe Leu 
                245                 250                 255     


Asp Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr Ala Glu 
            260                 265                 270         


Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln Cys Leu 
        275                 280                 285             


Gly Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp Leu Gly 
    290                 295                 300                 


Pro Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu Met Leu 
305                 310                 315                 320 


Asp Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val Leu Thr 
                325                 330                 335     


Asp Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His Trp Tyr 
            340                 345                 350         


Leu Asp Phe Leu Ala Pro Ala Lys Ala Thr Leu Gly Glu Thr His Arg 
        355                 360                 365             


Leu Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Ala Cys Val Gly Ser 
    370                 375                 380                 


Lys Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg Gly Met 
385                 390                 395                 400 


Gln Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val Val Gly 
                405                 410                 415     


Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro Asn Trp 
            420                 425                 430         


Val Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr Lys Asp 
        435                 440                 445             


Thr Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe Ser Lys 
    450                 455                 460                 


Phe Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser Gln Lys 
465                 470                 475                 480 


Asn Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser Ala Val 
                485                 490                 495     


Val Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr Ile Lys 
            500                 505                 510         


Asp Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr Ser Ile 
        515                 520                 525             


His Thr Tyr Leu Trp Arg Arg Gln 
    530                 535     


<210>  169
<211>  380
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CMV Enhancer

<400>  169
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggactatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg                                                  380


<210>  170
<211>  204
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CMV promoter

<400>  170
gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt       60

ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac      120

tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg      180

tgggaggtct atataagcag agct                                             204


<210>  171
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  171
ggtttagtga accgtcagat cc                                                22


<210>  172
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Multiple cloning site (MSC)

<400>  172
gctagcgcta ccggactcag atctcgagct caagcttcga attctgcagt cgacggtacc       60

gcgggcccgg gatccaccgg t                                                 81


<210>  173
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  173
cgccacg                                                                  7


<210>  174
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Albumin signal peptide

<400>  174
atgaagtggg tgaccttcat cagcctgctg ttcctgtttt cttccgccta cagc             54


<210>  175
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Adalimumab variable heavy (VH) domain

<400>  175
gaagtgcagc tggttgaaag cggaggcgga ctggtccagc caggcagaag cctgagactg       60

tcttgtgccg cctctggctt cacctttgac gactacgcca tgcactgggt gcggcaggcc      120

cctggcaagg gactcgagtg ggtcagcgcc atcacctgga atagcggcca catcgactac      180

gcagatagcg ttgaaggcag attcaccatc tccagggaca acgccaagaa ttctctgtac      240

ctgcagatga acagcctgcg ggccgaggat accgctgtgt actactgcgc caaagtgtcc      300

tacctgagca ccgccagctc cctggactac tggggccagg gcaccctggt gacagtgagc      360

tct                                                                    363


<210>  176
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hIgG1 constant heavy (CH) domain

<400>  176
gctagcacaa aaggacctag cgtgtttccc ctggccccta gcagcaaaag caccagcggc       60

ggaaccgccg ctctgggttg tctggtgaag gactatttcc ctgaacctgt gaccgtgtcc      120

tggaactctg gcgccctgac tagcggcgtg cataccttcc ctgccgtgct gcaaagctct      180

ggcctgtata gcctttcttc tgtggtgacc gtgcctagca gctctctggg cacacagaca      240

tacatctgca atgtgaacca caagccctcc aacaccaagg tggacaaaaa ggtggaaccc      300

aagagctgcg acaagaccca cacctgtcct ccgtgccccg ctcctgagct gctgggcggc      360

ccttctgtgt tcctgttccc ccccaaacct aaagacacac tgatgatcag ccggacccct      420

gaggtgacct gcgtggtggt ggacgtgagc cacgaggacc ccgaggtgaa gttcaactgg      480

tacgtggacg gcgtggaggt ccacaacgcc aagaccaaac ctagagagga acaatacaac      540

agcacatata gagtggtgtc tgtgctgaca gtgctccacc aggactggct gaacggaaag      600

gaatacaagt gcaaggtgtc caacaaggcc ctccctgctc caatcgagaa gaccattagc      660

aaggccaagg gccaacctag agagccccag gtctacaccc tgccaccaag tagagatgag      720

ctgaccaaga accaggtgag cctaacatgc ctggtgaagg gcttttaccc cagcgacatc      780

gccgtggaat gggagagcaa cggccagcct gagaacaact acaagacaac acctcctgtt      840

ctggattctg atggcagctt cttcctgtac agcaagctga cagtggataa gagccggtgg      900

cagcagggca acgtgttcag ctgctccgtt atgcacgagg ccctgcataa tcactacacc      960

cagaagagcc tgtctctgag ccctggcaag                                       990


<210>  177
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Furin cleavage site

<400>  177
cgaaaacggc gc                                                           12


<210>  178
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  GSG linker

<400>  178
ggaagcgga                                                                9


<210>  179
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  P2A cleavage site

<400>  179
gctactaact tcagcctgct gaagcaggct ggagatgtgg aggagaaccc tggacct          57


<210>  180
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Albumin signal peptide

<400>  180
atgaagtggg tgaccttcat cagcctgctg ttcctgtttt cttccgccta cagc             54


<210>  181
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Adalimumab variable light (VL) chain

<400>  181
gatatccaga tgacccagtc tccatctagc ctgagcgcca gcgtgggaga tagagtgacc       60

atcacctgta gagcctctca aggcatccgg aactacctgg cctggtatca gcagaaacct      120

ggcaaggctc ctaagctgct gatctacgcc gcttccaccc tgcagagcgg cgttccttct      180

agattcagcg gcagcggctc cggaacagac ttcaccctga caattagctc cctgcaacct      240

gaagatgtgg ctacatacta ctgccagaga tacaatcggg ccccttacac ctttggacag      300

ggcaccaagg tggaaatcaa g                                                321


<210>  182
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hIgG kappa constant light (CL) chain

<400>  182
cggaccgtgg ccgccccatc tgtgttcatc ttccccccca gcgacgagca gctgaaaagc       60

ggcacagcca gcgtggtgtg cctgctgaac aacttctacc ccagggaagc caaggtgcag      120

tggaaggtgg acaatgccct gcagagcggc aacagccagg agagcgtgac cgagcaggac      180

agcaaggaca gcacctacag cctgagcagc accctcacac tgtctaaagc cgactacgag      240

aagcacaagg tctacgcctg cgaggtgacc caccagggcc tgtcctcccc tgtgacaaag      300

agctttaaca gaggcgagtg c                                                321


<210>  183
<211>  3
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Stop codon

<400>  183
taa                                                                      3


<210>  184
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  184
atcataatca gccataccac atttgtagag gttttacttg ctttaaaaaa cctcccacac       60

ctccccctga acctgaaaca taaaatgaat gcaattgttg ttgtt                      105


<210>  185
<211>  122
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  SV40 polyadenylation signal

<400>  185
aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca       60

aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct      120

ta                                                                     122


<210>  186
<211>  178
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  186
aggcgtcttc tactgggcgg ttttatggac agcaagcgaa ccggaattgc cagctggggc       60

gccctctggt aaggttggga agccctgcaa agtaaactgg atggctttct tgccgccaag      120

gatctgatgg cgcaggggat caagctctga tcaagagaca ggatgaggat cgtttcgc        178


<210>  187
<211>  795
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Neomycin/Kanamycin resistance gene

<400>  187
atgattgaac aagatggatt gcacgcaggt tctccggccg cttgggtgga gaggctattc       60

ggctatgact gggcacaaca gacaatcggc tgctctgatg ccgccgtgtt ccggctgtca      120

gcgcaggggc gcccggttct ttttgtcaag accgacctgt ccggtgccct gaatgaactg      180

caagacgagg cagcgcggct atcgtggctg gccacgacgg gcgttccttg cgcagctgtg      240

ctcgacgttg tcactgaagc gggaagggac tggctgctat tgggcgaagt gccggggcag      300

gatctcctgt catctcacct tgctcctgcc gagaaagtat ccatcatggc tgatgcaatg      360

cggcggctgc atacgcttga tccggctacc tgcccattcg accaccaagc gaaacatcgc      420

atcgagcgag cacgtactcg gatggaagcc ggtcttgtcg atcaggatga tctggacgaa      480

gagcatcagg ggctcgcgcc agccgaactg ttcgccaggc tcaaggcgag catgcccgac      540

ggcgaggatc tcgtcgtgac ccatggcgat gcctgcttgc cgaatatcat ggtggaaaat      600

ggccgctttt ctggattcat cgactgtggc cggctgggtg tggcggaccg ctatcaggac      660

atagcgttgg ctacccgtga tattgctgaa gagcttggcg gcgaatgggc tgaccgcttc      720

ctcgtgcttt acggtatcgc cgctcccgat tcgcagcgca tcgccttcta tcgccttctt      780

gacgagttct tctga                                                       795


<210>  188
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  188
attattaacg cttacaattt cctgatgcgg tattttctcc ttacgcatct gtgcggtatt       60

tcacaccgca tacaggtggc acttttcggg gaaatgtgcg cggaacccct atttgtttat      120

ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga taaatgcttc      180

aataatagca cgtgctaaaa cttcattttt aatttaaaag gatctaggtg aagatccttt      240

ttgataatct catgaccaaa atcccttaac gtgagttttc gttccactga gcgtcagacc      300

ccgtagaaaa gatcaaagga tcttc                                            325


<210>  189
<211>  589
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Ori

<400>  189
ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc       60

agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt      120

cagcagagcg cagataccaa atactgtcct tctagtgtag ccgtagttag gccaccactt      180

caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc      240

tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa      300

ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac      360

ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg      420

gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga      480

gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact      540

tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaa                  589


<210>  190
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  190
aacgccagca acgcggcctt tttacggttc ctgggctttt gctggccttt tgctcacatg       60

ttcttgactc ttcgcgatgt acgggccaga tatacgcgtt                            100


<210>  191
<211>  380
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CMV Enhancer

<400>  191
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggactatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg                                                  380


<210>  192
<211>  204
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CMV promoter

<400>  192
gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt       60

ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac      120

tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg      180

tgggaggtct atataagcag agct                                             204


<210>  193
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  193
ggtttagtga accgtcagat cc                                                22


<210>  194
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Multiple cloning site (MSC)

<400>  194
gctagcgcta ccggactcag atctcgagct caagcttcga attctgcagt cgacggtacc       60

gcgggcccgg gatccaccgg t                                                 81


<210>  195
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  195
cgccacg                                                                  7


<210>  196
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Albumin signal peptide

<400>  196
atgaagtggg tgaccttcat cagcctgctg ttcctgtttt cttccgccta cagc             54


<210>  197
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Adalimumab variable heavy (VH) domain

<400>  197
gaagtgcagc tggttgaaag cggaggcgga ctggtccagc caggcagaag cctgagactg       60

tcttgtgccg cctctggctt cacctttgac gactacgcca tgcactgggt gcggcaggcc      120

cctggcaagg gactcgagtg ggtcagcgcc atcacctgga atagcggcca catcgactac      180

gcagatagcg ttgaaggcag attcaccatc tccagggaca acgccaagaa ttctctgtac      240

ctgcagatga acagcctgcg ggccgaggat accgctgtgt actactgcgc caaagtgtcc      300

tacctgagca ccgccagctc cctggactac tggggccagg gcaccctggt gacagtgagc      360

tct                                                                    363


<210>  198
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hIgG1 constant heavy (CH) domain

<400>  198
gctagcacaa aaggacctag cgtgtttccc ctggccccta gcagcaaaag caccagcggc       60

ggaaccgccg ctctgggttg tctggtgaag gactatttcc ctgaacctgt gaccgtgtcc      120

tggaactctg gcgccctgac tagcggcgtg cataccttcc ctgccgtgct gcaaagctct      180

ggcctgtata gcctttcttc tgtggtgacc gtgcctagca gctctctggg cacacagaca      240

tacatctgca atgtgaacca caagccctcc aacaccaagg tggacaaaaa ggtggaaccc      300

aagagctgcg acaagaccca cacctgtcct ccgtgccccg ctcctgagct gctgggcggc      360

ccttctgtgt tcctgttccc ccccaaacct aaagacacac tgatgatcag ccggacccct      420

gaggtgacct gcgtggtggt ggacgtgagc cacgaggacc ccgaggtgaa gttcaactgg      480

tacgtggacg gcgtggaggt ccacaacgcc aagaccaaac ctagagagga acaatacaac      540

agcacatata gagtggtgtc tgtgctgaca gtgctccacc aggactggct gaacggaaag      600

gaatacaagt gcaaggtgtc caacaaggcc ctccctgctc caatcgagaa gaccattagc      660

aaggccaagg gccaacctag agagccccag gtctacaccc tgccaccaag tagagatgag      720

ctgaccaaga accaggtgag cctaacatgc ctggtgaagg gcttttaccc cagcgacatc      780

gccgtggaat gggagagcaa cggccagcct gagaacaact acaagacaac acctcctgtt      840

ctggattctg atggcagctt cttcctgtac agcaagctga cagtggataa gagccggtgg      900

cagcagggca acgtgttcag ctgctccgtt atgcacgagg ccctgcataa tcactacacc      960

cagaagagcc tgtctctgag ccctggcaag                                       990


<210>  199
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Furin cleavage site

<400>  199
cgaaaacggc gc                                                           12


<210>  200
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  GSG linker

<400>  200
ggaagcgga                                                                9


<210>  201
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  P2A cleavage site

<400>  201
gctactaact tcagcctgct gaagcaggct ggagatgtgg aggagaaccc tggacct          57


<210>  202
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Albumin signal peptide

<400>  202
atgaagtggg tgaccttcat cagcctgctg ttcctgtttt cttccgccta cagc             54


<210>  203
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Adalimumab variable light (VL) chain

<400>  203
gatatccaga tgacccagtc tccatctagc ctgagcgcca gcgtgggaga tagagtgacc       60

atcacctgta gagcctctca aggcatccgg aactacctgg cctggtatca gcagaaacct      120

ggcaaggctc ctaagctgct gatctacgcc gcttccaccc tgcagagcgg cgttccttct      180

agattcagcg gcagcggctc cggaacagac ttcaccctga caattagctc cctgcaacct      240

gaagatgtgg ctacatacta ctgccagaga tacaatcggg ccccttacac ctttggacag      300

ggcaccaagg tggaaatcaa g                                                321


<210>  204
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hIgG kappa constant light (CL) chain

<400>  204
cggaccgtgg ccgccccatc tgtgttcatc ttccccccca gcgacgagca gctgaaaagc       60

ggcacagcca gcgtggtgtg cctgctgaac aacttctacc ccagggaagc caaggtgcag      120

tggaaggtgg acaatgccct gcagagcggc aacagccagg agagcgtgac cgagcaggac      180

agcaaggaca gcacctacag cctgagcagc accctcacac tgtctaaagc cgactacgag      240

aagcacaagg tctacgcctg cgaggtgacc caccagggcc tgtcctcccc tgtgacaaag      300

agctttaaca gaggcgagtg c                                                321


<210>  205
<211>  3
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Stop codon

<400>  205
taa                                                                      3


<210>  206
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  206
cccccccccc ta                                                           12


<210>  207
<211>  552
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Internal ribosome entry site (IRES) (non-coding)

<400>  207
acgttactgg ccgaagccgc ttggaataag gccggtgtgc gtttgtctat atgttatttt       60

ccaccatatt gccgtctttt ggcaatgtga gggcccggaa acctggccct gtcttcttga      120

cgagcattcc taggggtctt tcccctctcg ccaaaggaat gcaaggtctg ttgaatgtcg      180

tgaaggaagc agttcctctg gaagcttctt gaagacaaac aacgtctgta gcgacccttt      240

gcaggcagcg gaacccccca cctggcgaca ggtgcctctg cggccaaaag ccacgtgtat      300

aagatacacc tgcaaaggcg gcacaacccc agtgccacgt tgtgagttgg atagttgtgg      360

aaagagtcaa atggctctcc tcaagcgtat tcaacaaggg gctgaaggat gcccagaagg      420

taccccattg tatgggatct gatctggggc ctcggtgcac atgctttaca tgtgtttagt      480

cgaggttaaa aaaacgtcta ggccccccga accacgggga cgtggttttc ctttgaaaaa      540

cacgatgata at                                                          552


<210>  208
<211>  201
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Enhancer protein L

<400>  208
atggccacaa ccatggaaca agagacttgc gcgcactctc tcacttttga ggaatgccca       60

aaatgctctg ctctacaata ccgtaatgga ttttacctgc taaagtatga tgaagaatgg      120

tacccagagg agttattgac tgatggagag gatgatgtct ttgatcccga attagacatg      180

gaagtcgttt tcgagttaca g                                                201


<210>  209
<211>  3
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Stop codon

<400>  209
taa                                                                      3


<210>  210
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  210
atcataatca gccataccac atttgtagag gttttacttg ctttaaaaaa cctcccacac       60

ctccccctga acctgaaaca taaaatgaat gcaattgttg ttgtt                      105


<210>  211
<211>  122
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  SV40 polyadenylation signal

<400>  211
aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca       60

aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct      120

ta                                                                     122


<210>  212
<211>  178
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  212
aggcgtcttc tactgggcgg ttttatggac agcaagcgaa ccggaattgc cagctggggc       60

gccctctggt aaggttggga agccctgcaa agtaaactgg atggctttct tgccgccaag      120

gatctgatgg cgcaggggat caagctctga tcaagagaca ggatgaggat cgtttcgc        178


<210>  213
<211>  795
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Neomycin/Kanamycin resistance gene

<400>  213
atgattgaac aagatggatt gcacgcaggt tctccggccg cttgggtgga gaggctattc       60

ggctatgact gggcacaaca gacaatcggc tgctctgatg ccgccgtgtt ccggctgtca      120

gcgcaggggc gcccggttct ttttgtcaag accgacctgt ccggtgccct gaatgaactg      180

caagacgagg cagcgcggct atcgtggctg gccacgacgg gcgttccttg cgcagctgtg      240

ctcgacgttg tcactgaagc gggaagggac tggctgctat tgggcgaagt gccggggcag      300

gatctcctgt catctcacct tgctcctgcc gagaaagtat ccatcatggc tgatgcaatg      360

cggcggctgc atacgcttga tccggctacc tgcccattcg accaccaagc gaaacatcgc      420

atcgagcgag cacgtactcg gatggaagcc ggtcttgtcg atcaggatga tctggacgaa      480

gagcatcagg ggctcgcgcc agccgaactg ttcgccaggc tcaaggcgag catgcccgac      540

ggcgaggatc tcgtcgtgac ccatggcgat gcctgcttgc cgaatatcat ggtggaaaat      600

ggccgctttt ctggattcat cgactgtggc cggctgggtg tggcggaccg ctatcaggac      660

atagcgttgg ctacccgtga tattgctgaa gagcttggcg gcgaatgggc tgaccgcttc      720

ctcgtgcttt acggtatcgc cgctcccgat tcgcagcgca tcgccttcta tcgccttctt      780

gacgagttct tctga                                                       795


<210>  214
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  214
attattaacg cttacaattt cctgatgcgg tattttctcc ttacgcatct gtgcggtatt       60

tcacaccgca tacaggtggc acttttcggg gaaatgtgcg cggaacccct atttgtttat      120

ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga taaatgcttc      180

aataatagca cgtgctaaaa cttcattttt aatttaaaag gatctaggtg aagatccttt      240

ttgataatct catgaccaaa atcccttaac gtgagttttc gttccactga gcgtcagacc      300

ccgtagaaaa gatcaaagga tcttc                                            325


<210>  215
<211>  589
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Ori

<400>  215
ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc       60

agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt      120

cagcagagcg cagataccaa atactgtcct tctagtgtag ccgtagttag gccaccactt      180

caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc      240

tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa      300

ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac      360

ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg      420

gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga      480

gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact      540

tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaa                  589


<210>  216
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  216
aacgccagca acgcggcctt tttacggttc ctgggctttt gctggccttt tgctcacatg       60

ttcttgactc ttcgcgatgt acgggccaga tatacgcgtt                            100


<210>  217
<211>  141
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  5' inverted terminal repeat (ITR)

<400>  217
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc t                                                141


<210>  218
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  218
tctagacaac tttgtataga aaagttg                                           27


<210>  219
<211>  589
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CMV enhancer and promoter

<400>  219
tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg       60

cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt      120

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      180

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      240

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      300

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      360

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      420

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      480

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      540

acggtgggag gtctatataa gcagagctgg tttagtgaac cgtcagatc                  589


<210>  220
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  220
caagtttgta caaaaaagca ggctgccacc                                        30


<210>  221
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Albumin signal peptide

<400>  221
atgaagtggg tgaccttcat cagcctgctg ttcctgtttt cttccgccta cagc             54


<210>  222
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Adalimumab variable heavy (VH) domain

<400>  222
gaagtgcagc tggttgaaag cggaggcgga ctggtccagc caggcagaag cctgagactg       60

tcttgtgccg cctctggctt cacctttgac gactacgcca tgcactgggt gcggcaggcc      120

cctggcaagg gactcgagtg ggtcagcgcc atcacctgga atagcggcca catcgactac      180

gcagatagcg ttgaaggcag attcaccatc tccagggaca acgccaagaa ttctctgtac      240

ctgcagatga acagcctgcg ggccgaggat accgctgtgt actactgcgc caaagtgtcc      300

tacctgagca ccgccagctc cctggactac tggggccagg gcaccctggt gacagtgagc      360

tct                                                                    363


<210>  223
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hIgG1 constant heavy (CH) domain

<400>  223
gctagcacaa aaggacctag cgtgtttccc ctggccccta gcagcaaaag caccagcggc       60

ggaaccgccg ctctgggttg tctggtgaag gactatttcc ctgaacctgt gaccgtgtcc      120

tggaactctg gcgccctgac tagcggcgtg cataccttcc ctgccgtgct gcaaagctct      180

ggcctgtata gcctttcttc tgtggtgacc gtgcctagca gctctctggg cacacagaca      240

tacatctgca atgtgaacca caagccctcc aacaccaagg tggacaaaaa ggtggaaccc      300

aagagctgcg acaagaccca cacctgtcct ccgtgccccg ctcctgagct gctgggcggc      360

ccttctgtgt tcctgttccc ccccaaacct aaagacacac tgatgatcag ccggacccct      420

gaggtgacct gcgtggtggt ggacgtgagc cacgaggacc ccgaggtgaa gttcaactgg      480

tacgtggacg gcgtggaggt ccacaacgcc aagaccaaac ctagagagga acaatacaac      540

agcacatata gagtggtgtc tgtgctgaca gtgctccacc aggactggct gaacggaaag      600

gaatacaagt gcaaggtgtc caacaaggcc ctccctgctc caatcgagaa gaccattagc      660

aaggccaagg gccaacctag agagccccag gtctacaccc tgccaccaag tagagatgag      720

ctgaccaaga accaggtgag cctaacatgc ctggtgaagg gcttttaccc cagcgacatc      780

gccgtggaat gggagagcaa cggccagcct gagaacaact acaagacaac acctcctgtt      840

ctggattctg atggcagctt cttcctgtac agcaagctga cagtggataa gagccggtgg      900

cagcagggca acgtgttcag ctgctccgtt atgcacgagg ccctgcataa tcactacacc      960

cagaagagcc tgtctctgag ccctggcaag                                       990


<210>  224
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Furin cleavage site

<400>  224
cgaaaacggc gc                                                           12


<210>  225
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  GSG linker

<400>  225
ggaagcgga                                                                9


<210>  226
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  P2A cleavage site

<400>  226
gctactaact tcagcctgct gaagcaggct ggagatgtgg aggagaaccc tggacct          57


<210>  227
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Albumin signal peptide

<400>  227
atgaagtggg tgaccttcat cagcctgctg ttcctgtttt cttccgccta cagc             54


<210>  228
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Adalimumab variable light (VL) chain

<400>  228
gatatccaga tgacccagtc tccatctagc ctgagcgcca gcgtgggaga tagagtgacc       60

atcacctgta gagcctctca aggcatccgg aactacctgg cctggtatca gcagaaacct      120

ggcaaggctc ctaagctgct gatctacgcc gcttccaccc tgcagagcgg cgttccttct      180

agattcagcg gcagcggctc cggaacagac ttcaccctga caattagctc cctgcaacct      240

gaagatgtgg ctacatacta ctgccagaga tacaatcggg ccccttacac ctttggacag      300

ggcaccaagg tggaaatcaa g                                                321


<210>  229
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hIgG kappa constant light (CL) chain

<400>  229
cggaccgtgg ccgccccatc tgtgttcatc ttccccccca gcgacgagca gctgaaaagc       60

ggcacagcca gcgtggtgtg cctgctgaac aacttctacc ccagggaagc caaggtgcag      120

tggaaggtgg acaatgccct gcagagcggc aacagccagg agagcgtgac cgagcaggac      180

agcaaggaca gcacctacag cctgagcagc accctcacac tgtctaaagc cgactacgag      240

aagcacaagg tctacgcctg cgaggtgacc caccagggcc tgtcctcccc tgtgacaaag      300

agctttaaca gaggcgagtg c                                                321


<210>  230
<211>  3
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Stop codon

<400>  230
taa                                                                      3


<210>  231
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  231
acccagcttt cttgtacaaa gtgggaattc ctagagctcg ctgatcagcc tcga             54


<210>  232
<211>  208
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  BGH polyadenylation signal

<400>  232
ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc       60

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc      120

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt      180

gggaagagaa tagcaggcat gctgggga                                         208


<210>  233
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  233
gggccgc                                                                  7


<210>  234
<211>  141
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  3' inverted terminal repeat (ITR)

<400>  234
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag ctgcctgcag g                                                141


<210>  235
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  235
ggcgcctgat gcggtatttt ctccttacgc atctgtgcgg tatttcacac cgcatacgtc       60

aaagcaacca tagt                                                         74


<210>  236
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  F1 ori

<400>  236
acgcgccctg tagcggcgca ttaagcgcgg cgggggtggt ggttacgcgc agcgtgaccg       60

ctacacttgc cagcgcctta gcgcccgctc ctttcgcttt cttcccttcc tttctcgcca      120

cgttcgccgg ctttccccgt caagctctaa atcgggggct ccctttaggg ttccgattta      180

gtgctttacg gcacctcgac cccaaaaaac ttgatttggg tgatggttca cgtagtgggc      240

catcgccctg atagacggtt tttcgccctt tgacgttgga gtccacgttc tttaatagtg      300

gactcttgtt ccaaactgga acaacactca actctatctc gggctattct tttgatttat      360

aagggatttt gccgatttcg gtctattggt taaaaaatga gctgatttaa caaaaattta      420

acgcgaattt taacaaaata ttaacgttta caattt                                456


<210>  237
<211>  281
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  237
tatggtgcac tctcagtaca atctgctctg atgccgcata gttaagccag ccccgacacc       60

cgccaacacc cgctgacgcg ccctgacggg cttgtctgct cccggcatcc gcttacagac      120

aagctgtgac cgtctccggg agctgcatgt gtcagaggtt ttcaccgtca tcaccgaaac      180

gcgcgagacg aaagggcctc gtgatacgcc tatttttata ggttaatgtc atgataataa      240

tggtttctta gacgtcaggt ggcacttttc ggggaaatgt g                          281


<210>  238
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  AmpR promoter

<400>  238
cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga       60

caataaccct gataaatgct tcaataatat tgaaaaagga agagt                      105


<210>  239
<211>  861
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  AmpR gene

<400>  239
atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt ttgccttcct       60

gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca      120

cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag ttttcgcccc      180

gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc ggtattatcc      240

cgtattgacg ccgggcaaga gcaactcggt cgccgcatac actattctca gaatgacttg      300

gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt aagagaatta      360

tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct gacaacgatc      420

ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt aactcgcctt      480

gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga caccacgatg      540

cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact tactctagct      600

tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc acttctgcgc      660

tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga gcgtggaagc      720

cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt agttatctac      780

acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga gataggtgcc      840

tcactgatta agcattggta a                                                861


<210>  240
<211>  170
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  240
ctgtcagacc aagtttactc atatatactt tagattgatt taaaacttca tttttaattt       60

aaaaggatct aggtgaagat cctttttgat aatctcatga ccaaaatccc ttaacgtgag      120

ttttcgttcc actgagcgtc agaccccgta gaaaagatca aaggatcttc                 170


<210>  241
<211>  589
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pUC ori

<400>  241
ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc       60

agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt      120

cagcagagcg cagataccaa atactgttct tctagtgtag ccgtagttag gccaccactt      180

caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc      240

tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa      300

ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac      360

ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg      420

gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga      480

gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact      540

tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaa                  589


<210>  242
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  242
aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt tgctcacatg       60

t                                                                       61


<210>  243
<211>  141
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  5' inverted terminal repeat (ITR)

<400>  243
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc t                                                141


<210>  244
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  244
tctagacaac tttgtataga aaagttg                                           27


<210>  245
<211>  589
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CMV enhancer and promoter

<400>  245
tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg       60

cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt      120

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      180

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      240

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      300

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      360

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      420

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      480

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      540

acggtgggag gtctatataa gcagagctgg tttagtgaac cgtcagatc                  589


<210>  246
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  246
caagtttgta caaaaaagca ggctgccacc                                        30


<210>  247
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Albumin signal peptide

<400>  247
atgaagtggg tgaccttcat cagcctgctg ttcctgtttt cttccgccta cagc             54


<210>  248
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Adalimumab variable heavy (VH) domain

<400>  248
gaagtgcagc tggttgaaag cggaggcgga ctggtccagc caggcagaag cctgagactg       60

tcttgtgccg cctctggctt cacctttgac gactacgcca tgcactgggt gcggcaggcc      120

cctggcaagg gactcgagtg ggtcagcgcc atcacctgga atagcggcca catcgactac      180

gcagatagcg ttgaaggcag attcaccatc tccagggaca acgccaagaa ttctctgtac      240

ctgcagatga acagcctgcg ggccgaggat accgctgtgt actactgcgc caaagtgtcc      300

tacctgagca ccgccagctc cctggactac tggggccagg gcaccctggt gacagtgagc      360

tct                                                                    363


<210>  249
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hIgG1 constant heavy (CH) domain

<400>  249
gctagcacaa aaggacctag cgtgtttccc ctggccccta gcagcaaaag caccagcggc       60

ggaaccgccg ctctgggttg tctggtgaag gactatttcc ctgaacctgt gaccgtgtcc      120

tggaactctg gcgccctgac tagcggcgtg cataccttcc ctgccgtgct gcaaagctct      180

ggcctgtata gcctttcttc tgtggtgacc gtgcctagca gctctctggg cacacagaca      240

tacatctgca atgtgaacca caagccctcc aacaccaagg tggacaaaaa ggtggaaccc      300

aagagctgcg acaagaccca cacctgtcct ccgtgccccg ctcctgagct gctgggcggc      360

ccttctgtgt tcctgttccc ccccaaacct aaagacacac tgatgatcag ccggacccct      420

gaggtgacct gcgtggtggt ggacgtgagc cacgaggacc ccgaggtgaa gttcaactgg      480

tacgtggacg gcgtggaggt ccacaacgcc aagaccaaac ctagagagga acaatacaac      540

agcacatata gagtggtgtc tgtgctgaca gtgctccacc aggactggct gaacggaaag      600

gaatacaagt gcaaggtgtc caacaaggcc ctccctgctc caatcgagaa gaccattagc      660

aaggccaagg gccaacctag agagccccag gtctacaccc tgccaccaag tagagatgag      720

ctgaccaaga accaggtgag cctaacatgc ctggtgaagg gcttttaccc cagcgacatc      780

gccgtggaat gggagagcaa cggccagcct gagaacaact acaagacaac acctcctgtt      840

ctggattctg atggcagctt cttcctgtac agcaagctga cagtggataa gagccggtgg      900

cagcagggca acgtgttcag ctgctccgtt atgcacgagg ccctgcataa tcactacacc      960

cagaagagcc tgtctctgag ccctggcaag                                       990


<210>  250
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Furin cleavage site

<400>  250
cgaaaacggc gc                                                           12


<210>  251
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  GSG linker

<400>  251
ggaagcgga                                                                9


<210>  252
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  P2A cleavage site

<400>  252
gctactaact tcagcctgct gaagcaggct ggagatgtgg aggagaaccc tggacct          57


<210>  253
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Albumin signal peptide

<400>  253
atgaagtggg tgaccttcat cagcctgctg ttcctgtttt cttccgccta cagc             54


<210>  254
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Adalimumab variable light (VL) chain

<400>  254
gatatccaga tgacccagtc tccatctagc ctgagcgcca gcgtgggaga tagagtgacc       60

atcacctgta gagcctctca aggcatccgg aactacctgg cctggtatca gcagaaacct      120

ggcaaggctc ctaagctgct gatctacgcc gcttccaccc tgcagagcgg cgttccttct      180

agattcagcg gcagcggctc cggaacagac ttcaccctga caattagctc cctgcaacct      240

gaagatgtgg ctacatacta ctgccagaga tacaatcggg ccccttacac ctttggacag      300

ggcaccaagg tggaaatcaa g                                                321


<210>  255
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hIgG kappa constant light (CL) chain

<400>  255
cggaccgtgg ccgccccatc tgtgttcatc ttccccccca gcgacgagca gctgaaaagc       60

ggcacagcca gcgtggtgtg cctgctgaac aacttctacc ccagggaagc caaggtgcag      120

tggaaggtgg acaatgccct gcagagcggc aacagccagg agagcgtgac cgagcaggac      180

agcaaggaca gcacctacag cctgagcagc accctcacac tgtctaaagc cgactacgag      240

aagcacaagg tctacgcctg cgaggtgacc caccagggcc tgtcctcccc tgtgacaaag      300

agctttaaca gaggcgagtg c                                                321


<210>  256
<211>  3
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Stop codon

<400>  256
taa                                                                      3


<210>  257
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  257
cccccccccc ta                                                           12


<210>  258
<211>  552
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Internal ribosome entry site (IRES) (non-coding)

<400>  258
acgttactgg ccgaagccgc ttggaataag gccggtgtgc gtttgtctat atgttatttt       60

ccaccatatt gccgtctttt ggcaatgtga gggcccggaa acctggccct gtcttcttga      120

cgagcattcc taggggtctt tcccctctcg ccaaaggaat gcaaggtctg ttgaatgtcg      180

tgaaggaagc agttcctctg gaagcttctt gaagacaaac aacgtctgta gcgacccttt      240

gcaggcagcg gaacccccca cctggcgaca ggtgcctctg cggccaaaag ccacgtgtat      300

aagatacacc tgcaaaggcg gcacaacccc agtgccacgt tgtgagttgg atagttgtgg      360

aaagagtcaa atggctctcc tcaagcgtat tcaacaaggg gctgaaggat gcccagaagg      420

taccccattg tatgggatct gatctggggc ctcggtgcac atgctttaca tgtgtttagt      480

cgaggttaaa aaaacgtcta ggccccccga accacgggga cgtggttttc ctttgaaaaa      540

cacgatgata at                                                          552


<210>  259
<211>  201
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Enhancer protein L

<400>  259
atggccacaa ccatggaaca agagacttgc gcgcactctc tcacttttga ggaatgccca       60

aaatgctctg ctctacaata ccgtaatgga ttttacctgc taaagtatga tgaagaatgg      120

tacccagagg agttattgac tgatggagag gatgatgtct ttgatcccga attagacatg      180

gaagtcgttt tcgagttaca g                                                201


<210>  260
<211>  3
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Stop codon

<400>  260
taa                                                                      3


<210>  261
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  261
acccagcttt cttgtacaaa gtgggaattc ctagagctcg ctgatcagcc tcga             54


<210>  262
<211>  208
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  BGH polyadenylation signal

<400>  262
ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc       60

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc      120

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt      180

gggaagagaa tagcaggcat gctgggga                                         208


<210>  263
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  263
gggccgc                                                                  7


<210>  264
<211>  141
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  3' inverted terminal repeat (ITR)

<400>  264
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag ctgcctgcag g                                                141


<210>  265
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  265
ggcgcctgat gcggtatttt ctccttacgc atctgtgcgg tatttcacac cgcatacgtc       60

aaagcaacca tagt                                                         74


<210>  266
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  F1 ori

<400>  266
acgcgccctg tagcggcgca ttaagcgcgg cgggggtggt ggttacgcgc agcgtgaccg       60

ctacacttgc cagcgcctta gcgcccgctc ctttcgcttt cttcccttcc tttctcgcca      120

cgttcgccgg ctttccccgt caagctctaa atcgggggct ccctttaggg ttccgattta      180

gtgctttacg gcacctcgac cccaaaaaac ttgatttggg tgatggttca cgtagtgggc      240

catcgccctg atagacggtt tttcgccctt tgacgttgga gtccacgttc tttaatagtg      300

gactcttgtt ccaaactgga acaacactca actctatctc gggctattct tttgatttat      360

aagggatttt gccgatttcg gtctattggt taaaaaatga gctgatttaa caaaaattta      420

acgcgaattt taacaaaata ttaacgttta caattt                                456


<210>  267
<211>  281
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  267
tatggtgcac tctcagtaca atctgctctg atgccgcata gttaagccag ccccgacacc       60

cgccaacacc cgctgacgcg ccctgacggg cttgtctgct cccggcatcc gcttacagac      120

aagctgtgac cgtctccggg agctgcatgt gtcagaggtt ttcaccgtca tcaccgaaac      180

gcgcgagacg aaagggcctc gtgatacgcc tatttttata ggttaatgtc atgataataa      240

tggtttctta gacgtcaggt ggcacttttc ggggaaatgt g                          281


<210>  268
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  AmpR promoter

<400>  268
cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga       60

caataaccct gataaatgct tcaataatat tgaaaaagga agagt                      105


<210>  269
<211>  861
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  AmpR gene

<400>  269
atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt ttgccttcct       60

gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca      120

cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag ttttcgcccc      180

gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc ggtattatcc      240

cgtattgacg ccgggcaaga gcaactcggt cgccgcatac actattctca gaatgacttg      300

gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt aagagaatta      360

tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct gacaacgatc      420

ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt aactcgcctt      480

gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga caccacgatg      540

cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact tactctagct      600

tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc acttctgcgc      660

tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga gcgtggaagc      720

cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt agttatctac      780

acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga gataggtgcc      840

tcactgatta agcattggta a                                                861


<210>  270
<211>  170
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  270
ctgtcagacc aagtttactc atatatactt tagattgatt taaaacttca tttttaattt       60

aaaaggatct aggtgaagat cctttttgat aatctcatga ccaaaatccc ttaacgtgag      120

ttttcgttcc actgagcgtc agaccccgta gaaaagatca aaggatcttc                 170


<210>  271
<211>  589
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pUC ori

<400>  271
ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc       60

agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt      120

cagcagagcg cagataccaa atactgttct tctagtgtag ccgtagttag gccaccactt      180

caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc      240

tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa      300

ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac      360

ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg      420

gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga      480

gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact      540

tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaa                  589


<210>  272
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  272
aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt tgctcacatg       60

t                                                                       61


<210>  273
<211>  304
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CMV enhancer

<400>  273
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catg                                                                   304


<210>  274
<211>  204
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CMV promoter

<400>  274
gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt       60

ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac      120

tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg      180

tgggaggtct atataagcag agct                                             204


<210>  275
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  275
ggtttagtga accgtcagat cc                                                22


<210>  276
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Multiple cloning site (MSC)

<400>  276
gctagcgcta ccggactcag atctcgagct caagcttcga attctgcagt cgacggtacc       60

gcgggcccgg gatccaccgg t                                                 81


<210>  277
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  277
cgccacc                                                                  7


<210>  278
<211>  117
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  GBA signal peptide

<400>  278
atggagtttt caagtccttc cagagaggaa tgtcccaagc ctttgagtag ggtaagcatc       60

atggctggca gcctcacagg attgcttcta cttcaggcag tgtcgtgggc atcaggt         117


<210>  279
<211>  1491
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  GBA mature protein

<400>  279
gcccgcccct gcatccctaa aagcttcggc tacagctcgg tggtgtgtgt ctgcaatgcc       60

acatactgtg actcctttga ccccccgacc tttcctgccc ttggtacctt cagccgctat      120

gagagtacac gcagtgggcg acggatggag ctgagtatgg ggcccatcca ggctaatcac      180

acgggcacag gcctgctact gaccctgcag ccagaacaga agttccagaa agtgaaggga      240

tttggagggg ccatgacaga tgctgctgct ctcaacatcc ttgccctgtc accccctgcc      300

caaaatttgc tacttaaatc gtacttctct gaagaaggaa tcggatataa catcatccgg      360

gtacccatgg ccagctgtga cttctccatc cgcacctaca cctatgcaga cacccctgat      420

gatttccagt tgcacaactt cagcctccca gaggaagata ccaagctcaa gatacccctg      480

attcaccgag ccctgcagtt ggcccagcgt cccgtttcac tccttgccag cccctggaca      540

tcacccactt ggctcaagac caatggagcg gtgaatggga aggggtcact caagggacag      600

cccggagaca tctaccacca gacctgggcc agatactttg tgaagttcct ggatgcctat      660

gctgagcaca agttacagtt ctgggcagtg acagctgaaa atgagccttc tgctgggctg      720

ttgagtggat accccttcca gtgcctgggc ttcacccctg aacatcagcg agacttcatt      780

gcccgtgacc taggtcctac cctcgccaac agtactcacc acaatgtccg cctactcatg      840

ctggatgacc aacgcttgct gctgccccac tgggcaaagg tggtactgac agacccagaa      900

gcagctaaat atgttcatgg cattgctgta cattggtacc tggactttct ggctccagcc      960

aaagccaccc taggggagac acaccgcctg ttccccaaca ccatgctctt tgcctcagag     1020

gcctgtgtgg gctccaagtt ctgggagcag agtgtgcggc taggctcctg ggatcgaggg     1080

atgcagtaca gccacagcat catcacgaac ctcctgtacc atgtggtcgg ctggaccgac     1140

tggaaccttg ccctgaaccc cgaaggagga cccaattggg tgcgtaactt tgtcgacagt     1200

cccatcattg tagacatcac caaggacacg ttttacaaac agcccatgtt ctaccacctt     1260

ggccacttca gcaagttcat tcctgagggc tcccagagag tggggctggt tgccagtcag     1320

aagaacgacc tggacgcagt ggcactgatg catcccgatg gctctgctgt tgtggtcgtg     1380

ctaaaccgct cctctaagga tgtgcctctt accatcaagg atcctgctgt gggcttcctg     1440

gagacaatct cacctggcta ctccattcac acctacctgt ggcgtcgcca g              1491


<210>  280
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  GSSG linker

<400>  280
ggctcgagcg gc                                                           12


<210>  281
<211>  510
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  NanoLuc luciferase

<400>  281
gtcttcacac tcgaagattt cgttggggac tggcgacaga cagccggcta caacctggac       60

caagtccttg aacagggagg tgtgtccagt ttgtttcaga atctcggggt gtccgtaact      120

ccgatccaaa ggattgtcct gagcggtgaa aatgggctga agatcgacat ccatgtcatc      180

atcccgtatg aaggtctgag cggcgaccaa atgggccaga tcgaaaaaat ttttaaggtg      240

gtgtaccctg tggatgatca tcactttaag gtgatcctgc actatggcac actggtaatc      300

gacggggtta cgccgaacat gatcgactat ttcggacggc cgtatgaagg catcgccgtg      360

ttcgacggca aaaagatcac tgtaacaggg accctgtgga acggcaacaa aattatcgac      420

gagcgcctga tcaaccccga cggctccctg ctgttccgag taaccatcaa cggagtgacc      480

ggctggcggc tgtgcgaacg cattctggcg                                       510


<210>  282
<211>  3
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Stop codon

<400>  282
taa                                                                      3


<210>  283
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  283
ttacagcggc cgcgactcta gatcataatc agccatacca catttgtaga ggttttactt       60

gctttaaaaa acctcccaca cctccccctg aacctgaaac ataaaatgaa tgcaattgtt      120

gttgtt                                                                 126


<210>  284
<211>  122
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  SV40 polyadenylation signal

<400>  284
aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca       60

aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct      120

ta                                                                     122


<210>  285
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  285
aggcgt                                                                   6


<210>  286
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  F1 ori

<400>  286
aaattgtaag cgttaatatt ttgttaaaat tcgcgttaaa tttttgttaa atcagctcat       60

tttttaacca ataggccgaa atcggcaaaa tcccttataa atcaaaagaa tagaccgaga      120

tagggttgag tgttgttcca gtttggaaca agagtccact attaaagaac gtggactcca      180

acgtcaaagg gcgaaaaacc gtctatcagg gcgatggccc actacgtgaa ccatcaccct      240

aatcaagttt tttggggtcg aggtgccgta aagcactaaa tcggaaccct aaagggagcc      300

cccgatttag agcttgacgg ggaaagccgg cgaacgtggc gagaaaggaa gggaagaaag      360

cgaaaggagc gggcgctagg gcgctggcaa gtgtagcggt cacgctgcgc gtaaccacca      420

cacccgccgc gcttaatgcg ccgctacagg gcgcgt                                456


<210>  287
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  287
caggtggcac ttttcgggga aatgtg                                            26


<210>  288
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  AmpR promoter

<400>  288
cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga       60

caataaccct gataaatgct tcaataatat tgaaaaagga agagt                      105


<210>  289
<211>  358
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  SV40 promoter

<400>  289
ctgaggcgga aagaaccagc tgtggaatgt gtgtcagtta gggtgtggaa agtccccagg       60

ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa ccaggtgtgg      120

aaagtcccca ggctccccag caggcagaag tatgcaaagc atgcatctca attagtcagc      180

aaccatagtc ccgcccctaa ctccgcccat cccgccccta actccgccca gttccgccca      240

ttctccgccc catggctgac taattttttt tatttatgca gaggccgagg ccgcctcggc      300

ctctgagcta ttccagaagt agtgaggagg cttttttgga ggcctaggct tttgcaaa        358


<210>  290
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  290
gatcgatcaa gagacaggat gaggatcgtt tcgc                                   34


<210>  291
<211>  795
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  NeoR/KanR resistance gene

<400>  291
atgattgaac aagatggatt gcacgcaggt tctccggccg cttgggtgga gaggctattc       60

ggctatgact gggcacaaca gacaatcggc tgctctgatg ccgccgtgtt ccggctgtca      120

gcgcaggggc gcccggttct ttttgtcaag accgacctgt ccggtgccct gaatgaactg      180

caagacgagg cagcgcggct atcgtggctg gccacgacgg gcgttccttg cgcagctgtg      240

ctcgacgttg tcactgaagc gggaagggac tggctgctat tgggcgaagt gccggggcag      300

gatctcctgt catctcacct tgctcctgcc gagaaagtat ccatcatggc tgatgcaatg      360

cggcggctgc atacgcttga tccggctacc tgcccattcg accaccaagc gaaacatcgc      420

atcgagcgag cacgtactcg gatggaagcc ggtcttgtcg atcaggatga tctggacgaa      480

gagcatcagg ggctcgcgcc agccgaactg ttcgccaggc tcaaggcgag catgcccgac      540

ggcgaggatc tcgtcgtgac ccatggcgat gcctgcttgc cgaatatcat ggtggaaaat      600

ggccgctttt ctggattcat cgactgtggc cggctgggtg tggcggaccg ctatcaggac      660

atagcgttgg ctacccgtga tattgctgaa gagcttggcg gcgaatgggc tgaccgcttc      720

ctcgtgcttt acggtatcgc cgctcccgat tcgcagcgca tcgccttcta tcgccttctt      780

gacgagttct tctga                                                       795


<210>  292
<211>  231
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  292
gcgggactct ggggttcgaa atgaccgacc aagcgacgcc caacctgcca tcacgagatt       60

tcgattccac cgccgccttc tatgaaaggt tgggcttcgg aatcgttttc cgggacgccg      120

gctggatgat cctccagcgc ggggatctca tgctggagtt cttcgcccac cctaggggga      180

ggctaactga aacacggaag gagacaatac cggaaggaac ccgcgctatg a               231


<210>  293
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  HSV TK polyadenylation signal

<400>  293
cggcaataaa aagacagaat aaaacgcacg gtgttgggtc gtttgttc                    48


<210>  294
<211>  328
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  294
ataaacgcgg ggttcggtcc cagggctggc actctgtcga taccccaccg agaccccatt       60

ggggccaata cgcccgcgtt tcttcctttt ccccacccca ccccccaagt tcgggtgaag      120

gcccagggct cgcagccaac gtcggggcgg caggccctgc catagcctca ggttactcat      180

atatacttta gattgattta aaacttcatt tttaatttaa aaggatctag gtgaagatcc      240

tttttgataa tctcatgacc aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag      300

accccgtaga aaagatcaaa ggatcttc                                         328


<210>  295
<211>  589
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Ori

<400>  295
ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc       60

agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt      120

cagcagagcg cagataccaa atactgtcct tctagtgtag ccgtagttag gccaccactt      180

caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc      240

tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa      300

ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac      360

ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg      420

gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga      480

gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact      540

tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaa                  589


<210>  296
<211>  174
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  296
aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt tgctcacatg       60

ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgccat gcattagtta      120

ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt tccg            174


<210>  297
<211>  304
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CMV enhancer

<400>  297
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catg                                                                   304


<210>  298
<211>  204
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CMV promoter

<400>  298
gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt       60

ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac      120

tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg      180

tgggaggtct atataagcag agct                                             204


<210>  299
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  299
ggtttagtga accgtcagat cc                                                22


<210>  300
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Multiple cloning site (MSC)

<400>  300
gctagcgcta ccggactcag atctcgagct caagcttcga attctgcagt cgacggtacc       60

gcgggcccgg gatccaccgg t                                                 81


<210>  301
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  301
cgccacc                                                                  7


<210>  302
<211>  117
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  GBA signal peptide

<400>  302
atggagtttt caagtccttc cagagaggaa tgtcccaagc ctttgagtag ggtaagcatc       60

atggctggca gcctcacagg attgcttcta cttcaggcag tgtcgtgggc atcaggt         117


<210>  303
<211>  1491
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  GBA mature protein

<400>  303
gcccgcccct gcatccctaa aagcttcggc tacagctcgg tggtgtgtgt ctgcaatgcc       60

acatactgtg actcctttga ccccccgacc tttcctgccc ttggtacctt cagccgctat      120

gagagtacac gcagtgggcg acggatggag ctgagtatgg ggcccatcca ggctaatcac      180

acgggcacag gcctgctact gaccctgcag ccagaacaga agttccagaa agtgaaggga      240

tttggagggg ccatgacaga tgctgctgct ctcaacatcc ttgccctgtc accccctgcc      300

caaaatttgc tacttaaatc gtacttctct gaagaaggaa tcggatataa catcatccgg      360

gtacccatgg ccagctgtga cttctccatc cgcacctaca cctatgcaga cacccctgat      420

gatttccagt tgcacaactt cagcctccca gaggaagata ccaagctcaa gatacccctg      480

attcaccgag ccctgcagtt ggcccagcgt cccgtttcac tccttgccag cccctggaca      540

tcacccactt ggctcaagac caatggagcg gtgaatggga aggggtcact caagggacag      600

cccggagaca tctaccacca gacctgggcc agatactttg tgaagttcct ggatgcctat      660

gctgagcaca agttacagtt ctgggcagtg acagctgaaa atgagccttc tgctgggctg      720

ttgagtggat accccttcca gtgcctgggc ttcacccctg aacatcagcg agacttcatt      780

gcccgtgacc taggtcctac cctcgccaac agtactcacc acaatgtccg cctactcatg      840

ctggatgacc aacgcttgct gctgccccac tgggcaaagg tggtactgac agacccagaa      900

gcagctaaat atgttcatgg cattgctgta cattggtacc tggactttct ggctccagcc      960

aaagccaccc taggggagac acaccgcctg ttccccaaca ccatgctctt tgcctcagag     1020

gcctgtgtgg gctccaagtt ctgggagcag agtgtgcggc taggctcctg ggatcgaggg     1080

atgcagtaca gccacagcat catcacgaac ctcctgtacc atgtggtcgg ctggaccgac     1140

tggaaccttg ccctgaaccc cgaaggagga cccaattggg tgcgtaactt tgtcgacagt     1200

cccatcattg tagacatcac caaggacacg ttttacaaac agcccatgtt ctaccacctt     1260

ggccacttca gcaagttcat tcctgagggc tcccagagag tggggctggt tgccagtcag     1320

aagaacgacc tggacgcagt ggcactgatg catcccgatg gctctgctgt tgtggtcgtg     1380

ctaaaccgct cctctaagga tgtgcctctt accatcaagg atcctgctgt gggcttcctg     1440

gagacaatct cacctggcta ctccattcac acctacctgt ggcgtcgcca g              1491


<210>  304
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  GSSG linker

<400>  304
ggctcgagcg gc                                                           12


<210>  305
<211>  510
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  NanoLuc luciferase

<400>  305
gtcttcacac tcgaagattt cgttggggac tggcgacaga cagccggcta caacctggac       60

caagtccttg aacagggagg tgtgtccagt ttgtttcaga atctcggggt gtccgtaact      120

ccgatccaaa ggattgtcct gagcggtgaa aatgggctga agatcgacat ccatgtcatc      180

atcccgtatg aaggtctgag cggcgaccaa atgggccaga tcgaaaaaat ttttaaggtg      240

gtgtaccctg tggatgatca tcactttaag gtgatcctgc actatggcac actggtaatc      300

gacggggtta cgccgaacat gatcgactat ttcggacggc cgtatgaagg catcgccgtg      360

ttcgacggca aaaagatcac tgtaacaggg accctgtgga acggcaacaa aattatcgac      420

gagcgcctga tcaaccccga cggctccctg ctgttccgag taaccatcaa cggagtgacc      480

ggctggcggc tgtgcgaacg cattctggcg                                       510


<210>  306
<211>  3
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Stop codon

<400>  306
taa                                                                      3


<210>  307
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  307
ttactaatcc ccccccccta                                                   20


<210>  308
<211>  552
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Internal ribosome entry site (IRES) (non-coding)

<400>  308
acgttactgg ccgaagccgc ttggaataag gccggtgtgc gtttgtctat atgttatttt       60

ccaccatatt gccgtctttt ggcaatgtga gggcccggaa acctggccct gtcttcttga      120

cgagcattcc taggggtctt tcccctctcg ccaaaggaat gcaaggtctg ttgaatgtcg      180

tgaaggaagc agttcctctg gaagcttctt gaagacaaac aacgtctgta gcgacccttt      240

gcaggcagcg gaacccccca cctggcgaca ggtgcctctg cggccaaaag ccacgtgtat      300

aagatacacc tgcaaaggcg gcacaacccc agtgccacgt tgtgagttgg atagttgtgg      360

aaagagtcaa atggctctcc tcaagcgtat tcaacaaggg gctgaaggat gcccagaagg      420

taccccattg tatgggatct gatctggggc ctcggtgcac atgctttaca tgtgtttagt      480

cgaggttaaa aaaacgtcta ggccccccga accacgggga cgtggttttc ctttgaaaaa      540

cacgatgata at                                                          552


<210>  309
<211>  201
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Enhancer protein L

<400>  309
atggccacaa ccatggaaca agagacttgc gcgcactctc tcacttttga ggaatgccca       60

aaatgctctg ctctacaata ccgtaatgga ttttacctgc taaagtatga tgaagaatgg      120

tacccagagg agttattgac tgatggagag gatgatgtct ttgatcccga attagacatg      180

gaagtcgttt tcgagttaca g                                                201


<210>  310
<211>  3
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Stop codon

<400>  310
taa                                                                      3


<210>  311
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  311
atcataatca gccataccac atttgtagag gttttacttg ctttaaaaaa cctcccacac       60

ctccccctga acctgaaaca taaaatgaat gcaattgttg ttgtt                      105


<210>  312
<211>  122
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  SV40 polyadenylation signal

<400>  312
aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca       60

aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct      120

ta                                                                     122


<210>  313
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  313
aggcgt                                                                   6


<210>  314
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  F1 ori

<400>  314
aaattgtaag cgttaatatt ttgttaaaat tcgcgttaaa tttttgttaa atcagctcat       60

tttttaacca ataggccgaa atcggcaaaa tcccttataa atcaaaagaa tagaccgaga      120

tagggttgag tgttgttcca gtttggaaca agagtccact attaaagaac gtggactcca      180

acgtcaaagg gcgaaaaacc gtctatcagg gcgatggccc actacgtgaa ccatcaccct      240

aatcaagttt tttggggtcg aggtgccgta aagcactaaa tcggaaccct aaagggagcc      300

cccgatttag agcttgacgg ggaaagccgg cgaacgtggc gagaaaggaa gggaagaaag      360

cgaaaggagc gggcgctagg gcgctggcaa gtgtagcggt cacgctgcgc gtaaccacca      420

cacccgccgc gcttaatgcg ccgctacagg gcgcgt                                456


<210>  315
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  315
caggtggcac ttttcgggga aatgtg                                            26


<210>  316
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  AmpR promoter

<400>  316
cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga       60

caataaccct gataaatgct tcaataatat tgaaaaagga agagt                      105


<210>  317
<211>  358
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  SV40 promoter

<400>  317
ctgaggcgga aagaaccagc tgtggaatgt gtgtcagtta gggtgtggaa agtccccagg       60

ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa ccaggtgtgg      120

aaagtcccca ggctccccag caggcagaag tatgcaaagc atgcatctca attagtcagc      180

aaccatagtc ccgcccctaa ctccgcccat cccgccccta actccgccca gttccgccca      240

ttctccgccc catggctgac taattttttt tatttatgca gaggccgagg ccgcctcggc      300

ctctgagcta ttccagaagt agtgaggagg cttttttgga ggcctaggct tttgcaaa        358


<210>  318
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  318
gatcgatcaa gagacaggat gaggatcgtt tcgc                                   34


<210>  319
<211>  795
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  NeoR/KanR resistance gene

<400>  319
atgattgaac aagatggatt gcacgcaggt tctccggccg cttgggtgga gaggctattc       60

ggctatgact gggcacaaca gacaatcggc tgctctgatg ccgccgtgtt ccggctgtca      120

gcgcaggggc gcccggttct ttttgtcaag accgacctgt ccggtgccct gaatgaactg      180

caagacgagg cagcgcggct atcgtggctg gccacgacgg gcgttccttg cgcagctgtg      240

ctcgacgttg tcactgaagc gggaagggac tggctgctat tgggcgaagt gccggggcag      300

gatctcctgt catctcacct tgctcctgcc gagaaagtat ccatcatggc tgatgcaatg      360

cggcggctgc atacgcttga tccggctacc tgcccattcg accaccaagc gaaacatcgc      420

atcgagcgag cacgtactcg gatggaagcc ggtcttgtcg atcaggatga tctggacgaa      480

gagcatcagg ggctcgcgcc agccgaactg ttcgccaggc tcaaggcgag catgcccgac      540

ggcgaggatc tcgtcgtgac ccatggcgat gcctgcttgc cgaatatcat ggtggaaaat      600

ggccgctttt ctggattcat cgactgtggc cggctgggtg tggcggaccg ctatcaggac      660

atagcgttgg ctacccgtga tattgctgaa gagcttggcg gcgaatgggc tgaccgcttc      720

ctcgtgcttt acggtatcgc cgctcccgat tcgcagcgca tcgccttcta tcgccttctt      780

gacgagttct tctga                                                       795


<210>  320
<211>  231
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  320
gcgggactct ggggttcgaa atgaccgacc aagcgacgcc caacctgcca tcacgagatt       60

tcgattccac cgccgccttc tatgaaaggt tgggcttcgg aatcgttttc cgggacgccg      120

gctggatgat cctccagcgc ggggatctca tgctggagtt cttcgcccac cctaggggga      180

ggctaactga aacacggaag gagacaatac cggaaggaac ccgcgctatg a               231


<210>  321
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  HSV TK polyadenylation signal

<400>  321
cggcaataaa aagacagaat aaaacgcacg gtgttgggtc gtttgttc                    48


<210>  322
<211>  328
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  322
ataaacgcgg ggttcggtcc cagggctggc actctgtcga taccccaccg agaccccatt       60

ggggccaata cgcccgcgtt tcttcctttt ccccacccca ccccccaagt tcgggtgaag      120

gcccagggct cgcagccaac gtcggggcgg caggccctgc catagcctca ggttactcat      180

atatacttta gattgattta aaacttcatt tttaatttaa aaggatctag gtgaagatcc      240

tttttgataa tctcatgacc aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag      300

accccgtaga aaagatcaaa ggatcttc                                         328


<210>  323
<211>  589
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Ori

<400>  323
ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc       60

agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt      120

cagcagagcg cagataccaa atactgtcct tctagtgtag ccgtagttag gccaccactt      180

caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc      240

tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa      300

ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac      360

ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg      420

gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga      480

gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact      540

tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaa                  589


<210>  324
<211>  174
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Linker region

<400>  324
aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt tgctcacatg       60

ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgccat gcattagtta      120

ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt tccg            174


<210>  325
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Albumin signal peptide

<400>  325

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  326
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Adalimumab variable heavy (VH) domain

<400>  326

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  327
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  hIgG1 constant heavy (CH) domain

<400>  327

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  328
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Furin cleavage site

<400>  328

Arg Lys Arg Arg 
1               


<210>  329
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GSG linker

<400>  329

Gly Ser Gly 
1           


<210>  330
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  P2A cleavage site

<400>  330

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  331
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Albumin signal peptide

<400>  331

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  332
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Adalimumab variable light (VL) chain

<400>  332

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  333
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  hIgG kappa constant light (CL) chain

<400>  333

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  334
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Albumin signal peptide

<400>  334

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  335
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Adalimumab variable heavy (VH) domain

<400>  335

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  336
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  hIgG1 constant heavy (CH) domain

<400>  336

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  337
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Furin cleavage site

<400>  337

Arg Lys Arg Arg 
1               


<210>  338
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GSG linker

<400>  338

Gly Ser Gly 
1           


<210>  339
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  P2A cleavage site

<400>  339

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  340
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Albumin signal peptide

<400>  340

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  341
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Adalimumab variable light (VL) chain

<400>  341

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  342
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  hIgG kappa constant light (CL) chain

<400>  342

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  343
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Enhancer protein L

<400>  343

Met Ala Thr Thr Met Glu Gln Glu Thr Cys Ala His Ser Leu Thr Phe 
1               5                   10                  15      


Glu Glu Cys Pro Lys Cys Ser Ala Leu Gln Tyr Arg Asn Gly Phe Tyr 
            20                  25                  30          


Leu Leu Lys Tyr Asp Glu Glu Trp Tyr Pro Glu Glu Leu Leu Thr Asp 
        35                  40                  45              


Gly Glu Asp Asp Val Phe Asp Pro Glu Leu Asp Met Glu Val Val Phe 
    50                  55                  60                  


Glu Leu Gln 
65          


<210>  344
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Albumin signal peptide

<400>  344

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  345
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Adalimumab variable heavy (VH) domain

<400>  345

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  346
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  hIgG1 constant heavy (CH) domain

<400>  346

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  347
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Furin cleavage site

<400>  347

Arg Lys Arg Arg 
1               


<210>  348
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GSG linker

<400>  348

Gly Ser Gly 
1           


<210>  349
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  P2A cleavage site

<400>  349

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  350
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Albumin signal peptide

<400>  350

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  351
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Adalimumab variable light (VL) chain

<400>  351

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  352
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  hIgG kappa constant light (CL) chain

<400>  352

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  353
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Albumin signal peptide

<400>  353

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  354
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Adalimumab variable heavy (VH) domain

<400>  354

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  355
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  hIgG1 constant heavy (CH) domain

<400>  355

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  356
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Furin cleavage site

<400>  356

Arg Lys Arg Arg 
1               


<210>  357
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GSG linker

<400>  357

Gly Ser Gly 
1           


<210>  358
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  P2A cleavage site

<400>  358

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  359
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Albumin signal peptide

<400>  359

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  360
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Adalimumab variable light (VL) chain

<400>  360

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  361
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  hIgG kappa constant light (CL) chain

<400>  361

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  362
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Enhancer protein L

<400>  362

Met Ala Thr Thr Met Glu Gln Glu Thr Cys Ala His Ser Leu Thr Phe 
1               5                   10                  15      


Glu Glu Cys Pro Lys Cys Ser Ala Leu Gln Tyr Arg Asn Gly Phe Tyr 
            20                  25                  30          


Leu Leu Lys Tyr Asp Glu Glu Trp Tyr Pro Glu Glu Leu Leu Thr Asp 
        35                  40                  45              


Gly Glu Asp Asp Val Phe Asp Pro Glu Leu Asp Met Glu Val Val Phe 
    50                  55                  60                  


Glu Leu Gln 
65          


<210>  363
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GBA signal peptide

<400>  363

Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys Pro Lys Pro Leu Ser 
1               5                   10                  15      


Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly Leu Leu Leu Leu Gln 
            20                  25                  30          


Ala Val Ser Trp Ala Ser Gly 
        35                  


<210>  364
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Mature GBA protein

<400>  364

Ala Arg Pro Cys Ile Pro Lys Ser Phe Gly Tyr Ser Ser Val Val Cys 
1               5                   10                  15      


Val Cys Asn Ala Thr Tyr Cys Asp Ser Phe Asp Pro Pro Thr Phe Pro 
            20                  25                  30          


Ala Leu Gly Thr Phe Ser Arg Tyr Glu Ser Thr Arg Ser Gly Arg Arg 
        35                  40                  45              


Met Glu Leu Ser Met Gly Pro Ile Gln Ala Asn His Thr Gly Thr Gly 
    50                  55                  60                  


Leu Leu Leu Thr Leu Gln Pro Glu Gln Lys Phe Gln Lys Val Lys Gly 
65                  70                  75                  80  


Phe Gly Gly Ala Met Thr Asp Ala Ala Ala Leu Asn Ile Leu Ala Leu 
                85                  90                  95      


Ser Pro Pro Ala Gln Asn Leu Leu Leu Lys Ser Tyr Phe Ser Glu Glu 
            100                 105                 110         


Gly Ile Gly Tyr Asn Ile Ile Arg Val Pro Met Ala Ser Cys Asp Phe 
        115                 120                 125             


Ser Ile Arg Thr Tyr Thr Tyr Ala Asp Thr Pro Asp Asp Phe Gln Leu 
    130                 135                 140                 


His Asn Phe Ser Leu Pro Glu Glu Asp Thr Lys Leu Lys Ile Pro Leu 
145                 150                 155                 160 


Ile His Arg Ala Leu Gln Leu Ala Gln Arg Pro Val Ser Leu Leu Ala 
                165                 170                 175     


Ser Pro Trp Thr Ser Pro Thr Trp Leu Lys Thr Asn Gly Ala Val Asn 
            180                 185                 190         


Gly Lys Gly Ser Leu Lys Gly Gln Pro Gly Asp Ile Tyr His Gln Thr 
        195                 200                 205             


Trp Ala Arg Tyr Phe Val Lys Phe Leu Asp Ala Tyr Ala Glu His Lys 
    210                 215                 220                 


Leu Gln Phe Trp Ala Val Thr Ala Glu Asn Glu Pro Ser Ala Gly Leu 
225                 230                 235                 240 


Leu Ser Gly Tyr Pro Phe Gln Cys Leu Gly Phe Thr Pro Glu His Gln 
                245                 250                 255     


Arg Asp Phe Ile Ala Arg Asp Leu Gly Pro Thr Leu Ala Asn Ser Thr 
            260                 265                 270         


His His Asn Val Arg Leu Leu Met Leu Asp Asp Gln Arg Leu Leu Leu 
        275                 280                 285             


Pro His Trp Ala Lys Val Val Leu Thr Asp Pro Glu Ala Ala Lys Tyr 
    290                 295                 300                 


Val His Gly Ile Ala Val His Trp Tyr Leu Asp Phe Leu Ala Pro Ala 
305                 310                 315                 320 


Lys Ala Thr Leu Gly Glu Thr His Arg Leu Phe Pro Asn Thr Met Leu 
                325                 330                 335     


Phe Ala Ser Glu Ala Cys Val Gly Ser Lys Phe Trp Glu Gln Ser Val 
            340                 345                 350         


Arg Leu Gly Ser Trp Asp Arg Gly Met Gln Tyr Ser His Ser Ile Ile 
        355                 360                 365             


Thr Asn Leu Leu Tyr His Val Val Gly Trp Thr Asp Trp Asn Leu Ala 
    370                 375                 380                 


Leu Asn Pro Glu Gly Gly Pro Asn Trp Val Arg Asn Phe Val Asp Ser 
385                 390                 395                 400 


Pro Ile Ile Val Asp Ile Thr Lys Asp Thr Phe Tyr Lys Gln Pro Met 
                405                 410                 415     


Phe Tyr His Leu Gly His Phe Ser Lys Phe Ile Pro Glu Gly Ser Gln 
            420                 425                 430         


Arg Val Gly Leu Val Ala Ser Gln Lys Asn Asp Leu Asp Ala Val Ala 
        435                 440                 445             


Leu Met His Pro Asp Gly Ser Ala Val Val Val Val Leu Asn Arg Ser 
    450                 455                 460                 


Ser Lys Asp Val Pro Leu Thr Ile Lys Asp Pro Ala Val Gly Phe Leu 
465                 470                 475                 480 


Glu Thr Ile Ser Pro Gly Tyr Ser Ile His Thr Tyr Leu Trp Arg Arg 
                485                 490                 495     


Gln 
    


<210>  365
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GSSG linker

<400>  365

Gly Ser Ser Gly 
1               


<210>  366
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NanoLuc luciferase

<400>  366

Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln Thr Ala Gly 
1               5                   10                  15      


Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu Phe 
            20                  25                  30          


Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile Val Leu Ser 
        35                  40                  45              


Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr Glu 
    50                  55                  60                  


Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile Phe Lys Val 
65                  70                  75                  80  


Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu His Tyr Gly 
                85                  90                  95      


Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp Tyr Phe Gly 
            100                 105                 110         


Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr Val 
        115                 120                 125             


Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile 
    130                 135                 140                 


Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn Gly Val Thr 
145                 150                 155                 160 


Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala 
                165                 170 


<210>  367
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NeoR/KanR resistance gene

<400>  367

Met Ile Glu Gln Asp Gly Leu His Ala Gly Ser Pro Ala Ala Trp Val 
1               5                   10                  15      


Glu Arg Leu Phe Gly Tyr Asp Trp Ala Gln Gln Thr Ile Gly Cys Ser 
            20                  25                  30          


Asp Ala Ala Val Phe Arg Leu Ser Ala Gln Gly Arg Pro Val Leu Phe 
        35                  40                  45              


Val Lys Thr Asp Leu Ser Gly Ala Leu Asn Glu Leu Gln Asp Glu Ala 
    50                  55                  60                  


Ala Arg Leu Ser Trp Leu Ala Thr Thr Gly Val Pro Cys Ala Ala Val 
65                  70                  75                  80  


Leu Asp Val Val Thr Glu Ala Gly Arg Asp Trp Leu Leu Leu Gly Glu 
                85                  90                  95      


Val Pro Gly Gln Asp Leu Leu Ser Ser His Leu Ala Pro Ala Glu Lys 
            100                 105                 110         


Val Ser Ile Met Ala Asp Ala Met Arg Arg Leu His Thr Leu Asp Pro 
        115                 120                 125             


Ala Thr Cys Pro Phe Asp His Gln Ala Lys His Arg Ile Glu Arg Ala 
    130                 135                 140                 


Arg Thr Arg Met Glu Ala Gly Leu Val Asp Gln Asp Asp Leu Asp Glu 
145                 150                 155                 160 


Glu His Gln Gly Leu Ala Pro Ala Glu Leu Phe Ala Arg Leu Lys Ala 
                165                 170                 175     


Ser Met Pro Asp Gly Glu Asp Leu Val Val Thr His Gly Asp Ala Cys 
            180                 185                 190         


Leu Pro Asn Ile Met Val Glu Asn Gly Arg Phe Ser Gly Phe Ile Asp 
        195                 200                 205             


Cys Gly Arg Leu Gly Val Ala Asp Arg Tyr Gln Asp Ile Ala Leu Ala 
    210                 215                 220                 


Thr Arg Asp Ile Ala Glu Glu Leu Gly Gly Glu Trp Ala Asp Arg Phe 
225                 230                 235                 240 


Leu Val Leu Tyr Gly Ile Ala Ala Pro Asp Ser Gln Arg Ile Ala Phe 
                245                 250                 255     


Tyr Arg Leu Leu Asp Glu Phe Phe 
            260                 


<210>  368
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GBA signal peptide

<400>  368

Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys Pro Lys Pro Leu Ser 
1               5                   10                  15      


Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly Leu Leu Leu Leu Gln 
            20                  25                  30          


Ala Val Ser Trp Ala Ser Gly 
        35                  


<210>  369
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Mature GBA protein

<400>  369

Ala Arg Pro Cys Ile Pro Lys Ser Phe Gly Tyr Ser Ser Val Val Cys 
1               5                   10                  15      


Val Cys Asn Ala Thr Tyr Cys Asp Ser Phe Asp Pro Pro Thr Phe Pro 
            20                  25                  30          


Ala Leu Gly Thr Phe Ser Arg Tyr Glu Ser Thr Arg Ser Gly Arg Arg 
        35                  40                  45              


Met Glu Leu Ser Met Gly Pro Ile Gln Ala Asn His Thr Gly Thr Gly 
    50                  55                  60                  


Leu Leu Leu Thr Leu Gln Pro Glu Gln Lys Phe Gln Lys Val Lys Gly 
65                  70                  75                  80  


Phe Gly Gly Ala Met Thr Asp Ala Ala Ala Leu Asn Ile Leu Ala Leu 
                85                  90                  95      


Ser Pro Pro Ala Gln Asn Leu Leu Leu Lys Ser Tyr Phe Ser Glu Glu 
            100                 105                 110         


Gly Ile Gly Tyr Asn Ile Ile Arg Val Pro Met Ala Ser Cys Asp Phe 
        115                 120                 125             


Ser Ile Arg Thr Tyr Thr Tyr Ala Asp Thr Pro Asp Asp Phe Gln Leu 
    130                 135                 140                 


His Asn Phe Ser Leu Pro Glu Glu Asp Thr Lys Leu Lys Ile Pro Leu 
145                 150                 155                 160 


Ile His Arg Ala Leu Gln Leu Ala Gln Arg Pro Val Ser Leu Leu Ala 
                165                 170                 175     


Ser Pro Trp Thr Ser Pro Thr Trp Leu Lys Thr Asn Gly Ala Val Asn 
            180                 185                 190         


Gly Lys Gly Ser Leu Lys Gly Gln Pro Gly Asp Ile Tyr His Gln Thr 
        195                 200                 205             


Trp Ala Arg Tyr Phe Val Lys Phe Leu Asp Ala Tyr Ala Glu His Lys 
    210                 215                 220                 


Leu Gln Phe Trp Ala Val Thr Ala Glu Asn Glu Pro Ser Ala Gly Leu 
225                 230                 235                 240 


Leu Ser Gly Tyr Pro Phe Gln Cys Leu Gly Phe Thr Pro Glu His Gln 
                245                 250                 255     


Arg Asp Phe Ile Ala Arg Asp Leu Gly Pro Thr Leu Ala Asn Ser Thr 
            260                 265                 270         


His His Asn Val Arg Leu Leu Met Leu Asp Asp Gln Arg Leu Leu Leu 
        275                 280                 285             


Pro His Trp Ala Lys Val Val Leu Thr Asp Pro Glu Ala Ala Lys Tyr 
    290                 295                 300                 


Val His Gly Ile Ala Val His Trp Tyr Leu Asp Phe Leu Ala Pro Ala 
305                 310                 315                 320 


Lys Ala Thr Leu Gly Glu Thr His Arg Leu Phe Pro Asn Thr Met Leu 
                325                 330                 335     


Phe Ala Ser Glu Ala Cys Val Gly Ser Lys Phe Trp Glu Gln Ser Val 
            340                 345                 350         


Arg Leu Gly Ser Trp Asp Arg Gly Met Gln Tyr Ser His Ser Ile Ile 
        355                 360                 365             


Thr Asn Leu Leu Tyr His Val Val Gly Trp Thr Asp Trp Asn Leu Ala 
    370                 375                 380                 


Leu Asn Pro Glu Gly Gly Pro Asn Trp Val Arg Asn Phe Val Asp Ser 
385                 390                 395                 400 


Pro Ile Ile Val Asp Ile Thr Lys Asp Thr Phe Tyr Lys Gln Pro Met 
                405                 410                 415     


Phe Tyr His Leu Gly His Phe Ser Lys Phe Ile Pro Glu Gly Ser Gln 
            420                 425                 430         


Arg Val Gly Leu Val Ala Ser Gln Lys Asn Asp Leu Asp Ala Val Ala 
        435                 440                 445             


Leu Met His Pro Asp Gly Ser Ala Val Val Val Val Leu Asn Arg Ser 
    450                 455                 460                 


Ser Lys Asp Val Pro Leu Thr Ile Lys Asp Pro Ala Val Gly Phe Leu 
465                 470                 475                 480 


Glu Thr Ile Ser Pro Gly Tyr Ser Ile His Thr Tyr Leu Trp Arg Arg 
                485                 490                 495     


Gln 
    


<210>  370
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GSSG linker

<400>  370

Gly Ser Ser Gly 
1               


<210>  371
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NanoLuc luciferase

<400>  371

Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln Thr Ala Gly 
1               5                   10                  15      


Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu Phe 
            20                  25                  30          


Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile Val Leu Ser 
        35                  40                  45              


Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr Glu 
    50                  55                  60                  


Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile Phe Lys Val 
65                  70                  75                  80  


Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu His Tyr Gly 
                85                  90                  95      


Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp Tyr Phe Gly 
            100                 105                 110         


Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr Val 
        115                 120                 125             


Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile 
    130                 135                 140                 


Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn Gly Val Thr 
145                 150                 155                 160 


Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala 
                165                 170 


<210>  372
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Enhancer protein L

<400>  372

Met Ala Thr Thr Met Glu Gln Glu Thr Cys Ala His Ser Leu Thr Phe 
1               5                   10                  15      


Glu Glu Cys Pro Lys Cys Ser Ala Leu Gln Tyr Arg Asn Gly Phe Tyr 
            20                  25                  30          


Leu Leu Lys Tyr Asp Glu Glu Trp Tyr Pro Glu Glu Leu Leu Thr Asp 
        35                  40                  45              


Gly Glu Asp Asp Val Phe Asp Pro Glu Leu Asp Met Glu Val Val Phe 
    50                  55                  60                  


Glu Leu Gln 
65          


<210>  373
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  NeoR/KanR resistance gene

<400>  373

Met Ile Glu Gln Asp Gly Leu His Ala Gly Ser Pro Ala Ala Trp Val 
1               5                   10                  15      


Glu Arg Leu Phe Gly Tyr Asp Trp Ala Gln Gln Thr Ile Gly Cys Ser 
            20                  25                  30          


Asp Ala Ala Val Phe Arg Leu Ser Ala Gln Gly Arg Pro Val Leu Phe 
        35                  40                  45              


Val Lys Thr Asp Leu Ser Gly Ala Leu Asn Glu Leu Gln Asp Glu Ala 
    50                  55                  60                  


Ala Arg Leu Ser Trp Leu Ala Thr Thr Gly Val Pro Cys Ala Ala Val 
65                  70                  75                  80  


Leu Asp Val Val Thr Glu Ala Gly Arg Asp Trp Leu Leu Leu Gly Glu 
                85                  90                  95      


Val Pro Gly Gln Asp Leu Leu Ser Ser His Leu Ala Pro Ala Glu Lys 
            100                 105                 110         


Val Ser Ile Met Ala Asp Ala Met Arg Arg Leu His Thr Leu Asp Pro 
        115                 120                 125             


Ala Thr Cys Pro Phe Asp His Gln Ala Lys His Arg Ile Glu Arg Ala 
    130                 135                 140                 


Arg Thr Arg Met Glu Ala Gly Leu Val Asp Gln Asp Asp Leu Asp Glu 
145                 150                 155                 160 


Glu His Gln Gly Leu Ala Pro Ala Glu Leu Phe Ala Arg Leu Lys Ala 
                165                 170                 175     


Ser Met Pro Asp Gly Glu Asp Leu Val Val Thr His Gly Asp Ala Cys 
            180                 185                 190         


Leu Pro Asn Ile Met Val Glu Asn Gly Arg Phe Ser Gly Phe Ile Asp 
        195                 200                 205             


Cys Gly Arg Leu Gly Val Ala Asp Arg Tyr Gln Asp Ile Ala Leu Ala 
    210                 215                 220                 


Thr Arg Asp Ile Ala Glu Glu Leu Gly Gly Glu Trp Ala Asp Arg Phe 
225                 230                 235                 240 


Leu Val Leu Tyr Gly Ile Ala Ala Pro Asp Ser Gln Arg Ile Ala Phe 
                245                 250                 255     


Tyr Arg Leu Leu Asp Glu Phe Phe 
            260                 


<210>  374
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Pembrolizumab VH

<400>  374

Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  375
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Pembrolizumab VL

<400>  375

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  376
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Nivolumab VH

<400>  376

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  377
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Nivolumab VL

<400>  377

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  378
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Trastuzumab VH

<400>  378

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  379
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Trastuzumab VL

<400>  379

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  380
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Bevacizumab VH

<400>  380

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Pro His Tyr Tyr Gly Ser Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  381
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Bevacizumab VL

<400>  381

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  382
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ustekinumab VH

<400>  382

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Thr Tyr 
            20                  25                  30          


Trp Leu Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Ile Met Ser Pro Val Asp Ser Asp Ile Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Met Ser Val Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Pro Gly Gln Gly Tyr Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  383
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ustekinumab VL

<400>  383

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  384
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ocrelizumab VH

<400>  384

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  385
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ocrelizumab VL

<400>  385

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile Tyr 
        35                  40                  45              


Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  386
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Secukinumab VH

<400>  386

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Tyr Tyr Asp Ile Leu Thr Asp Tyr Tyr Ile His Tyr Trp 
            100                 105                 110         


Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  387
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Secukinumab VL

<400>  387

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Cys Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  388
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Vedolizumab VH

<400>  388

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Pro Ser Glu Ser Asn Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Val Asp Ile Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Asp Gly Trp Asp Tyr Ala Ile Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  389
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Vedolizumab VL

<400>  389

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Ala Lys Ser 
            20                  25                  30          


Tyr Gly Asn Thr Tyr Leu Ser Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gly Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Gly 
                85                  90                  95      


Thr His Gln Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  390
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ibalizumab VH

<400>  390

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Asp Tyr Asp Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Asp Asn Tyr Ala Thr Gly Ala Trp Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  391
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Ibalizumab VL

<400>  391

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Thr Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  392
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Nirsevimab VH

<400>  392

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Met Val Ser Cys Gln Ala Ser Gly Gly Leu Leu Glu Asp Tyr 
            20                  25                  30          


Ile Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Val Leu Gly Thr Val His Tyr Gly Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Glu Thr Ala Leu Val Val Ser Glu Thr Tyr Leu Pro His Tyr 
            100                 105                 110         


Phe Asp Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  393
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Nirsevimab VL

<400>  393

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ala Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Val Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  394
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Atoltivimab VH

<400>  394

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Met Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp His Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Trp Asn Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  395
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Atoltivimab VL

<400>  395

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Phe Ser Thr Pro Pro 
                85                  90                  95      


Ile Asn Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  396
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Maftivimab VH

<400>  396

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Ser Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Met Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Gly Tyr Pro His Ser Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  397
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Maftivimab VL

<400>  397

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Leu Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105     


<210>  398
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Odesivimab VH

<400>  398

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Thr Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Thr Ala Gly Asp Thr Tyr Tyr Pro Gly Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Trp Phe Gly Glu Leu Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  399
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Odesivimab VL

<400>  399

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Thr Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Ser Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  400
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Casirivimab VH

<400>  400

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Thr Tyr Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Thr Thr Met Val Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  401
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Casirivimab VL

<400>  401

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Thr Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  402
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Imdevimab VH

<400>  402

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Ser Asp Tyr Gly Asp Tyr Leu Leu Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  403
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Imdevimab VL

<400>  403

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Leu Thr Ser Ile 
                85                  90                  95      


Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  404
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Brolucizumab VH

<400>  404

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Leu Thr Asp Tyr 
            20                  25                  30          


Tyr Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Gly Phe Ile Asp Pro Asp Asp Asp Pro Tyr Tyr Ala Thr Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Gly Asp His Asn Ser Gly Trp Gly Leu Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  405
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Brolucizumab VL

<400>  405

Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ile Ile Thr Cys Gln Ala Ser Glu Ile Ile His Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Tyr Leu Ala Ser Thr 
                85                  90                  95      


Asn Gly Ala Asn Phe Gly Gln Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  406
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Glucosylceramidase (GBA)

<400>  406

Ala Arg Pro Cys Ile Pro Lys Ser Phe Gly Tyr Ser Ser Val Val Cys 
1               5                   10                  15      


Val Cys Asn Ala Thr Tyr Cys Asp Ser Phe Asp Pro Pro Thr Phe Pro 
            20                  25                  30          


Ala Leu Gly Thr Phe Ser Arg Tyr Glu Ser Thr Arg Ser Gly Arg Arg 
        35                  40                  45              


Met Glu Leu Ser Met Gly Pro Ile Gln Ala Asn His Thr Gly Thr Gly 
    50                  55                  60                  


Leu Leu Leu Thr Leu Gln Pro Glu Gln Lys Phe Gln Lys Val Lys Gly 
65                  70                  75                  80  


Phe Gly Gly Ala Met Thr Asp Ala Ala Ala Leu Asn Ile Leu Ala Leu 
                85                  90                  95      


Ser Pro Pro Ala Gln Asn Leu Leu Leu Lys Ser Tyr Phe Ser Glu Glu 
            100                 105                 110         


Gly Ile Gly Tyr Asn Ile Ile Arg Val Pro Met Ala Ser Cys Asp Phe 
        115                 120                 125             


Ser Ile Arg Thr Tyr Thr Tyr Ala Asp Thr Pro Asp Asp Phe Gln Leu 
    130                 135                 140                 


His Asn Phe Ser Leu Pro Glu Glu Asp Thr Lys Leu Lys Ile Pro Leu 
145                 150                 155                 160 


Ile His Arg Ala Leu Gln Leu Ala Gln Arg Pro Val Ser Leu Leu Ala 
                165                 170                 175     


Ser Pro Trp Thr Ser Pro Thr Trp Leu Lys Thr Asn Gly Ala Val Asn 
            180                 185                 190         


Gly Lys Gly Ser Leu Lys Gly Gln Pro Gly Asp Ile Tyr His Gln Thr 
        195                 200                 205             


Trp Ala Arg Tyr Phe Val Lys Phe Leu Asp Ala Tyr Ala Glu His Lys 
    210                 215                 220                 


Leu Gln Phe Trp Ala Val Thr Ala Glu Asn Glu Pro Ser Ala Gly Leu 
225                 230                 235                 240 


Leu Ser Gly Tyr Pro Phe Gln Cys Leu Gly Phe Thr Pro Glu His Gln 
                245                 250                 255     


Arg Asp Phe Ile Ala Arg Asp Leu Gly Pro Thr Leu Ala Asn Ser Thr 
            260                 265                 270         


His His Asn Val Arg Leu Leu Met Leu Asp Asp Gln Arg Leu Leu Leu 
        275                 280                 285             


Pro His Trp Ala Lys Val Val Leu Thr Asp Pro Glu Ala Ala Lys Tyr 
    290                 295                 300                 


Val His Gly Ile Ala Val His Trp Tyr Leu Asp Phe Leu Ala Pro Ala 
305                 310                 315                 320 


Lys Ala Thr Leu Gly Glu Thr His Arg Leu Phe Pro Asn Thr Met Leu 
                325                 330                 335     


Phe Ala Ser Glu Ala Cys Val Gly Ser Lys Phe Trp Glu Gln Ser Val 
            340                 345                 350         


Arg Leu Gly Ser Trp Asp Arg Gly Met Gln Tyr Ser His Ser Ile Ile 
        355                 360                 365             


Thr Asn Leu Leu Tyr His Val Val Gly Trp Thr Asp Trp Asn Leu Ala 
    370                 375                 380                 


Leu Asn Pro Glu Gly Gly Pro Asn Trp Val Arg Asn Phe Val Asp Ser 
385                 390                 395                 400 


Pro Ile Ile Val Asp Ile Thr Lys Asp Thr Phe Tyr Lys Gln Pro Met 
                405                 410                 415     


Phe Tyr His Leu Gly His Phe Ser Lys Phe Ile Pro Glu Gly Ser Gln 
            420                 425                 430         


Arg Val Gly Leu Val Ala Ser Gln Lys Asn Asp Leu Asp Ala Val Ala 
        435                 440                 445             


Leu Met His Pro Asp Gly Ser Ala Val Val Val Val Leu Asn Arg Ser 
    450                 455                 460                 


Ser Lys Asp Val Pro Leu Thr Ile Lys Asp Pro Ala Val Gly Phe Leu 
465                 470                 475                 480 


Glu Thr Ile Ser Pro Gly Tyr Ser Ile His Thr Tyr Leu Trp Arg Arg 
                485                 490                 495     


Gln 
    


<210>  407
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  rFIX-Fc Coagulation Factor IX

<400>  407

Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg 
1               5                   10                  15      


Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe 
            20                  25                  30          


Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly 
        35                  40                  45              


Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp 
    50                  55                  60                  


Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys 
65                  70                  75                  80  


Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu 
                85                  90                  95      


Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr 
            100                 105                 110         


Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val 
        115                 120                 125             


Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr 
    130                 135                 140                 


Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu 
145                 150                 155                 160 


Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn 
                165                 170                 175     


Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe 
            180                 185                 190         


Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly 
        195                 200                 205             


Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu 
    210                 215                 220                 


Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu 
225                 230                 235                 240 


Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His 
                245                 250                 255     


His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu 
            260                 265                 270         


Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile 
        275                 280                 285             


Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser 
    290                 295                 300                 


Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala 
305                 310                 315                 320 


Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys 
                325                 330                 335     


Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly 
            340                 345                 350         


Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 
        355                 360                 365             


His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser 
    370                 375                 380                 


Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 
385                 390                 395                 400 


Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
                405                 410                 415 


<210>  408
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Taliglucerase

<400>  408

Glu Phe Ala Arg Pro Cys Ile Pro Lys Ser Phe Gly Tyr Ser Ser Val 
1               5                   10                  15      


Val Cys Val Cys Asn Ala Thr Tyr Cys Asp Ser Phe Asp Pro Pro Thr 
            20                  25                  30          


Phe Pro Ala Leu Gly Thr Phe Ser Arg Tyr Glu Ser Thr Arg Ser Gly 
        35                  40                  45              


Arg Arg Met Glu Leu Ser Met Gly Pro Ile Gln Ala Asn His Thr Gly 
    50                  55                  60                  


Thr Gly Leu Leu Leu Thr Leu Gln Pro Glu Gln Lys Phe Gln Lys Val 
65                  70                  75                  80  


Lys Gly Phe Gly Gly Ala Met Thr Asp Ala Ala Ala Leu Asn Ile Leu 
                85                  90                  95      


Ala Leu Ser Pro Pro Ala Gln Asn Leu Leu Leu Lys Ser Tyr Phe Ser 
            100                 105                 110         


Glu Glu Gly Ile Gly Tyr Asn Ile Ile Arg Val Pro Met Ala Ser Cys 
        115                 120                 125             


Asp Phe Ser Ile Arg Thr Tyr Thr Tyr Ala Asp Thr Pro Asp Asp Phe 
    130                 135                 140                 


Gln Leu His Asn Phe Ser Leu Pro Glu Glu Asp Thr Lys Leu Lys Ile 
145                 150                 155                 160 


Pro Leu Ile His Arg Ala Leu Gln Leu Ala Gln Arg Pro Val Ser Leu 
                165                 170                 175     


Leu Ala Ser Pro Trp Thr Ser Pro Thr Trp Leu Lys Thr Asn Gly Ala 
            180                 185                 190         


Val Asn Gly Lys Gly Ser Leu Lys Gly Gln Pro Gly Asp Ile Tyr His 
        195                 200                 205             


Gln Thr Trp Ala Arg Tyr Phe Val Lys Phe Leu Asp Ala Tyr Ala Glu 
    210                 215                 220                 


His Lys Leu Gln Phe Trp Ala Val Thr Ala Glu Asn Glu Pro Ser Ala 
225                 230                 235                 240 


Gly Leu Leu Ser Gly Tyr Pro Phe Gln Cys Leu Gly Phe Thr Pro Glu 
                245                 250                 255     


His Gln Arg Asp Phe Ile Ala Arg Asp Leu Gly Pro Thr Leu Ala Asn 
            260                 265                 270         


Ser Thr His His Asn Val Arg Leu Leu Met Leu Asp Asp Gln Arg Leu 
        275                 280                 285             


Leu Leu Pro His Trp Ala Lys Val Val Leu Thr Asp Pro Glu Ala Ala 
    290                 295                 300                 


Lys Tyr Val His Gly Ile Ala Val His Trp Tyr Leu Asp Phe Leu Ala 
305                 310                 315                 320 


Pro Ala Lys Ala Thr Leu Gly Glu Thr His Arg Leu Phe Pro Asn Thr 
                325                 330                 335     


Met Leu Phe Ala Ser Glu Ala Cys Val Gly Ser Lys Phe Trp Glu Gln 
            340                 345                 350         


Ser Val Arg Leu Gly Ser Trp Asp Arg Gly Met Gln Tyr Ser His Ser 
        355                 360                 365             


Ile Ile Thr Asn Leu Leu Tyr His Val Val Gly Trp Thr Asp Trp Asn 
    370                 375                 380                 


Leu Ala Leu Asn Pro Glu Gly Gly Pro Asn Trp Val Arg Asn Phe Val 
385                 390                 395                 400 


Asp Ser Pro Ile Ile Val Asp Ile Thr Lys Asp Thr Phe Tyr Lys Gln 
                405                 410                 415     


Pro Met Phe Tyr His Leu Gly His Phe Ser Lys Phe Ile Pro Glu Gly 
            420                 425                 430         


Ser Gln Arg Val Gly Leu Val Ala Ser Gln Lys Asn Asp Leu Asp Ala 
        435                 440                 445             


Val Ala Leu Met His Pro Asp Gly Ser Ala Val Val Val Val Leu Asn 
    450                 455                 460                 


Arg Ser Ser Lys Asp Val Pro Leu Thr Ile Lys Asp Pro Ala Val Gly 
465                 470                 475                 480 


Phe Leu Glu Thr Ile Ser Pro Gly Tyr Ser Ile His Thr Tyr Leu Trp 
                485                 490                 495     


His Arg Gln Asp Leu Leu Val Asp Thr Met 
            500                 505     


<210>  409
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Agalsidase beta

<400>  409

Leu Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp 
1               5                   10                  15      


Glu Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys 
            20                  25                  30          


Ile Ser Glu Lys Leu Phe Met Glu Met Ala Glu Leu Met Val Ser Glu 
        35                  40                  45              


Gly Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp 
    50                  55                  60                  


Met Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln 
65                  70                  75                  80  


Arg Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys 
                85                  90                  95      


Gly Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala 
            100                 105                 110         


Gly Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe 
        115                 120                 125             


Ala Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp 
    130                 135                 140                 


Ser Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu 
145                 150                 155                 160 


Asn Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr 
                165                 170                 175     


Met Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys 
            180                 185                 190         


Asn His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Lys Ser Ile 
        195                 200                 205             


Lys Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln Glu Arg Ile Val Asp 
    210                 215                 220                 


Val Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly 
225                 230                 235                 240 


Asn Phe Gly Leu Ser Trp Asn Gln Gln Val Thr Gln Met Ala Leu Trp 
                245                 250                 255     


Ala Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile 
            260                 265                 270         


Ser Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile 
        275                 280                 285             


Asn Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Gln Gly Asp 
    290                 295                 300                 


Asn Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Leu Ala Trp Ala Val 
305                 310                 315                 320 


Ala Met Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile 
                325                 330                 335     


Ala Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe 
            340                 345                 350         


Ile Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Trp 
        355                 360                 365             


Thr Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu 
    370                 375                 380                 


Gln Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
385                 390                 395             


<210>  410
<211>  626
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Laronidase

<400>  410

Ala Pro His Leu Val Gln Val Asp Ala Ala Arg Ala Leu Trp Pro Leu 
1               5                   10                  15      


Arg Arg Phe Trp Arg Ser Thr Gly Phe Cys Pro Pro Leu Pro His Ser 
            20                  25                  30          


Gln Ala Asp Gln Tyr Val Leu Ser Trp Asp Gln Gln Leu Asn Leu Ala 
        35                  40                  45              


Tyr Val Gly Ala Val Pro His Arg Gly Ile Lys Gln Val Arg Thr His 
    50                  55                  60                  


Trp Leu Leu Glu Leu Val Thr Thr Arg Gly Ser Thr Gly Arg Gly Leu 
65                  70                  75                  80  


Ser Tyr Asn Phe Thr His Leu Asp Gly Tyr Leu Asp Leu Leu Arg Glu 
                85                  90                  95      


Asn Gln Leu Leu Pro Gly Phe Glu Leu Met Gly Ser Ala Ser Gly His 
            100                 105                 110         


Phe Thr Asp Phe Glu Asp Lys Gln Gln Val Phe Glu Trp Lys Asp Leu 
        115                 120                 125             


Val Ser Ser Leu Ala Arg Arg Tyr Ile Gly Arg Tyr Gly Leu Ala His 
    130                 135                 140                 


Val Ser Lys Trp Asn Phe Glu Thr Trp Asn Glu Pro Asp His His Asp 
145                 150                 155                 160 


Phe Asp Asn Val Ser Met Thr Met Gln Gly Phe Leu Asn Tyr Tyr Asp 
                165                 170                 175     


Ala Cys Ser Glu Gly Leu Arg Ala Ala Ser Pro Ala Leu Arg Leu Gly 
            180                 185                 190         


Gly Pro Gly Asp Ser Phe His Thr Pro Pro Arg Ser Pro Leu Ser Trp 
        195                 200                 205             


Gly Leu Leu Arg His Cys His Asp Gly Thr Asn Phe Phe Thr Gly Glu 
    210                 215                 220                 


Ala Gly Val Arg Leu Asp Tyr Ile Ser Leu His Arg Lys Gly Ala Arg 
225                 230                 235                 240 


Ser Ser Ile Ser Ile Leu Glu Gln Glu Lys Val Val Ala Gln Gln Ile 
                245                 250                 255     


Arg Gln Leu Phe Pro Lys Phe Ala Asp Thr Pro Ile Tyr Asn Asp Glu 
            260                 265                 270         


Ala Asp Pro Leu Val Gly Trp Ser Leu Pro Gln Pro Trp Arg Ala Asp 
        275                 280                 285             


Val Thr Tyr Ala Ala Met Val Val Lys Val Ile Ala Gln His Gln Asn 
    290                 295                 300                 


Leu Leu Leu Ala Asn Thr Thr Ser Ala Phe Pro Tyr Ala Leu Leu Ser 
305                 310                 315                 320 


Asn Asp Asn Ala Phe Leu Ser Tyr His Pro His Pro Phe Ala Gln Arg 
                325                 330                 335     


Thr Leu Thr Ala Arg Phe Gln Val Asn Asn Thr Arg Pro Pro His Val 
            340                 345                 350         


Gln Leu Leu Arg Lys Pro Val Leu Thr Ala Met Gly Leu Leu Ala Leu 
        355                 360                 365             


Leu Asp Glu Glu Gln Leu Trp Ala Glu Val Ser Gln Ala Gly Thr Val 
    370                 375                 380                 


Leu Asp Ser Asn His Thr Val Gly Val Leu Ala Ser Ala His Arg Pro 
385                 390                 395                 400 


Gln Gly Pro Ala Asp Ala Trp Arg Ala Ala Val Leu Ile Tyr Ala Ser 
                405                 410                 415     


Asp Asp Thr Arg Ala His Pro Asn Arg Ser Val Ala Val Thr Leu Arg 
            420                 425                 430         


Leu Arg Gly Val Pro Pro Gly Pro Gly Leu Val Tyr Val Thr Arg Tyr 
        435                 440                 445             


Leu Asp Asn Gly Leu Cys Ser Pro Asp Gly Glu Trp Arg Arg Leu Gly 
    450                 455                 460                 


Arg Pro Val Phe Pro Thr Ala Glu Gln Phe Arg Arg Met Arg Ala Ala 
465                 470                 475                 480 


Glu Asp Pro Val Ala Ala Ala Pro Arg Pro Leu Pro Ala Gly Gly Arg 
                485                 490                 495     


Leu Thr Leu Arg Pro Ala Leu Arg Leu Pro Ser Leu Leu Leu Val His 
            500                 505                 510         


Val Cys Ala Arg Pro Glu Lys Pro Pro Gly Gln Val Thr Arg Leu Arg 
        515                 520                 525             


Ala Leu Pro Leu Thr Gln Gly Gln Leu Val Leu Val Trp Ser Asp Glu 
    530                 535                 540                 


His Val Gly Ser Lys Cys Leu Trp Thr Tyr Glu Ile Gln Phe Ser Gln 
545                 550                 555                 560 


Asp Gly Lys Ala Tyr Thr Pro Val Ser Arg Lys Pro Ser Thr Phe Asn 
                565                 570                 575     


Leu Phe Val Phe Ser Pro Asp Thr Gly Ala Val Ser Gly Ser Tyr Arg 
            580                 585                 590         


Val Arg Ala Leu Asp Tyr Trp Ala Arg Pro Gly Pro Phe Ser Asp Pro 
        595                 600                 605             


Val Pro Tyr Leu Glu Val Pro Val Pro Arg Gly Pro Pro Ser Pro Gly 
    610                 615                 620                 


Asn Pro 
625     


<210>  411
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Idursulfase

<400>  411

Ser Glu Thr Gln Ala Asn Ser Thr Thr Asp Ala Leu Asn Val Leu Leu 
1               5                   10                  15      


Ile Ile Val Asp Asp Leu Arg Pro Ser Leu Gly Cys Tyr Gly Asp Lys 
            20                  25                  30          


Leu Val Arg Ser Pro Asn Ile Asp Gln Leu Ala Ser His Ser Leu Leu 
        35                  40                  45              


Phe Gln Asn Ala Phe Ala Gln Gln Ala Val Cys Ala Pro Ser Arg Val 
    50                  55                  60                  


Ser Phe Leu Thr Gly Arg Arg Pro Asp Thr Thr Arg Leu Tyr Asp Phe 
65                  70                  75                  80  


Asn Ser Tyr Trp Arg Val His Ala Gly Asn Phe Ser Thr Ile Pro Gln 
                85                  90                  95      


Tyr Phe Lys Glu Asn Gly Tyr Val Thr Met Ser Val Gly Lys Val Phe 
            100                 105                 110         


His Pro Gly Ile Ser Ser Asn His Thr Asp Asp Ser Pro Tyr Ser Trp 
        115                 120                 125             


Ser Phe Pro Pro Tyr His Pro Ser Ser Glu Lys Tyr Glu Asn Thr Lys 
    130                 135                 140                 


Thr Cys Arg Gly Pro Asp Gly Glu Leu His Ala Asn Leu Leu Cys Pro 
145                 150                 155                 160 


Val Asp Val Leu Asp Val Pro Glu Gly Thr Leu Pro Asp Lys Gln Ser 
                165                 170                 175     


Thr Glu Gln Ala Ile Gln Leu Leu Glu Lys Met Lys Thr Ser Ala Ser 
            180                 185                 190         


Pro Phe Phe Leu Ala Val Gly Tyr His Lys Pro His Ile Pro Phe Arg 
        195                 200                 205             


Tyr Pro Lys Glu Phe Gln Lys Leu Tyr Pro Leu Glu Asn Ile Thr Leu 
    210                 215                 220                 


Ala Pro Asp Pro Glu Val Pro Asp Gly Leu Pro Pro Val Ala Tyr Asn 
225                 230                 235                 240 


Pro Trp Met Asp Ile Arg Gln Arg Glu Asp Val Gln Ala Leu Asn Ile 
                245                 250                 255     


Ser Val Pro Tyr Gly Pro Ile Pro Val Asp Phe Gln Arg Lys Ile Arg 
            260                 265                 270         


Gln Ser Tyr Phe Ala Ser Val Ser Tyr Leu Asp Thr Gln Val Gly Arg 
        275                 280                 285             


Leu Leu Ser Ala Leu Asp Asp Leu Gln Leu Ala Asn Ser Thr Ile Ile 
    290                 295                 300                 


Ala Phe Thr Ser Asp His Gly Trp Ala Leu Gly Glu His Gly Glu Trp 
305                 310                 315                 320 


Ala Lys Tyr Ser Asn Phe Asp Val Ala Thr His Val Pro Leu Ile Phe 
                325                 330                 335     


Tyr Val Pro Gly Arg Thr Ala Ser Leu Pro Glu Ala Gly Glu Lys Leu 
            340                 345                 350         


Phe Pro Tyr Leu Asp Pro Phe Asp Ser Ala Ser Gln Leu Met Glu Pro 
        355                 360                 365             


Gly Arg Gln Ser Met Asp Leu Val Glu Leu Val Ser Leu Phe Pro Thr 
    370                 375                 380                 


Leu Ala Gly Leu Ala Gly Leu Gln Val Pro Pro Arg Cys Pro Val Pro 
385                 390                 395                 400 


Ser Phe His Val Glu Leu Cys Arg Glu Gly Lys Asn Leu Leu Lys His 
                405                 410                 415     


Phe Arg Phe Arg Asp Leu Glu Glu Asp Pro Tyr Leu Pro Gly Asn Pro 
            420                 425                 430         


Arg Glu Leu Ile Ala Tyr Ser Gln Tyr Pro Arg Pro Ser Asp Ile Pro 
        435                 440                 445             


Gln Trp Asn Ser Asp Lys Pro Ser Leu Lys Asp Ile Lys Ile Met Gly 
    450                 455                 460                 


Tyr Ser Ile Arg Thr Ile Asp Tyr Arg Tyr Thr Val Trp Val Gly Phe 
465                 470                 475                 480 


Asn Pro Asp Glu Phe Leu Ala Asn Phe Ser Asp Ile His Ala Gly Glu 
                485                 490                 495     


Leu Tyr Phe Val Asp Ser Asp Pro Leu Gln Asp His Asn Met Tyr Asn 
            500                 505                 510         


Asp Ser Gln Gly Gly Asp Leu Phe Gln Leu Leu Met Pro 
        515                 520                 525 


<210>  412
<211>  339
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HLA Class I alpha chain (mouse K2-D1)

<400>  412

Gly Pro His Ser Met Arg Tyr Phe Glu Thr Ala Val Ser Arg Pro Gly 
1               5                   10                  15      


Leu Glu Glu Pro Arg Tyr Ile Ser Val Gly Tyr Val Asp Asn Lys Glu 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Glu Asn Pro Arg Tyr Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Met Glu Gln Glu Gly Pro Glu Tyr Trp Glu Arg Glu Thr 
    50                  55                  60                  


Gln Lys Ala Lys Gly Gln Glu Gln Trp Phe Arg Val Ser Leu Arg Asn 
65                  70                  75                  80  


Leu Leu Gly Tyr Tyr Asn Gln Ser Ala Gly Gly Ser His Thr Leu Gln 
                85                  90                  95      


Gln Met Ser Gly Cys Asp Leu Gly Ser Asp Trp Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr Leu Gln Phe Ala Tyr Glu Gly Arg Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Lys Thr Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Arg 
    130                 135                 140                 


Arg Lys Trp Glu Gln Ser Gly Ala Ala Glu His Tyr Lys Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Glu Cys Val Glu Trp Leu His Arg Tyr Leu Lys Asn Gly Asn 
                165                 170                 175     


Ala Thr Leu Leu Arg Thr Asp Ser Pro Lys Ala His Val Thr His His 
            180                 185                 190         


Pro Arg Ser Lys Gly Glu Val Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Asp Ile Thr Leu Thr Trp Gln Leu Asn Gly Glu Glu Leu 
    210                 215                 220                 


Thr Gln Asp Met Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ser Val Val Val Pro Leu Gly Lys Glu Gln Asn 
                245                 250                 255     


Tyr Thr Cys Arg Val Tyr His Glu Gly Leu Pro Glu Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro Pro Pro Ser Thr Asp Ser Tyr Met Val Ile Val Ala 
        275                 280                 285             


Val Leu Gly Val Leu Gly Ala Met Ala Ile Ile Gly Ala Val Val Ala 
    290                 295                 300                 


Phe Val Met Lys Arg Arg Arg Asn Thr Gly Gly Lys Gly Gly Asp Tyr 
305                 310                 315                 320 


Ala Leu Ala Pro Gly Ser Gln Ser Ser Glu Met Ser Leu Arg Asp Cys 
                325                 330                 335     


Lys Ala Arg 
            


<210>  413
<211>  100
<212>  PRT
<213>  Mus musculus

<400>  413

Ile Gln Lys Thr Pro Gln Ile Gln Val Tyr Ser Arg His Pro Pro Glu 
1               5                   10                  15      


Asn Gly Lys Pro Asn Ile Leu Asn Cys Tyr Val Thr Gln Phe His Pro 
            20                  25                  30          


Pro His Ile Glu Ile Gln Met Leu Lys Asn Gly Lys Lys Ile Pro Lys 
        35                  40                  45              


Val Glu Met Ser Asp Met Ser Phe Ser Lys Asp Trp Ser Phe Tyr Ile 
    50                  55                  60                  


Leu Ala His Thr Glu Phe Thr Pro Thr Glu Thr Asp Thr Tyr Ala Cys 
65                  70                  75                  80  


Arg Val Lys His Ala Ser Met Ala Glu Pro Lys Thr Val Tyr Trp Asp 
                85                  90                  95      


Arg Asp Met Arg 
            100 


<210>  414
<211>  1916
<212>  PRT
<213>  Mus musculus

<400>  414

Met Asp Ala Glu Ser Ile Arg Leu Asn Asn Glu Asn Leu Trp Ala Trp 
1               5                   10                  15      


Leu Val Arg Leu Leu Ser Lys Asn Pro Glu Trp Leu Ser Ala Lys Leu 
            20                  25                  30          


Arg Ser Phe Leu Pro Thr Met Asp Leu Asp Cys Ser Tyr Glu Pro Ser 
        35                  40                  45              


Asn Pro Glu Val Ile His Arg Gln Leu Asn Arg Leu Phe Ala Gln Gly 
    50                  55                  60                  


Met Ala Thr Trp Lys Ser Phe Ile Asn Asp Leu Cys Phe Glu Leu Asp 
65                  70                  75                  80  


Val Pro Leu Asp Met Glu Ile Pro Leu Val Ser Ile Trp Gly Pro Arg 
                85                  90                  95      


Asp Glu Phe Ser Lys Gln Leu Gly Ala Gly Glu Glu Ser Cys Pro Gly 
            100                 105                 110         


Pro Gln Leu Tyr His Gly Ala Lys Arg Pro Phe Gln Ser Tyr Gly Ser 
        115                 120                 125             


Ser Pro Arg Arg Lys Asn Ser Lys Lys Gln Gln Leu Glu Leu Ala Lys 
    130                 135                 140                 


Lys Tyr Leu Lys Leu Leu Lys Thr Ser Ala Gln Gln Trp His Gly Gly 
145                 150                 155                 160 


Val Cys Pro Gly Ala Trp Leu Thr Pro His Ser Pro Gln Thr Tyr Ile 
                165                 170                 175     


Pro Pro Val Leu Gln Trp Ser Arg Ala Thr Ala Pro Leu Asp Ala Gln 
            180                 185                 190         


Glu Gly Ala Thr Leu Gly Asp Pro Glu Ala Ala Asp Asn Ile Asp Val 
        195                 200                 205             


Ser Ile Gln Asp Leu Phe Ser Phe Lys Ala His Lys Gly Pro Arg Val 
    210                 215                 220                 


Thr Val Leu Leu Gly Lys Ala Gly Met Gly Lys Thr Thr Leu Ala Tyr 
225                 230                 235                 240 


Arg Leu Arg Trp Arg Trp Ala Gln Gly Gln Leu Asp Arg Phe Gln Ala 
                245                 250                 255     


Leu Phe Leu Phe Glu Phe Arg Gln Leu Asn Met Ile Thr Gln Leu Pro 
            260                 265                 270         


Thr Leu Pro Gln Leu Leu Phe Asp Leu Tyr Leu Met Pro Glu Ser Glu 
        275                 280                 285             


Pro Asp Ala Val Phe Gln Tyr Leu Lys Glu Asn Ala Gln Glu Val Leu 
    290                 295                 300                 


Leu Ile Phe Asp Gly Leu Asp Glu Ala Leu His Ala Asp Ser Val Gly 
305                 310                 315                 320 


Thr Asp Asn Ala Gly Ser Ala Leu Thr Leu Phe Ser Glu Leu Cys His 
                325                 330                 335     


Gly Asn Leu Leu Pro Gly Cys Trp Val Met Thr Thr Ser Arg Pro Gly 
            340                 345                 350         


Lys Leu Pro Ser Cys Val Pro Thr Glu Ala Ala Thr Val His Met Trp 
        355                 360                 365             


Gly Phe Asp Gly Leu Arg Val Glu Lys Tyr Val Thr Cys Phe Phe Ser 
    370                 375                 380                 


Asp Leu Leu Ser Gln Glu Leu Ala Leu Lys Glu Met Arg Thr Asn Ala 
385                 390                 395                 400 


Arg Leu Arg Gly Met Cys Ala Ile Pro Ala Leu Cys Thr Val Thr Cys 
                405                 410                 415     


Phe Cys Leu Arg Arg Leu Leu Pro Gly Ser Ser Pro Gly Gln Ser Ala 
            420                 425                 430         


Ala Leu Leu Pro Thr Ile Thr Gln Leu Tyr Leu Gln Met Val Glu Thr 
        435                 440                 445             


Phe Ser Pro Ser Glu Thr Leu Leu Asp Thr Ser Ile Leu Gly Phe Gly 
    450                 455                 460                 


Lys Val Ala Leu Arg Gly Leu Asp Thr Gly Lys Val Val Phe Ser Val 
465                 470                 475                 480 


Glu Asp Ile Ser Pro Gln Leu Met Ser Phe Gly Ala Val His Ser Leu 
                485                 490                 495     


Leu Thr Ser Phe Cys Ile His Thr Arg Pro Gly His Glu Glu Ile Gly 
            500                 505                 510         


Tyr Ala Phe Val His Leu Ser Leu Gln Glu Phe Phe Ala Ala Leu Tyr 
        515                 520                 525             


Leu Met Ala Ser His Thr Val Asp Lys Asp Thr Leu Val Glu Tyr Val 
    530                 535                 540                 


Thr Leu Asn Ser His Trp Val Leu Arg Thr Lys Gly Arg Leu Gly Leu 
545                 550                 555                 560 


Ser Asp His Leu Pro Ala Phe Leu Ala Gly Leu Ala Ser His Thr Cys 
                565                 570                 575     


His Met Phe Leu Cys Gln Leu Ala Gln Gln Asp Arg Ala Trp Val Gly 
            580                 585                 590         


Ser Arg Gln Ala Ala Val Ile Gln Val Leu Arg Lys Leu Ala Ser Arg 
        595                 600                 605             


Lys Leu Thr Gly Pro Lys Met Ile Glu Leu Tyr His Cys Val Ala Glu 
    610                 615                 620                 


Thr Gln Asp Leu Glu Leu Ala Arg Phe Thr Ala Gln Ser Leu Pro Ser 
625                 630                 635                 640 


Arg Leu Ser Phe His Asn Phe Pro Leu Thr His Ala Asp Leu Ala Ala 
                645                 650                 655     


Leu Ala Asn Ile Leu Glu His Arg Asp Asp Pro Ile His Leu Asp Phe 
            660                 665                 670         


Asp Gly Cys Pro Leu Glu Pro His Cys Pro Glu Ala Leu Val Gly Cys 
        675                 680                 685             


Gly Gln Val Glu Asn Leu Ser Phe Lys Ser Arg Lys Cys Gly Asp Ala 
    690                 695                 700                 


Phe Ala Glu Ala Leu Cys Arg Ser Leu Pro Thr Met Gly Ser Leu Lys 
705                 710                 715                 720 


Thr Leu Gly Leu Thr Gly Ser Arg Ile Thr Ala Gln Gly Ile Ser His 
                725                 730                 735     


Leu Ile Gln Thr Leu Pro Leu Cys Ser Gln Leu Glu Glu Val Ser Leu 
            740                 745                 750         


His Asp Asn Gln Leu Lys Asp Pro Glu Val Leu Ser Leu Val Glu Leu 
        755                 760                 765             


Leu Pro Ser Leu Pro Lys Leu Gln Lys Leu Asp Leu Ser Arg Asn Ser 
    770                 775                 780                 


Phe Ser Arg Ser Ile Leu Leu Ser Leu Val Lys Val Ala Ile Thr Cys 
785                 790                 795                 800 


Pro Thr Val Arg Lys Leu Gln Val Arg Glu Leu Asp Leu Ile Phe Tyr 
                805                 810                 815     


Leu Ser Pro Val Thr Glu Thr Ala Thr Gln Gln Ser Gly Ala Ser Asp 
            820                 825                 830         


Val Gln Gly Lys Asp Ser Leu Lys Glu Gly Gln Ser Arg Ser Leu Gln 
        835                 840                 845             


Leu Arg Leu Gln Lys Cys Gln Leu Arg Ile Arg Asp Ala Glu Ala Leu 
    850                 855                 860                 


Val Glu Leu Phe Gln Lys Ser Pro Gln Leu Glu Glu Val Asn Leu Ser 
865                 870                 875                 880 


Gly Asn His Leu Glu Asp Asp Gly Cys Arg Leu Val Ala Glu Ala Ala 
                885                 890                 895     


Ser Gln Leu His Ile Ala Gln Lys Leu Asp Leu Ser Asp Asn Gly Leu 
            900                 905                 910         


Ser Gln Thr Gly Val Thr Tyr Val Leu Lys Ala Met Ser Thr Cys Gly 
        915                 920                 925             


Thr Leu Glu Asp Leu His Ile Ser Leu Leu Asn Asn Thr Val Val Leu 
    930                 935                 940                 


Thr Phe Ala Gln Glu Pro Arg Glu Gln Glu Gly Ser Cys Lys Gly Arg 
945                 950                 955                 960 


Ala Pro Leu Ile Ser Phe Val Ser Pro Val Thr Ser Glu Leu Ser Gln 
                965                 970                 975     


Arg Ser Arg Arg Ile Arg Leu Thr His Cys Gly Phe Leu Ala Lys His 
            980                 985                 990         


Thr Glu Thr Leu Cys Glu Ala Leu  Arg Ala Ser Cys Gln  Thr His Asn 
        995                 1000                 1005             


Leu Asp  His Leu Asp Leu Ser  Asp Asn Ser Leu Gly  Gly Lys Gly 
    1010                 1015                 1020             


Val Ile  Leu Leu Thr Glu Leu  Leu Pro Gly Leu Gly  Pro Leu Lys 
    1025                 1030                 1035             


Ser Leu  Asn Leu Ser Arg Asn  Gly Leu Ser Met Asp  Ala Val Phe 
    1040                 1045                 1050             


Ser Leu  Val Gln Cys Leu Ser  Ser Leu Gln Trp Val  Phe His Leu 
    1055                 1060                 1065             


Asp Val  Ser Leu Glu Ser Asp  Cys Ile Phe Leu Arg  Gly Ala Gly 
    1070                 1075                 1080             


Thr Ser  Arg Asp Ala Leu Glu  Pro Lys Phe Gln Thr  Gly Val Gln 
    1085                 1090                 1095             


Val Leu  Glu Leu Ser Gln Arg  Tyr Thr Ser Arg Ser  Phe Cys Leu 
    1100                 1105                 1110             


Gln Glu  Cys Gln Leu Glu Pro  Thr Ser Leu Thr Phe  Leu Cys Ala 
    1115                 1120                 1125             


Thr Leu  Glu Lys Ser Pro Gly  Pro Leu Glu Val Gln  Leu Ser Cys 
    1130                 1135                 1140             


Lys Ser  Leu Ser Asp Asp Ser  Leu Lys Ile Leu Leu  Gln Cys Leu 
    1145                 1150                 1155             


Pro Gln  Leu Pro Gln Leu Ser  Leu Leu Gln Leu Arg  His Thr Val 
    1160                 1165                 1170             


Leu Ser  Ser Arg Ser Pro Phe  Leu Leu Ala Asp Ile  Phe Asn Leu 
    1175                 1180                 1185             


Cys Pro  Arg Val Arg Lys Val  Thr Leu Arg Ser Leu  Cys His Ala 
    1190                 1195                 1200             


Val Leu  His Phe Asp Ser Asn  Glu Glu Gln Glu Gly  Val Cys Cys 
    1205                 1210                 1215             


Gly Phe  Pro Gly Cys Ser Leu  Ser Gln Glu His Met  Glu Thr Leu 
    1220                 1225                 1230             


Cys Cys  Ala Leu Ser Lys Cys  Asn Ala Leu Ser Gln  Leu Asp Leu 
    1235                 1240                 1245             


Thr Asp  Asn Leu Leu Gly Asp  Ile Gly Leu Arg Cys  Leu Leu Glu 
    1250                 1255                 1260             


Cys Leu  Pro Gln Leu Pro Ile  Ser Gly Trp Leu Asp  Leu Ser His 
    1265                 1270                 1275             


Asn Asn  Ile Ser Gln Glu Gly  Ile Leu Tyr Leu Leu  Glu Thr Leu 
    1280                 1285                 1290             


Pro Ser  Tyr Pro Asn Ile Gln  Glu Val Ser Val Ser  Leu Ser Ser 
    1295                 1300                 1305             


Glu Gln  Ile Phe Arg Met Cys  Phe Ser Lys Lys Glu  Gly Ala Gly 
    1310                 1315                 1320             


Thr Ser  Leu Arg Leu Cys Glu  Cys Ser Phe Ser Pro  Glu Gln Val 
    1325                 1330                 1335             


Ser Lys  Leu Ala Ser Ser Leu  Ser Gln Ala Gln Gln  Leu Thr Glu 
    1340                 1345                 1350             


Leu Trp  Leu Thr Lys Cys His  Leu Asp Leu Pro Gln  Leu Thr Met 
    1355                 1360                 1365             


Leu Leu  Asn Leu Val Asn Arg  Pro Thr Gly Leu Leu  Gly Leu Arg 
    1370                 1375                 1380             


Leu Glu  Glu Pro Trp Val Asp  Ser Val Ser Leu Pro  Ala Leu Met 
    1385                 1390                 1395             


Glu Val  Cys Ala Gln Ala Ser  Gly Cys Leu Thr Glu  Leu Ser Ile 
    1400                 1405                 1410             


Ser Glu  Ile Gln Arg Lys Leu  Trp Leu Gln Leu Glu  Phe Pro His 
    1415                 1420                 1425             


Gln Glu  Gly Asn Ser Asp Ser  Met Ala Leu Arg Leu  Ala His Cys 
    1430                 1435                 1440             


Asp Leu  Glu Thr Glu His Ser  His Leu Met Ile Gln  Leu Val Glu 
    1445                 1450                 1455             


Thr Tyr  Ala Arg Leu Gln Gln  Leu Ser Leu Ser Gln  Val Ser Phe 
    1460                 1465                 1470             


Asn Asp  Asn Asp Gly Thr Ser  Ser Lys Leu Leu Gln  Asn Ile Leu 
    1475                 1480                 1485             


Leu Ser  Ser Cys Glu Leu Lys  Ser Phe Arg Leu Thr  Phe Ser Gln 
    1490                 1495                 1500             


Val Ser  Thr Lys Ser Leu Thr  His Leu Ala Phe Gly  Leu Gly His 
    1505                 1510                 1515             


Cys His  His Leu Glu Glu Leu  Asp Phe Ser Asn Asn  Ser Leu Arg 
    1520                 1525                 1530             


Glu Glu  Asp Thr Glu Leu Leu  Met Gly Ala Leu Gln  Gly Thr Cys 
    1535                 1540                 1545             


Arg Leu  Lys Lys Leu His Leu  Ser Phe Leu Pro Leu  Gly Ala Ser 
    1550                 1555                 1560             


Ser Leu  Ala Leu Leu Ile Gln  Gly Leu Ser Arg Met  Thr Leu Leu 
    1565                 1570                 1575             


Gln Asp  Leu Cys Leu Ser His  Asn Gln Ile Gly Asp  Val Gly Thr 
    1580                 1585                 1590             


Gln Cys  Leu Ala Ala Ile Leu  Pro Lys Leu Pro Glu  Leu Arg Lys 
    1595                 1600                 1605             


Phe Asp  Leu Ser His Asn Gln  Ile Gly Asp Val Gly  Thr Gln Cys 
    1610                 1615                 1620             


Leu Ala  Ala Ile Leu Pro Lys  Leu Pro Glu Leu Arg  Lys Phe Asn 
    1625                 1630                 1635             


Leu Ser  His Asn Gln Ile Gly  His Val Gly Thr Gln  Cys Leu Ala 
    1640                 1645                 1650             


Ala Ile  Leu Pro Lys Leu Pro  Glu Leu Arg Lys Phe  Asp Leu Ser 
    1655                 1660                 1665             


Arg Asn  Gln Ile Gly Asp Val  Gly Thr Gln Cys Leu  Ala Ala Ile 
    1670                 1675                 1680             


Leu Pro  Lys Leu Pro Glu Leu  Arg Lys Phe Asp Leu  Ser Gly Asn 
    1685                 1690                 1695             


Arg Ile  Gly Pro Ala Gly Gly  Val Gln Leu Val Lys  Ser Leu Thr 
    1700                 1705                 1710             


His Phe  Glu His Leu Glu Glu  Ile Lys Leu Gly Asn  Asn Ala Leu 
    1715                 1720                 1725             


Gly Glu  Pro Thr Ala Leu Glu  Leu Ala Gln Arg Leu  Pro Pro Gln 
    1730                 1735                 1740             


Leu Arg  Val Leu Cys Leu Pro  Ser Ser His Leu Gly  Pro Glu Gly 
    1745                 1750                 1755             


Ala Leu  Gly Leu Ala Gln Ala  Leu Glu Gln Cys Pro  His Ile Glu 
    1760                 1765                 1770             


Glu Val  Ser Leu Ala Glu Asn  Asn Leu Ala Gly Gly  Val Pro Arg 
    1775                 1780                 1785             


Phe Ser  Lys Arg Leu Pro Leu  Leu Arg Gln Ile Asp  Leu Glu Phe 
    1790                 1795                 1800             


Cys Lys  Ile Glu Asp Gln Ala  Ala Arg His Leu Ala  Ala Asn Leu 
    1805                 1810                 1815             


Thr Leu  Phe Pro Ala Leu Glu  Lys Leu Leu Leu Ser  Gly Asn Leu 
    1820                 1825                 1830             


Leu Gly  Asp Glu Val Ala Ala  Glu Leu Ala Gln Val  Leu Pro Gln 
    1835                 1840                 1845             


Met Gly  Gln Leu Lys Lys Val  Asn Leu Glu Trp Asn  Arg Ile Thr 
    1850                 1855                 1860             


Ala Arg  Gly Ala Gln Leu Leu  Ala Gln Gly Leu Val  Gln Gly Ser 
    1865                 1870                 1875             


Cys Val  Pro Val Ile Arg Leu  Trp Asn Asn Pro Ile  Leu Asn Asp 
    1880                 1885                 1890             


Val Ala  Gln Ser Leu Gln Ser  Gln Glu Pro Arg Leu  Asp Phe Ser 
    1895                 1900                 1905             


Ile Thr  Asp Gln Gln Thr Leu  Arg 
    1910                 1915     


<210>  415
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  415

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Gln Lys Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Gln Glu Thr Arg Asn Met Lys Ala His Ser Gln 
                85                  90                  95      


Thr Asp Arg Ala Asn Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Asp Gly Ser His Thr Ile Gln Ile Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Phe Leu Arg Gly Tyr Arg Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Met Ala Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Val His Ala 
                165                 170                 175     


Ala Glu Gln Arg Arg Val Tyr Leu Glu Gly Arg Cys Val Asp Gly Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro 
        195                 200                 205             


Pro Lys Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Leu Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ala 
305                 310                 315                 320 


Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Lys Ser 
                325                 330                 335     


Ser Asp Arg Lys Gly Gly Ser Tyr Thr Gln Ala Ala Ser Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val 
        355                 360                 365 


<210>  416
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  416

Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu 
1               5                   10                  15      


Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro 
            20                  25                  30          


Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys 
        35                  40                  45              


Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu 
    50                  55                  60                  


Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys 
65                  70                  75                  80  


Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp 
                85                  90                  95      


Arg Asp Met 
            


<210>  417
<211>  1866
<212>  PRT
<213>  Homo sapiens

<400>  417

Met Asp Pro Val Gly Leu Gln Leu Gly Asn Lys Asn Leu Trp Ser Cys 
1               5                   10                  15      


Leu Val Arg Leu Leu Thr Lys Asp Pro Glu Trp Leu Asn Ala Lys Met 
            20                  25                  30          


Lys Phe Phe Leu Pro Asn Thr Asp Leu Asp Ser Arg Asn Glu Thr Leu 
        35                  40                  45              


Asp Pro Glu Gln Arg Val Ile Leu Gln Leu Asn Lys Leu His Val Gln 
    50                  55                  60                  


Gly Ser Asp Thr Trp Gln Ser Phe Ile His Cys Val Cys Met Gln Leu 
65                  70                  75                  80  


Glu Val Pro Leu Asp Leu Glu Val Leu Leu Leu Ser Thr Phe Gly Tyr 
                85                  90                  95      


Asp Asp Gly Phe Thr Ser Gln Leu Gly Ala Glu Gly Lys Ser Gln Pro 
            100                 105                 110         


Glu Ser Gln Leu His His Gly Leu Lys Arg Pro His Gln Ser Cys Gly 
        115                 120                 125             


Ser Ser Pro Arg Arg Lys Gln Cys Lys Lys Gln Gln Leu Glu Leu Ala 
    130                 135                 140                 


Lys Lys Tyr Leu Gln Leu Leu Arg Thr Ser Ala Gln Gln Arg Tyr Arg 
145                 150                 155                 160 


Ser Gln Ile Pro Gly Ser Gly Gln Pro His Ala Phe His Gln Val Tyr 
                165                 170                 175     


Val Pro Pro Ile Leu Arg Arg Ala Thr Ala Ser Leu Asp Thr Pro Glu 
            180                 185                 190         


Gly Ala Ile Met Gly Asp Val Lys Val Glu Asp Gly Ala Asp Val Ser 
        195                 200                 205             


Ile Ser Asp Leu Phe Asn Thr Arg Val Asn Lys Gly Pro Arg Val Thr 
    210                 215                 220                 


Val Leu Leu Gly Lys Ala Gly Met Gly Lys Thr Thr Leu Ala His Arg 
225                 230                 235                 240 


Leu Cys Gln Lys Trp Ala Glu Gly His Leu Asn Cys Phe Gln Ala Leu 
                245                 250                 255     


Phe Leu Phe Glu Phe Arg Gln Leu Asn Leu Ile Thr Arg Phe Leu Thr 
            260                 265                 270         


Pro Ser Glu Leu Leu Phe Asp Leu Tyr Leu Ser Pro Glu Ser Asp His 
        275                 280                 285             


Asp Thr Val Phe Gln Tyr Leu Glu Lys Asn Ala Asp Gln Val Leu Leu 
    290                 295                 300                 


Ile Phe Asp Gly Leu Asp Glu Ala Leu Gln Pro Met Gly Pro Asp Gly 
305                 310                 315                 320 


Pro Gly Pro Val Leu Thr Leu Phe Ser His Leu Cys Asn Gly Thr Leu 
                325                 330                 335     


Leu Pro Gly Cys Arg Val Met Ala Thr Ser Arg Pro Gly Lys Leu Pro 
            340                 345                 350         


Ala Cys Leu Pro Ala Glu Ala Ala Met Val His Met Leu Gly Phe Asp 
        355                 360                 365             


Gly Pro Arg Val Glu Glu Tyr Val Asn His Phe Phe Ser Ala Gln Pro 
    370                 375                 380                 


Ser Arg Glu Gly Ala Leu Val Glu Leu Gln Thr Asn Gly Arg Leu Arg 
385                 390                 395                 400 


Ser Leu Cys Ala Val Pro Ala Leu Cys Gln Val Ala Cys Leu Cys Leu 
                405                 410                 415     


His His Leu Leu Pro Asp His Ala Pro Gly Gln Ser Val Ala Leu Leu 
            420                 425                 430         


Pro Asn Met Thr Gln Leu Tyr Met Gln Met Val Leu Ala Leu Ser Pro 
        435                 440                 445             


Pro Gly His Leu Pro Thr Ser Ser Leu Leu Asp Leu Gly Glu Val Ala 
    450                 455                 460                 


Leu Arg Gly Leu Glu Thr Gly Lys Val Ile Phe Tyr Ala Lys Asp Ile 
465                 470                 475                 480 


Ala Pro Pro Leu Ile Ala Phe Gly Ala Thr His Ser Leu Leu Thr Ser 
                485                 490                 495     


Phe Cys Val Cys Thr Gly Pro Gly His Gln Gln Thr Gly Tyr Ala Phe 
            500                 505                 510         


Thr His Leu Ser Leu Gln Glu Phe Leu Ala Ala Leu His Leu Met Ala 
        515                 520                 525             


Ser Pro Lys Val Asn Lys Asp Thr Leu Thr Gln Tyr Val Thr Leu His 
    530                 535                 540                 


Ser Arg Trp Val Gln Arg Thr Lys Ala Arg Leu Gly Leu Ser Asp His 
545                 550                 555                 560 


Leu Pro Thr Phe Leu Ala Gly Leu Ala Ser Cys Thr Cys Arg Pro Phe 
                565                 570                 575     


Leu Ser His Leu Ala Gln Gly Asn Glu Asp Cys Val Gly Ala Lys Gln 
            580                 585                 590         


Ala Ala Val Val Gln Val Leu Lys Lys Leu Ala Thr Arg Lys Leu Thr 
        595                 600                 605             


Gly Pro Lys Val Val Glu Leu Cys His Cys Val Asp Glu Thr Gln Glu 
    610                 615                 620                 


Pro Glu Leu Ala Ser Leu Thr Ala Gln Ser Leu Pro Tyr Gln Leu Pro 
625                 630                 635                 640 


Phe His Asn Phe Pro Leu Thr Cys Thr Asp Leu Ala Thr Leu Thr Asn 
                645                 650                 655     


Ile Leu Glu His Arg Glu Ala Pro Ile His Leu Asp Phe Asp Gly Cys 
            660                 665                 670         


Pro Leu Glu Pro His Cys Pro Glu Ala Leu Val Gly Cys Gly Gln Ile 
        675                 680                 685             


Glu Asn Leu Ser Phe Lys Ser Arg Lys Cys Gly Asp Ala Phe Ala Glu 
    690                 695                 700                 


Ala Leu Ser Arg Ser Leu Pro Thr Met Gly Arg Leu Gln Met Leu Gly 
705                 710                 715                 720 


Leu Ala Gly Ser Lys Ile Thr Ala Arg Gly Ile Ser His Leu Val Lys 
                725                 730                 735     


Ala Leu Pro Leu Cys Pro Gln Leu Lys Glu Val Ser Phe Arg Asp Asn 
            740                 745                 750         


Gln Leu Ser Asp Gln Val Val Leu Asn Ile Val Glu Val Leu Pro His 
        755                 760                 765             


Leu Pro Arg Leu Arg Lys Leu Asp Leu Ser Ser Asn Ser Ile Cys Val 
    770                 775                 780                 


Ser Thr Leu Leu Cys Leu Ala Arg Val Ala Val Thr Cys Pro Thr Val 
785                 790                 795                 800 


Arg Met Leu Gln Ala Arg Glu Ala Asp Leu Ile Phe Leu Leu Ser Pro 
                805                 810                 815     


Pro Thr Glu Thr Thr Ala Glu Leu Gln Arg Ala Pro Asp Leu Gln Glu 
            820                 825                 830         


Ser Asp Gly Gln Arg Lys Gly Ala Gln Ser Arg Ser Leu Thr Leu Arg 
        835                 840                 845             


Leu Gln Lys Cys Gln Leu Gln Val His Asp Ala Glu Ala Leu Ile Ala 
    850                 855                 860                 


Leu Leu Gln Glu Gly Pro His Leu Glu Glu Val Asp Leu Ser Gly Asn 
865                 870                 875                 880 


Gln Leu Glu Asp Glu Gly Cys Arg Leu Met Ala Glu Ala Ala Ser Gln 
                885                 890                 895     


Leu His Ile Ala Arg Lys Leu Asp Leu Ser Asn Asn Gly Leu Ser Val 
            900                 905                 910         


Ala Gly Val His Cys Val Leu Arg Ala Val Ser Ala Cys Trp Thr Leu 
        915                 920                 925             


Ala Glu Leu His Ile Ser Leu Gln His Lys Thr Val Ile Phe Met Phe 
    930                 935                 940                 


Ala Gln Glu Pro Glu Glu Gln Lys Gly Pro Gln Glu Arg Ala Ala Phe 
945                 950                 955                 960 


Leu Asp Ser Leu Met Leu Gln Met Pro Ser Glu Leu Pro Leu Ser Ser 
                965                 970                 975     


Arg Arg Met Arg Leu Thr His Cys Gly Leu Gln Glu Lys His Leu Glu 
            980                 985                 990         


Gln Leu Cys Lys Ala Leu Gly Gly  Ser Cys His Leu Gly  His Leu His 
        995                 1000                 1005             


Leu Asp  Phe Ser Gly Asn Ala  Leu Gly Asp Glu Gly  Ala Ala Arg 
    1010                 1015                 1020             


Leu Ala  Gln Leu Leu Pro Gly  Leu Gly Ala Leu Gln  Ser Leu Asn 
    1025                 1030                 1035             


Leu Ser  Glu Asn Gly Leu Ser  Leu Asp Ala Val Leu  Gly Leu Val 
    1040                 1045                 1050             


Arg Cys  Phe Ser Thr Leu Gln  Trp Leu Phe Arg Leu  Asp Ile Ser 
    1055                 1060                 1065             


Phe Glu  Ser Gln His Ile Leu  Leu Arg Gly Asp Lys  Thr Ser Arg 
    1070                 1075                 1080             


Asp Met  Trp Ala Thr Gly Ser  Leu Pro Asp Phe Pro  Ala Ala Ala 
    1085                 1090                 1095             


Lys Phe  Leu Gly Phe Arg Gln  Arg Cys Ile Pro Arg  Ser Leu Cys 
    1100                 1105                 1110             


Leu Ser  Glu Cys Pro Leu Glu  Pro Pro Ser Leu Thr  Arg Leu Cys 
    1115                 1120                 1125             


Ala Thr  Leu Lys Asp Cys Pro  Gly Pro Leu Glu Leu  Gln Leu Ser 
    1130                 1135                 1140             


Cys Glu  Phe Leu Ser Asp Gln  Ser Leu Glu Thr Leu  Leu Asp Cys 
    1145                 1150                 1155             


Leu Pro  Gln Leu Pro Gln Leu  Ser Leu Leu Gln Leu  Ser Gln Thr 
    1160                 1165                 1170             


Gly Leu  Ser Pro Lys Ser Pro  Phe Leu Leu Ala Asn  Thr Leu Ser 
    1175                 1180                 1185             


Leu Cys  Pro Arg Val Lys Lys  Val Asp Leu Arg Ser  Leu His His 
    1190                 1195                 1200             


Ala Thr  Leu His Phe Arg Ser  Asn Glu Glu Glu Glu  Gly Val Cys 
    1205                 1210                 1215             


Cys Gly  Arg Phe Thr Gly Cys  Ser Leu Ser Gln Glu  His Val Glu 
    1220                 1225                 1230             


Ser Leu  Cys Trp Leu Leu Ser  Lys Cys Lys Asp Leu  Ser Gln Val 
    1235                 1240                 1245             


Asp Leu  Ser Ala Asn Leu Leu  Gly Asp Ser Gly Leu  Arg Cys Leu 
    1250                 1255                 1260             


Leu Glu  Cys Leu Pro Gln Val  Pro Ile Ser Gly Leu  Leu Asp Leu 
    1265                 1270                 1275             


Ser His  Asn Ser Ile Ser Gln  Glu Ser Ala Leu Tyr  Leu Leu Glu 
    1280                 1285                 1290             


Thr Leu  Pro Ser Cys Pro Arg  Val Arg Glu Ala Ser  Val Asn Leu 
    1295                 1300                 1305             


Gly Ser  Glu Gln Ser Phe Arg  Ile His Phe Ser Arg  Glu Asp Gln 
    1310                 1315                 1320             


Ala Gly  Lys Thr Leu Arg Leu  Ser Glu Cys Ser Phe  Arg Pro Glu 
    1325                 1330                 1335             


His Val  Ser Arg Leu Ala Thr  Gly Leu Ser Lys Ser  Leu Gln Leu 
    1340                 1345                 1350             


Thr Glu  Leu Thr Leu Thr Gln  Cys Cys Leu Gly Gln  Lys Gln Leu 
    1355                 1360                 1365             


Ala Ile  Leu Leu Ser Leu Val  Gly Arg Pro Ala Gly  Leu Phe Ser 
    1370                 1375                 1380             


Leu Arg  Val Gln Glu Pro Trp  Ala Asp Arg Ala Arg  Val Leu Ser 
    1385                 1390                 1395             


Leu Leu  Glu Val Cys Ala Gln  Ala Ser Gly Ser Val  Thr Glu Ile 
    1400                 1405                 1410             


Ser Ile  Ser Glu Thr Gln Gln  Gln Leu Cys Val Gln  Leu Glu Phe 
    1415                 1420                 1425             


Pro Arg  Gln Glu Glu Asn Pro  Glu Ala Val Ala Leu  Arg Leu Ala 
    1430                 1435                 1440             


His Cys  Asp Leu Gly Ala His  His Ser Leu Leu Val  Gly Gln Leu 
    1445                 1450                 1455             


Met Glu  Thr Cys Ala Arg Leu  Gln Gln Leu Ser Leu  Ser Gln Val 
    1460                 1465                 1470             


Asn Leu  Cys Glu Asp Asp Asp  Ala Ser Ser Leu Leu  Leu Gln Ser 
    1475                 1480                 1485             


Leu Leu  Leu Ser Leu Ser Glu  Leu Lys Thr Phe Arg  Leu Thr Ser 
    1490                 1495                 1500             


Ser Cys  Val Ser Thr Glu Gly  Leu Ala His Leu Ala  Ser Gly Leu 
    1505                 1510                 1515             


Gly His  Cys His His Leu Glu  Glu Leu Asp Leu Ser  Asn Asn Gln 
    1520                 1525                 1530             


Phe Asp  Glu Glu Gly Thr Lys  Ala Leu Met Arg Ala  Leu Glu Gly 
    1535                 1540                 1545             


Lys Trp  Met Leu Lys Arg Leu  Asp Leu Ser His Leu  Leu Leu Asn 
    1550                 1555                 1560             


Ser Ser  Thr Leu Ala Leu Leu  Thr His Arg Leu Ser  Gln Met Thr 
    1565                 1570                 1575             


Cys Leu  Gln Ser Leu Arg Leu  Asn Arg Asn Ser Ile  Gly Asp Val 
    1580                 1585                 1590             


Gly Cys  Cys His Leu Ser Glu  Ala Leu Arg Ala Ala  Thr Ser Leu 
    1595                 1600                 1605             


Glu Glu  Leu Asp Leu Ser His  Asn Gln Ile Gly Asp  Ala Gly Val 
    1610                 1615                 1620             


Gln His  Leu Ala Thr Ile Leu  Pro Gly Leu Pro Glu  Leu Arg Lys 
    1625                 1630                 1635             


Ile Asp  Leu Ser Gly Asn Ser  Ile Ser Ser Ala Gly  Gly Val Gln 
    1640                 1645                 1650             


Leu Ala  Glu Ser Leu Val Leu  Cys Arg Arg Leu Glu  Glu Leu Met 
    1655                 1660                 1665             


Leu Gly  Cys Asn Ala Leu Gly  Asp Pro Thr Ala Leu  Gly Leu Ala 
    1670                 1675                 1680             


Gln Glu  Leu Pro Gln His Leu  Arg Val Leu His Leu  Pro Phe Ser 
    1685                 1690                 1695             


His Leu  Gly Pro Gly Gly Ala  Leu Ser Leu Ala Gln  Ala Leu Asp 
    1700                 1705                 1710             


Gly Ser  Pro His Leu Glu Glu  Ile Ser Leu Ala Glu  Asn Asn Leu 
    1715                 1720                 1725             


Ala Gly  Gly Val Leu Arg Phe  Cys Met Glu Leu Pro  Leu Leu Arg 
    1730                 1735                 1740             


Gln Ile  Asp Leu Val Ser Cys  Lys Ile Asp Asn Gln  Thr Ala Lys 
    1745                 1750                 1755             


Leu Leu  Thr Ser Ser Phe Thr  Ser Cys Pro Ala Leu  Glu Val Ile 
    1760                 1765                 1770             


Leu Leu  Ser Trp Asn Leu Leu  Gly Asp Glu Ala Ala  Ala Glu Leu 
    1775                 1780                 1785             


Ala Gln  Val Leu Pro Gln Met  Gly Arg Leu Lys Arg  Val Asp Leu 
    1790                 1795                 1800             


Glu Lys  Asn Gln Ile Thr Ala  Leu Gly Ala Trp Leu  Leu Ala Glu 
    1805                 1810                 1815             


Gly Leu  Ala Gln Gly Ser Ser  Ile Gln Val Ile Arg  Leu Trp Asn 
    1820                 1825                 1830             


Asn Pro  Ile Pro Cys Asp Met  Ala Gln His Leu Lys  Ser Gln Glu 
    1835                 1840                 1845             


Pro Arg  Leu Asp Phe Ala Phe  Phe Asp Asn Gln Pro  Gln Ala Pro 
    1850                 1855                 1860             


Trp Gly  Thr 
    1865     


<210>  418
<211>  313
<212>  PRT
<213>  Mus musculus

<400>  418

Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser 
305                 310             


<210>  419
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  419

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser 
305     


<210>  420
<211>  883
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Alglucosidase alfa

<400>  420

Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr Gln Cys Asp Val Pro 
1               5                   10                  15      


Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys Ala Ile Thr Gln Glu 
            20                  25                  30          


Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro Ala Lys Gln Gly Leu 
        35                  40                  45              


Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe Phe Pro Pro Ser Tyr 
    50                  55                  60                  


Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser Glu Met Gly Tyr Thr 
65                  70                  75                  80  


Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe Pro Lys Asp Ile Leu 
                85                  90                  95      


Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu Asn Arg Leu His Phe 
            100                 105                 110         


Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu Val Pro Leu Glu Thr 
        115                 120                 125             


Pro His Val His Ser Arg Ala Pro Ser Pro Leu Tyr Ser Val Glu Phe 
    130                 135                 140                 


Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg Gln Leu Asp Gly Arg 
145                 150                 155                 160 


Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe Phe Ala Asp Gln Phe 
                165                 170                 175     


Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr Ile Thr Gly Leu Ala 
            180                 185                 190         


Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser Trp Thr Arg Ile Thr 
        195                 200                 205             


Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly Ala Asn Leu Tyr Gly 
    210                 215                 220                 


Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly Gly Ser Ala His Gly 
225                 230                 235                 240 


Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val Val Leu Gln Pro Ser 
                245                 250                 255     


Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile Leu Asp Val Tyr Ile 
            260                 265                 270         


Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln Gln Tyr Leu Asp Val 
        275                 280                 285             


Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly Leu Gly Phe His Leu 
    290                 295                 300                 


Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr Arg Gln Val Val Glu 
305                 310                 315                 320 


Asn Met Thr Arg Ala His Phe Pro Leu Asp Val Gln Trp Asn Asp Leu 
                325                 330                 335     


Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe Asn Lys Asp Gly Phe 
            340                 345                 350         


Arg Asp Phe Pro Ala Met Val Gln Glu Leu His Gln Gly Gly Arg Arg 
        355                 360                 365             


Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser Ser Gly Pro Ala Gly 
    370                 375                 380                 


Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg Gly Val Phe Ile Thr 
385                 390                 395                 400 


Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val Trp Pro Gly Ser Thr 
                405                 410                 415     


Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu Ala Trp Trp Glu Asp 
            420                 425                 430         


Met Val Ala Glu Phe His Asp Gln Val Pro Phe Asp Gly Met Trp Ile 
        435                 440                 445             


Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly Ser Glu Asp Gly Cys 
    450                 455                 460                 


Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val Pro Gly Val Val Gly 
465                 470                 475                 480 


Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser Ser His Gln Phe Leu 
                485                 490                 495     


Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly Leu Thr Glu Ala Ile 
            500                 505                 510         


Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly Thr Arg Pro Phe Val 
        515                 520                 525             


Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg Tyr Ala Gly His Trp 
    530                 535                 540                 


Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu Ala Ser Ser Val Pro 
545                 550                 555                 560 


Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro Leu Val Gly Ala Asp 
                565                 570                 575     


Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu Leu Cys Val Arg Trp 
            580                 585                 590         


Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg Asn His Asn Ser Leu 
        595                 600                 605             


Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser Glu Pro Ala Gln Gln 
    610                 615                 620                 


Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala Leu Leu Pro His Leu 
625                 630                 635                 640 


Tyr Thr Leu Phe His Gln Ala His Val Ala Gly Glu Thr Val Ala Arg 
                645                 650                 655     


Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser Thr Trp Thr Val Asp 
            660                 665                 670         


His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile Thr Pro Val Leu Gln 
        675                 680                 685             


Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro Leu Gly Thr Trp Tyr 
    690                 695                 700                 


Asp Leu Gln Thr Val Pro Val Glu Ala Leu Gly Ser Leu Pro Pro Pro 
705                 710                 715                 720 


Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser Glu Gly Gln Trp Val 
                725                 730                 735     


Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val His Leu Arg Ala Gly 
            740                 745                 750         


Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr Thr Thr Glu Ser Arg 
        755                 760                 765             


Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr Lys Gly Gly Glu Ala 
    770                 775                 780                 


Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser Leu Glu Val Leu Glu 
785                 790                 795                 800 


Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala Arg Asn Asn Thr Ile 
                805                 810                 815     


Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly Ala Gly Leu Gln Leu 
            820                 825                 830         


Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala Pro Gln Gln Val Leu 
        835                 840                 845             


Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr Ser Pro Asp Thr Lys 
    850                 855                 860                 


Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly Glu Gln Phe Leu Val 
865                 870                 875                 880 


Ser Trp Cys 
            


<210>  421
<211>  1438
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  B-domain deleted human Factor VIII (BDD FVIII)

<400>  421

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His 
            740                 745                 750         


Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile 
        755                 760                 765             


Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp 
    770                 775                 780                 


Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys 
785                 790                 795                 800 


Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly 
                805                 810                 815     


Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser 
            820                 825                 830         


Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser 
        835                 840                 845             


Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu 
    850                 855                 860                 


Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr 
865                 870                 875                 880 


Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile 
                885                 890                 895     


Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe 
            900                 905                 910         


Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His 
        915                 920                 925             


Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe 
    930                 935                 940                 


Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro 
945                 950                 955                 960 


Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln 
                965                 970                 975     


Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr 
            980                 985                 990         


Lys Ser Trp Tyr Phe Thr Glu Asn  Met Glu Arg Asn Cys  Arg Ala Pro 
        995                 1000                 1005             


Cys Asn  Ile Gln Met Glu Asp  Pro Thr Phe Lys Glu  Asn Tyr Arg 
    1010                 1015                 1020             


Phe His  Ala Ile Asn Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu 
    1025                 1030                 1035             


Val Met  Ala Gln Asp Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met 
    1040                 1045                 1050             


Gly Ser  Asn Glu Asn Ile His  Ser Ile His Phe Ser  Gly His Val 
    1055                 1060                 1065             


Phe Thr  Val Arg Lys Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn 
    1070                 1075                 1080             


Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys 
    1085                 1090                 1095             


Ala Gly  Ile Trp Arg Val Glu  Cys Leu Ile Gly Glu  His Leu His 
    1100                 1105                 1110             


Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln 
    1115                 1120                 1125             


Thr Pro  Leu Gly Met Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile 
    1130                 1135                 1140             


Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg 
    1145                 1150                 1155             


Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro 
    1160                 1165                 1170             


Phe Ser  Trp Ile Lys Val Asp  Leu Leu Ala Pro Met  Ile Ile His 
    1175                 1180                 1185             


Gly Ile  Lys Thr Gln Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr 
    1190                 1195                 1200             


Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Trp 
    1205                 1210                 1215             


Gln Thr  Tyr Arg Gly Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe 
    1220                 1225                 1230             


Gly Asn  Val Asp Ser Ser Gly  Ile Lys His Asn Ile  Phe Asn Pro 
    1235                 1240                 1245             


Pro Ile  Ile Ala Arg Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser 
    1250                 1255                 1260             


Ile Arg  Ser Thr Leu Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn 
    1265                 1270                 1275             


Ser Cys  Ser Met Pro Leu Gly  Met Glu Ser Lys Ala  Ile Ser Asp 
    1280                 1285                 1290             


Ala Gln  Ile Thr Ala Ser Ser  Tyr Phe Thr Asn Met  Phe Ala Thr 
    1295                 1300                 1305             


Trp Ser  Pro Ser Lys Ala Arg  Leu His Leu Gln Gly  Arg Ser Asn 
    1310                 1315                 1320             


Ala Trp  Arg Pro Gln Val Asn  Asn Pro Lys Glu Trp  Leu Gln Val 
    1325                 1330                 1335             


Asp Phe  Gln Lys Thr Met Lys  Val Thr Gly Val Thr  Thr Gln Gly 
    1340                 1345                 1350             


Val Lys  Ser Leu Leu Thr Ser  Met Tyr Val Lys Glu  Phe Leu Ile 
    1355                 1360                 1365             


Ser Ser  Ser Gln Asp Gly His  Gln Trp Thr Leu Phe  Phe Gln Asn 
    1370                 1375                 1380             


Gly Lys  Val Lys Val Phe Gln  Gly Asn Gln Asp Ser  Phe Thr Pro 
    1385                 1390                 1395             


Val Val  Asn Ser Leu Asp Pro  Pro Leu Leu Thr Arg  Tyr Leu Arg 
    1400                 1405                 1410             


Ile His  Pro Gln Ser Trp Val  His Gln Ile Ala Leu  Arg Met Glu 
    1415                 1420                 1425             


Val Leu  Gly Cys Glu Ala Gln  Asp Leu Tyr 
    1430                 1435             


<210>  422
<211>  2791
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Von Willebrand Factor, recombinant

<400>  422

Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr Ala Arg Cys Ser Leu Phe 
1               5                   10                  15      


Gly Ser Asp Phe Val Asn Thr Phe Asp Gly Ser Met Tyr Ser Phe Ala 
            20                  25                  30          


Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly Cys Gln Lys Arg Ser Phe 
        35                  40                  45              


Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys Arg Val Ser Leu Ser Val 
    50                  55                  60                  


Tyr Leu Gly Glu Phe Phe Asp Ile His Leu Phe Val Asn Gly Thr Val 
65                  70                  75                  80  


Thr Gln Gly Asp Gln Arg Val Ser Met Pro Tyr Ala Ser Lys Gly Leu 
                85                  90                  95      


Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys Leu Ser Gly Glu Ala Tyr 
            100                 105                 110         


Gly Phe Val Ala Arg Ile Asp Gly Ser Gly Asn Phe Gln Val Leu Leu 
        115                 120                 125             


Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly Leu Cys Gly Asn Phe Asn 
    130                 135                 140                 


Ile Phe Ala Glu Asp Asp Phe Met Thr Gln Glu Gly Thr Leu Thr Ser 
145                 150                 155                 160 


Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala Leu Ser Ser Gly Glu Gln 
                165                 170                 175     


Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser Ser Cys Asn Ile Ser Ser 
            180                 185                 190         


Gly Glu Met Gln Lys Gly Leu Trp Glu Gln Cys Gln Leu Leu Lys Ser 
        195                 200                 205             


Thr Ser Val Phe Ala Arg Cys His Pro Leu Val Asp Pro Glu Pro Phe 
    210                 215                 220                 


Val Ala Leu Cys Glu Lys Thr Leu Cys Glu Cys Ala Gly Gly Leu Glu 
225                 230                 235                 240 


Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala Arg Thr Cys Ala Gln Glu 
                245                 250                 255     


Gly Met Val Leu Tyr Gly Trp Thr Asp His Ser Ala Cys Ser Pro Val 
            260                 265                 270         


Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys Val Ser Pro Cys Ala Arg 
        275                 280                 285             


Thr Cys Gln Ser Leu His Ile Asn Glu Met Cys Gln Glu Arg Cys Val 
    290                 295                 300                 


Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu Leu Asp Glu Gly Leu Cys 
305                 310                 315                 320 


Val Glu Ser Thr Glu Cys Pro Cys Val His Ser Gly Lys Arg Tyr Pro 
                325                 330                 335     


Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn Thr Cys Ile Cys Arg Asn 
            340                 345                 350         


Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys Pro Gly Glu Cys Leu Val 
        355                 360                 365             


Thr Gly Gln Ser His Phe Lys Ser Phe Asp Asn Arg Tyr Phe Thr Phe 
    370                 375                 380                 


Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg Asp Cys Gln Asp His Ser 
385                 390                 395                 400 


Phe Ser Ile Val Ile Glu Thr Val Gln Cys Ala Asp Asp Arg Asp Ala 
                405                 410                 415     


Val Cys Thr Arg Ser Val Thr Val Arg Leu Pro Gly Leu His Asn Ser 
            420                 425                 430         


Leu Val Lys Leu Lys His Gly Ala Gly Val Ala Met Asp Gly Gln Asp 
        435                 440                 445             


Val Gln Leu Pro Leu Leu Lys Gly Asp Leu Arg Ile Gln His Thr Val 
    450                 455                 460                 


Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu Asp Leu Gln Met Asp Trp 
465                 470                 475                 480 


Asp Gly Arg Gly Arg Leu Leu Val Lys Leu Ser Pro Val Tyr Ala Gly 
                485                 490                 495     


Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn Gly Asn Gln Gly Asp Asp 
            500                 505                 510         


Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro Arg Val Glu Asp Phe Gly 
        515                 520                 525             


Asn Ala Trp Lys Leu His Gly Asp Cys Gln Asp Leu Gln Lys Gln His 
    530                 535                 540                 


Ser Asp Pro Cys Ala Leu Asn Pro Arg Met Thr Arg Phe Ser Glu Glu 
545                 550                 555                 560 


Ala Cys Ala Val Leu Thr Ser Pro Thr Phe Glu Ala Cys His Arg Ala 
                565                 570                 575     


Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys Arg Tyr Asp Val Cys Ser 
            580                 585                 590         


Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly Ala Leu Ala Ser Tyr Ala 
        595                 600                 605             


Ala Ala Cys Ala Gly Arg Gly Val Arg Val Ala Trp Arg Glu Pro Gly 
    610                 615                 620                 


Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln Val Tyr Leu Gln Cys Gly 
625                 630                 635                 640 


Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu Ser Tyr Pro Asp Glu Glu 
                645                 650                 655     


Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe Cys Pro Pro Gly Leu Tyr 
            660                 665                 670         


Met Asp Glu Arg Gly Asp Cys Val Pro Lys Ala Gln Cys Pro Cys Tyr 
        675                 680                 685             


Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp Ile Phe Ser Asp His His 
    690                 695                 700                 


Thr Met Cys Tyr Cys Glu Asp Gly Phe Met His Cys Thr Met Ser Gly 
705                 710                 715                 720 


Val Pro Gly Ser Leu Leu Pro Asp Ala Val Leu Ser Ser Pro Leu Ser 
                725                 730                 735     


His Arg Ser Lys Arg Ser Leu Ser Cys Arg Pro Pro Met Val Lys Leu 
            740                 745                 750         


Val Cys Pro Ala Asp Asn Leu Arg Ala Glu Gly Leu Glu Cys Thr Lys 
        755                 760                 765             


Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met Ser Met Gly Cys Val Ser 
    770                 775                 780                 


Gly Cys Leu Cys Pro Pro Gly Met Val Arg His Glu Asn Arg Cys Val 
785                 790                 795                 800 


Ala Leu Glu Arg Cys Pro Cys Phe His Gln Gly Lys Glu Tyr Ala Pro 
                805                 810                 815     


Gly Glu Thr Val Lys Ile Gly Cys Asn Thr Cys Val Cys Gln Asp Arg 
            820                 825                 830         


Lys Trp Asn Cys Thr Asp His Val Cys Asp Ala Thr Cys Ser Thr Ile 
        835                 840                 845             


Gly Met Ala His Tyr Leu Thr Phe Asp Gly Leu Lys Tyr Leu Phe Pro 
    850                 855                 860                 


Gly Glu Cys Gln Tyr Val Leu Val Gln Asp Tyr Cys Gly Ser Asn Pro 
865                 870                 875                 880 


Gly Thr Phe Arg Ile Leu Val Gly Asn Lys Gly Cys Ser His Pro Ser 
                885                 890                 895     


Val Lys Cys Lys Lys Arg Val Thr Ile Leu Val Glu Gly Gly Glu Ile 
            900                 905                 910         


Glu Leu Phe Asp Gly Glu Val Asn Val Lys Arg Pro Met Lys Asp Glu 
        915                 920                 925             


Thr His Phe Glu Val Val Glu Ser Gly Arg Tyr Ile Ile Leu Leu Leu 
    930                 935                 940                 


Gly Lys Ala Leu Ser Val Val Trp Asp Arg His Leu Ser Ile Ser Val 
945                 950                 955                 960 


Val Leu Lys Gln Thr Tyr Gln Glu Lys Val Cys Gly Leu Cys Gly Asn 
                965                 970                 975     


Phe Asp Gly Ile Gln Asn Asn Asp Leu Thr Ser Ser Asn Leu Gln Val 
            980                 985                 990         


Glu Glu Asp Pro Val Asp Phe Gly  Asn Ser Trp Lys Val  Ser Ser Gln 
        995                 1000                 1005             


Cys Ala  Asp Thr Arg Lys Val  Pro Leu Asp Ser Ser  Pro Ala Thr 
    1010                 1015                 1020             


Cys His  Asn Asn Ile Met Lys  Gln Thr Met Val Asp  Ser Ser Cys 
    1025                 1030                 1035             


Arg Ile  Leu Thr Ser Asp Val  Phe Gln Asp Cys Asn  Lys Leu Val 
    1040                 1045                 1050             


Asp Pro  Glu Pro Tyr Leu Asp  Val Cys Ile Tyr Asp  Thr Cys Ser 
    1055                 1060                 1065             


Cys Glu  Ser Ile Gly Asp Cys  Ala Cys Phe Cys Asp  Thr Ile Ala 
    1070                 1075                 1080             


Ala Tyr  Ala His Val Cys Ala  Gln His Gly Lys Val  Val Thr Trp 
    1085                 1090                 1095             


Arg Thr  Ala Thr Leu Cys Pro  Gln Ser Cys Glu Glu  Arg Asn Leu 
    1100                 1105                 1110             


Arg Glu  Asn Gly Tyr Glu Cys  Glu Trp Arg Tyr Asn  Ser Cys Ala 
    1115                 1120                 1125             


Pro Ala  Cys Gln Val Thr Cys  Gln His Pro Glu Pro  Leu Ala Cys 
    1130                 1135                 1140             


Pro Val  Gln Cys Val Glu Gly  Cys His Ala His Cys  Pro Pro Gly 
    1145                 1150                 1155             


Lys Ile  Leu Asp Glu Leu Leu  Gln Thr Cys Val Asp  Pro Glu Asp 
    1160                 1165                 1170             


Cys Pro  Val Cys Glu Val Ala  Gly Arg Arg Phe Ala  Ser Gly Lys 
    1175                 1180                 1185             


Lys Val  Thr Leu Asn Pro Ser  Asp Pro Glu His Cys  Gln Ile Cys 
    1190                 1195                 1200             


His Cys  Asp Val Val Asn Leu  Thr Cys Glu Ala Cys  Gln Glu Pro 
    1205                 1210                 1215             


Gly Gly  Leu Val Val Pro Pro  Thr Asp Ala Pro Val  Ser Pro Thr 
    1220                 1225                 1230             


Thr Leu  Tyr Val Glu Asp Ile  Ser Glu Pro Pro Leu  His Asp Phe 
    1235                 1240                 1245             


Tyr Cys  Ser Arg Leu Leu Asp  Leu Val Phe Leu Leu  Asp Gly Ser 
    1250                 1255                 1260             


Ser Arg  Leu Ser Glu Ala Glu  Phe Glu Val Leu Lys  Ala Phe Val 
    1265                 1270                 1275             


Val Asp  Met Met Glu Arg Leu  Arg Ile Ser Gln Lys  Trp Val Arg 
    1280                 1285                 1290             


Val Ala  Val Val Glu Tyr His  Asp Gly Ser His Ala  Tyr Ile Gly 
    1295                 1300                 1305             


Leu Lys  Asp Arg Lys Arg Pro  Ser Glu Leu Arg Arg  Ile Ala Ser 
    1310                 1315                 1320             


Gln Val  Lys Tyr Ala Gly Ser  Gln Val Ala Ser Thr  Ser Glu Val 
    1325                 1330                 1335             


Leu Lys  Tyr Thr Leu Phe Gln  Ile Phe Ser Lys Ile  Asp Arg Pro 
    1340                 1345                 1350             


Glu Ala  Ser Arg Ile Thr Leu  Leu Leu Met Ala Ser  Gln Glu Pro 
    1355                 1360                 1365             


Gln Arg  Met Ser Arg Asn Phe  Val Arg Tyr Val Gln  Gly Leu Lys 
    1370                 1375                 1380             


Lys Lys  Lys Val Ile Val Ile  Pro Val Gly Ile Gly  Pro His Ala 
    1385                 1390                 1395             


Asn Leu  Lys Gln Ile Arg Leu  Ile Glu Lys Gln Ala  Pro Glu Asn 
    1400                 1405                 1410             


Lys Ala  Phe Val Leu Ser Ser  Val Asp Glu Leu Glu  Gln Gln Arg 
    1415                 1420                 1425             


Asp Glu  Ile Val Ser Tyr Leu  Cys Asp Leu Ala Pro  Glu Ala Pro 
    1430                 1435                 1440             


Pro Pro  Thr Leu Pro Pro Asp  Met Ala Gln Val Thr  Val Gly Pro 
    1445                 1450                 1455             


Gly Leu  Leu Gly Val Ser Thr  Leu Gly Pro Lys Arg  Asn Ser Met 
    1460                 1465                 1470             


Val Leu  Asp Val Ala Phe Val  Leu Glu Gly Ser Asp  Lys Ile Gly 
    1475                 1480                 1485             


Glu Ala  Asp Phe Asn Arg Ser  Lys Glu Phe Met Glu  Glu Val Ile 
    1490                 1495                 1500             


Gln Arg  Met Asp Val Gly Gln  Asp Ser Ile His Val  Thr Val Leu 
    1505                 1510                 1515             


Gln Tyr  Ser Tyr Met Val Thr  Val Glu Tyr Pro Phe  Ser Glu Ala 
    1520                 1525                 1530             


Gln Ser  Lys Gly Asp Ile Leu  Gln Arg Val Arg Glu  Ile Arg Tyr 
    1535                 1540                 1545             


Gln Gly  Gly Asn Arg Thr Asn  Thr Gly Leu Ala Leu  Arg Tyr Leu 
    1550                 1555                 1560             


Ser Asp  His Ser Phe Leu Val  Ser Gln Gly Asp Arg  Glu Gln Ala 
    1565                 1570                 1575             


Pro Asn  Leu Val Tyr Met Val  Thr Gly Asn Pro Ala  Ser Asp Glu 
    1580                 1585                 1590             


Ile Lys  Arg Leu Pro Gly Asp  Ile Gln Val Val Pro  Ile Gly Val 
    1595                 1600                 1605             


Gly Pro  Asn Ala Asn Val Gln  Glu Leu Glu Arg Ile  Gly Trp Pro 
    1610                 1615                 1620             


Asn Ala  Pro Ile Leu Ile Gln  Asp Phe Glu Thr Leu  Pro Arg Glu 
    1625                 1630                 1635             


Ala Pro  Asp Leu Val Leu Gln  Arg Cys Cys Ser Gly  Glu Gly Leu 
    1640                 1645                 1650             


Gln Ile  Pro Thr Leu Ser Pro  Ala Pro Asp Cys Ser  Gln Pro Leu 
    1655                 1660                 1665             


Asp Val  Ile Leu Leu Leu Asp  Gly Ser Ser Ser Phe  Pro Ala Ser 
    1670                 1675                 1680             


Tyr Phe  Asp Glu Met Lys Ser  Phe Ala Lys Ala Phe  Ile Ser Lys 
    1685                 1690                 1695             


Ala Asn  Ile Gly Pro Arg Leu  Thr Gln Val Ser Val  Leu Gln Tyr 
    1700                 1705                 1710             


Gly Ser  Ile Thr Thr Ile Asp  Val Pro Trp Asn Val  Val Pro Glu 
    1715                 1720                 1725             


Lys Ala  His Leu Leu Ser Leu  Val Asp Val Met Gln  Arg Glu Gly 
    1730                 1735                 1740             


Gly Pro  Ser Gln Ile Gly Asp  Ala Leu Gly Phe Ala  Val Arg Tyr 
    1745                 1750                 1755             


Leu Thr  Ser Glu Met His Gly  Ala Arg Pro Gly Ala  Ser Lys Ala 
    1760                 1765                 1770             


Val Val  Ile Leu Val Thr Asp  Val Ser Val Asp Ser  Val Asp Ala 
    1775                 1780                 1785             


Ala Ala  Asp Ala Ala Arg Ser  Asn Arg Val Thr Val  Phe Pro Ile 
    1790                 1795                 1800             


Gly Ile  Gly Asp Arg Tyr Asp  Ala Ala Gln Leu Arg  Ile Leu Ala 
    1805                 1810                 1815             


Gly Pro  Ala Gly Asp Ser Asn  Val Val Lys Leu Gln  Arg Ile Glu 
    1820                 1825                 1830             


Asp Leu  Pro Thr Met Val Thr  Leu Gly Asn Ser Phe  Leu His Lys 
    1835                 1840                 1845             


Leu Cys  Ser Gly Phe Val Arg  Ile Cys Met Asp Glu  Asp Gly Asn 
    1850                 1855                 1860             


Glu Lys  Arg Pro Gly Asp Val  Trp Thr Leu Pro Asp  Gln Cys His 
    1865                 1870                 1875             


Thr Val  Thr Cys Gln Pro Asp  Gly Gln Thr Leu Leu  Lys Ser His 
    1880                 1885                 1890             


Arg Val  Asn Cys Asp Arg Gly  Leu Arg Pro Ser Cys  Pro Asn Ser 
    1895                 1900                 1905             


Gln Ser  Pro Val Lys Val Glu  Glu Thr Cys Gly Cys  Arg Trp Thr 
    1910                 1915                 1920             


Cys Pro  Cys Val Cys Thr Gly  Ser Ser Thr Arg His  Ile Val Thr 
    1925                 1930                 1935             


Phe Asp  Gly Gln Asn Phe Lys  Leu Thr Gly Ser Cys  Ser Tyr Val 
    1940                 1945                 1950             


Leu Phe  Gln Asn Lys Glu Gln  Asp Leu Glu Val Ile  Leu His Asn 
    1955                 1960                 1965             


Gly Ala  Cys Ser Pro Gly Ala  Arg Gln Gly Cys Met  Lys Ser Ile 
    1970                 1975                 1980             


Glu Val  Lys His Ser Ala Leu  Ser Val Glu Leu His  Ser Asp Met 
    1985                 1990                 1995             


Glu Val  Thr Val Asn Gly Arg  Leu Val Ser Val Pro  Tyr Val Gly 
    2000                 2005                 2010             


Gly Asn  Met Glu Val Asn Val  Tyr Gly Ala Ile Met  His Glu Val 
    2015                 2020                 2025             


Arg Phe  Asn His Leu Gly His  Ile Phe Thr Phe Thr  Pro Gln Asn 
    2030                 2035                 2040             


Asn Glu  Phe Gln Leu Gln Leu  Ser Pro Lys Thr Phe  Ala Ser Lys 
    2045                 2050                 2055             


Thr Tyr  Gly Leu Cys Gly Ile  Cys Asp Glu Asn Gly  Ala Asn Asp 
    2060                 2065                 2070             


Phe Met  Leu Arg Asp Gly Thr  Val Thr Thr Asp Trp  Lys Thr Leu 
    2075                 2080                 2085             


Val Gln  Glu Trp Thr Val Gln  Arg Pro Gly Gln Thr  Cys Gln Pro 
    2090                 2095                 2100             


Ile Leu  Glu Glu Gln Cys Leu  Val Pro Asp Ser Ser  His Cys Gln 
    2105                 2110                 2115             


Val Leu  Leu Leu Pro Leu Phe  Ala Glu Cys His Lys  Val Leu Ala 
    2120                 2125                 2130             


Pro Ala  Thr Phe Tyr Ala Ile  Cys Gln Gln Asp Ser  Cys His Gln 
    2135                 2140                 2145             


Glu Gln  Val Cys Glu Val Ile  Ala Ser Tyr Ala His  Leu Cys Arg 
    2150                 2155                 2160             


Thr Asn  Gly Val Cys Val Asp  Trp Arg Thr Pro Asp  Phe Cys Ala 
    2165                 2170                 2175             


Met Ser  Cys Pro Pro Ser Leu  Val Tyr Asn His Cys  Glu His Gly 
    2180                 2185                 2190             


Cys Pro  Arg His Cys Asp Gly  Asn Val Ser Ser Cys  Gly Asp His 
    2195                 2200                 2205             


Pro Ser  Glu Gly Cys Phe Cys  Pro Pro Asp Lys Val  Met Leu Glu 
    2210                 2215                 2220             


Gly Ser  Cys Val Pro Glu Glu  Ala Cys Thr Gln Cys  Ile Gly Glu 
    2225                 2230                 2235             


Asp Gly  Val Gln His Gln Phe  Leu Glu Ala Trp Val  Pro Asp His 
    2240                 2245                 2250             


Gln Pro  Cys Gln Ile Cys Thr  Cys Leu Ser Gly Arg  Lys Val Asn 
    2255                 2260                 2265             


Cys Thr  Thr Gln Pro Cys Pro  Thr Ala Lys Ala Pro  Thr Cys Gly 
    2270                 2275                 2280             


Leu Cys  Glu Val Ala Arg Leu  Arg Gln Asn Ala Asp  Gln Cys Cys 
    2285                 2290                 2295             


Pro Glu  Tyr Glu Cys Val Cys  Asp Pro Val Ser Cys  Asp Leu Pro 
    2300                 2305                 2310             


Pro Val  Pro His Cys Glu Arg  Gly Leu Gln Pro Thr  Leu Thr Asn 
    2315                 2320                 2325             


Pro Gly  Glu Cys Arg Pro Asn  Phe Thr Cys Ala Cys  Arg Lys Glu 
    2330                 2335                 2340             


Glu Cys  Lys Arg Val Ser Pro  Pro Ser Cys Pro Pro  His Arg Leu 
    2345                 2350                 2355             


Pro Thr  Leu Arg Lys Thr Gln  Cys Cys Asp Glu Tyr  Glu Cys Ala 
    2360                 2365                 2370             


Cys Asn  Cys Val Asn Ser Thr  Val Ser Cys Pro Leu  Gly Tyr Leu 
    2375                 2380                 2385             


Ala Ser  Thr Ala Thr Asn Asp  Cys Gly Cys Thr Thr  Thr Thr Cys 
    2390                 2395                 2400             


Leu Pro  Asp Lys Val Cys Val  His Arg Ser Thr Ile  Tyr Pro Val 
    2405                 2410                 2415             


Gly Gln  Phe Trp Glu Glu Gly  Cys Asp Val Cys Thr  Cys Thr Asp 
    2420                 2425                 2430             


Met Glu  Asp Ala Val Met Gly  Leu Arg Val Ala Gln  Cys Ser Gln 
    2435                 2440                 2445             


Lys Pro  Cys Glu Asp Ser Cys  Arg Ser Gly Phe Thr  Tyr Val Leu 
    2450                 2455                 2460             


His Glu  Gly Glu Cys Cys Gly  Arg Cys Leu Pro Ser  Ala Cys Glu 
    2465                 2470                 2475             


Val Val  Thr Gly Ser Pro Arg  Gly Asp Ser Gln Ser  Ser Trp Lys 
    2480                 2485                 2490             


Ser Val  Gly Ser Gln Trp Ala  Ser Pro Glu Asn Pro  Cys Leu Ile 
    2495                 2500                 2505             


Asn Glu  Cys Val Arg Val Lys  Glu Glu Val Phe Ile  Gln Gln Arg 
    2510                 2515                 2520             


Asn Val  Ser Cys Pro Gln Leu  Glu Val Pro Val Cys  Pro Ser Gly 
    2525                 2530                 2535             


Phe Gln  Leu Ser Cys Lys Thr  Ser Ala Cys Cys Pro  Ser Cys Arg 
    2540                 2545                 2550             


Cys Glu  Arg Met Glu Ala Cys  Met Leu Asn Gly Thr  Val Ile Gly 
    2555                 2560                 2565             


Pro Gly  Lys Thr Val Met Ile  Asp Val Cys Thr Thr  Cys Arg Cys 
    2570                 2575                 2580             


Met Val  Gln Val Gly Val Ile  Ser Gly Phe Lys Leu  Glu Cys Arg 
    2585                 2590                 2595             


Lys Thr  Thr Cys Asn Pro Cys  Pro Leu Gly Tyr Lys  Glu Glu Asn 
    2600                 2605                 2610             


Asn Thr  Gly Glu Cys Cys Gly  Arg Cys Leu Pro Thr  Ala Cys Thr 
    2615                 2620                 2625             


Ile Gln  Leu Arg Gly Gly Gln  Ile Met Thr Leu Lys  Arg Asp Glu 
    2630                 2635                 2640             


Thr Leu  Gln Asp Gly Cys Asp  Thr His Phe Cys Lys  Val Asn Glu 
    2645                 2650                 2655             


Arg Gly  Glu Tyr Phe Trp Glu  Lys Arg Val Thr Gly  Cys Pro Pro 
    2660                 2665                 2670             


Phe Asp  Glu His Lys Cys Leu  Ala Glu Gly Gly Lys  Ile Met Lys 
    2675                 2680                 2685             


Ile Pro  Gly Thr Cys Cys Asp  Thr Cys Glu Glu Pro  Glu Cys Asn 
    2690                 2695                 2700             


Asp Ile  Thr Ala Arg Leu Gln  Tyr Val Lys Val Gly  Ser Cys Lys 
    2705                 2710                 2715             


Ser Glu  Val Glu Val Asp Ile  His Tyr Cys Gln Gly  Lys Cys Ala 
    2720                 2725                 2730             


Ser Lys  Ala Met Tyr Ser Ile  Asp Ile Asn Asp Val  Gln Asp Gln 
    2735                 2740                 2745             


Cys Ser  Cys Cys Ser Pro Thr  Arg Thr Glu Pro Met  Gln Val Ala 
    2750                 2755                 2760             


Leu His  Cys Thr Asn Gly Ser  Val Val Tyr His Glu  Val Leu Asn 
    2765                 2770                 2775             


Ala Met  Glu Cys Lys Cys Ser  Pro Arg Lys Cys Ser  Lys 
    2780                 2785                 2790     


