                               SEQUENCE LISTING

<110> TENZA, INC.
 
<120> SYNTHETIC SIGNAL PEPTIDES FOR DIRECTING SECRETION OF HETEROLOGOUS
      PROTEINS IN YEAST

<130> 257723.000402

<140> PCT/US2022/019962
<141> 2022-03-11

<150> 63/221,041
<151> 2021-07-13

<150> 63/159,843
<151> 2021-03-11

<160> 106    

<170> PatentIn version 3.5

<210> 1
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1
Met Lys Leu Ser Ser Leu Leu Leu Leu Leu Leu Leu Leu Leu Ser Ser 
1               5                   10                  15      


Leu Val Leu Ala Ala 
            20      


<210> 2
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 2
Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala 
            


<210> 3
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Met Phe Ser Pro Ile Leu Ser Leu Glu Ile Ile Leu Ala Leu Ala Thr 
1               5                   10                  15      


Leu Gln Ser Val Phe Ala Arg 
            20              


<210> 4
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (21)..(21)
<223> A or absent

<220>
<221> MOD_RES
<222> (22)..(22)
<223> S or absent

<220>
<221> SITE
<222> (21)..(22) 
<223> This region may encompass 0-2 residues

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 4
Met Lys Leu Ser Thr Leu Leu Leu Thr Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Leu Val Leu Ala Xaa Xaa 
            20          


<210> 5
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Met Leu Lys Leu Leu Leu Leu Ile Leu Leu Leu Leu Leu Leu Val Ser 
1               5                   10                  15      


Leu Val Leu Ala Ala Ser 
            20          


<210> 6
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (23)..(23)
<223> A or absent

<220>
<221> MOD_RES
<222> (24)..(24)
<223> S or absent

<220>
<221> SITE
<222> (23)..(24) 
<223> This region may encompass 0-2 residues

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 6
Met Lys Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ala Leu Val Leu Ala Xaa Xaa 
            20                  


<210> 7
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Met Lys Leu Leu Leu Leu Leu Leu Ser Leu Val Leu Ala Ala Ser 
1               5                   10                  15  


<210> 8
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Met Lys Leu Ser Ser Leu Leu Leu Ala Leu Leu Leu Ala Leu Ala 
1               5                   10                  15  


<210> 9
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (21)..(21)
<223> A or absent

<220>
<221> MOD_RES
<222> (22)..(22)
<223> P or absent

<220>
<221> SITE
<222> (21)..(22) 
<223> This region may encompass 0-2 residues

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 9
Met Lys Leu Ser Ser Leu Leu Leu Ala Leu Leu Leu Ala Leu Ala Ser 
1               5                   10                  15      


Leu Ala Leu Ala Xaa Xaa 
            20          


<210> 10
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (23)..(23)
<223> K or absent

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 10
Met Lys Leu Ser Ser Leu Leu Leu Ala Leu Leu Leu Ala Leu Ala Ser 
1               5                   10                  15      


Leu Ala Leu Ala Ala Pro Xaa 
            20              


<210> 11
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Met Lys Leu Lys Thr Val Arg Ser Ala Val Leu Ser Ser Leu Phe Ala 
1               5                   10                  15      


Ser Gln Val Leu Gly 
            20      


<210> 12
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Met Lys Phe Leu Ser Leu Leu Leu Ala Leu Val Ala Ala Leu Ala Leu 
1               5                   10                  15      


Ala Leu Ala Leu Ala Ala Pro 
            20              


<210> 13
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Met Leu Leu Gln Ala Phe Leu Phe Leu Leu Ala Gly Phe Ala Ala Lys 
1               5                   10                  15      


Ile Ser Ala 
            


<210> 14
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Met Lys Phe Lys Leu Thr Leu Leu Ala Ala Leu Leu Ala Leu Ala Ala 
1               5                   10                  15      


Leu Val Leu Ala Ala Ser 
            20          


<210> 15
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Met Lys Leu Ser Ser Ile Leu Leu Leu Leu Ala Leu Leu Ala Leu Val 
1               5                   10                  15      


Leu Ala Ala Ser 
            20  


<210> 16
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Met Lys Leu Leu Ser Leu Leu Ala Leu Leu Leu Leu Leu Ala Ser Leu 
1               5                   10                  15      


Val Leu Ala Ala Ser 
            20      


<210> 17
<211> 67
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln Ile Pro Ala 
1               5                   10                  15      


Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp Phe Asp Val Ala 
            20                  25                  30          


Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu Phe Ile Asn 
        35                  40                  45              


Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val Ser Leu Glu 
    50                  55                  60                  


Lys Arg Glu 
65          


<210> 18
<211> 77
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (69)..(69)
<223> D or absent

<220>
<221> MOD_RES
<222> (70)..(70)
<223> K or absent

<220>
<221> MOD_RES
<222> (71)..(71)
<223> R or absent

<220>
<221> MOD_RES
<222> (72)..(72)
<223> E or absent

<220>
<221> MOD_RES
<222> (73)..(73)
<223> E or absent

<220>
<221> MOD_RES
<222> (74)..(74)
<223> G or absent

<220>
<221> MOD_RES
<222> (75)..(75)
<223> E or absent

<220>
<221> MOD_RES
<222> (76)..(76)
<223> P or absent

<220>
<221> MOD_RES
<222> (77)..(77)
<223> K or absent

<220>
<221> SITE
<222> (69)..(77) 
<223> This region may encompass 0-9 residues

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 18
Ser Leu Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr 
1               5                   10                  15      


Ala Gln Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly 
            20                  25                  30          


Asp Phe Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly 
        35                  40                  45              


Leu Leu Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu 
    50                  55                  60                  


Gly Val Ser Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75          


<210> 19
<211> 50
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (43)..(43)
<223> K or absent

<220>
<221> MOD_RES
<222> (44)..(44)
<223> R or absent

<220>
<221> MOD_RES
<222> (45)..(45)
<223> E or absent

<220>
<221> MOD_RES
<222> (46)..(46)
<223> E or absent

<220>
<221> MOD_RES
<222> (47)..(47)
<223> G or absent

<220>
<221> MOD_RES
<222> (48)..(48)
<223> E or absent

<220>
<221> MOD_RES
<222> (49)..(49)
<223> P or absent

<220>
<221> MOD_RES
<222> (50)..(50)
<223> K or absent

<220>
<221> SITE
<222> (43)..(44) 
<223> This region may encompass 0-2 residues

<220>
<221> SITE
<222> (45)..(50) 
<223> This region may encompass 0-6 residues

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 19
Gln Pro Ile Asp Asp Thr Glu Ser Gln Thr Thr Ser Val Asn Leu Met 
1               5                   10                  15      


Ala Asp Asp Thr Glu Ser Ala Phe Ala Thr Gln Thr Asn Ser Gly Gly 
            20                  25                  30          


Leu Asp Val Val Gly Leu Ile Ser Met Ala Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa 
    50  


<210> 20
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (20)..(20)
<223> K or absent

<220>
<221> MOD_RES
<222> (21)..(21)
<223> R or absent

<220>
<221> MOD_RES
<222> (22)..(22)
<223> E or absent

<220>
<221> MOD_RES
<222> (23)..(23)
<223> E or absent

<220>
<221> MOD_RES
<222> (24)..(24)
<223> G or absent

<220>
<221> MOD_RES
<222> (25)..(25)
<223> E or absent

<220>
<221> MOD_RES
<222> (26)..(26)
<223> P or absent

<220>
<221> MOD_RES
<222> (27)..(27)
<223> K or absent

<220>
<221> SITE
<222> (20)..(27) 
<223> This region may encompass 0-8 residues

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 20
Ile Pro Leu Val Ala Asn Val Ser Phe Asn Ser Asp Asn Gly Ser Gln 
1               5                   10                  15      


Trp Leu Tyr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25          


<210> 21
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (20)..(20)
<223> K or absent

<220>
<221> MOD_RES
<222> (21)..(21)
<223> R or absent

<220>
<221> MOD_RES
<222> (22)..(22)
<223> D or absent

<220>
<221> MOD_RES
<222> (23)..(23)
<223> V or absent

<220>
<221> MOD_RES
<222> (24)..(24)
<223> V or absent

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Y or absent

<220>
<221> MOD_RES
<222> (26)..(26)
<223> P or absent

<220>
<221> MOD_RES
<222> (27)..(27)
<223> K or absent

<220>
<221> SITE
<222> (20)..(27) 
<223> This region may encompass 0-8 residues

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 21
Ile Pro Leu Val Ala Asn Val Ser Phe Asn Ser Asp Asn Gly Ser Gln 
1               5                   10                  15      


Trp Leu Tyr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25          


<210> 22
<211> 42
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Glu Pro Trp Ser Thr Leu Thr Val Thr Arg Ser Thr Tyr Asp Glu Ile 
1               5                   10                  15      


Thr Asp Thr Asp Tyr Asn Ser Thr Gly Ile Ala Val Asn Pro Tyr Thr 
            20                  25                  30          


Val Ser Ala Ser Arg His Lys Arg Asp Val 
        35                  40          


<210> 23
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Ser Thr Leu Thr Pro Ser Val Val Phe Ile Gly Gly Gly Leu Thr Glu 
1               5                   10                  15      


Glu Thr Thr Phe Gly Ile Arg His Lys Arg Asp Val 
            20                  25              


<210> 24
<211> 42
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Asp Pro Trp Ser Thr Thr Thr Ser Ile Tyr Ser Leu Gly Gly Thr Thr 
1               5                   10                  15      


Ser Tyr Val Ser Glu Phe Gly Leu Ser Ile Ser Asp Glu Thr Val Thr 
            20                  25                  30          


Glu Met Lys Ser Arg His Lys Arg Asp Val 
        35                  40          


<210> 25
<211> 72
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (64)..(64)
<223> D or absent

<220>
<221> MOD_RES
<222> (65)..(65)
<223> K or absent

<220>
<221> MOD_RES
<222> (66)..(66)
<223> R or absent

<220>
<221> MOD_RES
<222> (67)..(67)
<223> E or absent

<220>
<221> MOD_RES
<222> (68)..(68)
<223> E or absent

<220>
<221> MOD_RES
<222> (69)..(69)
<223> G or absent

<220>
<221> MOD_RES
<222> (70)..(70)
<223> E or absent

<220>
<221> MOD_RES
<222> (71)..(71)
<223> P or absent

<220>
<221> MOD_RES
<222> (72)..(72)
<223> K or absent

<220>
<221> SITE
<222> (64)..(72) 
<223> This region may encompass 0-9 residues

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 25
Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln Ile Pro Ala 
1               5                   10                  15      


Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp Phe Asp Val Ala 
            20                  25                  30          


Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu Phe Ile Asn 
        35                  40                  45              


Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val Ser Leu Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70          


<210> 26
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 26
Phe Cys Thr Phe Phe Glu Lys His His Arg Lys Trp Asp Ile Leu Leu 
1               5                   10                  15      


Glu Lys Ser Thr Gly Val Met Glu Ala 
            20                  25  


<210> 27
<211> 68
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (64)..(64)
<223> D or absent

<220>
<221> MOD_RES
<222> (65)..(65)
<223> K or E or absent

<220>
<221> MOD_RES
<222> (66)..(66)
<223> R or K or absent

<220>
<221> MOD_RES
<222> (67)..(67)
<223> R or absent

<220>
<221> MOD_RES
<222> (68)..(68)
<223> E or absent

<220>
<221> SITE
<222> (64)..(68) 
<223> This region may encompass 0-5 residues

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 27
Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln Ile Pro Ala 
1               5                   10                  15      


Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp Phe Asp Val Ala 
            20                  25                  30          


Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu Phe Ile Asn 
        35                  40                  45              


Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val Ser Leu Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa 
65              


<210> 28
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 28
Met Lys Phe Ser Thr Ile Leu Ala Ala Ser Thr Ala Leu Ile Ser Val 
1               5                   10                  15      


Val Met Ala 
            


<210> 29
<211> 64
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
Ala Pro Val Ser Thr Glu Thr Asp Ile Asp Asp Leu Pro Ile Ser Val 
1               5                   10                  15      


Pro Glu Glu Ala Leu Ile Gly Phe Ile Asp Leu Thr Gly Asp Glu Val 
            20                  25                  30          


Ser Leu Leu Pro Val Asn Asn Gly Thr His Thr Gly Ile Leu Phe Leu 
        35                  40                  45              


Asn Thr Thr Ile Ala Glu Ala Ala Phe Ala Asp Lys Asp Asp Leu Glu 
    50                  55                  60                  


<210> 30
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Met Phe Ser Pro Ile Leu Ser Leu Glu Ile Ile Leu Ala Leu Ala Thr 
1               5                   10                  15      


Leu Gln Ser Val Phe Ala Arg 
            20              


<210> 31
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (20)..(20)
<223> A or absent

<220>
<221> MOD_RES
<222> (21)..(21)
<223> P or absent

<220>
<221> SITE
<222> (20)..(21) 
<223> This region may encompass 0-2 residues

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 31
Met Lys Ser Ser Leu Leu Leu Leu Ala Leu Leu Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Ser Ala Xaa Xaa 
            20      


<210> 32
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (19)..(19)
<223> A or absent

<220>
<221> MOD_RES
<222> (20)..(20)
<223> P or absent

<220>
<221> SITE
<222> (19)..(20) 
<223> This region may encompass 0-2 residues

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 32
Met Lys Ser Ser Leu Leu Leu Leu Leu Leu Ala Leu Ala Ser Leu Ala 
1               5                   10                  15      


Leu Ala Xaa Xaa 
            20  


<210> 33
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (22)..(22)
<223> A or absent

<220>
<221> MOD_RES
<222> (23)..(23)
<223> P or absent

<220>
<221> SITE
<222> (22)..(23) 
<223> This region may encompass 0-2 residues

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 33
Met Lys Ser Ser Ser Leu Leu Leu Leu Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Ala Ser Ala Xaa Xaa 
            20              


<210> 34
<211> 48
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Glu Ala Arg Asp Ser Trp Ala Ser Pro Gly Gly Gln Ser Thr Arg Ala 
1               5                   10                  15      


Asp Asp Ala Ile Asn Val Ala Gly Thr Gly Gly Ser Ile Leu Arg Pro 
            20                  25                  30          


Ala Lys Phe Ser Thr Leu Asp Ser Arg Arg Ser Lys Arg Ser Ser Glu 
        35                  40                  45              


<210> 35
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 35
Pro Ser Val Arg Pro Pro Val Ala Ser Arg Asp Tyr Ser His Ser Ala 
1               5                   10                  15      


Arg Trp Ser Thr Lys Lys Arg Ser Arg Arg 
            20                  25      


<210> 36
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 36
Leu His Val Phe Ser Thr Asp Tyr Leu Leu Ile Tyr Ile Val Gly Asp 
1               5                   10                  15      


Leu Pro Arg Arg Val Lys Arg Ser Val 
            20                  25  


<210> 37
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 37
Ser Leu Ser Pro Val Asp Asn Ile Leu Leu Leu Gln Leu Leu Gly Thr 
1               5                   10                  15      


Ala Ala Ala Val Leu Ile Gly Ala Ser Lys Asn Asp Gly Gly Val Thr 
            20                  25                  30          


Arg Val Glu Asp Arg Ser Tyr Ser Glu Ile Leu Phe Ser Leu Asn Pro 
        35                  40                  45              


Leu Ser Asp Thr Arg Leu Arg Leu Lys His Val Val Ala Val Ala Gly 
    50                  55                  60                  


Gly Lys Ala Ser Ser Val Thr Asp Tyr Tyr Leu Ser Leu Ser Arg Asn 
65                  70                  75                  80  


Val Pro Glu Gly Val Trp Tyr Met Ala Thr Ser Ile Asp Gly Glu Ile 
                85                  90                  95      


Ala Trp Leu Gly Leu Ile Ala Asp Val Leu Arg Gly Val Phe Leu Leu 
            100                 105                 110         


Gly Glu Ala Ala Arg Glu Ser Val 
        115                 120 


<210> 38
<211> 96
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Ser Tyr Ser Arg Val Ser Asn Ala Ala Gly Lys Ser Arg Gly Asp Cys 
1               5                   10                  15      


Arg Ser Arg Leu Phe Pro Asp Gly Thr Lys Ser Pro Pro Ser Ala Ser 
            20                  25                  30          


Pro Arg Arg Glu Ala Arg Arg Asp Ser Leu His Pro Val Leu Thr Ser 
        35                  40                  45              


Ser Ala Glu Ser Gly Ser Gly Ser Tyr Met Ser Ser Asn Ser Ala Arg 
    50                  55                  60                  


Asp Leu Leu Arg Ser Gly Ala Lys Asn His Leu Gly Ala Pro Asn Asn 
65                  70                  75                  80  


Asp Gln Val Lys Phe Gly Leu Ala Thr Arg Thr Arg Lys Arg Ala Glu 
                85                  90                  95      


<210> 39
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 39
atgaaattgt cttctttgtt gttgttgttg ttgttgttgt tgtcttcttt ggttttgct        59


<210> 40
<211> 69
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 40
atgttctctc caattttgtc cttggaaatt attttagctt tggctacttt gcaatctgtc       60

ttcgctcga                                                               69


<210> 41
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 41
atgaaattgt ctactctgtt gttgactttg ttgttgttgt tgttggcttt ggttttggct       60

gcttct                                                                  66


<210> 42
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 42
atgttgaaat tgttgctgtt gattttgttg ttgttgcttt tggtttcttt ggttttggct       60

gcttct                                                                  66


<210> 43
<211> 72
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 43
atgaaattgt tactgctttt acttcttttg ctgttattgt tgcttttgct ggctttggtt       60

ttggctgctt ct                                                           72


<210> 44
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 44
atgaaattgt tgttgttgtt gttgtctttg gttttggctg cttct                       45


<210> 45
<211> 69
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 45
atgttctctc caattttgtc cttggaaatt attttagctt tggctacttt gcaatctgtc       60

ttcgctcga                                                               69


<210> 46
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 46
atgaagttat cttctttatt gctggctctg cttctagcct tggcg                       45


<210> 47
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 47
atgaagttat cttctttatt gctggctctg cttctagcct tggcgtctct agcgctggcc       60


<210> 48
<211> 69
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 48
atgaagttat cttctttatt gctggctctg cttctagcct tggcgtctct agcgctggcc       60

gcaccaaag                                                               69


<210> 49
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 49
atgaaattga aaactgttag atctgctgtt ttgtcttctt tgtttgcttc tcaagttttg       60

ggt                                                                     63


<210> 50
<211> 201
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 50
gctccagtca acactacaac agaagatgaa acggcacaaa ttccggctga agctgtcatc       60

ggttactcag atttagaagg ggatttcgat gttgctgttt tgccattttc caacagcaca      120

aataacgggt tattgtttat aaatactact attgccagca ttgctgctaa agaagaaggg      180

gtatctctcg agaaaagaga g                                                201


<210> 51
<211> 150
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 51
gctccagtta atactactac tgaagatgaa actgctcaaa ttccagctga agctgttatt       60

ggttattctg atttggaggg tgactttgat gttgctgttt tgccattttc taactctact      120

aacaacggtt tgctattcat caacactact                                       150


<210> 52
<211> 150
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 52
caaccaattg atgatactga atctcaaact acttctgtta atttgatggc tgatgatact       60

gaatctgctt ttgctactca aactaattct ggtggtttgg atgttgttgg tttgatttct      120

atggctaaaa gagaagaagg tgaaccaaaa                                       150


<210> 53
<211> 87
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 53
gctccaattc cattggttgc taatgtttct tttaattctg ataatggttc tcaatggttg       60

tataaaagag aagaaggtga accaaaa                                           87


<210> 54
<211> 87
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 54
gctccaattc cattggttgc taatgtttct tttaattctg ataatggttc tcaatggttg       60

tataaaagag atgttgttta tccaaaa                                           87


<210> 55
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 55
Met Arg Ser Leu Leu Ile Leu Val Leu Cys Phe Leu Pro Leu Ala Ala 
1               5                   10                  15      


Leu Gly 
        


<210> 56
<211> 66
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 56
Ala Pro Val Ser Thr Glu Thr Asp Ile Asp Asp Leu Pro Ile Ser Val 
1               5                   10                  15      


Pro Glu Glu Ala Leu Ile Gly Phe Ile Asp Leu Thr Gly Asp Glu Val 
            20                  25                  30          


Ser Leu Leu Pro Val Asn Asn Gly Thr His Thr Gly Ile Leu Phe Leu 
        35                  40                  45              


Asn Thr Thr Ile Ala Glu Ala Ala Phe Ala Asp Lys Asp Asp Leu Glu 
    50                  55                  60                  


Lys Arg 
65      


<210> 57
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 57
Ala Pro Ile Pro Leu Val Ala Asn Val Ser Phe Asn Ser Asp Asn Gly 
1               5                   10                  15      


Ser Gln Trp Leu Tyr Lys Arg Asp Val Val Tyr Pro Lys 
            20                  25                  


<210> 58
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 58
Ala Pro Ile Pro Leu Val Ala Asn Val Ser Phe Asn Ser Asp Asn Gly 
1               5                   10                  15      


Ser Gln Trp Leu Tyr Lys Arg Glu Glu Gly Glu Pro Lys 
            20                  25                  


<210> 59
<211> 585
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 59
Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln Ile Pro Ala 
1               5                   10                  15      


Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp Phe Asp Val Ala 
            20                  25                  30          


Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu Phe Ile Asn 
        35                  40                  45              


Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val Ser Leu Asp 
    50                  55                  60                  


Lys Arg Glu Glu Gly Glu Pro Lys Ser Met Thr Asn Glu Thr Ser Asp 
65                  70                  75                  80  


Arg Pro Leu Val His Phe Thr Pro Asn Lys Gly Trp Met Asn Asp Pro 
                85                  90                  95      


Asn Gly Leu Trp Tyr Asp Glu Lys Asp Ala Lys Trp His Leu Tyr Phe 
            100                 105                 110         


Gln Tyr Asn Pro Asn Asp Thr Val Trp Gly Thr Pro Leu Phe Trp Gly 
        115                 120                 125             


His Ala Thr Ser Asp Asp Leu Thr Asn Trp Glu Asp Gln Pro Ile Ala 
    130                 135                 140                 


Ile Ala Pro Lys Arg Asn Asp Ser Gly Ala Phe Ser Gly Ser Met Val 
145                 150                 155                 160 


Val Asp Tyr Asn Asn Thr Ser Gly Phe Phe Asn Asp Thr Ile Asp Pro 
                165                 170                 175     


Arg Gln Arg Cys Val Ala Ile Trp Thr Tyr Asn Thr Pro Glu Ser Glu 
            180                 185                 190         


Glu Gln Tyr Ile Ser Tyr Ser Leu Asp Gly Gly Tyr Thr Phe Thr Glu 
        195                 200                 205             


Tyr Gln Lys Asn Pro Val Leu Ala Ala Asn Ser Thr Gln Phe Arg Asp 
    210                 215                 220                 


Pro Lys Val Phe Trp Tyr Glu Pro Ser Gln Lys Trp Ile Met Thr Ala 
225                 230                 235                 240 


Ala Lys Ser Gln Asp Tyr Lys Ile Glu Ile Tyr Ser Ser Asp Asp Leu 
                245                 250                 255     


Lys Ser Trp Lys Leu Glu Ser Ala Phe Ala Asn Glu Gly Phe Leu Gly 
            260                 265                 270         


Tyr Gln Tyr Glu Cys Pro Gly Leu Ile Glu Val Pro Thr Glu Gln Asp 
        275                 280                 285             


Pro Ser Lys Ser Tyr Trp Val Met Phe Ile Ser Ile Asn Pro Gly Ala 
    290                 295                 300                 


Pro Ala Gly Gly Ser Phe Asn Gln Tyr Phe Val Gly Ser Phe Asn Gly 
305                 310                 315                 320 


Thr His Phe Glu Ala Phe Asp Asn Gln Ser Arg Val Val Asp Phe Gly 
                325                 330                 335     


Lys Asp Tyr Tyr Ala Leu Gln Thr Phe Phe Asn Thr Asp Pro Thr Tyr 
            340                 345                 350         


Gly Ser Ala Leu Gly Ile Ala Trp Ala Ser Asn Trp Glu Tyr Ser Ala 
        355                 360                 365             


Phe Val Pro Thr Asn Pro Trp Arg Ser Ser Met Ser Leu Val Arg Lys 
    370                 375                 380                 


Phe Ser Leu Asn Thr Glu Tyr Gln Ala Asn Pro Glu Thr Glu Leu Ile 
385                 390                 395                 400 


Asn Leu Lys Ala Glu Pro Ile Leu Asn Ile Ser Asn Ala Gly Pro Trp 
                405                 410                 415     


Ser Arg Phe Ala Thr Asn Thr Thr Leu Thr Lys Ala Asn Ser Tyr Asn 
            420                 425                 430         


Val Asp Leu Ser Asn Ser Thr Gly Thr Leu Glu Phe Glu Leu Val Tyr 
        435                 440                 445             


Ala Val Asn Thr Thr Gln Thr Ile Ser Lys Ser Val Phe Ala Asp Leu 
    450                 455                 460                 


Ser Leu Trp Phe Lys Gly Leu Glu Asp Pro Glu Glu Tyr Leu Arg Met 
465                 470                 475                 480 


Gly Phe Glu Val Ser Ala Ser Ser Phe Phe Leu Asp Arg Gly Asn Ser 
                485                 490                 495     


Lys Val Lys Phe Val Lys Glu Asn Pro Tyr Phe Thr Asn Arg Met Ser 
            500                 505                 510         


Val Asn Asn Gln Pro Phe Lys Ser Glu Asn Asp Leu Ser Tyr Tyr Lys 
        515                 520                 525             


Val Tyr Gly Leu Leu Asp Gln Asn Ile Leu Glu Leu Tyr Phe Asn Asp 
    530                 535                 540                 


Gly Asp Val Val Ser Thr Asn Thr Tyr Phe Met Thr Thr Gly Asn Ala 
545                 550                 555                 560 


Leu Gly Ser Val Asn Met Thr Thr Gly Val Asp Asn Leu Phe Tyr Ile 
                565                 570                 575     


Asp Lys Phe Gln Val Arg Glu Val Lys 
            580                 585 


<210> 60
<211> 513
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 60
Ser Met Thr Asn Glu Thr Ser Asp Arg Pro Leu Val His Phe Thr Pro 
1               5                   10                  15      


Asn Lys Gly Trp Met Asn Asp Pro Asn Gly Leu Trp Tyr Asp Glu Lys 
            20                  25                  30          


Asp Ala Lys Trp His Leu Tyr Phe Gln Tyr Asn Pro Asn Asp Thr Val 
        35                  40                  45              


Trp Gly Thr Pro Leu Phe Trp Gly His Ala Thr Ser Asp Asp Leu Thr 
    50                  55                  60                  


Asn Trp Glu Asp Gln Pro Ile Ala Ile Ala Pro Lys Arg Asn Asp Ser 
65                  70                  75                  80  


Gly Ala Phe Ser Gly Ser Met Val Val Asp Tyr Asn Asn Thr Ser Gly 
                85                  90                  95      


Phe Phe Asn Asp Thr Ile Asp Pro Arg Gln Arg Cys Val Ala Ile Trp 
            100                 105                 110         


Thr Tyr Asn Thr Pro Glu Ser Glu Glu Gln Tyr Ile Ser Tyr Ser Leu 
        115                 120                 125             


Asp Gly Gly Tyr Thr Phe Thr Glu Tyr Gln Lys Asn Pro Val Leu Ala 
    130                 135                 140                 


Ala Asn Ser Thr Gln Phe Arg Asp Pro Lys Val Phe Trp Tyr Glu Pro 
145                 150                 155                 160 


Ser Gln Lys Trp Ile Met Thr Ala Ala Lys Ser Gln Asp Tyr Lys Ile 
                165                 170                 175     


Glu Ile Tyr Ser Ser Asp Asp Leu Lys Ser Trp Lys Leu Glu Ser Ala 
            180                 185                 190         


Phe Ala Asn Glu Gly Phe Leu Gly Tyr Gln Tyr Glu Cys Pro Gly Leu 
        195                 200                 205             


Ile Glu Val Pro Thr Glu Gln Asp Pro Ser Lys Ser Tyr Trp Val Met 
    210                 215                 220                 


Phe Ile Ser Ile Asn Pro Gly Ala Pro Ala Gly Gly Ser Phe Asn Gln 
225                 230                 235                 240 


Tyr Phe Val Gly Ser Phe Asn Gly Thr His Phe Glu Ala Phe Asp Asn 
                245                 250                 255     


Gln Ser Arg Val Val Asp Phe Gly Lys Asp Tyr Tyr Ala Leu Gln Thr 
            260                 265                 270         


Phe Phe Asn Thr Asp Pro Thr Tyr Gly Ser Ala Leu Gly Ile Ala Trp 
        275                 280                 285             


Ala Ser Asn Trp Glu Tyr Ser Ala Phe Val Pro Thr Asn Pro Trp Arg 
    290                 295                 300                 


Ser Ser Met Ser Leu Val Arg Lys Phe Ser Leu Asn Thr Glu Tyr Gln 
305                 310                 315                 320 


Ala Asn Pro Glu Thr Glu Leu Ile Asn Leu Lys Ala Glu Pro Ile Leu 
                325                 330                 335     


Asn Ile Ser Asn Ala Gly Pro Trp Ser Arg Phe Ala Thr Asn Thr Thr 
            340                 345                 350         


Leu Thr Lys Ala Asn Ser Tyr Asn Val Asp Leu Ser Asn Ser Thr Gly 
        355                 360                 365             


Thr Leu Glu Phe Glu Leu Val Tyr Ala Val Asn Thr Thr Gln Thr Ile 
    370                 375                 380                 


Ser Lys Ser Val Phe Ala Asp Leu Ser Leu Trp Phe Lys Gly Leu Glu 
385                 390                 395                 400 


Asp Pro Glu Glu Tyr Leu Arg Met Gly Phe Glu Val Ser Ala Ser Ser 
                405                 410                 415     


Phe Phe Leu Asp Arg Gly Asn Ser Lys Val Lys Phe Val Lys Glu Asn 
            420                 425                 430         


Pro Tyr Phe Thr Asn Arg Met Ser Val Asn Asn Gln Pro Phe Lys Ser 
        435                 440                 445             


Glu Asn Asp Leu Ser Tyr Tyr Lys Val Tyr Gly Leu Leu Asp Gln Asn 
    450                 455                 460                 


Ile Leu Glu Leu Tyr Phe Asn Asp Gly Asp Val Val Ser Thr Asn Thr 
465                 470                 475                 480 


Tyr Phe Met Thr Thr Gly Asn Ala Leu Gly Ser Val Asn Met Thr Thr 
                485                 490                 495     


Gly Val Asp Asn Leu Phe Tyr Ile Asp Lys Phe Gln Val Arg Glu Val 
            500                 505                 510         


Lys 
    


<210> 61
<211> 130
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 61
Lys Val Phe Glu Arg Cys Glu Leu Ala Arg Thr Leu Lys Arg Leu Gly 
1               5                   10                  15      


Met Asp Gly Tyr Arg Gly Ile Ser Leu Ala Asn Trp Met Cys Leu Ala 
            20                  25                  30          


Lys Trp Glu Ser Gly Tyr Asn Thr Arg Ala Thr Asn Tyr Asn Ala Gly 
        35                  40                  45              


Asp Arg Ser Thr Asp Tyr Gly Ile Phe Gln Ile Asn Ser Arg Tyr Trp 
    50                  55                  60                  


Cys Asn Asp Gly Lys Thr Pro Gly Ala Val Asn Ala Cys Gln Leu Ser 
65                  70                  75                  80  


Cys Ser Ala Leu Leu Gln Asp Asn Ile Ala Asp Ala Val Ala Cys Ala 
                85                  90                  95      


Lys Arg Val Val Arg Asp Pro Gln Gly Ile Arg Ala Trp Val Ala Trp 
            100                 105                 110         


Arg Asn Arg Cys Gln Asn Arg Asp Val Arg Gln Tyr Val Gln Gly Cys 
        115                 120                 125             


Gly Val 
    130 


<210> 62
<211> 985
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 62
Ile Lys His Arg Leu Asn Gly Phe Thr Ile Leu Glu His Pro Asp Pro 
1               5                   10                  15      


Ala Lys Arg Asp Leu Leu Gln Asp Ile Val Thr Trp Asp Asp Lys Ser 
            20                  25                  30          


Leu Phe Ile Asn Gly Glu Arg Ile Met Leu Phe Ser Gly Glu Val His 
        35                  40                  45              


Pro Phe Arg Leu Pro Val Pro Ser Leu Trp Leu Asp Ile Phe His Lys 
    50                  55                  60                  


Ile Arg Ala Leu Gly Phe Asn Cys Val Ser Phe Tyr Ile Asp Trp Ala 
65                  70                  75                  80  


Leu Leu Glu Gly Lys Pro Gly Asp Tyr Arg Ala Glu Gly Ile Phe Ala 
                85                  90                  95      


Leu Glu Pro Phe Phe Asp Ala Ala Lys Glu Ala Gly Ile Tyr Leu Ile 
            100                 105                 110         


Ala Arg Pro Gly Ser Tyr Ile Asn Ala Glu Val Ser Gly Gly Gly Phe 
        115                 120                 125             


Pro Gly Trp Leu Gln Arg Val Asn Gly Thr Leu Arg Ser Ser Asp Glu 
    130                 135                 140                 


Pro Phe Leu Lys Ala Thr Asp Asn Tyr Ile Ala Asn Ala Ala Ala Ala 
145                 150                 155                 160 


Val Ala Lys Ala Gln Ile Thr Asn Gly Gly Pro Val Ile Leu Tyr Gln 
                165                 170                 175     


Pro Glu Asn Glu Tyr Ser Gly Gly Cys Cys Gly Val Lys Tyr Pro Asp 
            180                 185                 190         


Ala Asp Tyr Met Gln Tyr Val Met Asp Gln Ala Arg Lys Ala Asp Ile 
        195                 200                 205             


Val Val Pro Phe Ile Ser Asn Asp Ala Ser Pro Ser Gly His Asn Ala 
    210                 215                 220                 


Pro Gly Ser Gly Thr Ser Ala Val Asp Ile Tyr Gly His Asp Ser Tyr 
225                 230                 235                 240 


Pro Leu Gly Phe Asp Cys Ala Asn Pro Ser Val Trp Pro Glu Gly Lys 
                245                 250                 255     


Leu Pro Asp Asn Phe Arg Thr Leu His Leu Glu Gln Ser Pro Ser Thr 
            260                 265                 270         


Pro Tyr Ser Leu Leu Glu Phe Gln Ala Gly Ala Phe Asp Pro Trp Gly 
        275                 280                 285             


Gly Pro Gly Phe Glu Lys Cys Tyr Ala Leu Val Asn His Glu Phe Ser 
    290                 295                 300                 


Arg Val Phe Tyr Arg Asn Asp Leu Ser Phe Gly Val Ser Thr Phe Asn 
305                 310                 315                 320 


Leu Tyr Met Thr Phe Gly Gly Thr Asn Trp Gly Asn Leu Gly His Pro 
                325                 330                 335     


Gly Gly Tyr Thr Ser Tyr Asp Tyr Gly Ser Pro Ile Thr Glu Thr Arg 
            340                 345                 350         


Asn Val Thr Arg Glu Lys Tyr Ser Asp Ile Lys Leu Leu Ala Asn Phe 
        355                 360                 365             


Val Lys Ala Ser Pro Ser Tyr Leu Thr Ala Thr Pro Arg Asn Leu Thr 
    370                 375                 380                 


Thr Gly Val Tyr Thr Asp Thr Ser Asp Leu Ala Val Thr Pro Leu Ile 
385                 390                 395                 400 


Gly Asp Ser Pro Gly Ser Phe Phe Val Val Arg His Thr Asp Tyr Ser 
                405                 410                 415     


Ser Gln Glu Ser Thr Ser Tyr Lys Leu Lys Leu Pro Thr Ser Ala Gly 
            420                 425                 430         


Asn Leu Thr Ile Pro Gln Leu Glu Gly Thr Leu Ser Leu Asn Gly Arg 
        435                 440                 445             


Asp Ser Lys Ile His Val Val Asp Tyr Asn Val Ser Gly Thr Asn Ile 
    450                 455                 460                 


Ile Tyr Ser Thr Ala Glu Val Phe Thr Trp Lys Lys Phe Asp Gly Asn 
465                 470                 475                 480 


Lys Val Leu Val Leu Tyr Gly Gly Pro Lys Glu His His Glu Leu Ala 
                485                 490                 495     


Ile Ala Ser Lys Ser Asn Val Thr Ile Ile Glu Gly Ser Asp Ser Gly 
            500                 505                 510         


Ile Val Ser Thr Arg Lys Gly Ser Ser Val Ile Ile Gly Trp Asp Val 
        515                 520                 525             


Ser Ser Thr Arg Arg Ile Val Gln Val Gly Asp Leu Arg Val Phe Leu 
    530                 535                 540                 


Leu Asp Arg Asn Ser Ala Tyr Asn Tyr Trp Val Pro Glu Leu Pro Thr 
545                 550                 555                 560 


Glu Gly Thr Ser Pro Gly Phe Ser Thr Ser Lys Thr Thr Ala Ser Ser 
                565                 570                 575     


Ile Ile Val Lys Ala Gly Tyr Leu Leu Arg Gly Ala His Leu Asp Gly 
            580                 585                 590         


Ala Asp Leu His Leu Thr Ala Asp Phe Asn Ala Thr Thr Pro Ile Glu 
        595                 600                 605             


Val Ile Gly Ala Pro Thr Gly Ala Lys Asn Leu Phe Val Asn Gly Glu 
    610                 615                 620                 


Lys Ala Ser His Thr Val Asp Lys Asn Gly Ile Trp Ser Ser Glu Val 
625                 630                 635                 640 


Lys Tyr Ala Ala Pro Glu Ile Lys Leu Pro Gly Leu Lys Asp Leu Asp 
                645                 650                 655     


Trp Lys Tyr Leu Asp Thr Leu Pro Glu Ile Lys Ser Ser Tyr Asp Asp 
            660                 665                 670         


Ser Ala Trp Val Ser Ala Asp Leu Pro Lys Thr Lys Asn Thr His Arg 
        675                 680                 685             


Pro Leu Asp Thr Pro Thr Ser Leu Tyr Ser Ser Asp Tyr Gly Phe His 
    690                 695                 700                 


Thr Gly Tyr Leu Ile Tyr Arg Gly His Phe Val Ala Asn Gly Lys Glu 
705                 710                 715                 720 


Ser Glu Phe Phe Ile Arg Thr Gln Gly Gly Ser Ala Phe Gly Ser Ser 
                725                 730                 735     


Val Trp Leu Asn Glu Thr Tyr Leu Gly Ser Trp Thr Gly Ala Asp Tyr 
            740                 745                 750         


Ala Met Asp Gly Asn Ser Thr Tyr Lys Leu Ser Gln Leu Glu Ser Gly 
        755                 760                 765             


Lys Asn Tyr Val Ile Thr Val Val Ile Asp Asn Leu Gly Leu Asp Glu 
    770                 775                 780                 


Asn Trp Thr Val Gly Glu Glu Thr Met Lys Asn Pro Arg Gly Ile Leu 
785                 790                 795                 800 


Ser Tyr Lys Leu Ser Gly Gln Asp Ala Ser Ala Ile Thr Trp Lys Leu 
                805                 810                 815     


Thr Gly Asn Leu Gly Gly Glu Asp Tyr Gln Asp Lys Val Arg Gly Pro 
            820                 825                 830         


Leu Asn Glu Gly Gly Leu Tyr Ala Glu Arg Gln Gly Phe His Gln Pro 
        835                 840                 845             


Gln Pro Pro Ser Glu Ser Trp Glu Ser Gly Ser Pro Leu Glu Gly Leu 
    850                 855                 860                 


Ser Lys Pro Gly Ile Gly Phe Tyr Thr Ala Gln Phe Asp Leu Asp Leu 
865                 870                 875                 880 


Pro Lys Gly Trp Asp Val Pro Leu Tyr Phe Asn Phe Gly Asn Asn Thr 
                885                 890                 895     


Gln Ala Ala Arg Ala Gln Leu Tyr Val Asn Gly Tyr Gln Tyr Gly Lys 
            900                 905                 910         


Phe Thr Gly Asn Val Gly Pro Gln Thr Ser Phe Pro Val Pro Glu Gly 
        915                 920                 925             


Ile Leu Asn Tyr Arg Gly Thr Asn Tyr Val Ala Leu Ser Leu Trp Ala 
    930                 935                 940                 


Leu Glu Ser Asp Gly Ala Lys Leu Gly Ser Phe Glu Leu Ser Tyr Thr 
945                 950                 955                 960 


Thr Pro Val Leu Thr Gly Tyr Gly Asn Val Glu Ser Pro Glu Gln Pro 
                965                 970                 975     


Lys Tyr Glu Gln Arg Lys Gly Ala Tyr 
            980                 985 


<210> 63
<211> 114
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 63
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Glu Ile Asn Thr Asn Gly Leu Ile Thr Lys Tyr Pro Asp Ser Val 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Pro Ser Gly Phe Asn Arg Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210> 64
<211> 369
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 64
Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys Gly Tyr 
1               5                   10                  15      


Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr Gly Ile 
            20                  25                  30          


Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe Pro Gln 
        35                  40                  45              


Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala His Asp 
    50                  55                  60                  


Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile Thr Pro 
65                  70                  75                  80  


Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp Ala Val 
                85                  90                  95      


Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu Ala Leu 
            100                 105                 110         


Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys Thr Trp 
        115                 120                 125             


Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly Lys Ser 
    130                 135                 140                 


Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro Leu Ile 
145                 150                 155                 160 


Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys Tyr Asp 
                165                 170                 175     


Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly Leu Thr 
            180                 185                 190         


Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp Thr Asp 
        195                 200                 205             


Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala Met Thr 
    210                 215                 220                 


Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys Val Asn 
225                 230                 235                 240 


Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser Lys Pro 
                245                 250                 255     


Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro Asn Lys 
            260                 265                 270         


Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp Glu Gly 
        275                 280                 285             


Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala Leu Lys 
    290                 295                 300                 


Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala Thr Met 
305                 310                 315                 320 


Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln Met Ser 
                325                 330                 335     


Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala Ser Gly 
            340                 345                 350         


Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Arg Ile Thr 
        355                 360                 365             


Lys 
    


<210> 65
<211> 411
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 65
Ala Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser 
1               5                   10                  15      


Arg His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp 
            20                  25                  30          


Val Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Glu Leu 
        35                  40                  45              


Thr Pro Arg Gly Gly Glu Leu Leu Ala Tyr Leu Gly His Tyr Trp Arg 
    50                  55                  60                  


Gln Arg Leu Val Ala Asp Gly Leu Leu Pro Lys Cys Gly Cys Pro Gln 
65                  70                  75                  80  


Ser Gly Gln Val Ala Ile Leu Ala Asp Val Asp Glu Arg Thr Arg Lys 
                85                  90                  95      


Thr Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr 
            100                 105                 110         


Val His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro 
        115                 120                 125             


Leu Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala 
    130                 135                 140                 


Ile Leu Glu Arg Ala Gly Gly Ser Leu Ala Asp Phe Thr Gly His Tyr 
145                 150                 155                 160 


Gln Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser 
                165                 170                 175     


Asn Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr 
            180                 185                 190         


Gln Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Cys Val Ser Leu 
        195                 200                 205             


Thr Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu 
    210                 215                 220                 


Gln Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp 
225                 230                 235                 240 


Ser His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Asp 
                245                 250                 255     


Leu Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu 
            260                 265                 270         


Leu Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln 
        275                 280                 285             


Ala Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Leu Ala Gly His 
    290                 295                 300                 


Asp Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr 
305                 310                 315                 320 


Leu Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe 
                325                 330                 335     


Glu Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser 
            340                 345                 350         


Leu Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser 
        355                 360                 365             


Leu Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu 
    370                 375                 380                 


Glu Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile 
385                 390                 395                 400 


Val Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410     


<210> 66
<211> 53
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 66
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Glu Trp Lys 
            20                  25                  30          


Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
        35                  40                  45              


Glu Asn Tyr Cys Asn 
    50              


<210> 67
<211> 105
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 67
Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Pro Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ile Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Thr Lys Ala Ala Arg Ser Ile Arg Ala Gln Arg His Thr Asp 
65                  70                  75                  80  


Met Pro Lys Thr Gln Lys Glu Val His Leu Lys Asn Thr Ser Arg Gly 
                85                  90                  95      


Ser Ala Gly Asn Lys Thr Tyr Arg Met 
            100                 105 


<210> 68
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 68
Asn Val Ile Ser Lys Arg 
1               5       


<210> 69
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 69
Ser Asp Val Thr Lys Arg 
1               5       


<210> 70
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 70
Met Arg Ser Leu Ser Leu Ala Leu Leu Leu Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ser Leu Ala Leu Ala Ala Pro 
            20              


<210> 71
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 71
Met Arg Leu Ser Leu Ser Leu Leu Leu Leu Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ser Leu Ala Leu Ala Ala Pro 
            20              


<210> 72
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 72
Met Arg Leu Ser Ser Leu Leu Leu Gly Leu Leu Leu Ala Leu Ala Ala 
1               5                   10                  15      


Ser Leu Ala Leu Ala Ala Pro 
            20              


<210> 73
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 73
Met Arg Leu Ser Leu Leu Leu Ala Leu Leu Ala Leu Leu Ala Leu Ala 
1               5                   10                  15      


Ser Leu Ala Leu Ala Ala Pro 
            20              


<210> 74
<211> 67
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 74
Ala Ser Ser Gly Arg Ser Pro Thr Ile Thr Gly Gln Val Ser Thr Leu 
1               5                   10                  15      


Ser Ser Thr Asp Gly Thr Leu Pro Thr Ser Phe Thr Ser Gly Ser Ala 
            20                  25                  30          


Ala Gly Thr Ile Ser Ser Thr Leu Pro Ser Asn Val Thr Ser Thr Leu 
        35                  40                  45              


Gly Thr Ile Asp Leu Ser Pro Asn Gly Ser Ala Asp Ser Ser Ser Lys 
    50                  55                  60                  


Arg Ser Thr 
65          


<210> 75
<211> 73
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 75
Ser Pro Thr Thr Ser Pro Ser Thr Thr Ala Ser Leu Val Ser Thr Ser 
1               5                   10                  15      


Val Thr Ser Ser Val Thr Leu Thr Ser Thr Asp Val Thr Thr Ser Glu 
            20                  25                  30          


Asp Thr Thr Gly Phe Val Leu Pro Asp Ser Gly Thr Ser Ser Gly Thr 
        35                  40                  45              


Ala Asp Ala Leu Glu Ala Tyr Ser Ile Gly Ile Thr Ser Ser Ser Ala 
    50                  55                  60                  


Val Val Asp Ser Lys Lys Arg Asp Ala 
65                  70              


<210> 76
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 76
Met Ser Phe Arg Ser Leu Leu Ala Leu Ser Gly Leu Val Cys Thr Gly 
1               5                   10                  15      


Leu Ala 
        


<210> 77
<211> 640
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 77
Met Ser Phe Arg Ser Leu Leu Ala Leu Ser Gly Leu Val Cys Thr Gly 
1               5                   10                  15      


Leu Ala Asn Val Ile Ser Lys Arg Ala Thr Leu Asp Ser Trp Leu Ser 
            20                  25                  30          


Asn Glu Ala Thr Val Ala Arg Thr Ala Ile Leu Asn Asn Ile Gly Ala 
        35                  40                  45              


Asp Gly Ala Trp Val Ser Gly Ala Asp Ser Gly Ile Val Val Ala Ser 
    50                  55                  60                  


Pro Ser Thr Asp Asn Pro Asp Tyr Phe Tyr Thr Trp Thr Arg Asp Ser 
65                  70                  75                  80  


Gly Leu Val Leu Lys Thr Leu Val Asp Leu Phe Arg Asn Gly Asp Thr 
                85                  90                  95      


Ser Leu Leu Ser Thr Ile Glu Asn Tyr Ile Ser Ala Gln Ala Ile Val 
            100                 105                 110         


Gln Gly Ile Ser Asn Pro Ser Gly Asp Leu Ser Ser Gly Ala Gly Leu 
        115                 120                 125             


Gly Glu Pro Lys Phe Asn Val Asp Glu Thr Ala Tyr Thr Gly Ser Trp 
    130                 135                 140                 


Gly Arg Pro Gln Arg Asp Gly Pro Ala Leu Arg Ala Thr Ala Met Ile 
145                 150                 155                 160 


Gly Phe Gly Gln Trp Leu Leu Asp Asn Gly Tyr Thr Ser Thr Ala Thr 
                165                 170                 175     


Asp Ile Val Trp Pro Leu Val Arg Asn Asp Leu Ser Tyr Val Ala Gln 
            180                 185                 190         


Tyr Trp Asn Gln Thr Gly Tyr Asp Leu Trp Glu Glu Val Asn Gly Ser 
        195                 200                 205             


Ser Phe Phe Thr Ile Ala Val Gln His Arg Ala Leu Val Glu Gly Ser 
    210                 215                 220                 


Ala Phe Ala Thr Ala Val Gly Ser Ser Cys Ser Trp Cys Asp Ser Gln 
225                 230                 235                 240 


Ala Pro Glu Ile Leu Cys Tyr Leu Gln Ser Phe Trp Thr Gly Ser Phe 
                245                 250                 255     


Ile Leu Ala Asn Phe Asp Ser Ser Arg Ser Gly Lys Asp Ala Asn Thr 
            260                 265                 270         


Leu Leu Gly Ser Ile His Thr Phe Asp Pro Glu Ala Ala Cys Asp Asp 
        275                 280                 285             


Ser Thr Phe Gln Pro Cys Ser Pro Arg Ala Leu Ala Asn His Lys Glu 
    290                 295                 300                 


Val Val Asp Ser Phe Arg Ser Ile Tyr Thr Leu Asn Asp Gly Leu Ser 
305                 310                 315                 320 


Asp Ser Glu Ala Val Ala Val Gly Arg Tyr Pro Glu Asp Thr Tyr Tyr 
                325                 330                 335     


Asn Gly Asn Pro Trp Phe Leu Cys Thr Leu Ala Ala Ala Glu Gln Leu 
            340                 345                 350         


Tyr Asp Ala Leu Tyr Gln Trp Asp Lys Gln Gly Ser Leu Glu Val Thr 
        355                 360                 365             


Asp Val Ser Leu Asp Phe Phe Lys Ala Leu Tyr Ser Asp Ala Ala Thr 
    370                 375                 380                 


Gly Thr Tyr Ser Ser Ser Ser Ser Thr Tyr Ser Ser Ile Val Asp Ala 
385                 390                 395                 400 


Val Lys Thr Phe Ala Asp Gly Phe Val Ser Ile Val Glu Thr His Ala 
                405                 410                 415     


Ala Ser Asn Gly Ser Met Ser Glu Gln Tyr Asp Lys Ser Asp Gly Glu 
            420                 425                 430         


Gln Leu Ser Ala Arg Asp Leu Thr Trp Ser Tyr Ala Ala Leu Leu Thr 
        435                 440                 445             


Ala Asn Asn Arg Arg Asn Ser Val Val Pro Ala Ser Trp Gly Glu Thr 
    450                 455                 460                 


Ser Ala Ser Ser Val Pro Gly Thr Cys Ala Ala Thr Ser Ala Ile Gly 
465                 470                 475                 480 


Thr Tyr Ser Ser Val Thr Val Thr Ser Trp Pro Ser Ile Val Ala Thr 
                485                 490                 495     


Gly Gly Thr Thr Thr Thr Ala Thr Pro Thr Gly Ser Gly Ser Val Thr 
            500                 505                 510         


Ser Thr Ser Lys Thr Thr Ala Thr Ala Ser Lys Thr Ser Thr Ser Thr 
        515                 520                 525             


Ser Ser Thr Ser Cys Thr Thr Pro Thr Ala Val Ala Val Thr Phe Asp 
    530                 535                 540                 


Leu Thr Ala Thr Thr Thr Tyr Gly Glu Asn Ile Tyr Leu Val Gly Ser 
545                 550                 555                 560 


Ile Ser Gln Leu Gly Asp Trp Glu Thr Ser Asp Gly Ile Ala Leu Ser 
                565                 570                 575     


Ala Asp Lys Tyr Thr Ser Ser Asp Pro Leu Trp Tyr Val Thr Val Thr 
            580                 585                 590         


Leu Pro Ala Gly Glu Ser Phe Glu Tyr Lys Phe Ile Arg Ile Glu Ser 
        595                 600                 605             


Asp Asp Ser Val Glu Trp Glu Ser Asp Pro Asn Arg Glu Tyr Thr Val 
    610                 615                 620                 


Pro Gln Ala Cys Gly Thr Ser Thr Ala Thr Val Thr Asp Thr Trp Arg 
625                 630                 635                 640 


<210> 78
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 78
Glu Glu Gly Glu Pro Lys 
1               5       


<210> 79
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 79
Asp Val Val Tyr Pro Lys 
1               5       


<210> 80
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 80
Asp Lys Arg Glu Glu Gly Pro Lys 
1               5               


<210> 81
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 81
Lys Arg Glu Glu Gly Pro Lys 
1               5           


<210> 82
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 82
Asp Lys Arg Glu Lys Arg Glu 
1               5           


<210> 83
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 83
Asp Lys Arg 
1           


<210> 84
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid except Cys

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Any amino acid except Cys

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 84
Lys Lys Ala Ala Ala Xaa Ala Ala Ala Ala Ala Xaa Ala Ala Trp Ala 
1               5                   10                  15      


Ala Xaa Ala Ala Ala Lys Lys Lys Lys 
            20                  25  


<210> 85
<211> 130
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 85
Lys Val Phe Glu Arg Cys Glu Leu Ala Arg Thr Leu Lys Arg Leu Gly 
1               5                   10                  15      


Met Asp Gly Tyr Arg Gly Ile Ser Leu Ala Asn Trp Met Cys Leu Ala 
            20                  25                  30          


Lys Trp Glu Ser Gly Tyr Asn Thr Arg Ala Thr Asn Tyr Asn Ala Gly 
        35                  40                  45              


Asp Arg Ser Thr Asp Tyr Gly Ile Phe Gln Ile Asn Ser Arg Tyr Trp 
    50                  55                  60                  


Cys Asn Asp Gly Lys Thr Pro Gly Ala Val Asn Ala Cys Gln Leu Ser 
65                  70                  75                  80  


Cys Ser Ala Leu Leu Gln Asp Asn Ile Ala Asp Ala Val Ala Cys Ala 
                85                  90                  95      


Lys Arg Val Val Arg Asp Pro Gln Gly Ile Arg Ala Trp Val Ala Trp 
            100                 105                 110         


Arg Asn Arg Cys Gln Asn Arg Asp Val Arg Gln Tyr Val Gln Gly Cys 
        115                 120                 125             


Gly Val 
    130 


<210> 86
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 86
Ile Pro Leu Val Ala Asn Val Ser Phe Asn Ser Asp Asn Gly Ser Gln 
1               5                   10                  15      


Trp Leu Tyr Lys Arg Asp Val Val Tyr 
            20                  25  


<210> 87
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 87
Thr Leu Leu Leu Thr Leu Leu Leu Leu Leu Leu 
1               5                   10      


<210> 88
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 88
Leu Leu Leu Ile Leu Leu Leu Leu Leu Leu Val 
1               5                   10      


<210> 89
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 89
Leu Leu Ala Leu Leu Leu Ala Leu 
1               5               


<210> 90
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 90
Leu Leu Ala Leu Val Ala Ala Leu Ala Leu Ala Leu 
1               5                   10          


<210> 91
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 91
Leu Ala Ala Leu Leu Ala Leu Ala Ala Leu 
1               5                   10  


<210> 92
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 92
Leu Leu Leu Ala Leu Leu Ala Leu 
1               5               


<210> 93
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 93
Leu Leu Leu Ala Ser Leu 
1               5       


<210> 94
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 94
Leu Leu Leu Leu Ala Leu Leu Ala Leu Ala Ala Leu 
1               5                   10          


<210> 95
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 95
Ser Leu Leu Leu Leu Leu Leu Ala Leu Ala Ser Leu 
1               5                   10          


<210> 96
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 96
Ser Leu Leu Leu Leu Ala Leu Leu Ala Leu Leu Ala Ala Leu 
1               5                   10                  


<210> 97
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 97
Ala Leu Leu Leu Leu Leu Ala Leu Leu Ala Ser Leu 
1               5                   10          


<210> 98
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 98
Leu Leu Leu Leu Leu Leu Ala Leu Leu Ala Ser Leu 
1               5                   10          


<210> 99
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 99
Leu Leu Gly Leu Leu Leu Ala Leu Ala Ala Ser Leu 
1               5                   10          


<210> 100
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 100
Leu Leu Leu Ala Leu Leu Ala Leu Leu Ala Leu Ala Ser Leu 
1               5                   10                  


<210> 101
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 101
Leu Ala Leu Ala 
1               


<210> 102
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 102
Leu Ala Val Cys 
1               


<210> 103
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 103
Leu Ala Leu Ala Leu Ala 
1               5       


<210> 104
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 104
Leu Ala Val Cys His Pro 
1               5       


<210> 105
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 105
His His His His His His 
1               5       


<210> 106
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 106
Lys Leu Leu Ser Leu Leu 
1               5       

