                         SEQUENCE LISTING

<110>  Elicio Therapeutics, Inc.
 
<120>  USES OF AMPHIPHILES IN IMMUNE CELL THERAPY AND COMPOSITIONS 
       THEREFOR

<130>  51026-040WO5

<150>  US 63/306,247
<151>  2022-02-03

<150>  US 63/286,854
<151>  2021-12-07

<150>  US 63/255,829
<151>  2021-10-14

<150>  US 63/159,237
<151>  2021-03-10

<160>  1183  

<170>  PatentIn version 3.5

<210>  1
<211>  252
<212>  PRT
<213>  Influenza A virus

<400>  1

Met Ser Leu Leu Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro 
1               5                   10                  15      


Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe 
            20                  25                  30          


Ala Gly Lys Asn Thr Asp Leu Glu Val Leu Met Glu Trp Leu Lys Thr 
        35                  40                  45              


Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe 
    50                  55                  60                  


Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg Phe Val 
65                  70                  75                  80  


Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn Met Asp Lys Ala 
                85                  90                  95      


Val Lys Leu Tyr Arg Lys Leu Lys Arg Glu Ile Thr Phe His Gly Ala 
            100                 105                 110         


Lys Glu Ile Ser Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser Cys Met 
        115                 120                 125             


Gly Leu Ile Tyr Asn Arg Met Gly Ala Val Thr Thr Glu Val Ala Phe 
    130                 135                 140                 


Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln His Arg 
145                 150                 155                 160 


Ser His Arg Gln Met Val Thr Thr Thr Asn Pro Leu Ile Arg His Glu 
                165                 170                 175     


Asn Arg Met Val Leu Ala Ser Thr Thr Ala Lys Ala Met Glu Gln Met 
            180                 185                 190         


Ala Gly Ser Ser Glu Gln Ala Ala Glu Ala Met Glu Val Ala Ser Gln 
        195                 200                 205             


Ala Arg Gln Met Val Gln Ala Met Arg Thr Ile Gly Thr His Pro Ser 
    210                 215                 220                 


Ser Ser Ala Gly Leu Lys Asn Asp Leu Leu Glu Asn Leu Gln Ala Tyr 
225                 230                 235                 240 


Gln Lys Arg Met Gly Val Gln Met Gln Arg Phe Lys 
                245                 250         


<210>  2
<211>  944
<212>  PRT
<213>  Human herpesvirus 4

<400>  2

Met Asp Lys Asp Arg Pro Gly Pro Pro Ala Leu Asp Asp Asn Met Glu 
1               5                   10                  15      


Glu Glu Val Pro Ser Thr Ser Val Val Gln Glu Gln Val Ser Ala Gly 
            20                  25                  30          


Asp Trp Glu Asn Val Leu Ile Glu Leu Ser Asp Ser Ser Ser Glu Lys 
        35                  40                  45              


Glu Ala Glu Asp Ala His Leu Glu Pro Ala Gln Lys Gly Thr Lys Arg 
    50                  55                  60                  


Lys Arg Val Asp His Asp Ala Gly Gly Ser Ala Pro Ala Arg Pro Met 
65                  70                  75                  80  


Leu Pro Pro Gln Pro Asp Leu Pro Gly Arg Glu Ala Ile Leu Arg Arg 
                85                  90                  95      


Phe Pro Leu Asp Leu Arg Thr Leu Leu Gln Ala Ile Gly Ala Ala Ala 
            100                 105                 110         


Thr Arg Ile Asp Thr Arg Ala Ile Asp Gln Phe Phe Gly Ser Gln Ile 
        115                 120                 125             


Ser Asn Thr Glu Met Tyr Ile Met Tyr Ala Met Ala Ile Arg Gln Ala 
    130                 135                 140                 


Ile Arg Asp Arg Arg Arg Asn Pro Ala Ser Arg Arg Asp Gln Ala Lys 
145                 150                 155                 160 


Trp Arg Leu Gln Thr Leu Ala Ala Gly Trp Pro Met Gly Tyr Gln Ala 
                165                 170                 175     


Tyr Ser Ser Trp Met Tyr Ser Tyr Thr Asp His Gln Thr Thr Pro Thr 
            180                 185                 190         


Phe Val His Leu Gln Ala Thr Leu Gly Cys Thr Gly Gly Arg Arg Cys 
        195                 200                 205             


His Val Thr Phe Ser Ala Gly Thr Phe Lys Leu Pro Arg Cys Thr Pro 
    210                 215                 220                 


Gly Asp Arg Gln Trp Leu Tyr Val Gln Ser Ser Val Gly Asn Ile Val 
225                 230                 235                 240 


Gln Ser Cys Asn Pro Arg Tyr Ser Ile Phe Phe Asp Tyr Met Ala Ile 
                245                 250                 255     


His Arg Ser Leu Thr Lys Ile Trp Glu Glu Val Leu Thr Pro Asp Gln 
            260                 265                 270         


Arg Val Ser Phe Met Glu Phe Leu Gly Phe Leu Gln Arg Thr Asp Leu 
        275                 280                 285             


Ser Tyr Ile Lys Ser Phe Val Ser Asp Ala Leu Gly Thr Thr Ser Ile 
    290                 295                 300                 


Gln Thr Pro Trp Ile Asp Asp Asn Pro Ser Thr Glu Thr Ala Gln Ala 
305                 310                 315                 320 


Trp Asn Ala Gly Phe Leu Arg Gly Arg Ala Tyr Gly Ile Asp Leu Leu 
                325                 330                 335     


Arg Thr Glu Gly Glu His Val Glu Gly Ala Thr Gly Glu Thr Arg Glu 
            340                 345                 350         


Glu Ser Glu Asp Thr Glu Ser Asp Gly Asp Asp Glu Asp Leu Pro Cys 
        355                 360                 365             


Ile Val Ser Arg Gly Gly Pro Lys Val Lys Arg Pro Pro Ile Phe Ile 
    370                 375                 380                 


Arg Arg Leu His Arg Leu Leu Leu Met Arg Ala Gly Lys Arg Thr Glu 
385                 390                 395                 400 


Gln Gly Lys Glu Val Leu Glu Lys Ala Arg Gly Ser Thr Tyr Gly Thr 
                405                 410                 415     


Pro Arg Pro Pro Val Pro Lys Pro Arg Pro Glu Val Pro Gln Ser Asp 
            420                 425                 430         


Glu Thr Ala Thr Ser His Gly Ser Ala Gln Val Pro Glu Pro Pro Thr 
        435                 440                 445             


Ile His Leu Ala Ala Gln Gly Met Ala Tyr Pro Leu His Glu Gln His 
    450                 455                 460                 


Gly Met Ala Pro Cys Pro Val Ala Gln Ala Pro Pro Thr Pro Leu Pro 
465                 470                 475                 480 


Pro Val Ser Pro Gly Asp Gln Leu Pro Gly Val Phe Ser Asp Gly Arg 
                485                 490                 495     


Val Ala Cys Ala Pro Val Pro Ala Pro Ala Gly Pro Ile Val Arg Pro 
            500                 505                 510         


Trp Glu Pro Ser Leu Thr Gln Ala Ala Gly Gln Ala Phe Ala Pro Val 
        515                 520                 525             


Arg Pro Gln His Met Pro Val Glu Pro Val Pro Val Pro Thr Val Ala 
    530                 535                 540                 


Leu Glu Arg Pro Val Tyr Pro Lys Pro Val Arg Pro Ala Pro Pro Lys 
545                 550                 555                 560 


Ile Ala Met Gln Gly Pro Gly Glu Thr Ser Gly Ile Arg Arg Ala Arg 
                565                 570                 575     


Glu Arg Trp Arg Pro Ala Pro Trp Thr Pro Asn Pro Pro Arg Ser Pro 
            580                 585                 590         


Ser Gln Met Ser Val Arg Asp Arg Leu Ala Arg Leu Arg Ala Glu Ala 
        595                 600                 605             


Gln Val Lys Gln Ala Ser Val Glu Val Gln Pro Pro Gln Leu Thr Gln 
    610                 615                 620                 


Val Ser Pro Gln Gln Pro Met Glu Gly Pro Leu Val Pro Glu Gln Gln 
625                 630                 635                 640 


Met Phe Pro Gly Ala Pro Phe Ser Gln Val Ala Asp Val Val Arg Ala 
                645                 650                 655     


Pro Gly Val Pro Ala Met Gln Pro Gln Tyr Phe Asp Leu Pro Leu Ile 
            660                 665                 670         


Gln Pro Ile Ser Gln Gly Ala Pro Val Ala Pro Leu Arg Ala Ser Met 
        675                 680                 685             


Gly Pro Val Pro Pro Val Pro Ala Thr Gln Pro Gln Tyr Phe Asp Ile 
    690                 695                 700                 


Pro Leu Thr Glu Pro Ile Asn Gln Gly Ala Ser Ala Ala His Phe Leu 
705                 710                 715                 720 


Pro Gln Gln Pro Met Glu Gly Pro Leu Val Pro Glu Gln Trp Met Phe 
                725                 730                 735     


Pro Gly Ala Ala Leu Ser Gln Ser Val Arg Pro Gly Val Ala Gln Ser 
            740                 745                 750         


Gln Tyr Phe Asp Leu Pro Leu Thr Gln Pro Ile Asn His Gly Ala Pro 
        755                 760                 765             


Ala Ala His Phe Leu His Gln Pro Pro Met Glu Gly Pro Trp Val Pro 
    770                 775                 780                 


Glu Gln Trp Met Phe Gln Gly Ala Pro Pro Ser Gln Gly Thr Asp Val 
785                 790                 795                 800 


Val Gln His Gln Leu Asp Ala Leu Gly Tyr Thr Leu His Gly Leu Asn 
                805                 810                 815     


His Pro Gly Val Pro Val Ser Pro Ala Val Asn Gln Tyr His Leu Ser 
            820                 825                 830         


Gln Ala Ala Phe Gly Leu Pro Ile Asp Glu Asp Glu Ser Gly Glu Gly 
        835                 840                 845             


Ser Asp Thr Ser Glu Pro Cys Glu Ala Leu Asp Leu Ser Ile His Gly 
    850                 855                 860                 


Arg Pro Cys Pro Gln Ala Pro Glu Trp Pro Val Gln Glu Glu Gly Gly 
865                 870                 875                 880 


Gln Asp Ala Thr Glu Val Leu Asp Leu Ser Ile His Gly Arg Pro Arg 
                885                 890                 895     


Pro Arg Thr Pro Glu Trp Pro Val Gln Gly Glu Gly Gly Gln Asn Val 
            900                 905                 910         


Thr Gly Pro Glu Thr Arg Arg Val Val Val Ser Ala Val Val His Met 
        915                 920                 925             


Cys Gln Asp Asp Glu Phe Pro Asp Leu Gln Asp Pro Pro Asp Glu Ala 
    930                 935                 940                 


<210>  3
<211>  257
<212>  PRT
<213>  Human respiratory syncytial virus B1

<400>  3

Met Glu Thr Tyr Val Asn Lys Leu His Glu Gly Ser Thr Tyr Thr Ala 
1               5                   10                  15      


Ala Val Gln Tyr Asn Val Leu Glu Lys Asp Asp Asp Pro Ala Ser Leu 
            20                  25                  30          


Thr Ile Trp Val Pro Met Phe Gln Ser Ser Val Pro Ala Asp Leu Ser 
        35                  40                  45              


Leu Ile Lys Glu Leu Ala Ser Ile Asn Ile Leu Val Lys Gln Ile Ser 
    50                  55                  60                  


Thr Pro Lys Gly Pro Ser Leu Arg Val Thr Ile Asn Ser Arg Ser Ala 
65                  70                  75                  80  


Val Leu Ala Gln Met Pro Ser Asn Phe Ile Ile Ser Ala Asn Val Ser 
                85                  90                  95      


Leu Asp Glu Arg Ser Lys Leu Ala Tyr Asp Val Thr Thr Pro Cys Glu 
            100                 105                 110         


Ile Lys Ala Cys Ser Leu Thr Cys Leu Lys Val Lys Ser Met Leu Thr 
        115                 120                 125             


Thr Val Lys Asp Leu Thr Met Lys Thr Phe Asn Pro Thr His Glu Ile 
    130                 135                 140                 


Ile Ala Leu Cys Glu Phe Glu Asn Ile Met Thr Ser Lys Arg Val Ile 
145                 150                 155                 160 


Ile Pro Thr Tyr Leu Arg Pro Ile Ser Val Lys Asn Lys Asp Leu Asn 
                165                 170                 175     


Ser Leu Glu Asn Ile Ala Thr Thr Glu Phe Lys Asn Ala Ile Thr Asn 
            180                 185                 190         


Ala Lys Ile Ile Pro Tyr Ala Gly Leu Val Leu Val Ile Thr Val Thr 
        195                 200                 205             


Asp Asn Lys Gly Ala Phe Lys Tyr Ile Lys Pro Gln Ser Gln Phe Ile 
    210                 215                 220                 


Val Asp Leu Gly Ala Tyr Leu Glu Lys Glu Ser Ile Tyr Tyr Val Thr 
225                 230                 235                 240 


Thr Asn Trp Lys His Thr Ala Thr Arg Phe Ser Ile Lys Pro Leu Glu 
                245                 250                 255     


Asp 
    


<210>  4
<211>  2261
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Cys Trp Pro Gln Leu Arg Leu Leu Leu Trp Lys Asn Leu Thr 
1               5                   10                  15      


Phe Arg Arg Arg Gln Thr Cys Gln Leu Leu Leu Glu Val Ala Trp Pro 
            20                  25                  30          


Leu Phe Ile Phe Leu Ile Leu Ile Ser Val Arg Leu Ser Tyr Pro Pro 
        35                  40                  45              


Tyr Glu Gln His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  


Gly Thr Leu Pro Trp Val Gln Gly Ile Ile Cys Asn Ala Asn Asn Pro 
65                  70                  75                  80  


Cys Phe Arg Tyr Pro Thr Pro Gly Glu Ala Pro Gly Val Val Gly Asn 
                85                  90                  95      


Phe Asn Lys Ser Ile Val Ala Arg Leu Phe Ser Asp Ala Arg Arg Leu 
            100                 105                 110         


Leu Leu Tyr Ser Gln Lys Asp Thr Ser Met Lys Asp Met Arg Lys Val 
        115                 120                 125             


Leu Arg Thr Leu Gln Gln Ile Lys Lys Ser Ser Ser Asn Leu Lys Leu 
    130                 135                 140                 


Gln Asp Phe Leu Val Asp Asn Glu Thr Phe Ser Gly Phe Leu Tyr His 
145                 150                 155                 160 


Asn Leu Ser Leu Pro Lys Ser Thr Val Asp Lys Met Leu Arg Ala Asp 
                165                 170                 175     


Val Ile Leu His Lys Val Phe Leu Gln Gly Tyr Gln Leu His Leu Thr 
            180                 185                 190         


Ser Leu Cys Asn Gly Ser Lys Ser Glu Glu Met Ile Gln Leu Gly Asp 
        195                 200                 205             


Gln Glu Val Ser Glu Leu Cys Gly Leu Pro Arg Glu Lys Leu Ala Ala 
    210                 215                 220                 


Ala Glu Arg Val Leu Arg Ser Asn Met Asp Ile Leu Lys Pro Ile Leu 
225                 230                 235                 240 


Arg Thr Leu Asn Ser Thr Ser Pro Phe Pro Ser Lys Glu Leu Ala Glu 
                245                 250                 255     


Ala Thr Lys Thr Leu Leu His Ser Leu Gly Thr Leu Ala Gln Glu Leu 
            260                 265                 270         


Phe Ser Met Arg Ser Trp Ser Asp Met Arg Gln Glu Val Met Phe Leu 
        275                 280                 285             


Thr Asn Val Asn Ser Ser Ser Ser Ser Thr Gln Ile Tyr Gln Ala Val 
    290                 295                 300                 


Ser Arg Ile Val Cys Gly His Pro Glu Gly Gly Gly Leu Lys Ile Lys 
305                 310                 315                 320 


Ser Leu Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Leu Phe Gly Gly 
                325                 330                 335     


Asn Gly Thr Glu Glu Asp Ala Glu Thr Phe Tyr Asp Asn Ser Thr Thr 
            340                 345                 350         


Pro Tyr Cys Asn Asp Leu Met Lys Asn Leu Glu Ser Ser Pro Leu Ser 
        355                 360                 365             


Arg Ile Ile Trp Lys Ala Leu Lys Pro Leu Leu Val Gly Lys Ile Leu 
    370                 375                 380                 


Tyr Thr Pro Asp Thr Pro Ala Thr Arg Gln Val Met Ala Glu Val Asn 
385                 390                 395                 400 


Lys Thr Phe Gln Glu Leu Ala Val Phe His Asp Leu Glu Gly Met Trp 
                405                 410                 415     


Glu Glu Leu Ser Pro Lys Ile Trp Thr Phe Met Glu Asn Ser Gln Glu 
            420                 425                 430         


Met Asp Leu Val Arg Met Leu Leu Asp Ser Arg Asp Asn Asp His Phe 
        435                 440                 445             


Trp Glu Gln Gln Leu Asp Gly Leu Asp Trp Thr Ala Gln Asp Ile Val 
    450                 455                 460                 


Ala Phe Leu Ala Lys His Pro Glu Asp Val Gln Ser Ser Asn Gly Ser 
465                 470                 475                 480 


Val Tyr Thr Trp Arg Glu Ala Phe Asn Glu Thr Asn Gln Ala Ile Arg 
                485                 490                 495     


Thr Ile Ser Arg Phe Met Glu Cys Val Asn Leu Asn Lys Leu Glu Pro 
            500                 505                 510         


Ile Ala Thr Glu Val Trp Leu Ile Asn Lys Ser Met Glu Leu Leu Asp 
        515                 520                 525             


Glu Arg Lys Phe Trp Ala Gly Ile Val Phe Thr Gly Ile Thr Pro Gly 
    530                 535                 540                 


Ser Ile Glu Leu Pro His His Val Lys Tyr Lys Ile Arg Met Asp Ile 
545                 550                 555                 560 


Asp Asn Val Glu Arg Thr Asn Lys Ile Lys Asp Gly Tyr Trp Asp Pro 
                565                 570                 575     


Gly Pro Arg Ala Asp Pro Phe Glu Asp Met Arg Tyr Val Trp Gly Gly 
            580                 585                 590         


Phe Ala Tyr Leu Gln Asp Val Val Glu Gln Ala Ile Ile Arg Val Leu 
        595                 600                 605             


Thr Gly Thr Glu Lys Lys Thr Gly Val Tyr Met Gln Gln Met Pro Tyr 
    610                 615                 620                 


Pro Cys Tyr Val Asp Asp Ile Phe Leu Arg Val Met Ser Arg Ser Met 
625                 630                 635                 640 


Pro Leu Phe Met Thr Leu Ala Trp Ile Tyr Ser Val Ala Val Ile Ile 
                645                 650                 655     


Lys Gly Ile Val Tyr Glu Lys Glu Ala Arg Leu Lys Glu Thr Met Arg 
            660                 665                 670         


Ile Met Gly Leu Asp Asn Ser Ile Leu Trp Phe Ser Trp Phe Ile Ser 
        675                 680                 685             


Ser Leu Ile Pro Leu Leu Val Ser Ala Gly Leu Leu Val Val Ile Leu 
    690                 695                 700                 


Lys Leu Gly Asn Leu Leu Pro Tyr Ser Asp Pro Ser Val Val Phe Val 
705                 710                 715                 720 


Phe Leu Ser Val Phe Ala Val Val Thr Ile Leu Gln Cys Phe Leu Ile 
                725                 730                 735     


Ser Thr Leu Phe Ser Arg Ala Asn Leu Ala Ala Ala Cys Gly Gly Ile 
            740                 745                 750         


Ile Tyr Phe Thr Leu Tyr Leu Pro Tyr Val Leu Cys Val Ala Trp Gln 
        755                 760                 765             


Asp Tyr Val Gly Phe Thr Leu Lys Ile Phe Ala Ser Leu Leu Ser Pro 
    770                 775                 780                 


Val Ala Phe Gly Phe Gly Cys Glu Tyr Phe Ala Leu Phe Glu Glu Gln 
785                 790                 795                 800 


Gly Ile Gly Val Gln Trp Asp Asn Leu Phe Glu Ser Pro Val Glu Glu 
                805                 810                 815     


Asp Gly Phe Asn Leu Thr Thr Ser Val Ser Met Met Leu Phe Asp Thr 
            820                 825                 830         


Phe Leu Tyr Gly Val Met Thr Trp Tyr Ile Glu Ala Val Phe Pro Gly 
        835                 840                 845             


Gln Tyr Gly Ile Pro Arg Pro Trp Tyr Phe Pro Cys Thr Lys Ser Tyr 
    850                 855                 860                 


Trp Phe Gly Glu Glu Ser Asp Glu Lys Ser His Pro Gly Ser Asn Gln 
865                 870                 875                 880 


Lys Arg Ile Ser Glu Ile Cys Met Glu Glu Glu Pro Thr His Leu Lys 
                885                 890                 895     


Leu Gly Val Ser Ile Gln Asn Leu Val Lys Val Tyr Arg Asp Gly Met 
            900                 905                 910         


Lys Val Ala Val Asp Gly Leu Ala Leu Asn Phe Tyr Glu Gly Gln Ile 
        915                 920                 925             


Thr Ser Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Met Ser 
    930                 935                 940                 


Ile Leu Thr Gly Leu Phe Pro Pro Thr Ser Gly Thr Ala Tyr Ile Leu 
945                 950                 955                 960 


Gly Lys Asp Ile Arg Ser Glu Met Ser Thr Ile Arg Gln Asn Leu Gly 
                965                 970                 975     


Val Cys Pro Gln His Asn Val Leu Phe Asp Met Leu Thr Val Glu Glu 
            980                 985                 990         


His Ile Trp Phe Tyr Ala Arg Leu  Lys Gly Leu Ser Glu  Lys His Val 
        995                 1000                 1005             


Lys Ala  Glu Met Glu Gln Met  Ala Leu Asp Val Gly  Leu Pro Ser 
    1010                 1015                 1020             


Ser Lys  Leu Lys Ser Lys Thr  Ser Gln Leu Ser Gly  Gly Met Gln 
    1025                 1030                 1035             


Arg Lys  Leu Ser Val Ala Leu  Ala Phe Val Gly Gly  Ser Lys Val 
    1040                 1045                 1050             


Val Ile  Leu Asp Glu Pro Thr  Ala Gly Val Asp Pro  Tyr Ser Arg 
    1055                 1060                 1065             


Arg Gly  Ile Trp Glu Leu Leu  Leu Lys Tyr Arg Gln  Gly Arg Thr 
    1070                 1075                 1080             


Ile Ile  Leu Ser Thr His His  Met Asp Glu Ala Asp  Val Leu Gly 
    1085                 1090                 1095             


Asp Arg  Ile Ala Ile Ile Ser  His Gly Lys Leu Cys  Cys Val Gly 
    1100                 1105                 1110             


Ser Ser  Leu Phe Leu Lys Asn  Gln Leu Gly Thr Gly  Tyr Tyr Leu 
    1115                 1120                 1125             


Thr Leu  Val Lys Lys Asp Val  Glu Ser Ser Leu Ser  Ser Cys Arg 
    1130                 1135                 1140             


Asn Ser  Ser Ser Thr Val Ser  Tyr Leu Lys Lys Glu  Asp Ser Val 
    1145                 1150                 1155             


Ser Gln  Ser Ser Ser Asp Ala  Gly Leu Gly Ser Asp  His Glu Ser 
    1160                 1165                 1170             


Asp Thr  Leu Thr Ile Asp Val  Ser Ala Ile Ser Asn  Leu Ile Arg 
    1175                 1180                 1185             


Lys His  Val Ser Glu Ala Arg  Leu Val Glu Asp Ile  Gly His Glu 
    1190                 1195                 1200             


Leu Thr  Tyr Val Leu Pro Tyr  Glu Ala Ala Lys Glu  Gly Ala Phe 
    1205                 1210                 1215             


Val Glu  Leu Phe His Glu Ile  Asp Asp Arg Leu Ser  Asp Leu Gly 
    1220                 1225                 1230             


Ile Ser  Ser Tyr Gly Ile Ser  Glu Thr Thr Leu Glu  Glu Ile Phe 
    1235                 1240                 1245             


Leu Lys  Val Ala Glu Glu Ser  Gly Val Asp Ala Glu  Thr Ser Asp 
    1250                 1255                 1260             


Gly Thr  Leu Pro Ala Arg Arg  Asn Arg Arg Ala Phe  Gly Asp Lys 
    1265                 1270                 1275             


Gln Ser  Cys Leu Arg Pro Phe  Thr Glu Asp Asp Ala  Ala Asp Pro 
    1280                 1285                 1290             


Asn Asp  Ser Asp Ile Asp Pro  Glu Ser Arg Glu Thr  Asp Leu Leu 
    1295                 1300                 1305             


Ser Gly  Met Asp Gly Lys Gly  Ser Tyr Gln Val Lys  Gly Trp Lys 
    1310                 1315                 1320             


Leu Thr  Gln Gln Gln Phe Val  Ala Leu Leu Trp Lys  Arg Leu Leu 
    1325                 1330                 1335             


Ile Ala  Arg Arg Ser Arg Lys  Gly Phe Phe Ala Gln  Ile Val Leu 
    1340                 1345                 1350             


Pro Ala  Val Phe Val Cys Ile  Ala Leu Val Phe Ser  Leu Ile Val 
    1355                 1360                 1365             


Pro Pro  Phe Gly Lys Tyr Pro  Ser Leu Glu Leu Gln  Pro Trp Met 
    1370                 1375                 1380             


Tyr Asn  Glu Gln Tyr Thr Phe  Val Ser Asn Asp Ala  Pro Glu Asp 
    1385                 1390                 1395             


Thr Gly  Thr Leu Glu Leu Leu  Asn Ala Leu Thr Lys  Asp Pro Gly 
    1400                 1405                 1410             


Phe Gly  Thr Arg Cys Met Glu  Gly Asn Pro Ile Pro  Asp Thr Pro 
    1415                 1420                 1425             


Cys Gln  Ala Gly Glu Glu Glu  Trp Thr Thr Ala Pro  Val Pro Gln 
    1430                 1435                 1440             


Thr Ile  Met Asp Leu Phe Gln  Asn Gly Asn Trp Thr  Met Gln Asn 
    1445                 1450                 1455             


Pro Ser  Pro Ala Cys Gln Cys  Ser Ser Asp Lys Ile  Lys Lys Met 
    1460                 1465                 1470             


Leu Pro  Val Cys Pro Pro Gly  Ala Gly Gly Leu Pro  Pro Pro Gln 
    1475                 1480                 1485             


Arg Lys  Gln Asn Thr Ala Asp  Ile Leu Gln Asp Leu  Thr Gly Arg 
    1490                 1495                 1500             


Asn Ile  Ser Asp Tyr Leu Val  Lys Thr Tyr Val Gln  Ile Ile Ala 
    1505                 1510                 1515             


Lys Ser  Leu Lys Asn Lys Ile  Trp Val Asn Glu Phe  Arg Tyr Gly 
    1520                 1525                 1530             


Gly Phe  Ser Leu Gly Val Ser  Asn Thr Gln Ala Leu  Pro Pro Ser 
    1535                 1540                 1545             


Gln Glu  Val Asn Asp Ala Ile  Lys Gln Met Lys Lys  His Leu Lys 
    1550                 1555                 1560             


Leu Ala  Lys Asp Ser Ser Ala  Asp Arg Phe Leu Asn  Ser Leu Gly 
    1565                 1570                 1575             


Arg Phe  Met Thr Gly Leu Asp  Thr Lys Asn Asn Val  Lys Val Trp 
    1580                 1585                 1590             


Phe Asn  Asn Lys Gly Trp His  Ala Ile Ser Ser Phe  Leu Asn Val 
    1595                 1600                 1605             


Ile Asn  Asn Ala Ile Leu Arg  Ala Asn Leu Gln Lys  Gly Glu Asn 
    1610                 1615                 1620             


Pro Ser  His Tyr Gly Ile Thr  Ala Phe Asn His Pro  Leu Asn Leu 
    1625                 1630                 1635             


Thr Lys  Gln Gln Leu Ser Glu  Val Ala Leu Met Thr  Thr Ser Val 
    1640                 1645                 1650             


Asp Val  Leu Val Ser Ile Cys  Val Ile Phe Ala Met  Ser Phe Val 
    1655                 1660                 1665             


Pro Ala  Ser Phe Val Val Phe  Leu Ile Gln Glu Arg  Val Ser Lys 
    1670                 1675                 1680             


Ala Lys  His Leu Gln Phe Ile  Ser Gly Val Lys Pro  Val Ile Tyr 
    1685                 1690                 1695             


Trp Leu  Ser Asn Phe Val Trp  Asp Met Cys Asn Tyr  Val Val Pro 
    1700                 1705                 1710             


Ala Thr  Leu Val Ile Ile Ile  Phe Ile Cys Phe Gln  Gln Lys Ser 
    1715                 1720                 1725             


Tyr Val  Ser Ser Thr Asn Leu  Pro Val Leu Ala Leu  Leu Leu Leu 
    1730                 1735                 1740             


Leu Tyr  Gly Trp Ser Ile Thr  Pro Leu Met Tyr Pro  Ala Ser Phe 
    1745                 1750                 1755             


Val Phe  Lys Ile Pro Ser Thr  Ala Tyr Val Val Leu  Thr Ser Val 
    1760                 1765                 1770             


Asn Leu  Phe Ile Gly Ile Asn  Gly Ser Val Ala Thr  Phe Val Leu 
    1775                 1780                 1785             


Glu Leu  Phe Thr Asp Asn Lys  Leu Asn Asn Ile Asn  Asp Ile Leu 
    1790                 1795                 1800             


Lys Ser  Val Phe Leu Ile Phe  Pro His Phe Cys Leu  Gly Arg Gly 
    1805                 1810                 1815             


Leu Ile  Asp Met Val Lys Asn  Gln Ala Met Ala Asp  Ala Leu Glu 
    1820                 1825                 1830             


Arg Phe  Gly Glu Asn Arg Phe  Val Ser Pro Leu Ser  Trp Asp Leu 
    1835                 1840                 1845             


Val Gly  Arg Asn Leu Phe Ala  Met Ala Val Glu Gly  Val Val Phe 
    1850                 1855                 1860             


Phe Leu  Ile Thr Val Leu Ile  Gln Tyr Arg Phe Phe  Ile Arg Pro 
    1865                 1870                 1875             


Arg Pro  Val Asn Ala Lys Leu  Ser Pro Leu Asn Asp  Glu Asp Glu 
    1880                 1885                 1890             


Asp Val  Arg Arg Glu Arg Gln  Arg Ile Leu Asp Gly  Gly Gly Gln 
    1895                 1900                 1905             


Asn Asp  Ile Leu Glu Ile Lys  Glu Leu Thr Lys Ile  Tyr Arg Arg 
    1910                 1915                 1920             


Lys Arg  Lys Pro Ala Val Asp  Arg Ile Cys Val Gly  Ile Pro Pro 
    1925                 1930                 1935             


Gly Glu  Cys Phe Gly Leu Leu  Gly Val Asn Gly Ala  Gly Lys Ser 
    1940                 1945                 1950             


Ser Thr  Phe Lys Met Leu Thr  Gly Asp Thr Thr Val  Thr Arg Gly 
    1955                 1960                 1965             


Asp Ala  Phe Leu Asn Lys Asn  Ser Ile Leu Ser Asn  Ile His Glu 
    1970                 1975                 1980             


Val His  Gln Asn Met Gly Tyr  Cys Pro Gln Phe Asp  Ala Ile Thr 
    1985                 1990                 1995             


Glu Leu  Leu Thr Gly Arg Glu  His Val Glu Phe Phe  Ala Leu Leu 
    2000                 2005                 2010             


Arg Gly  Val Pro Glu Lys Glu  Val Gly Lys Val Gly  Glu Trp Ala 
    2015                 2020                 2025             


Ile Arg  Lys Leu Gly Leu Val  Lys Tyr Gly Glu Lys  Tyr Ala Gly 
    2030                 2035                 2040             


Asn Tyr  Ser Gly Gly Asn Lys  Arg Lys Leu Ser Thr  Ala Met Ala 
    2045                 2050                 2055             


Leu Ile  Gly Gly Pro Pro Val  Val Phe Leu Asp Glu  Pro Thr Thr 
    2060                 2065                 2070             


Gly Met  Asp Pro Lys Ala Arg  Arg Phe Leu Trp Asn  Cys Ala Leu 
    2075                 2080                 2085             


Ser Val  Val Lys Glu Gly Arg  Ser Val Val Leu Thr  Ser His Ser 
    2090                 2095                 2100             


Met Glu  Glu Cys Glu Ala Leu  Cys Thr Arg Met Ala  Ile Met Val 
    2105                 2110                 2115             


Asn Gly  Arg Phe Arg Cys Leu  Gly Ser Val Gln His  Leu Lys Asn 
    2120                 2125                 2130             


Arg Phe  Gly Asp Gly Tyr Thr  Ile Val Val Arg Ile  Ala Gly Ser 
    2135                 2140                 2145             


Asn Pro  Asp Leu Lys Pro Val  Gln Asp Phe Phe Gly  Leu Ala Phe 
    2150                 2155                 2160             


Pro Gly  Ser Val Leu Lys Glu  Lys His Arg Asn Met  Leu Gln Tyr 
    2165                 2170                 2175             


Gln Leu  Pro Ser Ser Leu Ser  Ser Leu Ala Arg Ile  Phe Ser Ile 
    2180                 2185                 2190             


Leu Ser  Gln Ser Lys Lys Arg  Leu His Ile Glu Asp  Tyr Ser Val 
    2195                 2200                 2205             


Ser Gln  Thr Thr Leu Asp Gln  Val Phe Val Asn Phe  Ala Lys Asp 
    2210                 2215                 2220             


Gln Ser  Asp Asp Asp His Leu  Lys Asp Leu Ser Leu  His Lys Asn 
    2225                 2230                 2235             


Gln Thr  Val Val Asp Val Ala  Val Leu Thr Ser Phe  Leu Gln Asp 
    2240                 2245                 2250             


Glu Lys  Val Lys Glu Ser Tyr  Val 
    2255                 2260     


<210>  5
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Pro Ile Pro Ala Ser Pro Leu His Pro Pro Leu Pro Ser Leu Leu 
1               5                   10                  15      


Leu Tyr Leu Leu Leu Glu Leu Ala Gly Val Thr His Val Phe His Val 
            20                  25                  30          


Gln Gln Thr Glu Met Ser Gln Thr Val Ser Thr Gly Glu Ser Ile Ile 
        35                  40                  45              


Leu Ser Cys Ser Val Pro Asn Thr Leu Pro Asn Gly Pro Val Leu Trp 
    50                  55                  60                  


Phe Lys Gly Thr Gly Pro Asn Arg Lys Leu Ile Tyr Asn Phe Lys Gln 
65                  70                  75                  80  


Gly Asn Phe Pro Arg Val Lys Glu Ile Gly Asp Thr Thr Lys Pro Gly 
                85                  90                  95      


Asn Thr Asp Phe Ser Thr Arg Ile Arg Glu Ile Ser Leu Ala Asp Ala 
            100                 105                 110         


Gly Thr Tyr Tyr Cys Val Lys Phe Ile Lys Gly Arg Ala Ile Lys Glu 
        115                 120                 125             


Tyr Gln Ser Gly Arg Gly Thr Gln Val Phe Val Thr Glu Gln Asn Pro 
    130                 135                 140                 


Arg Pro Pro Lys Asn Arg Pro Ala Gly Arg Ala Gly Ser Arg Ala His 
145                 150                 155                 160 


His Asp Ala His Thr Cys Leu Ser Ala Leu Pro Glu Arg Asn Ser Thr 
                165                 170                 175     


Asn Tyr Phe Val Gln Pro Cys Cys Cys Leu Arg Leu Leu Gly Leu Thr 
            180                 185                 190         


Gly Leu Leu Ser Lys 
        195         


<210>  6
<211>  642
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Pro Cys Gly Glu Asp Trp Leu Ser His Pro Leu Gly Ile Val Gln 
1               5                   10                  15      


Gly Phe Phe Ala Gln Asn Gly Val Asn Pro Asp Trp Glu Lys Lys Val 
            20                  25                  30          


Ile Glu Tyr Phe Lys Glu Lys Leu Lys Glu Asn Asn Ala Pro Lys Trp 
        35                  40                  45              


Val Pro Ser Leu Asn Glu Val Pro Leu His Tyr Leu Lys Pro Asn Ser 
    50                  55                  60                  


Phe Val Lys Phe Arg Cys Met Ile Gln Asp Met Phe Asp Pro Glu Phe 
65                  70                  75                  80  


Tyr Met Gly Val Tyr Glu Thr Val Asn Gln Asn Thr Lys Ala His Val 
                85                  90                  95      


Leu His Phe Gly Lys Tyr Arg Asp Val Ala Glu Cys Gly Pro Gln Gln 
            100                 105                 110         


Glu Leu Asp Leu Asn Ser Pro Arg Asn Thr Thr Leu Glu Arg Gln Thr 
        115                 120                 125             


Phe Tyr Cys Val Pro Val Pro Gly Glu Ser Thr Trp Val Lys Glu Ala 
    130                 135                 140                 


Tyr Val Asn Ala Asn Gln Ala Arg Val Ser Pro Ser Thr Ser Tyr Thr 
145                 150                 155                 160 


Pro Ser Arg His Lys Arg Ser Tyr Glu Asp Asp Asp Asp Met Asp Leu 
                165                 170                 175     


Gln Pro Asn Lys Gln Lys Asp Gln His Ala Gly Ala Arg Gln Ala Gly 
            180                 185                 190         


Ser Val Gly Gly Leu Gln Trp Cys Gly Glu Pro Lys Arg Leu Glu Thr 
        195                 200                 205             


Glu Ala Ser Thr Gly Gln Gln Leu Asn Ser Leu Asn Leu Ser Ser Pro 
    210                 215                 220                 


Phe Asp Leu Asn Phe Pro Leu Pro Gly Glu Lys Gly Pro Ala Cys Leu 
225                 230                 235                 240 


Val Lys Val Tyr Glu Asp Trp Asp Cys Phe Lys Val Asn Asp Ile Leu 
                245                 250                 255     


Glu Leu Tyr Gly Ile Leu Ser Val Asp Pro Val Leu Ser Ile Leu Asn 
            260                 265                 270         


Asn Asp Glu Arg Asp Ala Ser Ala Leu Leu Asp Pro Met Glu Cys Thr 
        275                 280                 285             


Asp Thr Ala Glu Glu Gln Arg Val His Ser Pro Pro Ala Ser Leu Val 
    290                 295                 300                 


Pro Arg Ile His Val Ile Leu Ala Gln Lys Leu Gln His Ile Asn Pro 
305                 310                 315                 320 


Leu Leu Pro Ala Cys Leu Asn Lys Glu Glu Ser Lys Thr Cys Lys Phe 
                325                 330                 335     


Val Ser Ser Phe Met Ser Glu Leu Ser Pro Val Arg Ala Glu Leu Leu 
            340                 345                 350         


Gly Phe Leu Thr His Ala Leu Leu Gly Asp Ser Leu Ala Ala Glu Tyr 
        355                 360                 365             


Leu Ile Leu His Leu Ile Ser Thr Val Tyr Thr Arg Arg Asp Val Leu 
    370                 375                 380                 


Pro Leu Gly Lys Phe Thr Val Asn Leu Ser Gly Cys Pro Arg Asn Ser 
385                 390                 395                 400 


Thr Phe Thr Glu His Leu Tyr Arg Ile Ile Gln His Leu Val Pro Ala 
                405                 410                 415     


Ser Phe Arg Leu Gln Met Thr Ile Glu Asn Met Asn His Leu Lys Phe 
            420                 425                 430         


Ile Pro His Lys Asp Tyr Thr Ala Asn Arg Leu Val Ser Gly Leu Leu 
        435                 440                 445             


Gln Leu Pro Ser Asn Thr Ser Leu Val Ile Asp Glu Thr Leu Leu Glu 
    450                 455                 460                 


Gln Gly Gln Leu Asp Thr Pro Gly Val His Asn Val Thr Ala Leu Ser 
465                 470                 475                 480 


Asn Leu Ile Thr Trp Gln Lys Val Asp Tyr Asp Phe Ser Tyr His Gln 
                485                 490                 495     


Met Glu Phe Pro Cys Asn Ile Asn Val Phe Ile Thr Ser Glu Gly Arg 
            500                 505                 510         


Ser Leu Leu Pro Ala Asp Cys Gln Ile His Leu Gln Pro Gln Leu Ile 
        515                 520                 525             


Pro Pro Asn Met Glu Glu Tyr Met Asn Ser Leu Leu Ser Ala Val Leu 
    530                 535                 540                 


Pro Ser Val Leu Asn Lys Phe Arg Ile Tyr Leu Thr Leu Leu Arg Phe 
545                 550                 555                 560 


Leu Glu Tyr Ser Ile Ser Asp Glu Ile Thr Lys Ala Val Glu Asp Asp 
                565                 570                 575     


Phe Val Glu Met Arg Lys Asn Asp Pro Gln Ser Ile Thr Ala Asp Asp 
            580                 585                 590         


Leu His Gln Leu Leu Val Val Ala Arg Cys Leu Ser Leu Ser Ala Gly 
        595                 600                 605             


Gln Thr Thr Leu Ser Arg Glu Arg Trp Leu Arg Ala Lys Gln Leu Glu 
    610                 615                 620                 


Ser Leu Arg Arg Thr Arg Leu Gln Gln Gln Lys Cys Val Asn Gly Asn 
625                 630                 635                 640 


Glu Leu 
        


<210>  7
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ser Ser His Arg Arg Lys Ala Lys Gly Arg Asn Arg Arg Ser His 
1               5                   10                  15      


Arg Ala Met Arg Val Ala His Leu Glu Leu Ala Thr Tyr Glu Leu Ala 
            20                  25                  30          


Ala Thr Glu Ser Asn Pro Glu Ser Ser His Pro Gly Tyr Glu Ala Ala 
        35                  40                  45              


Met Ala Asp Arg Pro Gln Pro Gly Trp Arg Glu Ser Leu Lys Met Arg 
    50                  55                  60                  


Val Ser Lys Pro Phe Gly Met Leu Met Leu Ser Ile Trp Ile Leu Leu 
65                  70                  75                  80  


Phe Val Cys Tyr Tyr Leu Ser Tyr Tyr Leu Cys Ser Gly Ser Ser Tyr 
                85                  90                  95      


Phe Val Leu Ala Asn Gly His Ile Leu Pro Asn Ser Glu Asn Ala His 
            100                 105                 110         


Gly Gln Ser Leu Glu Glu Asp Ser Ala Leu Glu Ala Leu Leu Asn Phe 
        115                 120                 125             


Phe Phe Pro Thr Thr Cys Asn Leu Arg Glu Asn Gln Val Ala Lys Pro 
    130                 135                 140                 


Cys Asn Glu Leu Gln Asp Leu Ser Glu Ser Glu Cys Leu Arg His Lys 
145                 150                 155                 160 


Cys Cys Phe Ser Ser Ser Gly Thr Thr Ser Phe Lys Cys Phe Ala Pro 
                165                 170                 175     


Phe Arg Asp Val Pro Lys Gln Met Met Gln Met Phe Gly Leu Gly Ala 
            180                 185                 190         


Ile Ser Leu Ile Leu Val Cys Leu Pro Ile Tyr Cys Arg Ser Leu Phe 
        195                 200                 205             


Trp Arg Ser Glu Pro Ala Asp Asp Leu Gln Arg Gln Asp Asn Arg Val 
    210                 215                 220                 


Val Thr Gly Leu Lys Lys Gln Arg Arg Lys Arg Lys Arg Lys Ser Glu 
225                 230                 235                 240 


Met Leu Gln Lys Ala Ala Arg Gly Arg Glu Glu His Gly Asp Glu 
                245                 250                 255 


<210>  8
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Pro Arg Glu Asp Ala His Phe Ile Tyr Gly Tyr Pro Lys Lys Gly 
1               5                   10                  15      


His Gly His Ser Tyr Thr Thr Ala Glu Glu Ala Ala Gly Ile Gly Ile 
            20                  25                  30          


Leu Thr Val Ile Leu Gly Val Leu Leu Leu Ile Gly Cys Trp Tyr Cys 
        35                  40                  45              


Arg Arg Arg Asn Gly Tyr Arg Ala Leu Met Asp Lys Ser Leu His Val 
    50                  55                  60                  


Gly Thr Gln Cys Ala Leu Thr Arg Arg Cys Pro Gln Glu Gly Phe Asp 
65                  70                  75                  80  


His Arg Asp Ser Lys Val Ser Leu Gln Glu Lys Asn Cys Glu Pro Val 
                85                  90                  95      


Val Pro Asn Ala Pro Pro Ala Tyr Glu Lys Leu Ser Ala Glu Gln Ser 
            100                 105                 110         


Pro Pro Pro Tyr Ser Pro 
        115             


<210>  9
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Gln Ala Glu Gly Arg Gly Thr Gly Gly Ser Thr Gly Asp Ala Asp 
1               5                   10                  15      


Gly Pro Gly Gly Pro Gly Ile Pro Asp Gly Pro Gly Gly Asn Ala Gly 
            20                  25                  30          


Gly Pro Gly Glu Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala 
        35                  40                  45              


Gly Ala Ala Arg Ala Ser Gly Pro Gly Gly Gly Ala Pro Arg Gly Pro 
    50                  55                  60                  


His Gly Gly Ala Ala Ser Gly Leu Asn Gly Cys Cys Arg Cys Gly Ala 
65                  70                  75                  80  


Arg Gly Pro Glu Ser Arg Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe 
                85                  90                  95      


Ala Thr Pro Met Glu Ala Glu Leu Ala Arg Arg Ser Leu Ala Gln Asp 
            100                 105                 110         


Ala Pro Pro Leu Pro Val Pro Gly Val Leu Leu Lys Glu Phe Thr Val 
        115                 120                 125             


Ser Gly Asn Ile Leu Thr Ile Arg Leu Thr Ala Ala Asp His Arg Gln 
    130                 135                 140                 


Leu Gln Leu Ser Ile Ser Ser Cys Leu Gln Gln Leu Ser Leu Leu Met 
145                 150                 155                 160 


Trp Ile Thr Gln Cys Phe Leu Pro Val Phe Leu Ala Gln Pro Pro Ser 
                165                 170                 175     


Gly Gln Arg Arg 
            180 


<210>  10
<211>  661
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Asp Leu Val Leu Lys Arg Cys Leu Leu His Leu Ala Val Ile Gly 
1               5                   10                  15      


Ala Leu Leu Ala Val Gly Ala Thr Lys Val Pro Arg Asn Gln Asp Trp 
            20                  25                  30          


Leu Gly Val Ser Arg Gln Leu Arg Thr Lys Ala Trp Asn Arg Gln Leu 
        35                  40                  45              


Tyr Pro Glu Trp Thr Glu Ala Gln Arg Leu Asp Cys Trp Arg Gly Gly 
    50                  55                  60                  


Gln Val Ser Leu Lys Val Ser Asn Asp Gly Pro Thr Leu Ile Gly Ala 
65                  70                  75                  80  


Asn Ala Ser Phe Ser Ile Ala Leu Asn Phe Pro Gly Ser Gln Lys Val 
                85                  90                  95      


Leu Pro Asp Gly Gln Val Ile Trp Val Asn Asn Thr Ile Ile Asn Gly 
            100                 105                 110         


Ser Gln Val Trp Gly Gly Gln Pro Val Tyr Pro Gln Glu Thr Asp Asp 
        115                 120                 125             


Ala Cys Ile Phe Pro Asp Gly Gly Pro Cys Pro Ser Gly Ser Trp Ser 
    130                 135                 140                 


Gln Lys Arg Ser Phe Val Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp 
145                 150                 155                 160 


Gln Val Leu Gly Gly Pro Val Ser Gly Leu Ser Ile Gly Thr Gly Arg 
                165                 170                 175     


Ala Met Leu Gly Thr His Thr Met Glu Val Thr Val Tyr His Arg Arg 
            180                 185                 190         


Gly Ser Arg Ser Tyr Val Pro Leu Ala His Ser Ser Ser Ala Phe Thr 
        195                 200                 205             


Ile Thr Asp Gln Val Pro Phe Ser Val Ser Val Ser Gln Leu Arg Ala 
    210                 215                 220                 


Leu Asp Gly Gly Asn Lys His Phe Leu Arg Asn Gln Pro Leu Thr Phe 
225                 230                 235                 240 


Ala Leu Gln Leu His Asp Pro Ser Gly Tyr Leu Ala Glu Ala Asp Leu 
                245                 250                 255     


Ser Tyr Thr Trp Asp Phe Gly Asp Ser Ser Gly Thr Leu Ile Ser Arg 
            260                 265                 270         


Ala Leu Val Val Thr His Thr Tyr Leu Glu Pro Gly Pro Val Thr Ala 
        275                 280                 285             


Gln Val Val Leu Gln Ala Ala Ile Pro Leu Thr Ser Cys Gly Ser Ser 
    290                 295                 300                 


Pro Val Pro Gly Thr Thr Asp Gly His Arg Pro Thr Ala Glu Ala Pro 
305                 310                 315                 320 


Asn Thr Thr Ala Gly Gln Val Pro Thr Thr Glu Val Val Gly Thr Thr 
                325                 330                 335     


Pro Gly Gln Ala Pro Thr Ala Glu Pro Ser Gly Thr Thr Ser Val Gln 
            340                 345                 350         


Val Pro Thr Thr Glu Val Ile Ser Thr Ala Pro Val Gln Met Pro Thr 
        355                 360                 365             


Ala Glu Ser Thr Gly Met Thr Pro Glu Lys Val Pro Val Ser Glu Val 
    370                 375                 380                 


Met Gly Thr Thr Leu Ala Glu Met Ser Thr Pro Glu Ala Thr Gly Met 
385                 390                 395                 400 


Thr Pro Ala Glu Val Ser Ile Val Val Leu Ser Gly Thr Thr Ala Ala 
                405                 410                 415     


Gln Val Thr Thr Thr Glu Trp Val Glu Thr Thr Ala Arg Glu Leu Pro 
            420                 425                 430         


Ile Pro Glu Pro Glu Gly Pro Asp Ala Ser Ser Ile Met Ser Thr Glu 
        435                 440                 445             


Ser Ile Thr Gly Ser Leu Gly Pro Leu Leu Asp Gly Thr Ala Thr Leu 
    450                 455                 460                 


Arg Leu Val Lys Arg Gln Val Pro Leu Asp Cys Val Leu Tyr Arg Tyr 
465                 470                 475                 480 


Gly Ser Phe Ser Val Thr Leu Asp Ile Val Gln Gly Ile Glu Ser Ala 
                485                 490                 495     


Glu Ile Leu Gln Ala Val Pro Ser Gly Glu Gly Asp Ala Phe Glu Leu 
            500                 505                 510         


Thr Val Ser Cys Gln Gly Gly Leu Pro Lys Glu Ala Cys Met Glu Ile 
        515                 520                 525             


Ser Ser Pro Gly Cys Gln Pro Pro Ala Gln Arg Leu Cys Gln Pro Val 
    530                 535                 540                 


Leu Pro Ser Pro Ala Cys Gln Leu Val Leu His Gln Ile Leu Lys Gly 
545                 550                 555                 560 


Gly Ser Gly Thr Tyr Cys Leu Asn Val Ser Leu Ala Asp Thr Asn Ser 
                565                 570                 575     


Leu Ala Val Val Ser Thr Gln Leu Ile Met Pro Gly Gln Glu Ala Gly 
            580                 585                 590         


Leu Gly Gln Val Pro Leu Ile Val Gly Ile Leu Leu Val Leu Met Ala 
        595                 600                 605             


Val Val Leu Ala Ser Leu Ile Tyr Arg Arg Arg Leu Met Lys Gln Asp 
    610                 615                 620                 


Phe Ser Val Pro Gln Leu Pro His Ser Ser Ser His Trp Leu Arg Leu 
625                 630                 635                 640 


Pro Arg Ile Phe Cys Ser Cys Pro Ile Gly Glu Asn Ser Pro Leu Leu 
                645                 650                 655     


Ser Gly Gln Gln Val 
            660     


<210>  11
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Leu Leu Ala Val Leu Tyr Cys Leu Leu Trp Ser Phe Gln Thr Ser 
1               5                   10                  15      


Ala Gly His Phe Pro Arg Ala Cys Val Ser Ser Lys Asn Leu Met Glu 
            20                  25                  30          


Lys Glu Cys Cys Pro Pro Trp Ser Gly Asp Arg Ser Pro Cys Gly Gln 
        35                  40                  45              


Leu Ser Gly Arg Gly Ser Cys Gln Asn Ile Leu Leu Ser Asn Ala Pro 
    50                  55                  60                  


Leu Gly Pro Gln Phe Pro Phe Thr Gly Val Asp Asp Arg Glu Ser Trp 
65                  70                  75                  80  


Pro Ser Val Phe Tyr Asn Arg Thr Cys Gln Cys Ser Gly Asn Phe Met 
                85                  90                  95      


Gly Phe Asn Cys Gly Asn Cys Lys Phe Gly Phe Trp Gly Pro Asn Cys 
            100                 105                 110         


Thr Glu Arg Arg Leu Leu Val Arg Arg Asn Ile Phe Asp Leu Ser Ala 
        115                 120                 125             


Pro Glu Lys Asp Lys Phe Phe Ala Tyr Leu Thr Leu Ala Lys His Thr 
    130                 135                 140                 


Ile Ser Ser Asp Tyr Val Ile Pro Ile Gly Thr Tyr Gly Gln Met Lys 
145                 150                 155                 160 


Asn Gly Ser Thr Pro Met Phe Asn Asp Ile Asn Ile Tyr Asp Leu Phe 
                165                 170                 175     


Val Trp Met His Tyr Tyr Val Ser Met Asp Ala Leu Leu Gly Gly Ser 
            180                 185                 190         


Glu Ile Trp Arg Asp Ile Asp Phe Ala His Glu Ala Pro Ala Phe Leu 
        195                 200                 205             


Pro Trp His Arg Leu Phe Leu Leu Arg Trp Glu Gln Glu Ile Gln Lys 
    210                 215                 220                 


Leu Thr Gly Asp Glu Asn Phe Thr Ile Pro Tyr Trp Asp Trp Arg Asp 
225                 230                 235                 240 


Ala Glu Lys Cys Asp Ile Cys Thr Asp Glu Tyr Met Gly Gly Gln His 
                245                 250                 255     


Pro Thr Asn Pro Asn Leu Leu Ser Pro Ala Ser Phe Phe Ser Ser Trp 
            260                 265                 270         


Gln Ile Val Cys Ser Arg Leu Glu Glu Tyr Asn Ser His Gln Ser Leu 
        275                 280                 285             


Cys Asn Gly Thr Pro Glu Gly Pro Leu Arg Arg Asn Pro Gly Asn His 
    290                 295                 300                 


Asp Lys Ser Arg Thr Pro Arg Leu Pro Ser Ser Ala Asp Val Glu Phe 
305                 310                 315                 320 


Cys Leu Ser Leu Thr Gln Tyr Glu Ser Gly Ser Met Asp Lys Ala Ala 
                325                 330                 335     


Asn Phe Ser Phe Arg Asn Thr Leu Glu Gly Phe Ala Ser Pro Leu Thr 
            340                 345                 350         


Gly Ile Ala Asp Ala Ser Gln Ser Ser Met His Asn Ala Leu His Ile 
        355                 360                 365             


Tyr Met Asn Gly Thr Met Ser Gln Val Gln Gly Ser Ala Asn Asp Pro 
    370                 375                 380                 


Ile Phe Leu Leu His His Ala Phe Val Asp Ser Ile Phe Glu Gln Trp 
385                 390                 395                 400 


Leu Arg Arg His Arg Pro Leu Gln Glu Val Tyr Pro Glu Ala Asn Ala 
                405                 410                 415     


Pro Ile Gly His Asn Arg Glu Ser Tyr Met Val Pro Phe Ile Pro Leu 
            420                 425                 430         


Tyr Arg Asn Gly Asp Phe Phe Ile Ser Ser Lys Asp Leu Gly Tyr Asp 
        435                 440                 445             


Tyr Ser Tyr Leu Gln Asp Ser Asp Pro Asp Ser Phe Gln Asp Tyr Ile 
    450                 455                 460                 


Lys Ser Tyr Leu Glu Gln Ala Ser Arg Ile Trp Ser Trp Leu Leu Gly 
465                 470                 475                 480 


Ala Ala Met Val Gly Ala Val Leu Thr Ala Leu Leu Ala Gly Leu Val 
                485                 490                 495     


Ser Leu Leu Cys Arg His Lys Arg Lys Gln Leu Pro Glu Glu Lys Gln 
            500                 505                 510         


Pro Leu Leu Met Glu Lys Glu Asp Tyr His Ser Leu Tyr Gln Ser His 
        515                 520                 525             


Leu 
    


<210>  12
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu 
1               5                   10                  15      


Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala 
            20                  25                  30          


Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val 
        35                  40                  45              


Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser 
    50                  55                  60                  


Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp 
65                  70                  75                  80  


Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser 
                85                  90                  95      


Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys 
            100                 105                 110         


Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu 
        115                 120                 125             


Pro Val Thr Lys Ala Glu Met Leu Gly Ser Val Val Gly Asn Trp Gln 
    130                 135                 140                 


Tyr Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Ser Ser Leu Gln Leu 
145                 150                 155                 160 


Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Leu Tyr 
                165                 170                 175     


Ile Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp 
            180                 185                 190         


Asn Gln Ile Met Pro Lys Ala Gly Leu Leu Ile Ile Val Leu Ala Ile 
        195                 200                 205             


Ile Ala Arg Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu 
    210                 215                 220                 


Leu Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Ile Leu Gly 
225                 230                 235                 240 


Asp Pro Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu 
                245                 250                 255     


Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu 
            260                 265                 270         


Trp Gly Pro Arg Ala Leu Val Glu Thr Ser Tyr Val Lys Val Leu His 
        275                 280                 285             


His Met Val Lys Ile Ser Gly Gly Pro His Ile Ser Tyr Pro Pro Leu 
    290                 295                 300                 


His Glu Trp Val Leu Arg Glu Gly Glu Glu 
305                 310                 


<210>  13
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Thr Ser Arg Tyr Glu Pro Val Ala Glu Ile Gly Val Gly Ala 
1               5                   10                  15      


Tyr Gly Thr Val Tyr Lys Ala Arg Asp Pro His Ser Gly His Phe Val 
            20                  25                  30          


Ala Leu Lys Ser Val Arg Val Pro Asn Gly Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Leu Pro Ile Ser Thr Val Arg Glu Val Ala Leu Leu Arg Arg Leu Glu 
    50                  55                  60                  


Ala Phe Glu His Pro Asn Val Val Arg Leu Met Asp Val Cys Ala Thr 
65                  70                  75                  80  


Ser Arg Thr Asp Arg Glu Ile Lys Val Thr Leu Val Phe Glu His Val 
                85                  90                  95      


Asp Gln Asp Leu Arg Thr Tyr Leu Asp Lys Ala Pro Pro Pro Gly Leu 
            100                 105                 110         


Pro Ala Glu Thr Ile Lys Asp Leu Met Arg Gln Phe Leu Arg Gly Leu 
        115                 120                 125             


Asp Phe Leu His Ala Asn Cys Ile Val His Arg Asp Leu Lys Pro Glu 
    130                 135                 140                 


Asn Ile Leu Val Thr Ser Gly Gly Thr Val Lys Leu Ala Asp Phe Gly 
145                 150                 155                 160 


Leu Ala Arg Ile Tyr Ser Tyr Gln Met Ala Leu Thr Pro Val Val Val 
                165                 170                 175     


Thr Leu Trp Tyr Arg Ala Pro Glu Val Leu Leu Gln Ser Thr Tyr Ala 
            180                 185                 190         


Thr Pro Val Asp Met Trp Ser Val Gly Cys Ile Phe Ala Glu Met Phe 
        195                 200                 205             


Arg Arg Lys Pro Leu Phe Cys Gly Asn Ser Glu Ala Asp Gln Leu Gly 
    210                 215                 220                 


Lys Ile Phe Asp Leu Ile Gly Leu Pro Pro Glu Asp Asp Trp Pro Arg 
225                 230                 235                 240 


Asp Val Ser Leu Pro Arg Gly Ala Phe Pro Pro Arg Gly Pro Arg Pro 
                245                 250                 255     


Val Gln Ser Val Val Pro Glu Met Glu Glu Ser Gly Ala Gln Leu Leu 
            260                 265                 270         


Leu Glu Met Leu Thr Phe Asn Pro His Lys Arg Ile Ser Ala Phe Arg 
        275                 280                 285             


Ala Leu Gln His Ser Tyr Leu His Lys Asp Glu Gly Asn Pro Glu 
    290                 295                 300             


<210>  14
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Asp Lys Pro Asp Met Gly Glu Ile Ala Ser Phe Asp Lys Ala 
1               5                   10                  15      


Lys Leu Lys Lys Thr Glu Thr Gln Glu Lys Asn Thr Leu Pro Thr Lys 
            20                  25                  30          


Glu Thr Ile Glu Gln Glu Lys Arg Ser Glu Ile Ser 
        35                  40                  


<210>  15
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ser Leu Glu Gln Arg Ser Leu His Cys Lys Pro Glu Glu Ala Leu 
1               5                   10                  15      


Glu Ala Gln Gln Glu Ala Leu Gly Leu Val Cys Val Gln Ala Ala Thr 
            20                  25                  30          


Ser Ser Ser Ser Pro Leu Val Leu Gly Thr Leu Glu Glu Val Pro Thr 
        35                  40                  45              


Ala Gly Ser Thr Asp Pro Pro Gln Ser Pro Gln Gly Ala Ser Ala Phe 
    50                  55                  60                  


Pro Thr Thr Ile Asn Phe Thr Arg Gln Arg Gln Pro Ser Glu Gly Ser 
65                  70                  75                  80  


Ser Ser Arg Glu Glu Glu Gly Pro Ser Thr Ser Cys Ile Leu Glu Ser 
                85                  90                  95      


Leu Phe Arg Ala Val Ile Thr Lys Lys Val Ala Asp Leu Val Gly Phe 
            100                 105                 110         


Leu Leu Leu Lys Tyr Arg Ala Arg Glu Pro Val Thr Lys Ala Glu Met 
        115                 120                 125             


Leu Glu Ser Val Ile Lys Asn Tyr Lys His Cys Phe Pro Glu Ile Phe 
    130                 135                 140                 


Gly Lys Ala Ser Glu Ser Leu Gln Leu Val Phe Gly Ile Asp Val Lys 
145                 150                 155                 160 


Glu Ala Asp Pro Thr Gly His Ser Tyr Val Leu Val Thr Cys Leu Gly 
                165                 170                 175     


Leu Ser Tyr Asp Gly Leu Leu Gly Asp Asn Gln Ile Met Pro Lys Thr 
            180                 185                 190         


Gly Phe Leu Ile Ile Val Leu Val Met Ile Ala Met Glu Gly Gly His 
        195                 200                 205             


Ala Pro Glu Glu Glu Ile Trp Glu Glu Leu Ser Val Met Glu Val Tyr 
    210                 215                 220                 


Asp Gly Arg Glu His Ser Ala Tyr Gly Glu Pro Arg Lys Leu Leu Thr 
225                 230                 235                 240 


Gln Asp Leu Val Gln Glu Lys Tyr Leu Glu Tyr Arg Gln Val Pro Asp 
                245                 250                 255     


Ser Asp Pro Ala Arg Tyr Glu Phe Leu Trp Gly Pro Arg Ala Leu Ala 
            260                 265                 270         


Glu Thr Ser Tyr Val Lys Val Leu Glu Tyr Val Ile Lys Val Ser Ala 
        275                 280                 285             


Arg Val Arg Phe Phe Phe Pro Ser Leu Arg Glu Ala Ala Leu Arg Glu 
    290                 295                 300                 


Glu Glu Glu Gly Val 
305                 


<210>  16
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala His Phe Pro Gly Phe Gly Gln Ser Leu Leu Phe Gly Tyr Pro 
1               5                   10                  15      


Val Tyr Val Phe Gly Asp Cys Val Gln Gly Asp Trp Cys Pro Ile Ser 
            20                  25                  30          


Gly Gly Leu Cys Ser Ala Arg Leu His Arg His Ala Leu Leu Ala Thr 
        35                  40                  45              


Cys Pro Glu His Gln Ile Thr Trp Asp Pro Ile Asp Gly Arg Val Ile 
    50                  55                  60                  


Gly Ser Ala Leu Gln Phe Leu Ile Pro Arg Leu Pro Ser Phe Pro Thr 
65                  70                  75                  80  


Gln Arg Thr Ser Lys Thr Leu Lys Val Leu Thr Pro Pro Ile Thr His 
                85                  90                  95      


Thr Thr Pro Asn Ile Pro Pro Ser Phe Leu Gln Ala Met Arg Lys Tyr 
            100                 105                 110         


Ser Pro Phe Arg Asn Gly Tyr Met Glu Pro Thr Leu Gly Gln His Leu 
        115                 120                 125             


Pro Thr Leu Ser Phe Pro Asp Pro Gly Leu Arg Pro Gln Asn Leu Tyr 
    130                 135                 140                 


Thr Leu Trp Gly Gly Ser Val Val Cys Met Tyr Leu Tyr Gln Leu Ser 
145                 150                 155                 160 


Pro Pro Ile Thr Trp Pro Leu Leu Pro His Val Ile Phe Cys His Pro 
                165                 170                 175     


Gly Gln Leu Gly Ala Phe Leu Thr Asn Val Pro Tyr Lys Arg Ile Glu 
            180                 185                 190         


Glu Leu Leu Tyr Lys Ile Ser Leu Thr Thr Gly Ala Leu Ile Ile Leu 
        195                 200                 205             


Pro Glu Asp Cys Leu Pro Thr Thr Leu Phe Gln Pro Ala Arg Ala Pro 
    210                 215                 220                 


Val Thr Leu Thr Ala Trp Gln Asn Gly Leu Leu Pro Phe His Ser Thr 
225                 230                 235                 240 


Leu Thr Thr Pro Gly Leu Ile Trp Thr Phe Thr Asp Gly Thr Pro Met 
                245                 250                 255     


Ile Ser Gly Pro Cys Pro Lys Asp Gly Gln Pro Ser Leu Val Leu Gln 
            260                 265                 270         


Ser Ser Ser Phe Ile Phe His Lys Phe Gln Thr Lys Ala Tyr His Pro 
        275                 280                 285             


Ser Phe Leu Leu Ser His Gly Leu Ile Gln Tyr Ser Ser Phe His Ser 
    290                 295                 300                 


Leu His Leu Leu Phe Glu Glu Tyr Thr Asn Ile Pro Ile Ser Leu Leu 
305                 310                 315                 320 


Phe Asn Glu Lys Glu Ala Asp Asp Asn Asp His Glu Pro Gln Ile Ser 
                325                 330                 335     


Pro Gly Gly Leu Glu Pro Pro Ser Glu Lys His Phe Arg Glu Thr Glu 
            340                 345                 350         


Val 
    


<210>  17
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Gly Ser Leu Glu Met Val Pro Met Gly Ala Gly Pro Pro Ser Pro 
1               5                   10                  15      


Gly Gly Asp Pro Asp Gly Tyr Asp Gly Gly Asn Asn Ser Gln Tyr Pro 
            20                  25                  30          


Ser Ala Ser Gly Ser Ser Gly Asn Thr Pro Thr Pro Pro Asn Asp Glu 
        35                  40                  45              


Glu Arg Glu Ser Asn Glu Glu Pro Pro Pro Pro Tyr Glu Asp Pro Tyr 
    50                  55                  60                  


Trp Gly Asn Gly Asp Arg His Ser Asp Tyr Gln Pro Leu Gly Thr Gln 
65                  70                  75                  80  


Asp Gln Ser Leu Tyr Leu Gly Leu Gln His Asp Gly Asn Asp Gly Leu 
                85                  90                  95      


Pro Pro Pro Pro Tyr Ser Pro Arg Asp Asp Ser Ser Gln His Ile Tyr 
            100                 105                 110         


Glu Glu Ala Gly Arg Gly Ser Met Asn Pro Val Cys Leu Pro Val Ile 
        115                 120                 125             


Val Ala Pro Tyr Leu Phe Trp Leu Ala Ala Ile Ala Ala Ser Cys Phe 
    130                 135                 140                 


Thr Ala Ser Val Ser Thr Val Val Thr Ala Thr Gly Leu Ala Leu Ser 
145                 150                 155                 160 


Leu Leu Leu Leu Ala Ala Val Ala Ser Ser Tyr Ala Ala Ala Gln Arg 
                165                 170                 175     


Lys Leu Leu Thr Pro Val Thr Val Leu Thr Ala Val Val Thr Phe Phe 
            180                 185                 190         


Ala Ile Cys Leu Thr Trp Arg Ile Glu Asp Pro Pro Phe Asn Ser Leu 
        195                 200                 205             


Leu Phe Ala Leu Leu Ala Ala Ala Gly Gly Leu Gln Gly Ile Tyr Val 
    210                 215                 220                 


Leu Val Met Leu Val Leu Leu Ile Leu Ala Tyr Arg Arg Arg Trp Arg 
225                 230                 235                 240 


Arg Leu Thr Val Cys Gly Gly Ile Met Phe Leu Ala Cys Val Leu Val 
                245                 250                 255     


Leu Ile Val Asp Ala Val Leu Gln Leu Ser Pro Leu Leu Gly Ala Val 
            260                 265                 270         


Thr Val Val Ser Met Thr Leu Leu Leu Leu Ala Phe Val Leu Trp Leu 
        275                 280                 285             


Ser Ser Pro Gly Gly Leu Gly Thr Leu Gly Ala Ala Leu Leu Thr Leu 
    290                 295                 300                 


Ala Ala Ala Leu Ala Leu Leu Ala Ser Leu Ile Leu Gly Thr Leu Asn 
305                 310                 315                 320 


Leu Thr Thr Met Phe Leu Leu Met Leu Leu Trp Thr Leu Val Val Leu 
                325                 330                 335     


Leu Ile Cys Ser Ser Cys Ser Ser Cys Pro Leu Ser Lys Ile Leu Leu 
            340                 345                 350         


Ala Arg Leu Phe Leu Tyr Ala Leu Ala Leu Leu Leu Leu Ala Ser Ala 
        355                 360                 365             


Leu Ile Ala Gly Gly Ser Ile Leu Gln Thr Asn Phe Lys Ser Leu Ser 
    370                 375                 380                 


Ser Thr Glu Phe Ile Pro Asn Leu Phe Cys Met Leu Leu Leu Ile Val 
385                 390                 395                 400 


Ala Gly Ile Leu Phe Ile Leu Ala Ile Leu Thr Glu Trp Gly Ser Gly 
                405                 410                 415     


Asn Arg Thr Tyr Gly Pro Val Phe Met Cys Leu Gly Gly Leu Leu Thr 
            420                 425                 430         


Met Val Ala Gly Ala Val Trp Leu Thr Val Met Ser Asn Thr Leu Leu 
        435                 440                 445             


Ser Ala Trp Ile Leu Thr Ala Gly Phe Leu Ile Phe Leu Ile Gly Phe 
    450                 455                 460                 


Ala Leu Phe Gly Val Ile Arg Cys Cys Arg Tyr Cys Cys Tyr Tyr Cys 
465                 470                 475                 480 


Leu Thr Leu Glu Ser Glu Glu Arg Pro Pro Thr Pro Tyr Arg Asn Thr 
                485                 490                 495     


Val 
    


<210>  18
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala His Arg Pro Pro Ser Pro Ala Leu Ala Ser Val Leu Leu Ala 
1               5                   10                  15      


Leu Leu Leu Ser Gly Ala Ala Arg Ala Ala Glu Ile Val Gly Gly His 
            20                  25                  30          


Glu Ala Gln Pro His Ser Arg Pro Tyr Met Ala Ser Leu Gln Met Arg 
        35                  40                  45              


Gly Asn Pro Gly Ser His Phe Cys Gly Gly Thr Leu Ile His Pro Ser 
    50                  55                  60                  


Phe Val Leu Thr Ala Ala His Cys Leu Arg Asp Ile Pro Gln Arg Leu 
65                  70                  75                  80  


Val Asn Val Val Leu Gly Ala His Asn Val Arg Thr Gln Glu Pro Thr 
                85                  90                  95      


Gln Gln His Phe Ser Val Ala Gln Val Phe Leu Asn Asn Tyr Asp Ala 
            100                 105                 110         


Glu Asn Lys Leu Asn Asp Val Leu Leu Ile Gln Leu Ser Ser Pro Ala 
        115                 120                 125             


Asn Leu Ser Ala Ser Val Ala Thr Val Gln Leu Pro Gln Gln Asp Gln 
    130                 135                 140                 


Pro Val Pro His Gly Thr Gln Cys Leu Ala Met Gly Trp Gly Arg Val 
145                 150                 155                 160 


Gly Ala His Asp Pro Pro Ala Gln Val Leu Gln Glu Leu Asn Val Thr 
                165                 170                 175     


Val Val Thr Phe Phe Cys Arg Pro His Asn Ile Cys Thr Phe Val Pro 
            180                 185                 190         


Arg Arg Lys Ala Gly Ile Cys Phe Gly Asp Ser Gly Gly Pro Leu Ile 
        195                 200                 205             


Cys Asp Gly Ile Ile Gln Gly Ile Asp Ser Phe Val Ile Trp Gly Cys 
    210                 215                 220                 


Ala Thr Arg Leu Phe Pro Asp Phe Phe Thr Arg Val Ala Leu Tyr Val 
225                 230                 235                 240 


Asp Trp Ile Arg Ser Thr Leu Arg Arg Val Glu Ala Lys Gly Arg Pro 
                245                 250                 255     


<210>  19
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Gly Ser Asp Val Arg Asp Leu Asn Ala Leu Leu Pro Ala Val Pro 
1               5                   10                  15      


Ser Leu Gly Gly Gly Gly Gly Cys Ala Leu Pro Val Ser Gly Ala Ala 
            20                  25                  30          


Gln Trp Ala Pro Val Leu Asp Phe Ala Pro Pro Gly Ala Ser Ala Tyr 
        35                  40                  45              


Gly Ser Leu Gly Gly Pro Ala Pro Pro Pro Ala Pro Pro Pro Pro Pro 
    50                  55                  60                  


Pro Pro Pro Pro His Ser Phe Ile Lys Gln Glu Pro Ser Trp Gly Gly 
65                  70                  75                  80  


Ala Glu Pro His Glu Glu Gln Cys Leu Ser Ala Phe Thr Val His Phe 
                85                  90                  95      


Ser Gly Gln Phe Thr Gly Thr Ala Gly Ala Cys Arg Tyr Gly Pro Phe 
            100                 105                 110         


Gly Pro Pro Pro Pro Ser Gln Ala Ser Ser Gly Gln Ala Arg Met Phe 
        115                 120                 125             


Pro Asn Ala Pro Tyr Leu Pro Ser Cys Leu Glu Ser Gln Pro Ala Ile 
    130                 135                 140                 


Arg Asn Gln Gly Tyr Ser Thr Val Thr Phe Asp Gly Thr Pro Ser Tyr 
145                 150                 155                 160 


Gly His Thr Pro Ser His His Ala Ala Gln Phe Pro Asn His Ser Phe 
                165                 170                 175     


Lys His Glu Asp Pro Met Gly Gln Gln Gly Ser Leu Gly Glu Gln Gln 
            180                 185                 190         


Tyr Ser Val Pro Pro Pro Val Tyr Gly Cys His Thr Pro Thr Asp Ser 
        195                 200                 205             


Cys Thr Gly Ser Gln Ala Leu Leu Leu Arg Thr Pro Tyr Ser Ser Asp 
    210                 215                 220                 


Asn Leu Tyr Gln Met Thr Ser Gln Leu Glu Cys Met Thr Trp Asn Gln 
225                 230                 235                 240 


Met Asn Leu Gly Ala Thr Leu Lys Gly Val Ala Ala Gly Ser Ser Ser 
                245                 250                 255     


Ser Val Lys Trp Thr Glu Gly Gln Ser Asn His Ser Thr Gly Tyr Glu 
            260                 265                 270         


Ser Asp Asn His Thr Thr Pro Ile Leu Cys Gly Ala Gln Tyr Arg Ile 
        275                 280                 285             


His Thr His Gly Val Phe Arg Gly Ile Gln Asp Val Arg Arg Val Pro 
    290                 295                 300                 


Gly Val Ala Pro Thr Leu Val Arg Ser Ala Ser Glu Thr Ser Glu Lys 
305                 310                 315                 320 


Arg Pro Phe Met Cys Ala Tyr Pro Gly Cys Asn Lys Arg Tyr Phe Lys 
                325                 330                 335     


Leu Ser His Leu Gln Met His Ser Arg Lys His Thr Gly Glu Lys Pro 
            340                 345                 350         


Tyr Gln Cys Asp Phe Lys Asp Cys Glu Arg Arg Phe Ser Arg Ser Asp 
        355                 360                 365             


Gln Leu Lys Arg His Gln Arg Arg His Thr Gly Val Lys Pro Phe Gln 
    370                 375                 380                 


Cys Lys Thr Cys Gln Arg Lys Phe Ser Arg Ser Asp His Leu Lys Thr 
385                 390                 395                 400 


His Thr Arg Thr His Thr Gly Lys Thr Ser Glu Lys Pro Phe Ser Cys 
                405                 410                 415     


Arg Trp Pro Ser Cys Gln Lys Lys Phe Ala Arg Ser Asp Glu Leu Val 
            420                 425                 430         


Arg His His Asn Met His Gln Arg Asn Met Thr Lys Leu Gln Leu Ala 
        435                 440                 445             


Leu 
    


<210>  20
<211>  561
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Glu Ser Arg Gly Arg Arg Cys Pro Glu Met Ile Ser Val Leu Gly 
1               5                   10                  15      


Pro Ile Ser Gly His Val Leu Lys Ala Val Phe Ser Arg Gly Asp Thr 
            20                  25                  30          


Pro Val Leu Pro His Glu Thr Arg Leu Leu Gln Thr Gly Ile His Val 
        35                  40                  45              


Arg Val Ser Gln Pro Ser Leu Ile Leu Val Ser Gln Tyr Thr Pro Asp 
    50                  55                  60                  


Ser Thr Pro Cys His Arg Gly Asp Asn Gln Leu Gln Val Gln His Thr 
65                  70                  75                  80  


Tyr Phe Thr Gly Ser Glu Val Glu Asn Val Ser Val Asn Val His Asn 
                85                  90                  95      


Pro Thr Gly Arg Ser Ile Cys Pro Ser Gln Glu Pro Met Ser Ile Tyr 
            100                 105                 110         


Val Tyr Ala Leu Pro Leu Lys Met Leu Asn Ile Pro Ser Ile Asn Val 
        115                 120                 125             


His His Tyr Pro Ser Ala Ala Glu Arg Lys His Arg His Leu Pro Val 
    130                 135                 140                 


Ala Asp Ala Val Ile His Ala Ser Gly Lys Gln Met Trp Gln Ala Arg 
145                 150                 155                 160 


Leu Thr Val Ser Gly Leu Ala Trp Thr Arg Gln Gln Asn Gln Trp Lys 
                165                 170                 175     


Glu Pro Asp Val Tyr Tyr Thr Ser Ala Phe Val Phe Pro Thr Lys Asp 
            180                 185                 190         


Val Ala Leu Arg His Val Val Cys Ala His Glu Leu Val Cys Ser Met 
        195                 200                 205             


Glu Asn Thr Arg Ala Thr Lys Met Gln Val Ile Gly Asp Gln Tyr Val 
    210                 215                 220                 


Lys Val Tyr Leu Glu Ser Phe Cys Glu Asp Val Pro Ser Gly Lys Leu 
225                 230                 235                 240 


Phe Met His Val Thr Leu Gly Ser Asp Val Glu Glu Asp Leu Thr Met 
                245                 250                 255     


Thr Arg Asn Pro Gln Pro Phe Met Arg Pro His Glu Arg Asn Gly Phe 
            260                 265                 270         


Thr Val Leu Cys Pro Lys Asn Met Ile Ile Lys Pro Gly Lys Ile Ser 
        275                 280                 285             


His Ile Met Leu Asp Val Ala Phe Thr Ser His Glu His Phe Gly Leu 
    290                 295                 300                 


Leu Cys Pro Lys Ser Ile Pro Gly Leu Ser Ile Ser Gly Asn Leu Leu 
305                 310                 315                 320 


Met Asn Gly Gln Gln Ile Phe Leu Glu Val Gln Ala Ile Arg Glu Thr 
                325                 330                 335     


Val Glu Leu Arg Gln Tyr Asp Pro Val Ala Ala Leu Phe Phe Phe Asp 
            340                 345                 350         


Ile Asp Leu Leu Leu Gln Arg Gly Pro Gln Tyr Ser Glu His Pro Thr 
        355                 360                 365             


Phe Thr Ser Gln Tyr Arg Ile Gln Gly Lys Leu Glu Tyr Arg His Thr 
    370                 375                 380                 


Trp Asp Arg His Asp Glu Gly Ala Ala Gln Gly Asp Asp Asp Val Trp 
385                 390                 395                 400 


Thr Ser Gly Ser Asp Ser Asp Glu Glu Leu Val Thr Thr Glu Arg Lys 
                405                 410                 415     


Thr Pro Arg Val Thr Gly Gly Gly Ala Met Ala Ser Ala Ser Thr Ser 
            420                 425                 430         


Ala Gly Arg Lys Arg Lys Ser Ala Ser Ser Ala Thr Ala Cys Thr Ala 
        435                 440                 445             


Gly Val Met Thr Arg Gly Arg Leu Lys Ala Glu Ser Thr Val Ala Pro 
    450                 455                 460                 


Glu Glu Asp Thr Asp Glu Asp Ser Asp Asn Glu Ile His Asn Pro Ala 
465                 470                 475                 480 


Val Phe Thr Trp Pro Pro Trp Gln Ala Gly Ile Leu Ala Arg Asn Leu 
                485                 490                 495     


Val Pro Met Val Ala Thr Val Gln Gly Gln Asn Leu Lys Tyr Gln Glu 
            500                 505                 510         


Phe Phe Trp Asp Ala Asn Asp Ile Tyr Arg Ile Phe Ala Glu Leu Glu 
        515                 520                 525             


Gly Val Trp Gln Pro Ala Ala Gln Pro Lys Arg Arg Arg His Arg Gln 
    530                 535                 540                 


Asp Ala Leu Pro Gly Pro Cys Ile Ala Ser Thr Pro Lys Lys His Arg 
545                 550                 555                 560 


Gly 
    


<210>  21
<211>  386
<212>  PRT
<213>  Epstein-Barr virus

<400>  21

Met Glu His Asp Leu Glu Arg Gly Pro Pro Gly Pro Arg Arg Pro Pro 
1               5                   10                  15      


Arg Gly Pro Pro Leu Ser Ser Ser Leu Gly Leu Ala Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Ala Leu Leu Phe Trp Leu Tyr Ile Val Met Ser Asp Trp Thr 
        35                  40                  45              


Gly Gly Ala Leu Leu Val Leu Tyr Ser Phe Ala Leu Met Leu Ile Ile 
    50                  55                  60                  


Ile Ile Leu Ile Ile Phe Ile Phe Arg Arg Asp Leu Leu Cys Pro Leu 
65                  70                  75                  80  


Gly Ala Leu Cys Ile Leu Leu Leu Met Ile Thr Leu Leu Leu Ile Ala 
                85                  90                  95      


Leu Trp Asn Leu His Gly Gln Ala Leu Phe Leu Gly Ile Val Leu Phe 
            100                 105                 110         


Ile Phe Gly Cys Leu Leu Val Leu Gly Ile Trp Ile Tyr Leu Leu Glu 
        115                 120                 125             


Met Leu Trp Arg Leu Gly Ala Thr Ile Trp Gln Leu Leu Ala Phe Phe 
    130                 135                 140                 


Leu Ala Phe Phe Leu Asp Leu Ile Leu Leu Ile Ile Ala Leu Tyr Leu 
145                 150                 155                 160 


Gln Gln Asn Trp Trp Thr Leu Leu Val Asp Leu Leu Trp Leu Leu Leu 
                165                 170                 175     


Phe Leu Ala Ile Leu Ile Trp Met Tyr Tyr His Gly Gln Arg His Ser 
            180                 185                 190         


Asp Glu His His His Asp Asp Ser Leu Pro His Pro Gln Gln Ala Thr 
        195                 200                 205             


Asp Asp Ser Gly His Glu Ser Asp Ser Asn Ser Asn Glu Gly Arg His 
    210                 215                 220                 


His Leu Leu Val Ser Gly Ala Gly Asp Gly Pro Pro Leu Cys Ser Gln 
225                 230                 235                 240 


Asn Leu Gly Ala Pro Gly Gly Gly Pro Asp Asn Gly Pro Gln Asp Pro 
                245                 250                 255     


Asp Asn Thr Asp Asp Asn Gly Pro Gln Asp Pro Asp Asn Thr Asp Asp 
            260                 265                 270         


Asn Gly Pro His Asp Pro Leu Pro Gln Asp Pro Asp Asn Thr Asp Asp 
        275                 280                 285             


Asn Gly Pro Gln Asp Pro Asp Asn Thr Asp Asp Asn Gly Pro His Asp 
    290                 295                 300                 


Pro Leu Pro His Ser Pro Ser Asp Ser Ala Gly Asn Asp Gly Gly Pro 
305                 310                 315                 320 


Pro Gln Leu Thr Glu Glu Val Glu Asn Lys Gly Gly Asp Gln Gly Pro 
                325                 330                 335     


Pro Leu Met Thr Asp Gly Gly Gly Gly His Ser His Asp Ser Gly His 
            340                 345                 350         


Gly Gly Gly Asp Pro His Leu Pro Thr Leu Leu Leu Gly Ser Ser Gly 
        355                 360                 365             


Ser Gly Gly Asp Asp Asp Asp Pro His Gly Pro Val Gln Leu Ser Tyr 
    370                 375                 380                 


Tyr Asp 
385     


<210>  22
<211>  944
<212>  PRT
<213>  Epstein-Barr virus

<400>  22

Met Asp Lys Asp Arg Pro Gly Pro Pro Ala Leu Asp Asp Asn Met Glu 
1               5                   10                  15      


Glu Glu Val Pro Ser Thr Ser Val Val Gln Glu Gln Val Ser Ala Gly 
            20                  25                  30          


Asp Trp Glu Asn Val Leu Ile Glu Leu Ser Asp Ser Ser Ser Glu Lys 
        35                  40                  45              


Glu Ala Glu Asp Ala His Leu Glu Pro Ala Gln Lys Gly Thr Lys Arg 
    50                  55                  60                  


Lys Arg Val Asp His Asp Ala Gly Gly Ser Ala Pro Ala Arg Pro Met 
65                  70                  75                  80  


Leu Pro Pro Gln Pro Asp Leu Pro Gly Arg Glu Ala Ile Leu Arg Arg 
                85                  90                  95      


Phe Pro Leu Asp Leu Arg Thr Leu Leu Gln Ala Ile Gly Ala Ala Ala 
            100                 105                 110         


Thr Arg Ile Asp Thr Arg Ala Ile Asp Gln Phe Phe Gly Ser Gln Ile 
        115                 120                 125             


Ser Asn Thr Glu Met Tyr Ile Met Tyr Ala Met Ala Ile Arg Gln Ala 
    130                 135                 140                 


Ile Arg Asp Arg Arg Arg Asn Pro Ala Ser Arg Arg Asp Gln Ala Lys 
145                 150                 155                 160 


Trp Arg Leu Gln Thr Leu Ala Ala Gly Trp Pro Met Gly Tyr Gln Ala 
                165                 170                 175     


Tyr Ser Ser Trp Met Tyr Ser Tyr Thr Asp His Gln Thr Thr Pro Thr 
            180                 185                 190         


Phe Val His Leu Gln Ala Thr Leu Gly Cys Thr Gly Gly Arg Arg Cys 
        195                 200                 205             


His Val Thr Phe Ser Ala Gly Thr Phe Lys Leu Pro Arg Cys Thr Pro 
    210                 215                 220                 


Gly Asp Arg Gln Trp Leu Tyr Val Gln Ser Ser Val Gly Asn Ile Val 
225                 230                 235                 240 


Gln Ser Cys Asn Pro Arg Tyr Ser Ile Phe Phe Asp Tyr Met Ala Ile 
                245                 250                 255     


His Arg Ser Leu Thr Lys Ile Trp Glu Glu Val Leu Thr Pro Asp Gln 
            260                 265                 270         


Arg Val Ser Phe Met Glu Phe Leu Gly Phe Leu Gln Arg Thr Asp Leu 
        275                 280                 285             


Ser Tyr Ile Lys Ser Phe Val Ser Asp Ala Leu Gly Thr Thr Ser Ile 
    290                 295                 300                 


Gln Thr Pro Trp Ile Asp Asp Asn Pro Ser Thr Glu Thr Ala Gln Ala 
305                 310                 315                 320 


Trp Asn Ala Gly Phe Leu Arg Gly Arg Ala Tyr Gly Ile Asp Leu Leu 
                325                 330                 335     


Arg Thr Glu Gly Glu His Val Glu Gly Ala Thr Gly Glu Thr Arg Glu 
            340                 345                 350         


Glu Ser Glu Asp Thr Glu Ser Asp Gly Asp Asp Glu Asp Leu Pro Cys 
        355                 360                 365             


Ile Val Ser Arg Gly Gly Pro Lys Val Lys Arg Pro Pro Ile Phe Ile 
    370                 375                 380                 


Arg Arg Leu His Arg Leu Leu Leu Met Arg Ala Gly Lys Arg Thr Glu 
385                 390                 395                 400 


Gln Gly Lys Glu Val Leu Glu Lys Ala Arg Gly Ser Thr Tyr Gly Thr 
                405                 410                 415     


Pro Arg Pro Pro Val Pro Lys Pro Arg Pro Glu Val Pro Gln Ser Asp 
            420                 425                 430         


Glu Thr Ala Thr Ser His Gly Ser Ala Gln Val Pro Glu Pro Pro Thr 
        435                 440                 445             


Ile His Leu Ala Ala Gln Gly Met Ala Tyr Pro Leu His Glu Gln His 
    450                 455                 460                 


Gly Met Ala Pro Cys Pro Val Ala Gln Ala Pro Pro Thr Pro Leu Pro 
465                 470                 475                 480 


Pro Val Ser Pro Gly Asp Gln Leu Pro Gly Val Phe Ser Asp Gly Arg 
                485                 490                 495     


Val Ala Cys Ala Pro Val Pro Ala Pro Ala Gly Pro Ile Val Arg Pro 
            500                 505                 510         


Trp Glu Pro Ser Leu Thr Gln Ala Ala Gly Gln Ala Phe Ala Pro Val 
        515                 520                 525             


Arg Pro Gln His Met Pro Val Glu Pro Val Pro Val Pro Thr Val Ala 
    530                 535                 540                 


Leu Glu Arg Pro Val Tyr Pro Lys Pro Val Arg Pro Ala Pro Pro Lys 
545                 550                 555                 560 


Ile Ala Met Gln Gly Pro Gly Glu Thr Ser Gly Ile Arg Arg Ala Arg 
                565                 570                 575     


Glu Arg Trp Arg Pro Ala Pro Trp Thr Pro Asn Pro Pro Arg Ser Pro 
            580                 585                 590         


Ser Gln Met Ser Val Arg Asp Arg Leu Ala Arg Leu Arg Ala Glu Ala 
        595                 600                 605             


Gln Val Lys Gln Ala Ser Val Glu Val Gln Pro Pro Gln Leu Thr Gln 
    610                 615                 620                 


Val Ser Pro Gln Gln Pro Met Glu Gly Pro Leu Val Pro Glu Gln Gln 
625                 630                 635                 640 


Met Phe Pro Gly Ala Pro Phe Ser Gln Val Ala Asp Val Val Arg Ala 
                645                 650                 655     


Pro Gly Val Pro Ala Met Gln Pro Gln Tyr Phe Asp Leu Pro Leu Ile 
            660                 665                 670         


Gln Pro Ile Ser Gln Gly Ala Pro Val Ala Pro Leu Arg Ala Ser Met 
        675                 680                 685             


Gly Pro Val Pro Pro Val Pro Ala Thr Gln Pro Gln Tyr Phe Asp Ile 
    690                 695                 700                 


Pro Leu Thr Glu Pro Ile Asn Gln Gly Ala Ser Ala Ala His Phe Leu 
705                 710                 715                 720 


Pro Gln Gln Pro Met Glu Gly Pro Leu Val Pro Glu Gln Trp Met Phe 
                725                 730                 735     


Pro Gly Ala Ala Leu Ser Gln Ser Val Arg Pro Gly Val Ala Gln Ser 
            740                 745                 750         


Gln Tyr Phe Asp Leu Pro Leu Thr Gln Pro Ile Asn His Gly Ala Pro 
        755                 760                 765             


Ala Ala His Phe Leu His Gln Pro Pro Met Glu Gly Pro Trp Val Pro 
    770                 775                 780                 


Glu Gln Trp Met Phe Gln Gly Ala Pro Pro Ser Gln Gly Thr Asp Val 
785                 790                 795                 800 


Val Gln His Gln Leu Asp Ala Leu Gly Tyr Thr Leu His Gly Leu Asn 
                805                 810                 815     


His Pro Gly Val Pro Val Ser Pro Ala Val Asn Gln Tyr His Leu Ser 
            820                 825                 830         


Gln Ala Ala Phe Gly Leu Pro Ile Asp Glu Asp Glu Ser Gly Glu Gly 
        835                 840                 845             


Ser Asp Thr Ser Glu Pro Cys Glu Ala Leu Asp Leu Ser Ile His Gly 
    850                 855                 860                 


Arg Pro Cys Pro Gln Ala Pro Glu Trp Pro Val Gln Glu Glu Gly Gly 
865                 870                 875                 880 


Gln Asp Ala Thr Glu Val Leu Asp Leu Ser Ile His Gly Arg Pro Arg 
                885                 890                 895     


Pro Arg Thr Pro Glu Trp Pro Val Gln Gly Glu Gly Gly Gln Asn Val 
            900                 905                 910         


Thr Gly Pro Glu Thr Arg Arg Val Val Val Ser Ala Val Val His Met 
        915                 920                 925             


Cys Gln Asp Asp Glu Phe Pro Asp Leu Gln Asp Pro Pro Asp Glu Ala 
    930                 935                 940                 


<210>  23
<211>  641
<212>  PRT
<213>  Epstein-Barr virus

<400>  23

Met Ser Asp Glu Gly Pro Gly Thr Gly Pro Gly Asn Gly Leu Gly Glu 
1               5                   10                  15      


Lys Gly Asp Thr Ser Gly Pro Glu Gly Ser Gly Gly Ser Gly Pro Gln 
            20                  25                  30          


Arg Arg Gly Gly Asp Asn His Gly Arg Gly Arg Gly Arg Gly Arg Gly 
        35                  40                  45              


Arg Gly Gly Gly Arg Pro Gly Ala Pro Gly Gly Ser Gly Ser Gly Pro 
    50                  55                  60                  


Arg His Arg Asp Gly Val Arg Arg Pro Gln Lys Arg Pro Ser Cys Ile 
65                  70                  75                  80  


Gly Cys Lys Gly Thr His Gly Gly Thr Gly Ala Gly Ala Gly Ala Gly 
                85                  90                  95      


Gly Ala Gly Ala Gly Gly Ala Gly Ala Gly Gly Gly Ala Gly Ala Gly 
            100                 105                 110         


Gly Gly Ala Gly Gly Ala Gly Gly Ala Gly Gly Ala Gly Ala Gly Gly 
        115                 120                 125             


Gly Ala Gly Ala Gly Gly Gly Ala Gly Gly Ala Gly Gly Ala Gly Ala 
    130                 135                 140                 


Gly Gly Gly Ala Gly Ala Gly Gly Gly Ala Gly Gly Ala Gly Ala Gly 
145                 150                 155                 160 


Gly Gly Ala Gly Gly Ala Gly Gly Ala Gly Ala Gly Gly Gly Ala Gly 
                165                 170                 175     


Ala Gly Gly Gly Ala Gly Gly Ala Gly Ala Gly Gly Gly Ala Gly Gly 
            180                 185                 190         


Ala Gly Gly Ala Gly Ala Gly Gly Gly Ala Gly Ala Gly Gly Ala Gly 
        195                 200                 205             


Gly Ala Gly Gly Ala Gly Ala Gly Gly Ala Gly Ala Gly Gly Gly Ala 
    210                 215                 220                 


Gly Gly Ala Gly Gly Ala Gly Ala Gly Gly Ala Gly Ala Gly Gly Ala 
225                 230                 235                 240 


Gly Ala Gly Gly Ala Gly Ala Gly Gly Ala Gly Gly Ala Gly Ala Gly 
                245                 250                 255     


Gly Ala Gly Gly Ala Gly Ala Gly Gly Ala Gly Gly Ala Gly Ala Gly 
            260                 265                 270         


Gly Gly Ala Gly Gly Ala Gly Ala Gly Gly Gly Ala Gly Gly Ala Gly 
        275                 280                 285             


Ala Gly Gly Ala Gly Gly Ala Gly Ala Gly Gly Ala Gly Gly Ala Gly 
    290                 295                 300                 


Ala Gly Gly Ala Gly Gly Ala Gly Ala Gly Gly Gly Ala Gly Ala Gly 
305                 310                 315                 320 


Gly Ala Gly Ala Gly Gly Gly Gly Arg Gly Arg Gly Gly Ser Gly Gly 
                325                 330                 335     


Arg Gly Arg Gly Gly Ser Gly Gly Arg Gly Arg Gly Gly Ser Gly Gly 
            340                 345                 350         


Arg Arg Gly Arg Gly Arg Glu Arg Ala Arg Gly Gly Ser Arg Glu Arg 
        355                 360                 365             


Ala Arg Gly Arg Gly Arg Gly Arg Gly Glu Lys Arg Pro Arg Ser Pro 
    370                 375                 380                 


Ser Ser Gln Ser Ser Ser Ser Gly Ser Pro Pro Arg Arg Pro Pro Pro 
385                 390                 395                 400 


Gly Arg Arg Pro Phe Phe His Pro Val Gly Glu Ala Asp Tyr Phe Glu 
                405                 410                 415     


Tyr His Gln Glu Gly Gly Pro Asp Gly Glu Pro Asp Val Pro Pro Gly 
            420                 425                 430         


Ala Ile Glu Gln Gly Pro Ala Asp Asp Pro Gly Glu Gly Pro Ser Thr 
        435                 440                 445             


Gly Pro Arg Gly Gln Gly Asp Gly Gly Arg Arg Lys Lys Gly Gly Trp 
    450                 455                 460                 


Phe Gly Lys His Arg Gly Gln Gly Gly Ser Asn Pro Lys Phe Glu Asn 
465                 470                 475                 480 


Ile Ala Glu Gly Leu Arg Ala Leu Leu Ala Arg Ser His Val Glu Arg 
                485                 490                 495     


Thr Thr Asp Glu Gly Thr Trp Val Ala Gly Val Phe Val Tyr Gly Gly 
            500                 505                 510         


Ser Lys Thr Ser Leu Tyr Asn Leu Arg Arg Gly Thr Ala Leu Ala Ile 
        515                 520                 525             


Pro Gln Cys Arg Leu Thr Pro Leu Ser Arg Leu Pro Phe Gly Met Ala 
    530                 535                 540                 


Pro Gly Pro Gly Pro Gln Pro Gly Pro Leu Arg Glu Ser Ile Val Cys 
545                 550                 555                 560 


Tyr Phe Met Val Phe Leu Gln Thr His Ile Phe Ala Glu Val Leu Lys 
                565                 570                 575     


Asp Ala Ile Lys Asp Leu Val Met Thr Lys Pro Ala Pro Thr Cys Asn 
            580                 585                 590         


Ile Arg Val Thr Val Cys Ser Phe Asp Asp Gly Val Asp Leu Pro Pro 
        595                 600                 605             


Trp Phe Pro Pro Met Val Glu Gly Ala Ala Ala Glu Gly Asp Asp Gly 
    610                 615                 620                 


Asp Asp Gly Asp Glu Gly Gly Asp Gly Asp Glu Gly Glu Glu Gly Gln 
625                 630                 635                 640 


Glu 
    


<210>  24
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ser Gly Tyr Ser Ser Asp Arg Asp Arg Gly Arg Asp Arg Gly Phe 
1               5                   10                  15      


Gly Ala Pro Arg Phe Gly Gly Ser Arg Ala Gly Pro Leu Ser Gly Lys 
            20                  25                  30          


Lys Phe Gly Asn Pro Gly Glu Lys Leu Val Lys Lys Lys Trp Asn Leu 
        35                  40                  45              


Asp Glu Leu Pro Lys Phe Glu Lys Asn Phe Tyr Gln Glu His Pro Asp 
    50                  55                  60                  


Leu Ala Arg Arg Thr Ala Gln Glu Val Glu Thr Tyr Arg Arg Ser Lys 
65                  70                  75                  80  


Glu Ile Thr Val Arg Gly His Asn Cys Pro Lys Pro Val Leu Asn Phe 
                85                  90                  95      


Tyr Glu Ala Asn Phe Pro Ala Asn Val Met Asp Val Ile Ala Arg Gln 
            100                 105                 110         


Asn Phe Thr Glu Pro Thr Ala Ile Gln Ala Gln Gly Trp Pro Val Ala 
        115                 120                 125             


Leu Ser Gly Leu Asp Met Val Gly Val Ala Gln Thr Gly Ser Gly Lys 
    130                 135                 140                 


Thr Leu Ser Tyr Leu Leu Pro Ala Ile Val His Ile Asn His Gln Pro 
145                 150                 155                 160 


Phe Leu Glu Arg Gly Asp Gly Pro Ile Cys Leu Val Leu Ala Pro Thr 
                165                 170                 175     


Arg Glu Leu Ala Gln Gln Val Gln Gln Val Ala Ala Glu Tyr Cys Arg 
            180                 185                 190         


Ala Cys Arg Leu Lys Ser Thr Cys Ile Tyr Gly Gly Ala Pro Lys Gly 
        195                 200                 205             


Pro Gln Ile Arg 
    210         


<210>  25
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Leu Leu Ala Val Leu Tyr Cys Leu Leu Trp Ser Phe Gln Thr Ser 
1               5                   10                  15      


Ala Gly His Phe Pro Arg Ala Cys Val Ser Ser Lys Asn Leu Met Glu 
            20                  25                  30          


Lys Glu Cys Cys Pro Pro Trp Ser Gly Asp Arg Ser Pro Cys Gly Gln 
        35                  40                  45              


Leu Ser Gly Arg Gly Ser Cys Gln Asn Ile Leu Leu Ser Asn Ala Pro 
    50                  55                  60                  


Leu Gly Pro Gln Phe Pro Phe Thr Gly Val Asp Asp Arg Glu Ser Trp 
65                  70                  75                  80  


Pro Ser Val Phe Tyr Asn Arg Thr Cys Gln Cys Ser Gly Asn Phe Met 
                85                  90                  95      


Gly Phe Asn Cys Gly Asn Cys Lys Phe Gly Phe Trp Gly Pro Asn Cys 
            100                 105                 110         


Thr Glu Arg Arg Leu Leu Val Arg Arg Asn Ile Phe Asp Leu Ser Ala 
        115                 120                 125             


Pro Glu Lys Asp Lys Phe Phe Ala Tyr Leu Thr Leu Ala Lys His Thr 
    130                 135                 140                 


Ile Ser Ser Asp Tyr Val Ile Pro Ile Gly Thr Tyr Gly Gln Met Lys 
145                 150                 155                 160 


Asn Gly Ser Thr Pro Met Phe Asn Asp Ile Asn Ile Tyr Asp Leu Phe 
                165                 170                 175     


Val Trp Met His Tyr Tyr Val Ser Met Asp Ala Leu Leu Gly Gly Ser 
            180                 185                 190         


Glu Ile Trp Arg Asp Ile Asp Phe Ala His Glu Ala Pro Ala Phe Leu 
        195                 200                 205             


Pro Trp His Arg Leu Phe Leu Leu Arg Trp Glu Gln Glu Ile Gln Lys 
    210                 215                 220                 


Leu Thr Gly Asp Glu Asn Phe Thr Ile Pro Tyr Trp Asp Trp Arg Asp 
225                 230                 235                 240 


Ala Glu Lys Cys Asp Ile Cys Thr Asp Glu Tyr Met Gly Gly Gln His 
                245                 250                 255     


Pro Thr Asn Pro Asn Leu Leu Ser Pro Ala Ser Phe Phe Ser Ser Trp 
            260                 265                 270         


Gln Ile Val Cys Ser Arg Leu Glu Glu Tyr Asn Ser His Gln Ser Leu 
        275                 280                 285             


Cys Asn Gly Thr Pro Glu Gly Pro Leu Arg Arg Asn Pro Gly Asn His 
    290                 295                 300                 


Asp Lys Ser Arg Thr Pro Arg Leu Pro Ser Ser Ala Asp Val Glu Phe 
305                 310                 315                 320 


Cys Leu Ser Leu Thr Gln Tyr Glu Ser Gly Ser Met Asp Lys Ala Ala 
                325                 330                 335     


Asn Phe Ser Phe Arg Asn Thr Leu Glu Gly Phe Ala Ser Pro Leu Thr 
            340                 345                 350         


Gly Ile Ala Asp Ala Ser Gln Ser Ser Met His Asn Ala Leu His Ile 
        355                 360                 365             


Tyr Met Asn Gly Thr Met Ser Gln Val Gln Gly Ser Ala Asn Asp Pro 
    370                 375                 380                 


Ile Phe Leu Leu His His Ala Phe Val Asp Ser Ile Phe Glu Gln Trp 
385                 390                 395                 400 


Leu Arg Arg His Arg Pro Leu Gln Glu Val Tyr Pro Glu Ala Asn Ala 
                405                 410                 415     


Pro Ile Gly His Asn Arg Glu Ser Tyr Met Val Pro Phe Ile Pro Leu 
            420                 425                 430         


Tyr Arg Asn Gly Asp Phe Phe Ile Ser Ser Lys Asp Leu Gly Tyr Asp 
        435                 440                 445             


Tyr Ser Tyr Leu Gln Asp Ser Asp Pro Asp Ser Phe Gln Asp Tyr Ile 
    450                 455                 460                 


Lys Ser Tyr Leu Glu Gln Ala Ser Arg Ile Trp Ser Trp Leu Leu Gly 
465                 470                 475                 480 


Ala Ala Met Val Gly Ala Val Leu Thr Ala Leu Leu Ala Gly Leu Val 
                485                 490                 495     


Ser Leu Leu Cys Arg His Lys Arg Lys Gln Leu Pro Glu Glu Lys Gln 
            500                 505                 510         


Pro Leu Leu Met Glu Lys Glu Asp Tyr His Ser Leu Tyr Gln Ser His 
        515                 520                 525             


Leu 
    


<210>  26
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Gly Lys Phe Leu Ala Thr Leu Ile Leu Phe Phe Gln Phe Cys Pro 
1               5                   10                  15      


Leu Ile Phe Gly Asp Tyr Ser Pro Ser Cys Cys Thr Leu Thr Ile Gly 
            20                  25                  30          


Val Ser Ser Tyr His Ser Lys Pro Cys Asn Pro Ala Gln Pro Val Cys 
        35                  40                  45              


Ser Trp Thr Leu Asp Leu Leu Ala Leu Ser Ala Asp Gln Ala Leu Gln 
    50                  55                  60                  


Pro Pro Cys Pro Asn Leu Val Ser Tyr Ser Ser Tyr His Ala Thr Tyr 
65                  70                  75                  80  


Ser Leu Tyr Leu Phe Pro His Trp Thr Lys Lys Pro Asn Arg Asn Gly 
                85                  90                  95      


Gly Gly Tyr Tyr Ser Ala Ser Tyr Ser Asp Pro Cys Ser Leu Lys Cys 
            100                 105                 110         


Pro Tyr Leu Gly Cys Gln Ser Trp Thr Cys Pro Tyr Thr Gly Ala Val 
        115                 120                 125             


Ser Ser Pro Tyr Trp Lys Phe Gln His Asp Val Asn Phe Thr Gln Glu 
    130                 135                 140                 


Val Ser Arg Leu Asn Ile Asn Leu His Phe Ser Lys Cys Gly Phe Pro 
145                 150                 155                 160 


Phe Ser Leu Leu Val Asp Ala Pro Gly Tyr Asp Pro Ile Trp Phe Leu 
                165                 170                 175     


Asn Thr Glu Pro Ser Gln Leu Pro Pro Thr Ala Pro Pro Leu Leu Pro 
            180                 185                 190         


His Ser Asn Leu Asp His Ile Leu Glu Pro Ser Ile Pro Trp Lys Ser 
        195                 200                 205             


Lys Leu Leu Thr Leu Val Gln Leu Thr Leu Gln Ser Thr Asn Tyr Thr 
    210                 215                 220                 


Cys Ile Val Cys Ile Asp Arg Ala Ser Leu Ser Thr Trp His Val Leu 
225                 230                 235                 240 


Tyr Ser Pro Asn Val Ser Val Pro Ser Ser Ser Ser Thr Pro Leu Leu 
                245                 250                 255     


Tyr Pro Ser Leu Ala Leu Pro Ala Pro His Leu Thr Leu Pro Phe Asn 
            260                 265                 270         


Trp Thr His Cys Phe Asp Pro Gln Ile Gln Ala Ile Val Ser Ser Pro 
        275                 280                 285             


Cys His Asn Ser Leu Ile Leu Pro Pro Phe Ser Leu Ser Pro Val Pro 
    290                 295                 300                 


Thr Leu Gly Ser Arg Ser Arg Arg Ala Val Pro Val Ala Val Trp Leu 
305                 310                 315                 320 


Val Ser Ala Leu Ala Met Gly Ala Gly Val Ala Gly Gly Ile Thr Gly 
                325                 330                 335     


Ser Met Ser Leu Ala Ser Gly Lys Ser Leu Leu His Glu Val Asp Lys 
            340                 345                 350         


Asp Ile Ser Gln Leu Thr Gln Ala Ile Val Lys Asn His Lys Asn Leu 
        355                 360                 365             


Leu Lys Ile Ala Gln Tyr Ala Ala Gln Asn Arg Arg Gly Leu Asp Leu 
    370                 375                 380                 


Leu Phe Trp Glu Gln Gly Gly Leu Cys Lys Ala Leu Gln Glu Gln Cys 
385                 390                 395                 400 


Arg Phe Pro Asn Ile Thr Asn Ser His Val Pro Ile Leu Gln Glu Arg 
                405                 410                 415     


Pro Pro Leu Glu Asn Arg Val Leu Thr Gly Trp Gly Leu Asn Trp Asp 
            420                 425                 430         


Leu Gly Leu Ser Gln Trp Ala Arg Glu Ala Leu Gln Thr Gly Ile Thr 
        435                 440                 445             


Leu Val Ala Leu Leu Leu Leu Val Ile Leu Ala Gly Pro Cys Ile Leu 
    450                 455                 460                 


Arg Gln Leu Arg His Leu Pro Ser Arg Val Arg Tyr Pro His Tyr Ser 
465                 470                 475                 480 


Leu Ile Lys Pro Glu Ser Ser Leu 
                485             


<210>  27
<211>  1019
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Cys Ile Cys Gly Thr Ala His Pro Val Leu Asp Glu Gly Pro Val 
1               5                   10                  15      


Arg Cys Arg Ala Gly Pro Arg Asp Leu Leu Glu Ala Arg Arg Pro Arg 
            20                  25                  30          


Ala His Glu Cys Leu Gly Glu Ala Leu Arg Val Met His Gln Ile Ile 
        35                  40                  45              


Ser Lys Tyr Pro Leu Leu Asn Thr Val Glu Thr Leu Thr Ala Ala Gly 
    50                  55                  60                  


Thr Leu Ile Ala Lys Val Lys Ala Phe His Tyr Glu Ser Asn Asn Asp 
65                  70                  75                  80  


Leu Glu Lys Gln Glu Phe Glu Lys Ala Leu Glu Thr Ile Ala Val Ala 
                85                  90                  95      


Phe Ser Ser Thr Val Ser Glu Phe Leu Met Gly Glu Val Asp Ser Ser 
            100                 105                 110         


Thr Leu Leu Ala Val Pro Pro Gly Asp Ser Ser Gln Ser Met Glu Ser 
        115                 120                 125             


Leu Tyr Gly Pro Gly Ser Glu Gly Thr Pro Pro Ser Leu Glu Asp Cys 
    130                 135                 140                 


Asp Ala Gly Cys Leu Pro Ala Glu Glu Val Asp Val Leu Leu Gln Arg 
145                 150                 155                 160 


Cys Glu Gly Gly Val Asp Ala Ala Leu Leu Tyr Ala Lys Asn Met Ala 
                165                 170                 175     


Lys Tyr Met Lys Asp Leu Ile Ser Tyr Leu Glu Lys Arg Thr Thr Leu 
            180                 185                 190         


Glu Met Glu Phe Ala Lys Gly Leu Gln Lys Ile Ala His Asn Cys Arg 
        195                 200                 205             


Gln Ser Val Met Gln Glu Pro His Met Pro Leu Leu Ser Ile Tyr Ser 
    210                 215                 220                 


Leu Ala Leu Glu Gln Asp Leu Glu Phe Gly His Ser Met Val Gln Ala 
225                 230                 235                 240 


Val Gly Thr Leu Gln Thr Gln Thr Phe Met Gln Pro Leu Thr Leu Arg 
                245                 250                 255     


Arg Leu Glu His Glu Lys Arg Arg Lys Glu Ile Lys Glu Ala Trp His 
            260                 265                 270         


Arg Ala Gln Arg Lys Leu Gln Glu Ala Glu Ser Asn Leu Arg Lys Ala 
        275                 280                 285             


Lys Gln Gly Tyr Val Gln Arg Cys Glu Asp His Asp Lys Ala Arg Phe 
    290                 295                 300                 


Leu Val Ala Lys Ala Glu Glu Glu Gln Ala Gly Ser Ala Pro Gly Ala 
305                 310                 315                 320 


Gly Ser Thr Ala Thr Lys Thr Leu Asp Lys Arg Arg Arg Leu Glu Glu 
                325                 330                 335     


Glu Ala Lys Asn Lys Ala Glu Glu Ala Met Ala Thr Tyr Arg Thr Cys 
            340                 345                 350         


Val Ala Asp Ala Lys Thr Gln Lys Gln Glu Leu Glu Asp Thr Lys Val 
        355                 360                 365             


Thr Ala Leu Arg Gln Ile Gln Glu Val Ile Arg Gln Ser Asp Gln Thr 
    370                 375                 380                 


Ile Lys Ser Ala Thr Ile Ser Tyr Tyr Gln Met Met His Met Gln Thr 
385                 390                 395                 400 


Ala Pro Leu Pro Val His Phe Gln Met Leu Cys Glu Ser Ser Lys Leu 
                405                 410                 415     


Tyr Asp Pro Gly Gln Gln Tyr Ala Ser His Val Arg Gln Leu Gln Arg 
            420                 425                 430         


Asp Gln Glu Pro Asp Val His Tyr Asp Phe Glu Pro His Val Ser Ala 
        435                 440                 445             


Asn Ala Trp Ser Pro Val Met Arg Ala Arg Lys Ser Ser Phe Asn Val 
    450                 455                 460                 


Ser Asp Val Ala Arg Pro Glu Ala Ala Gly Ser Pro Pro Glu Glu Gly 
465                 470                 475                 480 


Gly Cys Thr Glu Gly Thr Pro Ala Lys Asp His Arg Ala Gly Arg Gly 
                485                 490                 495     


His Gln Val His Lys Ser Trp Pro Leu Ser Ile Ser Asp Ser Asp Ser 
            500                 505                 510         


Gly Leu Asp Pro Gly Pro Gly Ala Gly Asp Phe Lys Lys Phe Glu Arg 
        515                 520                 525             


Thr Ser Ser Ser Gly Thr Met Ser Ser Thr Glu Glu Leu Val Asp Pro 
    530                 535                 540                 


Asp Gly Gly Ala Gly Ala Ser Ala Phe Glu Gln Ala Asp Leu Asn Gly 
545                 550                 555                 560 


Met Thr Pro Glu Leu Pro Val Ala Val Pro Ser Gly Pro Phe Arg His 
                565                 570                 575     


Glu Gly Leu Ser Lys Ala Ala Arg Thr His Arg Leu Arg Lys Leu Arg 
            580                 585                 590         


Thr Pro Ala Lys Cys Arg Glu Cys Asn Ser Tyr Val Tyr Phe Gln Gly 
        595                 600                 605             


Ala Glu Cys Glu Glu Cys Cys Leu Ala Cys His Lys Lys Cys Leu Glu 
    610                 615                 620                 


Thr Leu Ala Ile Gln Cys Gly His Lys Lys Leu Gln Gly Arg Leu Gln 
625                 630                 635                 640 


Leu Phe Gly Gln Asp Phe Ser His Ala Ala Arg Ser Ala Pro Asp Gly 
                645                 650                 655     


Val Pro Phe Ile Val Lys Lys Cys Val Cys Glu Ile Glu Arg Arg Ala 
            660                 665                 670         


Leu Arg Thr Lys Gly Ile Tyr Arg Val Asn Gly Val Lys Thr Arg Val 
        675                 680                 685             


Glu Lys Leu Cys Gln Ala Phe Glu Asn Gly Lys Glu Leu Val Glu Leu 
    690                 695                 700                 


Ser Gln Ala Ser Pro His Asp Ile Ser Asn Val Leu Lys Leu Tyr Leu 
705                 710                 715                 720 


Arg Gln Leu Pro Glu Pro Leu Ile Ser Phe Arg Leu Tyr His Glu Leu 
                725                 730                 735     


Val Gly Leu Ala Lys Asp Ser Leu Lys Ala Glu Ala Glu Ala Lys Ala 
            740                 745                 750         


Ala Ser Arg Gly Arg Gln Asp Gly Ser Glu Ser Glu Ala Val Ala Val 
        755                 760                 765             


Ala Leu Ala Gly Arg Leu Arg Glu Leu Leu Arg Asp Leu Pro Pro Glu 
    770                 775                 780                 


Asn Arg Ala Ser Leu Gln Tyr Leu Leu Arg His Leu Arg Arg Ile Val 
785                 790                 795                 800 


Glu Val Glu Gln Asp Asn Lys Met Thr Pro Gly Asn Leu Gly Ile Val 
                805                 810                 815     


Phe Gly Pro Thr Leu Leu Arg Pro Arg Pro Thr Glu Ala Thr Val Ser 
            820                 825                 830         


Leu Ser Ser Leu Val Asp Tyr Pro His Gln Ala Arg Val Ile Glu Thr 
        835                 840                 845             


Leu Ile Val His Tyr Gly Leu Val Phe Glu Glu Glu Pro Glu Glu Thr 
    850                 855                 860                 


Pro Gly Gly Gln Asp Glu Ser Ser Asn Gln Arg Ala Glu Val Val Val 
865                 870                 875                 880 


Gln Val Pro Tyr Leu Glu Ala Gly Glu Ala Val Val Tyr Pro Leu Gln 
                885                 890                 895     


Glu Ala Ala Ala Asp Gly Cys Arg Glu Ser Arg Val Val Ser Asn Asp 
            900                 905                 910         


Ser Asp Ser Asp Leu Glu Glu Ala Ser Glu Leu Leu Ser Ser Ser Glu 
        915                 920                 925             


Ala Ser Ala Leu Gly His Leu Ser Phe Leu Glu Gln Gln Gln Ser Glu 
    930                 935                 940                 


Ala Ser Leu Glu Val Ala Ser Gly Ser His Ser Gly Ser Glu Glu Gln 
945                 950                 955                 960 


Leu Glu Ala Thr Ala Arg Glu Asp Gly Asp Gly Asp Glu Asp Gly Pro 
                965                 970                 975     


Ala Gln Gln Leu Ser Gly Phe Asn Thr Asn Gln Ser Asn Asn Val Leu 
            980                 985                 990         


Gln Ala Pro Leu Pro Pro Met Arg  Leu Arg Gly Gly Arg  Met Thr Leu 
        995                 1000                 1005             


Gly Ser  Cys Arg Glu Arg Gln  Pro Glu Phe Val 
    1010                 1015                 


<210>  28
<211>  1018
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Glu Asp Glu Glu Gly Pro Glu Tyr Gly Lys Pro Asp Phe Val Leu 
1               5                   10                  15      


Leu Asp Gln Val Thr Met Glu Asp Phe Met Arg Asn Leu Gln Leu Arg 
            20                  25                  30          


Phe Glu Lys Gly Arg Ile Tyr Thr Tyr Ile Gly Glu Val Leu Val Ser 
        35                  40                  45              


Val Asn Pro Tyr Gln Glu Leu Pro Leu Tyr Gly Pro Glu Ala Ile Ala 
    50                  55                  60                  


Arg Tyr Gln Gly Arg Glu Leu Tyr Glu Arg Pro Pro His Leu Tyr Ala 
65                  70                  75                  80  


Val Ala Asn Ala Ala Tyr Lys Ala Met Lys His Arg Ser Arg Asp Thr 
                85                  90                  95      


Cys Ile Val Ile Ser Gly Glu Ser Gly Ala Gly Lys Thr Glu Ala Ser 
            100                 105                 110         


Lys His Ile Met Gln Tyr Ile Ala Ala Val Thr Asn Pro Ser Gln Arg 
        115                 120                 125             


Ala Glu Val Glu Arg Val Lys Asp Val Leu Leu Lys Ser Thr Cys Val 
    130                 135                 140                 


Leu Glu Ala Phe Gly Asn Ala Arg Thr Asn Arg Asn His Asn Ser Ser 
145                 150                 155                 160 


Arg Phe Gly Lys Tyr Met Asp Ile Asn Phe Asp Phe Lys Gly Asp Pro 
                165                 170                 175     


Ile Gly Gly His Ile His Ser Tyr Leu Leu Glu Lys Ser Arg Val Leu 
            180                 185                 190         


Lys Gln His Val Gly Glu Arg Asn Phe His Ala Phe Tyr Gln Leu Leu 
        195                 200                 205             


Arg Gly Ser Glu Asp Lys Gln Leu His Glu Leu His Leu Glu Arg Asn 
    210                 215                 220                 


Pro Ala Val Tyr Asn Phe Thr His Gln Gly Ala Gly Leu Asn Met Thr 
225                 230                 235                 240 


Val His Ser Ala Leu Asp Ser Asp Glu Gln Ser His Gln Ala Val Thr 
                245                 250                 255     


Glu Ala Met Arg Val Ile Gly Phe Ser Pro Glu Glu Val Glu Ser Val 
            260                 265                 270         


His Arg Ile Leu Ala Ala Ile Leu His Leu Gly Asn Ile Glu Phe Val 
        275                 280                 285             


Glu Thr Glu Glu Gly Gly Leu Gln Lys Glu Gly Leu Ala Val Ala Glu 
    290                 295                 300                 


Glu Ala Leu Val Asp His Val Ala Glu Leu Thr Ala Thr Pro Arg Asp 
305                 310                 315                 320 


Leu Val Leu Arg Ser Leu Leu Ala Arg Thr Val Ala Ser Gly Gly Arg 
                325                 330                 335     


Glu Leu Ile Glu Lys Gly His Thr Ala Ala Glu Ala Ser Tyr Ala Arg 
            340                 345                 350         


Asp Ala Cys Ala Lys Ala Val Tyr Gln Arg Leu Phe Glu Trp Val Val 
        355                 360                 365             


Asn Arg Ile Asn Ser Val Met Glu Pro Arg Gly Arg Asp Pro Arg Arg 
    370                 375                 380                 


Asp Gly Lys Asp Thr Val Ile Gly Val Leu Asp Ile Tyr Gly Phe Glu 
385                 390                 395                 400 


Val Phe Pro Val Asn Ser Phe Glu Gln Phe Cys Ile Asn Tyr Cys Asn 
                405                 410                 415     


Glu Lys Leu Gln Gln Leu Phe Ile Gln Leu Ile Leu Lys Gln Glu Gln 
            420                 425                 430         


Glu Glu Tyr Glu Arg Glu Gly Ile Thr Trp Gln Ser Val Glu Tyr Phe 
        435                 440                 445             


Asn Asn Ala Thr Ile Val Asp Leu Val Glu Arg Pro His Arg Gly Ile 
    450                 455                 460                 


Leu Ala Val Leu Asp Glu Ala Cys Ser Ser Ala Gly Thr Ile Thr Asp 
465                 470                 475                 480 


Arg Ile Phe Leu Gln Thr Leu Asp Met His His Arg His His Leu His 
                485                 490                 495     


Tyr Thr Ser Arg Gln Leu Cys Pro Thr Asp Lys Thr Met Glu Phe Gly 
            500                 505                 510         


Arg Asp Phe Arg Ile Lys His Tyr Ala Gly Asp Val Thr Tyr Ser Val 
        515                 520                 525             


Glu Gly Phe Ile Asp Lys Asn Arg Asp Phe Leu Phe Gln Asp Phe Lys 
    530                 535                 540                 


Arg Leu Leu Tyr Asn Ser Thr Asp Pro Thr Leu Arg Ala Met Trp Pro 
545                 550                 555                 560 


Asp Gly Gln Gln Asp Ile Thr Glu Val Thr Lys Arg Pro Leu Thr Ala 
                565                 570                 575     


Gly Thr Leu Phe Lys Asn Ser Met Val Ala Leu Val Glu Asn Leu Ala 
            580                 585                 590         


Ser Lys Glu Pro Phe Tyr Val Arg Cys Ile Lys Pro Asn Glu Asp Lys 
        595                 600                 605             


Val Ala Gly Lys Leu Asp Glu Asn His Cys Arg His Gln Val Ala Tyr 
    610                 615                 620                 


Leu Gly Leu Leu Glu Asn Val Arg Val Arg Arg Ala Gly Phe Ala Ser 
625                 630                 635                 640 


Arg Gln Pro Tyr Ser Arg Phe Leu Leu Arg Tyr Lys Met Thr Cys Glu 
                645                 650                 655     


Tyr Thr Trp Pro Asn His Leu Leu Gly Ser Asp Lys Ala Ala Val Ser 
            660                 665                 670         


Ala Leu Leu Glu Gln His Gly Leu Gln Gly Asp Val Ala Phe Gly His 
        675                 680                 685             


Ser Lys Leu Phe Ile Arg Ser Pro Arg Thr Leu Val Thr Leu Glu Gln 
    690                 695                 700                 


Ser Arg Ala Arg Leu Ile Pro Ile Ile Val Leu Leu Leu Gln Lys Ala 
705                 710                 715                 720 


Trp Arg Gly Thr Leu Ala Arg Trp Arg Cys Arg Arg Leu Arg Ala Ile 
                725                 730                 735     


Tyr Thr Ile Met Arg Trp Phe Arg Arg His Lys Val Arg Ala His Leu 
            740                 745                 750         


Ala Glu Leu Gln Arg Arg Phe Gln Ala Ala Arg Gln Pro Pro Leu Tyr 
        755                 760                 765             


Gly Arg Asp Leu Val Trp Pro Leu Pro Pro Ala Val Leu Gln Pro Phe 
    770                 775                 780                 


Gln Asp Thr Cys His Ala Leu Phe Cys Arg Trp Arg Ala Arg Gln Leu 
785                 790                 795                 800 


Val Lys Asn Ile Pro Pro Ser Asp Met Pro Gln Ile Lys Ala Lys Val 
                805                 810                 815     


Ala Ala Met Gly Ala Leu Gln Gly Leu Arg Gln Asp Trp Gly Cys Arg 
            820                 825                 830         


Arg Ala Trp Ala Arg Asp Tyr Leu Ser Ser Ala Thr Asp Asn Pro Thr 
        835                 840                 845             


Ala Ser Ser Leu Phe Ala Gln Arg Leu Lys Thr Leu Gln Asp Lys Asp 
    850                 855                 860                 


Gly Phe Gly Ala Val Leu Phe Ser Ser His Val Arg Lys Val Asn Arg 
865                 870                 875                 880 


Phe His Lys Ile Arg Asn Arg Ala Leu Leu Leu Thr Asp Gln His Leu 
                885                 890                 895     


Tyr Lys Leu Asp Pro Asp Arg Gln Tyr Arg Val Met Arg Ala Val Pro 
            900                 905                 910         


Leu Glu Ala Val Thr Gly Leu Ser Val Thr Ser Gly Gly Asp Gln Leu 
        915                 920                 925             


Val Val Leu His Ala Arg Gly Gln Asp Asp Leu Val Val Cys Leu His 
    930                 935                 940                 


Arg Ser Arg Pro Pro Leu Asp Asn Arg Val Gly Glu Leu Val Gly Val 
945                 950                 955                 960 


Leu Ala Ala His Cys Gln Gly Glu Gly Arg Thr Leu Glu Val Arg Val 
                965                 970                 975     


Ser Asp Cys Ile Pro Leu Ser His Arg Gly Val Arg Arg Leu Ile Ser 
            980                 985                 990         


Val Glu Pro Arg Pro Glu Gln Pro  Glu Pro Asp Phe Arg  Cys Ala Arg 
        995                 1000                 1005             


Gly Ser  Phe Thr Leu Leu Trp  Pro Ser Arg 
    1010                 1015             


<210>  29
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu 
1               5                   10                  15      


Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp 
            20                  25                  30          


Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Ala 
        35                  40                  45              


Asp Asn Asn Thr Lys Ala Asn Val Thr Lys Pro Lys Arg Cys Ser Gly 
    50                  55                  60                  


Ser Ile Cys Tyr Gly Thr Ile Ala Val Ile Val Phe Phe Leu Ile Gly 
65                  70                  75                  80  


Phe Met Ile Gly Tyr Leu Gly Tyr Cys Lys Gly Val Glu Pro Lys Thr 
                85                  90                  95      


Glu Cys Glu Arg Leu Ala Gly Thr Glu Ser Pro Val Arg Glu Glu Pro 
            100                 105                 110         


Gly Glu Asp Phe Pro Ala Ala Arg Arg Leu Tyr Trp Asp Asp Leu Lys 
        115                 120                 125             


Arg Lys Leu Ser Glu Lys Leu Asp Ser Thr Asp Phe Thr Gly Thr Ile 
    130                 135                 140                 


Lys Leu Leu Asn Glu Asn Ser Tyr Val Pro Arg Glu Ala Gly Ser Gln 
145                 150                 155                 160 


Lys Asp Glu Asn Leu Ala Leu Tyr Val Glu Asn Gln Phe Arg Glu Phe 
                165                 170                 175     


Lys Leu Ser Lys Val Trp Arg Asp Gln His Phe Val Lys Ile Gln Val 
            180                 185                 190         


Lys Asp Ser Ala Gln Asn Ser Val Ile Ile Val Asp Lys Asn Gly Arg 
        195                 200                 205             


Leu Val Tyr Leu Val Glu Asn Pro Gly Gly Tyr Val Ala Tyr Ser Lys 
    210                 215                 220                 


Ala Ala Thr Val Thr Gly Lys Leu Val His Ala Asn Phe Gly Thr Lys 
225                 230                 235                 240 


Lys Asp Phe Glu Asp Leu Tyr Thr Pro Val Asn Gly Ser Ile Val Ile 
                245                 250                 255     


Val Arg Ala Gly Lys Ile Thr Phe Ala Glu Lys Val Ala Asn Ala Glu 
            260                 265                 270         


Ser Leu Asn Ala Ile Gly Val Leu Ile Tyr Met Asp Gln Thr Lys Phe 
        275                 280                 285             


Pro Ile Val Asn Ala Glu Leu Ser Phe Phe Gly His Ala His Leu Gly 
    290                 295                 300                 


Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn His Thr Gln 
305                 310                 315                 320 


Phe Pro Pro Ser Arg Ser Ser Gly Leu Pro Asn Ile Pro Val Gln Thr 
                325                 330                 335     


Ile Ser Arg Ala Ala Ala Glu Lys Leu Phe Gly Asn Met Glu Gly Asp 
            340                 345                 350         


Cys Pro Ser Asp Trp Lys Thr Asp Ser Thr Cys Arg Met Val Thr Ser 
        355                 360                 365             


Glu Ser Lys Asn Val Lys Leu Thr Val Ser Asn Val Leu Lys Glu Ile 
    370                 375                 380                 


Lys Ile Leu Asn Ile Phe Gly Val Ile Lys Gly Phe Val Glu Pro Asp 
385                 390                 395                 400 


His Tyr Val Val Val Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala 
                405                 410                 415     


Ala Lys Ser Gly Val Gly Thr Ala Leu Leu Leu Lys Leu Ala Gln Met 
            420                 425                 430         


Phe Ser Asp Met Val Leu Lys Asp Gly Phe Gln Pro Ser Arg Ser Ile 
        435                 440                 445             


Ile Phe Ala Ser Trp Ser Ala Gly Asp Phe Gly Ser Val Gly Ala Thr 
    450                 455                 460                 


Glu Trp Leu Glu Gly Tyr Leu Ser Ser Leu His Leu Lys Ala Phe Thr 
465                 470                 475                 480 


Tyr Ile Asn Leu Asp Lys Ala Val Leu Gly Thr Ser Asn Phe Lys Val 
                485                 490                 495     


Ser Ala Ser Pro Leu Leu Tyr Thr Leu Ile Glu Lys Thr Met Gln Asn 
            500                 505                 510         


Val Lys His Pro Val Thr Gly Gln Phe Leu Tyr Gln Asp Ser Asn Trp 
        515                 520                 525             


Ala Ser Lys Val Glu Lys Leu Thr Leu Asp Asn Ala Ala Phe Pro Phe 
    530                 535                 540                 


Leu Ala Tyr Ser Gly Ile Pro Ala Val Ser Phe Cys Phe Cys Glu Asp 
545                 550                 555                 560 


Thr Asp Tyr Pro Tyr Leu Gly Thr Thr Met Asp Thr Tyr Lys Glu Leu 
                565                 570                 575     


Ile Glu Arg Ile Pro Glu Leu Asn Lys Val Ala Arg Ala Ala Ala Glu 
            580                 585                 590         


Val Ala Gly Gln Phe Val Ile Lys Leu Thr His Asp Val Glu Leu Asn 
        595                 600                 605             


Leu Asp Tyr Glu Arg Tyr Asn Ser Gln Leu Leu Ser Phe Val Arg Asp 
    610                 615                 620                 


Leu Asn Gln Tyr Arg Ala Asp Ile Lys Glu Met Gly Leu Ser Leu Gln 
625                 630                 635                 640 


Trp Leu Tyr Ser Ala Arg Gly Asp Phe Phe Arg Ala Thr Ser Arg Leu 
                645                 650                 655     


Thr Thr Asp Phe Gly Asn Ala Glu Lys Thr Asp Arg Phe Val Met Lys 
            660                 665                 670         


Lys Leu Asn Asp Arg Val Met Arg Val Glu Tyr His Phe Leu Ser Pro 
        675                 680                 685             


Tyr Val Ser Pro Lys Glu Ser Pro Phe Arg His Val Phe Trp Gly Ser 
    690                 695                 700                 


Gly Ser His Thr Leu Pro Ala Leu Leu Glu Asn Leu Lys Leu Arg Lys 
705                 710                 715                 720 


Gln Asn Asn Gly Ala Phe Asn Glu Thr Leu Phe Arg Asn Gln Leu Ala 
                725                 730                 735     


Leu Ala Thr Trp Thr Ile Gln Gly Ala Ala Asn Ala Leu Ser Gly Asp 
            740                 745                 750         


Val Trp Asp Ile Asp Asn Glu Phe 
        755                 760 


<210>  30
<211>  510
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Asp Gly Phe Tyr Asp Gln Gln Val Pro Phe Met Val Pro Gly Lys 
1               5                   10                  15      


Ser Arg Ser Glu Glu Cys Arg Gly Arg Pro Val Ile Asp Arg Lys Arg 
            20                  25                  30          


Lys Phe Leu Asp Thr Asp Leu Ala His Asp Ser Glu Glu Leu Phe Gln 
        35                  40                  45              


Asp Leu Ser Gln Leu Gln Glu Ala Trp Leu Ala Glu Ala Gln Val Pro 
    50                  55                  60                  


Asp Asp Glu Gln Phe Val Pro Asp Phe Gln Ser Asp Asn Leu Val Leu 
65                  70                  75                  80  


His Ala Pro Pro Pro Thr Lys Ile Lys Arg Glu Leu His Ser Pro Ser 
                85                  90                  95      


Ser Glu Leu Ser Ser Cys Ser His Glu Gln Ala Leu Gly Ala Asn Tyr 
            100                 105                 110         


Gly Glu Lys Cys Leu Tyr Asn Tyr Cys Ala Tyr Asp Arg Lys Pro Pro 
        115                 120                 125             


Ser Gly Phe Lys Pro Leu Thr Pro Pro Thr Thr Pro Leu Ser Pro Thr 
    130                 135                 140                 


His Gln Asn Pro Leu Phe Pro Pro Pro Gln Ala Thr Leu Pro Thr Ser 
145                 150                 155                 160 


Gly His Ala Pro Ala Ala Gly Pro Val Gln Gly Val Gly Pro Ala Pro 
                165                 170                 175     


Ala Pro His Ser Leu Pro Glu Pro Gly Pro Gln Gln Gln Thr Phe Ala 
            180                 185                 190         


Val Pro Arg Pro Pro His Gln Pro Leu Gln Met Pro Lys Met Met Pro 
        195                 200                 205             


Glu Asn Gln Tyr Pro Ser Glu Gln Arg Phe Gln Arg Gln Leu Ser Glu 
    210                 215                 220                 


Pro Cys His Pro Phe Pro Pro Gln Pro Gly Val Pro Gly Asp Asn Arg 
225                 230                 235                 240 


Pro Ser Tyr His Arg Gln Met Ser Glu Pro Ile Val Pro Ala Ala Pro 
                245                 250                 255     


Pro Pro Pro Gln Gly Phe Lys Gln Glu Tyr His Asp Pro Leu Tyr Glu 
            260                 265                 270         


His Gly Val Pro Gly Met Pro Gly Pro Pro Ala His Gly Phe Gln Ser 
        275                 280                 285             


Pro Met Gly Ile Lys Gln Glu Pro Arg Asp Tyr Cys Val Asp Ser Glu 
    290                 295                 300                 


Val Pro Asn Cys Gln Ser Ser Tyr Met Arg Gly Gly Tyr Phe Ser Ser 
305                 310                 315                 320 


Ser His Glu Gly Phe Ser Tyr Glu Lys Asp Pro Arg Leu Tyr Phe Asp 
                325                 330                 335     


Asp Thr Cys Val Val Pro Glu Arg Leu Glu Gly Lys Val Lys Gln Glu 
            340                 345                 350         


Pro Thr Met Tyr Arg Glu Gly Pro Pro Tyr Gln Arg Arg Gly Ser Leu 
        355                 360                 365             


Gln Leu Trp Gln Phe Leu Val Thr Leu Leu Asp Asp Pro Ala Asn Ala 
    370                 375                 380                 


His Phe Ile Ala Trp Thr Gly Arg Gly Met Glu Phe Lys Leu Ile Glu 
385                 390                 395                 400 


Pro Glu Glu Val Ala Arg Arg Trp Gly Ile Gln Lys Asn Arg Pro Ala 
                405                 410                 415     


Met Asn Tyr Asp Lys Leu Ser Arg Ser Leu Arg Tyr Tyr Tyr Glu Lys 
            420                 425                 430         


Gly Ile Met Gln Lys Val Ala Gly Glu Arg Tyr Val Tyr Lys Phe Val 
        435                 440                 445             


Cys Asp Pro Asp Ala Leu Phe Ser Met Ala Phe Pro Asp Asn Gln Arg 
    450                 455                 460                 


Pro Phe Leu Lys Ala Glu Ser Glu Cys His Leu Ser Glu Glu Asp Thr 
465                 470                 475                 480 


Leu Pro Leu Thr His Phe Glu Asp Ser Pro Ala Tyr Leu Leu Asp Met 
                485                 490                 495     


Asp Arg Cys Ser Ser Leu Pro Tyr Ala Glu Gly Phe Ala Tyr 
            500                 505                 510 


<210>  31
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Cys Asn Thr Asn Met Ser Val Pro Thr Asp Gly Ala Val Thr Thr 
1               5                   10                  15      


Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr Leu Val Arg Pro Lys Pro 
            20                  25                  30          


Leu Leu Leu Lys Leu Leu Lys Ser Val Gly Ala Gln Lys Asp Thr Tyr 
        35                  40                  45              


Thr Met Lys Glu Val Leu Phe Tyr Leu Gly Gln Tyr Ile Met Thr Lys 
    50                  55                  60                  


Arg Leu Tyr Asp Glu Lys Gln Gln His Ile Val Tyr Cys Ser Asn Asp 
65                  70                  75                  80  


Leu Leu Gly Asp Leu Phe Gly Val Pro Ser Phe Ser Val Lys Glu His 
                85                  90                  95      


Arg Lys Ile Tyr Thr Met Ile Tyr Arg Asn Leu Val Val Val Asn Gln 
            100                 105                 110         


Gln Glu Ser Ser Asp Ser Gly Thr Ser Val Ser Glu Asn Arg Cys His 
        115                 120                 125             


Leu Glu Gly Gly Ser Asp Gln Lys Asp Leu Val Gln Glu Leu Gln Glu 
    130                 135                 140                 


Glu Lys Pro Ser Ser Ser His Leu Val Ser Arg Pro Ser Thr Ser Ser 
145                 150                 155                 160 


Arg Arg Arg Ala Ile Ser Glu Thr Glu Glu Asn Ser Asp Glu Leu Ser 
                165                 170                 175     


Gly Glu Arg Gln Arg Lys Arg His Lys Ser Asp Ser Ile Ser Leu Ser 
            180                 185                 190         


Phe Asp Glu Ser Leu Ala Leu Cys Val Ile Arg Glu Ile Cys Cys Glu 
        195                 200                 205             


Arg Ser Ser Ser Ser Glu Ser Thr Gly Thr Pro Ser Asn Pro Asp Leu 
    210                 215                 220                 


Asp Ala Gly Val Ser Glu His Ser Gly Asp Trp Leu Asp Gln Asp Ser 
225                 230                 235                 240 


Val Ser Asp Gln Phe Ser Val Glu Phe Glu Val Glu Ser Leu Asp Ser 
                245                 250                 255     


Glu Asp Tyr Ser Leu Ser Glu Glu Gly Gln Glu Leu Ser Asp Glu Asp 
            260                 265                 270         


Asp Glu Val Tyr Gln Val Thr Val Tyr Gln Ala Gly Glu Ser Asp Thr 
        275                 280                 285             


Asp Ser Phe Glu Glu Asp Pro Glu Ile Ser Leu Ala Asp Tyr Trp Lys 
    290                 295                 300                 


Cys Thr Ser Cys Asn Glu Met Asn Pro Pro Leu Pro Ser His Cys Asn 
305                 310                 315                 320 


Arg Cys Trp Ala Leu Arg Glu Asn Trp Leu Pro Glu Asp Lys Gly Lys 
                325                 330                 335     


Asp Lys Gly Glu Ile Ser Glu Lys Ala Lys Leu Glu Asn Ser Thr Gln 
            340                 345                 350         


Ala Glu Glu Gly Phe Asp Val Pro Asp Cys Lys Lys Thr Ile Val Asn 
        355                 360                 365             


Asp Ser Arg Glu Ser Cys Val Glu Glu Asn Asp Asp Lys Ile Thr Gln 
    370                 375                 380                 


Ala Ser Gln Ser Gln Glu Ser Glu Asp Tyr Ser Gln Pro Ser Thr Ser 
385                 390                 395                 400 


Ser Ser Ile Ile Tyr Ser Ser Gln Glu Asp Val Lys Glu Phe Glu Arg 
                405                 410                 415     


Glu Glu Thr Gln Asp Lys Glu Glu Ser Val Glu Ser Ser Leu Pro Leu 
            420                 425                 430         


Asn Ala Ile Glu Pro Cys Val Ile Cys Gln Gly Arg Pro Lys Asn Gly 
        435                 440                 445             


Cys Ile Val His Gly Lys Thr Gly His Leu Met Ala Cys Phe Thr Cys 
    450                 455                 460                 


Ala Lys Lys Leu Lys Lys Arg Asn Lys Pro Cys Pro Val Cys Arg Gln 
465                 470                 475                 480 


Pro Ile Gln Met Ile Val Leu Thr Tyr Phe Pro 
                485                 490     


<210>  32
<211>  437
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Thr Gln Phe Leu Pro Pro Asn Leu Leu Ala Leu Phe Ala Pro Arg 
1               5                   10                  15      


Asp Pro Ile Pro Tyr Leu Pro Pro Leu Glu Lys Leu Pro His Glu Lys 
            20                  25                  30          


His His Asn Gln Pro Tyr Cys Gly Ile Ala Pro Tyr Ile Arg Glu Phe 
        35                  40                  45              


Glu Asp Pro Arg Asp Ala Pro Pro Pro Thr Arg Ala Glu Thr Arg Glu 
    50                  55                  60                  


Glu Arg Met Glu Arg Lys Arg Arg Glu Lys Ile Glu Arg Arg Gln Gln 
65                  70                  75                  80  


Glu Val Glu Thr Glu Leu Lys Met Trp Asp Pro His Asn Asp Pro Asn 
                85                  90                  95      


Ala Gln Gly Asp Ala Phe Lys Thr Leu Phe Val Ala Arg Val Asn Tyr 
            100                 105                 110         


Asp Thr Thr Glu Ser Lys Leu Arg Arg Glu Phe Glu Val Tyr Gly Pro 
        115                 120                 125             


Ile Lys Arg Ile His Met Val Tyr Ser Lys Arg Ser Gly Lys Pro Arg 
    130                 135                 140                 


Gly Tyr Ala Phe Ile Glu Tyr Glu His Glu Arg Asp Met His Ser Ala 
145                 150                 155                 160 


Tyr Lys His Ala Asp Gly Lys Lys Ile Asp Gly Arg Arg Val Leu Val 
                165                 170                 175     


Asp Val Glu Arg Gly Arg Thr Val Lys Gly Trp Arg Pro Arg Arg Leu 
            180                 185                 190         


Gly Gly Gly Leu Gly Gly Thr Arg Arg Gly Gly Ala Asp Val Asn Ile 
        195                 200                 205             


Arg His Ser Gly Arg Asp Asp Thr Ser Arg Tyr Asp Glu Arg Pro Gly 
    210                 215                 220                 


Pro Ser Pro Leu Pro His Arg Asp Arg Asp Arg Asp Arg Glu Arg Glu 
225                 230                 235                 240 


Arg Arg Glu Arg Ser Arg Glu Arg Asp Lys Glu Arg Glu Arg Arg Arg 
                245                 250                 255     


Ser Arg Ser Arg Asp Arg Arg Arg Arg Ser Arg Ser Arg Asp Lys Glu 
            260                 265                 270         


Glu Arg Arg Arg Ser Arg Glu Arg Ser Lys Asp Lys Asp Arg Asp Arg 
        275                 280                 285             


Lys Arg Arg Ser Ser Arg Ser Arg Glu Arg Ala Arg Arg Glu Arg Glu 
    290                 295                 300                 


Arg Lys Glu Glu Leu Arg Gly Gly Gly Gly Asp Met Ala Glu Pro Ser 
305                 310                 315                 320 


Glu Ala Gly Asp Ala Pro Pro Asp Asp Gly Pro Pro Gly Glu Leu Gly 
                325                 330                 335     


Pro Asp Gly Pro Asp Gly Pro Glu Glu Lys Gly Arg Asp Arg Asp Arg 
            340                 345                 350         


Glu Arg Arg Arg Ser His Arg Ser Glu Arg Glu Arg Arg Arg Asp Arg 
        355                 360                 365             


Asp Arg Asp Arg Asp Arg Asp Arg Glu His Lys Arg Gly Glu Arg Gly 
    370                 375                 380                 


Ser Glu Arg Gly Arg Asp Glu Ala Arg Gly Gly Gly Gly Gly Gln Asp 
385                 390                 395                 400 


Asn Gly Leu Glu Gly Leu Gly Asn Asp Ser Arg Asp Met Tyr Met Glu 
                405                 410                 415     


Ser Glu Gly Gly Asp Gly Tyr Leu Ala Pro Glu Asn Gly Tyr Leu Met 
            420                 425                 430         


Glu Ala Ala Pro Glu 
        435         


<210>  33
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Glu Leu Ala Thr Arg Tyr Gln Ile Pro Lys Glu Val Ala Asp Ile 
1               5                   10                  15      


Phe Asn Ala Pro Ser Asp Asp Glu Glu Phe Val Gly Phe Arg Asp Asp 
            20                  25                  30          


Val Pro Met Glu Thr Leu Ser Ser Glu Glu Ser Cys Asp Ser Phe Asp 
        35                  40                  45              


Ser Leu Glu Ser Gly Lys Gln Gln Asp Val Arg Phe His Ser Lys Tyr 
    50                  55                  60                  


Phe Thr Glu Glu Leu Arg Arg Ile Phe Ile Glu Asp Thr Asp Ser Glu 
65                  70                  75                  80  


Thr Glu Asp Phe Ala Gly Phe Thr Gln Ser Asp Leu Asn Gly Lys Thr 
                85                  90                  95      


Asn Pro Glu Val Met Val Val Glu Ser Asp Leu Ser Asp Asp Gly Lys 
            100                 105                 110         


Ala Ser Leu Val Ser Glu Glu Glu Glu Asp Glu Glu Glu Asp Lys Ala 
        115                 120                 125             


Thr Pro Arg Arg Ser Arg Ser Arg Arg Ser Ser Ile Gly Leu Arg Val 
    130                 135                 140                 


Ala Phe Gln Phe Pro Thr Lys Lys Leu Ala Asn Lys Pro Asp Lys Asn 
145                 150                 155                 160 


Ser Ser Ser Glu Gln Leu Phe Ser Ser Ala Arg Leu Gln Asn Glu Lys 
                165                 170                 175     


Lys Thr Ile Leu Glu Arg Lys Lys Asp Cys Arg Gln Val Ile Gln Arg 
            180                 185                 190         


Glu Asp Ser Thr Ser Glu Ser Glu Asp Asp Ser Arg Asp Glu Ser Gln 
        195                 200                 205             


Glu Ser Ser Asp Ala Leu Leu Lys Arg Thr Met Asn Ile Lys Glu Asn 
    210                 215                 220                 


Lys Ala Met Leu Ala Gln Leu Leu Ala Glu Leu Asn Ser Met Pro Asp 
225                 230                 235                 240 


Phe Phe Pro Val Arg Thr Pro Thr Ser Ala Ser Arg Lys Lys Thr Val 
                245                 250                 255     


Arg Arg Ala Phe Ser Glu Gly Gln Ile Thr Arg Arg Met Asn Pro Thr 
            260                 265                 270         


Arg Ser Ala Arg Pro Pro Glu Lys Phe Ala Leu Glu Asn Phe Thr Val 
        275                 280                 285             


Ser Ala Ala Lys Phe Ala Glu Glu Phe Tyr Ser Phe Arg Arg Arg Lys 
    290                 295                 300                 


Thr Ile Gly Gly Lys Cys Arg Glu Tyr Arg Arg Arg His Arg Ile Ser 
305                 310                 315                 320 


Ser Phe Arg Pro Val Glu Asp Ile Thr Glu Glu Asp Leu Glu Asn Val 
                325                 330                 335     


Ala Ile Thr Val Arg Asp Lys Ile Tyr Asp Lys Val Leu Gly Asn Thr 
            340                 345                 350         


Cys His Gln Cys Arg Gln Lys Thr Ile Asp Thr Lys Thr Val Cys Arg 
        355                 360                 365             


Asn Gln Gly Cys Cys Gly Val Arg Gly Gln Phe Cys Gly Pro Cys Leu 
    370                 375                 380                 


Arg Asn Arg Tyr Gly Glu Asp Val Arg Ser Ala Leu Leu Asp Pro Asp 
385                 390                 395                 400 


Trp Val Cys Pro Pro Cys Arg Gly Ile Cys Asn Cys Ser Tyr Cys Arg 
                405                 410                 415     


Lys Arg Asp Gly Arg Cys Ala Thr Gly Ile Leu Ile His Leu Ala Lys 
            420                 425                 430         


Phe Tyr Gly Tyr Asp Asn Val Lys Glu Tyr Leu Glu Ser Leu Gln Lys 
        435                 440                 445             


Glu Leu Val Glu Asp Asn 
    450                 


<210>  34
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Leu Leu Ser Lys Ile Asn Ser Leu Ala His Leu Arg Ala Ala Pro 
1               5                   10                  15      


Cys Asn Asp Leu His Ala Thr Lys Leu Ala Pro Gly Lys Glu Lys Glu 
            20                  25                  30          


Pro Leu Glu Ser Gln Tyr Gln Val Gly Pro Leu Leu Gly Ser Gly Gly 
        35                  40                  45              


Phe Gly Ser Val Tyr Ser Gly Ile Arg Val Ser Asp Asn Leu Pro Val 
    50                  55                  60                  


Ala Ile Lys His Val Glu Lys Asp Arg Ile Ser Asp Trp Gly Glu Leu 
65                  70                  75                  80  


Pro Asn Gly Thr Arg Val Pro Met Glu Val Val Leu Leu Lys Lys Val 
                85                  90                  95      


Ser Ser Gly Phe Ser Gly Val Ile Arg Leu Leu Asp Trp Phe Glu Arg 
            100                 105                 110         


Pro Asp Ser Phe Val Leu Ile Leu Glu Arg Pro Glu Pro Val Gln Asp 
        115                 120                 125             


Leu Phe Asp Phe Ile Thr Glu Arg Gly Ala Leu Gln Glu Glu Leu Ala 
    130                 135                 140                 


Arg Ser Phe Phe Trp Gln Val Leu Glu Ala Val Arg His Cys His Asn 
145                 150                 155                 160 


Cys Gly Val Leu His Arg Asp Ile Lys Asp Glu Asn Ile Leu Ile Asp 
                165                 170                 175     


Leu Asn Arg Gly Glu Leu Lys Leu Ile Asp Phe Gly Ser Gly Ala Leu 
            180                 185                 190         


Leu Lys Asp Thr Val Tyr Thr Asp Phe Asp Gly Thr Arg Val Tyr Ser 
        195                 200                 205             


Pro Pro Glu Trp Ile Arg Tyr His Arg Tyr His Gly Arg Ser Ala Ala 
    210                 215                 220                 


Val Trp Ser Leu Gly Ile Leu Leu Tyr Asp Met Val Cys Gly Asp Ile 
225                 230                 235                 240 


Pro Phe Glu His Asp Glu Glu Ile Ile Arg Gly Gln Val Phe Phe Arg 
                245                 250                 255     


Gln Arg Val Ser Ser Glu Cys Gln His Leu Ile Arg Trp Cys Leu Ala 
            260                 265                 270         


Leu Arg Pro Ser Asp Arg Pro Thr Phe Glu Glu Ile Gln Asn His Pro 
        275                 280                 285             


Trp Met Gln Asp Val Leu Leu Pro Gln Glu Thr Ala Glu Ile His Leu 
    290                 295                 300                 


His Ser Leu Ser Pro Gly Pro Ser Lys 
305                 310             


<210>  35
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Phe Gln Ala Ser Met Arg Ser Pro Asn Met Glu Pro Phe Lys Gln 
1               5                   10                  15      


Gln Lys Val Glu Asp Phe Tyr Asp Ile Gly Glu Glu Leu Gly Ser Gly 
            20                  25                  30          


Gln Phe Ala Ile Val Lys Lys Cys Arg Glu Lys Ser Thr Gly Leu Glu 
        35                  40                  45              


Tyr Ala Ala Lys Phe Ile Lys Lys Arg Gln Ser Arg Ala Ser Arg Arg 
    50                  55                  60                  


Gly Val Ser Arg Glu Glu Ile Glu Arg Glu Val Ser Ile Leu Arg Gln 
65                  70                  75                  80  


Val Leu His His Asn Val Ile Thr Leu His Asp Val Tyr Glu Asn Arg 
                85                  90                  95      


Thr Asp Val Val Leu Ile Leu Glu Leu Val Ser Gly Gly Glu Leu Phe 
            100                 105                 110         


Asp Phe Leu Ala Gln Lys Glu Ser Leu Ser Glu Glu Glu Ala Thr Ser 
        115                 120                 125             


Phe Ile Lys Gln Ile Leu Asp Gly Val Asn Tyr Leu His Thr Lys Lys 
    130                 135                 140                 


Ile Ala His Phe Asp Leu Lys Pro Glu Asn Ile Met Leu Leu Asp Lys 
145                 150                 155                 160 


Asn Ile Pro Ile Pro His Ile Lys Leu Ile Asp Phe Gly Leu Ala His 
                165                 170                 175     


Glu Ile Glu Asp Gly Val Glu Phe Lys Asn Ile Phe Gly Thr Pro Glu 
            180                 185                 190         


Phe Val Ala Pro Glu Ile Val Asn Tyr Glu Pro Leu Gly Leu Glu Ala 
        195                 200                 205             


Asp Met Trp Ser Ile Gly Val Ile Thr Tyr Ile Leu Leu Ser Gly Ala 
    210                 215                 220                 


Ser Pro Phe Leu Gly Asp Thr Lys Gln Glu Thr Leu Ala Asn Ile Thr 
225                 230                 235                 240 


Ala Val Ser Tyr Asp Phe Asp Glu Glu Phe Phe Ser Gln Thr Ser Glu 
                245                 250                 255     


Leu Ala Lys Asp Phe Ile Arg Lys Leu Leu Val Lys Glu Thr Arg Lys 
            260                 265                 270         


Arg Leu Thr Ile Gln Glu Ala Leu Arg His Pro Trp Ile Thr Pro Val 
        275                 280                 285             


Asp Asn Gln Gln Ala Met Val Arg Arg Glu Ser Val Val Asn Leu Glu 
    290                 295                 300                 


Asn Phe Arg Lys Gln Tyr Val Arg Arg Arg Trp Lys Leu Ser Phe Ser 
305                 310                 315                 320 


Ile Val Ser Leu Cys Asn His Leu Thr Arg Ser Leu Met Lys Lys Val 
                325                 330                 335     


His Leu Arg Pro Asp Glu Asp Leu Arg Asn Cys Glu Ser Asp Thr Glu 
            340                 345                 350         


Glu Asp Ile Ala Arg Arg Lys Ala Leu His Pro Arg Arg Arg Ser Ser 
        355                 360                 365             


Thr Ser 
    370 


<210>  36
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Val Asn Phe Val Ser Ala Gly Leu Phe Arg Cys Leu Pro Val Ser 
1               5                   10                  15      


Cys Pro Glu Asp Leu Leu Val Glu Glu Leu Val Asp Gly Leu Leu Ser 
            20                  25                  30          


Leu Glu Glu Glu Leu Lys Asp Lys Glu Glu Glu Glu Ala Val Leu Asp 
        35                  40                  45              


Gly Leu Leu Ser Leu Glu Glu Glu Ser Arg Gly Arg Leu Arg Arg Gly 
    50                  55                  60                  


Pro Pro Gly Glu Lys Ala Pro Pro Arg Gly Glu Thr His Arg Asp Arg 
65                  70                  75                  80  


Gln Arg Arg Ala Glu Glu Lys Arg Lys Arg Lys Lys Glu Arg Glu Lys 
                85                  90                  95      


Glu Glu Glu Lys Gln Thr Ala Glu Tyr Leu Lys Arg Lys Glu Glu Glu 
            100                 105                 110         


Lys Ala Arg Arg Arg Arg Arg Ala Glu Lys Lys Ala Ala Asp Val Ala 
        115                 120                 125             


Arg Arg Lys Gln Glu Glu Gln Glu Arg Arg Glu Arg Lys Trp Arg Gln 
    130                 135                 140                 


Gly Ala Glu Lys Ala Lys Gln His Ser Ala Arg Lys Glu Lys Met Gln 
145                 150                 155                 160 


Glu Leu Gly Ile Asp Gly Tyr Thr Arg Gln Leu Glu Gly Glu Val Glu 
                165                 170                 175     


Ser Leu Glu Ala Glu Arg Arg Lys Leu Leu Gln Glu Lys Glu Asp Leu 
            180                 185                 190         


Met Gly Glu Val Asn Tyr Trp Gln Gly Arg Leu Glu Ala Met Trp Leu 
        195                 200                 205             


Gln 
    


<210>  37
<211>  842
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Lys Gly Leu Cys Ala Glu Cys Gly Gln Asp Leu Thr Gln Leu Gln 
1               5                   10                  15      


Ser Lys Asn Gly Lys Gln Gln Val Pro Leu Ser Thr Ala Thr Val Ser 
            20                  25                  30          


Met Val His Ser Val Pro Glu Leu Met Val Ser Ser Glu Gln Ala Glu 
        35                  40                  45              


Gln Leu Gly Arg Glu Asp Gln Gln Arg Leu His Arg Asn Arg Lys Leu 
    50                  55                  60                  


Val Leu Met Val Asp Leu Asp Gln Thr Leu Ile His Thr Thr Glu Gln 
65                  70                  75                  80  


His Cys Gln Gln Met Ser Asn Lys Gly Ile Phe His Phe Gln Leu Gly 
                85                  90                  95      


Arg Gly Glu Pro Met Leu His Thr Arg Leu Arg Pro His Cys Lys Asp 
            100                 105                 110         


Phe Leu Glu Lys Ile Ala Lys Leu Tyr Glu Leu His Val Phe Thr Phe 
        115                 120                 125             


Gly Ser Arg Leu Tyr Ala His Thr Ile Ala Gly Phe Leu Asp Pro Glu 
    130                 135                 140                 


Lys Lys Leu Phe Ser His Arg Ile Leu Ser Arg Asp Glu Cys Ile Asp 
145                 150                 155                 160 


Pro Phe Ser Lys Thr Gly Asn Leu Arg Asn Leu Phe Pro Cys Gly Asp 
                165                 170                 175     


Ser Met Val Cys Ile Ile Asp Asp Arg Glu Asp Val Trp Lys Phe Ala 
            180                 185                 190         


Pro Asn Leu Ile Thr Val Lys Lys Tyr Val Tyr Phe Gln Gly Thr Gly 
        195                 200                 205             


Asp Met Asn Ala Pro Pro Gly Ser Arg Glu Ser Gln Thr Arg Lys Lys 
    210                 215                 220                 


Val Asn His Ser Arg Gly Thr Glu Val Ser Glu Pro Ser Pro Pro Val 
225                 230                 235                 240 


Arg Asp Pro Glu Gly Val Thr Gln Ala Pro Gly Val Glu Pro Ser Asn 
                245                 250                 255     


Gly Leu Glu Lys Pro Ala Arg Glu Leu Asn Gly Ser Glu Ala Ala Thr 
            260                 265                 270         


Pro Arg Asp Ser Pro Arg Pro Gly Lys Pro Asp Glu Arg Asp Ile Trp 
        275                 280                 285             


Pro Pro Ala Gln Ala Pro Thr Ser Ser Gln Glu Leu Ala Gly Ala Pro 
    290                 295                 300                 


Glu Pro Gln Gly Ser Cys Ala Gln Gly Gly Arg Val Ala Pro Gly Gln 
305                 310                 315                 320 


Arg Pro Ala Gln Gly Ala Thr Gly Thr Asp Leu Asp Phe Asp Leu Ser 
                325                 330                 335     


Ser Asp Ser Glu Ser Ser Ser Glu Ser Glu Gly Thr Lys Ser Ser Ser 
            340                 345                 350         


Ser Ala Ser Asp Gly Glu Ser Glu Gly Lys Arg Gly Arg Gln Lys Pro 
        355                 360                 365             


Lys Ala Ala Pro Glu Gly Ala Gly Ala Leu Ala Gln Gly Ser Ser Leu 
    370                 375                 380                 


Glu Pro Gly Arg Pro Ala Ala Pro Ser Leu Pro Gly Glu Ala Glu Pro 
385                 390                 395                 400 


Gly Ala His Ala Pro Asp Lys Glu Pro Glu Leu Gly Gly Gln Glu Glu 
                405                 410                 415     


Gly Glu Arg Asp Gly Leu Cys Gly Leu Gly Asn Gly Cys Ala Asp Arg 
            420                 425                 430         


Lys Glu Ala Glu Thr Glu Ser Gln Asn Ser Glu Leu Ser Gly Val Thr 
        435                 440                 445             


Ala Gly Glu Ser Leu Asp Gln Ser Met Glu Glu Glu Glu Glu Glu Asp 
    450                 455                 460                 


Thr Asp Glu Asp Asp His Leu Ile Tyr Leu Glu Glu Ile Leu Val Arg 
465                 470                 475                 480 


Val His Thr Asp Tyr Tyr Ala Lys Tyr Asp Arg Tyr Leu Asn Lys Glu 
                485                 490                 495     


Ile Glu Glu Ala Pro Asp Ile Arg Lys Ile Val Pro Glu Leu Lys Ser 
            500                 505                 510         


Lys Val Leu Ala Asp Val Ala Ile Ile Phe Ser Gly Leu His Pro Thr 
        515                 520                 525             


Asn Phe Pro Ile Glu Lys Thr Arg Glu His Tyr His Ala Thr Ala Leu 
    530                 535                 540                 


Gly Ala Lys Ile Leu Thr Arg Leu Val Leu Ser Pro Asp Ala Pro Asp 
545                 550                 555                 560 


Arg Ala Thr His Leu Ile Ala Ala Arg Ala Gly Thr Glu Lys Val Leu 
                565                 570                 575     


Gln Ala Gln Glu Cys Gly His Leu His Val Val Asn Pro Asp Trp Leu 
            580                 585                 590         


Trp Ser Cys Leu Glu Arg Trp Asp Lys Val Glu Glu Gln Leu Phe Pro 
        595                 600                 605             


Leu Arg Asp Asp His Thr Lys Ala Gln Arg Glu Asn Ser Pro Ala Ala 
    610                 615                 620                 


Phe Pro Asp Arg Glu Gly Val Pro Pro Thr Ala Leu Phe His Pro Met 
625                 630                 635                 640 


Pro Val Leu Pro Lys Ala Gln Pro Gly Pro Glu Val Arg Ile Tyr Asp 
                645                 650                 655     


Ser Asn Thr Gly Lys Leu Ile Arg Thr Gly Ala Arg Gly Pro Pro Ala 
            660                 665                 670         


Pro Ser Ser Ser Leu Pro Ile Arg Gln Glu Pro Ser Ser Phe Arg Ala 
        675                 680                 685             


Val Pro Pro Pro Gln Pro Gln Met Phe Gly Glu Glu Leu Pro Asp Ala 
    690                 695                 700                 


Gln Asp Gly Glu Gln Pro Gly Pro Ser Arg Arg Lys Arg Gln Pro Ser 
705                 710                 715                 720 


Met Ser Glu Thr Met Pro Leu Tyr Thr Leu Cys Lys Glu Asp Leu Glu 
                725                 730                 735     


Ser Met Asp Lys Glu Val Asp Asp Ile Leu Gly Glu Gly Ser Asp Asp 
            740                 745                 750         


Ser Asp Ser Glu Lys Arg Arg Pro Glu Glu Gln Glu Glu Glu Pro Gln 
        755                 760                 765             


Pro Arg Lys Pro Gly Thr Arg Arg Glu Arg Thr Leu Gly Ala Pro Ala 
    770                 775                 780                 


Ser Ser Glu Arg Ser Ala Ala Gly Gly Arg Gly Pro Arg Gly His Lys 
785                 790                 795                 800 


Arg Lys Leu Asn Glu Glu Asp Ala Ala Ser Glu Ser Ser Arg Glu Ser 
                805                 810                 815     


Ser Asn Glu Asp Glu Gly Ser Ser Ser Glu Ala Asp Glu Met Ala Lys 
            820                 825                 830         


Ala Leu Glu Ala Glu Leu Asn Asp Leu Met 
        835                 840         


<210>  38
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly 
        275                 280                 285             


Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu 
    290                 295                 300                 


Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg 
305                 310                 315                 320 


Arg Lys Arg Lys Arg Met Thr Asp Pro Thr Arg Arg Phe Phe Lys Val 
                325                 330                 335     


Thr Pro Pro Pro Gly Ser Gly Pro Gln Asn Gln Tyr Gly Asn Val Leu 
            340                 345                 350         


Ser Leu Pro Thr Pro Thr Ser Gly Leu Gly Arg Ala Gln Arg Trp Ala 
        355                 360                 365             


Ala Gly Leu Gly Gly Thr Ala Pro Ser Tyr Gly Asn Pro Ser Ser Asp 
    370                 375                 380                 


Val Gln Ala Asp Gly Ala Leu Gly Ser Arg Ser Pro Pro Gly Val Gly 
385                 390                 395                 400 


Pro Glu Glu Glu Glu Gly Glu Gly Tyr Glu Glu Pro Asp Ser Glu Glu 
                405                 410                 415     


Asp Ser Glu Phe Tyr Glu Asn Asp Ser Asn Leu Gly Gln Asp Gln Leu 
            420                 425                 430         


Ser Gln Asp Gly Ser Gly Tyr Glu Asn Pro Glu Asp Glu Pro Leu Gly 
        435                 440                 445             


Pro Glu Asp Glu Asp Ser Phe Ser Asn Ala Glu Ser Tyr Glu Asn Glu 
    450                 455                 460                 


Asp Glu Glu Leu Thr Gln Pro Val Ala Arg Thr Met Asp Phe Leu Ser 
465                 470                 475                 480 


Pro His Gly Ser Ala Trp Asp Pro Ser Arg Glu Ala Thr Ser Leu Gly 
                485                 490                 495     


Ser Gln Ser Tyr Glu Asp Met Arg Gly Ile Leu Tyr Ala Ala Pro Gln 
            500                 505                 510         


Leu Arg Ser Ile Arg Gly Gln Pro Gly Pro Asn His Glu Glu Asp Ala 
        515                 520                 525             


Asp Ser Tyr Glu Asn Met Asp Asn Pro Asp Gly Pro Asp Pro Ala Trp 
    530                 535                 540                 


Gly Gly Gly Gly Arg Met Gly Thr Trp Ser Thr Arg 
545                 550                 555     


<210>  39
<211>  724
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ser Phe Pro Lys Ala Pro Leu Lys Arg Phe Asn Asp Pro Ser Gly 
1               5                   10                  15      


Cys Ala Pro Ser Pro Gly Ala Tyr Asp Val Lys Thr Leu Glu Val Leu 
            20                  25                  30          


Lys Gly Pro Val Ser Phe Gln Lys Ser Gln Arg Phe Lys Gln Gln Lys 
        35                  40                  45              


Glu Ser Lys Gln Asn Leu Asn Val Asp Lys Asp Thr Thr Leu Pro Ala 
    50                  55                  60                  


Ser Ala Arg Lys Val Lys Ser Ser Glu Ser Lys Glu Ser Gln Lys Asn 
65                  70                  75                  80  


Asp Lys Asp Leu Lys Ile Leu Glu Lys Glu Ile Arg Val Leu Leu Gln 
                85                  90                  95      


Glu Arg Gly Ala Gln Asp Arg Arg Ile Gln Asp Leu Glu Thr Glu Leu 
            100                 105                 110         


Glu Lys Met Glu Ala Arg Leu Asn Ala Ala Leu Arg Glu Lys Thr Ser 
        115                 120                 125             


Leu Ser Ala Asn Asn Ala Thr Leu Glu Lys Gln Leu Ile Glu Leu Thr 
    130                 135                 140                 


Arg Thr Asn Glu Leu Leu Lys Ser Lys Phe Ser Glu Asn Gly Asn Gln 
145                 150                 155                 160 


Lys Asn Leu Arg Ile Leu Ser Leu Glu Leu Met Lys Leu Arg Asn Lys 
                165                 170                 175     


Arg Glu Thr Lys Met Arg Gly Met Met Ala Lys Gln Glu Gly Met Glu 
            180                 185                 190         


Met Lys Leu Gln Val Thr Gln Arg Ser Leu Glu Glu Ser Gln Gly Lys 
        195                 200                 205             


Ile Ala Gln Leu Glu Gly Lys Leu Val Ser Ile Glu Lys Glu Lys Ile 
    210                 215                 220                 


Asp Glu Lys Ser Glu Thr Glu Lys Leu Leu Glu Tyr Ile Glu Glu Ile 
225                 230                 235                 240 


Ser Cys Ala Ser Asp Gln Val Glu Lys Tyr Lys Leu Asp Ile Ala Gln 
                245                 250                 255     


Leu Glu Glu Asn Leu Lys Glu Lys Asn Asp Glu Ile Leu Ser Leu Lys 
            260                 265                 270         


Gln Ser Leu Glu Glu Asn Ile Val Ile Leu Ser Lys Gln Val Glu Asp 
        275                 280                 285             


Leu Asn Val Lys Cys Gln Leu Leu Glu Lys Glu Lys Glu Asp His Val 
    290                 295                 300                 


Asn Arg Asn Arg Glu His Asn Glu Asn Leu Asn Ala Glu Met Gln Asn 
305                 310                 315                 320 


Leu Lys Gln Lys Phe Ile Leu Glu Gln Gln Glu Arg Glu Lys Leu Gln 
                325                 330                 335     


Gln Lys Glu Leu Gln Ile Asp Ser Leu Leu Gln Gln Glu Lys Glu Leu 
            340                 345                 350         


Ser Ser Ser Leu His Gln Lys Leu Cys Ser Phe Gln Glu Glu Met Val 
        355                 360                 365             


Lys Glu Lys Asn Leu Phe Glu Glu Glu Leu Lys Gln Thr Leu Asp Glu 
    370                 375                 380                 


Leu Asp Lys Leu Gln Gln Lys Glu Glu Gln Ala Glu Arg Leu Val Lys 
385                 390                 395                 400 


Gln Leu Glu Glu Glu Ala Lys Ser Arg Ala Glu Glu Leu Lys Leu Leu 
                405                 410                 415     


Glu Glu Lys Leu Lys Gly Lys Glu Ala Glu Leu Glu Lys Ser Ser Ala 
            420                 425                 430         


Ala His Thr Gln Ala Thr Leu Leu Leu Gln Glu Lys Tyr Asp Ser Met 
        435                 440                 445             


Val Gln Ser Leu Glu Asp Val Thr Ala Gln Phe Glu Ser Tyr Lys Ala 
    450                 455                 460                 


Leu Thr Ala Ser Glu Ile Glu Asp Leu Lys Leu Glu Asn Ser Ser Leu 
465                 470                 475                 480 


Gln Glu Lys Ala Ala Lys Ala Gly Lys Asn Ala Glu Asp Val Gln His 
                485                 490                 495     


Gln Ile Leu Ala Thr Glu Ser Ser Asn Gln Glu Tyr Val Arg Met Leu 
            500                 505                 510         


Leu Asp Leu Gln Thr Lys Ser Ala Leu Lys Glu Thr Glu Ile Lys Glu 
        515                 520                 525             


Ile Thr Val Ser Phe Leu Gln Lys Ile Thr Asp Leu Gln Asn Gln Leu 
    530                 535                 540                 


Lys Gln Gln Glu Glu Asp Phe Arg Lys Gln Leu Glu Asp Glu Glu Gly 
545                 550                 555                 560 


Arg Lys Ala Glu Lys Glu Asn Thr Thr Ala Glu Leu Thr Glu Glu Ile 
                565                 570                 575     


Asn Lys Trp Arg Leu Leu Tyr Glu Glu Leu Tyr Asn Lys Thr Lys Pro 
            580                 585                 590         


Phe Gln Leu Gln Leu Asp Ala Phe Glu Val Glu Lys Gln Ala Leu Leu 
        595                 600                 605             


Asn Glu His Gly Ala Ala Gln Glu Gln Leu Asn Lys Ile Arg Asp Ser 
    610                 615                 620                 


Tyr Ala Lys Leu Leu Gly His Gln Asn Leu Lys Gln Lys Ile Lys His 
625                 630                 635                 640 


Val Val Lys Leu Lys Asp Glu Asn Ser Gln Leu Lys Ser Glu Val Ser 
                645                 650                 655     


Lys Leu Arg Cys Gln Leu Ala Lys Lys Lys Gln Ser Glu Thr Lys Leu 
            660                 665                 670         


Gln Glu Glu Leu Asn Lys Val Leu Gly Ile Lys His Phe Asp Pro Ser 
        675                 680                 685             


Lys Ala Phe His His Glu Ser Lys Glu Asn Phe Ala Leu Lys Thr Pro 
    690                 695                 700                 


Leu Lys Glu Gly Asn Thr Asn Cys Tyr Arg Ala Pro Met Glu Cys Gln 
705                 710                 715                 720 


Glu Ser Trp Lys 
                


<210>  40
<211>  437
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ala Ser Val Ala Val Asp Pro Gln Pro Ser Val Val Thr Arg Val 
1               5                   10                  15      


Val Asn Leu Pro Leu Val Ser Ser Thr Tyr Asp Leu Met Ser Ser Ala 
            20                  25                  30          


Tyr Leu Ser Thr Lys Asp Gln Tyr Pro Tyr Leu Lys Ser Val Cys Glu 
        35                  40                  45              


Met Ala Glu Asn Gly Val Lys Thr Ile Thr Ser Val Ala Met Thr Ser 
    50                  55                  60                  


Ala Leu Pro Ile Ile Gln Lys Leu Glu Pro Gln Ile Ala Val Ala Asn 
65                  70                  75                  80  


Thr Tyr Ala Cys Lys Gly Leu Asp Arg Ile Glu Glu Arg Leu Pro Ile 
                85                  90                  95      


Leu Asn Gln Pro Ser Thr Gln Ile Val Ala Asn Ala Lys Gly Ala Val 
            100                 105                 110         


Thr Gly Ala Lys Asp Ala Val Thr Thr Thr Val Thr Gly Ala Lys Asp 
        115                 120                 125             


Ser Val Ala Ser Thr Ile Thr Gly Val Met Asp Lys Thr Lys Gly Ala 
    130                 135                 140                 


Val Thr Gly Ser Val Glu Lys Thr Lys Ser Val Val Ser Gly Ser Ile 
145                 150                 155                 160 


Asn Thr Val Leu Gly Ser Arg Met Met Gln Leu Val Ser Ser Gly Val 
                165                 170                 175     


Glu Asn Ala Leu Thr Lys Ser Glu Leu Leu Val Glu Gln Tyr Leu Pro 
            180                 185                 190         


Leu Thr Glu Glu Glu Leu Glu Lys Glu Ala Lys Lys Val Glu Gly Phe 
        195                 200                 205             


Asp Leu Val Gln Lys Pro Ser Tyr Tyr Val Arg Leu Gly Ser Leu Ser 
    210                 215                 220                 


Thr Lys Leu His Ser Arg Ala Tyr Gln Gln Ala Leu Ser Arg Val Lys 
225                 230                 235                 240 


Glu Ala Lys Gln Lys Ser Gln Gln Thr Ile Ser Gln Leu His Ser Thr 
                245                 250                 255     


Val His Leu Ile Glu Phe Ala Arg Lys Asn Val Tyr Ser Ala Asn Gln 
            260                 265                 270         


Lys Ile Gln Asp Ala Gln Asp Lys Leu Tyr Leu Ser Trp Val Glu Trp 
        275                 280                 285             


Lys Arg Ser Ile Gly Tyr Asp Asp Thr Asp Glu Ser His Cys Ala Glu 
    290                 295                 300                 


His Ile Glu Ser Arg Thr Leu Ala Ile Ala Arg Asn Leu Thr Gln Gln 
305                 310                 315                 320 


Leu Gln Thr Thr Cys His Thr Leu Leu Ser Asn Ile Gln Gly Val Pro 
                325                 330                 335     


Gln Asn Ile Gln Asp Gln Ala Lys His Met Gly Val Met Ala Gly Asp 
            340                 345                 350         


Ile Tyr Ser Val Phe Arg Asn Ala Ala Ser Phe Lys Glu Val Ser Asp 
        355                 360                 365             


Ser Leu Leu Thr Ser Ser Lys Gly Gln Leu Gln Lys Met Lys Glu Ser 
    370                 375                 380                 


Leu Asp Asp Val Met Asp Tyr Leu Val Asn Asn Thr Pro Leu Asn Trp 
385                 390                 395                 400 


Leu Val Gly Pro Phe Tyr Pro Gln Leu Thr Glu Ser Gln Asn Ala Gln 
                405                 410                 415     


Asp Gln Gly Ala Glu Met Asp Lys Ser Ser Gln Glu Thr Gln Arg Ser 
            420                 425                 430         


Glu His Lys Thr His 
        435         


<210>  41
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Glu Arg Arg Arg Leu Trp Gly Ser Ile Gln Ser Arg Tyr Ile Ser 
1               5                   10                  15      


Met Ser Val Trp Thr Ser Pro Arg Arg Leu Val Glu Leu Ala Gly Gln 
            20                  25                  30          


Ser Leu Leu Lys Asp Glu Ala Leu Ala Ile Ala Ala Leu Glu Leu Leu 
        35                  40                  45              


Pro Arg Glu Leu Phe Pro Pro Leu Phe Met Ala Ala Phe Asp Gly Arg 
    50                  55                  60                  


His Ser Gln Thr Leu Lys Ala Met Val Gln Ala Trp Pro Phe Thr Cys 
65                  70                  75                  80  


Leu Pro Leu Gly Val Leu Met Lys Gly Gln His Leu His Leu Glu Thr 
                85                  90                  95      


Phe Lys Ala Val Leu Asp Gly Leu Asp Val Leu Leu Ala Gln Glu Val 
            100                 105                 110         


Arg Pro Arg Arg Trp Lys Leu Gln Val Leu Asp Leu Arg Lys Asn Ser 
        115                 120                 125             


His Gln Asp Phe Trp Thr Val Trp Ser Gly Asn Arg Ala Ser Leu Tyr 
    130                 135                 140                 


Ser Phe Pro Glu Pro Glu Ala Ala Gln Pro Met Thr Lys Lys Arg Lys 
145                 150                 155                 160 


Val Asp Gly Leu Ser Thr Glu Ala Glu Gln Pro Phe Ile Pro Val Glu 
                165                 170                 175     


Val Leu Val Asp Leu Phe Leu Lys Glu Gly Ala Cys Asp Glu Leu Phe 
            180                 185                 190         


Ser Tyr Leu Ile Glu Lys Val Lys Arg Lys Lys Asn Val Leu Arg Leu 
        195                 200                 205             


Cys Cys Lys Lys Leu Lys Ile Phe Ala Met Pro Met Gln Asp Ile Lys 
    210                 215                 220                 


Met Ile Leu Lys Met Val Gln Leu Asp Ser Ile Glu Asp Leu Glu Val 
225                 230                 235                 240 


Thr Cys Thr Trp Lys Leu Pro Thr Leu Ala Lys Phe Ser Pro Tyr Leu 
                245                 250                 255     


Gly Gln Met Ile Asn Leu Arg Arg Leu Leu Leu Ser His Ile His Ala 
            260                 265                 270         


Ser Ser Tyr Ile Ser Pro Glu Lys Glu Glu Gln Tyr Ile Ala Gln Phe 
        275                 280                 285             


Thr Ser Gln Phe Leu Ser Leu Gln Cys Leu Gln Ala Leu Tyr Val Asp 
    290                 295                 300                 


Ser Leu Phe Phe Leu Arg Gly Arg Leu Asp Gln Leu Leu Arg His Val 
305                 310                 315                 320 


Met Asn Pro Leu Glu Thr Leu Ser Ile Thr Asn Cys Arg Leu Ser Glu 
                325                 330                 335     


Gly Asp Val Met His Leu Ser Gln Ser Pro Ser Val Ser Gln Leu Ser 
            340                 345                 350         


Val Leu Ser Leu Ser Gly Val Met Leu Thr Asp Val Ser Pro Glu Pro 
        355                 360                 365             


Leu Gln Ala Leu Leu Glu Arg Ala Ser Ala Thr Leu Gln Asp Leu Val 
    370                 375                 380                 


Phe Asp Glu Cys Gly Ile Thr Asp Asp Gln Leu Leu Ala Leu Leu Pro 
385                 390                 395                 400 


Ser Leu Ser His Cys Ser Gln Leu Thr Thr Leu Ser Phe Tyr Gly Asn 
                405                 410                 415     


Ser Ile Ser Ile Ser Ala Leu Gln Ser Leu Leu Gln His Leu Ile Gly 
            420                 425                 430         


Leu Ser Asn Leu Thr His Val Leu Tyr Pro Val Pro Leu Glu Ser Tyr 
        435                 440                 445             


Glu Asp Ile His Gly Thr Leu His Leu Glu Arg Leu Ala Tyr Leu His 
    450                 455                 460                 


Ala Arg Leu Arg Glu Leu Leu Cys Glu Leu Gly Arg Pro Ser Met Val 
465                 470                 475                 480 


Trp Leu Ser Ala Asn Pro Cys Pro His Cys Gly Asp Arg Thr Phe Tyr 
                485                 490                 495     


Asp Pro Glu Pro Ile Leu Cys Pro Cys Phe Met Pro Asn 
            500                 505                 


<210>  42
<211>  356
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ala Pro Leu Cys Pro Ser Pro Trp Leu Pro Leu Leu Ile Pro Ala 
1               5                   10                  15      


Pro Ala Pro Gly Leu Thr Val Gln Leu Leu Leu Ser Leu Leu Leu Leu 
            20                  25                  30          


Val Pro Val His Pro Gln Arg Leu Pro Arg Met Gln Glu Asp Ser Pro 
        35                  40                  45              


Leu Gly Gly Gly Ser Ser Gly Glu Asp Asp Pro Leu Gly Glu Glu Asp 
    50                  55                  60                  


Leu Pro Ser Glu Glu Asp Ser Pro Arg Glu Glu Asp Pro Pro Gly Glu 
65                  70                  75                  80  


Glu Asp Leu Pro Gly Glu Glu Asp Leu Pro Gly Glu Glu Asp Leu Pro 
                85                  90                  95      


Glu Val Lys Pro Lys Ser Glu Glu Glu Gly Ser Leu Lys Leu Glu Asp 
            100                 105                 110         


Leu Pro Thr Val Glu Ala Pro Gly Asp Pro Gln Glu Pro Gln Asn Asn 
        115                 120                 125             


Ala His Arg Asp Lys Glu Gly Asp Asp Gln Ser His Trp Arg Tyr Gly 
    130                 135                 140                 


Gly Asp Pro Pro Trp Pro Arg Val Ser Pro Ala Cys Ala Gly Arg Phe 
145                 150                 155                 160 


Gln Ser Pro Val Asp Ile Arg Pro Gln Leu Ala Ala Phe Cys Pro Ala 
                165                 170                 175     


Leu Arg Pro Leu Glu Leu Leu Gly Phe Gln Leu Pro Pro Leu Pro Glu 
            180                 185                 190         


Leu Arg Leu Arg Asn Asn Gly His Ser Val Gln Leu Thr Leu Pro Pro 
        195                 200                 205             


Gly Leu Glu Met Ala Leu Gly Pro Gly Arg Glu Tyr Arg Ala Leu Gln 
    210                 215                 220                 


Leu His Leu His Trp Gly Ala Ala Gly Arg Pro Gly Ser Glu His Thr 
225                 230                 235                 240 


Val Glu Gly His Arg Phe Pro Ala Glu Ile His Val Val His Leu Ser 
                245                 250                 255     


Thr Ala Phe Ala Arg Val Asp Glu Ala Leu Gly Arg Pro Gly Gly Leu 
            260                 265                 270         


Ala Val Leu Ala Ala Phe Leu Glu Glu Gly Pro Glu Glu Asn Ser Ala 
        275                 280                 285             


Tyr Glu Gln Leu Leu Ser Arg Leu Glu Glu Ile Ala Glu Glu Gly Ser 
    290                 295                 300                 


Glu Thr Gln Val Pro Gly Leu Asp Ile Ser Ala Leu Leu Pro Ser Asp 
305                 310                 315                 320 


Phe Ser Arg Tyr Phe Gln Tyr Glu Gly Ser Leu Thr Thr Pro Pro Cys 
                325                 330                 335     


Ala Gln Gly Val Ile Trp Thr Val Phe Asn Gln Thr Val Met Leu Ser 
            340                 345                 350         


Ala Lys Gln Ser 
        355     


<210>  43
<211>  1273
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Gln Lys Gly Ile Arg Leu Asn Asp Gly His Val Ala Ser Leu Gly 
1               5                   10                  15      


Leu Leu Ala Arg Lys Asp Gly Thr Arg Lys Gly Tyr Leu Ser Lys Arg 
            20                  25                  30          


Ser Ser Asp Asn Thr Lys Trp Gln Thr Lys Trp Phe Ala Leu Leu Gln 
        35                  40                  45              


Asn Leu Leu Phe Tyr Phe Glu Ser Asp Ser Ser Ser Arg Pro Ser Gly 
    50                  55                  60                  


Leu Tyr Leu Leu Glu Gly Cys Val Cys Asp Arg Ala Pro Ser Pro Lys 
65                  70                  75                  80  


Pro Ala Leu Ser Ala Lys Glu Pro Leu Glu Lys Gln His Tyr Phe Thr 
                85                  90                  95      


Val Asn Phe Ser His Glu Asn Gln Lys Ala Leu Glu Leu Arg Thr Glu 
            100                 105                 110         


Asp Ala Lys Asp Cys Asp Glu Trp Val Ala Ala Ile Ala His Ala Ser 
        115                 120                 125             


Tyr Arg Thr Leu Ala Thr Glu His Glu Ala Leu Met Gln Lys Tyr Leu 
    130                 135                 140                 


His Leu Leu Gln Ile Val Glu Thr Glu Lys Thr Val Ala Lys Gln Leu 
145                 150                 155                 160 


Arg Gln Gln Ile Glu Asp Gly Glu Ile Glu Ile Glu Arg Leu Lys Ala 
                165                 170                 175     


Glu Ile Thr Ser Leu Leu Lys Asp Asn Glu Arg Ile Gln Ser Thr Gln 
            180                 185                 190         


Thr Val Ala Pro Asn Asp Glu Asp Ser Asp Ile Lys Lys Ile Lys Lys 
        195                 200                 205             


Val Gln Ser Phe Leu Arg Gly Trp Leu Cys Arg Arg Lys Trp Lys Thr 
    210                 215                 220                 


Ile Ile Gln Asp Tyr Ile Arg Ser Pro His Ala Asp Ser Met Arg Lys 
225                 230                 235                 240 


Arg Asn Gln Val Val Phe Ser Met Leu Glu Ala Glu Ala Glu Tyr Val 
                245                 250                 255     


Gln Gln Leu His Ile Leu Val Asn Asn Phe Leu Arg Pro Leu Arg Met 
            260                 265                 270         


Ala Ala Ser Ser Lys Lys Pro Pro Ile Thr His Asp Asp Val Ser Ser 
        275                 280                 285             


Ile Phe Leu Asn Ser Glu Thr Ile Met Phe Leu His Gln Ile Phe Tyr 
    290                 295                 300                 


Gln Gly Leu Lys Ala Arg Ile Ser Ser Trp Pro Thr Leu Val Leu Ala 
305                 310                 315                 320 


Asp Leu Phe Asp Ile Leu Leu Pro Met Leu Asn Ile Tyr Gln Glu Phe 
                325                 330                 335     


Val Arg Asn His Gln Tyr Ser Leu Gln Ile Leu Ala His Cys Lys Gln 
            340                 345                 350         


Asn Arg Asp Phe Asp Lys Leu Leu Lys His Tyr Glu Ala Lys Pro Asp 
        355                 360                 365             


Cys Glu Glu Arg Thr Leu Glu Thr Phe Leu Thr Tyr Pro Met Phe Gln 
    370                 375                 380                 


Ile Pro Arg Tyr Ile Leu Thr Leu His Glu Leu Leu Ala His Thr Pro 
385                 390                 395                 400 


His Glu His Val Glu Arg Asn Ser Leu Asp Tyr Ala Lys Ser Lys Leu 
                405                 410                 415     


Glu Glu Leu Ser Arg Ile Met His Asp Glu Val Ser Glu Thr Glu Asn 
            420                 425                 430         


Ile Arg Lys Asn Leu Ala Ile Glu Arg Met Ile Ile Glu Gly Cys Glu 
        435                 440                 445             


Ile Leu Leu Asp Thr Ser Gln Thr Phe Val Arg Gln Gly Ser Leu Ile 
    450                 455                 460                 


Gln Val Pro Met Ser Glu Lys Gly Lys Ile Thr Arg Gly Arg Leu Gly 
465                 470                 475                 480 


Ser Leu Ser Leu Lys Lys Glu Gly Glu Arg Gln Cys Phe Leu Phe Ser 
                485                 490                 495     


Lys His Leu Ile Ile Cys Thr Arg Gly Ser Gly Gly Lys Leu His Leu 
            500                 505                 510         


Thr Lys Asn Gly Val Ile Ser Leu Ile Asp Cys Thr Leu Leu Glu Glu 
        515                 520                 525             


Pro Glu Ser Thr Glu Glu Glu Ala Lys Gly Ser Gly Gln Asp Ile Asp 
    530                 535                 540                 


His Leu Asp Phe Lys Ile Gly Val Glu Pro Lys Asp Ser Pro Pro Phe 
545                 550                 555                 560 


Thr Val Ile Leu Val Ala Ser Ser Arg Gln Glu Lys Ala Ala Trp Thr 
                565                 570                 575     


Ser Asp Ile Ser Gln Cys Val Asp Asn Ile Arg Cys Asn Gly Leu Met 
            580                 585                 590         


Met Asn Ala Phe Glu Glu Asn Ser Lys Val Thr Val Pro Gln Met Ile 
        595                 600                 605             


Lys Arg Thr Arg Glu Gly Thr Arg Glu Ala Glu Met Ser Arg Ser Asp 
    610                 615                 620                 


Ala Ser Leu Tyr Cys Asp Asp Val Asp Ile Arg Phe Ser Lys Thr Met 
625                 630                 635                 640 


Asn Ser Cys Lys Val Leu Gln Ile Arg Tyr Ala Ser Val Glu Arg Leu 
                645                 650                 655     


Leu Glu Arg Leu Thr Asp Leu Arg Phe Leu Ser Ile Asp Phe Leu Asn 
            660                 665                 670         


Thr Phe Leu His Ser Tyr Arg Val Phe Thr Thr Ala Ile Val Val Leu 
        675                 680                 685             


Asp Lys Leu Ile Thr Ile Tyr Lys Lys Pro Ile Ser Ala Ile Pro Ala 
    690                 695                 700                 


Arg Trp Leu Arg Ser Leu Glu Leu Leu Phe Ala Ser Gly Gln Asn Asn 
705                 710                 715                 720 


Lys Leu Leu Tyr Gly Glu Pro Pro Lys Ser Pro Arg Ala Thr Arg Lys 
                725                 730                 735     


Phe Ser Ser Pro Pro Pro Leu Ser Ile Thr Lys Thr Ser Ser Pro Ser 
            740                 745                 750         


Arg Arg Arg Lys Leu Ser Leu Asn Ile Pro Ile Ile Thr Gly Gly Lys 
        755                 760                 765             


Ala Leu Asp Leu Ala Ala Leu Ser Cys Asn Ser Asn Gly Tyr Thr Ser 
    770                 775                 780                 


Met Tyr Ser Ala Met Ser Pro Phe Ser Lys Ala Thr Leu Asp Thr Ser 
785                 790                 795                 800 


Lys Leu Tyr Val Ser Ser Ser Phe Thr Asn Lys Ile Pro Asp Glu Gly 
                805                 810                 815     


Asp Thr Thr Pro Glu Lys Pro Glu Asp Pro Ser Ala Leu Ser Lys Gln 
            820                 825                 830         


Ser Ser Glu Val Ser Met Arg Glu Glu Ser Asp Ile Asp Gln Asn Gln 
        835                 840                 845             


Ser Asp Asp Gly Asp Thr Glu Thr Ser Pro Thr Lys Ser Pro Thr Thr 
    850                 855                 860                 


Pro Lys Ser Val Lys Asn Lys Asn Ser Ser Glu Phe Pro Leu Phe Ser 
865                 870                 875                 880 


Tyr Asn Asn Gly Val Val Met Thr Ser Cys Arg Glu Leu Asp Asn Asn 
                885                 890                 895     


Arg Ser Ala Leu Ser Ala Ala Ser Ala Phe Ala Ile Ala Thr Ala Gly 
            900                 905                 910         


Ala Asn Glu Gly Thr Pro Asn Lys Glu Lys Tyr Arg Arg Met Ser Leu 
        915                 920                 925             


Ala Ser Ala Gly Phe Pro Pro Asp Gln Arg Asn Gly Asp Lys Glu Phe 
    930                 935                 940                 


Val Ile Arg Arg Ala Ala Thr Asn Arg Val Leu Asn Val Leu Arg His 
945                 950                 955                 960 


Trp Val Ser Lys His Ser Gln Asp Phe Glu Thr Asn Asp Glu Leu Lys 
                965                 970                 975     


Cys Lys Val Ile Gly Phe Leu Glu Glu Val Met His Asp Pro Glu Leu 
            980                 985                 990         


Leu Thr Gln Glu Arg Lys Ala Ala  Ala Asn Ile Ile Arg  Thr Leu Thr 
        995                 1000                 1005             


Gln Glu  Asp Pro Gly Asp Asn  Gln Ile Thr Leu Glu  Glu Ile Thr 
    1010                 1015                 1020             


Gln Met  Ala Glu Gly Val Lys  Ala Glu Pro Phe Glu  Asn His Ser 
    1025                 1030                 1035             


Ala Leu  Glu Ile Ala Glu Gln  Leu Thr Leu Leu Asp  His Leu Val 
    1040                 1045                 1050             


Phe Lys  Lys Ile Pro Tyr Glu  Glu Phe Phe Gly Gln  Gly Trp Met 
    1055                 1060                 1065             


Lys Leu  Glu Lys Asn Glu Arg  Thr Pro Tyr Ile Met  Lys Thr Thr 
    1070                 1075                 1080             


Lys His  Phe Asn Asp Ile Ser  Asn Leu Ile Ala Ser  Glu Ile Ile 
    1085                 1090                 1095             


Arg Asn  Glu Asp Ile Asn Ala  Arg Val Ser Ala Ile  Glu Lys Trp 
    1100                 1105                 1110             


Val Ala  Val Ala Asp Ile Cys  Arg Cys Leu His Asn  Tyr Asn Ala 
    1115                 1120                 1125             


Val Leu  Glu Ile Thr Ser Ser  Met Asn Arg Ser Ala  Ile Phe Arg 
    1130                 1135                 1140             


Leu Lys  Lys Thr Trp Leu Lys  Val Ser Lys Gln Thr  Lys Ala Leu 
    1145                 1150                 1155             


Ile Asp  Lys Leu Gln Lys Leu  Val Ser Ser Glu Gly  Arg Phe Lys 
    1160                 1165                 1170             


Asn Leu  Arg Glu Ala Leu Lys  Asn Cys Asp Pro Pro  Cys Val Pro 
    1175                 1180                 1185             


Tyr Leu  Gly Met Tyr Leu Thr  Asp Leu Ala Phe Ile  Glu Glu Gly 
    1190                 1195                 1200             


Thr Pro  Asn Tyr Thr Glu Asp  Gly Leu Val Asn Phe  Ser Lys Met 
    1205                 1210                 1215             


Arg Met  Ile Ser His Ile Ile  Arg Glu Ile Arg Gln  Phe Gln Gln 
    1220                 1225                 1230             


Thr Ala  Tyr Lys Ile Glu His  Gln Ala Lys Val Thr  Gln Tyr Leu 
    1235                 1240                 1245             


Leu Asp  Gln Ser Phe Val Met  Asp Glu Glu Ser Leu  Tyr Glu Ser 
    1250                 1255                 1260             


Ser Leu  Arg Ile Glu Pro Lys  Leu Pro Thr 
    1265                 1270             


<210>  44
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Ala Ala Lys Gln Pro Pro Pro Leu Met Lys Lys His Ser Gln Thr 
1               5                   10                  15      


Asp Leu Val Ser Arg Leu Lys Thr Arg Lys Ile Leu Gly Val Gly Gly 
            20                  25                  30          


Glu Asp Asp Asp Gly Glu Val His Arg Ser Lys Ile Ser Gln Val Leu 
        35                  40                  45              


Gly Asn Glu Ile Lys Phe Thr Ile Arg Glu Pro Leu Gly Leu Arg Val 
    50                  55                  60                  


Trp Gln Phe Val Ser Ala Val Leu Phe Ser Gly Ile Ala Ile Met Ala 
65                  70                  75                  80  


Leu Ala Phe Pro Asp Gln Leu Tyr Asp Ala Val Phe Asp Gly Ala Gln 
                85                  90                  95      


Val Thr Ser Lys Thr Pro Ile Arg Leu Tyr Gly Gly Ala Leu Leu Asn 
            100                 105                 110         


Ala Ala Pro Thr Pro Arg Pro Leu Met Lys Leu Ser Ala Gly Asp Val 
        115                 120                 125             


Leu Pro Ser Cys Gly His Trp Trp Asn Thr Pro Ser Gly Leu Glu Leu 
    130                 135                 140                 


Ala Val Ala Thr Ile Cys Lys Glu Arg Ser 
145                 150                 


<210>  45
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Cys Asn Thr Asn Met Ser Val Pro Thr Asp Gly Ala Val Thr Thr 
1               5                   10                  15      


Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr Leu Val Arg Pro Lys Pro 
            20                  25                  30          


Leu Leu Leu Lys Leu Leu Lys Ser Val Gly Ala Gln Lys Asp Thr Tyr 
        35                  40                  45              


Thr Met Lys Glu Val Leu Phe Tyr Leu Gly Gln Tyr Ile Met Thr Lys 
    50                  55                  60                  


Arg Leu Tyr Asp Glu Lys Gln Gln His Ile Val Tyr Cys Ser Asn Asp 
65                  70                  75                  80  


Leu Leu Gly Asp Leu Phe Gly Val Pro Ser Phe Ser Val Lys Glu His 
                85                  90                  95      


Arg Lys Ile Tyr Thr Met Ile Tyr Arg Asn Leu Val Val Val Asn Gln 
            100                 105                 110         


Gln Glu Ser Ser Asp Ser Gly Thr Ser Val Ser Glu Asn Arg Cys His 
        115                 120                 125             


Leu Glu Gly Gly Ser Asp Gln Lys Asp Leu Val Gln Glu Leu Gln Glu 
    130                 135                 140                 


Glu Lys Pro Ser Ser Ser His Leu Val Ser Arg Pro Ser Thr Ser Ser 
145                 150                 155                 160 


Arg Arg Arg Ala Ile Ser Glu Thr Glu Glu Asn Ser Asp Glu Leu Ser 
                165                 170                 175     


Gly Glu Arg Gln Arg Lys Arg His Lys Ser Asp Ser Ile Ser Leu Ser 
            180                 185                 190         


Phe Asp Glu Ser Leu Ala Leu Cys Val Ile Arg Glu Ile Cys Cys Glu 
        195                 200                 205             


Arg Ser Ser Ser Ser Glu Ser Thr Gly Thr Pro Ser Asn Pro Asp Leu 
    210                 215                 220                 


Asp Ala Gly Val Ser Glu His Ser Gly Asp Trp Leu Asp Gln Asp Ser 
225                 230                 235                 240 


Val Ser Asp Gln Phe Ser Val Glu Phe Glu Val Glu Ser Leu Asp Ser 
                245                 250                 255     


Glu Asp Tyr Ser Leu Ser Glu Glu Gly Gln Glu Leu Ser Asp Glu Asp 
            260                 265                 270         


Asp Glu Val Tyr Gln Val Thr Val Tyr Gln Ala Gly Glu Ser Asp Thr 
        275                 280                 285             


Asp Ser Phe Glu Glu Asp Pro Glu Ile Ser Leu Ala Asp Tyr Trp Lys 
    290                 295                 300                 


Cys Thr Ser Cys Asn Glu Met Asn Pro Pro Leu Pro Ser His Cys Asn 
305                 310                 315                 320 


Arg Cys Trp Ala Leu Arg Glu Asn Trp Leu Pro Glu Asp Lys Gly Lys 
                325                 330                 335     


Asp Lys Gly Glu Ile Ser Glu Lys Ala Lys Leu Glu Asn Ser Thr Gln 
            340                 345                 350         


Ala Glu Glu Gly Phe Asp Val Pro Asp Cys Lys Lys Thr Ile Val Asn 
        355                 360                 365             


Asp Ser Arg Glu Ser Cys Val Glu Glu Asn Asp Asp Lys Ile Thr Gln 
    370                 375                 380                 


Ala Ser Gln Ser Gln Glu Ser Glu Asp Tyr Ser Gln Pro Ser Thr Ser 
385                 390                 395                 400 


Ser Ser Ile Ile Tyr Ser Ser Gln Glu Asp Val Lys Glu Phe Glu Arg 
                405                 410                 415     


Glu Glu Thr Gln Asp Lys Glu Glu Ser Val Glu Ser Ser Leu Pro Leu 
            420                 425                 430         


Asn Ala Ile Glu Pro Cys Val Ile Cys Gln Gly Arg Pro Lys Asn Gly 
        435                 440                 445             


Cys Ile Val His Gly Lys Thr Gly His Leu Met Ala Cys Phe Thr Cys 
    450                 455                 460                 


Ala Lys Lys Leu Lys Lys Arg Asn Lys Pro Cys Pro Val Cys Arg Gln 
465                 470                 475                 480 


Pro Ile Gln Met Ile Val Leu Thr Tyr Phe Pro 
                485                 490     


<210>  46
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Arg Val Asn Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser 
1               5                   10                  15      


Glu Leu Asp Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe 
            20                  25                  30          


Glu Thr Ser Ala Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Cys 
        35                  40                  45              


Lys Met Trp Ala Ile Gly Ile Thr Val Leu Val Ile Phe Ile Ile Ile 
    50                  55                  60                  


Ile Ile Val Trp Val Val Ser Ser 
65                  70          


<210>  47
<211>  533
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ala Pro Lys Pro Lys Pro Trp Val Gln Thr Glu Gly Pro Glu Lys 
1               5                   10                  15      


Lys Lys Gly Arg Gln Ala Gly Arg Glu Glu Asp Pro Phe Arg Ser Thr 
            20                  25                  30          


Ala Glu Ala Leu Lys Ala Ile Pro Ala Glu Lys Arg Ile Ile Arg Val 
        35                  40                  45              


Asp Pro Thr Cys Pro Leu Ser Ser Asn Pro Gly Thr Gln Val Tyr Glu 
    50                  55                  60                  


Asp Tyr Asn Cys Thr Leu Asn Gln Thr Asn Ile Glu Asn Asn Asn Asn 
65                  70                  75                  80  


Lys Phe Tyr Ile Ile Gln Leu Leu Gln Asp Ser Asn Arg Phe Phe Thr 
                85                  90                  95      


Cys Trp Asn Arg Trp Gly Arg Val Gly Glu Val Gly Gln Ser Lys Ile 
            100                 105                 110         


Asn His Phe Thr Arg Leu Glu Asp Ala Lys Lys Asp Phe Glu Lys Lys 
        115                 120                 125             


Phe Arg Glu Lys Thr Lys Asn Asn Trp Ala Glu Arg Asp His Phe Val 
    130                 135                 140                 


Ser His Pro Gly Lys Tyr Thr Leu Ile Glu Val Gln Ala Glu Asp Glu 
145                 150                 155                 160 


Ala Gln Glu Ala Val Val Lys Val Asp Arg Gly Pro Val Arg Thr Val 
                165                 170                 175     


Thr Lys Arg Val Gln Pro Cys Ser Leu Asp Pro Ala Thr Gln Lys Leu 
            180                 185                 190         


Ile Thr Asn Ile Phe Ser Lys Glu Met Phe Lys Asn Thr Met Ala Leu 
        195                 200                 205             


Met Asp Leu Asp Val Lys Lys Met Pro Leu Gly Lys Leu Ser Lys Gln 
    210                 215                 220                 


Gln Ile Ala Arg Gly Phe Glu Ala Leu Glu Ala Leu Glu Glu Ala Leu 
225                 230                 235                 240 


Lys Gly Pro Thr Asp Gly Gly Gln Ser Leu Glu Glu Leu Ser Ser His 
                245                 250                 255     


Phe Tyr Thr Val Ile Pro His Asn Phe Gly His Ser Gln Pro Pro Pro 
            260                 265                 270         


Ile Asn Ser Pro Glu Leu Leu Gln Ala Lys Lys Asp Met Leu Leu Val 
        275                 280                 285             


Leu Ala Asp Ile Glu Leu Ala Gln Ala Leu Gln Ala Val Ser Glu Gln 
    290                 295                 300                 


Glu Lys Thr Val Glu Glu Val Pro His Pro Leu Asp Arg Asp Tyr Gln 
305                 310                 315                 320 


Leu Leu Lys Cys Gln Leu Gln Leu Leu Asp Ser Gly Ala Pro Glu Tyr 
                325                 330                 335     


Lys Val Ile Gln Thr Tyr Leu Glu Gln Thr Gly Ser Asn His Arg Cys 
            340                 345                 350         


Pro Thr Leu Gln His Ile Trp Lys Val Asn Gln Glu Gly Glu Glu Asp 
        355                 360                 365             


Arg Phe Gln Ala His Ser Lys Leu Gly Asn Arg Lys Leu Leu Trp His 
    370                 375                 380                 


Gly Thr Asn Met Ala Val Val Ala Ala Ile Leu Thr Ser Gly Leu Arg 
385                 390                 395                 400 


Ile Met Pro His Ser Gly Gly Arg Val Gly Lys Gly Ile Tyr Phe Ala 
                405                 410                 415     


Ser Glu Asn Ser Lys Ser Ala Gly Tyr Val Ile Gly Met Lys Cys Gly 
            420                 425                 430         


Ala His His Val Gly Tyr Met Phe Leu Gly Glu Val Ala Leu Gly Arg 
        435                 440                 445             


Glu His His Ile Asn Thr Asp Asn Pro Ser Leu Lys Ser Pro Pro Pro 
    450                 455                 460                 


Gly Phe Asp Ser Val Ile Ala Arg Gly His Thr Glu Pro Asp Pro Thr 
465                 470                 475                 480 


Gln Asp Thr Glu Leu Glu Leu Asp Gly Gln Gln Val Val Val Pro Gln 
                485                 490                 495     


Gly Gln Pro Val Pro Cys Pro Glu Phe Ser Ser Ser Thr Phe Ser Gln 
            500                 505                 510         


Ser Glu Tyr Leu Ile Tyr Gln Glu Ser Gln Cys Arg Leu Arg Tyr Leu 
        515                 520                 525             


Leu Glu Val His Leu 
    530             


<210>  48
<211>  1617
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Asn Met Lys Gln Lys Ser Val Tyr Gln Gln Thr Lys Ala Leu Leu 
1               5                   10                  15      


Cys Lys Asn Phe Leu Lys Lys Trp Arg Met Lys Arg Glu Ser Leu Leu 
            20                  25                  30          


Glu Trp Gly Leu Ser Ile Leu Leu Gly Leu Cys Ile Ala Leu Phe Ser 
        35                  40                  45              


Ser Ser Met Arg Asn Val Gln Phe Pro Gly Met Ala Pro Gln Asn Leu 
    50                  55                  60                  


Gly Arg Val Asp Lys Phe Asn Ser Ser Ser Leu Met Val Val Tyr Thr 
65                  70                  75                  80  


Pro Ile Ser Asn Leu Thr Gln Gln Ile Met Asn Lys Thr Ala Leu Ala 
                85                  90                  95      


Pro Leu Leu Lys Gly Thr Ser Val Ile Gly Ala Pro Asn Lys Thr His 
            100                 105                 110         


Met Asp Glu Ile Leu Leu Glu Asn Leu Pro Tyr Ala Met Gly Ile Ile 
        115                 120                 125             


Phe Asn Glu Thr Phe Ser Tyr Lys Leu Ile Phe Phe Gln Gly Tyr Asn 
    130                 135                 140                 


Ser Pro Leu Trp Lys Glu Asp Phe Ser Ala His Cys Trp Asp Gly Tyr 
145                 150                 155                 160 


Gly Glu Phe Ser Cys Thr Leu Thr Lys Tyr Trp Asn Arg Gly Phe Val 
                165                 170                 175     


Ala Leu Gln Thr Ala Ile Asn Thr Ala Ile Ile Glu Ile Thr Thr Asn 
            180                 185                 190         


His Pro Val Met Glu Glu Leu Met Ser Val Thr Ala Ile Thr Met Lys 
        195                 200                 205             


Thr Leu Pro Phe Ile Thr Lys Asn Leu Leu His Asn Glu Met Phe Ile 
    210                 215                 220                 


Leu Phe Phe Leu Leu His Phe Ser Pro Leu Val Tyr Phe Ile Ser Leu 
225                 230                 235                 240 


Asn Val Thr Lys Glu Arg Lys Lys Ser Lys Asn Leu Met Lys Met Met 
                245                 250                 255     


Gly Leu Gln Asp Ser Ala Phe Trp Leu Ser Trp Gly Leu Ile Tyr Ala 
            260                 265                 270         


Gly Phe Ile Phe Ile Ile Ser Ile Phe Val Thr Ile Ile Ile Thr Phe 
        275                 280                 285             


Thr Gln Ile Ile Val Met Thr Gly Phe Met Val Ile Phe Ile Leu Phe 
    290                 295                 300                 


Phe Leu Tyr Gly Leu Ser Leu Val Ala Leu Val Phe Leu Met Ser Val 
305                 310                 315                 320 


Leu Leu Lys Lys Ala Val Leu Thr Asn Leu Val Val Phe Leu Leu Thr 
                325                 330                 335     


Leu Phe Trp Gly Cys Leu Gly Phe Thr Val Phe Tyr Glu Gln Leu Pro 
            340                 345                 350         


Ser Ser Leu Glu Trp Ile Leu Asn Ile Cys Ser Pro Phe Ala Phe Thr 
        355                 360                 365             


Thr Gly Met Ile Gln Ile Ile Lys Leu Asp Tyr Asn Leu Asn Gly Val 
    370                 375                 380                 


Ile Phe Pro Asp Pro Ser Gly Asp Ser Tyr Thr Met Ile Ala Thr Phe 
385                 390                 395                 400 


Ser Met Leu Leu Leu Asp Gly Leu Ile Tyr Leu Leu Leu Ala Leu Tyr 
                405                 410                 415     


Phe Asp Lys Ile Leu Pro Tyr Gly Asp Glu Arg His Tyr Ser Pro Leu 
            420                 425                 430         


Phe Phe Leu Asn Ser Ser Ser Cys Phe Gln His Gln Arg Thr Asn Ala 
        435                 440                 445             


Lys Val Ile Glu Lys Glu Ile Asp Ala Glu His Pro Ser Asp Asp Tyr 
    450                 455                 460                 


Phe Glu Pro Val Ala Pro Glu Phe Gln Gly Lys Glu Ala Ile Arg Ile 
465                 470                 475                 480 


Arg Asn Val Lys Lys Glu Tyr Lys Gly Lys Ser Gly Lys Val Glu Ala 
                485                 490                 495     


Leu Lys Gly Leu Leu Phe Asp Ile Tyr Glu Gly Gln Ile Thr Ala Ile 
            500                 505                 510         


Leu Gly His Ser Gly Ala Gly Lys Ser Ser Leu Leu Asn Ile Leu Asn 
        515                 520                 525             


Gly Leu Ser Val Pro Thr Glu Gly Ser Val Thr Ile Tyr Asn Lys Asn 
    530                 535                 540                 


Leu Ser Glu Met Gln Asp Leu Glu Glu Ile Arg Lys Ile Thr Gly Val 
545                 550                 555                 560 


Cys Pro Gln Phe Asn Val Gln Phe Asp Ile Leu Thr Val Lys Glu Asn 
                565                 570                 575     


Leu Ser Leu Phe Ala Lys Ile Lys Gly Ile His Leu Lys Glu Val Glu 
            580                 585                 590         


Gln Glu Val Gln Arg Ile Leu Leu Glu Leu Asp Met Gln Asn Ile Gln 
        595                 600                 605             


Asp Asn Leu Ala Lys His Leu Ser Glu Gly Gln Lys Arg Lys Leu Thr 
    610                 615                 620                 


Phe Gly Ile Thr Ile Leu Gly Asp Pro Gln Ile Leu Leu Leu Asp Glu 
625                 630                 635                 640 


Pro Thr Thr Gly Leu Asp Pro Phe Ser Arg Asp Gln Val Trp Ser Leu 
                645                 650                 655     


Leu Arg Glu Arg Arg Ala Asp His Val Ile Leu Phe Ser Thr Gln Ser 
            660                 665                 670         


Met Asp Glu Ala Asp Ile Leu Ala Asp Arg Lys Val Ile Met Ser Asn 
        675                 680                 685             


Gly Arg Leu Lys Cys Ala Gly Ser Ser Met Phe Leu Lys Arg Arg Trp 
    690                 695                 700                 


Gly Leu Gly Tyr His Leu Ser Leu His Arg Asn Glu Ile Cys Asn Pro 
705                 710                 715                 720 


Glu Gln Ile Thr Ser Phe Ile Thr His His Ile Pro Asp Ala Lys Leu 
                725                 730                 735     


Lys Thr Glu Asn Lys Glu Lys Leu Val Tyr Thr Leu Pro Leu Glu Arg 
            740                 745                 750         


Thr Asn Thr Phe Pro Asp Leu Phe Ser Asp Leu Asp Lys Cys Ser Asp 
        755                 760                 765             


Gln Gly Val Thr Gly Tyr Asp Ile Ser Met Ser Thr Leu Asn Glu Val 
    770                 775                 780                 


Phe Met Lys Leu Glu Gly Gln Ser Thr Ile Glu Gln Asp Phe Glu Gln 
785                 790                 795                 800 


Val Glu Met Ile Arg Asp Ser Glu Ser Leu Asn Glu Met Glu Leu Ala 
                805                 810                 815     


His Ser Ser Phe Ser Glu Met Gln Thr Ala Val Ser Asp Met Gly Leu 
            820                 825                 830         


Trp Arg Met Gln Val Phe Ala Met Ala Arg Leu Arg Phe Leu Lys Leu 
        835                 840                 845             


Lys Arg Gln Thr Lys Val Leu Leu Thr Leu Leu Leu Val Phe Gly Ile 
    850                 855                 860                 


Ala Ile Phe Pro Leu Ile Val Glu Asn Ile Met Tyr Ala Met Leu Asn 
865                 870                 875                 880 


Glu Lys Ile Asp Trp Glu Phe Lys Asn Glu Leu Tyr Phe Leu Ser Pro 
                885                 890                 895     


Gly Gln Leu Pro Gln Glu Pro Arg Thr Ser Leu Leu Ile Ile Asn Asn 
            900                 905                 910         


Thr Glu Ser Asn Ile Glu Asp Phe Ile Lys Ser Leu Lys His Gln Asn 
        915                 920                 925             


Ile Leu Leu Glu Val Asp Asp Phe Glu Asn Arg Asn Gly Thr Asp Gly 
    930                 935                 940                 


Leu Ser Tyr Asn Gly Ala Ile Ile Val Ser Gly Lys Gln Lys Asp Tyr 
945                 950                 955                 960 


Arg Phe Ser Val Val Cys Asn Thr Lys Arg Leu His Cys Phe Pro Ile 
                965                 970                 975     


Leu Met Asn Ile Ile Ser Asn Gly Leu Leu Gln Met Phe Asn His Thr 
            980                 985                 990         


Gln His Ile Arg Ile Glu Ser Ser  Pro Phe Pro Leu Ser  His Ile Gly 
        995                 1000                 1005             


Leu Trp  Thr Gly Leu Pro Asp  Gly Ser Phe Phe Leu  Phe Leu Val 
    1010                 1015                 1020             


Leu Cys  Ser Ile Ser Pro Tyr  Ile Thr Met Gly Ser  Ile Ser Asp 
    1025                 1030                 1035             


Tyr Lys  Lys Asn Ala Lys Ser  Gln Leu Trp Ile Ser  Gly Leu Tyr 
    1040                 1045                 1050             


Thr Ser  Ala Tyr Trp Cys Gly  Gln Ala Leu Val Asp  Val Ser Phe 
    1055                 1060                 1065             


Phe Ile  Leu Ile Leu Leu Leu  Met Tyr Leu Ile Phe  Tyr Ile Glu 
    1070                 1075                 1080             


Asn Met  Gln Tyr Leu Leu Ile  Thr Ser Gln Ile Val  Phe Ala Leu 
    1085                 1090                 1095             


Val Ile  Val Thr Pro Gly Tyr  Ala Ala Ser Leu Val  Phe Phe Ile 
    1100                 1105                 1110             


Tyr Met  Ile Ser Phe Ile Phe  Arg Lys Arg Arg Lys  Asn Ser Gly 
    1115                 1120                 1125             


Leu Trp  Ser Phe Tyr Phe Phe  Phe Ala Ser Thr Ile  Met Phe Ser 
    1130                 1135                 1140             


Ile Thr  Leu Ile Asn His Phe  Asp Leu Ser Ile Leu  Ile Thr Thr 
    1145                 1150                 1155             


Met Val  Leu Val Pro Ser Tyr  Thr Leu Leu Gly Phe  Lys Thr Phe 
    1160                 1165                 1170             


Leu Glu  Val Arg Asp Gln Glu  His Tyr Arg Glu Phe  Pro Glu Ala 
    1175                 1180                 1185             


Asn Phe  Glu Leu Ser Ala Thr  Asp Phe Leu Val Cys  Phe Ile Pro 
    1190                 1195                 1200             


Tyr Phe  Gln Thr Leu Leu Phe  Val Phe Val Leu Arg  Cys Met Glu 
    1205                 1210                 1215             


Leu Lys  Cys Gly Lys Lys Arg  Met Arg Lys Asp Pro  Val Phe Arg 
    1220                 1225                 1230             


Ile Ser  Pro Gln Ser Arg Asp  Ala Lys Pro Asn Pro  Glu Glu Pro 
    1235                 1240                 1245             


Ile Asp  Glu Asp Glu Asp Ile  Gln Thr Glu Arg Ile  Arg Thr Ala 
    1250                 1255                 1260             


Thr Ala  Leu Thr Thr Ser Ile  Leu Asp Glu Lys Pro  Val Ile Ile 
    1265                 1270                 1275             


Ala Ser  Cys Leu His Lys Glu  Tyr Ala Gly Gln Lys  Lys Ser Cys 
    1280                 1285                 1290             


Phe Ser  Lys Arg Lys Lys Lys  Ile Ala Ala Arg Asn  Ile Ser Phe 
    1295                 1300                 1305             


Cys Val  Gln Glu Gly Glu Ile  Leu Gly Leu Leu Gly  Pro Asn Gly 
    1310                 1315                 1320             


Ala Gly  Lys Ser Ser Ser Ile  Arg Met Ile Ser Gly  Ile Thr Lys 
    1325                 1330                 1335             


Pro Thr  Ala Gly Glu Val Glu  Leu Lys Gly Cys Ser  Ser Val Leu 
    1340                 1345                 1350             


Gly His  Leu Gly Tyr Cys Pro  Gln Glu Asn Val Leu  Trp Pro Met 
    1355                 1360                 1365             


Leu Thr  Leu Arg Glu His Leu  Glu Val Tyr Ala Ala  Val Lys Gly 
    1370                 1375                 1380             


Leu Arg  Lys Ala Asp Ala Arg  Leu Ala Ile Ala Arg  Leu Val Ser 
    1385                 1390                 1395             


Ala Phe  Lys Leu His Glu Gln  Leu Asn Val Pro Val  Gln Lys Leu 
    1400                 1405                 1410             


Thr Ala  Gly Ile Thr Arg Lys  Leu Cys Phe Val Leu  Ser Leu Leu 
    1415                 1420                 1425             


Gly Asn  Ser Pro Val Leu Leu  Leu Asp Glu Pro Ser  Thr Gly Ile 
    1430                 1435                 1440             


Asp Pro  Thr Gly Gln Gln Gln  Met Trp Gln Ala Ile  Gln Ala Val 
    1445                 1450                 1455             


Val Lys  Asn Thr Glu Arg Gly  Val Leu Leu Thr Thr  His Asn Leu 
    1460                 1465                 1470             


Ala Glu  Ala Glu Ala Leu Cys  Asp Arg Val Ala Ile  Met Val Ser 
    1475                 1480                 1485             


Gly Arg  Leu Arg Cys Ile Gly  Ser Ile Gln His Leu  Lys Asn Lys 
    1490                 1495                 1500             


Leu Gly  Lys Asp Tyr Ile Leu  Glu Leu Lys Val Lys  Glu Thr Ser 
    1505                 1510                 1515             


Gln Val  Thr Leu Val His Thr  Glu Ile Leu Lys Leu  Phe Pro Gln 
    1520                 1525                 1530             


Ala Ala  Gly Gln Glu Arg Tyr  Ser Ser Leu Leu Thr  Tyr Lys Leu 
    1535                 1540                 1545             


Pro Val  Ala Asp Val Tyr Pro  Leu Ser Gln Thr Phe  His Lys Leu 
    1550                 1555                 1560             


Glu Ala  Val Lys His Asn Phe  Asn Leu Glu Glu Tyr  Ser Leu Ser 
    1565                 1570                 1575             


Gln Cys  Thr Leu Glu Lys Val  Phe Leu Glu Leu Ser  Lys Glu Gln 
    1580                 1585                 1590             


Glu Val  Gly Asn Phe Asp Glu  Glu Ile Asp Thr Thr  Met Arg Trp 
    1595                 1600                 1605             


Lys Leu  Leu Pro His Ser Asp  Glu Pro 
    1610                 1615         


<210>  49
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly 
        275                 280                 285             


Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu 
    290                 295                 300                 


Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg 
305                 310                 315                 320 


Arg Lys Arg Lys Arg Met Thr Asp Pro Thr Arg Arg Phe Phe Lys Val 
                325                 330                 335     


Thr Pro Pro Pro Gly Ser Gly Pro Gln Asn Gln Tyr Gly Asn Val Leu 
            340                 345                 350         


Ser Leu Pro Thr Pro Thr Ser Gly Leu Gly Arg Ala Gln Arg Trp Ala 
        355                 360                 365             


Ala Gly Leu Gly Gly Thr Ala Pro Ser Tyr Gly Asn Pro Ser Ser Asp 
    370                 375                 380                 


Val Gln Ala Asp Gly Ala Leu Gly Ser Arg Ser Pro Pro Gly Val Gly 
385                 390                 395                 400 


Pro Glu Glu Glu Glu Gly Glu Gly Tyr Glu Glu Pro Asp Ser Glu Glu 
                405                 410                 415     


Asp Ser Glu Phe Tyr Glu Asn Asp Ser Asn Leu Gly Gln Asp Gln Leu 
            420                 425                 430         


Ser Gln Asp Gly Ser Gly Tyr Glu Asn Pro Glu Asp Glu Pro Leu Gly 
        435                 440                 445             


Pro Glu Asp Glu Asp Ser Phe Ser Asn Ala Glu Ser Tyr Glu Asn Glu 
    450                 455                 460                 


Asp Glu Glu Leu Thr Gln Pro Val Ala Arg Thr Met Asp Phe Leu Ser 
465                 470                 475                 480 


Pro His Gly Ser Ala Trp Asp Pro Ser Arg Glu Ala Thr Ser Leu Gly 
                485                 490                 495     


Ser Gln Ser Tyr Glu Asp Met Arg Gly Ile Leu Tyr Ala Ala Pro Gln 
            500                 505                 510         


Leu Arg Ser Ile Arg Gly Gln Pro Gly Pro Asn His Glu Glu Asp Ala 
        515                 520                 525             


Asp Ser Tyr Glu Asn Met Asp Asn Pro Asp Gly Pro Asp Pro Ala Trp 
    530                 535                 540                 


Gly Gly Gly Gly Arg Met Gly Thr Trp Ser Thr Arg 
545                 550                 555     


<210>  50
<211>  1577
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Glu Ala Gly Ser Val Val Arg Ala Ile Phe Asp Phe Cys Pro Ser 
1               5                   10                  15      


Val Ser Glu Glu Leu Pro Leu Phe Val Gly Asp Ile Ile Glu Val Leu 
            20                  25                  30          


Ala Val Val Asp Glu Phe Trp Leu Leu Gly Lys Lys Glu Asp Val Thr 
        35                  40                  45              


Gly Gln Phe Pro Ser Ser Phe Val Glu Ile Val Thr Ile Pro Ser Leu 
    50                  55                  60                  


Lys Glu Gly Glu Arg Leu Phe Val Cys Ile Cys Glu Phe Thr Ser Gln 
65                  70                  75                  80  


Glu Leu Asp Asn Leu Pro Leu His Arg Gly Asp Leu Val Ile Leu Asp 
                85                  90                  95      


Gly Ile Pro Thr Ala Gly Trp Leu Gln Gly Arg Ser Cys Trp Gly Ala 
            100                 105                 110         


Arg Gly Phe Phe Pro Ser Ser Cys Val Arg Glu Leu Cys Leu Ser Ser 
        115                 120                 125             


Gln Ser Arg Gln Trp His Ser Gln Ser Ala Leu Phe Gln Ile Pro Glu 
    130                 135                 140                 


Tyr Ser Met Gly Gln Ala Arg Ala Leu Met Gly Leu Ser Ala Gln Leu 
145                 150                 155                 160 


Asp Glu Glu Leu Asp Phe Arg Glu Gly Asp Val Ile Thr Ile Ile Gly 
                165                 170                 175     


Val Pro Glu Pro Gly Trp Phe Glu Gly Glu Leu Glu Gly Arg Arg Gly 
            180                 185                 190         


Ile Phe Pro Glu Gly Phe Val Glu Leu Leu Gly Pro Leu Arg Thr Val 
        195                 200                 205             


Asp Glu Ser Val Ser Ser Gly Asn Gln Asp Asp Cys Ile Val Asn Gly 
    210                 215                 220                 


Glu Val Asp Thr Pro Val Gly Glu Glu Glu Ile Gly Pro Asp Glu Asp 
225                 230                 235                 240 


Glu Glu Glu Pro Gly Thr Tyr Gly Val Ala Leu Tyr Arg Phe Gln Ala 
                245                 250                 255     


Leu Glu Pro Asn Glu Leu Asp Phe Glu Val Gly Asp Lys Ile Arg Ile 
            260                 265                 270         


Leu Ala Thr Leu Glu Asp Gly Trp Leu Glu Gly Ser Leu Lys Gly Arg 
        275                 280                 285             


Thr Gly Ile Phe Pro Tyr Arg Phe Val Lys Leu Cys Pro Asp Thr Arg 
    290                 295                 300                 


Val Glu Glu Thr Met Ala Leu Pro Gln Glu Gly Ser Leu Ala Arg Ile 
305                 310                 315                 320 


Pro Glu Thr Ser Leu Asp Cys Leu Glu Asn Thr Leu Gly Val Glu Glu 
                325                 330                 335     


Gln Arg His Glu Thr Ser Asp His Glu Ala Glu Glu Pro Asp Cys Ile 
            340                 345                 350         


Ile Ser Glu Ala Pro Thr Ser Pro Leu Gly His Leu Thr Ser Glu Tyr 
        355                 360                 365             


Asp Thr Asp Arg Asn Ser Tyr Gln Asp Glu Asp Thr Ala Gly Gly Pro 
    370                 375                 380                 


Pro Arg Ser Pro Gly Val Glu Trp Glu Met Pro Leu Ala Thr Asp Ser 
385                 390                 395                 400 


Pro Thr Ser Asp Pro Thr Glu Val Val Asn Gly Ile Ser Ser Gln Pro 
                405                 410                 415     


Gln Val Pro Phe His Pro Asn Leu Gln Lys Ser Gln Tyr Tyr Ser Thr 
            420                 425                 430         


Val Gly Gly Ser His Pro His Ser Glu Gln Tyr Pro Asp Leu Leu Pro 
        435                 440                 445             


Leu Glu Ala Arg Thr Arg Asp Tyr Ala Ser Leu Pro Pro Lys Arg Met 
    450                 455                 460                 


Tyr Ser Gln Leu Lys Thr Leu Gln Lys Pro Val Leu Pro Leu Tyr Arg 
465                 470                 475                 480 


Gly Ser Ser Val Ser Ala Ser Arg Val Val Lys Pro Arg Gln Ser Ser 
                485                 490                 495     


Pro Gln Leu His Asn Leu Ala Ser Tyr Thr Lys Lys His His Thr Ser 
            500                 505                 510         


Ser Val Tyr Ser Ile Ser Glu Arg Leu Glu Met Lys Pro Gly Pro Gln 
        515                 520                 525             


Ala Gln Gly Leu Val Met Glu Ala Ala Thr His Ser Gln Gly Asp Gly 
    530                 535                 540                 


Ser Thr Asp Leu Asp Ser Lys Leu Thr Gln Gln Leu Ile Glu Phe Glu 
545                 550                 555                 560 


Lys Ser Leu Ala Gly Pro Gly Thr Glu Pro Asp Lys Ile Leu Arg His 
                565                 570                 575     


Phe Ser Ile Met Asp Phe Asn Ser Glu Lys Asp Ile Val Arg Gly Ser 
            580                 585                 590         


Ser Lys Leu Ile Thr Glu Gln Glu Leu Pro Glu Arg Arg Lys Ala Leu 
        595                 600                 605             


Arg Pro Pro Pro Pro Arg Pro Cys Thr Pro Val Ser Thr Ser Pro His 
    610                 615                 620                 


Leu Leu Val Asp Gln Asn Leu Lys Pro Ala Pro Pro Leu Val Val Arg 
625                 630                 635                 640 


Pro Ser Arg Pro Ala Pro Leu Pro Pro Ser Ala Gln Gln Arg Thr Asn 
                645                 650                 655     


Ala Val Ser Pro Lys Leu Leu Ser Arg His Arg Pro Thr Cys Glu Thr 
            660                 665                 670         


Leu Glu Lys Glu Gly Pro Gly His Met Gly Arg Ser Leu Asp Gln Thr 
        675                 680                 685             


Ser Pro Cys Pro Leu Val Leu Val Arg Ile Glu Glu Met Glu Arg Asp 
    690                 695                 700                 


Leu Asp Met Tyr Ser Arg Ala Gln Glu Glu Leu Asn Leu Met Leu Glu 
705                 710                 715                 720 


Glu Lys Gln Asp Glu Ser Ser Arg Ala Glu Thr Leu Glu Asp Leu Lys 
                725                 730                 735     


Phe Cys Glu Ser Asn Ile Glu Ser Leu Asn Met Glu Leu Gln Gln Leu 
            740                 745                 750         


Arg Glu Met Thr Leu Leu Ser Ser Gln Ser Ser Ser Leu Val Ala Pro 
        755                 760                 765             


Ser Gly Ser Val Ser Ala Glu Asn Pro Glu Gln Arg Met Leu Glu Lys 
    770                 775                 780                 


Arg Ala Lys Val Ile Glu Glu Leu Leu Gln Thr Glu Arg Asp Tyr Ile 
785                 790                 795                 800 


Arg Asp Leu Glu Met Cys Ile Glu Arg Ile Met Val Pro Met Gln Gln 
                805                 810                 815     


Ala Gln Val Pro Asn Ile Asp Phe Glu Gly Leu Phe Gly Asn Met Gln 
            820                 825                 830         


Met Val Ile Lys Val Ser Lys Gln Leu Leu Ala Ala Leu Glu Ile Ser 
        835                 840                 845             


Asp Ala Val Gly Pro Val Phe Leu Gly His Arg Asp Glu Leu Glu Gly 
    850                 855                 860                 


Thr Tyr Lys Ile Tyr Cys Gln Asn His Asp Glu Ala Ile Ala Leu Leu 
865                 870                 875                 880 


Glu Ile Tyr Glu Lys Asp Glu Lys Ile Gln Lys His Leu Gln Asp Ser 
                885                 890                 895     


Leu Ala Asp Leu Lys Ser Leu Tyr Asn Glu Trp Gly Cys Thr Asn Tyr 
            900                 905                 910         


Ile Asn Leu Gly Ser Phe Leu Ile Lys Pro Val Gln Arg Val Met Arg 
        915                 920                 925             


Tyr Pro Leu Leu Leu Met Glu Leu Leu Asn Ser Thr Pro Glu Ser His 
    930                 935                 940                 


Pro Asp Lys Val Pro Leu Thr Asn Ala Val Leu Ala Val Lys Glu Ile 
945                 950                 955                 960 


Asn Val Asn Ile Asn Glu Tyr Lys Arg Arg Lys Asp Leu Val Leu Lys 
                965                 970                 975     


Tyr Arg Lys Gly Asp Glu Asp Ser Leu Met Glu Lys Ile Ser Lys Leu 
            980                 985                 990         


Asn Ile His Ser Ile Ile Lys Lys  Ser Asn Arg Val Ser  Ser His Leu 
        995                 1000                 1005             


Lys His  Leu Thr Gly Phe Ala  Pro Gln Ile Lys Asp  Glu Val Phe 
    1010                 1015                 1020             


Glu Glu  Thr Glu Lys Asn Phe  Arg Met Gln Glu Arg  Leu Ile Lys 
    1025                 1030                 1035             


Ser Phe  Ile Arg Asp Leu Ser  Leu Tyr Leu Gln His  Ile Arg Glu 
    1040                 1045                 1050             


Ser Ala  Cys Val Lys Val Val  Ala Ala Val Ser Met  Trp Asp Val 
    1055                 1060                 1065             


Cys Met  Glu Arg Gly His Arg  Asp Leu Glu Gln Phe  Glu Arg Val 
    1070                 1075                 1080             


His Arg  Tyr Ile Ser Asp Gln  Leu Phe Thr Asn Phe  Lys Glu Arg 
    1085                 1090                 1095             


Thr Glu  Arg Leu Val Ile Ser  Pro Leu Asn Gln Leu  Leu Ser Met 
    1100                 1105                 1110             


Phe Thr  Gly Pro His Lys Leu  Val Gln Lys Arg Phe  Asp Lys Leu 
    1115                 1120                 1125             


Leu Asp  Phe Tyr Asn Cys Thr  Glu Arg Ala Glu Lys  Leu Lys Asp 
    1130                 1135                 1140             


Lys Lys  Thr Leu Glu Glu Leu  Gln Ser Ala Arg Asn  Asn Tyr Glu 
    1145                 1150                 1155             


Ala Leu  Asn Ala Gln Leu Leu  Asp Glu Leu Pro Lys  Phe His Gln 
    1160                 1165                 1170             


Tyr Ala  Gln Gly Leu Phe Thr  Asn Cys Val His Gly  Tyr Ala Glu 
    1175                 1180                 1185             


Ala His  Cys Asp Phe Val His  Gln Ala Leu Glu Gln  Leu Lys Pro 
    1190                 1195                 1200             


Leu Leu  Ser Leu Leu Lys Val  Ala Gly Arg Glu Gly  Asn Leu Ile 
    1205                 1210                 1215             


Ala Ile  Phe His Glu Glu His  Ser Arg Val Leu Gln  Gln Leu Gln 
    1220                 1225                 1230             


Val Phe  Thr Phe Phe Pro Glu  Ser Leu Pro Ala Thr  Lys Lys Pro 
    1235                 1240                 1245             


Phe Glu  Arg Lys Thr Ile Asp  Arg Gln Ser Ala Arg  Lys Pro Leu 
    1250                 1255                 1260             


Leu Gly  Leu Pro Ser Tyr Met  Leu Gln Ser Glu Glu  Leu Arg Ala 
    1265                 1270                 1275             


Ser Leu  Leu Ala Arg Tyr Pro  Pro Glu Lys Leu Phe  Gln Ala Glu 
    1280                 1285                 1290             


Arg Asn  Phe Asn Ala Ala Gln  Asp Leu Asp Val Ser  Leu Leu Glu 
    1295                 1300                 1305             


Gly Asp  Leu Val Gly Val Ile  Lys Lys Lys Asp Pro  Met Gly Ser 
    1310                 1315                 1320             


Gln Asn  Arg Trp Leu Ile Asp  Asn Gly Val Thr Lys  Gly Phe Val 
    1325                 1330                 1335             


Tyr Ser  Ser Phe Leu Lys Pro  Tyr Asn Pro Arg Arg  Ser His Ser 
    1340                 1345                 1350             


Asp Ala  Ser Val Gly Ser His  Ser Ser Thr Glu Ser  Glu His Gly 
    1355                 1360                 1365             


Ser Ser  Ser Pro Arg Phe Pro  Arg Gln Asn Ser Gly  Ser Thr Leu 
    1370                 1375                 1380             


Thr Phe  Asn Pro Ser Ser Met  Ala Val Ser Phe Thr  Ser Gly Ser 
    1385                 1390                 1395             


Cys Gln  Lys Gln Pro Gln Asp  Ala Ser Pro Pro Pro  Lys Glu Cys 
    1400                 1405                 1410             


Asp Gln  Gly Thr Leu Ser Ala  Ser Leu Asn Pro Ser  Asn Ser Glu 
    1415                 1420                 1425             


Ser Ser  Pro Ser Arg Cys Pro  Ser Asp Pro Asp Ser  Thr Ser Gln 
    1430                 1435                 1440             


Pro Arg  Ser Gly Asp Ser Ala  Asp Val Ala Arg Asp  Val Lys Gln 
    1445                 1450                 1455             


Pro Thr  Ala Thr Pro Arg Ser  Tyr Arg Asn Phe Arg  His Pro Glu 
    1460                 1465                 1470             


Ile Val  Gly Tyr Ser Val Pro  Gly Arg Asn Gly Gln  Ser Gln Asp 
    1475                 1480                 1485             


Leu Val  Lys Gly Cys Ala Arg  Thr Ala Gln Ala Pro  Glu Asp Arg 
    1490                 1495                 1500             


Ser Thr  Glu Pro Asp Gly Ser  Glu Ala Glu Gly Asn  Gln Val Tyr 
    1505                 1510                 1515             


Phe Ala  Val Tyr Thr Phe Lys  Ala Arg Asn Pro Asn  Glu Leu Ser 
    1520                 1525                 1530             


Val Ser  Ala Asn Gln Lys Leu  Lys Ile Leu Glu Phe  Lys Asp Val 
    1535                 1540                 1545             


Thr Gly  Asn Thr Glu Trp Trp  Leu Ala Glu Val Asn  Gly Lys Lys 
    1550                 1555                 1560             


Gly Tyr  Val Pro Ser Asn Tyr  Ile Arg Lys Thr Glu  Tyr Thr 
    1565                 1570                 1575         


<210>  51
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Trp Ala Thr Leu Pro Leu Leu Cys Ala Gly Ala Trp Leu Leu Gly 
1               5                   10                  15      


Val Pro Val Cys Gly Ala Ala Glu Leu Cys Val Asn Ser Leu Glu Lys 
            20                  25                  30          


Phe His Phe Lys Ser Trp Met Ser Lys His Arg Lys Thr Tyr Ser Thr 
        35                  40                  45              


Glu Glu Tyr His His Arg Leu Gln Thr Phe Ala Ser Asn Trp Arg Lys 
    50                  55                  60                  


Ile Asn Ala His Asn Asn Gly Asn His Thr Phe Lys Met Ala Leu Asn 
65                  70                  75                  80  


Gln Phe Ser Asp Met Ser Phe Ala Glu Ile Lys His Lys Tyr Leu Trp 
                85                  90                  95      


Ser Glu Pro Gln Asn Cys Ser Ala Thr Lys Ser Asn Tyr Leu Arg Gly 
            100                 105                 110         


Thr Gly Pro Tyr Pro Pro Ser Val Asp Trp Arg Lys Lys Gly Asn Phe 
        115                 120                 125             


Val Ser Pro Val Lys Asn Gln Gly Ala Cys Gly Ser Cys Trp Thr Phe 
    130                 135                 140                 


Ser Thr Thr Gly Ala Leu Glu Ser Ala Ile Ala Ile Ala Thr Gly Lys 
145                 150                 155                 160 


Met Leu Ser Leu Ala Glu Gln Gln Leu Val Asp Cys Ala Gln Asp Phe 
                165                 170                 175     


Asn Asn His Gly Cys Gln Gly Gly Leu Pro Ser Gln Ala Phe Glu Tyr 
            180                 185                 190         


Ile Leu Tyr Asn Lys Gly Ile Met Gly Glu Asp Thr Tyr Pro Tyr Gln 
        195                 200                 205             


Gly Lys Asp Gly Tyr Cys Lys Phe Gln Pro Gly Lys Ala Ile Gly Phe 
    210                 215                 220                 


Val Lys Asp Val Ala Asn Ile Thr Ile Tyr Asp Glu Glu Ala Met Val 
225                 230                 235                 240 


Glu Ala Val Ala Leu Tyr Asn Pro Val Ser Phe Ala Phe Glu Val Thr 
                245                 250                 255     


Gln Asp Phe Met Met Tyr Arg Thr Gly Ile Tyr Ser Ser Thr Ser Cys 
            260                 265                 270         


His Lys Thr Pro Asp Lys Val Asn His Ala Val Leu Ala Val Gly Tyr 
        275                 280                 285             


Gly Glu Lys Asn Gly Ile Pro Tyr Trp Ile Val Lys Asn Ser Trp Gly 
    290                 295                 300                 


Pro Gln Trp Gly Met Asn Gly Tyr Phe Leu Ile Glu Arg Gly Lys Asn 
305                 310                 315                 320 


Met Cys Gly Leu Ala Ala Cys Ala Ser Tyr Pro Ile Pro Leu Val 
                325                 330                 335 


<210>  52
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu 
1               5                   10                  15      


Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp 
            20                  25                  30          


Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Ala 
        35                  40                  45              


Asp Asn Asn Thr Lys Ala Asn Val Thr Lys Pro Lys Arg Cys Ser Gly 
    50                  55                  60                  


Ser Ile Cys Tyr Gly Thr Ile Ala Val Ile Val Phe Phe Leu Ile Gly 
65                  70                  75                  80  


Phe Met Ile Gly Tyr Leu Gly Tyr Cys Lys Gly Val Glu Pro Lys Thr 
                85                  90                  95      


Glu Cys Glu Arg Leu Ala Gly Thr Glu Ser Pro Val Arg Glu Glu Pro 
            100                 105                 110         


Gly Glu Asp Phe Pro Ala Ala Arg Arg Leu Tyr Trp Asp Asp Leu Lys 
        115                 120                 125             


Arg Lys Leu Ser Glu Lys Leu Asp Ser Thr Asp Phe Thr Gly Thr Ile 
    130                 135                 140                 


Lys Leu Leu Asn Glu Asn Ser Tyr Val Pro Arg Glu Ala Gly Ser Gln 
145                 150                 155                 160 


Lys Asp Glu Asn Leu Ala Leu Tyr Val Glu Asn Gln Phe Arg Glu Phe 
                165                 170                 175     


Lys Leu Ser Lys Val Trp Arg Asp Gln His Phe Val Lys Ile Gln Val 
            180                 185                 190         


Lys Asp Ser Ala Gln Asn Ser Val Ile Ile Val Asp Lys Asn Gly Arg 
        195                 200                 205             


Leu Val Tyr Leu Val Glu Asn Pro Gly Gly Tyr Val Ala Tyr Ser Lys 
    210                 215                 220                 


Ala Ala Thr Val Thr Gly Lys Leu Val His Ala Asn Phe Gly Thr Lys 
225                 230                 235                 240 


Lys Asp Phe Glu Asp Leu Tyr Thr Pro Val Asn Gly Ser Ile Val Ile 
                245                 250                 255     


Val Arg Ala Gly Lys Ile Thr Phe Ala Glu Lys Val Ala Asn Ala Glu 
            260                 265                 270         


Ser Leu Asn Ala Ile Gly Val Leu Ile Tyr Met Asp Gln Thr Lys Phe 
        275                 280                 285             


Pro Ile Val Asn Ala Glu Leu Ser Phe Phe Gly His Ala His Leu Gly 
    290                 295                 300                 


Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn His Thr Gln 
305                 310                 315                 320 


Phe Pro Pro Ser Arg Ser Ser Gly Leu Pro Asn Ile Pro Val Gln Thr 
                325                 330                 335     


Ile Ser Arg Ala Ala Ala Glu Lys Leu Phe Gly Asn Met Glu Gly Asp 
            340                 345                 350         


Cys Pro Ser Asp Trp Lys Thr Asp Ser Thr Cys Arg Met Val Thr Ser 
        355                 360                 365             


Glu Ser Lys Asn Val Lys Leu Thr Val Ser Asn Val Leu Lys Glu Ile 
    370                 375                 380                 


Lys Ile Leu Asn Ile Phe Gly Val Ile Lys Gly Phe Val Glu Pro Asp 
385                 390                 395                 400 


His Tyr Val Val Val Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala 
                405                 410                 415     


Ala Lys Ser Gly Val Gly Thr Ala Leu Leu Leu Lys Leu Ala Gln Met 
            420                 425                 430         


Phe Ser Asp Met Val Leu Lys Asp Gly Phe Gln Pro Ser Arg Ser Ile 
        435                 440                 445             


Ile Phe Ala Ser Trp Ser Ala Gly Asp Phe Gly Ser Val Gly Ala Thr 
    450                 455                 460                 


Glu Trp Leu Glu Gly Tyr Leu Ser Ser Leu His Leu Lys Ala Phe Thr 
465                 470                 475                 480 


Tyr Ile Asn Leu Asp Lys Ala Val Leu Gly Thr Ser Asn Phe Lys Val 
                485                 490                 495     


Ser Ala Ser Pro Leu Leu Tyr Thr Leu Ile Glu Lys Thr Met Gln Asn 
            500                 505                 510         


Val Lys His Pro Val Thr Gly Gln Phe Leu Tyr Gln Asp Ser Asn Trp 
        515                 520                 525             


Ala Ser Lys Val Glu Lys Leu Thr Leu Asp Asn Ala Ala Phe Pro Phe 
    530                 535                 540                 


Leu Ala Tyr Ser Gly Ile Pro Ala Val Ser Phe Cys Phe Cys Glu Asp 
545                 550                 555                 560 


Thr Asp Tyr Pro Tyr Leu Gly Thr Thr Met Asp Thr Tyr Lys Glu Leu 
                565                 570                 575     


Ile Glu Arg Ile Pro Glu Leu Asn Lys Val Ala Arg Ala Ala Ala Glu 
            580                 585                 590         


Val Ala Gly Gln Phe Val Ile Lys Leu Thr His Asp Val Glu Leu Asn 
        595                 600                 605             


Leu Asp Tyr Glu Arg Tyr Asn Ser Gln Leu Leu Ser Phe Val Arg Asp 
    610                 615                 620                 


Leu Asn Gln Tyr Arg Ala Asp Ile Lys Glu Met Gly Leu Ser Leu Gln 
625                 630                 635                 640 


Trp Leu Tyr Ser Ala Arg Gly Asp Phe Phe Arg Ala Thr Ser Arg Leu 
                645                 650                 655     


Thr Thr Asp Phe Gly Asn Ala Glu Lys Thr Asp Arg Phe Val Met Lys 
            660                 665                 670         


Lys Leu Asn Asp Arg Val Met Arg Val Glu Tyr His Phe Leu Ser Pro 
        675                 680                 685             


Tyr Val Ser Pro Lys Glu Ser Pro Phe Arg His Val Phe Trp Gly Ser 
    690                 695                 700                 


Gly Ser His Thr Leu Pro Ala Leu Leu Glu Asn Leu Lys Leu Arg Lys 
705                 710                 715                 720 


Gln Asn Asn Gly Ala Phe Asn Glu Thr Leu Phe Arg Asn Gln Leu Ala 
                725                 730                 735     


Leu Ala Thr Trp Thr Ile Gln Gly Ala Ala Asn Ala Leu Ser Gly Asp 
            740                 745                 750         


Val Trp Asp Ile Asp Asn Glu Phe 
        755                 760 


<210>  53
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Ala Gly Val Gly Ala Gly Pro Leu Arg Ala Met Gly Arg Gln Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ala Leu Cys Ala Thr Gly Ala Gln Gly Leu Tyr Phe 
            20                  25                  30          


His Ile Gly Glu Thr Glu Lys Arg Cys Phe Ile Glu Glu Ile Pro Asp 
        35                  40                  45              


Glu Thr Met Val Ile Gly Asn Tyr Arg Thr Gln Met Trp Asp Lys Gln 
    50                  55                  60                  


Lys Glu Val Phe Leu Pro Ser Thr Pro Gly Leu Gly Met His Val Glu 
65                  70                  75                  80  


Val Lys Asp Pro Asp Gly Lys Val Val Leu Ser Arg Gln Tyr Gly Ser 
                85                  90                  95      


Glu Gly Arg Phe Thr Phe Thr Ser His Thr Pro Gly Asp His Gln Ile 
            100                 105                 110         


Cys Leu His Ser Asn Ser Thr Arg Met Ala Leu Phe Ala Gly Gly Lys 
        115                 120                 125             


Leu Arg Val His Leu Asp Ile Gln Val Gly Glu His Ala Asn Asn Tyr 
    130                 135                 140                 


Pro Glu Ile Ala Ala Lys Asp Lys Leu Thr Glu Leu Gln Leu Arg Ala 
145                 150                 155                 160 


Arg Gln Leu Leu Asp Gln Val Glu Gln Ile Gln Lys Glu Gln Asp Tyr 
                165                 170                 175     


Gln Arg Tyr Arg Glu Glu Arg Phe Arg Leu Thr Ser Glu Ser Thr Asn 
            180                 185                 190         


Gln Arg Val Leu Trp Trp Ser Ile Ala Gln Thr Val Ile Leu Ile Leu 
        195                 200                 205             


Thr Gly Ile Trp Gln Met Arg His Leu Lys Ser Phe Phe Glu Ala Lys 
    210                 215                 220                 


Lys Leu Val 
225         


<210>  54
<211>  287
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Tyr Cys Asp Asn Arg Asn Leu Lys Tyr Leu Pro Phe Val Pro Ser 
1               5                   10                  15      


Arg Met Lys Tyr Val Tyr Phe Gln Asn Asn Gln Ile Thr Ser Ile Gln 
            20                  25                  30          


Glu Gly Val Phe Asp Asn Ala Thr Gly Leu Leu Trp Ile Ala Leu His 
        35                  40                  45              


Gly Asn Gln Ile Thr Ser Asp Lys Val Gly Arg Lys Val Phe Ser Lys 
    50                  55                  60                  


Leu Arg His Leu Glu Arg Leu Tyr Leu Asp His Asn Asn Leu Thr Arg 
65                  70                  75                  80  


Met Pro Gly Pro Leu Pro Arg Ser Leu Arg Glu Leu His Leu Asp His 
                85                  90                  95      


Asn Gln Ile Ser Arg Val Pro Asn Asn Ala Leu Glu Gly Leu Glu Asn 
            100                 105                 110         


Leu Thr Ala Leu Tyr Leu Gln His Asn Glu Ile Gln Glu Val Gly Ser 
        115                 120                 125             


Ser Met Arg Gly Leu Arg Ser Leu Ile Leu Leu Asp Leu Ser Tyr Asn 
    130                 135                 140                 


His Leu Arg Lys Val Pro Asp Gly Leu Pro Ser Ala Leu Glu Gln Leu 
145                 150                 155                 160 


Tyr Met Glu His Asn Asn Val Tyr Thr Val Pro Asp Ser Tyr Phe Arg 
                165                 170                 175     


Gly Ala Pro Lys Leu Leu Tyr Val Arg Leu Ser His Asn Ser Leu Thr 
            180                 185                 190         


Asn Asn Gly Leu Ala Ser Asn Thr Phe Asn Ser Ser Ser Leu Leu Glu 
        195                 200                 205             


Leu Asp Leu Ser Tyr Asn Gln Leu Gln Lys Ile Pro Pro Val Asn Thr 
    210                 215                 220                 


Asn Leu Glu Asn Leu Tyr Leu Gln Gly Asn Arg Ile Asn Glu Phe Ser 
225                 230                 235                 240 


Ile Ser Ser Phe Cys Thr Val Val Asp Val Val Asn Phe Ser Lys Leu 
                245                 250                 255     


Gln Val Leu Arg Leu Asp Gly Asn Glu Ile Lys Arg Ser Ala Met Pro 
            260                 265                 270         


Ala Asp Ala Pro Leu Cys Leu Arg Leu Ala Ser Leu Ile Glu Ile 
        275                 280                 285         


<210>  55
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Pro Ala Glu Pro 
1               5                   10                  15      


Met Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg 
            20                  25                  30          


Arg Met Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu 
        35                  40                  45              


Ser Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile 
    50                  55                  60                  


Ala Leu Gly Gly Leu Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile 
65                  70                  75                  80  


Cys Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile 
                85                  90                  95      


Ser Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu 
            100                 105                 110         


Val Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile 
        115                 120                 125             


Ser Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser 
    130                 135                 140                 


His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro 
145                 150                 155                 160 


Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn 
                165                 170                 175     


Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly 
            180                 185                 190         


Ile Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile 
        195                 200                 205             


Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys 
    210                 215                 220                 


Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile 
225                 230                 235                 240 


Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro 
                245                 250                 255     


Lys Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu 
            260                 265                 270         


Glu Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser 
        275                 280                 285             


Ser Pro Ile Glu Asn Asp Ser Ser Pro 
    290                 295         


<210>  56
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Ala Lys Pro Glu Gln Ala Ala Asp Gly Gly Val Arg Gly Arg Gly 
1               5                   10                  15      


Ala Arg Pro Pro Ala Gln Glu Ala Gln Arg Arg Arg Arg His Pro Val 
            20                  25                  30          


Val Val Ala Arg Asp Leu Ala Pro Gly Val Pro Gly Ser Leu His Ser 
        35                  40                  45              


Thr Gln Lys Asn Met Ala Gln Glu Thr Asn Gln Thr Pro Gly Pro Met 
    50                  55                  60                  


Leu Cys Ser Thr Gly Cys Gly Phe Tyr Gly Asn Pro Arg Thr Asn Gly 
65                  70                  75                  80  


Met Cys Ser Val Cys Tyr Lys Glu His Leu Gln Arg Gln Gln Asn Ser 
                85                  90                  95      


Gly Arg Met Ser Pro Met Gly Thr Ala Ser Gly Ser Asn Ser Pro Thr 
            100                 105                 110         


Ser Asp Ser Ala Ser Val Gln Arg Ala Asp Thr Ser Leu Asn Asn Cys 
        115                 120                 125             


Glu Gly Ala Ala Gly Ser Thr Ser Glu Lys Ser Arg Asn Val Pro Val 
    130                 135                 140                 


Ala Ala Leu Pro Val Thr Gln Gln Met Thr Glu Met Ser Ile Ser Arg 
145                 150                 155                 160 


Glu Asp Lys Ile Thr Thr Pro Lys Thr Glu Val Ser Glu Pro Val Val 
                165                 170                 175     


Thr Gln Pro Ser Pro Ser Val Ser Gln Pro Ser Thr Ser Gln Ser Glu 
            180                 185                 190         


Glu Lys Ala Pro Glu Leu Pro Lys Pro Lys Lys Asn Arg Cys Phe Met 
        195                 200                 205             


Cys Arg Lys 
    210     


<210>  57
<211>  706
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Lys Ile Phe Ser Glu Ser His Lys Thr Val Phe Val Val Asp His 
1               5                   10                  15      


Cys Pro Tyr Met Ala Glu Ser Cys Arg Gln His Val Glu Phe Asp Met 
            20                  25                  30          


Leu Val Lys Asn Arg Thr Gln Gly Ile Ile Pro Leu Ala Pro Ile Ser 
        35                  40                  45              


Lys Ser Leu Trp Thr Cys Ser Val Glu Ser Ser Met Glu Tyr Cys Arg 
    50                  55                  60                  


Ile Met Tyr Asp Ile Phe Pro Phe Lys Lys Leu Val Asn Phe Ile Val 
65                  70                  75                  80  


Ser Asp Ser Gly Ala His Val Leu Asn Ser Trp Thr Gln Glu Asp Gln 
                85                  90                  95      


Asn Leu Gln Glu Leu Met Ala Ala Leu Ala Ala Val Gly Pro Pro Asn 
            100                 105                 110         


Pro Arg Ala Asp Pro Glu Cys Cys Ser Ile Leu His Gly Leu Val Ala 
        115                 120                 125             


Ala Val Glu Thr Leu Cys Lys Ile Thr Glu Tyr Gln His Glu Ala Arg 
    130                 135                 140                 


Thr Leu Leu Met Glu Asn Ala Glu Arg Val Gly Asn Arg Gly Arg Ile 
145                 150                 155                 160 


Ile Cys Ile Thr Asn Ala Lys Ser Asp Ser His Val Arg Met Leu Glu 
                165                 170                 175     


Asp Cys Val Gln Glu Thr Ile His Glu His Asn Lys Leu Ala Ala Asn 
            180                 185                 190         


Ser Asp His Leu Met Gln Ile Gln Lys Cys Glu Leu Val Leu Ile His 
        195                 200                 205             


Thr Tyr Pro Val Gly Glu Asp Ser Leu Val Ser Asp Arg Ser Lys Lys 
    210                 215                 220                 


Glu Leu Ser Pro Val Leu Thr Ser Glu Val His Ser Val Arg Ala Gly 
225                 230                 235                 240 


Arg His Leu Ala Thr Lys Leu Asn Ile Leu Val Gln Gln His Phe Asp 
                245                 250                 255     


Leu Ala Ser Thr Thr Ile Thr Asn Ile Pro Met Lys Glu Glu Gln His 
            260                 265                 270         


Ala Asn Thr Ser Ala Asn Tyr Asp Val Glu Leu Leu His His Lys Asp 
        275                 280                 285             


Ala His Val Asp Phe Leu Lys Ser Gly Asp Ser His Leu Gly Gly Gly 
    290                 295                 300                 


Ser Arg Glu Gly Ser Phe Lys Glu Thr Ile Thr Leu Lys Trp Cys Thr 
305                 310                 315                 320 


Pro Arg Thr Asn Asn Ile Glu Leu His Tyr Cys Thr Gly Ala Tyr Arg 
                325                 330                 335     


Ile Ser Pro Val Asp Val Asn Ser Arg Pro Ser Ser Cys Leu Thr Asn 
            340                 345                 350         


Phe Leu Leu Asn Gly Arg Ser Val Leu Leu Glu Gln Pro Arg Lys Ser 
        355                 360                 365             


Gly Ser Lys Val Ile Ser His Met Leu Ser Ser His Gly Gly Glu Ile 
    370                 375                 380                 


Phe Leu His Val Leu Ser Ser Ser Arg Ser Ile Leu Glu Asp Pro Pro 
385                 390                 395                 400 


Ser Ile Ser Glu Gly Cys Gly Gly Arg Val Thr Asp Tyr Arg Ile Thr 
                405                 410                 415     


Asp Phe Gly Glu Phe Met Arg Glu Asn Arg Leu Thr Pro Phe Leu Asp 
            420                 425                 430         


Pro Arg Tyr Lys Ile Asp Gly Ser Leu Glu Val Pro Leu Glu Arg Ala 
        435                 440                 445             


Lys Asp Gln Leu Glu Lys His Thr Arg Tyr Trp Pro Met Ile Ile Ser 
    450                 455                 460                 


Gln Thr Thr Ile Phe Asn Met Gln Ala Val Val Pro Leu Ala Ser Val 
465                 470                 475                 480 


Ile Val Lys Glu Ser Leu Thr Glu Glu Asp Val Leu Asn Cys Gln Lys 
                485                 490                 495     


Thr Ile Tyr Asn Leu Val Asp Met Glu Arg Lys Asn Asp Pro Leu Pro 
            500                 505                 510         


Ile Ser Thr Val Gly Thr Arg Gly Lys Gly Pro Lys Arg Asp Glu Gln 
        515                 520                 525             


Tyr Arg Ile Met Trp Asn Glu Leu Glu Thr Leu Val Arg Ala His Ile 
    530                 535                 540                 


Asn Asn Ser Glu Lys His Gln Arg Val Leu Glu Cys Leu Met Ala Cys 
545                 550                 555                 560 


Arg Ser Lys Pro Pro Glu Glu Glu Glu Arg Lys Lys Arg Gly Arg Lys 
                565                 570                 575     


Arg Glu Asp Lys Glu Asp Lys Ser Glu Lys Ala Val Lys Asp Tyr Glu 
            580                 585                 590         


Gln Glu Lys Ser Trp Gln Asp Ser Glu Arg Leu Lys Gly Ile Leu Glu 
        595                 600                 605             


Arg Gly Lys Glu Glu Leu Ala Glu Ala Glu Ile Ile Lys Asp Ser Pro 
    610                 615                 620                 


Asp Ser Pro Glu Pro Pro Asn Lys Lys Pro Leu Val Glu Met Asp Glu 
625                 630                 635                 640 


Thr Pro Gln Val Glu Lys Ser Lys Gly Pro Val Ser Leu Leu Ser Leu 
                645                 650                 655     


Trp Ser Asn Arg Ile Asn Thr Ala Asn Ser Arg Lys His Gln Glu Phe 
            660                 665                 670         


Ala Gly Arg Leu Asn Ser Val Asn Asn Arg Ala Glu Leu Tyr Gln His 
        675                 680                 685             


Leu Lys Glu Glu Asn Gly Met Glu Thr Thr Glu Asn Gly Lys Ala Ser 
    690                 695                 700                 


Arg Gln 
705     


<210>  58
<211>  3014
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Ala Pro Pro Pro Pro Pro Val Leu Pro Val Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Ala Ala Ala Leu Pro Ala Met Gly Leu Arg Ala Ala Ala Trp Glu 
            20                  25                  30          


Pro Arg Val Pro Gly Gly Thr Arg Ala Phe Ala Leu Arg Pro Gly Cys 
        35                  40                  45              


Thr Tyr Ala Val Gly Ala Ala Cys Thr Pro Arg Ala Pro Arg Glu Leu 
    50                  55                  60                  


Leu Asp Val Gly Arg Asp Gly Arg Leu Ala Gly Arg Arg Arg Val Ser 
65                  70                  75                  80  


Gly Ala Gly Arg Pro Leu Pro Leu Gln Val Arg Leu Val Ala Arg Ser 
                85                  90                  95      


Ala Pro Thr Ala Leu Ser Arg Arg Leu Arg Ala Arg Thr His Leu Pro 
            100                 105                 110         


Gly Cys Gly Ala Arg Ala Arg Leu Cys Gly Thr Gly Ala Arg Leu Cys 
        115                 120                 125             


Gly Ala Leu Cys Phe Pro Val Pro Gly Gly Cys Ala Ala Ala Gln His 
    130                 135                 140                 


Ser Ala Leu Ala Ala Pro Thr Thr Leu Pro Ala Cys Arg Cys Pro Pro 
145                 150                 155                 160 


Arg Pro Arg Pro Arg Cys Pro Gly Arg Pro Ile Cys Leu Pro Pro Gly 
                165                 170                 175     


Gly Ser Val Arg Leu Arg Leu Leu Cys Ala Leu Arg Arg Ala Ala Gly 
            180                 185                 190         


Ala Val Arg Val Gly Leu Ala Leu Glu Ala Ala Thr Ala Gly Thr Pro 
        195                 200                 205             


Ser Ala Ser Pro Ser Pro Ser Pro Pro Leu Pro Pro Asn Leu Pro Glu 
    210                 215                 220                 


Ala Arg Ala Gly Pro Ala Arg Arg Ala Arg Arg Gly Thr Ser Gly Arg 
225                 230                 235                 240 


Gly Ser Leu Lys Phe Pro Met Pro Asn Tyr Gln Val Ala Leu Phe Glu 
                245                 250                 255     


Asn Glu Pro Ala Gly Thr Leu Ile Leu Gln Leu His Ala His Tyr Thr 
            260                 265                 270         


Ile Glu Gly Glu Glu Glu Arg Val Ser Tyr Tyr Met Glu Gly Leu Phe 
        275                 280                 285             


Asp Glu Arg Ser Arg Gly Tyr Phe Arg Ile Asp Ser Ala Thr Gly Ala 
    290                 295                 300                 


Val Ser Thr Asp Ser Val Leu Asp Arg Glu Thr Lys Glu Thr His Val 
305                 310                 315                 320 


Leu Arg Val Lys Ala Val Asp Tyr Ser Thr Pro Pro Arg Ser Ala Thr 
                325                 330                 335     


Thr Tyr Ile Thr Val Leu Val Lys Asp Thr Asn Asp His Ser Pro Val 
            340                 345                 350         


Phe Glu Gln Ser Glu Tyr Arg Glu Arg Val Arg Glu Asn Leu Glu Val 
        355                 360                 365             


Gly Tyr Glu Val Leu Thr Ile Arg Ala Ser Asp Arg Asp Ser Pro Ile 
    370                 375                 380                 


Asn Ala Asn Leu Arg Tyr Arg Val Leu Gly Gly Ala Trp Asp Val Phe 
385                 390                 395                 400 


Gln Leu Asn Glu Ser Ser Gly Val Val Ser Thr Arg Ala Val Leu Asp 
                405                 410                 415     


Arg Glu Glu Ala Ala Glu Tyr Gln Leu Leu Val Glu Ala Asn Asp Gln 
            420                 425                 430         


Gly Arg Asn Pro Gly Pro Leu Ser Ala Thr Ala Thr Val Tyr Ile Glu 
        435                 440                 445             


Val Glu Asp Glu Asn Asp Asn Tyr Pro Gln Phe Ser Glu Gln Asn Tyr 
    450                 455                 460                 


Val Val Gln Val Pro Glu Asp Val Gly Leu Asn Thr Ala Val Leu Arg 
465                 470                 475                 480 


Val Gln Ala Thr Asp Arg Asp Gln Gly Gln Asn Ala Ala Ile His Tyr 
                485                 490                 495     


Ser Ile Leu Ser Gly Asn Val Ala Gly Gln Phe Tyr Leu His Ser Leu 
            500                 505                 510         


Ser Gly Ile Leu Asp Val Ile Asn Pro Leu Asp Phe Glu Asp Val Gln 
        515                 520                 525             


Lys Tyr Ser Leu Ser Ile Lys Ala Gln Asp Gly Gly Arg Pro Pro Leu 
    530                 535                 540                 


Ile Asn Ser Ser Gly Val Val Ser Val Gln Val Leu Asp Val Asn Asp 
545                 550                 555                 560 


Asn Glu Pro Ile Phe Val Ser Ser Pro Phe Gln Ala Thr Val Leu Glu 
                565                 570                 575     


Asn Val Pro Leu Gly Tyr Pro Val Val His Ile Gln Ala Val Asp Ala 
            580                 585                 590         


Asp Ser Gly Glu Asn Ala Arg Leu His Tyr Arg Leu Val Asp Thr Ala 
        595                 600                 605             


Ser Thr Phe Leu Gly Gly Gly Ser Ala Gly Pro Lys Asn Pro Ala Pro 
    610                 615                 620                 


Thr Pro Asp Phe Pro Phe Gln Ile His Asn Ser Ser Gly Trp Ile Thr 
625                 630                 635                 640 


Val Cys Ala Glu Leu Asp Arg Glu Glu Val Glu His Tyr Ser Phe Gly 
                645                 650                 655     


Val Glu Ala Val Asp His Gly Ser Pro Pro Met Ser Ser Ser Thr Ser 
            660                 665                 670         


Val Ser Ile Thr Val Leu Asp Val Asn Asp Asn Asp Pro Val Phe Thr 
        675                 680                 685             


Gln Pro Thr Tyr Glu Leu Arg Leu Asn Glu Asp Ala Ala Val Gly Ser 
    690                 695                 700                 


Ser Val Leu Thr Leu Gln Ala Arg Asp Arg Asp Ala Asn Ser Val Ile 
705                 710                 715                 720 


Thr Tyr Gln Leu Thr Gly Gly Asn Thr Arg Asn Arg Phe Ala Leu Ser 
                725                 730                 735     


Ser Gln Arg Gly Gly Gly Leu Ile Thr Leu Ala Leu Pro Leu Asp Tyr 
            740                 745                 750         


Lys Gln Glu Gln Gln Tyr Val Leu Ala Val Thr Ala Ser Asp Gly Thr 
        755                 760                 765             


Arg Ser His Thr Ala His Val Leu Ile Asn Val Thr Asp Ala Asn Thr 
    770                 775                 780                 


His Arg Pro Val Phe Gln Ser Ser His Tyr Thr Val Ser Val Ser Glu 
785                 790                 795                 800 


Asp Arg Pro Val Gly Thr Ser Ile Ala Thr Leu Ser Ala Asn Asp Glu 
                805                 810                 815     


Asp Thr Gly Glu Asn Ala Arg Ile Thr Tyr Val Ile Gln Asp Pro Val 
            820                 825                 830         


Pro Gln Phe Arg Ile Asp Pro Asp Ser Gly Thr Met Tyr Thr Met Met 
        835                 840                 845             


Glu Leu Asp Tyr Glu Asn Gln Val Ala Tyr Thr Leu Thr Ile Met Ala 
    850                 855                 860                 


Gln Asp Asn Gly Ile Pro Gln Lys Ser Asp Thr Thr Thr Leu Glu Ile 
865                 870                 875                 880 


Leu Ile Leu Asp Ala Asn Asp Asn Ala Pro Gln Phe Leu Trp Asp Phe 
                885                 890                 895     


Tyr Gln Gly Ser Ile Phe Glu Asp Ala Pro Pro Ser Thr Ser Ile Leu 
            900                 905                 910         


Gln Val Ser Ala Thr Asp Arg Asp Ser Gly Pro Asn Gly Arg Leu Leu 
        915                 920                 925             


Tyr Thr Phe Gln Gly Gly Asp Asp Gly Asp Gly Asp Phe Tyr Ile Glu 
    930                 935                 940                 


Pro Thr Ser Gly Val Ile Arg Thr Gln Arg Arg Leu Asp Arg Glu Asn 
945                 950                 955                 960 


Val Ala Val Tyr Asn Leu Trp Ala Leu Ala Val Asp Arg Gly Ser Pro 
                965                 970                 975     


Thr Pro Leu Ser Ala Ser Val Glu Ile Gln Val Thr Ile Leu Asp Ile 
            980                 985                 990         


Asn Asp Asn Ala Pro Met Phe Glu  Lys Asp Glu Leu Glu  Leu Phe Val 
        995                 1000                 1005             


Glu Glu  Asn Asn Pro Val Gly  Ser Val Val Ala Lys  Ile Arg Ala 
    1010                 1015                 1020             


Asn Asp  Pro Asp Glu Gly Pro  Asn Ala Gln Ile Met  Tyr Gln Ile 
    1025                 1030                 1035             


Val Glu  Gly Asp Met Arg His  Phe Phe Gln Leu Asp  Leu Leu Asn 
    1040                 1045                 1050             


Gly Asp  Leu Arg Ala Met Val  Glu Leu Asp Phe Glu  Val Arg Arg 
    1055                 1060                 1065             


Glu Tyr  Val Leu Val Val Gln  Ala Thr Ser Ala Pro  Leu Val Ser 
    1070                 1075                 1080             


Arg Ala  Thr Val His Ile Leu  Leu Val Asp Gln Asn  Asp Asn Pro 
    1085                 1090                 1095             


Pro Val  Leu Pro Asp Phe Gln  Ile Leu Phe Asn Asn  Tyr Val Thr 
    1100                 1105                 1110             


Asn Lys  Ser Asn Ser Phe Pro  Thr Gly Val Ile Gly  Cys Ile Pro 
    1115                 1120                 1125             


Ala His  Asp Pro Asp Val Ser  Asp Ser Leu Asn Tyr  Thr Phe Val 
    1130                 1135                 1140             


Gln Gly  Asn Glu Leu Arg Leu  Leu Leu Leu Asp Pro  Ala Thr Gly 
    1145                 1150                 1155             


Glu Leu  Gln Leu Ser Arg Asp  Leu Asp Asn Asn Arg  Pro Leu Glu 
    1160                 1165                 1170             


Ala Leu  Met Glu Val Ser Val  Ser Asp Gly Ile His  Ser Val Thr 
    1175                 1180                 1185             


Ala Phe  Cys Thr Leu Arg Val  Thr Ile Ile Thr Asp  Asp Met Leu 
    1190                 1195                 1200             


Thr Asn  Ser Ile Thr Val Arg  Leu Glu Asn Met Ser  Gln Glu Lys 
    1205                 1210                 1215             


Phe Leu  Ser Pro Leu Leu Ala  Leu Phe Val Glu Gly  Val Ala Ala 
    1220                 1225                 1230             


Val Leu  Ser Thr Thr Lys Asp  Asp Val Phe Val Phe  Asn Val Gln 
    1235                 1240                 1245             


Asn Asp  Thr Asp Val Ser Ser  Asn Ile Leu Asn Val  Thr Phe Ser 
    1250                 1255                 1260             


Ala Leu  Leu Pro Gly Gly Val  Arg Gly Gln Phe Phe  Pro Ser Glu 
    1265                 1270                 1275             


Asp Leu  Gln Glu Gln Ile Tyr  Leu Asn Arg Thr Leu  Leu Thr Thr 
    1280                 1285                 1290             


Ile Ser  Thr Gln Arg Val Leu  Pro Phe Asp Asp Asn  Ile Cys Leu 
    1295                 1300                 1305             


Arg Glu  Pro Cys Glu Asn Tyr  Met Lys Cys Val Ser  Val Leu Arg 
    1310                 1315                 1320             


Phe Asp  Ser Ser Ala Pro Phe  Leu Ser Ser Thr Thr  Val Leu Phe 
    1325                 1330                 1335             


Arg Pro  Ile His Pro Ile Asn  Gly Leu Arg Cys Arg  Cys Pro Pro 
    1340                 1345                 1350             


Gly Phe  Thr Gly Asp Tyr Cys  Glu Thr Glu Ile Asp  Leu Cys Tyr 
    1355                 1360                 1365             


Ser Asp  Pro Cys Gly Ala Asn  Gly Arg Cys Arg Ser  Arg Glu Gly 
    1370                 1375                 1380             


Gly Tyr  Thr Cys Glu Cys Phe  Glu Asp Phe Thr Gly  Glu His Cys 
    1385                 1390                 1395             


Glu Val  Asp Ala Arg Ser Gly  Arg Cys Ala Asn Gly  Val Cys Lys 
    1400                 1405                 1410             


Asn Gly  Gly Thr Cys Val Asn  Leu Leu Ile Gly Gly  Phe His Cys 
    1415                 1420                 1425             


Val Cys  Pro Pro Gly Glu Tyr  Glu Arg Pro Tyr Cys  Glu Val Thr 
    1430                 1435                 1440             


Thr Arg  Ser Phe Pro Pro Gln  Ser Phe Val Thr Phe  Arg Gly Leu 
    1445                 1450                 1455             


Arg Gln  Arg Phe His Phe Thr  Ile Ser Leu Thr Phe  Ala Thr Gln 
    1460                 1465                 1470             


Glu Arg  Asn Gly Leu Leu Leu  Tyr Asn Gly Arg Phe  Asn Glu Lys 
    1475                 1480                 1485             


His Asp  Phe Ile Ala Leu Glu  Ile Val Asp Glu Gln  Val Gln Leu 
    1490                 1495                 1500             


Thr Phe  Ser Ala Gly Glu Thr  Thr Thr Thr Val Ala  Pro Lys Val 
    1505                 1510                 1515             


Pro Ser  Gly Val Ser Asp Gly  Arg Trp His Ser Val  Gln Val Gln 
    1520                 1525                 1530             


Tyr Tyr  Asn Lys Pro Asn Ile  Gly His Leu Gly Leu  Pro His Gly 
    1535                 1540                 1545             


Pro Ser  Gly Glu Lys Met Ala  Val Val Thr Val Asp  Asp Cys Asp 
    1550                 1555                 1560             


Thr Thr  Met Ala Val Arg Phe  Gly Lys Asp Ile Gly  Asn Tyr Ser 
    1565                 1570                 1575             


Cys Ala  Ala Gln Gly Thr Gln  Thr Gly Ser Lys Lys  Ser Leu Asp 
    1580                 1585                 1590             


Leu Thr  Gly Pro Leu Leu Leu  Gly Gly Val Pro Asn  Leu Pro Glu 
    1595                 1600                 1605             


Asp Phe  Pro Val His Asn Arg  Gln Phe Val Gly Cys  Met Arg Asn 
    1610                 1615                 1620             


Leu Ser  Val Asp Gly Lys Asn  Val Asp Met Ala Gly  Phe Ile Ala 
    1625                 1630                 1635             


Asn Asn  Gly Thr Arg Glu Gly  Cys Ala Ala Arg Arg  Asn Phe Cys 
    1640                 1645                 1650             


Asp Gly  Arg Arg Cys Gln Asn  Gly Gly Thr Cys Val  Asn Arg Trp 
    1655                 1660                 1665             


Asn Met  Tyr Leu Cys Glu Cys  Pro Leu Arg Phe Gly  Gly Lys Asn 
    1670                 1675                 1680             


Cys Glu  Gln Ala Met Pro His  Pro Gln Leu Phe Ser  Gly Glu Ser 
    1685                 1690                 1695             


Val Val  Ser Trp Ser Asp Leu  Asn Ile Ile Ile Ser  Val Pro Trp 
    1700                 1705                 1710             


Tyr Leu  Gly Leu Met Phe Arg  Thr Arg Lys Glu Asp  Ser Val Leu 
    1715                 1720                 1725             


Met Glu  Ala Thr Ser Gly Gly  Pro Thr Ser Phe Arg  Leu Gln Ile 
    1730                 1735                 1740             


Leu Asn  Asn Tyr Leu Gln Phe  Glu Val Ser His Gly  Pro Ser Asp 
    1745                 1750                 1755             


Val Glu  Ser Val Met Leu Ser  Gly Leu Arg Val Thr  Asp Gly Glu 
    1760                 1765                 1770             


Trp His  His Leu Leu Ile Glu  Leu Lys Asn Val Lys  Glu Asp Ser 
    1775                 1780                 1785             


Glu Met  Lys His Leu Val Thr  Met Thr Leu Asp Tyr  Gly Met Asp 
    1790                 1795                 1800             


Gln Asn  Lys Ala Asp Ile Gly  Gly Met Leu Pro Gly  Leu Thr Val 
    1805                 1810                 1815             


Arg Ser  Val Val Val Gly Gly  Ala Ser Glu Asp Lys  Val Ser Val 
    1820                 1825                 1830             


Arg Arg  Gly Phe Arg Gly Cys  Met Gln Gly Val Arg  Met Gly Gly 
    1835                 1840                 1845             


Thr Pro  Thr Asn Val Ala Thr  Leu Asn Met Asn Asn  Ala Leu Lys 
    1850                 1855                 1860             


Val Arg  Val Lys Asp Gly Cys  Asp Val Asp Asp Pro  Cys Thr Ser 
    1865                 1870                 1875             


Ser Pro  Cys Pro Pro Asn Ser  Arg Cys His Asp Ala  Trp Glu Asp 
    1880                 1885                 1890             


Tyr Ser  Cys Val Cys Asp Lys  Gly Tyr Leu Gly Ile  Asn Cys Val 
    1895                 1900                 1905             


Asp Ala  Cys His Leu Asn Pro  Cys Glu Asn Met Gly  Ala Cys Val 
    1910                 1915                 1920             


Arg Ser  Pro Gly Ser Pro Gln  Gly Tyr Val Cys Glu  Cys Gly Pro 
    1925                 1930                 1935             


Ser His  Tyr Gly Pro Tyr Cys  Glu Asn Lys Leu Asp  Leu Pro Cys 
    1940                 1945                 1950             


Pro Arg  Gly Trp Trp Gly Asn  Pro Val Cys Gly Pro  Cys His Cys 
    1955                 1960                 1965             


Ala Val  Ser Lys Gly Phe Asp  Pro Asp Cys Asn Lys  Thr Asn Gly 
    1970                 1975                 1980             


Gln Cys  Gln Cys Lys Glu Asn  Tyr Tyr Lys Leu Leu  Ala Gln Asp 
    1985                 1990                 1995             


Thr Cys  Leu Pro Cys Asp Cys  Phe Pro His Gly Ser  His Ser Arg 
    2000                 2005                 2010             


Thr Cys  Asp Met Ala Thr Gly  Gln Cys Ala Cys Lys  Pro Gly Val 
    2015                 2020                 2025             


Ile Gly  Arg Gln Cys Asn Arg  Cys Asp Asn Pro Phe  Ala Glu Val 
    2030                 2035                 2040             


Thr Thr  Leu Gly Cys Glu Val  Ile Tyr Asn Gly Cys  Pro Lys Ala 
    2045                 2050                 2055             


Phe Glu  Ala Gly Ile Trp Trp  Pro Gln Thr Lys Phe  Gly Gln Pro 
    2060                 2065                 2070             


Ala Ala  Val Pro Cys Pro Lys  Gly Ser Val Gly Asn  Ala Val Arg 
    2075                 2080                 2085             


His Cys  Ser Gly Glu Lys Gly  Trp Leu Pro Pro Glu  Leu Phe Asn 
    2090                 2095                 2100             


Cys Thr  Thr Ile Ser Phe Val  Asp Leu Arg Ala Met  Asn Glu Lys 
    2105                 2110                 2115             


Leu Ser  Arg Asn Glu Thr Gln  Val Asp Gly Ala Arg  Ala Leu Gln 
    2120                 2125                 2130             


Leu Val  Arg Ala Leu Arg Ser  Ala Thr Gln His Thr  Gly Thr Leu 
    2135                 2140                 2145             


Phe Gly  Asn Asp Val Arg Thr  Ala Tyr Gln Leu Leu  Gly His Val 
    2150                 2155                 2160             


Leu Gln  His Glu Ser Trp Gln  Gln Gly Phe Asp Leu  Ala Ala Thr 
    2165                 2170                 2175             


Gln Asp  Ala Asp Phe His Glu  Asp Val Ile His Ser  Gly Ser Ala 
    2180                 2185                 2190             


Leu Leu  Ala Pro Ala Thr Arg  Ala Ala Trp Glu Gln  Ile Gln Arg 
    2195                 2200                 2205             


Ser Glu  Gly Gly Thr Ala Gln  Leu Leu Arg Arg Leu  Glu Gly Tyr 
    2210                 2215                 2220             


Phe Ser  Asn Val Ala Arg Asn  Val Arg Arg Thr Tyr  Leu Arg Pro 
    2225                 2230                 2235             


Phe Val  Ile Val Thr Ala Asn  Met Ile Leu Ala Val  Asp Ile Phe 
    2240                 2245                 2250             


Asp Lys  Phe Asn Phe Thr Gly  Ala Arg Val Pro Arg  Phe Asp Thr 
    2255                 2260                 2265             


Ile His  Glu Glu Phe Pro Arg  Glu Leu Glu Ser Ser  Val Ser Phe 
    2270                 2275                 2280             


Pro Ala  Asp Phe Phe Arg Pro  Pro Glu Glu Lys Glu  Gly Pro Leu 
    2285                 2290                 2295             


Leu Arg  Pro Ala Gly Arg Arg  Thr Thr Pro Gln Thr  Thr Arg Pro 
    2300                 2305                 2310             


Gly Pro  Gly Thr Glu Arg Glu  Ala Pro Ile Ser Arg  Arg Arg Arg 
    2315                 2320                 2325             


His Pro  Asp Asp Ala Gly Gln  Phe Ala Val Ala Leu  Val Ile Ile 
    2330                 2335                 2340             


Tyr Arg  Thr Leu Gly Gln Leu  Leu Pro Glu Arg Tyr  Asp Pro Asp 
    2345                 2350                 2355             


Arg Arg  Ser Leu Arg Leu Pro  His Arg Pro Ile Ile  Asn Thr Pro 
    2360                 2365                 2370             


Met Val  Ser Thr Leu Val Tyr  Ser Glu Gly Ala Pro  Leu Pro Arg 
    2375                 2380                 2385             


Pro Leu  Glu Arg Pro Val Leu  Val Glu Phe Ala Leu  Leu Glu Val 
    2390                 2395                 2400             


Glu Glu  Arg Thr Lys Pro Val  Cys Val Phe Trp Asn  His Ser Leu 
    2405                 2410                 2415             


Ala Val  Gly Gly Thr Gly Gly  Trp Ser Ala Arg Gly  Cys Glu Leu 
    2420                 2425                 2430             


Leu Ser  Arg Asn Arg Thr His  Val Ala Cys Gln Cys  Ser His Thr 
    2435                 2440                 2445             


Ala Ser  Phe Ala Val Leu Met  Asp Ile Ser Arg Arg  Glu Asn Gly 
    2450                 2455                 2460             


Glu Val  Leu Pro Leu Lys Ile  Val Thr Tyr Ala Ala  Val Ser Leu 
    2465                 2470                 2475             


Ser Leu  Ala Ala Leu Leu Val  Ala Phe Val Leu Leu  Ser Leu Val 
    2480                 2485                 2490             


Arg Met  Leu Arg Ser Asn Leu  His Ser Ile His Lys  His Leu Ala 
    2495                 2500                 2505             


Val Ala  Leu Phe Leu Ser Gln  Leu Val Phe Val Ile  Gly Ile Asn 
    2510                 2515                 2520             


Gln Thr  Glu Asn Pro Phe Leu  Cys Thr Val Val Ala  Ile Leu Leu 
    2525                 2530                 2535             


His Tyr  Ile Tyr Met Ser Thr  Phe Ala Trp Thr Leu  Val Glu Ser 
    2540                 2545                 2550             


Leu His  Val Tyr Arg Met Leu  Thr Glu Val Arg Asn  Ile Asp Thr 
    2555                 2560                 2565             


Gly Pro  Met Arg Phe Tyr Tyr  Val Val Gly Trp Gly  Ile Pro Ala 
    2570                 2575                 2580             


Ile Val  Thr Gly Leu Ala Val  Gly Leu Asp Pro Gln  Gly Tyr Gly 
    2585                 2590                 2595             


Asn Pro  Asp Phe Cys Trp Leu  Ser Leu Gln Asp Thr  Leu Ile Trp 
    2600                 2605                 2610             


Ser Phe  Ala Gly Pro Ile Gly  Ala Val Ile Ile Ile  Asn Thr Val 
    2615                 2620                 2625             


Thr Ser  Val Leu Ser Ala Lys  Val Ser Cys Gln Arg  Lys His His 
    2630                 2635                 2640             


Tyr Tyr  Gly Lys Lys Gly Ile  Val Ser Leu Leu Arg  Thr Ala Phe 
    2645                 2650                 2655             


Leu Leu  Leu Leu Leu Ile Ser  Ala Thr Trp Leu Leu  Gly Leu Leu 
    2660                 2665                 2670             


Ala Val  Asn Arg Asp Ala Leu  Ser Phe His Tyr Leu  Phe Ala Ile 
    2675                 2680                 2685             


Phe Ser  Gly Leu Gln Gly Pro  Phe Val Leu Leu Phe  His Cys Val 
    2690                 2695                 2700             


Leu Asn  Gln Glu Val Arg Lys  His Leu Lys Gly Val  Leu Gly Gly 
    2705                 2710                 2715             


Arg Lys  Leu His Leu Glu Asp  Ser Ala Thr Thr Arg  Ala Thr Leu 
    2720                 2725                 2730             


Leu Thr  Arg Ser Leu Asn Cys  Asn Thr Thr Phe Gly  Asp Gly Pro 
    2735                 2740                 2745             


Asp Met  Leu Arg Thr Asp Leu  Gly Glu Ser Thr Ala  Ser Leu Asp 
    2750                 2755                 2760             


Ser Ile  Val Arg Asp Glu Gly  Ile Gln Lys Leu Gly  Val Ser Ser 
    2765                 2770                 2775             


Gly Leu  Val Arg Gly Ser His  Gly Glu Pro Asp Ala  Ser Leu Met 
    2780                 2785                 2790             


Pro Arg  Ser Cys Lys Asp Pro  Pro Gly His Asp Ser  Asp Ser Asp 
    2795                 2800                 2805             


Ser Glu  Leu Ser Leu Asp Glu  Gln Ser Ser Ser Tyr  Ala Ser Ser 
    2810                 2815                 2820             


His Ser  Ser Asp Ser Glu Asp  Asp Gly Val Gly Ala  Glu Glu Lys 
    2825                 2830                 2835             


Trp Asp  Pro Ala Arg Gly Ala  Val His Ser Thr Pro  Lys Gly Asp 
    2840                 2845                 2850             


Ala Val  Ala Asn His Val Pro  Ala Gly Trp Pro Asp  Gln Ser Leu 
    2855                 2860                 2865             


Ala Glu  Ser Asp Ser Glu Asp  Pro Ser Gly Lys Pro  Arg Leu Lys 
    2870                 2875                 2880             


Val Glu  Thr Lys Val Ser Val  Glu Leu His Arg Glu  Glu Gln Gly 
    2885                 2890                 2895             


Ser His  Arg Gly Glu Tyr Pro  Pro Asp Gln Glu Ser  Gly Gly Ala 
    2900                 2905                 2910             


Ala Arg  Leu Ala Ser Ser Gln  Pro Pro Glu Gln Arg  Lys Gly Ile 
    2915                 2920                 2925             


Leu Lys  Asn Lys Val Thr Tyr  Pro Pro Pro Leu Thr  Leu Thr Glu 
    2930                 2935                 2940             


Gln Thr  Leu Lys Gly Arg Leu  Arg Glu Lys Leu Ala  Asp Cys Glu 
    2945                 2950                 2955             


Gln Ser  Pro Thr Ser Ser Arg  Thr Ser Ser Leu Gly  Ser Gly Gly 
    2960                 2965                 2970             


Pro Asp  Cys Ala Ile Thr Val  Lys Ser Pro Gly Arg  Glu Pro Gly 
    2975                 2980                 2985             


Arg Asp  His Leu Asn Gly Val  Ala Met Asn Val Arg  Thr Gly Ser 
    2990                 2995                 3000             


Ala Gln  Ala Asp Gly Ser Asp  Ser Glu Lys Pro 
    3005                 3010                 


<210>  59
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Glu Arg Arg Arg Leu Trp Gly Ser Ile Gln Ser Arg Tyr Ile Ser 
1               5                   10                  15      


Met Ser Val Trp Thr Ser Pro Arg Arg Leu Val Glu Leu Ala Gly Gln 
            20                  25                  30          


Ser Leu Leu Lys Asp Glu Ala Leu Ala Ile Ala Ala Leu Glu Leu Leu 
        35                  40                  45              


Pro Arg Glu Leu Phe Pro Pro Leu Phe Met Ala Ala Phe Asp Gly Arg 
    50                  55                  60                  


His Ser Gln Thr Leu Lys Ala Met Val Gln Ala Trp Pro Phe Thr Cys 
65                  70                  75                  80  


Leu Pro Leu Gly Val Leu Met Lys Gly Gln His Leu His Leu Glu Thr 
                85                  90                  95      


Phe Lys Ala Val Leu Asp Gly Leu Asp Val Leu Leu Ala Gln Glu Val 
            100                 105                 110         


Arg Pro Arg Arg Trp Lys Leu Gln Val Leu Asp Leu Arg Lys Asn Ser 
        115                 120                 125             


His Gln Asp Phe Trp Thr Val Trp Ser Gly Asn Arg Ala Ser Leu Tyr 
    130                 135                 140                 


Ser Phe Pro Glu Pro Glu Ala Ala Gln Pro Met Thr Lys Lys Arg Lys 
145                 150                 155                 160 


Val Asp Gly Leu Ser Thr Glu Ala Glu Gln Pro Phe Ile Pro Val Glu 
                165                 170                 175     


Val Leu Val Asp Leu Phe Leu Lys Glu Gly Ala Cys Asp Glu Leu Phe 
            180                 185                 190         


Ser Tyr Leu Ile Glu Lys Val Lys Arg Lys Lys Asn Val Leu Arg Leu 
        195                 200                 205             


Cys Cys Lys Lys Leu Lys Ile Phe Ala Met Pro Met Gln Asp Ile Lys 
    210                 215                 220                 


Met Ile Leu Lys Met Val Gln Leu Asp Ser Ile Glu Asp Leu Glu Val 
225                 230                 235                 240 


Thr Cys Thr Trp Lys Leu Pro Thr Leu Ala Lys Phe Ser Pro Tyr Leu 
                245                 250                 255     


Gly Gln Met Ile Asn Leu Arg Arg Leu Leu Leu Ser His Ile His Ala 
            260                 265                 270         


Ser Ser Tyr Ile Ser Pro Glu Lys Glu Glu Gln Tyr Ile Ala Gln Phe 
        275                 280                 285             


Thr Ser Gln Phe Leu Ser Leu Gln Cys Leu Gln Ala Leu Tyr Val Asp 
    290                 295                 300                 


Ser Leu Phe Phe Leu Arg Gly Arg Leu Asp Gln Leu Leu Arg His Val 
305                 310                 315                 320 


Met Asn Pro Leu Glu Thr Leu Ser Ile Thr Asn Cys Arg Leu Ser Glu 
                325                 330                 335     


Gly Asp Val Met His Leu Ser Gln Ser Pro Ser Val Ser Gln Leu Ser 
            340                 345                 350         


Val Leu Ser Leu Ser Gly Val Met Leu Thr Asp Val Ser Pro Glu Pro 
        355                 360                 365             


Leu Gln Ala Leu Leu Glu Arg Ala Ser Ala Thr Leu Gln Asp Leu Val 
    370                 375                 380                 


Phe Asp Glu Cys Gly Ile Thr Asp Asp Gln Leu Leu Ala Leu Leu Pro 
385                 390                 395                 400 


Ser Leu Ser His Cys Ser Gln Leu Thr Thr Leu Ser Phe Tyr Gly Asn 
                405                 410                 415     


Ser Ile Ser Ile Ser Ala Leu Gln Ser Leu Leu Gln His Leu Ile Gly 
            420                 425                 430         


Leu Ser Asn Leu Thr His Val Leu Tyr Pro Val Pro Leu Glu Ser Tyr 
        435                 440                 445             


Glu Asp Ile His Gly Thr Leu His Leu Glu Arg Leu Ala Tyr Leu His 
    450                 455                 460                 


Ala Arg Leu Arg Glu Leu Leu Cys Glu Leu Gly Arg Pro Ser Met Val 
465                 470                 475                 480 


Trp Leu Ser Ala Asn Pro Cys Pro His Cys Gly Asp Arg Thr Phe Tyr 
                485                 490                 495     


Asp Pro Glu Pro Ile Leu Cys Pro Cys Phe Met Pro Asn 
            500                 505                 


<210>  60
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  60

Ile Glu Ala Asp Leu Gly Tyr Pro Gly Gly Lys Ala Arg Ile Ile His 
1               5                   10                  15      


Lys Glu Ser Asp Ile Ile Thr Ala Phe Ala Val Asn Lys Ala Asn Arg 
            20                  25                  30          


Asn Cys Ile Ala Ile Ala Ser Ser His Asp Val Gln Glu Leu Asp Val 
        35                  40                  45              


Ser Gly Ile Leu Ala Thr Gln Ile Tyr Thr Trp Val Asp Asp Asp Ala 
    50                  55                  60                  


Glu Met Glu Thr Lys Gly Ser Glu Asp Phe Leu Val Ile His Ala Arg 
65                  70                  75                  80  


Asp Asp Leu Thr Ala Val Gln Gly Thr Thr Pro Tyr Thr His Ser Asn 
                85                  90                  95      


Pro Gly Thr Pro Ile Asn Met Pro Trp Leu Gly Ser Thr Gln Thr Gly 
            100                 105                 110         


Arg Gly Ala Ser Val Met Ile Lys Lys Ala Ile Asn Asn Val Arg Arg 
        115                 120                 125             


Met Thr Ser His Pro Thr Leu Pro Tyr Tyr Leu Thr Gly Ala Gln Asp 
    130                 135                 140                 


Gly Ser Val Arg Met Phe Glu Trp Gly His Ser Gln Gln Ile Thr Cys 
145                 150                 155                 160 


Phe Arg Ser Gly Gly Asn Ser Arg Val Thr Arg Met Arg Phe Asn Tyr 
                165                 170                 175     


Gln Gly Asn Lys Phe Gly Ile Val Asp Ala Asp Gly Tyr Leu Ser Leu 
            180                 185                 190         


Tyr Gln Thr Asn Trp Lys Cys Cys Pro Val Thr Gly Ser Met Pro Lys 
        195                 200                 205             


Pro Tyr Leu Thr Trp Gln Cys His Asn Lys Thr Ala Asn Asp Phe Val 
    210                 215                 220                 


Phe Val Ser Ser Ser Ser Leu Ile Ala Thr Ala Gly Leu Ser Thr Asp 
225                 230                 235                 240 


Asn Arg Asn Ile Cys Leu Trp Asp Thr Leu Val Ala Pro Ala Asn Ser 
                245                 250                 255     


Leu Val His Ala Phe Thr Cys His Asp Ser Gly Ala Thr Val Leu Ala 
            260                 265                 270         


Tyr Ala Pro Lys His Gln Leu Leu Ile Ser Gly Gly Arg Lys Gly Phe 
        275                 280                 285             


Thr Cys Ala Phe Asp Leu Arg Gln Arg Gln Gln Arg Gln Leu Phe Gln 
    290                 295                 300                 


Ser His Asp Ser Pro Val Lys Ala Ile Ala Ile Asp Pro Thr Glu Glu 
305                 310                 315                 320 


Tyr Phe Val Thr Gly Ser Ala Glu Gly Asn Ile Lys Ile Trp Ser Leu 
                325                 330                 335     


Ser Thr Phe Ser Leu Leu His Thr Phe Ile Asn Glu His Ala Arg Gln 
            340                 345                 350         


Ser Ile Phe Arg Asn Ile Gly Thr Gly Val Met Gln Ile Glu Thr Gly 
        355                 360                 365             


Pro Ala Asn His Ile Phe Ser Cys Gly Ala Asp Gly Thr Met Lys Met 
    370                 375                 380                 


Arg Ile Leu Pro Asp Gln Phe Ser Pro Leu Asn Glu Val Leu Arg Asn 
385                 390                 395                 400 


Asp Val Lys Phe Met Leu 
                405     


<210>  61
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Gly Ala Pro Thr Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp 
1               5                   10                  15      


His Arg Ile Ser Thr Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala 
            20                  25                  30          


Cys Thr Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Thr 
        35                  40                  45              


Glu Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu 
    50                  55                  60                  


Glu Gly Trp Glu Pro Asp Asp Asp Pro Ile Glu Glu His Lys Lys His 
65                  70                  75                  80  


Ser Ser Gly Cys Ala Phe Leu Ser Val Lys Lys Gln Phe Glu Glu Leu 
                85                  90                  95      


Thr Leu Gly Glu Phe Leu Lys Leu Asp Arg Glu Arg Ala Lys Asn Lys 
            100                 105                 110         


Ile Ala Lys Glu Thr Asn Asn Lys Lys Lys Glu Phe Glu Glu Thr Ala 
        115                 120                 125             


Lys Lys Val Arg Arg Ala Ile Glu Gln Leu Ala Ala Met Asp 
    130                 135                 140         


<210>  62
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Arg Val Asn Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser 
1               5                   10                  15      


Glu Leu Asp Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe 
            20                  25                  30          


Glu Thr Ser Ala Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Cys 
        35                  40                  45              


Lys Met Trp Ala Ile Gly Ile Thr Val Leu Val Ile Phe Ile Ile Ile 
    50                  55                  60                  


Ile Ile Val Trp Val Val Ser Ser 
65                  70          


<210>  63
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly 
        275                 280                 285             


Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu 
    290                 295                 300                 


Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg 
305                 310                 315                 320 


Arg Lys Arg Lys Arg Met Thr Asp Pro Thr Arg Arg Phe Phe Lys Val 
                325                 330                 335     


Thr Pro Pro Pro Gly Ser Gly Pro Gln Asn Gln Tyr Gly Asn Val Leu 
            340                 345                 350         


Ser Leu Pro Thr Pro Thr Ser Gly Leu Gly Arg Ala Gln Arg Trp Ala 
        355                 360                 365             


Ala Gly Leu Gly Gly Thr Ala Pro Ser Tyr Gly Asn Pro Ser Ser Asp 
    370                 375                 380                 


Val Gln Ala Asp Gly Ala Leu Gly Ser Arg Ser Pro Pro Gly Val Gly 
385                 390                 395                 400 


Pro Glu Glu Glu Glu Gly Glu Gly Tyr Glu Glu Pro Asp Ser Glu Glu 
                405                 410                 415     


Asp Ser Glu Phe Tyr Glu Asn Asp Ser Asn Leu Gly Gln Asp Gln Leu 
            420                 425                 430         


Ser Gln Asp Gly Ser Gly Tyr Glu Asn Pro Glu Asp Glu Pro Leu Gly 
        435                 440                 445             


Pro Glu Asp Glu Asp Ser Phe Ser Asn Ala Glu Ser Tyr Glu Asn Glu 
    450                 455                 460                 


Asp Glu Glu Leu Thr Gln Pro Val Ala Arg Thr Met Asp Phe Leu Ser 
465                 470                 475                 480 


Pro His Gly Ser Ala Trp Asp Pro Ser Arg Glu Ala Thr Ser Leu Gly 
                485                 490                 495     


Ser Gln Ser Tyr Glu Asp Met Arg Gly Ile Leu Tyr Ala Ala Pro Gln 
            500                 505                 510         


Leu Arg Ser Ile Arg Gly Gln Pro Gly Pro Asn His Glu Glu Asp Ala 
        515                 520                 525             


Asp Ser Tyr Glu Asn Met Asp Asn Pro Asp Gly Pro Asp Pro Ala Trp 
    530                 535                 540                 


Gly Gly Gly Gly Arg Met Gly Thr Trp Ser Thr Arg 
545                 550                 555     


<210>  64
<211>  825
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Gly Trp Leu Cys Ser Gly Leu Leu Phe Pro Val Ser Cys Leu Val 
1               5                   10                  15      


Leu Leu Gln Val Ala Ser Ser Gly Asn Met Lys Val Leu Gln Glu Pro 
            20                  25                  30          


Thr Cys Val Ser Asp Tyr Met Ser Ile Ser Thr Cys Glu Trp Lys Met 
        35                  40                  45              


Asn Gly Pro Thr Asn Cys Ser Thr Glu Leu Arg Leu Leu Tyr Gln Leu 
    50                  55                  60                  


Val Phe Leu Leu Ser Glu Ala His Thr Cys Ile Pro Glu Asn Asn Gly 
65                  70                  75                  80  


Gly Ala Gly Cys Val Cys His Leu Leu Met Asp Asp Val Val Ser Ala 
                85                  90                  95      


Asp Asn Tyr Thr Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp Lys 
            100                 105                 110         


Gly Ser Phe Lys Pro Ser Glu His Val Lys Pro Arg Ala Pro Gly Asn 
        115                 120                 125             


Leu Thr Val His Thr Asn Val Ser Asp Thr Leu Leu Leu Thr Trp Ser 
    130                 135                 140                 


Asn Pro Tyr Pro Pro Asp Asn Tyr Leu Tyr Asn His Leu Thr Tyr Ala 
145                 150                 155                 160 


Val Asn Ile Trp Ser Glu Asn Asp Pro Ala Asp Phe Arg Ile Tyr Asn 
                165                 170                 175     


Val Thr Tyr Leu Glu Pro Ser Leu Arg Ile Ala Ala Ser Thr Leu Lys 
            180                 185                 190         


Ser Gly Ile Ser Tyr Arg Ala Arg Val Arg Ala Trp Ala Gln Cys Tyr 
        195                 200                 205             


Asn Thr Thr Trp Ser Glu Trp Ser Pro Ser Thr Lys Trp His Asn Ser 
    210                 215                 220                 


Tyr Arg Glu Pro Phe Glu Gln His Leu Leu Leu Gly Val Ser Val Ser 
225                 230                 235                 240 


Cys Ile Val Ile Leu Ala Val Cys Leu Leu Cys Tyr Val Ser Ile Thr 
                245                 250                 255     


Lys Ile Lys Lys Glu Trp Trp Asp Gln Ile Pro Asn Pro Ala Arg Ser 
            260                 265                 270         


Arg Leu Val Ala Ile Ile Ile Gln Asp Ala Gln Gly Ser Gln Trp Glu 
        275                 280                 285             


Lys Arg Ser Arg Gly Gln Glu Pro Ala Lys Cys Pro His Trp Lys Asn 
    290                 295                 300                 


Cys Leu Thr Lys Leu Leu Pro Cys Phe Leu Glu His Asn Met Lys Arg 
305                 310                 315                 320 


Asp Glu Asp Pro His Lys Ala Ala Lys Glu Met Pro Phe Gln Gly Ser 
                325                 330                 335     


Gly Lys Ser Ala Trp Cys Pro Val Glu Ile Ser Lys Thr Val Leu Trp 
            340                 345                 350         


Pro Glu Ser Ile Ser Val Val Arg Cys Val Glu Leu Phe Glu Ala Pro 
        355                 360                 365             


Val Glu Cys Glu Glu Glu Glu Glu Val Glu Glu Glu Lys Gly Ser Phe 
    370                 375                 380                 


Cys Ala Ser Pro Glu Ser Ser Arg Asp Asp Phe Gln Glu Gly Arg Glu 
385                 390                 395                 400 


Gly Ile Val Ala Arg Leu Thr Glu Ser Leu Phe Leu Asp Leu Leu Gly 
                405                 410                 415     


Glu Glu Asn Gly Gly Phe Cys Gln Gln Asp Met Gly Glu Ser Cys Leu 
            420                 425                 430         


Leu Pro Pro Ser Gly Ser Thr Ser Ala His Met Pro Trp Asp Glu Phe 
        435                 440                 445             


Pro Ser Ala Gly Pro Lys Glu Ala Pro Pro Trp Gly Lys Glu Gln Pro 
    450                 455                 460                 


Leu His Leu Glu Pro Ser Pro Pro Ala Ser Pro Thr Gln Ser Pro Asp 
465                 470                 475                 480 


Asn Leu Thr Cys Thr Glu Thr Pro Leu Val Ile Ala Gly Asn Pro Ala 
                485                 490                 495     


Tyr Arg Ser Phe Ser Asn Ser Leu Ser Gln Ser Pro Cys Pro Arg Glu 
            500                 505                 510         


Leu Gly Pro Asp Pro Leu Leu Ala Arg His Leu Glu Glu Val Glu Pro 
        515                 520                 525             


Glu Met Pro Cys Val Pro Gln Leu Ser Glu Pro Thr Thr Val Pro Gln 
    530                 535                 540                 


Pro Glu Pro Glu Thr Trp Glu Gln Ile Leu Arg Arg Asn Val Leu Gln 
545                 550                 555                 560 


His Gly Ala Ala Ala Ala Pro Val Ser Ala Pro Thr Ser Gly Tyr Gln 
                565                 570                 575     


Glu Phe Val His Ala Val Glu Gln Gly Gly Thr Gln Ala Ser Ala Val 
            580                 585                 590         


Val Gly Leu Gly Pro Pro Gly Glu Ala Gly Tyr Lys Ala Phe Ser Ser 
        595                 600                 605             


Leu Leu Ala Ser Ser Ala Val Ser Pro Glu Lys Cys Gly Phe Gly Ala 
    610                 615                 620                 


Ser Ser Gly Glu Glu Gly Tyr Lys Pro Phe Gln Asp Leu Ile Pro Gly 
625                 630                 635                 640 


Cys Pro Gly Asp Pro Ala Pro Val Pro Val Pro Leu Phe Thr Phe Gly 
                645                 650                 655     


Leu Asp Arg Glu Pro Pro Arg Ser Pro Gln Ser Ser His Leu Pro Ser 
            660                 665                 670         


Ser Ser Pro Glu His Leu Gly Leu Glu Pro Gly Glu Lys Val Glu Asp 
        675                 680                 685             


Met Pro Lys Pro Pro Leu Pro Gln Glu Gln Ala Thr Asp Pro Leu Val 
    690                 695                 700                 


Asp Ser Leu Gly Ser Gly Ile Val Tyr Ser Ala Leu Thr Cys His Leu 
705                 710                 715                 720 


Cys Gly His Leu Lys Gln Cys His Gly Gln Glu Asp Gly Gly Gln Thr 
                725                 730                 735     


Pro Val Met Ala Ser Pro Cys Cys Gly Cys Cys Cys Gly Asp Arg Ser 
            740                 745                 750         


Ser Pro Pro Thr Thr Pro Leu Arg Ala Pro Asp Pro Ser Pro Gly Gly 
        755                 760                 765             


Val Pro Leu Glu Ala Ser Leu Cys Pro Ala Ser Leu Ala Pro Ser Gly 
    770                 775                 780                 


Ile Ser Glu Lys Ser Lys Ser Ser Ser Ser Phe His Pro Ala Pro Gly 
785                 790                 795                 800 


Asn Ala Gln Ser Ser Ser Gln Thr Pro Lys Ile Val Asn Phe Val Ser 
                805                 810                 815     


Val Gly Pro Thr Tyr Met Arg Val Ser 
            820                 825 


<210>  65
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Ala Thr Ser Arg Tyr Glu Pro Val Ala Glu Ile Gly Val Gly Ala 
1               5                   10                  15      


Tyr Gly Thr Val Tyr Lys Ala Arg Asp Pro His Ser Gly His Phe Val 
            20                  25                  30          


Ala Leu Lys Ser Val Arg Val Pro Asn Gly Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Leu Pro Ile Ser Thr Val Arg Glu Val Ala Leu Leu Arg Arg Leu Glu 
    50                  55                  60                  


Ala Phe Glu His Pro Asn Val Val Arg Leu Met Asp Val Cys Ala Thr 
65                  70                  75                  80  


Ser Arg Thr Asp Arg Glu Ile Lys Val Thr Leu Val Phe Glu His Val 
                85                  90                  95      


Asp Gln Asp Leu Arg Thr Tyr Leu Asp Lys Ala Pro Pro Pro Gly Leu 
            100                 105                 110         


Pro Ala Glu Thr Ile Lys Asp Leu Met Arg Gln Phe Leu Arg Gly Leu 
        115                 120                 125             


Asp Phe Leu His Ala Asn Cys Ile Val His Arg Asp Leu Lys Pro Glu 
    130                 135                 140                 


Asn Ile Leu Val Thr Ser Gly Gly Thr Val Lys Leu Ala Asp Phe Gly 
145                 150                 155                 160 


Leu Ala Arg Ile Tyr Ser Tyr Gln Met Ala Leu Thr Pro Val Val Val 
                165                 170                 175     


Thr Leu Trp Tyr Arg Ala Pro Glu Val Leu Leu Gln Ser Thr Tyr Ala 
            180                 185                 190         


Thr Pro Val Asp Met Trp Ser Val Gly Cys Ile Phe Ala Glu Met Phe 
        195                 200                 205             


Arg Arg Lys Pro Leu Phe Cys Gly Asn Ser Glu Ala Asp Gln Leu Gly 
    210                 215                 220                 


Lys Ile Phe Asp Leu Ile Gly Leu Pro Pro Glu Asp Asp Trp Pro Arg 
225                 230                 235                 240 


Asp Val Ser Leu Pro Arg Gly Ala Phe Pro Pro Arg Gly Pro Arg Pro 
                245                 250                 255     


Val Gln Ser Val Val Pro Glu Met Glu Glu Ser Gly Ala Gln Leu Leu 
            260                 265                 270         


Leu Glu Met Leu Thr Phe Asn Pro His Lys Arg Ile Ser Ala Phe Arg 
        275                 280                 285             


Ala Leu Gln His Ser Tyr Leu His Lys Asp Glu Gly Asn Pro Glu 
    290                 295                 300             


<210>  66
<211>  773
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Lys Met Arg Gly Glu Lys Arg Arg Asp Lys Val Asn Pro Lys Ser 
1               5                   10                  15      


Ser Gln Arg Lys Leu Asn Trp Ile Pro Ser Phe Pro Thr Tyr Asp Tyr 
            20                  25                  30          


Phe Asn Gln Val Thr Leu Gln Leu Leu Asp Gly Phe Met Ile Thr Leu 
        35                  40                  45              


Ser Thr Asp Gly Val Ile Ile Cys Val Ala Glu Asn Ile Ser Ser Leu 
    50                  55                  60                  


Leu Gly His Leu Pro Ala Glu Ile Val Gly Lys Lys Leu Leu Ser Leu 
65                  70                  75                  80  


Leu Pro Asp Glu Glu Lys Asp Glu Val Tyr Gln Lys Ile Ile Leu Lys 
                85                  90                  95      


Phe Pro Leu Leu Asn Ser Glu Thr His Ile Glu Phe Cys Cys His Leu 
            100                 105                 110         


Lys Arg Gly Asn Val Glu His Gly Asp Ser Ser Ala Tyr Glu Asn Val 
        115                 120                 125             


Lys Phe Ile Val Asn Val Arg Asp Ile Cys Asn Glu Phe Pro Val Val 
    130                 135                 140                 


Phe Ser Gly Leu Phe Ser Ser His Leu Cys Ala Asp Phe Ala Ala Cys 
145                 150                 155                 160 


Val Pro Gln Glu Asp Arg Leu Tyr Leu Val Gly Asn Val Cys Ile Leu 
                165                 170                 175     


Arg Thr Gln Leu Leu Gln Gln Leu Tyr Thr Ser Lys Ala Val Ser Asp 
            180                 185                 190         


Glu Ala Val Leu Thr Gln Asp Ser Asp Glu Glu Pro Phe Val Gly Glu 
        195                 200                 205             


Leu Ser Ser Ser Gln Gly Gln Arg Gly His Thr Ser Met Lys Ala Val 
    210                 215                 220                 


Tyr Val Glu Pro Ala Ala Ala Ala Ala Ala Ala Ala Ile Ser Asp Asp 
225                 230                 235                 240 


Gln Ile Asp Ile Ala Glu Val Glu Gln Tyr Gly Pro Gln Glu Asn Val 
                245                 250                 255     


His Met Phe Val Asp Ser Asp Ser Thr Tyr Cys Ser Ser Thr Val Phe 
            260                 265                 270         


Leu Asp Thr Met Pro Glu Ser Pro Ala Leu Ser Leu Gln Asp Phe Arg 
        275                 280                 285             


Gly Glu Pro Glu Val Asn Pro Leu Tyr Arg Ala Asp Pro Val Asp Leu 
    290                 295                 300                 


Glu Phe Ser Val Asp Gln Val Asp Ser Val Asp Gln Glu Gly Pro Met 
305                 310                 315                 320 


Asp Gln Gln Asp Pro Glu Asn Pro Val Ala Pro Leu Asp Gln Ala Gly 
                325                 330                 335     


Leu Met Asp Pro Val Asp Pro Glu Asp Ser Val Asp Leu Gly Ala Ala 
            340                 345                 350         


Gly Ala Ser Ala Gln Pro Leu Gln Pro Ser Ser Pro Val Ala Tyr Asp 
        355                 360                 365             


Ile Ile Ser Gln Glu Leu Glu Leu Met Lys Lys Leu Lys Glu Gln Leu 
    370                 375                 380                 


Glu Glu Arg Thr Trp Leu Leu His Asp Ala Ile Gln Asn Gln Gln Asn 
385                 390                 395                 400 


Ala Leu Glu Leu Met Met Asp His Leu Gln Lys Gln Pro Asn Thr Leu 
                405                 410                 415     


Arg His Val Val Ile Pro Asp Leu Gln Ser Ser Glu Ala Val Pro Lys 
            420                 425                 430         


Lys Gln Gln Lys Gln His Ala Gly Gln Val Lys Arg Pro Leu Pro His 
        435                 440                 445             


Pro Lys Asp Val Lys Cys Phe Cys Gly Leu Ser Leu Ser Asn Ser Leu 
    450                 455                 460                 


Lys Asn Thr Gly Glu Leu Gln Glu Pro Cys Val Ala Phe Asn Gln Gln 
465                 470                 475                 480 


Gln Leu Val Gln Gln Glu Gln His Leu Lys Glu Gln Gln Arg Gln Leu 
                485                 490                 495     


Arg Glu Gln Leu Gln Gln Leu Arg Glu Gln Arg Lys Val Gln Lys Gln 
            500                 505                 510         


Lys Lys Met Gln Glu Lys Lys Lys Leu Gln Glu Gln Lys Met Gln Glu 
        515                 520                 525             


Lys Lys Lys Leu Gln Glu Gln Arg Arg Gln Lys Lys Lys Lys Leu Gln 
    530                 535                 540                 


Glu Arg Lys Lys Trp Gln Gly Gln Met Leu Gln Lys Glu Pro Glu Glu 
545                 550                 555                 560 


Glu Gln Gln Lys Gln Gln Leu Gln Glu Gln Pro Leu Lys His Asn Val 
                565                 570                 575     


Ile Val Gly Asn Glu Arg Val Gln Ile Cys Leu Gln Asn Pro Arg Asp 
            580                 585                 590         


Val Ser Val Pro Leu Cys Asn His Pro Val Arg Phe Leu Gln Ala Gln 
        595                 600                 605             


Pro Ile Val Pro Val Gln Arg Ala Ala Glu Gln Gln Pro Ser Gly Phe 
    610                 615                 620                 


Tyr Gln Asp Glu Asn Cys Gly Gln Gln Glu Asp Glu Ser Gln Ser Phe 
625                 630                 635                 640 


Tyr Pro Glu Ala Tyr Gln Gly Pro Pro Val Asn Gln Leu Pro Leu Ile 
                645                 650                 655     


Asp Thr Ser Asn Ser Glu Ala Ile Ser Ser Ser Ser Ile Pro Gln Phe 
            660                 665                 670         


Pro Ile Thr Ser Asp Ser Thr Ile Ser Thr Leu Glu Thr Pro Gln Asp 
        675                 680                 685             


Tyr Ile Arg Leu Trp Gln Glu Leu Ser Asp Ser Leu Gly Pro Val Val 
    690                 695                 700                 


Gln Val Asn Thr Trp Ser Cys Asp Glu Gln Gly Thr Leu His Gly Gln 
705                 710                 715                 720 


Pro Thr Tyr His Gln Val Gln Val Ser Glu Val Gly Val Glu Gly Pro 
                725                 730                 735     


Pro Asp Pro Gln Ala Phe Gln Gly Pro Ala Ala Tyr Gln Pro Asp Gln 
            740                 745                 750         


Met Arg Ser Ala Glu Gln Thr Arg Leu Met Pro Ala Glu Gln Arg Asp 
        755                 760                 765             


Ser Asn Lys Pro Cys 
    770             


<210>  67
<211>  1255
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His 
    50                  55                  60                  


Ser Pro Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu 
65                  70                  75                  80  


Ala Pro Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln 
                85                  90                  95      


Asp Val Thr Ser Val Pro Val Thr Arg Pro Ala Leu Gly Ser Thr Thr 
            100                 105                 110         


Pro Pro Ala His Asp Val Thr Ser Ala Pro Asp Asn Lys Pro Ala Pro 
        115                 120                 125             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    130                 135                 140                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
145                 150                 155                 160 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                165                 170                 175     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            180                 185                 190         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        195                 200                 205             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    210                 215                 220                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
225                 230                 235                 240 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                245                 250                 255     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            260                 265                 270         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        275                 280                 285             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    290                 295                 300                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
305                 310                 315                 320 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                325                 330                 335     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            340                 345                 350         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        355                 360                 365             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    370                 375                 380                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
385                 390                 395                 400 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                405                 410                 415     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            420                 425                 430         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        435                 440                 445             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    450                 455                 460                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
465                 470                 475                 480 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                485                 490                 495     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            500                 505                 510         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        515                 520                 525             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    530                 535                 540                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
545                 550                 555                 560 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                565                 570                 575     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            580                 585                 590         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        595                 600                 605             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    610                 615                 620                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
625                 630                 635                 640 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                645                 650                 655     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            660                 665                 670         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        675                 680                 685             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    690                 695                 700                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
705                 710                 715                 720 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                725                 730                 735     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            740                 745                 750         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        755                 760                 765             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    770                 775                 780                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
785                 790                 795                 800 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                805                 810                 815     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            820                 825                 830         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        835                 840                 845             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    850                 855                 860                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
865                 870                 875                 880 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                885                 890                 895     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            900                 905                 910         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        915                 920                 925             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Asn 
    930                 935                 940                 


Arg Pro Ala Leu Gly Ser Thr Ala Pro Pro Val His Asn Val Thr Ser 
945                 950                 955                 960 


Ala Ser Gly Ser Ala Ser Gly Ser Ala Ser Thr Leu Val His Asn Gly 
                965                 970                 975     


Thr Ser Ala Arg Ala Thr Thr Thr Pro Ala Ser Lys Ser Thr Pro Phe 
            980                 985                 990         


Ser Ile Pro Ser His His Ser Asp  Thr Pro Thr Thr Leu  Ala Ser His 
        995                 1000                 1005             


Ser Thr  Lys Thr Asp Ala Ser  Ser Thr His His Ser  Ser Val Pro 
    1010                 1015                 1020             


Pro Leu  Thr Ser Ser Asn His  Ser Thr Ser Pro Gln  Leu Ser Thr 
    1025                 1030                 1035             


Gly Val  Ser Phe Phe Phe Leu  Ser Phe His Ile Ser  Asn Leu Gln 
    1040                 1045                 1050             


Phe Asn  Ser Ser Leu Glu Asp  Pro Ser Thr Asp Tyr  Tyr Gln Glu 
    1055                 1060                 1065             


Leu Gln  Arg Asp Ile Ser Glu  Met Phe Leu Gln Ile  Tyr Lys Gln 
    1070                 1075                 1080             


Gly Gly  Phe Leu Gly Leu Ser  Asn Ile Lys Phe Arg  Pro Gly Ser 
    1085                 1090                 1095             


Val Val  Val Gln Leu Thr Leu  Ala Phe Arg Glu Gly  Thr Ile Asn 
    1100                 1105                 1110             


Val His  Asp Val Glu Thr Gln  Phe Asn Gln Tyr Lys  Thr Glu Ala 
    1115                 1120                 1125             


Ala Ser  Arg Tyr Asn Leu Thr  Ile Ser Asp Val Ser  Val Ser Asp 
    1130                 1135                 1140             


Val Pro  Phe Pro Phe Ser Ala  Gln Ser Gly Ala Gly  Val Pro Gly 
    1145                 1150                 1155             


Trp Gly  Ile Ala Leu Leu Val  Leu Val Cys Val Leu  Val Ala Leu 
    1160                 1165                 1170             


Ala Ile  Val Tyr Leu Ile Ala  Leu Ala Val Cys Gln  Cys Arg Arg 
    1175                 1180                 1185             


Lys Asn  Tyr Gly Gln Leu Asp  Ile Phe Pro Ala Arg  Asp Thr Tyr 
    1190                 1195                 1200             


His Pro  Met Ser Glu Tyr Pro  Thr Tyr His Thr His  Gly Arg Tyr 
    1205                 1210                 1215             


Val Pro  Pro Ser Ser Thr Asp  Arg Ser Pro Tyr Glu  Lys Val Ser 
    1220                 1225                 1230             


Ala Gly  Asn Gly Gly Ser Ser  Leu Ser Tyr Thr Asn  Pro Ala Val 
    1235                 1240                 1245             


Ala Ala  Thr Ser Ala Asn Leu  
    1250                 1255 


<210>  68
<211>  937
<212>  PRT
<213>  Homo sapiens

<400>  68

Met His Arg Pro Arg Arg Arg Gly Thr Arg Pro Pro Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Ala Leu Leu Leu Ala Ala Arg Gly Ala Ala Ala Gln Glu Thr 
            20                  25                  30          


Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser Trp Asn Ile 
        35                  40                  45              


Ser Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp Glu Pro Met 
    50                  55                  60                  


Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu His Cys Lys 
65                  70                  75                  80  


Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys Asn Asp Ala 
                85                  90                  95      


Pro Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser Thr Ile Tyr 
            100                 105                 110         


Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp Thr Gly Tyr 
        115                 120                 125             


Phe Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser Ser Thr Gly 
    130                 135                 140                 


Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser Pro Gly Tyr 
145                 150                 155                 160 


Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr Arg Gly Ile 
                165                 170                 175     


Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met Glu Ser Leu 
            180                 185                 190         


His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala Phe Thr Met 
        195                 200                 205             


Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln Phe Ala Ile 
    210                 215                 220                 


Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu Thr Ser Ser 
225                 230                 235                 240 


Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu Ile Leu Glu 
                245                 250                 255     


Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser Asn Pro Met 
            260                 265                 270         


Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu Pro Gln Pro 
        275                 280                 285             


Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile Pro Met Ala 
    290                 295                 300                 


Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr Gly Val Asp 
305                 310                 315                 320 


Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln Cys Gln Pro 
                325                 330                 335     


Trp Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala Leu Arg Phe 
            340                 345                 350         


Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro Gly Asn Gln 
        355                 360                 365             


Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe Lys Ser Asp 
    370                 375                 380                 


Leu Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Lys Glu Lys Asn 
385                 390                 395                 400 


Lys Met Glu Ile Leu Tyr Ile Leu Val Pro Ser Val Ala Ile Pro Leu 
                405                 410                 415     


Ala Ile Ala Leu Leu Phe Phe Phe Ile Cys Val Cys Arg Asn Asn Gln 
            420                 425                 430         


Lys Ser Ser Ser Ala Pro Val Gln Arg Gln Pro Lys His Val Arg Gly 
        435                 440                 445             


Gln Asn Val Glu Met Ser Met Leu Asn Ala Tyr Lys Pro Lys Ser Lys 
    450                 455                 460                 


Ala Lys Glu Leu Pro Leu Ser Ala Val Arg Phe Met Glu Glu Leu Gly 
465                 470                 475                 480 


Glu Cys Ala Phe Gly Lys Ile Tyr Lys Gly His Leu Tyr Leu Pro Gly 
                485                 490                 495     


Met Asp His Ala Gln Leu Val Ala Ile Lys Thr Leu Lys Asp Tyr Asn 
            500                 505                 510         


Asn Pro Gln Gln Trp Thr Glu Phe Gln Gln Glu Ala Ser Leu Met Ala 
        515                 520                 525             


Glu Leu His His Pro Asn Ile Val Cys Leu Leu Gly Ala Val Thr Gln 
    530                 535                 540                 


Glu Gln Pro Val Cys Met Leu Phe Glu Tyr Ile Asn Gln Gly Asp Leu 
545                 550                 555                 560 


His Glu Phe Leu Ile Met Arg Ser Pro His Ser Asp Val Gly Cys Ser 
                565                 570                 575     


Ser Asp Glu Asp Gly Thr Val Lys Ser Ser Leu Asp His Gly Asp Phe 
            580                 585                 590         


Leu His Ile Ala Ile Gln Ile Ala Ala Gly Met Glu Tyr Leu Ser Ser 
        595                 600                 605             


His Phe Phe Val His Lys Asp Leu Ala Ala Arg Asn Ile Leu Ile Gly 
    610                 615                 620                 


Glu Gln Leu His Val Lys Ile Ser Asp Leu Gly Leu Ser Arg Glu Ile 
625                 630                 635                 640 


Tyr Ser Ala Asp Tyr Tyr Arg Val Gln Ser Lys Ser Leu Leu Pro Ile 
                645                 650                 655     


Arg Trp Met Pro Pro Glu Ala Ile Met Tyr Gly Lys Phe Ser Ser Asp 
            660                 665                 670         


Ser Asp Ile Trp Ser Phe Gly Val Val Leu Trp Glu Ile Phe Ser Phe 
        675                 680                 685             


Gly Leu Gln Pro Tyr Tyr Gly Phe Ser Asn Gln Glu Val Ile Glu Met 
    690                 695                 700                 


Val Arg Lys Arg Gln Leu Leu Pro Cys Ser Glu Asp Cys Pro Pro Arg 
705                 710                 715                 720 


Met Tyr Ser Leu Met Thr Glu Cys Trp Asn Glu Ile Pro Ser Arg Arg 
                725                 730                 735     


Pro Arg Phe Lys Asp Ile His Val Arg Leu Arg Ser Trp Glu Gly Leu 
            740                 745                 750         


Ser Ser His Thr Ser Ser Thr Thr Pro Ser Gly Gly Asn Ala Thr Thr 
        755                 760                 765             


Gln Thr Thr Ser Leu Ser Ala Ser Pro Val Ser Asn Leu Ser Asn Pro 
    770                 775                 780                 


Arg Tyr Pro Asn Tyr Met Phe Pro Ser Gln Gly Ile Thr Pro Gln Gly 
785                 790                 795                 800 


Gln Ile Ala Gly Phe Ile Gly Pro Pro Ile Pro Gln Asn Gln Arg Phe 
                805                 810                 815     


Ile Pro Ile Asn Gly Tyr Pro Ile Pro Pro Gly Tyr Ala Ala Phe Pro 
            820                 825                 830         


Ala Ala His Tyr Gln Pro Thr Gly Pro Pro Arg Val Ile Gln His Cys 
        835                 840                 845             


Pro Pro Pro Lys Ser Arg Ser Pro Ser Ser Ala Ser Gly Ser Thr Ser 
    850                 855                 860                 


Thr Gly His Val Thr Ser Leu Pro Ser Ser Gly Ser Asn Gln Glu Ala 
865                 870                 875                 880 


Asn Ile Pro Leu Leu Pro His Met Ser Ile Pro Asn His Pro Gly Gly 
                885                 890                 895     


Met Gly Ile Thr Val Phe Gly Asn Lys Ser Gln Lys Pro Tyr Lys Ile 
            900                 905                 910         


Asp Ser Lys Gln Ala Ser Leu Leu Gly Asp Ala Asn Ile His Gly His 
        915                 920                 925             


Thr Glu Ser Met Ile Ser Ala Glu Leu 
    930                 935         


<210>  69
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  69

Met His Gly Pro Arg Glu Thr Leu Gln Glu Ile Val Leu His Leu Glu 
1               5                   10                  15      


Pro Gln Asn Glu Leu Asp Pro Val Asp Leu Leu Cys Tyr Glu Gln Leu 
            20                  25                  30          


Ser Glu Ser Glu Glu Glu Asn Asp Glu Ala Asp Gly Val Ser His Ala 
        35                  40                  45              


Gln Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Lys Ile Leu Cys 
    50                  55                  60                  


Val Cys Cys Lys Cys Asp Gly Arg Ile Glu Leu Thr Val Glu Ser Ser 
65                  70                  75                  80  


Ala Glu Asp Leu Arg Thr Leu Gln Gln Leu Phe Leu Ser Thr Leu Ser 
                85                  90                  95      


Phe Val Cys Pro Trp Cys Ala Thr Asn Gln 
            100                 105     


<210>  70
<211>  979
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Asp Asn Tyr Leu Ser Thr Asp Val 
            20                  25                  30          


Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln Glu Val Thr Ala 
        35                  40                  45              


Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys Pro Cys Ala Arg 
    50                  55                  60                  


Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu Val Arg Ala Val 
65                  70                  75                  80  


Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys Lys Ile Phe Gly 
                85                  90                  95      


Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp Pro Ala Ser Asn 
            100                 105                 110         


Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe Glu Thr Leu Glu 
        115                 120                 125             


Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Asp Ser Leu Pro 
    130                 135                 140                 


Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg Gly Arg Ile Leu 
145                 150                 155                 160 


His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly Ile Ser Trp 
                165                 170                 175     


Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu Ala Leu Ile 
            180                 185                 190         


His His Asn Thr His Leu Cys Phe Val His Thr Val Pro Trp Asp Gln 
        195                 200                 205             


Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr Ala Asn Arg Pro 
    210                 215                 220                 


Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His Gln Leu Cys Ala 
225                 230                 235                 240 


Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys Val Asn Cys Ser 
                245                 250                 255     


Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys Arg Val Leu Gln 
            260                 265                 270         


Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys Leu Pro Cys His 
        275                 280                 285             


Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys Phe Gly Pro Glu 
    290                 295                 300                 


Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp Pro Pro Phe Cys 
305                 310                 315                 320 


Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Tyr Met Pro 
                325                 330                 335     


Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln Pro Cys Pro Ile 
            340                 345                 350         


Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys Gly Cys Pro Ala 
        355                 360                 365             


Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser Ala Val Val Gly 
    370                 375                 380                 


Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly Ile Leu Ile Lys 
385                 390                 395                 400 


Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg Arg Leu Leu Gln 
                405                 410                 415     


Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Ala Met Pro Asn 
            420                 425                 430         


Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu Arg Lys Val Lys 
        435                 440                 445             


Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile Trp Ile 
    450                 455                 460                 


Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile Lys Val Leu Arg 
465                 470                 475                 480 


Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr 
                485                 490                 495     


Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg Leu Leu Gly Ile 
            500                 505                 510         


Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu Met Pro Tyr Gly 
        515                 520                 525             


Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg Leu Gly Ser Gln 
    530                 535                 540                 


Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly Met Ser Tyr Leu 
545                 550                 555                 560 


Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu 
                565                 570                 575     


Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe Gly Leu Ala Arg 
            580                 585                 590         


Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp Gly Gly Lys Val 
        595                 600                 605             


Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg Arg Arg Phe Thr 
    610                 615                 620                 


His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met 
625                 630                 635                 640 


Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala Arg Glu Ile Pro 
                645                 650                 655     


Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr 
            660                 665                 670         


Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met Ile Asp Ser Glu 
        675                 680                 685             


Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe Ser Arg Met Ala 
    690                 695                 700                 


Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu Asp Leu Gly Pro 
705                 710                 715                 720 


Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg Ser Leu Leu Glu Asp Asp 
                725                 730                 735     


Asp Met Gly Asp Leu Val Asp Ala Glu Glu Tyr Leu Val Pro Gln Gln 
            740                 745                 750         


Gly Phe Phe Cys Pro Asp Pro Ala Pro Gly Ala Gly Gly Met Val His 
        755                 760                 765             


His Arg His Arg Ser Ser Ser Thr Arg Ser Gly Gly Gly Asp Leu Thr 
    770                 775                 780                 


Leu Gly Leu Glu Pro Ser Glu Glu Glu Ala Pro Arg Ser Pro Leu Ala 
785                 790                 795                 800 


Pro Ser Glu Gly Ala Gly Ser Asp Val Phe Asp Gly Asp Leu Gly Met 
                805                 810                 815     


Gly Ala Ala Lys Gly Leu Gln Ser Leu Pro Thr His Asp Pro Ser Pro 
            820                 825                 830         


Leu Gln Arg Tyr Ser Glu Asp Pro Thr Val Pro Leu Pro Ser Glu Thr 
        835                 840                 845             


Asp Gly Tyr Val Ala Pro Leu Thr Cys Ser Pro Gln Pro Glu Tyr Val 
    850                 855                 860                 


Asn Gln Pro Asp Val Arg Pro Gln Pro Pro Ser Pro Arg Glu Gly Pro 
865                 870                 875                 880 


Leu Pro Ala Ala Arg Pro Ala Gly Ala Thr Leu Glu Arg Pro Lys Thr 
                885                 890                 895     


Leu Ser Pro Gly Lys Asn Gly Val Val Lys Asp Val Phe Ala Phe Gly 
            900                 905                 910         


Gly Ala Val Glu Asn Pro Glu Tyr Leu Thr Pro Gln Gly Gly Ala Ala 
        915                 920                 925             


Pro Gln Pro His Pro Pro Pro Ala Phe Ser Pro Ala Phe Asp Asn Leu 
    930                 935                 940                 


Tyr Tyr Trp Asp Gln Asp Pro Pro Glu Arg Gly Ala Pro Pro Ser Thr 
945                 950                 955                 960 


Phe Lys Gly Thr Pro Thr Ala Glu Asn Pro Glu Tyr Leu Gly Leu Asp 
                965                 970                 975     


Val Pro Val 
            


<210>  71
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Ser Lys Val Ile Lys Lys Arg Val Glu Thr Ser Pro Arg Pro Thr 
1               5                   10                  15      


Ala Ser Ser Asp Ser Leu Gln Thr Cys Ala Gly Val Ile Glu Tyr Ala 
            20                  25                  30          


Lys Ser Ile Ser Lys Ser Asn Ala Lys Cys Ile Glu Tyr Val Thr Leu 
        35                  40                  45              


Asn Ala Ser Gln Tyr Ala Asn Cys Ser Ser Ile Ser Ile Lys Leu Thr 
    50                  55                  60                  


Asp Ser Leu Ser Ser Gln Met Thr Ser Thr Phe Ile Met Leu Glu Gly 
65                  70                  75                  80  


Glu Thr Lys Leu Tyr Lys Asn Lys Ser Lys Gln Asp Arg Ser Asp Gly 
                85                  90                  95      


Tyr Phe Leu Lys Ile Lys Val Thr Ala Ala Ser Pro Met Leu Tyr Gln 
            100                 105                 110         


Leu Leu Glu Ala Val Tyr Gly Asn Ile Lys His Lys Glu Arg Ile Pro 
        115                 120                 125             


Asn Ser Leu His Ser Leu Ser Val Glu Thr Ile Thr Glu Lys Thr Phe 
    130                 135                 140                 


Lys Asp Glu Ser Ile Phe Ile Asn Lys Leu Asn Gly Ala Met Val Glu 
145                 150                 155                 160 


Tyr Val Ser Ala Gly Glu Ser Ser Ile Leu Arg Ser Ile Glu Gly Glu 
                165                 170                 175     


Leu Glu Ser Leu Ser Lys Arg Glu Arg Gln Leu Ala Lys Ala Ile Ile 
            180                 185                 190         


Thr Pro Ile Val Phe Tyr Arg Ser Gly Thr Glu Thr Lys Ile Thr Phe 
        195                 200                 205             


Ala Leu Lys Lys Leu Ile Ile Asp Arg Glu Val Val Ala Asn Val Ile 
    210                 215                 220                 


Gly Leu Ser Gly Asp Ser Glu Arg Val Ser Met Thr Glu Asn Val Glu 
225                 230                 235                 240 


Glu Asp Leu Ala Arg Asn Leu Gly Leu Val Asp Ile Asp Asp Glu Tyr 
                245                 250                 255     


Asp Glu Asp Ser Asp Lys Glu Lys Pro Ile Phe Asn Val 
            260                 265                 


<210>  72
<211>  580
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Ala Gly Thr Val Arg Thr Ala Cys Leu Val Val Ala Met Leu Leu 
1               5                   10                  15      


Ser Leu Asp Phe Pro Gly Gln Ala Gln Pro Pro Pro Pro Pro Pro Asp 
            20                  25                  30          


Ala Thr Cys His Gln Val Arg Ser Phe Phe Gln Arg Leu Gln Pro Gly 
        35                  40                  45              


Leu Lys Trp Val Pro Glu Thr Pro Val Pro Gly Ser Asp Leu Gln Val 
    50                  55                  60                  


Cys Leu Pro Lys Gly Pro Thr Cys Cys Ser Arg Lys Met Glu Glu Lys 
65                  70                  75                  80  


Tyr Gln Leu Thr Ala Arg Leu Asn Met Glu Gln Leu Leu Gln Ser Ala 
                85                  90                  95      


Ser Met Glu Leu Lys Phe Leu Ile Ile Gln Asn Ala Ala Val Phe Gln 
            100                 105                 110         


Glu Ala Phe Glu Ile Val Val Arg His Ala Lys Asn Tyr Thr Asn Ala 
        115                 120                 125             


Met Phe Lys Asn Asn Tyr Pro Ser Leu Thr Pro Gln Ala Phe Glu Phe 
    130                 135                 140                 


Val Gly Glu Phe Phe Thr Asp Val Ser Leu Tyr Ile Leu Gly Ser Asp 
145                 150                 155                 160 


Ile Asn Val Asp Asp Met Val Asn Glu Leu Phe Asp Ser Leu Phe Pro 
                165                 170                 175     


Val Ile Tyr Thr Gln Leu Met Asn Pro Gly Leu Pro Asp Ser Ala Leu 
            180                 185                 190         


Asp Ile Asn Glu Cys Leu Arg Gly Ala Arg Arg Asp Leu Lys Val Phe 
        195                 200                 205             


Gly Asn Phe Pro Lys Leu Ile Met Thr Gln Val Ser Lys Ser Leu Gln 
    210                 215                 220                 


Val Thr Arg Ile Phe Leu Gln Ala Leu Asn Leu Gly Ile Glu Val Ile 
225                 230                 235                 240 


Asn Thr Thr Asp His Leu Lys Phe Ser Lys Asp Cys Gly Arg Met Leu 
                245                 250                 255     


Thr Arg Met Trp Tyr Cys Ser Tyr Cys Gln Gly Leu Met Met Val Lys 
            260                 265                 270         


Pro Cys Gly Gly Tyr Cys Asn Val Val Met Gln Gly Cys Met Ala Gly 
        275                 280                 285             


Val Val Glu Ile Asp Lys Tyr Trp Arg Glu Tyr Ile Leu Ser Leu Glu 
    290                 295                 300                 


Glu Leu Val Asn Gly Met Tyr Arg Ile Tyr Asp Met Glu Asn Val Leu 
305                 310                 315                 320 


Leu Gly Leu Phe Ser Thr Ile His Asp Ser Ile Gln Tyr Val Gln Lys 
                325                 330                 335     


Asn Ala Gly Lys Leu Thr Thr Thr Ile Gly Lys Leu Cys Ala His Ser 
            340                 345                 350         


Gln Gln Arg Gln Tyr Arg Ser Ala Tyr Tyr Pro Glu Asp Leu Phe Ile 
        355                 360                 365             


Asp Lys Lys Val Leu Lys Val Ala His Val Glu His Glu Glu Thr Leu 
    370                 375                 380                 


Ser Ser Arg Arg Arg Glu Leu Ile Gln Lys Leu Lys Ser Phe Ile Ser 
385                 390                 395                 400 


Phe Tyr Ser Ala Leu Pro Gly Tyr Ile Cys Ser His Ser Pro Val Ala 
                405                 410                 415     


Glu Asn Asp Thr Leu Cys Trp Asn Gly Gln Glu Leu Val Glu Arg Tyr 
            420                 425                 430         


Ser Gln Lys Ala Ala Arg Asn Gly Met Lys Asn Gln Phe Asn Leu His 
        435                 440                 445             


Glu Leu Lys Met Lys Gly Pro Glu Pro Val Val Ser Gln Ile Ile Asp 
    450                 455                 460                 


Lys Leu Lys His Ile Asn Gln Leu Leu Arg Thr Met Ser Met Pro Lys 
465                 470                 475                 480 


Gly Arg Val Leu Asp Lys Asn Leu Asp Glu Glu Gly Phe Glu Ser Gly 
                485                 490                 495     


Asp Cys Gly Asp Asp Glu Asp Glu Cys Ile Gly Gly Ser Gly Asp Gly 
            500                 505                 510         


Met Ile Lys Val Lys Asn Gln Leu Arg Phe Leu Ala Glu Leu Ala Tyr 
        515                 520                 525             


Asp Leu Asp Val Asp Asp Ala Pro Gly Asn Ser Gln Gln Ala Thr Pro 
    530                 535                 540                 


Lys Asp Asn Glu Ile Ser Thr Phe His Asn Leu Gly Asn Val His Ser 
545                 550                 555                 560 


Pro Leu Lys Leu Leu Thr Ser Met Ala Ile Ser Val Val Cys Phe Phe 
                565                 570                 575     


Phe Leu Val His 
            580 


<210>  73
<211>  2000
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Lys Ala Ala Asp Thr Val Ile Leu Trp Ala Arg Ser Lys Asn Asp 
1               5                   10                  15      


Gln Leu Arg Ile Ser Phe Pro Pro Gly Leu Cys Trp Gly Asp Arg Met 
            20                  25                  30          


Pro Asp Lys Asp Asp Ile Arg Leu Leu Pro Ser Ala Leu Gly Val Lys 
        35                  40                  45              


Lys Arg Lys Arg Gly Pro Lys Lys Gln Lys Glu Asn Lys Pro Gly Lys 
    50                  55                  60                  


Pro Arg Lys Arg Lys Lys Arg Asp Ser Glu Glu Glu Phe Gly Ser Glu 
65                  70                  75                  80  


Arg Asp Glu Tyr Arg Glu Lys Ser Glu Ser Gly Gly Ser Glu Tyr Gly 
                85                  90                  95      


Thr Gly Pro Gly Arg Lys Arg Arg Arg Lys His Arg Glu Lys Lys Glu 
            100                 105                 110         


Lys Lys Thr Lys Arg Arg Lys Lys Gly Glu Gly Asp Gly Gly Gln Lys 
        115                 120                 125             


Gln Val Glu Gln Lys Ser Ser Ala Thr Leu Leu Leu Thr Trp Gly Leu 
    130                 135                 140                 


Glu Asp Val Glu His Val Phe Ser Glu Glu Asp Tyr His Thr Leu Thr 
145                 150                 155                 160 


Asn Tyr Lys Ala Phe Ser Gln Phe Met Arg Pro Leu Ile Ala Lys Lys 
                165                 170                 175     


Asn Pro Lys Ile Pro Met Ser Lys Met Met Thr Ile Leu Gly Ala Lys 
            180                 185                 190         


Trp Arg Glu Phe Ser Ala Asn Asn Pro Phe Lys Gly Ser Ala Ala Ala 
        195                 200                 205             


Val Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Ala Glu Gln Val 
    210                 215                 220                 


Ser Ala Ala Val Ser Ser Ala Thr Pro Ile Ala Pro Ser Gly Pro Pro 
225                 230                 235                 240 


Ala Leu Pro Pro Pro Pro Ala Ala Asp Ile Gln Pro Pro Pro Ile Arg 
                245                 250                 255     


Arg Ala Lys Thr Lys Glu Gly Lys Gly Pro Gly His Lys Arg Arg Ser 
            260                 265                 270         


Lys Ser Pro Arg Val Pro Asp Gly Arg Lys Lys Leu Arg Gly Lys Lys 
        275                 280                 285             


Met Ala Pro Leu Lys Ile Lys Leu Gly Leu Leu Gly Gly Lys Arg Lys 
    290                 295                 300                 


Lys Gly Gly Ser Tyr Val Phe Gln Ser Asp Glu Gly Pro Glu Pro Glu 
305                 310                 315                 320 


Ala Glu Glu Ser Asp Leu Asp Ser Gly Ser Val His Ser Ala Ser Gly 
                325                 330                 335     


Arg Pro Asp Gly Pro Val Arg Thr Lys Lys Leu Lys Arg Gly Arg Pro 
            340                 345                 350         


Gly Arg Lys Lys Lys Lys Val Leu Gly Cys Pro Ala Val Ala Gly Glu 
        355                 360                 365             


Glu Glu Val Asp Gly Tyr Glu Thr Asp His Gln Asp Tyr Cys Glu Val 
    370                 375                 380                 


Cys Gln Gln Gly Gly Glu Ile Ile Leu Cys Asp Thr Cys Pro Arg Ala 
385                 390                 395                 400 


Tyr His Leu Val Cys Leu Asp Pro Glu Leu Asp Arg Ala Pro Glu Gly 
                405                 410                 415     


Lys Trp Ser Cys Pro His Cys Glu Lys Glu Gly Val Gln Trp Glu Ala 
            420                 425                 430         


Lys Glu Glu Glu Glu Glu Tyr Glu Glu Glu Gly Glu Glu Glu Gly Glu 
        435                 440                 445             


Lys Glu Glu Glu Asp Asp His Met Glu Tyr Cys Arg Val Cys Lys Asp 
    450                 455                 460                 


Gly Gly Glu Leu Leu Cys Cys Asp Ala Cys Ile Ser Ser Tyr His Ile 
465                 470                 475                 480 


His Cys Leu Asn Pro Pro Leu Pro Asp Ile Pro Asn Gly Glu Trp Leu 
                485                 490                 495     


Cys Pro Arg Cys Thr Cys Pro Val Leu Lys Gly Arg Val Gln Lys Ile 
            500                 505                 510         


Leu His Trp Arg Trp Gly Glu Pro Pro Val Ala Val Pro Ala Pro Gln 
        515                 520                 525             


Gln Ala Asp Gly Asn Pro Asp Val Pro Pro Pro Arg Pro Leu Gln Gly 
    530                 535                 540                 


Arg Ser Glu Arg Glu Phe Phe Val Lys Trp Val Gly Leu Ser Tyr Trp 
545                 550                 555                 560 


His Cys Ser Trp Ala Lys Glu Leu Gln Leu Glu Ile Phe His Leu Val 
                565                 570                 575     


Met Tyr Arg Asn Tyr Gln Arg Lys Asn Asp Met Asp Glu Pro Pro Pro 
            580                 585                 590         


Leu Asp Tyr Gly Ser Gly Glu Asp Asp Gly Lys Ser Asp Lys Arg Lys 
        595                 600                 605             


Val Lys Asp Pro His Tyr Ala Glu Met Glu Glu Lys Tyr Tyr Arg Phe 
    610                 615                 620                 


Gly Ile Lys Pro Glu Trp Met Thr Val His Arg Ile Ile Asn His Ser 
625                 630                 635                 640 


Val Asp Lys Lys Gly Asn Tyr His Tyr Leu Val Lys Trp Arg Asp Leu 
                645                 650                 655     


Pro Tyr Asp Gln Ser Thr Trp Glu Glu Asp Glu Met Asn Ile Pro Glu 
            660                 665                 670         


Tyr Glu Glu His Lys Gln Ser Tyr Trp Arg His Arg Glu Leu Ile Met 
        675                 680                 685             


Gly Glu Asp Pro Ala Gln Pro Arg Lys Tyr Lys Lys Lys Lys Lys Glu 
    690                 695                 700                 


Leu Gln Gly Asp Gly Pro Pro Ser Ser Pro Thr Asn Asp Pro Thr Val 
705                 710                 715                 720 


Lys Tyr Glu Thr Gln Pro Arg Phe Ile Thr Ala Thr Gly Gly Thr Leu 
                725                 730                 735     


His Met Tyr Gln Leu Glu Gly Leu Asn Trp Leu Arg Phe Ser Trp Ala 
            740                 745                 750         


Gln Gly Thr Asp Thr Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Thr 
        755                 760                 765             


Ile Gln Thr Ile Val Phe Leu Tyr Ser Leu Tyr Lys Glu Gly His Thr 
    770                 775                 780                 


Lys Gly Pro Phe Leu Val Ser Ala Pro Leu Ser Thr Ile Ile Asn Trp 
785                 790                 795                 800 


Glu Arg Glu Phe Gln Met Trp Ala Pro Lys Phe Tyr Val Val Thr Tyr 
                805                 810                 815     


Thr Gly Asp Lys Asp Ser Arg Ala Ile Ile Arg Glu Asn Glu Phe Ser 
            820                 825                 830         


Phe Glu Asp Asn Ala Ile Lys Gly Gly Lys Lys Ala Phe Lys Met Lys 
        835                 840                 845             


Arg Glu Ala Gln Val Lys Phe His Val Leu Leu Thr Ser Tyr Glu Leu 
    850                 855                 860                 


Ile Thr Ile Asp Gln Ala Ala Leu Gly Ser Ile Arg Trp Ala Cys Leu 
865                 870                 875                 880 


Val Val Asp Glu Ala His Arg Leu Lys Asn Asn Gln Ser Lys Phe Phe 
                885                 890                 895     


Arg Val Leu Asn Gly Tyr Lys Ile Asp His Lys Leu Leu Leu Thr Gly 
            900                 905                 910         


Thr Pro Leu Gln Asn Asn Leu Glu Glu Leu Phe His Leu Leu Asn Phe 
        915                 920                 925             


Leu Thr Pro Glu Arg Phe Asn Asn Leu Glu Gly Phe Leu Glu Glu Phe 
    930                 935                 940                 


Ala Asp Ile Ser Lys Glu Asp Gln Ile Lys Lys Leu His Asp Leu Leu 
945                 950                 955                 960 


Gly Pro His Met Leu Arg Arg Leu Lys Ala Asp Val Phe Lys Asn Met 
                965                 970                 975     


Pro Ala Lys Thr Glu Leu Ile Val Arg Val Glu Leu Ser Pro Met Gln 
            980                 985                 990         


Lys Lys Tyr Tyr Lys Tyr Ile Leu  Thr Arg Asn Phe Glu  Ala Leu Asn 
        995                 1000                 1005             


Ser Arg  Gly Gly Gly Asn Gln  Val Ser Leu Leu Asn  Ile Met Met 
    1010                 1015                 1020             


Asp Leu  Lys Lys Cys Cys Asn  His Pro Tyr Leu Phe  Pro Val Ala 
    1025                 1030                 1035             


Ala Met  Glu Ser Pro Lys Leu  Pro Ser Gly Ala Tyr  Glu Gly Gly 
    1040                 1045                 1050             


Ala Leu  Ile Lys Ser Ser Gly  Lys Leu Met Leu Leu  Gln Lys Met 
    1055                 1060                 1065             


Leu Arg  Lys Leu Lys Glu Gln  Gly His Arg Val Leu  Ile Phe Ser 
    1070                 1075                 1080             


Gln Met  Thr Lys Met Leu Asp  Leu Leu Glu Asp Phe  Leu Asp Tyr 
    1085                 1090                 1095             


Glu Gly  Tyr Lys Tyr Glu Arg  Ile Asp Gly Gly Ile  Thr Gly Ala 
    1100                 1105                 1110             


Leu Arg  Gln Glu Ala Ile Asp  Arg Phe Asn Ala Pro  Gly Ala Gln 
    1115                 1120                 1125             


Gln Phe  Cys Phe Leu Leu Ser  Thr Arg Ala Gly Gly  Leu Gly Ile 
    1130                 1135                 1140             


Asn Leu  Ala Thr Ala Asp Thr  Val Ile Ile Phe Asp  Ser Asp Trp 
    1145                 1150                 1155             


Asn Pro  His Asn Asp Ile Gln  Ala Phe Ser Arg Ala  His Arg Ile 
    1160                 1165                 1170             


Gly Gln  Ala Asn Lys Val Met  Ile Tyr Arg Phe Val  Thr Arg Ala 
    1175                 1180                 1185             


Ser Val  Glu Glu Arg Ile Thr  Gln Val Ala Lys Arg  Lys Met Met 
    1190                 1195                 1200             


Leu Thr  His Leu Val Val Arg  Pro Gly Leu Gly Ser  Lys Ala Gly 
    1205                 1210                 1215             


Ser Met  Ser Lys Gln Glu Leu  Asp Asp Ile Leu Lys  Phe Gly Thr 
    1220                 1225                 1230             


Glu Glu  Leu Phe Lys Asp Glu  Asn Glu Gly Glu Asn  Lys Glu Glu 
    1235                 1240                 1245             


Asp Ser  Ser Val Ile His Tyr  Asp Asn Glu Ala Ile  Ala Arg Leu 
    1250                 1255                 1260             


Leu Asp  Arg Asn Gln Asp Ala  Thr Glu Asp Thr Asp  Val Gln Asn 
    1265                 1270                 1275             


Met Asn  Glu Tyr Leu Ser Ser  Phe Lys Val Ala Gln  Tyr Val Val 
    1280                 1285                 1290             


Arg Glu  Glu Asp Lys Ile Glu  Glu Ile Glu Arg Glu  Ile Ile Lys 
    1295                 1300                 1305             


Gln Glu  Glu Asn Val Asp Pro  Asp Tyr Trp Glu Lys  Leu Leu Arg 
    1310                 1315                 1320             


His His  Tyr Glu Gln Gln Gln  Glu Asp Leu Ala Arg  Asn Leu Gly 
    1325                 1330                 1335             


Lys Gly  Lys Arg Val Arg Lys  Gln Val Asn Tyr Asn  Asp Ala Ala 
    1340                 1345                 1350             


Gln Glu  Asp Gln Asp Asn Gln  Ser Glu Tyr Ser Val  Gly Ser Glu 
    1355                 1360                 1365             


Glu Glu  Asp Glu Asp Phe Asp  Glu Arg Pro Glu Gly  Arg Arg Gln 
    1370                 1375                 1380             


Ser Lys  Arg Gln Leu Arg Asn  Glu Lys Asp Lys Pro  Leu Pro Pro 
    1385                 1390                 1395             


Leu Leu  Ala Arg Val Gly Gly  Asn Ile Glu Val Leu  Gly Phe Asn 
    1400                 1405                 1410             


Thr Arg  Gln Arg Lys Ala Phe  Leu Asn Ala Val Met  Arg Trp Gly 
    1415                 1420                 1425             


Met Pro  Pro Gln Asp Ala Phe  Thr Thr Gln Trp Leu  Val Arg Asp 
    1430                 1435                 1440             


Leu Arg  Gly Lys Thr Glu Lys  Glu Phe Lys Ala Tyr  Val Ser Leu 
    1445                 1450                 1455             


Phe Met  Arg His Leu Cys Glu  Pro Gly Ala Asp Gly  Ser Glu Thr 
    1460                 1465                 1470             


Phe Ala  Asp Gly Val Pro Arg  Glu Gly Leu Ser Arg  Gln Gln Val 
    1475                 1480                 1485             


Leu Thr  Arg Ile Gly Val Met  Ser Leu Val Lys Lys  Lys Val Gln 
    1490                 1495                 1500             


Glu Phe  Glu His Ile Asn Gly  Arg Trp Ser Met Pro  Glu Leu Met 
    1505                 1510                 1515             


Pro Asp  Pro Ser Ala Asp Ser  Lys Arg Ser Ser Arg  Ala Ser Ser 
    1520                 1525                 1530             


Pro Thr  Lys Thr Ser Pro Thr  Thr Pro Glu Ala Ser  Ala Thr Asn 
    1535                 1540                 1545             


Ser Pro  Cys Thr Ser Lys Pro  Ala Thr Pro Ala Pro  Ser Glu Lys 
    1550                 1555                 1560             


Gly Glu  Gly Ile Arg Thr Pro  Leu Glu Lys Glu Glu  Ala Glu Asn 
    1565                 1570                 1575             


Gln Glu  Glu Lys Pro Glu Lys  Asn Ser Arg Ile Gly  Glu Lys Met 
    1580                 1585                 1590             


Glu Thr  Glu Ala Asp Ala Pro  Ser Pro Ala Pro Ser  Leu Gly Glu 
    1595                 1600                 1605             


Arg Leu  Glu Pro Arg Lys Ile  Pro Leu Glu Asp Glu  Val Pro Gly 
    1610                 1615                 1620             


Val Pro  Gly Glu Met Glu Pro  Glu Pro Gly Tyr Arg  Gly Asp Arg 
    1625                 1630                 1635             


Glu Lys  Ser Ala Thr Glu Ser  Thr Pro Gly Glu Arg  Gly Glu Glu 
    1640                 1645                 1650             


Lys Pro  Leu Asp Gly Gln Glu  His Arg Glu Arg Pro  Glu Gly Glu 
    1655                 1660                 1665             


Thr Gly  Asp Leu Gly Lys Arg  Glu Asp Val Lys Gly  Asp Arg Glu 
    1670                 1675                 1680             


Leu Arg  Pro Gly Pro Arg Asp  Glu Pro Arg Ser Asn  Gly Arg Arg 
    1685                 1690                 1695             


Glu Glu  Lys Thr Glu Lys Pro  Arg Phe Met Phe Asn  Ile Ala Asp 
    1700                 1705                 1710             


Gly Gly  Phe Thr Glu Leu His  Thr Leu Trp Gln Asn  Glu Glu Arg 
    1715                 1720                 1725             


Ala Ala  Ile Ser Ser Gly Lys  Leu Asn Glu Ile Trp  His Arg Arg 
    1730                 1735                 1740             


His Asp  Tyr Trp Leu Leu Ala  Gly Ile Val Leu His  Gly Tyr Ala 
    1745                 1750                 1755             


Arg Trp  Gln Asp Ile Gln Asn  Asp Ala Gln Phe Ala  Ile Ile Asn 
    1760                 1765                 1770             


Glu Pro  Phe Lys Thr Glu Ala  Asn Lys Gly Asn Phe  Leu Glu Met 
    1775                 1780                 1785             


Lys Asn  Lys Phe Leu Ala Arg  Arg Phe Lys Leu Leu  Glu Gln Ala 
    1790                 1795                 1800             


Leu Val  Ile Glu Glu Gln Leu  Arg Arg Ala Ala Tyr  Leu Asn Leu 
    1805                 1810                 1815             


Ser Gln  Glu Pro Ala His Pro  Ala Met Ala Leu His  Ala Arg Phe 
    1820                 1825                 1830             


Ala Glu  Ala Glu Cys Leu Ala  Glu Ser His Gln His  Leu Ser Lys 
    1835                 1840                 1845             


Glu Ser  Leu Ala Gly Asn Lys  Pro Ala Asn Ala Val  Leu His Lys 
    1850                 1855                 1860             


Val Leu  Asn Gln Leu Glu Glu  Leu Leu Ser Asp Met  Lys Ala Asp 
    1865                 1870                 1875             


Val Thr  Arg Leu Pro Ala Thr  Leu Ser Arg Ile Pro  Pro Ile Ala 
    1880                 1885                 1890             


Ala Arg  Leu Gln Met Ser Glu  Arg Ser Ile Leu Ser  Arg Leu Ala 
    1895                 1900                 1905             


Ser Lys  Gly Thr Glu Pro His  Pro Thr Pro Ala Tyr  Pro Pro Gly 
    1910                 1915                 1920             


Pro Tyr  Ala Thr Pro Pro Gly  Tyr Gly Ala Ala Phe  Ser Ala Ala 
    1925                 1930                 1935             


Pro Val  Gly Ala Leu Ala Ala  Ala Gly Ala Asn Tyr  Ser Gln Met 
    1940                 1945                 1950             


Pro Ala  Gly Ser Phe Ile Thr  Ala Ala Thr Asn Gly  Pro Pro Val 
    1955                 1960                 1965             


Leu Val  Lys Lys Glu Lys Glu  Met Val Gly Ala Leu  Val Ser Asp 
    1970                 1975                 1980             


Gly Leu  Asp Arg Lys Glu Pro  Arg Ala Gly Glu Val  Ile Cys Ile 
    1985                 1990                 1995             


Asp Asp  
    2000 


<210>  74
<211>  2218
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Glu Glu Asp Ile Ala Cys Val Lys Asp Leu Val Ser Lys Tyr Leu 
1               5                   10                  15      


Val Asp Asn Glu Arg Leu Ser Arg Gln Lys Leu Ala Phe Leu Val Gln 
            20                  25                  30          


Thr Glu Pro Arg Met Leu Leu Met Glu Gly Leu Lys Leu Leu Ser Leu 
        35                  40                  45              


Cys Ile Glu Val Asp Ser Cys Asn Ala Asn Gly Cys Glu His Asn Ser 
    50                  55                  60                  


Glu Asp Lys Ser Val Glu Arg Ile Leu His Asp His Gly Ile Leu Thr 
65                  70                  75                  80  


Pro Ser Leu Cys Leu Trp Tyr Pro Asp Gly Tyr Lys Leu Thr Gly Asn 
                85                  90                  95      


Val Leu Ile Leu Leu Glu Cys Phe Val Arg Ser Ser Pro Ala Asn Phe 
            100                 105                 110         


Glu Gln Lys Tyr Ile Glu Asp Phe Lys Lys Leu Glu Gln Leu Lys Glu 
        115                 120                 125             


Asp Leu Lys Ser Val Asp Ile Asn Leu Ile Pro Leu Ile Asp Gly Arg 
    130                 135                 140                 


Thr Ser Phe Tyr Asn Glu Gln Ile Pro Asp Trp Val Asn Asp Lys Leu 
145                 150                 155                 160 


Arg Asp Thr Leu Phe Ser Leu Leu Lys Tyr Ala Gln Glu Ser Asn Ser 
                165                 170                 175     


Leu Phe Glu Glu Ser Glu Tyr Ser Arg Leu Cys Glu Ser Leu Phe Met 
            180                 185                 190         


Thr Ser Gly Arg Leu Ser Gly Val Glu Ser Leu Asn Val Leu Met Asp 
        195                 200                 205             


Asn Arg Ser Asn His Tyr Glu Glu Val Ile Ala Ser Cys His Gln Gly 
    210                 215                 220                 


Ile Asn Asn Lys Leu Thr Ala His Glu Val Lys Leu Gln Ile Glu Glu 
225                 230                 235                 240 


Glu Tyr Gln Val Phe Arg Asn Arg Leu Arg Lys Gly Glu Ile Glu Gly 
                245                 250                 255     


Gln Phe Leu Lys Val Asp Lys Ser Gln Leu Leu Asn Glu Leu Asn Asn 
            260                 265                 270         


Leu Tyr Ala Asp Lys Val Val Ala Glu Asp Asn Ile Glu His Leu Ile 
        275                 280                 285             


Tyr Gln Phe Lys Arg Ala Ser Pro Ile Leu Arg Phe Leu Tyr Ala Asn 
    290                 295                 300                 


Val Asp Glu Gly Asn Glu Lys Arg Gly Asn Gln Thr Ile Gly Glu Cys 
305                 310                 315                 320 


Gln Val Gln Cys Trp Arg Ser Phe Leu Asn Lys Val Lys Ser Leu Arg 
                325                 330                 335     


Ile Leu Asn Thr Arg Arg Lys Leu Leu Leu Ile Phe Asp Ala Leu Ile 
            340                 345                 350         


Leu Leu Ala Ser Lys His Asp Leu Met Lys Gln Lys Cys Leu Lys Gly 
        355                 360                 365             


Trp Leu Gly Ser Cys Phe Leu Arg Val Lys Asp Arg Leu Val Ser Leu 
    370                 375                 380                 


Glu Ala Thr Lys Arg Asp Leu Glu Lys Trp Gly Glu Arg Gly Asn Arg 
385                 390                 395                 400 


Leu Arg Ser Arg Ile Thr Gln Ser Ser Gln Cys Leu Ser Lys Asn Gln 
                405                 410                 415     


Ile Leu Asn Ser Ile Phe Gln Lys Thr Ile Leu Lys Ala Thr Thr Ala 
            420                 425                 430         


Leu Lys Asp Val Gly Ile Ser Val Asp His Tyr Lys Ile Asp Met Glu 
        435                 440                 445             


Val Ile Cys Leu Asn Ser Tyr Asp Leu Ile Met Asp Phe Asp Val Ser 
    450                 455                 460                 


Gly Val Val Pro Thr Ile Ser Tyr Gln Arg Thr Glu Glu Glu Thr Phe 
465                 470                 475                 480 


Pro Tyr Val Met Gly Asp Val Glu Leu Leu Gly Thr Thr Asp Leu Glu 
                485                 490                 495     


Arg Leu Ser Ser Leu Ser Leu Ala Leu Val Asn Ser Met Lys Thr Ser 
            500                 505                 510         


Ser Thr Val Lys Leu Arg Gln Asn Glu Phe Gly Pro Ala Arg Tyr Gln 
        515                 520                 525             


Val Val Arg Cys Lys Glu Ala Tyr Cys Gln Glu Phe Ser Leu Gly Asn 
    530                 535                 540                 


Thr Glu Leu Gln Leu Ile Tyr Gln Lys Thr Gly Glu Cys Ser Lys Cys 
545                 550                 555                 560 


Tyr Ala Ile Asn Asp Asn Lys Val Gly Glu Val Cys Ser Phe Tyr Ala 
                565                 570                 575     


Asp Pro Lys Arg Tyr Phe Pro Ala Ile Phe Ser Ala Glu Val Leu Gln 
            580                 585                 590         


Thr Thr Ile Ser Thr Met Ile Ser Trp Ile Glu Asp Cys Asn Glu Leu 
        595                 600                 605             


Glu Gly Gln Leu Asn Asn Ile Arg Ser Leu Thr Lys Met Ile Leu Val 
    610                 615                 620                 


Leu Ile Leu Ala His Pro Ser Lys Arg Ser Gln Lys Leu Leu Gln Asn 
625                 630                 635                 640 


Leu Arg Tyr Phe Val Met Ala Tyr Leu Ser Asp Tyr His His Lys Asp 
                645                 650                 655     


Leu Ile Asp Lys Ile Arg Glu Glu Leu Ile Thr Asp Val Glu Phe Leu 
            660                 665                 670         


Leu Tyr Arg Leu Ile Arg Thr Leu Met Asn Leu Val Leu Ser Glu Asp 
        675                 680                 685             


Val Lys Ser Met Met Thr Asn Arg Phe Lys Phe Ile Leu Asn Val Ser 
    690                 695                 700                 


Tyr Met Cys His Phe Ile Thr Lys Glu Thr Pro Asp Arg Leu Thr Asp 
705                 710                 715                 720 


Gln Ile Lys Cys Phe Glu Lys Phe Leu Glu Pro Lys Val Arg Phe Gly 
                725                 730                 735     


His Val Ser Thr Asn Pro Ala Asp Thr Ala Thr Glu Glu Glu Leu Asp 
            740                 745                 750         


Asp Met Val Tyr Asn Ala Lys Lys Phe Leu Ser Lys Asp Gly Cys Thr 
        755                 760                 765             


Thr Ile Glu Gly Pro Asp Tyr Lys Arg Pro Gly Val Ser Lys Lys Tyr 
    770                 775                 780                 


Leu Ser Leu Leu Thr Ser Ser Phe Asn Asn Gly Ser Leu Phe Lys Glu 
785                 790                 795                 800 


Arg Glu Val Lys Arg Glu Ile Lys Asp Pro Leu Ile Thr Ser Gly Ser 
                805                 810                 815     


Ala Ala Leu Asp Leu Ala Ser Lys Lys Ser Val Val Val Asn Lys Tyr 
            820                 825                 830         


Thr Asp Gly Ser Arg Ile Leu Asn Tyr Asp Phe Asn Lys Leu Thr Ala 
        835                 840                 845             


Leu Ala Val Ser Gln Leu Thr Glu Val Phe Ser Arg Lys Gly Lys Tyr 
    850                 855                 860                 


Leu Leu Asn Lys Gln Asp Tyr Glu Tyr Lys Val Gln Gln Ala Met Ser 
865                 870                 875                 880 


Asn Leu Val Leu Gly Ser Gly Gln Leu Lys Ser Asp Ala Asp Gly Ala 
                885                 890                 895     


Asp Leu Asp Glu Ile Leu Leu Asp Gly Gly Ala Ser Asp Tyr Phe Asp 
            900                 905                 910         


Gln Leu Lys Glu Thr Val Glu Lys Ile Val Asp Gln Tyr Arg Glu Pro 
        915                 920                 925             


Val Lys Leu Gly Ser Gly Pro Asn Gly Asp Gly Gln Pro Ser Ile Asn 
    930                 935                 940                 


Asp Leu Asp Glu Ile Val Ser Asn Lys Phe Tyr Ile Arg Leu Ile Lys 
945                 950                 955                 960 


Gly Glu Leu Ser Asn His Met Val Glu Glu Phe Asp His Asp Ile Leu 
                965                 970                 975     


Pro Gly Lys Phe Tyr Glu Glu Phe Cys Asn Ala Val Tyr Glu Asn Ser 
            980                 985                 990         


Arg Leu Lys Gln Lys Tyr Phe Tyr  Cys Gly His Met Ser  Gln Cys Pro 
        995                 1000                 1005             


Ile Gly  Glu Leu Thr Lys Ala  Val Ser Thr Arg Thr  Tyr Phe Asn 
    1010                 1015                 1020             


His Glu  Tyr Phe Gln Cys Phe  Lys Ser Ile Leu Leu  Ile Met Asn 
    1025                 1030                 1035             


Ala Asn  Thr Leu Met Gly Arg  Tyr Thr His Tyr Lys  Ser Arg Asn 
    1040                 1045                 1050             


Leu Asn  Phe Lys Phe Asp Met  Gly Lys Leu Ser Asp  Asp Val Arg 
    1055                 1060                 1065             


Ile Ser  Glu Arg Glu Ser Asn  Ser Glu Ala Leu Ser  Lys Ala Leu 
    1070                 1075                 1080             


Ser Leu  Thr Asn Cys Thr Thr  Ala Met Leu Lys Asn  Leu Cys Phe 
    1085                 1090                 1095             


Tyr Ser  Gln Glu Ser Pro Gln  Ser Tyr Asp Ser Val  Gly Pro Asp 
    1100                 1105                 1110             


Thr Gly  Arg Leu Lys Phe Ser  Leu Ser Tyr Lys Glu  Gln Val Gly 
    1115                 1120                 1125             


Gly Asn  Arg Glu Leu Tyr Ile  Gly Asp Leu Arg Thr  Lys Met Phe 
    1130                 1135                 1140             


Thr Arg  Leu Ile Glu Asp Tyr  Phe Glu Ala Ile Ser  Leu Gln Leu 
    1145                 1150                 1155             


Ser Gly  Ser Cys Leu Asn Asn  Glu Lys Glu Phe Glu  Asn Ala Ile 
    1160                 1165                 1170             


Leu Ser  Met Lys Leu Asn Val  Ser Leu Ala His Val  Ser Tyr Ser 
    1175                 1180                 1185             


Met Asp  His Ser Lys Trp Gly  Pro Met Met Cys Pro  Phe Leu Phe 
    1190                 1195                 1200             


Leu Thr  Val Leu Gln Asn Leu  Ile Phe Leu Ser Lys  Asp Leu Gln 
    1205                 1210                 1215             


Ala Asp  Ile Lys Gly Arg Asp  Tyr Leu Ser Thr Leu  Leu Met Trp 
    1220                 1225                 1230             


His Met  His Lys Met Val Glu  Ile Pro Phe Asn Val  Val Thr Ala 
    1235                 1240                 1245             


Met Met  Lys Ser Phe Ile Lys  Ala Gln Leu Gly Leu  Arg Lys Lys 
    1250                 1255                 1260             


Thr Lys  Gln Ser Ile Thr Glu  Asp Phe Phe Tyr Ser  Asn Phe Gln 
    1265                 1270                 1275             


Ala Gly  Val Val Pro Ser His  Ile Ser Ser Ile Leu  Asp Met Gly 
    1280                 1285                 1290             


Gln Gly  Ile Leu His Asn Thr  Ser Asp Phe Tyr Ala  Leu Ile Ser 
    1295                 1300                 1305             


Glu Arg  Phe Ile Asn Tyr Ala  Ile Ser Cys Ile Cys  Gly Gly Thr 
    1310                 1315                 1320             


Ile Asp  Ala Tyr Thr Ser Ser  Asp Asp Gln Ile Ser  Leu Phe Asp 
    1325                 1330                 1335             


Gln Ser  Leu Thr Glu Leu Leu  Gln Arg Asp Pro Glu  Glu Phe Arg 
    1340                 1345                 1350             


Thr Leu  Ile Glu Phe His Tyr  Tyr Met Ser Asp Gln  Leu Asn Lys 
    1355                 1360                 1365             


Phe Val  Ser Pro Lys Ser Val  Ile Gly Arg Phe Val  Ala Glu Phe 
    1370                 1375                 1380             


Lys Ser  Arg Phe Phe Val Trp  Gly Asp Glu Val Pro  Leu Leu Thr 
    1385                 1390                 1395             


Lys Phe  Val Ala Ala Ala Leu  His Asn Ile Lys Cys  Lys Glu Pro 
    1400                 1405                 1410             


His Gln  Leu Ala Glu Thr Ile  Asp Thr Ile Ile Asp  Gln Ser Val 
    1415                 1420                 1425             


Ala Asn  Gly Val Pro Val His  Leu Cys Asn Leu Ile  Gln Lys Arg 
    1430                 1435                 1440             


Thr Leu  Asn Pro Leu Gln Tyr  Ala Arg Tyr Pro Ile  Asp Pro Phe 
    1445                 1450                 1455             


Leu Leu  Asn Cys Glu Thr Asp  Val Arg Asp Trp Val  Asp Gly Asn 
    1460                 1465                 1470             


Arg Ser  Tyr Arg Ile Met Arg  Gln Ile Glu Gly Leu  Ile Pro Asn 
    1475                 1480                 1485             


Ala Cys  Ser Lys Ile Arg Ser  Met Leu Arg Lys Leu  Tyr Asn Arg 
    1490                 1495                 1500             


Leu Lys  Thr Gly Gln Leu His  Glu Glu Phe Thr Thr  Asn Tyr Leu 
    1505                 1510                 1515             


Ser Ser  Glu His Leu Ser Ser  Leu Arg Asn Leu Cys  Glu Leu Leu 
    1520                 1525                 1530             


Asp Val  Glu Pro Pro Ser Glu  Ser Asp Leu Glu Tyr  Ser Trp Leu 
    1535                 1540                 1545             


Asn Leu  Ala Ala His His Pro  Leu Arg Met Val Leu  Arg Gln Lys 
    1550                 1555                 1560             


Ile Ile  Tyr Ser Gly Ala Val  Asn Leu Asp Asp Glu  Lys Ile Pro 
    1565                 1570                 1575             


Thr Ile  Val Lys Thr Ile Gln  Asn Lys Leu Ser Ser  Thr Phe Thr 
    1580                 1585                 1590             


Arg Gly  Ala Gln Lys Leu Leu  Ser Glu Ala Ile Asn  Lys Ser Ala 
    1595                 1600                 1605             


Phe Gln  Ser Ser Ile Ala Ser  Gly Phe Val Gly Leu  Cys Arg Thr 
    1610                 1615                 1620             


Leu Gly  Ser Lys Cys Val Arg  Gly Pro Asn Lys Glu  Asn Leu Tyr 
    1625                 1630                 1635             


Ile Lys  Ser Ile Gln Ser Leu  Ile Ser Asp Val Lys  Gly Ile Lys 
    1640                 1645                 1650             


Leu Leu  Thr Asn Ser Asn Gly  Ile Gln Tyr Trp Gln  Val Pro Leu 
    1655                 1660                 1665             


Glu Leu  Arg Asn Gly Ser Gly  Gly Glu Ser Val Val  Ser Tyr Phe 
    1670                 1675                 1680             


Arg Pro  Leu Leu Trp Asp Tyr  Met Cys Ile Ser Leu  Ser Thr Ala 
    1685                 1690                 1695             


Ile Glu  Leu Gly Ala Trp Val  Leu Gly Glu Pro Lys  Thr Val Lys 
    1700                 1705                 1710             


Val Phe  Asp Phe Phe Lys His  Asn Pro Cys Asp Tyr  Phe Pro Leu 
    1715                 1720                 1725             


Lys Pro  Thr Ala Ser Lys Leu  Leu Glu Asp Arg Val  Gly Leu Asn 
    1730                 1735                 1740             


His Ile  Ile His Ser Leu Arg  Arg Leu Tyr Pro Ser  Val Phe Glu 
    1745                 1750                 1755             


Lys His  Ile Leu Pro Phe Met  Ser Asp Leu Ala Ser  Thr Lys Met 
    1760                 1765                 1770             


Lys Trp  Ser Pro Arg Ile Lys  Phe Leu Asp Leu Cys  Val Ala Leu 
    1775                 1780                 1785             


Asp Val  Asn Cys Glu Ala Leu  Ser Leu Val Ser His  Ile Val Lys 
    1790                 1795                 1800             


Trp Lys  Arg Glu Glu His Tyr  Ile Val Leu Ser Ser  Glu Leu Arg 
    1805                 1810                 1815             


Leu Ser  His Ser Arg Thr His  Glu Pro Met Val Glu  Glu Arg Val 
    1820                 1825                 1830             


Val Ser  Thr Ser Asp Ala Val  Asp Asn Phe Met Arg  Gln Ile Tyr 
    1835                 1840                 1845             


Phe Glu  Ser Tyr Val Arg Pro  Phe Val Ala Thr Thr  Arg Thr Leu 
    1850                 1855                 1860             


Gly Ser  Phe Thr Trp Phe Pro  His Lys Thr Ser Val  Pro Glu Gly 
    1865                 1870                 1875             


Glu Gly  Leu His Arg Met Gly  Pro Phe Ser Ser Phe  Val Glu Lys 
    1880                 1885                 1890             


Val Ile  His Lys Gly Val Glu  Arg Pro Met Phe Lys  His Asp Leu 
    1895                 1900                 1905             


Met Met  Gly Tyr Ala Trp Ile  Asp Phe Asp Ile Glu  Pro Ala Arg 
    1910                 1915                 1920             


Phe Asn  Gln Asn Gln Leu Ile  Ala Ser Gly Leu Val  Asp Pro Lys 
    1925                 1930                 1935             


Phe Asp  Ser Leu Glu Asp Phe  Phe Asp Ala Val Ala  Ser Leu Pro 
    1940                 1945                 1950             


Pro Gly  Ser Ala Lys Leu Ser  Gln Thr Val Arg Phe  Arg Val Lys 
    1955                 1960                 1965             


Ser Gln  Asp Ala Ser Phe Lys  Glu Ser Phe Ala Ile  His Leu Glu 
    1970                 1975                 1980             


Tyr Thr  Gly Ser Met Asn Gln  Gln Ala Lys Tyr Leu  Val His Asp 
    1985                 1990                 1995             


Val Thr  Val Met Tyr Ser Gly  Ala Val Ser Pro Cys  Val Leu Ser 
    2000                 2005                 2010             


Asp Cys  Trp Arg Leu Val Leu  Ser Gly Pro Thr Phe  Lys Gly Lys 
    2015                 2020                 2025             


Ser Ala  Trp Tyr Val Asp Thr  Glu Ile Ile Asn Glu  Phe Leu Ile 
    2030                 2035                 2040             


Asp Thr  Asn Gln Leu Gly His  Val Thr Pro Val Glu  Ile Val Val 
    2045                 2050                 2055             


Asp Met  Glu Arg Leu Gln Phe  Thr Glu Tyr Asp Phe  Val Leu Val 
    2060                 2065                 2070             


Gly Pro  Cys Thr Glu Pro Thr  Pro Leu Val Val His  Arg Gly Gly 
    2075                 2080                 2085             


Leu Trp  Glu Cys Gly Lys Lys  Leu Ala Ser Phe Thr  Pro Val Ile 
    2090                 2095                 2100             


Gln Asp  Gln Asp Leu Glu Ile  Phe Val Arg Glu Val  Gly Asp Thr 
    2105                 2110                 2115             


Ser Ser  Asp Leu Leu Ile Gly  Ala Leu Ser Asp Met  Met Ile Asp 
    2120                 2125                 2130             


Arg Leu  Gly Leu Arg Met Gln  Trp Ser Gly Val Asp  Ile Val Ser 
    2135                 2140                 2145             


Thr Leu  Arg Ala Ala Ala Pro  Ser Cys Glu Gly Ile  Leu Ser Ala 
    2150                 2155                 2160             


Val Leu  Glu Ala Val Asp Asn  Trp Val Glu Phe Lys  Gly Tyr Ala 
    2165                 2170                 2175             


Leu Cys  Tyr Ser Lys Ser Arg  Gly Lys Val Met Val  Gln Ser Ser 
    2180                 2185                 2190             


Gly Gly  Lys Leu Arg Leu Lys  Gly Arg Thr Cys Glu  Glu Leu Thr 
    2195                 2200                 2205             


Arg Lys  Asp Glu Cys Ile Glu  Asp Ile Glu 
    2210                 2215             


<210>  75
<211>  485
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Ala Leu Pro Pro Phe Phe Gly Gln Gly Arg Pro Gly Pro Pro Pro 
1               5                   10                  15      


Pro Gln Pro Pro Pro Pro Ala Pro Phe Gly Cys Pro Pro Pro Pro Leu 
            20                  25                  30          


Pro Ser Pro Ala Phe Pro Pro Pro Leu Pro Gln Arg Pro Gly Pro Phe 
        35                  40                  45              


Pro Gly Ala Ser Ala Pro Phe Leu Gln Pro Pro Leu Ala Leu Gln Pro 
    50                  55                  60                  


Arg Ala Ser Ala Glu Ala Ser Arg Gly Gly Gly Gly Ala Gly Ala Phe 
65                  70                  75                  80  


Tyr Pro Val Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro Gln Cys Arg 
                85                  90                  95      


Pro Phe Pro Gly Thr Asp Ala Gly Glu Arg Pro Arg Pro Pro Pro Pro 
            100                 105                 110         


Gly Pro Gly Pro Pro Trp Ser Pro Arg Trp Pro Glu Ala Pro Pro Pro 
        115                 120                 125             


Pro Ala Asp Val Leu Gly Asp Ala Ala Leu Gln Arg Leu Arg Asp Arg 
    130                 135                 140                 


Gln Trp Leu Glu Ala Val Phe Gly Thr Pro Arg Arg Ala Gly Cys Pro 
145                 150                 155                 160 


Val Pro Gln Arg Thr His Ala Gly Pro Ser Leu Gly Glu Val Arg Ala 
                165                 170                 175     


Arg Leu Leu Arg Ala Leu Arg Leu Val Arg Arg Leu Arg Gly Leu Ser 
            180                 185                 190         


Gln Ala Leu Arg Glu Ala Glu Ala Asp Gly Ala Ala Trp Val Leu Leu 
        195                 200                 205             


Tyr Ser Gln Thr Ala Pro Leu Arg Ala Glu Leu Ala Glu Arg Leu Gln 
    210                 215                 220                 


Pro Leu Thr Gln Ala Ala Tyr Val Gly Glu Ala Arg Arg Arg Leu Glu 
225                 230                 235                 240 


Arg Val Arg Arg Arg Arg Leu Arg Leu Arg Glu Arg Ala Arg Glu Arg 
                245                 250                 255     


Glu Ala Glu Arg Glu Ala Glu Ala Ala Arg Ala Val Glu Arg Glu Gln 
            260                 265                 270         


Glu Ile Asp Arg Trp Arg Val Lys Cys Val Gln Glu Val Glu Glu Lys 
        275                 280                 285             


Lys Arg Glu Gln Glu Leu Lys Ala Ala Ala Asp Gly Val Leu Ser Glu 
    290                 295                 300                 


Val Arg Lys Lys Gln Ala Asp Thr Lys Arg Met Val Asp Ile Leu Arg 
305                 310                 315                 320 


Ala Leu Glu Lys Leu Arg Lys Leu Arg Lys Glu Ala Ala Ala Arg Lys 
                325                 330                 335     


Gly Val Cys Pro Pro Ala Ser Ala Asp Glu Thr Phe Thr His His Leu 
            340                 345                 350         


Gln Arg Leu Arg Lys Leu Ile Lys Lys Arg Ser Glu Leu Tyr Glu Ala 
        355                 360                 365             


Glu Glu Arg Ala Leu Arg Val Met Leu Glu Gly Glu Gln Glu Glu Glu 
    370                 375                 380                 


Arg Lys Arg Glu Leu Glu Lys Lys Gln Arg Lys Glu Lys Glu Lys Ile 
385                 390                 395                 400 


Leu Leu Gln Lys Arg Glu Ile Glu Ser Lys Leu Phe Gly Asp Pro Asp 
                405                 410                 415     


Glu Phe Pro Leu Ala His Leu Leu Glu Pro Phe Arg Gln Tyr Tyr Leu 
            420                 425                 430         


Gln Ala Glu His Ser Leu Pro Ala Leu Ile Gln Ile Arg His Asp Trp 
        435                 440                 445             


Asp Gln Tyr Leu Val Pro Ser Asp His Pro Lys Gly Asn Phe Val Pro 
    450                 455                 460                 


Gln Gly Trp Val Leu Pro Pro Leu Pro Ser Asn Asp Ile Trp Ala Thr 
465                 470                 475                 480 


Ala Val Lys Leu His 
                485 


<210>  76
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Ala Glu Val Pro Glu Leu Ala Ser Glu Met Met Ala Tyr Tyr Ser 
1               5                   10                  15      


Gly Asn Glu Asp Asp Leu Phe Phe Glu Ala Asp Gly Pro Lys Gln Met 
            20                  25                  30          


Lys Cys Ser Phe Gln Asp Leu Asp Leu Cys Pro Leu Asp Gly Gly Ile 
        35                  40                  45              


Gln Leu Arg Ile Ser Asp His His Tyr Ser Lys Gly Phe Arg Gln Ala 
    50                  55                  60                  


Ala Ser Val Val Val Ala Met Asp Lys Leu Arg Lys Met Leu Val Pro 
65                  70                  75                  80  


Cys Pro Gln Thr Phe Gln Glu Asn Asp Leu Ser Thr Phe Phe Pro Phe 
                85                  90                  95      


Ile Phe Glu Glu Glu Pro Ile Phe Phe Asp Thr Trp Asp Asn Glu Ala 
            100                 105                 110         


Tyr Val His Asp Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp 
        115                 120                 125             


Ser Gln Gln Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala 
    130                 135                 140                 


Leu His Leu Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met 
145                 150                 155                 160 


Ser Phe Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu 
                165                 170                 175     


Gly Leu Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp 
            180                 185                 190         


Lys Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys 
        195                 200                 205             


Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn 
    210                 215                 220                 


Lys Leu Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr 
225                 230                 235                 240 


Ser Gln Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly 
                245                 250                 255     


Gln Asp Ile Thr Asp Phe Thr Met Gln Phe Val Ser Ser 
            260                 265                 


<210>  77
<211>  591
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Ser Glu Gln Ser Ile Cys Gln Ala Arg Ala Ala Val Met Val Tyr 
1               5                   10                  15      


Asp Asp Ala Asn Lys Lys Trp Val Pro Ala Gly Gly Ser Thr Gly Phe 
            20                  25                  30          


Ser Arg Val His Ile Tyr His His Thr Gly Asn Asn Thr Phe Arg Val 
        35                  40                  45              


Val Gly Arg Lys Ile Gln Asp His Gln Val Val Ile Asn Cys Ala Ile 
    50                  55                  60                  


Pro Lys Gly Leu Lys Tyr Asn Gln Ala Thr Gln Thr Phe His Gln Trp 
65                  70                  75                  80  


Arg Asp Ala Arg Gln Val Tyr Gly Leu Asn Phe Gly Ser Lys Glu Asp 
                85                  90                  95      


Ala Asn Val Phe Ala Ser Ala Met Met His Ala Leu Glu Val Leu Asn 
            100                 105                 110         


Ser Gln Glu Thr Gly Pro Thr Leu Pro Arg Gln Asn Ser Gln Leu Pro 
        115                 120                 125             


Ala Gln Val Gln Asn Gly Pro Ser Gln Glu Glu Leu Glu Ile Gln Arg 
    130                 135                 140                 


Arg Gln Leu Gln Glu Gln Gln Arg Gln Lys Glu Leu Glu Arg Glu Arg 
145                 150                 155                 160 


Leu Glu Arg Glu Arg Met Glu Arg Glu Arg Leu Glu Arg Glu Arg Leu 
                165                 170                 175     


Glu Arg Glu Arg Leu Glu Arg Glu Arg Leu Glu Gln Glu Gln Leu Glu 
            180                 185                 190         


Arg Glu Arg Gln Glu Arg Glu Arg Gln Glu Arg Leu Glu Arg Gln Glu 
        195                 200                 205             


Arg Leu Glu Arg Gln Glu Arg Leu Glu Arg Gln Glu Arg Leu Asp Arg 
    210                 215                 220                 


Glu Arg Gln Glu Arg Gln Glu Arg Glu Arg Leu Glu Arg Leu Glu Arg 
225                 230                 235                 240 


Glu Arg Gln Glu Arg Glu Arg Gln Glu Gln Leu Glu Arg Glu Gln Leu 
                245                 250                 255     


Glu Trp Glu Arg Glu Arg Arg Ile Ser Ser Ala Ala Ala Pro Ala Ser 
            260                 265                 270         


Val Glu Thr Pro Leu Asn Ser Val Leu Gly Asp Ser Ser Ala Ser Glu 
        275                 280                 285             


Pro Gly Leu Gln Ala Ala Ser Gln Pro Ala Glu Thr Pro Ser Gln Gln 
    290                 295                 300                 


Gly Ile Val Leu Gly Pro Leu Ala Pro Pro Pro Pro Pro Pro Leu Pro 
305                 310                 315                 320 


Pro Gly Pro Ala Gln Ala Ser Val Ala Leu Pro Pro Pro Pro Gly Pro 
                325                 330                 335     


Pro Pro Pro Pro Pro Leu Pro Ser Thr Gly Pro Pro Pro Pro Pro Pro 
            340                 345                 350         


Pro Pro Pro Leu Pro Asn Gln Val Pro Pro Pro Pro Pro Pro Pro Pro 
        355                 360                 365             


Ala Pro Pro Leu Pro Ala Ser Gly Phe Phe Leu Ala Ser Met Ser Glu 
    370                 375                 380                 


Asp Asn Arg Pro Leu Thr Gly Leu Ala Ala Ala Ile Ala Gly Ala Lys 
385                 390                 395                 400 


Leu Arg Lys Val Ser Arg Met Glu Asp Thr Ser Phe Pro Ser Gly Gly 
                405                 410                 415     


Asn Ala Ile Gly Val Asn Ser Ala Ser Ser Lys Thr Asp Thr Gly Arg 
            420                 425                 430         


Gly Asn Gly Pro Leu Pro Leu Gly Gly Ser Gly Leu Met Glu Glu Met 
        435                 440                 445             


Ser Ala Leu Leu Ala Arg Arg Arg Arg Ile Ala Glu Lys Gly Ser Thr 
    450                 455                 460                 


Ile Glu Thr Glu Gln Lys Glu Asp Lys Gly Glu Asp Ser Glu Pro Val 
465                 470                 475                 480 


Thr Ser Lys Ala Ser Ser Thr Ser Thr Pro Glu Pro Thr Arg Lys Pro 
                485                 490                 495     


Trp Glu Arg Thr Asn Thr Met Asn Gly Ser Lys Ser Pro Val Ile Ser 
            500                 505                 510         


Arg Arg Asp Ser Pro Arg Lys Asn Gln Ile Val Phe Asp Asn Arg Ser 
        515                 520                 525             


Tyr Asp Ser Leu His Arg Pro Lys Ser Thr Pro Leu Ser Gln Pro Ser 
    530                 535                 540                 


Ala Asn Gly Val Gln Thr Glu Gly Leu Asp Tyr Asp Arg Leu Lys Gln 
545                 550                 555                 560 


Asp Ile Leu Asp Glu Met Arg Lys Glu Leu Thr Lys Leu Lys Glu Glu 
                565                 570                 575     


Leu Ile Asp Ala Ile Arg Gln Glu Leu Ser Lys Ser Asn Thr Ala 
            580                 585                 590     


<210>  78
<211>  603
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Ala Ser Ala Ser Thr Ser Lys Tyr Asn Ser His Ser Leu Glu Asn 
1               5                   10                  15      


Glu Ser Ile Lys Arg Thr Ser Arg Asp Gly Val Asn Arg Asp Leu Thr 
            20                  25                  30          


Glu Ala Val Pro Arg Leu Pro Gly Glu Thr Leu Ile Thr Asp Lys Glu 
        35                  40                  45              


Val Ile Tyr Ile Cys Pro Phe Asn Gly Pro Ile Lys Gly Arg Val Tyr 
    50                  55                  60                  


Ile Thr Asn Tyr Arg Leu Tyr Leu Arg Ser Leu Glu Thr Asp Ser Ser 
65                  70                  75                  80  


Leu Ile Leu Asp Val Pro Leu Gly Val Ile Ser Arg Ile Glu Lys Met 
                85                  90                  95      


Gly Gly Ala Thr Ser Arg Gly Glu Asn Ser Tyr Gly Leu Asp Ile Thr 
            100                 105                 110         


Cys Lys Asp Met Arg Asn Leu Arg Phe Ala Leu Lys Gln Glu Gly His 
        115                 120                 125             


Ser Arg Arg Asp Met Phe Glu Ile Leu Thr Arg Tyr Ala Phe Pro Leu 
    130                 135                 140                 


Ala His Ser Leu Pro Leu Phe Ala Phe Leu Asn Glu Glu Lys Phe Asn 
145                 150                 155                 160 


Val Asp Gly Trp Thr Val Tyr Asn Pro Val Glu Glu Tyr Arg Arg Gln 
                165                 170                 175     


Gly Leu Pro Asn His His Trp Arg Ile Thr Phe Ile Asn Lys Cys Tyr 
            180                 185                 190         


Glu Leu Cys Asp Thr Tyr Pro Ala Leu Leu Val Val Pro Tyr Arg Ala 
        195                 200                 205             


Ser Asp Asp Asp Leu Arg Arg Val Ala Thr Phe Arg Ser Arg Asn Arg 
    210                 215                 220                 


Ile Pro Val Leu Ser Trp Ile His Pro Glu Asn Lys Thr Val Ile Val 
225                 230                 235                 240 


Arg Cys Ser Gln Pro Leu Val Gly Met Ser Gly Lys Arg Asn Lys Asp 
                245                 250                 255     


Asp Glu Lys Tyr Leu Asp Val Ile Arg Glu Thr Asn Lys Gln Ile Ser 
            260                 265                 270         


Lys Leu Thr Ile Tyr Asp Ala Arg Pro Ser Val Asn Ala Val Ala Asn 
        275                 280                 285             


Lys Ala Thr Gly Gly Gly Tyr Glu Ser Asp Asp Ala Tyr His Asn Ala 
    290                 295                 300                 


Glu Leu Phe Phe Leu Asp Ile His Asn Ile His Val Met Arg Glu Ser 
305                 310                 315                 320 


Leu Lys Lys Val Lys Asp Ile Val Tyr Pro Asn Val Glu Glu Ser His 
                325                 330                 335     


Trp Leu Ser Ser Leu Glu Ser Thr His Trp Leu Glu His Ile Lys Leu 
            340                 345                 350         


Val Leu Thr Gly Ala Ile Gln Val Ala Asp Lys Val Ser Ser Gly Lys 
        355                 360                 365             


Ser Ser Val Leu Val His Cys Ser Asp Gly Trp Asp Arg Thr Ala Gln 
    370                 375                 380                 


Leu Thr Ser Leu Ala Met Leu Met Leu Asp Ser Phe Tyr Arg Ser Ile 
385                 390                 395                 400 


Glu Gly Phe Glu Ile Leu Val Gln Lys Glu Trp Ile Ser Phe Gly His 
                405                 410                 415     


Lys Phe Ala Ser Arg Ile Gly His Gly Asp Lys Asn His Thr Asp Ala 
            420                 425                 430         


Asp Arg Ser Pro Ile Phe Leu Gln Phe Ile Asp Cys Val Trp Gln Met 
        435                 440                 445             


Ser Lys Gln Phe Pro Thr Ala Phe Glu Phe Asn Glu Gln Phe Leu Ile 
    450                 455                 460                 


Ile Ile Leu Asp His Leu Tyr Ser Cys Arg Phe Gly Thr Phe Leu Phe 
465                 470                 475                 480 


Asn Cys Glu Ser Ala Arg Glu Arg Gln Lys Val Thr Glu Arg Thr Val 
                485                 490                 495     


Ser Leu Trp Ser Leu Ile Asn Ser Asn Lys Glu Lys Phe Lys Asn Pro 
            500                 505                 510         


Phe Tyr Thr Lys Glu Ile Asn Arg Val Leu Tyr Pro Val Ala Ser Met 
        515                 520                 525             


Arg His Leu Glu Leu Trp Val Asn Tyr Tyr Ile Arg Trp Asn Pro Arg 
    530                 535                 540                 


Ile Lys Gln Gln Gln Pro Asn Pro Val Glu Gln Arg Tyr Met Glu Leu 
545                 550                 555                 560 


Leu Ala Leu Arg Asp Glu Tyr Ile Lys Arg Leu Glu Glu Leu Gln Leu 
                565                 570                 575     


Ala Asn Ser Ala Lys Leu Ser Asp Pro Pro Thr Ser Pro Ser Ser Pro 
            580                 585                 590         


Ser Gln Met Met Pro His Val Gln Thr His Phe 
        595                 600             


<210>  79
<211>  683
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Ala Ala Leu Leu Leu Leu Pro Leu Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Lys Leu His Leu Trp Pro Gln Leu Arg Trp Leu Pro Ala Asp 
            20                  25                  30          


Leu Ala Phe Ala Val Arg Ala Leu Cys Cys Lys Arg Ala Leu Arg Ala 
        35                  40                  45              


Arg Ala Leu Ala Ala Ala Ala Ala Asp Pro Glu Gly Pro Glu Gly Gly 
    50                  55                  60                  


Cys Ser Leu Ala Trp Arg Leu Ala Glu Leu Ala Gln Gln Arg Ala Ala 
65                  70                  75                  80  


His Thr Phe Leu Ile His Gly Ser Arg Arg Phe Ser Tyr Ser Glu Ala 
                85                  90                  95      


Glu Arg Glu Ser Asn Arg Ala Ala Arg Ala Phe Leu Arg Ala Leu Gly 
            100                 105                 110         


Trp Asp Trp Gly Pro Asp Gly Gly Asp Ser Gly Glu Gly Ser Ala Gly 
        115                 120                 125             


Glu Gly Glu Arg Ala Ala Pro Gly Ala Gly Asp Ala Ala Ala Gly Ser 
    130                 135                 140                 


Gly Ala Glu Phe Ala Gly Gly Asp Gly Ala Ala Arg Gly Gly Gly Ala 
145                 150                 155                 160 


Ala Ala Pro Leu Ser Pro Gly Ala Thr Val Ala Leu Leu Leu Pro Ala 
                165                 170                 175     


Gly Pro Glu Phe Leu Trp Leu Trp Phe Gly Leu Ala Lys Ala Gly Leu 
            180                 185                 190         


Arg Thr Ala Phe Val Pro Thr Ala Leu Arg Arg Gly Pro Leu Leu His 
        195                 200                 205             


Cys Leu Arg Ser Cys Gly Ala Arg Ala Leu Val Leu Ala Pro Glu Phe 
    210                 215                 220                 


Leu Glu Ser Leu Glu Pro Asp Leu Pro Ala Leu Arg Ala Met Gly Leu 
225                 230                 235                 240 


His Leu Trp Ala Ala Gly Pro Gly Thr His Pro Ala Gly Ile Ser Asp 
                245                 250                 255     


Leu Leu Ala Glu Val Ser Ala Glu Val Asp Gly Pro Val Pro Gly Tyr 
            260                 265                 270         


Leu Ser Ser Pro Gln Ser Ile Thr Asp Thr Cys Leu Tyr Ile Phe Thr 
        275                 280                 285             


Ser Gly Thr Thr Gly Leu Pro Lys Ala Ala Arg Ile Ser His Leu Lys 
    290                 295                 300                 


Ile Leu Gln Cys Gln Gly Phe Tyr Gln Leu Cys Gly Val His Gln Glu 
305                 310                 315                 320 


Asp Val Ile Tyr Leu Ala Leu Pro Leu Tyr His Met Ser Gly Ser Leu 
                325                 330                 335     


Leu Gly Ile Val Gly Cys Met Gly Ile Gly Ala Thr Val Val Leu Lys 
            340                 345                 350         


Ser Lys Phe Ser Ala Gly Gln Phe Trp Glu Asp Cys Gln Gln His Arg 
        355                 360                 365             


Val Thr Val Phe Gln Tyr Ile Gly Glu Leu Cys Arg Tyr Leu Val Asn 
    370                 375                 380                 


Gln Pro Pro Ser Lys Ala Glu Arg Gly His Lys Val Arg Leu Ala Val 
385                 390                 395                 400 


Gly Ser Gly Leu Arg Pro Asp Thr Trp Glu Arg Phe Val Arg Arg Phe 
                405                 410                 415     


Gly Pro Leu Gln Val Leu Glu Thr Tyr Gly Leu Thr Glu Gly Asn Val 
            420                 425                 430         


Ala Thr Ile Asn Tyr Thr Gly Gln Arg Gly Ala Val Gly Arg Ala Ser 
        435                 440                 445             


Trp Leu Tyr Lys His Ile Phe Pro Phe Ser Leu Ile Arg Tyr Asp Val 
    450                 455                 460                 


Thr Thr Gly Glu Pro Ile Arg Asp Pro Gln Gly His Cys Met Ala Thr 
465                 470                 475                 480 


Ser Pro Gly Glu Pro Gly Leu Leu Val Ala Pro Val Ser Gln Gln Ser 
                485                 490                 495     


Pro Phe Leu Gly Tyr Ala Gly Gly Pro Glu Leu Ala Gln Gly Lys Leu 
            500                 505                 510         


Leu Lys Asp Val Phe Arg Pro Gly Asp Val Phe Phe Asn Thr Gly Asp 
        515                 520                 525             


Leu Leu Val Cys Asp Asp Gln Gly Phe Leu Arg Phe His Asp Arg Thr 
    530                 535                 540                 


Gly Asp Thr Phe Arg Trp Lys Gly Glu Asn Val Ala Thr Thr Glu Val 
545                 550                 555                 560 


Ala Glu Val Phe Glu Ala Leu Asp Phe Leu Gln Glu Val Asn Val Tyr 
                565                 570                 575     


Gly Val Thr Val Pro Gly His Glu Gly Arg Ala Gly Met Ala Ala Leu 
            580                 585                 590         


Val Leu Arg Pro Pro His Ala Leu Asp Leu Met Gln Leu Tyr Thr His 
        595                 600                 605             


Val Ser Glu Asn Leu Pro Pro Tyr Ala Arg Pro Arg Phe Leu Arg Leu 
    610                 615                 620                 


Gln Glu Ser Leu Ala Thr Thr Glu Thr Phe Lys Gln Gln Lys Val Arg 
625                 630                 635                 640 


Met Ala Asn Glu Gly Phe Asp Pro Ser Thr Leu Ser Asp Pro Leu Tyr 
                645                 650                 655     


Val Leu Asp Gln Ala Val Gly Ala Tyr Leu Pro Leu Thr Thr Ala Arg 
            660                 665                 670         


Tyr Ser Ala Leu Leu Ala Gly Asn Leu Arg Ile 
        675                 680             


<210>  80
<211>  780
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Glu Gln Val Glu Ile Leu Arg Lys Phe Ile Gln Arg Val Gln Ala 
1               5                   10                  15      


Met Lys Ser Pro Asp His Asn Gly Glu Asp Asn Phe Ala Arg Asp Phe 
            20                  25                  30          


Met Arg Leu Arg Arg Leu Ser Thr Lys Tyr Arg Thr Glu Lys Ile Tyr 
        35                  40                  45              


Pro Thr Ala Thr Gly Glu Lys Glu Glu Asn Val Lys Lys Asn Arg Tyr 
    50                  55                  60                  


Lys Asp Ile Leu Pro Phe Asp His Ser Arg Val Lys Leu Thr Leu Lys 
65                  70                  75                  80  


Thr Pro Ser Gln Asp Ser Asp Tyr Ile Asn Ala Asn Phe Ile Lys Gly 
                85                  90                  95      


Val Tyr Gly Pro Lys Ala Tyr Val Ala Thr Gln Gly Pro Leu Ala Asn 
            100                 105                 110         


Thr Val Ile Asp Phe Trp Arg Met Ile Trp Glu Tyr Asn Val Val Ile 
        115                 120                 125             


Ile Val Met Ala Cys Arg Glu Phe Glu Met Gly Arg Lys Lys Cys Glu 
    130                 135                 140                 


Arg Tyr Trp Pro Leu Tyr Gly Glu Asp Pro Ile Thr Phe Ala Pro Phe 
145                 150                 155                 160 


Lys Ile Ser Cys Glu Asp Glu Gln Ala Arg Thr Asp Tyr Phe Ile Arg 
                165                 170                 175     


Thr Leu Leu Leu Glu Phe Gln Asn Glu Ser Arg Arg Leu Tyr Gln Phe 
            180                 185                 190         


His Tyr Val Asn Trp Pro Asp His Asp Val Pro Ser Ser Phe Asp Ser 
        195                 200                 205             


Ile Leu Asp Met Ile Ser Leu Met Arg Lys Tyr Gln Glu His Glu Asp 
    210                 215                 220                 


Val Pro Ile Cys Ile His Cys Ser Ala Gly Cys Gly Arg Thr Gly Ala 
225                 230                 235                 240 


Ile Cys Ala Ile Asp Tyr Thr Trp Asn Leu Leu Lys Ala Gly Lys Ile 
                245                 250                 255     


Pro Glu Glu Phe Asn Val Phe Asn Leu Ile Gln Glu Met Arg Thr Gln 
            260                 265                 270         


Arg His Ser Ala Val Gln Thr Lys Glu Gln Tyr Glu Leu Val His Arg 
        275                 280                 285             


Ala Ile Ala Gln Leu Phe Glu Lys Gln Leu Gln Leu Tyr Glu Ile His 
    290                 295                 300                 


Gly Ala Gln Lys Ile Ala Asp Gly Val Asn Glu Ile Asn Thr Glu Asn 
305                 310                 315                 320 


Met Val Ser Ser Ile Glu Pro Glu Lys Gln Asp Ser Pro Pro Pro Lys 
                325                 330                 335     


Pro Pro Arg Thr Arg Ser Cys Leu Val Glu Gly Asp Ala Lys Glu Glu 
            340                 345                 350         


Ile Leu Gln Pro Pro Glu Pro His Pro Val Pro Pro Ile Leu Thr Pro 
        355                 360                 365             


Ser Pro Pro Ser Ala Phe Pro Thr Val Thr Thr Val Trp Gln Asp Asn 
    370                 375                 380                 


Asp Arg Tyr His Pro Lys Pro Val Leu His Met Val Ser Ser Glu Gln 
385                 390                 395                 400 


His Ser Ala Asp Leu Asn Arg Asn Tyr Ser Lys Ser Thr Glu Leu Pro 
                405                 410                 415     


Gly Lys Asn Glu Ser Thr Ile Glu Gln Ile Asp Lys Lys Leu Glu Arg 
            420                 425                 430         


Asn Leu Ser Phe Glu Ile Lys Lys Val Pro Leu Gln Glu Gly Pro Lys 
        435                 440                 445             


Ser Phe Asp Gly Asn Thr Leu Leu Asn Arg Gly His Ala Ile Lys Ile 
    450                 455                 460                 


Lys Ser Ala Ser Pro Cys Ile Ala Asp Lys Ile Ser Lys Pro Gln Glu 
465                 470                 475                 480 


Leu Ser Ser Asp Leu Asn Val Gly Asp Thr Ser Gln Asn Ser Cys Val 
                485                 490                 495     


Asp Cys Ser Val Thr Gln Ser Asn Lys Val Ser Val Thr Pro Pro Glu 
            500                 505                 510         


Glu Ser Gln Asn Ser Asp Thr Pro Pro Arg Pro Asp Arg Leu Pro Leu 
        515                 520                 525             


Asp Glu Lys Gly His Val Thr Trp Ser Phe His Gly Pro Glu Asn Ala 
    530                 535                 540                 


Ile Pro Ile Pro Asp Leu Ser Glu Gly Asn Ser Ser Asp Ile Asn Tyr 
545                 550                 555                 560 


Gln Thr Arg Lys Thr Val Ser Leu Thr Pro Ser Pro Thr Thr Gln Val 
                565                 570                 575     


Glu Thr Pro Asp Leu Val Asp His Asp Asn Thr Ser Pro Leu Phe Arg 
            580                 585                 590         


Thr Pro Leu Ser Phe Thr Asn Pro Leu His Ser Asp Asp Ser Asp Ser 
        595                 600                 605             


Asp Glu Arg Asn Ser Asp Gly Ala Val Thr Gln Asn Lys Thr Asn Ile 
    610                 615                 620                 


Ser Thr Ala Ser Ala Thr Val Ser Ala Ala Thr Ser Thr Glu Ser Ile 
625                 630                 635                 640 


Ser Thr Arg Lys Val Leu Pro Met Ser Ile Ala Arg His Asn Ile Ala 
                645                 650                 655     


Gly Thr Thr His Ser Gly Ala Glu Lys Asp Val Asp Val Ser Glu Asp 
            660                 665                 670         


Ser Pro Pro Pro Leu Pro Glu Arg Thr Pro Glu Ser Phe Val Leu Ala 
        675                 680                 685             


Ser Glu His Asn Thr Pro Val Arg Ser Glu Trp Ser Glu Leu Gln Ser 
    690                 695                 700                 


Gln Glu Arg Ser Glu Gln Lys Lys Ser Glu Gly Leu Ile Thr Ser Glu 
705                 710                 715                 720 


Asn Glu Lys Cys Asp His Pro Ala Gly Gly Ile His Tyr Glu Met Cys 
                725                 730                 735     


Ile Glu Cys Pro Pro Thr Phe Ser Asp Lys Arg Glu Gln Ile Ser Glu 
            740                 745                 750         


Asn Pro Thr Glu Ala Thr Asp Ile Gly Phe Gly Asn Arg Cys Gly Lys 
        755                 760                 765             


Pro Lys Gly Pro Arg Asp Pro Pro Ser Glu Trp Thr 
    770                 775                 780 


<210>  81
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Gly Pro Gly Gly Pro Leu Leu Ser Pro Ser Arg Gly Phe Leu Leu 
1               5                   10                  15      


Cys Lys Thr Gly Trp His Ser Asn Arg Leu Leu Gly Asp Cys Gly Pro 
            20                  25                  30          


His Thr Pro Val Ser Thr Ala Leu Ser Phe Ile Ala Val Gly Met Ala 
        35                  40                  45              


Ala Pro Ser Met Lys Glu Arg Gln Val Cys Trp Gly Ala Arg Asp Glu 
    50                  55                  60                  


Tyr Trp Lys Cys Leu Asp Glu Asn Leu Glu Asp Ala Ser Gln Cys Lys 
65                  70                  75                  80  


Lys Leu Arg Ser Ser Phe Glu Ser Ser Cys Pro Gln Gln Trp Ile Lys 
                85                  90                  95      


Tyr Phe Asp Lys Arg Arg Asp Tyr Leu Lys Phe Lys Glu Lys Phe Glu 
            100                 105                 110         


Ala Gly Gln Phe Glu Pro Ser Glu Thr Thr Ala Lys Ser 
        115                 120                 125 


<210>  82
<211>  698
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Arg Arg Phe Leu Leu Leu Tyr Ala Thr Gln Gln Gly Gln Ala Lys 
1               5                   10                  15      


Ala Ile Ala Glu Glu Ile Cys Glu Gln Ala Val Val His Gly Phe Ser 
            20                  25                  30          


Ala Asp Leu His Cys Ile Ser Glu Ser Asp Lys Tyr Asp Leu Lys Thr 
        35                  40                  45              


Glu Thr Ala Pro Leu Val Val Val Val Ser Thr Thr Gly Thr Gly Asp 
    50                  55                  60                  


Pro Pro Asp Thr Ala Arg Lys Phe Val Lys Glu Ile Gln Asn Gln Thr 
65                  70                  75                  80  


Leu Pro Val Asp Phe Phe Ala His Leu Arg Tyr Gly Leu Leu Gly Leu 
                85                  90                  95      


Gly Asp Ser Glu Tyr Thr Tyr Phe Cys Asn Gly Gly Lys Ile Ile Asp 
            100                 105                 110         


Lys Arg Leu Gln Glu Leu Gly Ala Arg His Phe Tyr Asp Thr Gly His 
        115                 120                 125             


Ala Asp Asp Cys Val Gly Leu Glu Leu Val Val Glu Pro Trp Ile Ala 
    130                 135                 140                 


Gly Leu Trp Pro Ala Leu Arg Lys His Phe Arg Ser Ser Arg Gly Gln 
145                 150                 155                 160 


Glu Glu Ile Ser Gly Ala Leu Pro Val Ala Ser Pro Ala Ser Ser Arg 
                165                 170                 175     


Thr Asp Leu Val Lys Ser Glu Leu Leu His Ile Glu Ser Gln Val Glu 
            180                 185                 190         


Leu Leu Arg Phe Asp Asp Ser Gly Arg Lys Asp Ser Glu Val Leu Lys 
        195                 200                 205             


Gln Asn Ala Val Asn Ser Asn Gln Ser Asn Val Val Ile Glu Asp Phe 
    210                 215                 220                 


Glu Ser Ser Leu Thr Arg Ser Val Pro Pro Leu Ser Gln Ala Ser Leu 
225                 230                 235                 240 


Asn Ile Pro Gly Leu Pro Pro Glu Tyr Leu Gln Val His Leu Gln Glu 
                245                 250                 255     


Ser Leu Gly Gln Glu Glu Ser Gln Val Ser Val Thr Ser Ala Asp Pro 
            260                 265                 270         


Val Phe Gln Val Pro Ile Ser Lys Ala Val Gln Leu Thr Thr Asn Asp 
        275                 280                 285             


Ala Ile Lys Thr Thr Leu Leu Val Glu Leu Asp Ile Ser Asn Thr Asp 
    290                 295                 300                 


Phe Ser Tyr Gln Pro Gly Asp Ala Phe Ser Val Ile Cys Pro Asn Ser 
305                 310                 315                 320 


Asp Ser Glu Val Gln Ser Leu Leu Gln Arg Leu Gln Leu Glu Asp Lys 
                325                 330                 335     


Arg Glu His Cys Val Leu Leu Lys Ile Lys Ala Asp Thr Lys Lys Lys 
            340                 345                 350         


Gly Ala Thr Leu Pro Gln His Ile Pro Ala Gly Cys Ser Leu Gln Phe 
        355                 360                 365             


Ile Phe Thr Trp Cys Leu Glu Ile Arg Ala Ile Pro Lys Lys Ala Phe 
    370                 375                 380                 


Leu Arg Ala Leu Val Asp Tyr Thr Ser Asp Ser Ala Glu Lys Arg Arg 
385                 390                 395                 400 


Leu Gln Glu Leu Cys Ser Lys Gln Gly Ala Ala Asp Tyr Ser Arg Phe 
                405                 410                 415     


Val Arg Asp Ala Cys Ala Cys Leu Leu Asp Leu Leu Leu Ala Phe Pro 
            420                 425                 430         


Ser Cys Gln Pro Pro Leu Ser Leu Leu Leu Glu His Leu Pro Lys Leu 
        435                 440                 445             


Gln Pro Arg Pro Tyr Ser Cys Ala Ser Ser Ser Leu Phe His Pro Gly 
    450                 455                 460                 


Lys Leu His Phe Val Phe Asn Ile Val Glu Phe Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Thr Glu Val Leu Arg Lys Gly Val Cys Thr Gly Trp Leu Ala Leu Leu 
                485                 490                 495     


Val Ala Ser Val Leu Gln Pro Asn Ile His Ala Ser His Glu Asp Ser 
            500                 505                 510         


Gly Lys Ala Leu Ala Pro Lys Ile Ser Ile Ser Pro Arg Thr Thr Asn 
        515                 520                 525             


Ser Phe His Leu Pro Asp Asp Pro Ser Ile Pro Ile Ile Met Val Gly 
    530                 535                 540                 


Pro Gly Thr Gly Ile Ala Pro Phe Ile Gly Phe Leu Gln His Arg Glu 
545                 550                 555                 560 


Lys Leu Gln Glu Gln His Pro Asp Gly Asn Phe Gly Ala Met Trp Leu 
                565                 570                 575     


Phe Phe Gly Cys Arg His Lys Asp Arg Asp Tyr Leu Phe Arg Lys Glu 
            580                 585                 590         


Leu Arg His Phe Leu Lys His Gly Ile Leu Thr His Leu Lys Val Ser 
        595                 600                 605             


Phe Ser Arg Asp Ala Pro Val Gly Glu Glu Glu Ala Pro Ala Lys Tyr 
    610                 615                 620                 


Val Gln Asp Asn Ile Gln Leu His Gly Gln Gln Val Ala Arg Ile Leu 
625                 630                 635                 640 


Leu Gln Glu Asn Gly His Ile Tyr Val Cys Gly Asp Ala Lys Asn Met 
                645                 650                 655     


Ala Lys Asp Val His Asp Ala Leu Val Gln Ile Ile Ser Lys Glu Val 
            660                 665                 670         


Gly Val Glu Lys Leu Glu Ala Met Lys Thr Leu Ala Thr Leu Lys Glu 
        675                 680                 685             


Glu Lys Arg Tyr Leu Gln Asp Ile Trp Ser 
    690                 695             


<210>  83
<211>  3661
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Ser Arg Arg Ala Pro Gly Ser Arg Leu Ser Ser Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Thr Lys Tyr Pro Arg Ser Trp Asn Asp Trp Gln Pro Arg Thr 
            20                  25                  30          


Asp Ser Ala Ser Ala Asp Pro Asp Asn Leu Lys Tyr Ser Ser Ser Arg 
        35                  40                  45              


Asp Arg Gly Gly Ser Ser Ser Tyr Gly Leu Gln Pro Ser Asn Ser Ala 
    50                  55                  60                  


Val Val Ser Arg Gln Arg His Asp Asp Thr Arg Val His Ala Asp Ile 
65                  70                  75                  80  


Gln Asn Asp Glu Lys Gly Gly Tyr Ser Val Asn Gly Gly Ser Gly Glu 
                85                  90                  95      


Asn Thr Tyr Gly Arg Lys Ser Leu Gly Gln Glu Leu Arg Val Asn Asn 
            100                 105                 110         


Val Thr Ser Pro Glu Phe Thr Ser Val Gln His Gly Ser Arg Ala Leu 
        115                 120                 125             


Ala Thr Lys Asp Met Arg Lys Ser Gln Glu Arg Ser Met Ser Tyr Ser 
    130                 135                 140                 


Asp Glu Ser Arg Leu Ser Asn Leu Leu Arg Arg Ile Thr Arg Glu Asp 
145                 150                 155                 160 


Asp Arg Asp Arg Arg Leu Ala Thr Val Lys Gln Leu Lys Glu Phe Ile 
                165                 170                 175     


Gln Gln Pro Glu Asn Lys Leu Val Leu Val Lys Gln Leu Asp Asn Ile 
            180                 185                 190         


Leu Ala Ala Val His Asp Val Leu Asn Glu Ser Ser Lys Leu Leu Gln 
        195                 200                 205             


Glu Leu Arg Gln Glu Gly Ala Cys Cys Leu Gly Leu Leu Cys Ala Ser 
    210                 215                 220                 


Leu Ser Tyr Glu Ala Glu Lys Ile Phe Lys Trp Ile Phe Ser Lys Phe 
225                 230                 235                 240 


Ser Ser Ser Ala Lys Asp Glu Val Lys Leu Leu Tyr Leu Cys Ala Thr 
                245                 250                 255     


Tyr Lys Ala Leu Glu Thr Val Gly Glu Lys Lys Ala Phe Ser Ser Val 
            260                 265                 270         


Met Gln Leu Val Met Thr Ser Leu Gln Ser Ile Leu Glu Asn Val Asp 
        275                 280                 285             


Thr Pro Glu Leu Leu Cys Lys Cys Val Lys Cys Ile Leu Leu Val Ala 
    290                 295                 300                 


Arg Cys Tyr Pro His Ile Phe Ser Thr Asn Phe Arg Asp Thr Val Asp 
305                 310                 315                 320 


Ile Leu Val Gly Trp His Ile Asp His Thr Gln Lys Pro Ser Leu Thr 
                325                 330                 335     


Gln Gln Val Ser Gly Trp Leu Gln Ser Leu Glu Pro Phe Trp Val Ala 
            340                 345                 350         


Asp Leu Ala Phe Ser Thr Thr Leu Leu Gly Gln Phe Leu Glu Asp Met 
        355                 360                 365             


Glu Ala Tyr Ala Glu Asp Leu Ser His Val Ala Ser Gly Glu Ser Val 
    370                 375                 380                 


Asp Glu Asp Val Pro Pro Pro Ser Val Ser Leu Pro Lys Leu Ala Ala 
385                 390                 395                 400 


Leu Leu Arg Val Phe Ser Thr Val Val Arg Ser Ile Gly Glu Arg Phe 
                405                 410                 415     


Ser Pro Ile Arg Gly Pro Pro Ile Thr Glu Ala Tyr Val Thr Asp Val 
            420                 425                 430         


Leu Tyr Arg Val Met Arg Cys Val Thr Ala Ala Asn Gln Val Phe Phe 
        435                 440                 445             


Ser Glu Ala Val Leu Thr Ala Ala Asn Glu Cys Val Gly Val Leu Leu 
    450                 455                 460                 


Gly Ser Leu Asp Pro Ser Met Thr Ile His Cys Asp Met Val Ile Thr 
465                 470                 475                 480 


Tyr Gly Leu Asp Gln Leu Glu Asn Cys Gln Thr Cys Gly Thr Asp Tyr 
                485                 490                 495     


Ile Ile Ser Val Leu Asn Leu Leu Thr Leu Ile Val Glu Gln Ile Asn 
            500                 505                 510         


Thr Lys Leu Pro Ser Ser Phe Val Glu Lys Leu Phe Ile Pro Ser Ser 
        515                 520                 525             


Lys Leu Leu Phe Leu Arg Tyr His Lys Glu Lys Glu Val Val Ala Val 
    530                 535                 540                 


Ala His Ala Val Tyr Gln Ala Val Leu Ser Leu Lys Asn Ile Pro Val 
545                 550                 555                 560 


Leu Glu Thr Ala Tyr Lys Leu Ile Leu Gly Glu Met Thr Cys Ala Leu 
                565                 570                 575     


Asn Asn Leu Leu His Ser Leu Gln Leu Pro Glu Ala Cys Ser Glu Ile 
            580                 585                 590         


Lys His Glu Ala Phe Lys Asn His Val Phe Asn Val Asp Asn Ala Lys 
        595                 600                 605             


Phe Val Val Ile Phe Asp Leu Ser Ala Leu Thr Thr Ile Gly Asn Ala 
    610                 615                 620                 


Lys Asn Ser Leu Ile Gly Met Trp Ala Leu Ser Pro Thr Val Phe Ala 
625                 630                 635                 640 


Leu Leu Ser Lys Asn Leu Met Ile Val His Ser Asp Leu Ala Val His 
                645                 650                 655     


Phe Pro Ala Ile Gln Tyr Ala Val Leu Tyr Thr Leu Tyr Ser His Cys 
            660                 665                 670         


Thr Arg His Asp His Phe Ile Ser Ser Ser Leu Ser Ser Ser Ser Pro 
        675                 680                 685             


Ser Leu Phe Asp Gly Ala Val Ile Ser Thr Val Thr Thr Ala Thr Lys 
    690                 695                 700                 


Lys His Phe Ser Ile Ile Leu Asn Leu Leu Gly Ile Leu Leu Lys Lys 
705                 710                 715                 720 


Asp Asn Leu Asn Gln Asp Thr Arg Lys Leu Leu Met Thr Trp Ala Leu 
                725                 730                 735     


Glu Ala Ala Val Leu Met Lys Lys Ser Glu Thr Tyr Ala Pro Leu Phe 
            740                 745                 750         


Ser Leu Pro Ser Phe His Lys Phe Cys Lys Gly Leu Leu Ala Asn Thr 
        755                 760                 765             


Leu Val Glu Asp Val Asn Ile Cys Leu Gln Ala Cys Ser Ser Leu His 
    770                 775                 780                 


Ala Leu Ser Ser Ser Leu Pro Asp Asp Leu Leu Gln Arg Cys Val Asp 
785                 790                 795                 800 


Val Cys Arg Val Gln Leu Val His Ser Gly Thr Arg Ile Arg Gln Ala 
                805                 810                 815     


Phe Gly Lys Leu Leu Lys Ser Ile Pro Leu Asp Val Val Leu Ser Asn 
            820                 825                 830         


Asn Asn His Thr Glu Ile Gln Glu Ile Ser Leu Ala Leu Arg Ser His 
        835                 840                 845             


Met Ser Lys Ala Pro Ser Asn Thr Phe His Pro Gln Asp Phe Ser Asp 
    850                 855                 860                 


Val Ile Ser Phe Ile Leu Tyr Gly Asn Ser His Arg Thr Gly Lys Asp 
865                 870                 875                 880 


Asn Trp Leu Glu Arg Leu Phe Tyr Ser Cys Gln Arg Leu Asp Lys Arg 
                885                 890                 895     


Asp Gln Ser Thr Ile Pro Arg Asn Leu Leu Lys Thr Asp Ala Val Leu 
            900                 905                 910         


Trp Gln Trp Ala Ile Trp Glu Ala Ala Gln Phe Thr Val Leu Ser Lys 
        915                 920                 925             


Leu Arg Thr Pro Leu Gly Arg Ala Gln Asp Thr Phe Gln Thr Ile Glu 
    930                 935                 940                 


Gly Ile Ile Arg Ser Leu Ala Ala His Thr Leu Asn Pro Asp Gln Asp 
945                 950                 955                 960 


Val Ser Gln Trp Thr Thr Ala Asp Asn Asp Glu Gly His Gly Asn Asn 
                965                 970                 975     


Gln Leu Arg Leu Val Leu Leu Leu Gln Tyr Leu Glu Asn Leu Glu Lys 
            980                 985                 990         


Leu Met Tyr Asn Ala Tyr Glu Gly  Cys Ala Asn Ala Leu  Thr Ser Pro 
        995                 1000                 1005             


Pro Lys  Val Ile Arg Thr Phe  Phe Tyr Thr Asn Arg  Gln Thr Cys 
    1010                 1015                 1020             


Gln Asp  Trp Leu Thr Arg Ile  Arg Leu Ser Ile Met  Arg Val Gly 
    1025                 1030                 1035             


Leu Leu  Ala Gly Gln Pro Ala  Val Thr Val Arg His  Gly Phe Asp 
    1040                 1045                 1050             


Leu Leu  Thr Glu Met Lys Thr  Thr Ser Leu Ser Gln  Gly Asn Glu 
    1055                 1060                 1065             


Leu Glu  Val Thr Ile Met Met  Val Val Glu Ala Leu  Cys Glu Leu 
    1070                 1075                 1080             


His Cys  Pro Glu Ala Ile Gln  Gly Ile Ala Val Trp  Ser Ser Ser 
    1085                 1090                 1095             


Ile Val  Gly Lys Asn Leu Leu  Trp Ile Asn Ser Val  Ala Gln Gln 
    1100                 1105                 1110             


Ala Glu  Gly Arg Phe Glu Lys  Ala Ser Val Glu Tyr  Gln Glu His 
    1115                 1120                 1125             


Leu Cys  Ala Met Thr Gly Val  Asp Cys Cys Ile Ser  Ser Phe Asp 
    1130                 1135                 1140             


Lys Ser  Val Leu Thr Leu Ala  Asn Ala Gly Arg Asn  Ser Ala Ser 
    1145                 1150                 1155             


Pro Lys  His Ser Leu Asn Gly  Glu Ser Arg Lys Thr  Val Leu Ser 
    1160                 1165                 1170             


Lys Pro  Thr Asp Ser Ser Pro  Glu Val Ile Asn Tyr  Leu Gly Asn 
    1175                 1180                 1185             


Lys Ala  Cys Glu Cys Tyr Ile  Ser Ile Ala Asp Trp  Ala Ala Val 
    1190                 1195                 1200             


Gln Glu  Trp Gln Asn Ala Ile  His Asp Leu Lys Lys  Ser Thr Ser 
    1205                 1210                 1215             


Ser Thr  Ser Leu Asn Leu Lys  Ala Asp Phe Asn Tyr  Ile Lys Ser 
    1220                 1225                 1230             


Leu Ser  Ser Phe Glu Ser Gly  Lys Phe Val Glu Cys  Thr Glu Gln 
    1235                 1240                 1245             


Leu Glu  Leu Leu Pro Gly Glu  Asn Ile Asn Leu Leu  Ala Gly Gly 
    1250                 1255                 1260             


Ser Lys  Glu Lys Ile Asp Met  Lys Lys Leu Leu Pro  Asn Met Leu 
    1265                 1270                 1275             


Ser Pro  Asp Pro Arg Glu Leu  Gln Lys Ser Ile Glu  Val Gln Leu 
    1280                 1285                 1290             


Leu Arg  Ser Ser Val Cys Leu  Ala Thr Ala Leu Asn  Pro Ile Glu 
    1295                 1300                 1305             


Gln Asp  Gln Lys Trp Gln Ser  Ile Thr Glu Asn Val  Val Lys Tyr 
    1310                 1315                 1320             


Leu Lys  Gln Thr Ser Arg Ile  Ala Ile Gly Pro Leu  Arg Leu Ser 
    1325                 1330                 1335             


Thr Leu  Thr Val Ser Gln Ser  Leu Pro Val Leu Ser  Thr Leu Gln 
    1340                 1345                 1350             


Leu Tyr  Cys Ser Ser Ala Leu  Glu Asn Thr Val Ser  Asn Arg Leu 
    1355                 1360                 1365             


Ser Thr  Glu Asp Cys Leu Ile  Pro Leu Phe Ser Glu  Ala Leu Arg 
    1370                 1375                 1380             


Ser Cys  Lys Gln His Asp Val  Arg Pro Trp Met Gln  Ala Leu Arg 
    1385                 1390                 1395             


Tyr Thr  Met Tyr Gln Asn Gln  Leu Leu Glu Lys Ile  Lys Glu Gln 
    1400                 1405                 1410             


Thr Val  Pro Ile Arg Ser His  Leu Met Glu Leu Gly  Leu Thr Ala 
    1415                 1420                 1425             


Ala Lys  Phe Ala Arg Lys Arg  Gly Asn Val Ser Leu  Ala Thr Arg 
    1430                 1435                 1440             


Leu Leu  Ala Gln Cys Ser Glu  Val Gln Leu Gly Lys  Thr Thr Thr 
    1445                 1450                 1455             


Ala Gln  Asp Leu Val Gln His  Phe Lys Lys Leu Ser  Thr Gln Gly 
    1460                 1465                 1470             


Gln Val  Asp Glu Lys Trp Gly  Pro Glu Leu Asp Ile  Glu Lys Thr 
    1475                 1480                 1485             


Lys Leu  Leu Tyr Thr Ala Gly  Gln Ser Thr His Ala  Met Glu Met 
    1490                 1495                 1500             


Leu Ser  Ser Cys Ala Ile Ser  Phe Cys Lys Ser Val  Lys Ala Glu 
    1505                 1510                 1515             


Tyr Ala  Val Ala Lys Ser Ile  Leu Thr Leu Ala Lys  Trp Ile Gln 
    1520                 1525                 1530             


Ala Glu  Trp Lys Glu Ile Ser  Gly Gln Leu Lys Gln  Val Tyr Arg 
    1535                 1540                 1545             


Ala Gln  His Gln Gln Asn Phe  Thr Gly Leu Ser Thr  Leu Ser Lys 
    1550                 1555                 1560             


Asn Ile  Leu Thr Leu Ile Glu  Leu Pro Ser Val Asn  Thr Met Glu 
    1565                 1570                 1575             


Glu Glu  Tyr Pro Arg Ile Glu  Ser Glu Ser Thr Val  His Ile Gly 
    1580                 1585                 1590             


Val Gly  Glu Pro Asp Phe Ile  Leu Gly Gln Leu Tyr  His Leu Ser 
    1595                 1600                 1605             


Ser Val  Gln Ala Pro Glu Val  Ala Lys Ser Trp Ala  Ala Leu Ala 
    1610                 1615                 1620             


Ser Trp  Ala Tyr Arg Trp Gly  Arg Lys Val Val Asp  Asn Ala Ser 
    1625                 1630                 1635             


Gln Gly  Glu Gly Val Arg Leu  Leu Pro Arg Glu Lys  Ser Glu Val 
    1640                 1645                 1650             


Gln Asn  Leu Leu Pro Asp Thr  Ile Thr Glu Glu Glu  Lys Glu Arg 
    1655                 1660                 1665             


Ile Tyr  Gly Ile Leu Gly Gln  Ala Val Cys Arg Pro  Ala Gly Ile 
    1670                 1675                 1680             


Gln Asp  Glu Asp Ile Thr Leu  Gln Ile Thr Glu Ser  Glu Asp Asn 
    1685                 1690                 1695             


Glu Glu  Asp Asp Met Val Asp  Val Ile Trp Arg Gln  Leu Ile Ser 
    1700                 1705                 1710             


Ser Cys  Pro Trp Leu Ser Glu  Leu Asp Glu Ser Ala  Thr Glu Gly 
    1715                 1720                 1725             


Val Ile  Lys Val Trp Arg Lys  Val Val Asp Arg Ile  Phe Ser Leu 
    1730                 1735                 1740             


Tyr Lys  Leu Ser Cys Ser Ala  Tyr Phe Thr Phe Leu  Lys Leu Asn 
    1745                 1750                 1755             


Ala Gly  Gln Ile Pro Leu Asp  Glu Asp Asp Pro Arg  Leu His Leu 
    1760                 1765                 1770             


Ser His  Arg Val Glu Gln Ser  Thr Asp Asp Met Ile  Val Met Ala 
    1775                 1780                 1785             


Thr Leu  Arg Leu Leu Arg Leu  Leu Val Lys His Ala  Gly Glu Leu 
    1790                 1795                 1800             


Arg Gln  Tyr Leu Glu His Gly  Leu Glu Thr Thr Pro  Thr Ala Pro 
    1805                 1810                 1815             


Trp Arg  Gly Ile Ile Pro Gln  Leu Phe Ser Arg Leu  Asn His Pro 
    1820                 1825                 1830             


Glu Val  Tyr Val Arg Gln Ser  Ile Cys Asn Leu Leu  Cys Arg Val 
    1835                 1840                 1845             


Ala Gln  Asp Ser Pro His Leu  Ile Leu Tyr Pro Ala  Ile Val Gly 
    1850                 1855                 1860             


Thr Ile  Ser Leu Ser Ser Glu  Ser Gln Ala Ser Gly  Asn Lys Phe 
    1865                 1870                 1875             


Ser Thr  Ala Ile Pro Thr Leu  Leu Gly Asn Ile Gln  Gly Glu Glu 
    1880                 1885                 1890             


Leu Leu  Val Ser Glu Cys Glu  Gly Gly Ser Pro Pro  Ala Ser Gln 
    1895                 1900                 1905             


Asp Ser  Asn Lys Asp Glu Pro  Lys Ser Gly Leu Asn  Glu Asp Gln 
    1910                 1915                 1920             


Ala Met  Met Gln Asp Cys Tyr  Ser Lys Ile Val Asp  Lys Leu Ser 
    1925                 1930                 1935             


Ser Ala  Asn Pro Thr Met Val  Leu Gln Val Gln Met  Leu Val Ala 
    1940                 1945                 1950             


Glu Leu  Arg Arg Val Thr Val  Leu Trp Asp Glu Leu  Trp Leu Gly 
    1955                 1960                 1965             


Val Leu  Leu Gln Gln His Met  Tyr Val Leu Arg Arg  Ile Gln Gln 
    1970                 1975                 1980             


Leu Glu  Asp Glu Val Lys Arg  Val Gln Asn Asn Asn  Thr Leu Arg 
    1985                 1990                 1995             


Lys Glu  Glu Lys Ile Ala Ile  Met Arg Glu Lys His  Thr Ala Leu 
    2000                 2005                 2010             


Met Lys  Pro Ile Val Phe Ala  Leu Glu His Val Arg  Ser Ile Thr 
    2015                 2020                 2025             


Ala Ala  Pro Ala Glu Thr Pro  His Glu Lys Trp Phe  Gln Asp Asn 
    2030                 2035                 2040             


Tyr Gly  Asp Ala Ile Glu Asn  Ala Leu Glu Lys Leu  Lys Thr Pro 
    2045                 2050                 2055             


Leu Asn  Pro Ala Lys Pro Gly  Ser Ser Trp Ile Pro  Phe Lys Glu 
    2060                 2065                 2070             


Ile Met  Leu Ser Leu Gln Gln  Arg Ala Gln Lys Arg  Ala Ser Tyr 
    2075                 2080                 2085             


Ile Leu  Arg Leu Glu Glu Ile  Ser Pro Trp Leu Ala  Ala Met Thr 
    2090                 2095                 2100             


Asn Thr  Glu Ile Ala Leu Pro  Gly Glu Val Ser Ala  Arg Asp Thr 
    2105                 2110                 2115             


Val Thr  Ile His Ser Val Gly  Gly Thr Ile Thr Ile  Leu Pro Thr 
    2120                 2125                 2130             


Lys Thr  Lys Pro Lys Lys Leu  Leu Phe Leu Gly Ser  Asp Gly Lys 
    2135                 2140                 2145             


Ser Tyr  Pro Tyr Leu Phe Lys  Gly Leu Glu Asp Leu  His Leu Asp 
    2150                 2155                 2160             


Glu Arg  Ile Met Gln Phe Leu  Ser Ile Val Asn Thr  Met Phe Ala 
    2165                 2170                 2175             


Thr Ile  Asn Arg Gln Glu Thr  Pro Arg Phe His Ala  Arg His Tyr 
    2180                 2185                 2190             


Ser Val  Thr Pro Leu Gly Thr  Arg Ser Gly Leu Ile  Gln Trp Val 
    2195                 2200                 2205             


Asp Gly  Ala Thr Pro Leu Phe  Gly Leu Tyr Lys Arg  Trp Gln Gln 
    2210                 2215                 2220             


Arg Glu  Ala Ala Leu Gln Ala  Gln Lys Ala Gln Asp  Ser Tyr Gln 
    2225                 2230                 2235             


Thr Pro  Gln Asn Pro Gly Ile  Val Pro Arg Pro Ser  Glu Leu Tyr 
    2240                 2245                 2250             


Tyr Ser  Lys Ile Gly Pro Ala  Leu Lys Thr Val Gly  Leu Ser Leu 
    2255                 2260                 2265             


Asp Val  Ser Arg Arg Asp Trp  Pro Leu His Val Met  Lys Ala Val 
    2270                 2275                 2280             


Leu Glu  Glu Leu Met Glu Ala  Thr Pro Pro Asn Leu  Leu Ala Lys 
    2285                 2290                 2295             


Glu Leu  Trp Ser Ser Cys Thr  Thr Pro Asp Glu Trp  Trp Arg Val 
    2300                 2305                 2310             


Thr Gln  Ser Tyr Ala Arg Ser  Thr Ala Val Met Ser  Met Val Gly 
    2315                 2320                 2325             


Tyr Ile  Ile Gly Leu Gly Asp  Arg His Leu Asp Asn  Val Leu Ile 
    2330                 2335                 2340             


Asp Met  Thr Thr Gly Glu Val  Val His Ile Asp Tyr  Asn Val Cys 
    2345                 2350                 2355             


Phe Glu  Lys Gly Lys Ser Leu  Arg Val Pro Glu Lys  Val Pro Phe 
    2360                 2365                 2370             


Arg Met  Thr Gln Asn Ile Glu  Thr Ala Leu Gly Val  Thr Gly Val 
    2375                 2380                 2385             


Glu Gly  Val Phe Arg Leu Ser  Cys Glu Gln Val Leu  His Ile Met 
    2390                 2395                 2400             


Arg Arg  Gly Arg Glu Thr Leu  Leu Thr Leu Leu Glu  Ala Phe Val 
    2405                 2410                 2415             


Tyr Asp  Pro Leu Val Asp Trp  Thr Ala Gly Gly Glu  Ala Gly Phe 
    2420                 2425                 2430             


Ala Gly  Ala Val Tyr Gly Gly  Gly Gly Gln Gln Ala  Glu Ser Lys 
    2435                 2440                 2445             


Gln Ser  Lys Arg Glu Met Glu  Arg Glu Ile Thr Arg  Ser Leu Phe 
    2450                 2455                 2460             


Ser Ser  Arg Val Ala Glu Ile  Lys Val Asn Trp Phe  Lys Asn Arg 
    2465                 2470                 2475             


Asp Glu  Met Leu Val Val Leu  Pro Lys Leu Asp Gly  Ser Leu Asp 
    2480                 2485                 2490             


Glu Tyr  Leu Ser Leu Gln Glu  Gln Leu Thr Asp Val  Glu Lys Leu 
    2495                 2500                 2505             


Gln Gly  Lys Leu Leu Glu Glu  Ile Glu Phe Leu Glu  Gly Ala Glu 
    2510                 2515                 2520             


Gly Val  Asp His Pro Ser His  Thr Leu Gln His Arg  Tyr Ser Glu 
    2525                 2530                 2535             


His Thr  Gln Leu Gln Thr Gln  Gln Arg Ala Val Gln  Glu Ala Ile 
    2540                 2545                 2550             


Gln Val  Lys Leu Asn Glu Phe  Glu Gln Trp Ile Thr  His Tyr Gln 
    2555                 2560                 2565             


Ala Ala  Phe Asn Asn Leu Glu  Ala Thr Gln Leu Ala  Ser Leu Leu 
    2570                 2575                 2580             


Gln Glu  Ile Ser Thr Gln Met  Asp Leu Gly Pro Pro  Ser Tyr Val 
    2585                 2590                 2595             


Pro Ala  Thr Ala Phe Leu Gln  Asn Ala Gly Gln Ala  His Leu Ile 
    2600                 2605                 2610             


Ser Gln  Cys Glu Gln Leu Glu  Gly Glu Val Gly Ala  Leu Leu Gln 
    2615                 2620                 2625             


Gln Arg  Arg Ser Val Leu Arg  Gly Cys Leu Glu Gln  Leu His His 
    2630                 2635                 2640             


Tyr Ala  Thr Val Ala Leu Gln  Tyr Pro Lys Ala Ile  Phe Gln Lys 
    2645                 2650                 2655             


His Arg  Ile Glu Gln Trp Lys  Thr Trp Met Glu Glu  Leu Ile Cys 
    2660                 2665                 2670             


Asn Thr  Thr Val Glu Arg Cys  Gln Glu Leu Tyr Arg  Lys Tyr Glu 
    2675                 2680                 2685             


Met Gln  Tyr Ala Pro Gln Pro  Pro Pro Thr Val Cys  Gln Phe Ile 
    2690                 2695                 2700             


Thr Ala  Thr Glu Met Thr Leu  Gln Arg Tyr Ala Ala  Asp Ile Asn 
    2705                 2710                 2715             


Ser Arg  Leu Ile Arg Gln Val  Glu Arg Leu Lys Gln  Glu Ala Val 
    2720                 2725                 2730             


Thr Val  Pro Val Cys Glu Asp  Gln Leu Lys Glu Ile  Glu Arg Cys 
    2735                 2740                 2745             


Ile Lys  Val Phe Leu His Glu  Asn Gly Glu Glu Gly  Ser Leu Ser 
    2750                 2755                 2760             


Leu Ala  Ser Val Ile Ile Ser  Ala Leu Cys Thr Leu  Thr Arg Arg 
    2765                 2770                 2775             


Asn Leu  Met Met Glu Gly Ala  Ala Ser Ser Ala Gly  Glu Gln Leu 
    2780                 2785                 2790             


Val Asp  Leu Thr Ser Arg Asp  Gly Ala Trp Phe Leu  Glu Glu Leu 
    2795                 2800                 2805             


Cys Ser  Met Ser Gly Asn Val  Thr Cys Leu Val Gln  Leu Leu Lys 
    2810                 2815                 2820             


Gln Cys  His Leu Val Pro Gln  Asp Leu Asp Ile Pro  Asn Pro Met 
    2825                 2830                 2835             


Glu Ala  Ser Glu Thr Val His  Leu Ala Asn Gly Val  Tyr Thr Ser 
    2840                 2845                 2850             


Leu Gln  Glu Leu Asn Ser Asn  Phe Arg Gln Ile Ile  Phe Pro Glu 
    2855                 2860                 2865             


Ala Leu  Arg Cys Leu Met Lys  Gly Glu Tyr Thr Leu  Glu Ser Met 
    2870                 2875                 2880             


Leu His  Glu Leu Asp Gly Leu  Ile Glu Gln Thr Thr  Asp Gly Val 
    2885                 2890                 2895             


Pro Leu  Gln Thr Leu Val Glu  Ser Leu Gln Ala Tyr  Leu Arg Asn 
    2900                 2905                 2910             


Ala Ala  Met Gly Leu Glu Glu  Glu Thr His Ala His  Tyr Ile Asp 
    2915                 2920                 2925             


Val Ala  Arg Leu Leu His Ala  Gln Tyr Gly Glu Leu  Ile Gln Pro 
    2930                 2935                 2940             


Arg Asn  Gly Ser Val Asp Glu  Thr Pro Lys Met Ser  Ala Gly Gln 
    2945                 2950                 2955             


Met Leu  Leu Val Ala Phe Asp  Gly Met Phe Ala Gln  Val Glu Thr 
    2960                 2965                 2970             


Ala Phe  Ser Leu Leu Val Glu  Lys Leu Asn Lys Met  Glu Ile Pro 
    2975                 2980                 2985             


Ile Ala  Trp Arg Lys Ile Asp  Ile Ile Arg Glu Ala  Arg Ser Thr 
    2990                 2995                 3000             


Gln Val  Asn Phe Phe Asp Asp  Asp Asn His Arg Gln  Val Leu Glu 
    3005                 3010                 3015             


Glu Ile  Phe Phe Leu Lys Arg  Leu Gln Thr Ile Lys  Glu Phe Phe 
    3020                 3025                 3030             


Arg Leu  Cys Gly Thr Phe Ser  Lys Thr Leu Ser Gly  Ser Ser Ser 
    3035                 3040                 3045             


Leu Glu  Asp Gln Asn Thr Val  Asn Gly Pro Val Gln  Ile Val Asn 
    3050                 3055                 3060             


Val Lys  Thr Leu Phe Arg Asn  Ser Cys Phe Ser Glu  Asp Gln Met 
    3065                 3070                 3075             


Ala Lys  Pro Ile Lys Ala Phe  Thr Ala Asp Phe Val  Arg Gln Leu 
    3080                 3085                 3090             


Leu Ile  Gly Leu Pro Asn Gln  Ala Leu Gly Leu Thr  Leu Cys Ser 
    3095                 3100                 3105             


Phe Ile  Ser Ala Leu Gly Val  Asp Ile Ile Ala Gln  Val Glu Ala 
    3110                 3115                 3120             


Lys Asp  Phe Gly Ala Glu Ser  Lys Val Ser Val Asp  Asp Leu Cys 
    3125                 3130                 3135             


Lys Lys  Ala Val Glu His Asn  Ile Gln Ile Gly Lys  Phe Ser Gln 
    3140                 3145                 3150             


Leu Val  Met Asn Arg Ala Thr  Val Leu Ala Ser Ser  Tyr Asp Thr 
    3155                 3160                 3165             


Ala Trp  Lys Lys His Asp Leu  Val Arg Arg Leu Glu  Thr Ser Ile 
    3170                 3175                 3180             


Ser Ser  Cys Lys Thr Ser Leu  Gln Arg Val Gln Leu  His Ile Ala 
    3185                 3190                 3195             


Met Phe  Gln Trp Gln His Glu  Asp Leu Leu Ile Asn  Arg Pro Gln 
    3200                 3205                 3210             


Ala Met  Ser Val Thr Pro Pro  Pro Arg Ser Ala Ile  Leu Thr Ser 
    3215                 3220                 3225             


Met Lys  Lys Lys Leu His Thr  Leu Ser Gln Ile Glu  Thr Ser Ile 
    3230                 3235                 3240             


Ala Thr  Val Gln Glu Lys Leu  Ala Ala Leu Glu Ser  Ser Ile Glu 
    3245                 3250                 3255             


Gln Arg  Leu Lys Trp Ala Gly  Gly Ala Asn Pro Ala  Leu Ala Pro 
    3260                 3265                 3270             


Val Leu  Gln Asp Phe Glu Ala  Thr Ile Ala Glu Arg  Arg Asn Leu 
    3275                 3280                 3285             


Val Leu  Lys Glu Ser Gln Arg  Ala Ser Gln Val Thr  Phe Leu Cys 
    3290                 3295                 3300             


Ser Asn  Ile Ile His Phe Glu  Ser Leu Arg Thr Arg  Thr Ala Glu 
    3305                 3310                 3315             


Ala Leu  Asn Leu Asp Ala Ala  Leu Phe Glu Leu Ile  Lys Arg Cys 
    3320                 3325                 3330             


Gln Gln  Met Cys Ser Phe Ala  Ser Gln Phe Asn Ser  Ser Val Ser 
    3335                 3340                 3345             


Glu Leu  Glu Leu Arg Leu Leu  Gln Arg Val Asp Thr  Gly Leu Glu 
    3350                 3355                 3360             


His Pro  Ile Gly Ser Ser Glu  Trp Leu Leu Ser Ala  His Lys Gln 
    3365                 3370                 3375             


Leu Thr  Gln Asp Met Ser Thr  Gln Arg Ala Ile Gln  Thr Glu Lys 
    3380                 3385                 3390             


Glu Gln  Gln Ile Glu Thr Val  Cys Glu Thr Ile Gln  Asn Leu Val 
    3395                 3400                 3405             


Asp Asn  Ile Lys Thr Val Leu  Thr Gly His Asn Arg  Gln Leu Gly 
    3410                 3415                 3420             


Asp Val  Lys His Leu Leu Lys  Ala Met Ala Lys Asp  Glu Glu Ala 
    3425                 3430                 3435             


Ala Leu  Ala Asp Gly Glu Asp  Val Pro Tyr Glu Asn  Ser Val Arg 
    3440                 3445                 3450             


Gln Phe  Leu Gly Glu Tyr Lys  Ser Trp Gln Asp Asn  Ile Gln Thr 
    3455                 3460                 3465             


Val Leu  Phe Thr Leu Val Gln  Ala Met Gly Gln Val  Arg Ser Gln 
    3470                 3475                 3480             


Glu His  Val Glu Met Leu Gln  Glu Ile Thr Pro Thr  Leu Lys Glu 
    3485                 3490                 3495             


Leu Lys  Thr Gln Ser Gln Ser  Ile Tyr Asn Asn Leu  Val Ser Phe 
    3500                 3505                 3510             


Ala Ser  Pro Leu Val Thr Asp  Ala Thr Asn Glu Cys  Ser Ser Pro 
    3515                 3520                 3525             


Thr Ser  Ser Ala Thr Tyr Gln  Pro Ser Phe Ala Ala  Ala Val Arg 
    3530                 3535                 3540             


Ser Asn  Thr Gly Gln Lys Thr  Gln Pro Asp Val Met  Ser Gln Asn 
    3545                 3550                 3555             


Ala Arg  Lys Leu Ile Gln Lys  Asn Leu Ala Thr Ser  Ala Asp Thr 
    3560                 3565                 3570             


Pro Pro  Ser Thr Val Pro Gly  Thr Gly Lys Ser Val  Ala Cys Ser 
    3575                 3580                 3585             


Pro Lys  Lys Ala Val Arg Asp  Pro Lys Thr Gly Lys  Ala Val Gln 
    3590                 3595                 3600             


Glu Arg  Asn Ser Tyr Ala Val  Ser Val Trp Lys Arg  Val Lys Ala 
    3605                 3610                 3615             


Lys Leu  Glu Gly Arg Asp Val  Asp Pro Asn Arg Arg  Met Ser Val 
    3620                 3625                 3630             


Ala Glu  Gln Val Asp Tyr Val  Ile Lys Glu Ala Thr  Asn Leu Asp 
    3635                 3640                 3645             


Asn Leu  Ala Gln Leu Tyr Glu  Gly Trp Thr Ala Trp  Val 
    3650                 3655                 3660     


<210>  84
<211>  973
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Glu Thr Lys Val His Leu Phe Cys Gln Ala Glu Glu Asn Ile Asp 
1               5                   10                  15      


Leu Leu Asp Asp Gly Ser Asn Ser Phe Ala Thr Asp Leu Ser Ser Gly 
            20                  25                  30          


Thr Ile Asn His Lys Lys Tyr Ile Lys Phe Ser Lys Thr Ile Glu Lys 
        35                  40                  45              


Glu Ile Ser Pro Glu Ile Arg Ser Leu Ser Pro Glu Tyr Lys Lys Ile 
    50                  55                  60                  


Phe Glu Thr Ser Ile Ile Phe Cys Gly Glu Glu Lys Ser Ser Asp Phe 
65                  70                  75                  80  


Ser Gly Glu Lys Lys Val Gly Arg Lys Ser Leu Gln Val Gln Gln His 
                85                  90                  95      


Ser Lys Arg Thr Glu Ile Ile Pro Pro Phe Leu Lys Leu Ser Lys Glu 
            100                 105                 110         


Lys Val Thr Arg Lys Glu Asn Ser Leu Cys Lys Leu Pro Asn Gln Tyr 
        115                 120                 125             


Ser Val His Lys Thr Ser Ser Pro Leu Cys Thr Ser Ser Ala Ile Thr 
    130                 135                 140                 


Arg Glu Lys Glu Met Leu Ser Asn Leu Tyr Met Thr Leu Tyr Asp Glu 
145                 150                 155                 160 


Val Thr His Gly Tyr Leu His Ser Lys Glu Leu Ser Ala Leu His Lys 
                165                 170                 175     


Ala Cys Lys Ile Phe Ser Lys Ile Arg Ser Gly Lys Ile Tyr Val Asn 
            180                 185                 190         


Asp Leu Pro Val Ile Leu Cys Ile Leu Arg Ile Ser Ile Ser Asp Leu 
        195                 200                 205             


Glu Met Arg Gln Ala Leu Lys Thr Val Asp Ile Asp Ala Phe Gln Asp 
    210                 215                 220                 


Ala Leu Lys Ile Phe Cys Arg Ile Lys Gly Gly Arg Val Ser Thr Asp 
225                 230                 235                 240 


Asp Val Phe Ala Val Leu Asp Ser Met Gly Ile Pro Ile Asn Arg Glu 
                245                 250                 255     


Ile Leu Glu Glu Val Thr Lys His Thr Tyr Ile Asp Ser Asn His Met 
            260                 265                 270         


Val Asp Ile Gly Asp Ile Ile Phe Thr Leu Asn Glu Leu Gln Glu Gln 
        275                 280                 285             


Tyr Glu Asp Val Ser Ile Thr Glu Gly Ser Pro Leu Asn Glu Ile Thr 
    290                 295                 300                 


Ser Asp Arg Lys Leu Ser Ser Val Ala Gly Cys Tyr Leu Lys Tyr Lys 
305                 310                 315                 320 


Lys Lys Asn Ser Leu Ser Ser Lys Leu Pro Glu Pro Ser Ile Ser Lys 
                325                 330                 335     


Lys Leu Asn Lys Lys Ser Asn Gln Tyr Tyr Ser Lys Ile Met Glu Asn 
            340                 345                 350         


Asp Asp Leu Glu Ser Lys Arg Pro Lys Asn Thr Trp Gln Ile Arg Lys 
        355                 360                 365             


Phe Leu Gly Gly Val Gly Ser Ser Asn Val Gly Val Gln Glu Pro Tyr 
    370                 375                 380                 


Ser Lys Asn Gly Ile Asn Phe Lys Lys His Ser Glu Lys Gly Glu Ile 
385                 390                 395                 400 


His Asp Ser Lys Ser Lys Pro Gln Ser Leu Lys Ser Ser Thr Ser Leu 
                405                 410                 415     


Ser Lys Ser Leu Asp Lys Ser Asp Ile Ser Ser Ile Pro Lys Leu Gln 
            420                 425                 430         


Lys Pro Ala Val Arg Lys His Ser Ser Leu Gln Lys Gln Val Ser Ser 
        435                 440                 445             


Thr Glu Lys Thr Ala Ile Ser Thr Leu Glu Asn Phe Cys Glu Ala Ile 
    450                 455                 460                 


Ser Lys Leu Gln Glu Asn Tyr Ile Ala Ala Glu Glu Leu Gln Ser Ile 
465                 470                 475                 480 


Leu Pro Ser Thr Gly Ile Asn Leu Leu Asp Glu Glu Phe Gln Lys Ile 
                485                 490                 495     


Val Thr Asp Thr Ser Arg Asn Glu Asn Gly Met Val Glu Leu Asp Asp 
            500                 505                 510         


Phe Val Asn Ala Leu Ala Lys Glu Arg Ser Phe Pro Glu Cys Asn Ala 
        515                 520                 525             


Leu Pro Gly Val Ile Lys Ala Ile Asp Lys Ile Lys Asp Lys Asn Val 
    530                 535                 540                 


Asp Tyr Glu Asp Leu Asn Thr Cys Leu Gln Asn Phe Gly Ile Tyr Leu 
545                 550                 555                 560 


Ser Lys Pro Glu Phe Lys Lys Ile Thr Glu Leu Thr Glu Ala Gly Glu 
                565                 570                 575     


Thr Lys Lys Val Asn Phe Lys Glu Phe Ile Asp Thr Met Met Ser Asn 
            580                 585                 590         


Thr Glu Cys Phe Ser Glu Lys Leu Val Leu Pro Asp Ala Ile Glu Thr 
        595                 600                 605             


Leu Asp Asp Leu Arg Lys Glu Thr Met Ser Val Ser Asp Leu Trp Asn 
    610                 615                 620                 


Thr Leu Ser Ser Leu Asn Ser Asn Leu Lys Lys Asp Glu Phe Leu Ala 
625                 630                 635                 640 


Ala Leu Glu Leu Val Thr Val Asp Glu Gly Asp Lys Val Gln Phe Glu 
                645                 650                 655     


Glu Phe Ala Lys Val Val Arg Asn Met Arg Asp Ala Ala Arg Leu Glu 
            660                 665                 670         


Glu Leu Gln Glu Val Val Leu Ala Ala Asp Leu Leu Glu Gly Asp Met 
        675                 680                 685             


Ile Ala Gly Lys Asn Leu Glu Asp Phe Leu Arg Asn Val Gly Ile Lys 
    690                 695                 700                 


Ser Pro Lys Glu Glu Val Glu Lys Ile Leu Gln Ser Asp Phe Val Ser 
705                 710                 715                 720 


Glu Asp Asn Met Val Asn Ile Lys Asp Cys Met Arg Ala Leu Arg Asp 
                725                 730                 735     


Thr Gln Lys Phe Ser Asn Tyr Ile Asp Phe Arg Lys Glu Ala Ser Asn 
            740                 745                 750         


Leu Lys Leu Pro Lys Val Asn Glu Ile Lys Glu Ala Ala Asn Ile Leu 
        755                 760                 765             


Ser His Val Asp Asn Gly Lys Ile Gly Ile Pro Asp Leu Glu His Ala 
    770                 775                 780                 


Leu Lys Cys Leu Asn Val Asn Leu Thr Glu Glu Asp Phe Asn Glu Ala 
785                 790                 795                 800 


Leu Asn Cys Cys Asn Val Ser Asp Asn Met Glu Val Asp Leu Lys Asp 
                805                 810                 815     


Phe Leu Met Lys Met Lys Glu Ser Pro His Phe Gln Lys Ser Lys Ala 
            820                 825                 830         


Thr Gln Ile Leu Leu Ala Thr Thr Gln Ile Leu Gln Asn Asp Leu Val 
        835                 840                 845             


Asp Val Ser Asp Leu Lys Thr Leu Leu Met Asp Lys Asp Leu His Thr 
    850                 855                 860                 


Ala Asn Ala Ile Leu Thr Val Met Leu Arg His Val Pro Glu His Glu 
865                 870                 875                 880 


Ser Gly Lys Val Ser Ile Gln Glu Phe Met Thr Lys Leu Ser Asp Ile 
                885                 890                 895     


Leu Thr Ile Pro Lys Ala Ala Gly Lys Phe Tyr Leu Ile Cys Thr Tyr 
            900                 905                 910         


Cys Pro Asp Leu Glu Arg Gln Ala Val Val Tyr Met Leu Lys Thr Ile 
        915                 920                 925             


Gln Asp Ser Ile Val Lys Ala Gln Val Ser Lys Lys Gln Tyr Asn Met 
    930                 935                 940                 


Asn Ile Lys Gln His Lys Ile Ser Leu His Asn Phe Cys Leu Asn Ser 
945                 950                 955                 960 


Lys Ala Asn Ile Ala Lys Leu Asn Pro Asn Ser Lys Phe 
                965                 970             


<210>  85
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Lys Leu Leu Met Val Leu Met Leu Ala Ala Leu Ser Gln His Cys 
1               5                   10                  15      


Tyr Ala Gly Ser Gly Cys Pro Leu Leu Glu Asn Val Ile Ser Lys Thr 
            20                  25                  30          


Ile Asn Pro Gln Val Ser Lys Thr Glu Tyr Lys Glu Leu Leu Gln Glu 
        35                  40                  45              


Phe Ile Asp Asp Asn Ala Thr Thr Asn Ala Ile Asp Glu Leu Lys Glu 
    50                  55                  60                  


Cys Phe Leu Asn Gln Thr Asp Glu Thr Leu Ser Asn Val Glu Val Phe 
65                  70                  75                  80  


Met Gln Leu Ile Tyr Asp Ser Ser Leu Cys Asp Leu Phe 
                85                  90              


<210>  86
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Asp Asp Leu Met Leu Ser Pro Asp Asp Ile Glu Gln Trp Phe Thr 
1               5                   10                  15      


Glu Asp Pro Gly Pro Asp Glu Ala Pro Arg Met Pro Glu Ala Ala Pro 
            20                  25                  30          


Pro Val Ala Pro Ala Pro Ala Ala Pro Thr Pro Ala Ala Pro Ala Pro 
        35                  40                  45              


Ala Pro Ser Trp Pro Leu Ser Ser Ser Val Pro Ser Gln Lys Thr Tyr 
    50                  55                  60                  


Gln Gly Ser Tyr Gly Phe Arg Leu Gly Phe Leu His Ser Gly Thr Ala 
65                  70                  75                  80  


Lys Ser Val Thr Cys Thr Tyr Ser Pro Ala Leu Asn Lys Met Phe Cys 
                85                  90                  95      


Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp Ser Thr Pro 
            100                 105                 110         


Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys Gln Ser Gln 
        115                 120                 125             


His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu Arg Cys Ser 
    130                 135                 140                 


Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg Val Glu Gly 
145                 150                 155                 160 


Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe Arg His Ser 
                165                 170                 175     


Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp Cys Thr Thr 
            180                 185                 190         


Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn 
        195                 200                 205             


Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser Ser Gly Asn 
    210                 215                 220                 


Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala Cys Pro Gly 
225                 230                 235                 240 


Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys Gly Glu Pro 
                245                 250                 255     


His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu Pro Asn Asn 
            260                 265                 270         


Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp Gly Glu Tyr 
        275                 280                 285             


Phe Thr Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu 
    290                 295                 300                 


Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro 
305                 310                 315                 320 


Gly Gly Ser Arg Ala His Ser Arg Glu Cys Gln Thr Leu Ser Pro Gly 
                325                 330                 335     


Asp Pro Asp Pro Pro Leu Ser Glu Thr Phe Asn Leu Asn Ile Cys Pro 
            340                 345                 350         


Tyr Pro Ala Gly Lys Leu Glu Leu Leu Lys Leu Ser Pro Cys Pro Cys 
        355                 360                 365             


Leu Cys Arg Gln Val Thr Leu Met Ser Phe Leu Phe Phe Phe Leu Ile 
    370                 375                 380                 


Phe Phe Tyr Phe Arg Leu Tyr Trp Gly Ile Ile Asp Pro Pro Lys Leu 
385                 390                 395                 400 


His Thr Phe Lys Val Cys Ser Val Met Ile 
                405                 410 


<210>  87
<211>  979
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Asp Asn Tyr Leu Ser Thr Asp Val 
            20                  25                  30          


Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln Glu Val Thr Ala 
        35                  40                  45              


Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys Pro Cys Ala Arg 
    50                  55                  60                  


Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu Val Arg Ala Val 
65                  70                  75                  80  


Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys Lys Ile Phe Gly 
                85                  90                  95      


Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp Pro Ala Ser Asn 
            100                 105                 110         


Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe Glu Thr Leu Glu 
        115                 120                 125             


Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Asp Ser Leu Pro 
    130                 135                 140                 


Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg Gly Arg Ile Leu 
145                 150                 155                 160 


His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly Ile Ser Trp 
                165                 170                 175     


Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu Ala Leu Ile 
            180                 185                 190         


His His Asn Thr His Leu Cys Phe Val His Thr Val Pro Trp Asp Gln 
        195                 200                 205             


Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr Ala Asn Arg Pro 
    210                 215                 220                 


Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His Gln Leu Cys Ala 
225                 230                 235                 240 


Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys Val Asn Cys Ser 
                245                 250                 255     


Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys Arg Val Leu Gln 
            260                 265                 270         


Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys Leu Pro Cys His 
        275                 280                 285             


Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys Phe Gly Pro Glu 
    290                 295                 300                 


Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp Pro Pro Phe Cys 
305                 310                 315                 320 


Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Tyr Met Pro 
                325                 330                 335     


Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln Pro Cys Pro Ile 
            340                 345                 350         


Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys Gly Cys Pro Ala 
        355                 360                 365             


Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser Ala Val Val Gly 
    370                 375                 380                 


Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly Ile Leu Ile Lys 
385                 390                 395                 400 


Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg Arg Leu Leu Gln 
                405                 410                 415     


Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Ala Met Pro Asn 
            420                 425                 430         


Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu Arg Lys Val Lys 
        435                 440                 445             


Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile Trp Ile 
    450                 455                 460                 


Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile Lys Val Leu Arg 
465                 470                 475                 480 


Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr 
                485                 490                 495     


Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg Leu Leu Gly Ile 
            500                 505                 510         


Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu Met Pro Tyr Gly 
        515                 520                 525             


Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg Leu Gly Ser Gln 
    530                 535                 540                 


Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly Met Ser Tyr Leu 
545                 550                 555                 560 


Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu 
                565                 570                 575     


Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe Gly Leu Ala Arg 
            580                 585                 590         


Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp Gly Gly Lys Val 
        595                 600                 605             


Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg Arg Arg Phe Thr 
    610                 615                 620                 


His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met 
625                 630                 635                 640 


Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala Arg Glu Ile Pro 
                645                 650                 655     


Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr 
            660                 665                 670         


Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met Ile Asp Ser Glu 
        675                 680                 685             


Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe Ser Arg Met Ala 
    690                 695                 700                 


Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu Asp Leu Gly Pro 
705                 710                 715                 720 


Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg Ser Leu Leu Glu Asp Asp 
                725                 730                 735     


Asp Met Gly Asp Leu Val Asp Ala Glu Glu Tyr Leu Val Pro Gln Gln 
            740                 745                 750         


Gly Phe Phe Cys Pro Asp Pro Ala Pro Gly Ala Gly Gly Met Val His 
        755                 760                 765             


His Arg His Arg Ser Ser Ser Thr Arg Ser Gly Gly Gly Asp Leu Thr 
    770                 775                 780                 


Leu Gly Leu Glu Pro Ser Glu Glu Glu Ala Pro Arg Ser Pro Leu Ala 
785                 790                 795                 800 


Pro Ser Glu Gly Ala Gly Ser Asp Val Phe Asp Gly Asp Leu Gly Met 
                805                 810                 815     


Gly Ala Ala Lys Gly Leu Gln Ser Leu Pro Thr His Asp Pro Ser Pro 
            820                 825                 830         


Leu Gln Arg Tyr Ser Glu Asp Pro Thr Val Pro Leu Pro Ser Glu Thr 
        835                 840                 845             


Asp Gly Tyr Val Ala Pro Leu Thr Cys Ser Pro Gln Pro Glu Tyr Val 
    850                 855                 860                 


Asn Gln Pro Asp Val Arg Pro Gln Pro Pro Ser Pro Arg Glu Gly Pro 
865                 870                 875                 880 


Leu Pro Ala Ala Arg Pro Ala Gly Ala Thr Leu Glu Arg Pro Lys Thr 
                885                 890                 895     


Leu Ser Pro Gly Lys Asn Gly Val Val Lys Asp Val Phe Ala Phe Gly 
            900                 905                 910         


Gly Ala Val Glu Asn Pro Glu Tyr Leu Thr Pro Gln Gly Gly Ala Ala 
        915                 920                 925             


Pro Gln Pro His Pro Pro Pro Ala Phe Ser Pro Ala Phe Asp Asn Leu 
    930                 935                 940                 


Tyr Tyr Trp Asp Gln Asp Pro Pro Glu Arg Gly Ala Pro Pro Ser Thr 
945                 950                 955                 960 


Phe Lys Gly Thr Pro Thr Ala Glu Asn Pro Glu Tyr Leu Gly Leu Asp 
                965                 970                 975     


Val Pro Val 
            


<210>  88
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Asn Gly Asp Asp Ala Phe Ala Arg Arg Pro Thr Val Gly Ala Gln 
1               5                   10                  15      


Ile Pro Glu Lys Ile Gln Lys Ala Phe Asp Asp Ile Ala Lys Tyr Phe 
            20                  25                  30          


Ser Lys Glu Glu Trp Glu Lys Met Lys Ala Ser Glu Lys Ile Phe Tyr 
        35                  40                  45              


Val Tyr Met Lys Arg Lys Tyr Glu Ala Met Thr Lys Leu Gly Phe Lys 
    50                  55                  60                  


Ala Thr Leu Pro Pro Phe Met Cys Asn Lys Arg Ala Glu Asp Phe Gln 
65                  70                  75                  80  


Gly Asn Asp Leu Asp Asn Asp Pro Asn Arg Gly Asn Gln Val Glu Arg 
                85                  90                  95      


Pro Gln Met Thr Phe Gly Arg Leu Gln Gly Ile Ser Pro Lys Ile Met 
            100                 105                 110         


Pro Lys Lys Pro Ala Glu Glu Gly Asn Asp Ser Glu Glu Val Pro Glu 
        115                 120                 125             


Ala Ser Gly Pro Gln Asn Asp Gly Lys Glu Leu Cys Pro Pro Gly Lys 
    130                 135                 140                 


Pro Thr Thr Ser Glu Lys Ile His Glu Arg Ser Gly Pro Lys Arg Gly 
145                 150                 155                 160 


Glu His Ala Trp Thr His Arg Leu Arg Glu Arg Lys Gln Leu Val Ile 
                165                 170                 175     


Tyr Glu Glu Ile Ser Asp Pro Glu Glu Asp Asp Glu 
            180                 185             


<210>  89
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 
                325                 330                 335     


Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 
            340                 345                 350         


Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His 
        355                 360                 365             


Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met 
    370                 375                 380                 


Phe Lys Thr Glu Gly Pro Asp Ser Asp 
385                 390             


<210>  90
<211>  642
<212>  PRT
<213>  Homo sapiens

<400>  90

Gly Met Ala Lys Ala Ala Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr 
1               5                   10                  15      


Ser Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn 
            20                  25                  30          


Asp Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr 
        35                  40                  45              


Glu Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Leu Asn Pro 
    50                  55                  60                  


Gln Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Gly 
65                  70                  75                  80  


Asp Pro Val Val Gln Ser Asp Met Lys His Trp Pro Phe Gln Val Ile 
                85                  90                  95      


Asn Asp Gly Asp Lys Pro Lys Val Gln Val Ser Tyr Lys Gly Glu Thr 
            100                 105                 110         


Lys Ala Phe Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys Met 
        115                 120                 125             


Lys Glu Ile Ala Glu Ala Tyr Leu Gly Tyr Pro Val Thr Asn Ala Val 
    130                 135                 140                 


Ile Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys 
145                 150                 155                 160 


Asp Ala Gly Val Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu 
                165                 170                 175     


Pro Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Arg Thr Gly Lys Gly 
            180                 185                 190         


Glu Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val 
        195                 200                 205             


Ser Ile Leu Thr Ile Asp Asp Gly Ile Phe Glu Val Lys Ala Thr Ala 
    210                 215                 220                 


Gly Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val Asn 
225                 230                 235                 240 


His Phe Val Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Gln 
                245                 250                 255     


Asn Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys 
            260                 265                 270         


Arg Thr Leu Ser Ser Ser Thr Gln Ala Ser Leu Glu Ile Asp Ser Leu 
        275                 280                 285             


Phe Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu 
    290                 295                 300                 


Glu Leu Cys Ser Asp Leu Phe Arg Ser Thr Leu Glu Pro Val Glu Lys 
305                 310                 315                 320 


Ala Leu Arg Asp Ala Lys Leu Asp Lys Ala Gln Ile His Asp Leu Val 
                325                 330                 335     


Leu Val Gly Gly Ser Thr Arg Ile Pro Lys Val Gln Lys Leu Leu Gln 
            340                 345                 350         


Asp Phe Phe Asn Gly Arg Asp Leu Asn Lys Ser Ile Asn Pro Asp Glu 
        355                 360                 365             


Ala Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Met Gly Asp 
    370                 375                 380                 


Lys Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Ala Pro Leu 
385                 390                 395                 400 


Ser Leu Gly Leu Glu Thr Ala Gly Gly Val Met Thr Ala Leu Ile Lys 
                405                 410                 415     


Arg Asn Ser Thr Ile Pro Thr Lys Gln Thr Gln Ile Phe Thr Thr Tyr 
            420                 425                 430         


Ser Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg 
        435                 440                 445             


Ala Met Thr Lys Asp Asn Asn Leu Leu Gly Arg Phe Glu Leu Ser Gly 
    450                 455                 460                 


Ile Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp 
465                 470                 475                 480 


Ile Asp Ala Asn Gly Ile Leu Asn Val Thr Ala Thr Asp Lys Ser Thr 
                485                 490                 495     


Gly Lys Ala Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser 
            500                 505                 510         


Lys Glu Glu Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala 
        515                 520                 525             


Glu Asp Glu Val Gln Arg Glu Arg Val Ser Ala Lys Asn Ala Leu Glu 
    530                 535                 540                 


Ser Tyr Ala Phe Asn Met Lys Ser Ala Val Glu Asp Glu Gly Leu Lys 
545                 550                 555                 560 


Gly Lys Ile Ser Glu Ala Asp Lys Lys Lys Val Leu Asp Lys Cys Gln 
                565                 570                 575     


Glu Val Ile Ser Trp Leu Asp Ala Asn Thr Leu Ala Glu Lys Asp Glu 
            580                 585                 590         


Phe Glu His Lys Arg Lys Glu Leu Glu Gln Val Cys Asn Pro Ile Ile 
        595                 600                 605             


Ser Gly Leu Tyr Gln Gly Ala Gly Gly Pro Gly Pro Gly Gly Phe Gly 
    610                 615                 620                 


Ala Gln Gly Pro Lys Gly Gly Ser Gly Ser Gly Pro Thr Ile Glu Glu 
625                 630                 635                 640 


Val Asp 
        


<210>  91
<211>  98
<212>  PRT
<213>  Alphapapillomavirus

<400>  91

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln 
                85                  90                  95      


Lys Pro 
        


<210>  92
<211>  158
<212>  PRT
<213>  Alphapapillomavirus

<400>  92

Met His Gln Lys Arg Thr Ala Met Phe Gln Asp Pro Gln Glu Arg Pro 
1               5                   10                  15      


Arg Lys Leu Pro Gln Leu Cys Thr Glu Leu Gln Thr Thr Ile His Asp 
            20                  25                  30          


Ile Ile Leu Glu Cys Val Tyr Cys Lys Gln Gln Leu Leu Arg Arg Glu 
        35                  40                  45              


Val Tyr Asp Phe Ala Phe Arg Asp Leu Cys Ile Val Tyr Arg Asp Gly 
    50                  55                  60                  


Asn Pro Tyr Ala Val Cys Asp Lys Cys Leu Lys Phe Tyr Ser Lys Ile 
65                  70                  75                  80  


Ser Glu Tyr Arg His Tyr Cys Tyr Ser Leu Tyr Gly Thr Thr Leu Glu 
                85                  90                  95      


Gln Gln Tyr Asn Lys Pro Leu Cys Asp Leu Leu Ile Arg Cys Ile Asn 
            100                 105                 110         


Cys Gln Lys Pro Leu Cys Pro Glu Glu Lys Gln Arg His Leu Asp Lys 
        115                 120                 125             


Lys Gln Arg Phe His Asn Ile Arg Gly Arg Trp Thr Gly Arg Cys Met 
    130                 135                 140                 


Ser Cys Cys Arg Ser Ser Arg Thr Arg Arg Glu Thr Gln Leu 
145                 150                 155             


<210>  93
<211>  505
<212>  PRT
<213>  Human papillomavirus 16

<400>  93

Met Ser Leu Trp Leu Pro Ser Glu Ala Thr Val Tyr Leu Pro Pro Val 
1               5                   10                  15      


Pro Val Ser Lys Val Val Ser Thr Asp Glu Tyr Val Ala Arg Thr Asn 
            20                  25                  30          


Ile Tyr Tyr His Ala Gly Thr Ser Arg Leu Leu Ala Val Gly His Pro 
        35                  40                  45              


Tyr Phe Pro Ile Lys Lys Pro Asn Asn Asn Lys Ile Leu Val Pro Lys 
    50                  55                  60                  


Val Ser Gly Leu Gln Tyr Arg Val Phe Arg Ile His Leu Pro Asp Pro 
65                  70                  75                  80  


Asn Lys Phe Gly Phe Pro Asp Thr Ser Phe Tyr Asn Pro Asp Thr Gln 
                85                  90                  95      


Arg Leu Val Trp Ala Cys Val Gly Val Glu Val Gly Arg Gly Gln Pro 
            100                 105                 110         


Leu Gly Val Gly Ile Ser Gly His Pro Leu Leu Asn Lys Leu Asp Asp 
        115                 120                 125             


Thr Glu Asn Ala Ser Ala Tyr Ala Ala Asn Ala Gly Val Asp Asn Arg 
    130                 135                 140                 


Glu Cys Ile Ser Met Asp Tyr Lys Gln Thr Gln Leu Cys Leu Ile Gly 
145                 150                 155                 160 


Cys Lys Pro Pro Ile Gly Glu His Trp Gly Lys Gly Ser Pro Cys Thr 
                165                 170                 175     


Asn Val Ala Val Asn Pro Gly Asp Cys Pro Pro Leu Glu Leu Ile Asn 
            180                 185                 190         


Thr Val Ile Gln Asp Gly Asp Met Val Asp Thr Gly Phe Gly Ala Met 
        195                 200                 205             


Asp Phe Thr Thr Leu Gln Ala Asn Lys Ser Glu Val Pro Leu Asp Ile 
    210                 215                 220                 


Cys Thr Ser Ile Cys Lys Tyr Pro Asp Tyr Ile Lys Met Val Ser Glu 
225                 230                 235                 240 


Pro Tyr Gly Asp Ser Leu Phe Phe Tyr Leu Arg Arg Glu Gln Met Phe 
                245                 250                 255     


Val Arg His Leu Phe Asn Arg Ala Gly Ala Val Gly Glu Asn Val Pro 
            260                 265                 270         


Asp Asp Leu Tyr Ile Lys Gly Ser Gly Ser Thr Ala Asn Leu Ala Ser 
        275                 280                 285             


Ser Asn Tyr Phe Pro Thr Pro Ser Gly Ser Met Val Thr Ser Asp Ala 
    290                 295                 300                 


Gln Ile Phe Asn Lys Pro Tyr Trp Leu Gln Arg Ala Gln Gly His Asn 
305                 310                 315                 320 


Asn Gly Ile Cys Trp Gly Asn Gln Leu Phe Val Thr Val Val Asp Thr 
                325                 330                 335     


Thr Arg Ser Thr Asn Met Ser Leu Cys Ala Ala Ile Ser Thr Ser Glu 
            340                 345                 350         


Thr Thr Tyr Lys Asn Thr Asn Phe Lys Glu Tyr Leu Arg His Gly Glu 
        355                 360                 365             


Glu Tyr Asp Leu Gln Phe Ile Phe Gln Leu Cys Lys Ile Thr Leu Thr 
    370                 375                 380                 


Ala Asp Val Met Thr Tyr Ile His Ser Met Asn Ser Thr Ile Leu Glu 
385                 390                 395                 400 


Asp Trp Asn Phe Gly Leu Gln Pro Pro Pro Gly Gly Thr Leu Glu Asp 
                405                 410                 415     


Thr Tyr Arg Phe Val Thr Ser Gln Ala Ile Ala Cys Gln Lys His Thr 
            420                 425                 430         


Pro Pro Ala Pro Lys Glu Asp Pro Leu Lys Lys Tyr Thr Phe Trp Glu 
        435                 440                 445             


Val Asn Leu Lys Glu Lys Phe Ser Ala Asp Leu Asp Gln Phe Pro Leu 
    450                 455                 460                 


Gly Arg Lys Phe Leu Leu Gln Ala Gly Leu Lys Ala Lys Pro Lys Phe 
465                 470                 475                 480 


Thr Leu Gly Lys Arg Lys Ala Thr Pro Thr Thr Ser Ser Thr Ser Thr 
                485                 490                 495     


Thr Ala Lys Arg Lys Lys Arg Lys Leu 
            500                 505 


<210>  94
<211>  649
<212>  PRT
<213>  Human papillomavirus 16

<400>  94

Met Ala Asp Pro Ala Gly Thr Asn Gly Glu Glu Gly Thr Gly Cys Asn 
1               5                   10                  15      


Gly Trp Phe Tyr Val Glu Ala Val Val Glu Lys Lys Thr Gly Asp Ala 
            20                  25                  30          


Ile Ser Asp Asp Glu Asn Glu Asn Asp Ser Asp Thr Gly Glu Asp Leu 
        35                  40                  45              


Val Asp Phe Ile Val Asn Asp Asn Asp Tyr Leu Thr Gln Ala Glu Thr 
    50                  55                  60                  


Glu Thr Ala His Ala Leu Phe Thr Ala Gln Glu Ala Lys Gln His Arg 
65                  70                  75                  80  


Asp Ala Val Gln Val Leu Lys Arg Lys Tyr Leu Val Ser Pro Leu Ser 
                85                  90                  95      


Asp Ile Ser Gly Cys Val Asp Asn Asn Ile Ser Pro Arg Leu Lys Ala 
            100                 105                 110         


Ile Cys Ile Glu Lys Gln Ser Arg Ala Ala Lys Arg Arg Leu Phe Glu 
        115                 120                 125             


Ser Glu Asp Ser Gly Tyr Gly Asn Thr Glu Val Glu Thr Gln Gln Met 
    130                 135                 140                 


Leu Gln Val Glu Gly Arg His Glu Thr Glu Thr Pro Cys Ser Gln Tyr 
145                 150                 155                 160 


Ser Gly Gly Ser Gly Gly Gly Cys Ser Gln Tyr Ser Ser Gly Ser Gly 
                165                 170                 175     


Gly Glu Gly Val Ser Glu Arg His Thr Ile Cys Gln Thr Pro Leu Thr 
            180                 185                 190         


Asn Ile Leu Asn Val Leu Lys Thr Ser Asn Ala Lys Ala Ala Met Leu 
        195                 200                 205             


Ala Lys Phe Lys Glu Leu Tyr Gly Val Ser Phe Ser Glu Leu Val Arg 
    210                 215                 220                 


Pro Phe Lys Ser Asn Lys Ser Thr Cys Cys Asp Trp Cys Ile Ala Ala 
225                 230                 235                 240 


Phe Gly Leu Thr Pro Ser Ile Ala Asp Ser Ile Lys Thr Leu Leu Gln 
                245                 250                 255     


Gln Tyr Cys Leu Tyr Leu His Ile Gln Ser Leu Ala Cys Ser Trp Gly 
            260                 265                 270         


Met Val Val Leu Leu Leu Val Arg Tyr Lys Cys Gly Lys Asn Arg Glu 
        275                 280                 285             


Thr Ile Glu Lys Leu Leu Ser Lys Leu Leu Cys Val Ser Pro Met Cys 
    290                 295                 300                 


Met Met Ile Glu Pro Pro Lys Leu Arg Ser Thr Ala Ala Ala Leu Tyr 
305                 310                 315                 320 


Trp Tyr Lys Thr Gly Ile Ser Asn Ile Ser Glu Val Tyr Gly Asp Thr 
                325                 330                 335     


Pro Glu Trp Ile Gln Arg Gln Thr Val Leu Gln His Ser Phe Asn Asp 
            340                 345                 350         


Cys Thr Phe Glu Leu Ser Gln Met Val Gln Trp Ala Tyr Asp Asn Asp 
        355                 360                 365             


Ile Val Asp Asp Ser Glu Ile Ala Tyr Lys Tyr Ala Gln Leu Ala Asp 
    370                 375                 380                 


Thr Asn Ser Asn Ala Ser Ala Phe Leu Lys Ser Asn Ser Gln Ala Lys 
385                 390                 395                 400 


Ile Val Lys Asp Cys Ala Thr Met Cys Arg His Tyr Lys Arg Ala Glu 
                405                 410                 415     


Lys Lys Gln Met Ser Met Ser Gln Trp Ile Lys Tyr Arg Cys Asp Arg 
            420                 425                 430         


Val Asp Asp Gly Gly Asp Trp Lys Gln Ile Val Met Phe Leu Arg Tyr 
        435                 440                 445             


Gln Gly Val Glu Phe Met Ser Phe Leu Thr Ala Leu Lys Arg Phe Leu 
    450                 455                 460                 


Gln Gly Ile Pro Lys Lys Asn Cys Ile Leu Leu Tyr Gly Ala Ala Asn 
465                 470                 475                 480 


Thr Gly Lys Ser Leu Phe Gly Met Ser Leu Met Lys Phe Leu Gln Gly 
                485                 490                 495     


Ser Val Ile Cys Phe Val Asn Ser Lys Ser His Phe Trp Leu Gln Pro 
            500                 505                 510         


Leu Ala Asp Ala Lys Ile Gly Met Leu Asp Asp Ala Thr Val Pro Cys 
        515                 520                 525             


Trp Asn Tyr Ile Asp Asp Asn Leu Arg Asn Ala Leu Asp Gly Asn Leu 
    530                 535                 540                 


Val Ser Met Asp Val Lys His Arg Pro Leu Val Gln Leu Lys Cys Pro 
545                 550                 555                 560 


Pro Leu Leu Ile Thr Ser Asn Ile Asn Ala Gly Thr Asp Ser Arg Trp 
                565                 570                 575     


Pro Tyr Leu His Asn Arg Leu Val Val Phe Thr Phe Pro Asn Glu Phe 
            580                 585                 590         


Pro Phe Asp Glu Asn Gly Asn Pro Val Tyr Glu Leu Asn Asp Lys Asn 
        595                 600                 605             


Trp Lys Ser Phe Phe Ser Arg Thr Trp Ser Arg Leu Ser Leu His Glu 
    610                 615                 620                 


Asp Glu Asp Lys Glu Asn Asp Gly Asp Ser Leu Pro Thr Phe Lys Cys 
625                 630                 635                 640 


Val Ser Gly Gln Asn Thr Asn Thr Leu 
                645                 


<210>  95
<211>  365
<212>  PRT
<213>  Human papillomavirus 16

<400>  95

Met Glu Thr Leu Cys Gln Arg Leu Asn Val Cys Gln Asp Lys Ile Leu 
1               5                   10                  15      


Thr His Tyr Glu Asn Asp Ser Thr Asp Leu Arg Asp His Ile Asp Tyr 
            20                  25                  30          


Trp Lys His Met Arg Leu Glu Cys Ala Ile Tyr Tyr Lys Ala Arg Glu 
        35                  40                  45              


Met Gly Phe Lys His Ile Asn His Gln Val Val Pro Thr Leu Ala Val 
    50                  55                  60                  


Ser Lys Asn Lys Ala Leu Gln Ala Ile Glu Leu Gln Leu Thr Leu Glu 
65                  70                  75                  80  


Thr Ile Tyr Asn Ser Gln Tyr Ser Asn Glu Lys Trp Thr Leu Gln Asp 
                85                  90                  95      


Val Ser Leu Glu Val Tyr Leu Thr Ala Pro Thr Gly Cys Ile Lys Lys 
            100                 105                 110         


His Gly Tyr Thr Val Glu Val Gln Phe Asp Gly Asp Ile Cys Asn Thr 
        115                 120                 125             


Met His Tyr Thr Asn Trp Thr His Ile Tyr Ile Cys Glu Glu Ala Ser 
    130                 135                 140                 


Val Thr Val Val Glu Gly Gln Val Asp Tyr Tyr Gly Leu Tyr Tyr Val 
145                 150                 155                 160 


His Glu Gly Ile Arg Thr Tyr Phe Val Gln Phe Lys Asp Asp Ala Glu 
                165                 170                 175     


Lys Tyr Ser Lys Asn Lys Val Trp Glu Val His Ala Gly Gly Gln Val 
            180                 185                 190         


Ile Leu Cys Pro Thr Ser Val Phe Ser Ser Asn Glu Val Ser Ser Pro 
        195                 200                 205             


Glu Ile Ile Arg Gln His Leu Ala Asn His Pro Ala Ala Thr His Thr 
    210                 215                 220                 


Lys Ala Val Ala Leu Gly Thr Glu Glu Thr Gln Thr Thr Ile Gln Arg 
225                 230                 235                 240 


Pro Arg Ser Glu Pro Asp Thr Gly Asn Pro Cys His Thr Thr Lys Leu 
                245                 250                 255     


Leu His Arg Asp Ser Val Asp Ser Ala Pro Ile Leu Thr Ala Phe Asn 
            260                 265                 270         


Ser Ser His Lys Gly Arg Ile Asn Cys Asn Ser Asn Thr Thr Pro Ile 
        275                 280                 285             


Val His Leu Lys Gly Asp Ala Asn Thr Leu Lys Cys Leu Arg Tyr Arg 
    290                 295                 300                 


Phe Lys Lys His Cys Thr Leu Tyr Thr Ala Val Ser Ser Thr Trp His 
305                 310                 315                 320 


Trp Thr Gly His Asn Val Lys His Lys Ser Ala Ile Val Thr Leu Thr 
                325                 330                 335     


Tyr Asp Ser Glu Trp Gln Arg Asp Gln Phe Leu Ser Gln Val Lys Ile 
            340                 345                 350         


Pro Lys Thr Ile Thr Val Ser Thr Gly Phe Met Ser Ile 
        355                 360                 365 


<210>  96
<211>  278
<212>  PRT
<213>  Human coronavirus OC43

<400>  96

Met Ala Val Ala Tyr Ala Asp Lys Pro Asn His Phe Ile Asn Phe Pro 
1               5                   10                  15      


Leu Thr His Phe Gln Gly Phe Val Leu Asn Tyr Lys Gly Leu Gln Phe 
            20                  25                  30          


Gln Ile Leu Asp Glu Gly Val Asp Cys Lys Ile Gln Thr Ala Pro His 
        35                  40                  45              


Ile Ser Leu Thr Met Leu Asp Ile Gln Pro Glu Asp Tyr Lys Ser Val 
    50                  55                  60                  


Asp Val Ala Ile Gln Glu Val Ile Asp Asp Met His Trp Gly Asp Gly 
65                  70                  75                  80  


Phe Gln Ile Lys Phe Glu Asn Pro His Ile Leu Gly Arg Cys Ile Val 
                85                  90                  95      


Leu Asp Val Lys Gly Val Glu Glu Leu His Asp Asp Leu Val Asn Tyr 
            100                 105                 110         


Ile Arg Asp Lys Gly Cys Val Ala Asp Gln Ser Arg Lys Trp Ile Gly 
        115                 120                 125             


His Cys Thr Ile Ala Gln Leu Thr Asp Ala Ala Leu Ser Ile Lys Glu 
    130                 135                 140                 


Asn Val Asp Phe Ile Asn Ser Met Gln Phe Asn Tyr Lys Ile Thr Ile 
145                 150                 155                 160 


Asn Pro Ser Ser Pro Ala Arg Leu Glu Ile Val Lys Leu Gly Ala Glu 
                165                 170                 175     


Lys Lys Asp Gly Phe Tyr Glu Thr Ile Val Ser His Trp Met Gly Ile 
            180                 185                 190         


Arg Phe Glu Tyr Thr Ser Pro Thr Asp Lys Leu Ala Met Ile Met Gly 
        195                 200                 205             


Tyr Cys Cys Leu Asp Val Val Arg Lys Glu Leu Glu Glu Gly Asp Leu 
    210                 215                 220                 


Pro Glu Asn Asp Asp Asp Ala Trp Phe Lys Leu Ser Tyr His Tyr Glu 
225                 230                 235                 240 


Asn Asn Ser Trp Phe Phe Arg His Val Tyr Arg Lys Ser Phe His Phe 
                245                 250                 255     


Arg Lys Ala Cys Gln Asn Leu Asp Cys Asn Cys Leu Gly Phe Tyr Glu 
            260                 265                 270         


Ser Pro Val Glu Glu Asp 
        275             


<210>  97
<211>  440
<212>  PRT
<213>  Homo sapiens

<400>  97

Met Gly Ser Ser His Leu Leu Asn Lys Gly Leu Pro Leu Gly Val Arg 
1               5                   10                  15      


Pro Pro Ile Met Asn Gly Pro Leu His Pro Arg Pro Leu Val Ala Leu 
            20                  25                  30          


Leu Asp Gly Arg Asp Cys Thr Val Glu Met Pro Ile Leu Lys Asp Val 
        35                  40                  45              


Ala Thr Val Ala Phe Cys Asp Ala Gln Ser Thr Gln Glu Ile His Glu 
    50                  55                  60                  


Lys Val Leu Asn Glu Ala Val Gly Ala Leu Met Tyr His Thr Ile Thr 
65                  70                  75                  80  


Leu Thr Arg Glu Asp Leu Glu Lys Phe Lys Ala Leu Arg Ile Ile Val 
                85                  90                  95      


Arg Ile Gly Ser Gly Phe Asp Asn Ile Asp Ile Lys Ser Ala Gly Asp 
            100                 105                 110         


Leu Gly Ile Ala Val Cys Asn Val Pro Ala Ala Ser Val Glu Glu Thr 
        115                 120                 125             


Ala Asp Ser Thr Leu Cys His Ile Leu Asn Leu Tyr Arg Arg Ala Thr 
    130                 135                 140                 


Trp Leu His Gln Ala Leu Arg Glu Gly Thr Arg Val Gln Ser Val Glu 
145                 150                 155                 160 


Gln Ile Arg Glu Val Ala Ser Gly Ala Ala Arg Ile Arg Gly Glu Thr 
                165                 170                 175     


Leu Gly Ile Ile Gly Leu Gly Arg Val Gly Gln Ala Val Ala Leu Arg 
            180                 185                 190         


Ala Lys Ala Phe Gly Phe Asn Val Leu Phe Tyr Asp Pro Tyr Leu Ser 
        195                 200                 205             


Asp Gly Val Glu Arg Ala Leu Gly Leu Gln Arg Val Ser Thr Leu Gln 
    210                 215                 220                 


Asp Leu Leu Phe His Ser Asp Cys Val Thr Leu His Cys Gly Leu Asn 
225                 230                 235                 240 


Glu His Asn His His Leu Ile Asn Asp Phe Thr Val Lys Gln Met Arg 
                245                 250                 255     


Gln Gly Ala Phe Leu Val Asn Thr Ala Arg Gly Gly Leu Val Asp Glu 
            260                 265                 270         


Lys Ala Leu Ala Gln Ala Leu Lys Glu Gly Arg Ile Arg Gly Ala Ala 
        275                 280                 285             


Leu Asp Val His Glu Ser Glu Pro Phe Ser Phe Ser Gln Gly Pro Leu 
    290                 295                 300                 


Lys Asp Ala Pro Asn Leu Ile Cys Thr Pro His Ala Ala Trp Tyr Ser 
305                 310                 315                 320 


Glu Gln Ala Ser Ile Glu Met Arg Glu Glu Ala Ala Arg Glu Ile Arg 
                325                 330                 335     


Arg Ala Ile Thr Gly Arg Ile Pro Asp Ser Leu Lys Asn Cys Val Asn 
            340                 345                 350         


Lys Asp His Leu Thr Ala Ala Thr His Trp Ala Ser Met Asp Pro Ala 
        355                 360                 365             


Val Val His Pro Glu Leu Asn Gly Ala Ala Tyr Arg Tyr Pro Pro Gly 
    370                 375                 380                 


Val Val Gly Val Ala Pro Thr Gly Ile Pro Ala Ala Val Glu Gly Ile 
385                 390                 395                 400 


Val Pro Ser Ala Met Ser Leu Ser His Gly Leu Pro Pro Val Ala His 
                405                 410                 415     


Pro Pro His Ala Pro Ser Pro Gly Gln Thr Val Lys Pro Glu Ala Asp 
            420                 425                 430         


Arg Asp His Ala Ser Asp Gln Leu 
        435                 440 


<210>  98
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  98

Gly Leu Pro Thr Asp Thr Ile Arg Lys Glu Phe Arg Thr Arg Met 
1               5                   10                  15  


<210>  99
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  99

Leu Phe Gly Leu Gly Lys Asp Glu Gly Trp Gly Pro Pro Ala Arg 
1               5                   10                  15  


<210>  100
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  100

Thr Phe Asn Cys His His Ala Arg Pro Trp His Asn Gln Phe Val 
1               5                   10                  15  


<210>  101
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  101

Asn Leu Val Pro Met Val Ala Thr Val 
1               5                   


<210>  102
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  102

Thr Pro Arg Val Thr Gly Gly Gly Ala Met 
1               5                   10  


<210>  103
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  103

Phe Glu Gly Thr Glu Met Trp Asn Pro Asn Arg Glu Leu Ser Glu 
1               5                   10                  15  


<210>  104
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  104

Ala Ile Gly Ile Gly Ala Tyr Leu Val 
1               5                   


<210>  105
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  105

Ser Val Gln Gly Ile Ile Ile Tyr Arg 
1               5                   


<210>  106
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  106

Val Asp Gly Ile Gly Ile Leu Thr Ile 
1               5                   


<210>  107
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  107

Ser Ala Ser Val Gln Arg Ala Asp Thr Ser Leu 
1               5                   10      


<210>  108
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  108

Ala Thr Ile Ile Asp Ile Leu Thr Lys 
1               5                   


<210>  109
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  109

Ile Leu Glu Gly Ile Gly Ile Leu Ala Val 
1               5                   10  


<210>  110
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  110

Ile Leu Glu Gly Ile Gly Ile Leu Ser Val 
1               5                   10  


<210>  111
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  111

Met Asn Ala Ala Val Thr Phe Ala Asn Cys Ala Leu Gly Arg Val 
1               5                   10                  15  


<210>  112
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  112

Pro Trp Arg Lys Phe Pro Val Tyr Val Leu Gly Gln Phe Leu Gly 
1               5                   10                  15  


<210>  113
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  113

Ile Asn Cys Leu Ser Ser Pro Asn Glu Glu Thr Val Leu Ser Ala 
1               5                   10                  15  


<210>  114
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  114

Ser Thr Ala Tyr Pro Ala Pro Met Arg Arg Arg Cys Cys Leu Pro 
1               5                   10                  15  


<210>  115
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  115

Ile Leu Asp Glu Lys Pro Val Ile Ile 
1               5                   


<210>  116
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  116

Val Leu Asn Gly Thr Val His Pro Val 
1               5                   


<210>  117
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  117

Ala Leu Ile Gly Gly Pro Pro Val 
1               5               


<210>  118
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  118

His Ile Glu Asn Phe Ser Asp Ile Asp Met Gly Glu 
1               5                   10          


<210>  119
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  119

Val Ala Leu Lys Pro Gln Glu Arg Val Glu Lys Arg Gln Thr Pro 
1               5                   10                  15  


<210>  120
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  120

Thr Leu Gly Glu Phe Leu Lys Leu 
1               5               


<210>  121
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  121

Gln Leu Cys Pro Ile Cys Arg Ala Pro Val 
1               5                   10  


<210>  122
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  122

Ala Phe Leu Gly Glu Arg Val Thr Leu 
1               5                   


<210>  123
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  123

Phe Leu Gly Glu Arg Val Thr Leu Thr 
1               5                   


<210>  124
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  124

Lys Leu Gly Pro Gly Glu Glu Gln Val 
1               5                   


<210>  125
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  125

Arg Phe Ile Ala Gln Leu Leu Leu Leu 
1               5                   


<210>  126
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  126

Thr Leu Thr Ser Tyr Trp Arg Arg Val 
1               5                   


<210>  127
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  127

Phe Leu Leu Ala Met Thr Ser Leu Arg 
1               5                   


<210>  128
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  128

Arg Pro Lys Ser Asn Ile Val Leu Leu 
1               5                   


<210>  129
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  129

Arg Pro Lys Ser Asn Ile Val Leu 
1               5               


<210>  130
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  130

Gly Leu Cys Thr Leu Val Ala Met Leu 
1               5                   


<210>  131
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  131

Leu Leu Gly Ile Gly Ile Leu Val Leu 
1               5                   


<210>  132
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  132

Leu Leu Leu Gly Ile Gly Ile Leu Val Leu 
1               5                   10  


<210>  133
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  133

Val Gln Leu Arg Gly Arg Ala Gln Gly Gly Gly Ala Leu Arg Ala 
1               5                   10                  15  


<210>  134
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  134

His Val Tyr Asp Gly Lys Phe Leu Ala Arg 
1               5                   10  


<210>  135
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  135

Gly Leu Leu Ser Leu Glu Glu Glu Leu 
1               5                   


<210>  136
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  136

Ala Arg Arg Arg Arg Arg Ala Glu Lys Lys Ala Ala Asp Val Ala Arg 
1               5                   10                  15      


Arg Lys Gln Glu 
            20  


<210>  137
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  137

Arg Arg Arg Ala Glu Lys Lys Ala Ala Asp Val Ala 
1               5                   10          


<210>  138
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  138

Arg Ala Lys Phe Lys Gln Leu Leu 
1               5               


<210>  139
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  139

Ser Pro Thr Ser Ser Arg Thr Ser Ser Leu 
1               5                   10  


<210>  140
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  140

Ala Arg Ala Ala Ala Ala Ala Ala Phe Glu Ile Asp Pro Arg Ser 
1               5                   10                  15  


<210>  141
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  141

Leu Leu Ala Ala Leu Val Gln Asp Tyr Leu 
1               5                   10  


<210>  142
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  142

Cys Met Leu Gly Thr Tyr Thr Gln Asp Phe 
1               5                   10  


<210>  143
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  143

Phe Leu Ala Leu Ser Ile Leu Val Leu 
1               5                   


<210>  144
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  144

Gly Asn Leu Ser Thr Cys Met Leu Gly Thr Tyr Thr Gln Asp Phe 
1               5                   10                  15  


<210>  145
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  145

Met Gly Phe Gln Lys Phe Ser Pro Phe Leu Ala Leu Ser Ile Leu 
1               5                   10                  15  


<210>  146
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  146

Val Leu Leu Gln Ala Gly Ser Leu His Ala 
1               5                   10  


<210>  147
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  147

Ser Leu Leu Met Trp Ile Thr Gln Cys 
1               5                   


<210>  148
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  148

Trp Ile Thr Gln Cys Phe Leu Pro Val Phe Leu Ala Gln Pro Pro Ser 
1               5                   10                  15      


Gly Gln Arg Arg 
            20  


<210>  149
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  149

Gln Leu Ser Leu Leu Met Trp Ile Thr 
1               5                   


<210>  150
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  150

Ala Pro Arg Gly Pro His Gly Gly Ala Ala Ser Gly Leu 
1               5                   10              


<210>  151
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  151

Glu Phe Thr Val Ser Gly Asn Ile Leu 
1               5                   


<210>  152
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  152

Leu Pro Val Pro Gly Val Leu Leu Lys Glu Phe Thr Val Ser Gly Asn 
1               5                   10                  15      


Ile Leu Thr Ile 
            20  


<210>  153
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  153

Arg Gly Pro Glu Ser Arg Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe 
1               5                   10                  15      


Ala Thr Pro Met 
            20  


<210>  154
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  154

Arg Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe Ala Thr Pro Met Glu 
1               5                   10                  15      


Ala Glu Leu Ala 
            20  


<210>  155
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  155

Val Leu Leu Lys Glu Phe Thr Val Ser Gly Asn Ile Leu Thr Ile Arg 
1               5                   10                  15      


Leu Thr Ala Ala 
            20  


<210>  156
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  156

Asp Ile Ala Gly Ile Gly Leu Lys Thr Val 
1               5                   10  


<210>  157
<211>  9
<212>  PRT
<213>  Clostridium sp. E02

<400>  157

Gly Ala Gly Ile Gly Val Leu Thr Ala 
1               5                   


<210>  158
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  158

His Leu Ser Thr Ala Phe Ala Arg Val 
1               5                   


<210>  159
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  159

Leu Pro Ser Gln Ala Phe Glu Tyr Ile Leu Tyr Asn Lys Gly 
1               5                   10                  


<210>  160
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  160

Lys Pro Gly Val Ile Phe Leu Thr Lys Arg Ser Arg Gln Val 
1               5                   10                  


<210>  161
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  161

Lys Val Ser Ala Val Thr Leu Ala Tyr 
1               5                   


<210>  162
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  162

Lys Leu Met Ser Pro Lys Leu Tyr Val Trp 
1               5                   10  


<210>  163
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  163

Val Glu Gly Ser Gly Glu Leu Phe Arg Trp 
1               5                   10  


<210>  164
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  164

Ser Thr Ala Thr His Ser Pro Ala Thr Thr Ser His Gly Asn Ala 
1               5                   10                  15  


<210>  165
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  165

Val Thr Val His Pro Thr Ser Asn Ser Thr Ala Thr Ser Gln Gly 
1               5                   10                  15  


<210>  166
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  166

Ala Val Gly Ile Gly Ile Ala Val Val 
1               5                   


<210>  167
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  167

Tyr Gly Tyr Asp Asn Val Lys Glu Tyr 
1               5                   


<210>  168
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  168

Leu Gln Arg Glu Tyr Ala Ser Val Lys Glu Glu Asn Glu Arg Leu 
1               5                   10                  15  


<210>  169
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  169

Met Glu Val Ser Gly Cys Pro Thr Pro Ala Gly Gln Ser 
1               5                   10              


<210>  170
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  170

Arg Thr Ile Ala Pro Ile Ile Gly Arg 
1               5                   


<210>  171
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  171

Ser Thr Pro Pro Pro Gly Ala Thr Arg Val 
1               5                   10  


<210>  172
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  172

His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn Arg 
1               5                   10                  15      


Arg Pro Ile Leu Thr Ile Ile Thr Leu 
            20                  25  


<210>  173
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  173

His Gly Leu Ser His Ser Leu Arg Gln Ile Ser Ser Gln Leu Ser 
1               5                   10                  15  


<210>  174
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  174

Arg Phe Glu Glu Lys His Ala Tyr Phe 
1               5                   


<210>  175
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  175

Met Gln Leu Met Pro Phe Gly Cys Leu Leu 
1               5                   10  


<210>  176
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  176

Leu Ile Met Gln Leu Met Pro Phe Gly Cys Leu 
1               5                   10      


<210>  177
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  177

Tyr Pro Phe Lys Pro Pro Lys Val 
1               5               


<210>  178
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  178

Glu Thr Gly Pro Glu Ala Glu Arg Leu Glu Gln Leu Glu Ser Gly 
1               5                   10                  15  


<210>  179
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  179

Ala Val Met Arg Trp Gly Met Pro Pro 
1               5                   


<210>  180
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  180

Ile Leu Phe Ser Leu Gln Pro Gly Leu Leu Arg Asp Trp 
1               5                   10              


<210>  181
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  181

Met Phe Thr Leu Thr Gly Cys Arg Leu Val Glu Lys Thr 
1               5                   10              


<210>  182
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  182

Arg Leu Trp Gln Glu Leu Ser Asp 
1               5               


<210>  183
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  183

Ala Thr Ala Gly Ile Ile Gly Val Asn Arg 
1               5                   10  


<210>  184
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  184

Thr His Arg Pro Gly Gly Lys His Gly Arg Leu Ala Gly Gly Ser 
1               5                   10                  15  


<210>  185
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  185

Ser Ser Leu Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro 
1               5                   10                  15  


<210>  186
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  186

Glu Val Pro Met Cys Ser Asp Pro Glu Pro Arg Gln Glu Val Pro 
1               5                   10                  15  


<210>  187
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  187

Val Thr Thr Lys Lys Thr Pro Pro Ser Gln Pro Pro Gly Asn Val 
1               5                   10                  15  


<210>  188
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  188

Tyr Leu Asn Lys Glu Ile Glu Glu Ala 
1               5                   


<210>  189
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  189

Ala Arg Gly Gly Leu Val Asp Glu Lys Ala Leu Ala Gln Ala Leu Lys 
1               5                   10                  15      


Glu Gly Arg Ile Arg Gly Ala Ala Leu 
            20                  25  


<210>  190
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  190

Ala Leu Thr Pro Val Val Val Thr Leu 
1               5                   


<210>  191
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  191

Asp Phe Gly Phe Ala Arg Thr Leu Ala Ala Pro Gly Asp Ile 
1               5                   10                  


<210>  192
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  192

Ile Asn Phe Lys Ile Glu Arg Gly Gln Leu Leu Ala Val 
1               5                   10              


<210>  193
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  193

Gly Leu Gly Ile Gly Ala Leu Val Leu 
1               5                   


<210>  194
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  194

Gln Trp Ile Lys Tyr Phe Asp Lys Arg Arg Asp Tyr Leu Lys Phe 
1               5                   10                  15  


<210>  195
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  195

Phe Ser Ile Ser Gln Leu Gln Lys Asn His Asp Met Asn Asp Glu 
1               5                   10                  15  


<210>  196
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  196

Ala Val Lys Arg Leu Pro Leu Val Tyr Cys Asp Tyr His Gly His 
1               5                   10                  15  


<210>  197
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  197

Met Leu Leu Asp Lys Asn Ile Pro Ile 
1               5                   


<210>  198
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  198

Ile Ala Gly Pro Gly Thr Ile Thr Leu 
1               5                   


<210>  199
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  199

Ser Ser Ser Gly Leu His Pro Pro Lys 
1               5                   


<210>  200
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  200

Val Thr Glu His Asp Thr Leu Leu Tyr 
1               5                   


<210>  201
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  201

Ser Ser Ala Glu Pro Thr Glu His Gly Glu Arg Thr Pro Leu Ala 
1               5                   10                  15  


<210>  202
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  202

Lys Pro Arg Gln Ser Ser Pro Gln Leu 
1               5                   


<210>  203
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  203

Gly Leu Tyr Tyr Val His Glu Gly Ile Arg Thr Tyr Phe Val Gln 
1               5                   10                  15  


<210>  204
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  204

Tyr Leu Thr Ala Pro Thr Gly Cys Ile 
1               5                   


<210>  205
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  205

Asp Ser Ala Pro Ile Leu Thr Ala Phe 
1               5                   


<210>  206
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  206

Ile Leu Thr Ala Phe Asn Ser Ser His Lys 
1               5                   10  


<210>  207
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  207

Lys Ser Ala Ile Val Thr Leu Thr Tyr 
1               5                   


<210>  208
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  208

Leu Ala Val Ser Lys Asn Lys Ala Leu 
1               5                   


<210>  209
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  209

Leu Gln Asp Val Ser Leu Glu Val Tyr 
1               5                   


<210>  210
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  210

Leu Thr Ala Pro Thr Gly Cys Ile Lys Lys 
1               5                   10  


<210>  211
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  211

Asn Pro Cys His Thr Thr Lys Leu Leu 
1               5                   


<210>  212
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  212

Asn Thr Thr Pro Ile Val His Leu Lys 
1               5                   


<210>  213
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  213

Gln Val Ile Leu Cys Pro Thr Ser Val 
1               5                   


<210>  214
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  214

Arg Leu Glu Cys Ala Ile Tyr Tyr Lys 
1               5                   


<210>  215
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  215

Ser Pro Glu Ile Ile Arg Gln His Leu 
1               5                   


<210>  216
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  216

Thr Leu Lys Cys Leu Arg Tyr Arg Phe Lys 
1               5                   10  


<210>  217
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  217

Thr Leu Tyr Thr Ala Val Ser Ser Thr 
1               5                   


<210>  218
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  218

Val Val Glu Gly Gln Val Asp Tyr Tyr 
1               5                   


<210>  219
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  219

Tyr Arg Phe Lys Lys His Cys Thr Leu 
1               5                   


<210>  220
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  220

Tyr Tyr Val His Glu Gly Ile Arg Thr Tyr 
1               5                   10  


<210>  221
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  221

Ala Leu Gln Ala Ile Glu Leu Gln Leu 
1               5                   


<210>  222
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  222

Thr Leu Gln Asp Val Ser Leu Glu Val 
1               5                   


<210>  223
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  223

Tyr Ile Cys Glu Glu Ala Ser Val Thr Val 
1               5                   10  


<210>  224
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  224

Cys Gln Asp Lys Ile Leu Thr His Tyr Glu Asn Asp Ser Thr Asp 
1               5                   10                  15  


<210>  225
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  225

Glu Glu Ala Ser Val Thr Val Val Glu Gly Gln Val Asp Tyr Tyr 
1               5                   10                  15  


<210>  226
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  226

Gln Val Ile Leu Cys Pro Thr Ser Val Phe Ser Ser Asn Glu Val 
1               5                   10                  15  


<210>  227
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  227

Thr Glu Glu Thr Gln Thr Thr Ile Gln Arg Pro Arg Ser Glu Pro 
1               5                   10                  15  


<210>  228
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  228

Val Leu Phe Tyr Leu Gly Gln Tyr Ile 
1               5                   


<210>  229
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  229

Asp Glu Lys Gln Gln His Ile Val Tyr 
1               5                   


<210>  230
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  230

Asp Glu Val Tyr Gln Val Thr Val Tyr 
1               5                   


<210>  231
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  231

Pro Ser Arg His Arg Tyr Gly Ala Arg Gln Pro Arg Ala Arg Leu 
1               5                   10                  15  


<210>  232
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  232

Leu Gly Leu Trp Arg Gly Glu Glu Val Thr Leu Ser Asn Pro Lys 
1               5                   10                  15  


<210>  233
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  233

Leu Trp Thr Glu Gly Met Leu Gln Met Ala Phe His Ile Leu Ala 
1               5                   10                  15  


<210>  234
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  234

Leu Leu Ser Val Ser Thr Tyr Thr Ser Leu Ile Leu Leu Val Leu 
1               5                   10                  15  


<210>  235
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  235

Tyr Ile Ile Phe Val Tyr Ile Pro Leu 
1               5                   


<210>  236
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  236

Phe Ala Phe Arg Asp Leu Cys Ile Val 
1               5                   


<210>  237
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  237

Ile Ile Leu Glu Cys Val Tyr Cys Lys 
1               5                   


<210>  238
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  238

Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys 
1               5                   10  


<210>  239
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  239

Pro Tyr Ala Val Cys Asp Lys Cys Leu 
1               5                   


<210>  240
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  240

Thr Thr Leu Glu Gln Gln Tyr Asn Lys 
1               5                   


<210>  241
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  241

Val Cys Asp Lys Cys Leu Lys Phe Tyr 
1               5                   


<210>  242
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  242

Cys Pro Glu Glu Lys Gln Arg His Leu 
1               5                   


<210>  243
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  243

Gln Tyr Asn Lys Pro Leu Cys Asp Leu 
1               5                   


<210>  244
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  244

Phe Ala Phe Ser Asp Leu Cys Ile Val Tyr 
1               5                   10  


<210>  245
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  245

Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg His Tyr Cys Tyr 
1               5                   10                  15  


<210>  246
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  246

Ala Val Cys Asp Lys Cys Leu Lys Phe Tyr 
1               5                   10  


<210>  247
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  247

Cys Val Tyr Cys Lys Gln Gln Leu Leu Arg 
1               5                   10  


<210>  248
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  248

Asn Pro Tyr Ala Val Cys Asp Lys Cys Leu 
1               5                   10  


<210>  249
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  249

Arg Pro Arg Lys Leu Pro Gln Leu Cys Thr 
1               5                   10  


<210>  250
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  250

Tyr Ala Val Cys Asp Lys Cys Leu Lys Phe 
1               5                   10  


<210>  251
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  251

Tyr Gly Thr Thr Leu Glu Gln Gln Tyr 
1               5                   


<210>  252
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  252

Cys Tyr Ser Leu Tyr Gly Thr Thr Leu 
1               5                   


<210>  253
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  253

Phe Ala Phe Arg Asp Leu Cys Ile Val Tyr 
1               5                   10  


<210>  254
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  254

Glu Tyr Arg His Tyr Cys Tyr Ser Leu 
1               5                   


<210>  255
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  255

Pro Arg Lys Leu Pro Gln Leu Cys Thr Glu Leu Gln Thr Thr Ile 
1               5                   10                  15  


<210>  256
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  256

Gln Tyr Asn Lys Pro Leu Cys Asp Leu Leu 
1               5                   10  


<210>  257
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  257

Val Tyr Asp Phe Ala Phe Gln Asp Leu 
1               5                   


<210>  258
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  258

Phe Ala Cys Tyr Asp Leu Cys Ile Val Tyr 
1               5                   10  


<210>  259
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  259

Ile Leu Ile Arg Cys Ile Ile Cys Gln 
1               5                   


<210>  260
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  260

Lys Cys Leu Asn Glu Ile Leu Ile Arg 
1               5                   


<210>  261
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  261

Lys Val Cys Leu Arg Leu Leu Ser Lys 
1               5                   


<210>  262
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  262

Gly Ile Val Cys Pro Ile Cys Ser Gln Lys 
1               5                   10  


<210>  263
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  263

Ile Val Cys Pro Ile Cys Ser Gln Lys 
1               5                   


<210>  264
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  264

Gln Ala Glu Pro Asp Arg Ala His Tyr 
1               5                   


<210>  265
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  265

Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu Asp Leu Leu Met Gly 
1               5                   10                  15      


Thr Leu Gly Ile 
            20  


<210>  266
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  266

Arg Ala His Tyr Asn Ile Val Thr Phe 
1               5                   


<210>  267
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  267

Thr Leu Gly Ile Val Cys Pro Ile 
1               5               


<210>  268
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  268

Ala Gly Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe 
1               5                   10                  15      


Cys Cys Lys Cys Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His 
            20                  25                  30          


Val Asp Ile 
        35  


<210>  269
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  269

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


<210>  270
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  270

Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser Glu Glu Glu 
1               5                   10                  15      


Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp Arg Ala His 
            20                  25                  30          


Tyr Asn Ile Val 
        35      


<210>  271
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  271

Leu Phe Met Asp Ser Leu Asn Phe Val Cys Pro Trp Cys 
1               5                   10              


<210>  272
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  272

Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp Arg Ala His Tyr 
1               5                   10                  15      


Asn Ile 
        


<210>  273
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  273

Gly Val Asn His Gln His Leu Pro Ala Arg Arg Ala Glu Pro Gln 
1               5                   10                  15  


<210>  274
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  274

His Gly Asp Thr Pro Thr Leu His Glu Tyr 
1               5                   10  


<210>  275
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  275

His Tyr Asn Ile Val Thr Phe Cys Cys Lys 
1               5                   10  


<210>  276
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  276

Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile 
1               5                   10      


<210>  277
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  277

Met Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu 
1               5                   10                  15  


<210>  278
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  278

Thr Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr 
1               5                   10                  15  


<210>  279
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  279

Leu Gln Pro Glu Thr Thr Asp Leu Tyr 
1               5                   


<210>  280
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  280

Thr Pro Thr Leu His Glu Tyr Met Leu 
1               5                   


<210>  281
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  281

Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp 
1               5                   10                  15  


<210>  282
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  282

Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val Asp 
1               5                   10                  


<210>  283
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  283

Gly Thr Leu Gly Ile Val Cys Pro Ile 
1               5                   


<210>  284
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  284

His Val Asp Ile Arg Thr Leu Glu Asp 
1               5                   


<210>  285
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  285

Leu Leu Met Gly Thr Leu Gly Ile Val 
1               5                   


<210>  286
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  286

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met 
1               5                   10          


<210>  287
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  287

Thr Leu Gly Ile Val Cys Pro Ile Cys 
1               5                   


<210>  288
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  288

Thr Leu His Glu Tyr Met Leu Asp Leu 
1               5                   


<210>  289
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  289

Tyr Met Leu Asp Leu Gln Pro Glu Thr 
1               5                   


<210>  290
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  290

Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr 
1               5                   10  


<210>  291
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  291

Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln 
1               5                   10                  15      


Lys Pro 
        


<210>  292
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  292

His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr Leu Arg 
1               5                   10                  15      


Leu Cys Val Gln 
            20  


<210>  293
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  293

Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
1               5                   10                  15      


Asp Leu Leu Met 
            20  


<210>  294
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  294

Cys Cys Lys Cys Asp Ser Thr Leu 
1               5               


<210>  295
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  295

Ser Thr His Val Asp Ile Arg Thr Leu Glu Asp Leu Leu Met Gly 
1               5                   10                  15  


<210>  296
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  296

Cys Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile 
1               5                   10                  15      


Arg Thr Leu Glu 
            20  


<210>  297
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  297

Ala Thr Glu Val Arg Thr Leu Gln Gln 
1               5                   


<210>  298
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  298

Cys Thr Ile Val Cys Pro Ser Cys Ala 
1               5                   


<210>  299
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  299

Leu Cys Ile Asn Ser Thr Ala Thr Glu 
1               5                   


<210>  300
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  300

Cys Tyr Glu Gln Leu Gly Asp Ser Ser 
1               5                   


<210>  301
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  301

Ile Thr Ile Arg Cys Ile Ile Cys Gln 
1               5                   


<210>  302
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  302

Lys Thr Leu Glu Glu Arg Val Lys Lys 
1               5                   


<210>  303
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  303

Met Arg Gly Asp Lys Ala Thr Ile Lys 
1               5                   


<210>  304
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  304

Pro Tyr Gly Val Cys Ile Met Cys Leu 
1               5                   


<210>  305
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  305

Gln Leu Gly Asp Ser Ser Asp Glu Glu 
1               5                   


<210>  306
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  306

Arg Leu Gln Cys Val Gln Cys Lys Lys 
1               5                   


<210>  307
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  307

Val Tyr Lys Phe Leu Phe Thr Asp Leu 
1               5                   


<210>  308
<211>  15
<212>  PRT
<213>  Epstein-Barr virus

<400>  308

Gly Gly Ser Lys Thr Ser Leu Tyr Asn Leu Arg Arg Gly Thr Ala 
1               5                   10                  15  


<210>  309
<211>  11
<212>  PRT
<213>  Epstein-Barr virus

<400>  309

His Pro Val Gly Glu Ala Asp Tyr Phe Glu Tyr 
1               5                   10      


<210>  310
<211>  15
<212>  PRT
<213>  Epstein-Barr virus

<400>  310

Arg Pro Ser Cys Ile Gly Cys Lys Gly Thr His Gly Gly Thr Gly 
1               5                   10                  15  


<210>  311
<211>  26
<212>  PRT
<213>  Epstein-Barr virus

<400>  311

Asn Pro Lys Phe Glu Asn Ile Ala Glu Gly Leu Arg Ala Leu Leu Ala 
1               5                   10                  15      


Arg Ser His Val Glu Arg Thr Thr Asp Glu 
            20                  25      


<210>  312
<211>  15
<212>  PRT
<213>  Epstein-Barr virus

<400>  312

Pro Gly Thr Gly Pro Gly Asn Gly Leu Gly Glu Lys Gly Asp Thr 
1               5                   10                  15  


<210>  313
<211>  15
<212>  PRT
<213>  Epstein-Barr virus

<400>  313

Pro Pro Met Val Glu Gly Ala Ala Ala Glu Gly Asp Asp Gly Asp 
1               5                   10                  15  


<210>  314
<211>  9
<212>  PRT
<213>  Epstein-Barr virus

<400>  314

Val Leu Lys Asp Ala Ile Lys Asp Leu 
1               5                   


<210>  315
<211>  15
<212>  PRT
<213>  Epstein-Barr virus

<400>  315

Tyr Phe Met Val Phe Leu Gln Thr His Ile Phe Ala Glu Val Leu 
1               5                   10                  15  


<210>  316
<211>  9
<212>  PRT
<213>  Epstein-Barr virus

<400>  316

Arg Leu Arg Ala Glu Ala Gln Val Lys 
1               5                   


<210>  317
<211>  9
<212>  PRT
<213>  Epstein-Barr virus

<400>  317

Arg Pro Pro Ile Phe Ile Arg Arg Leu 
1               5                   


<210>  318
<211>  8
<212>  PRT
<213>  Epstein-Barr virus

<400>  318

Arg Tyr Ser Ile Phe Phe Asp Tyr 
1               5               


<210>  319
<211>  9
<212>  PRT
<213>  Epstein-Barr virus

<400>  319

Arg Tyr Ser Ile Phe Phe Asp Tyr Met 
1               5                   


<210>  320
<211>  9
<212>  PRT
<213>  Epstein-Barr virus

<400>  320

Val Gln Pro Pro Gln Leu Thr Gln Val 
1               5                   


<210>  321
<211>  9
<212>  PRT
<213>  Epstein-Barr virus

<400>  321

Val Ser Phe Ile Glu Phe Val Gly Trp 
1               5                   


<210>  322
<211>  9
<212>  PRT
<213>  Epstein-Barr virus

<400>  322

Arg Arg Ile Tyr Asp Leu Ile Glu Leu 
1               5                   


<210>  323
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  323

Val Ala Gly Cys Tyr Leu Lys Tyr Lys Lys Lys Asn Ser Leu Ser 
1               5                   10                  15  


<210>  324
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  324

Asp Pro Lys Asp Ala Glu Lys Ala Ile 
1               5                   


<210>  325
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  325

Gly Pro Phe Gly Ala Val Asn Asn Val 
1               5                   


<210>  326
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  326

Lys Pro Ser Gly Ala Thr Glu Pro Ile 
1               5                   


<210>  327
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  327

Pro Pro Ser Ala Cys Ser Pro Arg Phe 
1               5                   


<210>  328
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  328

Ser Pro Arg Phe Ser Pro Ile Thr Ile 
1               5                   


<210>  329
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  329

Leu Ala Asp Gly Glu Gly Gly Gly Thr Asp Glu Gly Ile Tyr Asp 
1               5                   10                  15  


<210>  330
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  330

Tyr Val Val Pro Pro Pro Ala Arg Pro Cys Pro Thr Ser Gly Pro 
1               5                   10                  15  


<210>  331
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  331

Val Leu Ala Cys Gly Leu Ser Arg Ile Trp Gly Glu Glu Arg Gly 
1               5                   10                  15  


<210>  332
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  332

Leu Asp His Ile Leu Glu Pro Ser Ile Pro Trp Lys Ser Lys 
1               5                   10                  


<210>  333
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  333

Phe Thr Gln Glu Val Ser Arg Leu Asn Ile Asn Leu His Phe Ser Lys 
1               5                   10                  15      


Cys Gly Phe Pro Phe 
            20      


<210>  334
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  334

Gly Gly Tyr Tyr Ser Ala Ser Tyr Ser Asp Pro Cys Ser Leu Lys Cys 
1               5                   10                  15      


Pro Tyr Leu Gly Cys 
            20      


<210>  335
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  335

His Ile Leu Glu Pro Ser Ile Pro Trp Lys Ser Lys Leu Leu Thr 
1               5                   10                  15  


<210>  336
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  336

Leu Pro Phe Asn Trp Thr His Cys Phe Asp Pro Gln Ile Gln Ala Ile 
1               5                   10                  15      


Val Ser Ser Pro Cys 
            20      


<210>  337
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  337

Ser Asn Leu Asp His Ile Leu Glu Pro Ser Ile Pro Trp Lys 
1               5                   10                  


<210>  338
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  338

Ser Gln Leu Pro Pro Thr Ala Pro Pro Leu Leu Pro His Ser Asn Leu 
1               5                   10                  15      


Asp His Ile Leu Glu Pro Ser Ile Pro Trp Lys Ser Lys Leu 
            20                  25                  30  


<210>  339
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  339

Gly Ala Gly Ile Gly Val Ala Val Leu 
1               5                   


<210>  340
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  340

Ile Ala Gly Ile Gly Ile Leu Ala Ile 
1               5                   


<210>  341
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  341

Gly Ile Gly Ile Gly Ser Gly Gln Leu 
1               5                   


<210>  342
<211>  20
<212>  PRT
<213>  Epstein-Barr virus

<400>  342

Val Phe Leu Gln Thr His Ile Phe Ala Glu Val Leu Lys Asp Ala Ile 
1               5                   10                  15      


Lys Asp Leu Val 
            20  


<210>  343
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  343

Glu Leu Phe Gln Asp Leu Ser Gln Leu 
1               5                   


<210>  344
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  344

Ile Gly Gly Ile Gly Thr Val Pro Val 
1               5                   


<210>  345
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  345

Thr Met Leu Ala Arg Leu Val Ser Asp Ser 
1               5                   10  


<210>  346
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  346

Gly Thr Ser Ser Val Ile Val Ser Arg 
1               5                   


<210>  347
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  347

Arg Ile Asn Glu Phe Ser Ile Ser Ser Phe 
1               5                   10  


<210>  348
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  348

Asp Glu Val Ser Met Lys Gly Arg Pro Pro Pro Thr Pro Leu Phe 
1               5                   10                  15  


<210>  349
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  349

Tyr Leu Cys Ser Gly Ser Ser Tyr Phe 
1               5                   


<210>  350
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  350

Tyr Leu Cys Ser Gly Ser Ser Tyr Phe Val 
1               5                   10  


<210>  351
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  351

Ala Leu Gly Ile Gly Ala Val Pro Ile 
1               5                   


<210>  352
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  352

Ser Gln Asn Pro Arg Phe Tyr His Lys 
1               5                   


<210>  353
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  353

Ala Leu Phe Asp Ile Glu Ser Lys Val 
1               5                   


<210>  354
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  354

Met Gln Leu Ile Pro Asp Asp Tyr Ser Asn Thr His Ser Thr Arg Tyr 
1               5                   10                  15      


Val Thr Val Lys 
            20  


<210>  355
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  355

Glu Tyr Ile Leu Ser Leu Glu Glu Leu 
1               5                   


<210>  356
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  356

Phe Val Gly Glu Phe Phe Thr Asp Val 
1               5                   


<210>  357
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  357

Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys 
1               5                   10      


<210>  358
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  358

Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys Ser Ala Leu 
1               5                   10                  15  


<210>  359
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  359

Val Tyr Leu Asp Lys Phe Ile Arg Leu 
1               5                   


<210>  360
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  360

Phe Lys Gln Asp Leu Met Ile Glu Asp Asn Leu Leu 
1               5                   10          


<210>  361
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  361

Ala Leu Lys Ile Lys Gly Ile His Pro Tyr His Ser Leu Ser Tyr 
1               5                   10                  15  


<210>  362
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  362

Thr Pro Glu Pro Ala Ile Pro Pro Lys Ala Thr Leu Trp Pro Ala 
1               5                   10                  15  


<210>  363
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  363

Leu Leu Asp Val Ala Pro Leu Ser Leu 
1               5                   


<210>  364
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  364

Leu Leu Leu Leu Asp Val Ala Pro Leu 
1               5                   


<210>  365
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  365

Thr Tyr Leu Pro Thr Asn Ala Ser Leu 
1               5                   


<210>  366
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  366

Val Leu His Asp Asp Leu Leu Glu Ala 
1               5                   


<210>  367
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  367

Leu Glu Lys Gln Leu Ile Glu Leu 
1               5               


<210>  368
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  368

Ser Val Ser Pro Val Val His Val Arg 
1               5                   


<210>  369
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  369

Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro 
1               5                   10                  15      


Cys Lys Cys Pro 
            20  


<210>  370
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  370

Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
1               5                   10                  


<210>  371
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  371

Leu Gly Ile Gly Val Ile Thr Ile 
1               5               


<210>  372
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  372

Gly Tyr Gly Glu Met Gly Ser Gly Tyr Arg Glu Asp Leu Gly Ala 
1               5                   10                  15  


<210>  373
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  373

Glu Thr Asp Pro Leu Thr Phe Asn Phe 
1               5                   


<210>  374
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  374

Leu Gln Pro Tyr Tyr Gly Phe Ser Asn Gln Glu Val Ile Glu Met Val 
1               5                   10                  15      


Arg Lys Arg Gln 
            20  


<210>  375
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  375

Asn Lys Ser Gln Lys Pro Tyr Lys Ile 
1               5                   


<210>  376
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  376

Ser Leu Ser Ala Ser Pro Val Ser Asn 
1               5                   


<210>  377
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  377

Thr Met Ile Gly Thr Ser Ser His Leu 
1               5                   


<210>  378
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  378

Val Ala Thr Asn Gly Lys Glu Val Val 
1               5                   


<210>  379
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  379

Asn Leu Ser Ala Leu Gly Ile Phe Ser Thr 
1               5                   10  


<210>  380
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  380

Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr Ser 
1               5                   10                  15  


<210>  381
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  381

Tyr Lys Ala Phe Ser Ser Leu Leu Ala Ser Ser Ala Val Ser Pro Glu 
1               5                   10                  15      


<210>  382
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  382

Leu Ile Gly Ile Gly Ile Ala Pro Leu 
1               5                   


<210>  383
<211>  9
<212>  PRT
<213>  Human herpesvirus 8

<400>  383

Leu Val Leu Ile Leu Tyr Leu Cys Val 
1               5                   


<210>  384
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  384

Leu Leu Asp Arg Gly Ser Phe Arg Asn Asp Gly Leu Lys Ala Ser 
1               5                   10                  15  


<210>  385
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  385

Ala Arg Val Ile Leu Gly Val Arg Trp Tyr Val Glu Thr Thr Ser 
1               5                   10                  15  


<210>  386
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  386

Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Gly Asp His Leu 
1               5                   10                  15  


<210>  387
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  387

Lys Pro Val Ile Leu Gly Val Arg Trp Tyr Val Glu Thr Thr Ser 
1               5                   10                  15  


<210>  388
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  388

Ser Gln Leu Met Leu Thr Arg Lys Ala Glu Ala Ala Leu Arg Lys 
1               5                   10                  15  


<210>  389
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  389

Val Pro Val Ala Gln Val Thr Thr Thr Ser Thr Thr Asp Ala Asp 
1               5                   10                  15  


<210>  390
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  390

Cys Arg Pro Gln Cys Cys Gln Ser Val Cys Cys Gln Pro Thr Cys 
1               5                   10                  15  


<210>  391
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  391

Pro Arg Cys Cys Ile Ser Ser Cys Cys Arg Pro Ser Cys Cys Val 
1               5                   10                  15  


<210>  392
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  392

Ser Ser Gly Gly Gly Ser Ser Gly Gly Gly Tyr Gly Gly Gly Ser 
1               5                   10                  15  


<210>  393
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  393

Thr Cys Cys Arg Thr Thr Cys Tyr Arg Pro Ser Cys Cys Val Ser 
1               5                   10                  15  


<210>  394
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  394

Ala Phe Thr Leu Leu Leu Tyr Cys Glu Leu Leu Gln Trp Glu Asp 
1               5                   10                  15  


<210>  395
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  395

Glu Asn Lys Asn Gln Glu Leu Arg Ser Leu Ile Ser Gln Tyr Gln 
1               5                   10                  15  


<210>  396
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  396

Asn Val Ser Phe Phe His Tyr Pro Glu Tyr Gly Tyr 
1               5                   10          


<210>  397
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  397

Arg Lys Phe Ile Ser Leu His Arg Lys Ala Leu Glu Ser Asp Phe 
1               5                   10                  15  


<210>  398
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  398

Leu Gln Ile Glu Glu Glu Tyr Gln Val 
1               5                   


<210>  399
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  399

Ile His Ser Met Asn Ser Ser Ile Leu 
1               5                   


<210>  400
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  400

Asn Val Phe Pro Ile Phe Leu Gln Met 
1               5                   


<210>  401
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  401

Ala Val Pro Asp Asp Leu Tyr Ile Lys 
1               5                   


<210>  402
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  402

Lys Tyr Thr Phe Trp Glu Val Asn Leu 
1               5                   


<210>  403
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  403

Ile His Ser Met Asn Ser Thr Ile Leu 
1               5                   


<210>  404
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  404

Asn Leu Ala Ser Ser Asn Tyr Phe Pro Thr Pro Ser Gly Ser Met 
1               5                   10                  15  


<210>  405
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  405

Pro Ser Gly Ser Met Val Thr Ser Asp Ala Gln Ile Phe Asn Lys 
1               5                   10                  15  


<210>  406
<211>  20
<212>  PRT
<213>  Merkel cell polyomavirus

<400>  406

Gly Asn Ile Pro Leu Met Lys Ala Ala Phe Lys Arg Ser Cys Leu Lys 
1               5                   10                  15      


His His Pro Asp 
            20  


<210>  407
<211>  13
<212>  PRT
<213>  Merkel cell polyomavirus

<400>  407

Met Asp Leu Val Leu Asn Arg Lys Glu Arg Glu Ala Leu 
1               5                   10              


<210>  408
<211>  20
<212>  PRT
<213>  Merkel cell polyomavirus

<400>  408

Asn Ser Gly Arg Glu Ser Ser Thr Pro Asn Gly Thr Ser Val Pro Arg 
1               5                   10                  15      


Asn Ser Ser Arg 
            20  


<210>  409
<211>  13
<212>  PRT
<213>  Merkel cell polyomavirus

<400>  409

Pro Val Ile Met Met Glu Leu Asn Thr Leu Trp Ser Lys 
1               5                   10              


<210>  410
<211>  13
<212>  PRT
<213>  Merkel cell polyomavirus

<400>  410

Thr Leu Trp Ser Lys Phe Gln Gln Asn Ile His Lys Leu 
1               5                   10              


<210>  411
<211>  13
<212>  PRT
<213>  Merkel cell polyomavirus

<400>  411

Trp Glu Asp Leu Phe Cys Asp Glu Ser Leu Ser Ser Pro 
1               5                   10              


<210>  412
<211>  20
<212>  PRT
<213>  Merkel cell polyomavirus

<400>  412

Trp Glu Asp Leu Phe Cys Asp Glu Ser Leu Ser Ser Pro Glu Pro Pro 
1               5                   10                  15      


Ser Ser Ser Glu 
            20  


<210>  413
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  413

Thr Ser Glu Ser Gln Leu Phe Asn Lys 
1               5                   


<210>  414
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  414

Tyr Tyr Tyr Ala Gly Ser Ser Arg Leu 
1               5                   


<210>  415
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  415

Leu Gln Phe Ile Phe Gln Leu Cys Lys 
1               5                   


<210>  416
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  416

Met Thr Leu Cys Ala Glu Val Lys Lys 
1               5                   


<210>  417
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  417

Gln Tyr Arg Val Phe Arg Ile Lys Leu 
1               5                   


<210>  418
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  418

Tyr Leu Leu Glu Met Leu Trp Arg Leu 
1               5                   


<210>  419
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  419

Tyr Leu Gln Gln Asn Trp Trp Thr Leu 
1               5                   


<210>  420
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  420

Ala Leu Leu Val Leu Tyr Ser Phe Ala 
1               5                   


<210>  421
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  421

Cys Leu Gly Gly Leu Leu Thr Met Val 
1               5                   


<210>  422
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  422

Gly Leu Gly Thr Leu Gly Ala Ala Leu 
1               5                   


<210>  423
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  423

Leu Leu Ser Ala Trp Ile Leu Thr Ala 
1               5                   


<210>  424
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  424

Leu Leu Trp Thr Leu Val Val Leu Leu 
1               5                   


<210>  425
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  425

Pro Tyr Leu Phe Trp Leu Ala Ala Ile 
1               5                   


<210>  426
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  426

Met Gly Ser Leu Glu Met Val Pro Met 
1               5                   


<210>  427
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  427

Ser Leu Gly Gly Leu Leu Thr Met Ala 
1               5                   


<210>  428
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  428

Thr Tyr Gly Pro Val Phe Met Ser Leu 
1               5                   


<210>  429
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  429

Ser Ser Cys Ser Ser Cys Pro Leu Ser Lys Val 
1               5                   10      


<210>  430
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  430

Gln Lys Glu Lys Ser Leu Glu Phe Thr Lys Glu Leu Pro Gly Tyr 
1               5                   10                  15  


<210>  431
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  431

Pro Gly Glu Ser Leu Arg Pro Arg Gly Glu Arg Arg Leu Pro Gln 
1               5                   10                  15  


<210>  432
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  432

Pro Gly Ser Gly Pro Gln Asn Arg Leu Gly Arg Tyr Leu Glu Val 
1               5                   10                  15  


<210>  433
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  433

Ser Ser Phe Gly Arg Gly Phe Phe Lys 
1               5                   


<210>  434
<211>  20
<212>  PRT
<213>  Epstein-Barr virus

<400>  434

Ala Phe Phe Leu Asp Leu Ile Leu Leu Ile Ile Ala Leu Tyr Leu Gln 
1               5                   10                  15      


Gln Asn Trp Trp 
            20  


<210>  435
<211>  20
<212>  PRT
<213>  Epstein-Barr virus

<400>  435

Ala Leu Leu Val Leu Tyr Ser Phe Ala Leu Met Leu Ile Ile Ile Ile 
1               5                   10                  15      


Leu Ile Ile Phe 
            20  


<210>  436
<211>  20
<212>  PRT
<213>  Epstein-Barr virus

<400>  436

Cys Leu Leu Val Leu Gly Ile Trp Ile Tyr Leu Leu Glu Met Leu Trp 
1               5                   10                  15      


Arg Leu Gly Ala 
            20  


<210>  437
<211>  20
<212>  PRT
<213>  Epstein-Barr virus

<400>  437

Asp Trp Thr Gly Gly Ala Leu Leu Val Leu Tyr Ser Phe Ala Leu Met 
1               5                   10                  15      


Leu Ile Ile Ile 
            20  


<210>  438
<211>  20
<212>  PRT
<213>  Epstein-Barr virus

<400>  438

Gly Ala Leu Cys Ile Leu Leu Leu Met Ile Thr Leu Leu Leu Ile Ala 
1               5                   10                  15      


Leu Trp Asn Leu 
            20  


<210>  439
<211>  20
<212>  PRT
<213>  Epstein-Barr virus

<400>  439

Gly Ile Trp Ile Tyr Leu Leu Glu Met Leu Trp Arg Leu Gly Ala Thr 
1               5                   10                  15      


Ile Trp Gln Leu 
            20  


<210>  440
<211>  20
<212>  PRT
<213>  Epstein-Barr virus

<400>  440

Gly Pro Arg Arg Pro Pro Arg Gly Pro Pro Leu Ser Ser Ser Leu Gly 
1               5                   10                  15      


Leu Ala Leu Leu 
            20  


<210>  441
<211>  20
<212>  PRT
<213>  Epstein-Barr virus

<400>  441

Ile Leu Ile Ile Phe Ile Phe Arg Arg Asp Leu Leu Cys Pro Leu Gly 
1               5                   10                  15      


Ala Leu Cys Ile 
            20  


<210>  442
<211>  20
<212>  PRT
<213>  Epstein-Barr virus

<400>  442

Leu Phe Leu Ala Ile Leu Ile Trp Met Tyr Tyr His Gly Gln Arg His 
1               5                   10                  15      


Ser Asp Glu His 
            20  


<210>  443
<211>  20
<212>  PRT
<213>  Epstein-Barr virus

<400>  443

Leu Ile Leu Leu Ile Ile Ala Leu Tyr Leu Gln Gln Asn Trp Trp Thr 
1               5                   10                  15      


Leu Leu Val Asp 
            20  


<210>  444
<211>  20
<212>  PRT
<213>  Epstein-Barr virus

<400>  444

Leu Leu Phe Trp Leu Tyr Ile Val Met Ser Asp Trp Thr Gly Gly Ala 
1               5                   10                  15      


Leu Leu Val Leu 
            20  


<210>  445
<211>  20
<212>  PRT
<213>  Epstein-Barr virus

<400>  445

Leu Leu Leu Met Ile Thr Leu Leu Leu Ile Ala Leu Trp Asn Leu His 
1               5                   10                  15      


Gly Gln Ala Leu 
            20  


<210>  446
<211>  20
<212>  PRT
<213>  Epstein-Barr virus

<400>  446

Leu Leu Trp Leu Leu Leu Phe Leu Ala Ile Leu Ile Trp Met Tyr Tyr 
1               5                   10                  15      


His Gly Gln Arg 
            20  


<210>  447
<211>  20
<212>  PRT
<213>  Epstein-Barr virus

<400>  447

Leu Ser Ser Ser Leu Gly Leu Ala Leu Leu Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Leu Phe Trp Leu 
            20  


<210>  448
<211>  20
<212>  PRT
<213>  Epstein-Barr virus

<400>  448

Asn Asp Gly Gly Pro Pro Gln Leu Thr Glu Glu Val Glu Asn Lys Gly 
1               5                   10                  15      


Gly Asp Gln Gly 
            20  


<210>  449
<211>  20
<212>  PRT
<213>  Epstein-Barr virus

<400>  449

Pro Arg Gly Pro Pro Leu Ser Ser Ser Leu Gly Leu Ala Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Ala 
            20  


<210>  450
<211>  20
<212>  PRT
<213>  Epstein-Barr virus

<400>  450

Gln Gln Asn Trp Trp Thr Leu Leu Val Asp Leu Leu Trp Leu Leu Leu 
1               5                   10                  15      


Phe Leu Ala Ile 
            20  


<210>  451
<211>  20
<212>  PRT
<213>  Epstein-Barr virus

<400>  451

Tyr His Gly Gln Arg His Ser Asp Glu His His His Asp Asp Ser Leu 
1               5                   10                  15      


Pro His Pro Gln 
            20  


<210>  452
<211>  20
<212>  PRT
<213>  Epstein-Barr virus

<400>  452

Tyr Ile Val Met Ser Asp Trp Thr Gly Gly Ala Leu Leu Val Leu Tyr 
1               5                   10                  15      


Ser Phe Ala Leu 
            20  


<210>  453
<211>  20
<212>  PRT
<213>  Epstein-Barr virus

<400>  453

Tyr Ser Phe Ala Leu Met Leu Ile Ile Ile Ile Leu Ile Ile Phe Ile 
1               5                   10                  15      


Phe Arg Arg Asp 
            20  


<210>  454
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  454

Pro Ser His Gln Pro Pro Ala Ser Thr Leu Ser Pro Asn Pro Thr 
1               5                   10                  15  


<210>  455
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  455

Arg Tyr Cys Asn Leu Glu Gly Pro Pro Ile 
1               5                   10  


<210>  456
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  456

Tyr Met Ala Ser Trp Val Met Leu Gly Ile Thr Tyr Arg Asn Lys Ser 
1               5                   10                  15      


Leu Met Trp 
            


<210>  457
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  457

Ser Pro Arg Pro Pro Leu Gly Ser Ser Leu 
1               5                   10  


<210>  458
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  458

Asp Glu Met Asp Cys Pro Leu Ser Pro Thr Pro Pro Leu Cys Ser 
1               5                   10                  15  


<210>  459
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  459

Phe Leu Asn Gln Thr Asp Glu Thr Leu 
1               5                   


<210>  460
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  460

Lys Leu Leu Met Val Leu Met Leu Ala 
1               5                   


<210>  461
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  461

Leu Ile Tyr Asp Ser Ser Leu Cys Asp Leu 
1               5                   10  


<210>  462
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  462

Leu Met Val Leu Met Leu Ala Ala Leu 
1               5                   


<210>  463
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  463

Thr Ile Asn Pro Gln Val Ser Lys Thr 
1               5                   


<210>  464
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  464

Leu Trp His Leu Gln Gly Pro Lys Asp Leu Met Leu Lys Leu Arg 
1               5                   10                  15  


<210>  465
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  465

Tyr Leu Glu Lys Glu Ser Ile Tyr Tyr 
1               5                   


<210>  466
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  466

Gly Ile Leu Gly Phe Val Phe Thr Leu 
1               5                   


<210>  467
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  467

Arg Leu Glu Asp Val Phe Ala Gly Lys 
1               5                   


<210>  468
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  468

Val Met Met His Gly Gly Pro Pro His Pro Gly Met Pro Met Ser 
1               5                   10                  15  


<210>  469
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  469

Ala Leu Leu Ala Val Gly Ala Thr Lys 
1               5                   


<210>  470
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  470

Ile Thr Asp Gln Val Pro Phe Ser Val 
1               5                   


<210>  471
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  471

Trp Asn Arg Gln Leu Tyr Pro Glu Trp Thr Glu Ala Gln Arg Leu Asp 
1               5                   10                  15      


<210>  472
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  472

Tyr Leu Glu Pro Gly Pro Val Thr Ala 
1               5                   


<210>  473
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  473

Asn Arg Gln Leu Tyr Pro Glu Trp Thr Glu Ala Gln Arg Leu Asp 
1               5                   10                  15  


<210>  474
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  474

Asn Arg Gln Leu Tyr Pro Glu Trp Thr Glu Ala Gln Arg 
1               5                   10              


<210>  475
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  475

Arg Thr Lys Ala Trp Asn Arg Gln Leu Tyr Pro Glu Trp Thr Glu Ala 
1               5                   10                  15      


Gln Arg 
        


<210>  476
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  476

Trp Asn Arg Gln Leu Tyr Pro Glu Trp Thr Glu Ala Gln Arg 
1               5                   10                  


<210>  477
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  477

Arg Tyr Gly Ser Phe Ser Val Thr Leu 
1               5                   


<210>  478
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  478

Ala Ser Ser Ile Met Ser Thr Glu Ser Ile Thr Gly Ser Leu Gly Pro 
1               5                   10                  15      


Leu Leu Asp Gly 
            20  


<210>  479
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  479

Glu Ser Ile Thr Gly Ser Leu Gly Pro Leu Leu 
1               5                   10      


<210>  480
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  480

His Arg Arg Gly Ser Arg Ser Tyr Val 
1               5                   


<210>  481
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  481

Ser Thr Glu Ser Ile Thr Gly Ser Leu Gly Pro Leu Leu Asp Gly Thr 
1               5                   10                  15      


Ala Thr Leu Arg 
            20  


<210>  482
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  482

Thr His Thr Met Glu Val Thr Val Tyr His Arg Arg Gly Ser Arg Ser 
1               5                   10                  15      


Tyr Val Pro Leu 
            20  


<210>  483
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  483

Val Leu Tyr Arg Tyr Gly Ser Phe Ser Val Thr Leu Asp Ile Val Gln 
1               5                   10                  15      


Gly Ile Glu Ser 
            20  


<210>  484
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  484

Val Pro Leu Asp Cys Val Leu Tyr Arg Tyr Gly Ser Phe Ser Val Thr 
1               5                   10                  15      


Leu Asp Ile Val 
            20  


<210>  485
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  485

Val Thr Val Tyr His Arg Arg Gly Ser Arg Ser Tyr Val Pro Leu Ala 
1               5                   10                  15      


His Ser Ser Ser 
            20  


<210>  486
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  486

Ala Met Leu Gly Thr His Thr Met Glu Val 
1               5                   10  


<210>  487
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  487

Ala Leu Tyr Val Asp Ser Leu Phe Phe Leu 
1               5                   10  


<210>  488
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  488

Ser Gln Leu Thr Thr Leu Ser Phe Tyr 
1               5                   


<210>  489
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  489

Ala Ala Gly Ile Gly Ile Leu Thr Val 
1               5                   


<210>  490
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  490

Glu Ala Ala Gly Ile Gly Ile Leu Thr Val 
1               5                   10  


<210>  491
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  491

Ile Leu Thr Val Ile Leu Gly Val Leu 
1               5                   


<210>  492
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  492

Arg Asn Gly Tyr Arg Ala Leu Met Asp Lys Ser Leu His Val Gly Thr 
1               5                   10                  15      


Gln Cys Ala Leu Thr Arg Arg 
            20              


<210>  493
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  493

Ala Pro Pro Ala Tyr Glu Lys Leu Ser Ala Glu Gln 
1               5                   10          


<210>  494
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  494

Ala Pro Pro Ala Tyr Glu Lys Leu Ser Ala Glu Gln Ser Pro Pro 
1               5                   10                  15  


<210>  495
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  495

Ala Pro Pro Ala Tyr Glu Lys Leu Ser Ala Glu Gln Ser Pro Pro 
1               5                   10                  15  


<210>  496
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  496

Ala Pro Pro Ala Tyr Glu Lys Leu Ser Ala Glu Gln Ser Pro Pro Pro 
1               5                   10                  15      


Tyr 
    


<210>  497
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  497

Asn Ala Pro Pro Ala Tyr Glu Lys Leu Ser Ala Glu 
1               5                   10          


<210>  498
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  498

Val Pro Asn Ala Pro Pro Ala Tyr Glu Lys Leu Ser Ala Glu Gln Ser 
1               5                   10                  15      


Pro Pro Pro Tyr 
            20  


<210>  499
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  499

Glu Glu Ala Ala Gly Ile Gly Ile Leu 
1               5                   


<210>  500
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  500

Gly His Gly His Ser Tyr Thr Thr Ala Glu Glu Ala Ala Gly Ile Gly 
1               5                   10                  15      


Ile Leu Thr Val 
            20  


<210>  501
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  501

Tyr Thr Thr Ala Glu Glu Ala Ala Gly Ile Gly Ile Leu Thr Val Ile 
1               5                   10                  15      


Leu Gly Val Leu 
            20  


<210>  502
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  502

Glu Ala Asp Pro Thr Gly His Ser Tyr 
1               5                   


<210>  503
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  503

Arg Val Arg Phe Phe Phe Pro Ser Leu 
1               5                   


<210>  504
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  504

Glu Val Asp Pro Ile Gly His Leu Tyr 
1               5                   


<210>  505
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  505

Phe Leu Trp Gly Pro Arg Ala Leu Val 
1               5                   


<210>  506
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  506

Met Glu Val Asp Pro Ile Gly His Leu Tyr 
1               5                   10  


<210>  507
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  507

Glu Val Asp Pro Ile Gly His Val Tyr 
1               5                   


<210>  508
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  508

Leu Leu Phe Gly Leu Ala Leu Ile Glu Val 
1               5                   10  


<210>  509
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  509

Cys Pro Leu Ser Lys Ile Leu Leu 
1               5               


<210>  510
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  510

Phe Leu Tyr Ala Leu Ala Leu Leu 
1               5               


<210>  511
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  511

Phe Leu Tyr Ala Leu Ala Leu Leu Leu 
1               5                   


<210>  512
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  512

Gly Gly Ser Ile Leu Gln Thr Asn Phe Lys Ser Leu Ser Ser Thr Glu 
1               5                   10                  15      


Phe 
    


<210>  513
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  513

Ile Glu Asp Pro Pro Phe Asn Ser Leu 
1               5                   


<210>  514
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  514

Leu Leu Trp Thr Leu Val Val Leu 
1               5               


<210>  515
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  515

Leu Thr Ala Gly Phe Leu Ile Phe Leu 
1               5                   


<210>  516
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  516

Pro Tyr Leu Phe Trp Leu Ala Ala 
1               5               


<210>  517
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  517

Arg Arg Arg Trp Arg Arg Leu Thr Val 
1               5                   


<210>  518
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  518

Ser Ser Cys Ser Ser Cys Pro Leu Ser Lys 
1               5                   10  


<210>  519
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  519

Ser Ser Cys Ser Ser Cys Pro Leu Ser Lys Ile 
1               5                   10      


<210>  520
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  520

Thr Tyr Gly Pro Val Phe Met Cys Leu 
1               5                   


<210>  521
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  521

Val Met Ser Asn Thr Leu Leu Ser Ala Trp 
1               5                   10  


<210>  522
<211>  9
<212>  PRT
<213>  Human gammaherpesvirus 4

<400>  522

Val Thr Leu Ala His Ala Gly Tyr Tyr 
1               5                   


<210>  523
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  523

Pro Phe Ser Pro Ser His Pro Ala Pro Pro Ser Asp Pro Ser His 
1               5                   10                  15  


<210>  524
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  524

Ala Leu Gly Ile Gly Val Tyr Pro Val 
1               5                   


<210>  525
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  525

Val Asn Thr Thr Thr Ser Pro Val Asn Thr Thr Thr Ser Pro Val 
1               5                   10                  15  


<210>  526
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  526

Arg Thr Asp Leu Val Lys Ser Glu Leu Leu His Ile Glu Ser Gln 
1               5                   10                  15  


<210>  527
<211>  9
<212>  PRT
<213>  bacterium JGI 053

<400>  527

Ala Leu Gly Leu Gly Leu Leu Pro Val 
1               5                   


<210>  528
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  528

Asp Ile Leu Glu Gln Ala Arg Ala Ala Val Asp Thr Tyr Cys Arg 
1               5                   10                  15  


<210>  529
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  529

His Ser Leu Arg Tyr Phe Arg Leu Gly Val Ser Asp Pro Ile Arg Gly 
1               5                   10                  15      


Val Pro Glu 
            


<210>  530
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  530

Lys Asp Gln Gly Pro Ile Val Pro Ala Pro Val Lys Gly Glu Gly 
1               5                   10                  15  


<210>  531
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  531

Val Lys Asp Gln Gly Pro Met Val Ser Ala Pro Val Lys Asp Gln 
1               5                   10                  15  


<210>  532
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  532

Arg Ala Ser His Pro Ile Val Gln Lys 
1               5                   


<210>  533
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  533

Leu Leu Ser Ala Val Leu Pro Ser Val 
1               5                   


<210>  534
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  534

Ala Gln Gly Trp Ser Thr Val Ala Arg Phe Gln Ile Thr Ala Thr 
1               5                   10                  15  


<210>  535
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  535

Asn Thr Val Phe Gly Ala Glu Arg Lys Lys Arg Leu Ser Ile Ile Gly 
1               5                   10                  15      


Pro Thr Ser Arg Asp Arg Ser Ser Pro 
            20                  25  


<210>  536
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  536

Met Ser Tyr Asp Tyr His Gln Asn Trp Gly Arg Asp Gly Gly 
1               5                   10                  


<210>  537
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  537

Leu Asn Lys Val Thr Ile Asp Ala Arg His Arg Leu Pro Leu 
1               5                   10                  


<210>  538
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  538

His Gly Asn Ser Ser Ile Ile Ala Asp Gln Ile Ala Leu Lys Leu Val 
1               5                   10                  15      


Gly Pro Glu 
            


<210>  539
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  539

Thr Thr Thr Ala Ser Thr Glu Gly Ser Glu Thr Thr Thr Ala Ser 
1               5                   10                  15  


<210>  540
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  540

Ser Thr Ala Pro Pro Val His Asn Val 
1               5                   


<210>  541
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  541

Leu Leu Leu Leu Thr Val Leu Thr Val 
1               5                   


<210>  542
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  542

Phe Ala Ser Pro Gly Asp Asp Gly Asp Gly Arg Ala Glu Gly Phe 
1               5                   10                  15  


<210>  543
<211>  9
<212>  PRT
<213>  Pseudomonas

<400>  543

Leu Ala Gly Ile Gly Leu Ile Ala Ala 
1               5                   


<210>  544
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  544

Leu Gly Gly Leu Gly Leu Phe Phe Ala 
1               5                   


<210>  545
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  545

Val Leu Gln Glu Leu Asn Val Thr Val 
1               5                   


<210>  546
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  546

Glu His Ser Gln Glu Thr Glu Ser Leu Arg Glu Ala Leu Leu Ser 
1               5                   10                  15  


<210>  547
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  547

Tyr Ile Gly Glu Val Leu Val Ser Val 
1               5                   


<210>  548
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  548

Phe Leu Ile Ile Ile Leu Asp His Leu 
1               5                   


<210>  549
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  549

Lys Leu Ser Val Ala Pro Ser Glu Val Leu Glu Glu Asp Gln Val 
1               5                   10                  15  


<210>  550
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  550

Asn Gln Leu Lys Glu Arg Ser Phe Ala Gln Leu Ile Ser Lys Asp 
1               5                   10                  15  


<210>  551
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  551

Tyr Val Ser Met Met Cys Asn Glu Gln Ala Tyr Ser Leu Ala Val 
1               5                   10                  15  


<210>  552
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  552

Phe Leu Lys Gly Ile Gly Trp Ile Pro Ile 
1               5                   10  


<210>  553
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  553

Leu Arg Pro Gln Leu Ala Glu Asn Lys Gln Gln Phe Arg Asn Leu 
1               5                   10                  15  


<210>  554
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  554

Glu Lys Lys Gln Gln Phe Arg Asn Leu Lys Glu Lys Cys Phe Leu 
1               5                   10                  15  


<210>  555
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  555

Lys Ala Leu Arg Leu Ser Ala Ser Ala Leu Phe 
1               5                   10      


<210>  556
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  556

Ala Phe Met Tyr Ala Lys Lys Glu Glu Trp Lys Lys Ala Glu Glu 
1               5                   10                  15  


<210>  557
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  557

Thr Met Leu Asp Ile Gln Pro Glu Asp 
1               5                   


<210>  558
<211>  15
<212>  PRT
<213>  Epstein-Barr virus

<400>  558

Gly Val Phe Val Tyr Gly Gly Ser Lys Thr Ser Leu Tyr Asn Leu 
1               5                   10                  15  


<210>  559
<211>  9
<212>  PRT
<213>  Epstein-Barr virus

<400>  559

Phe Leu Arg Gly Arg Ala Tyr Gly Leu 
1               5                   


<210>  560
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  560

Lys Leu Lys Lys Lys Gln Val Asn Val Phe Ala 
1               5                   10      


<210>  561
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  561

Ile Leu Arg Gly Ser Val Ala His Lys 
1               5                   


<210>  562
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  562

Val Tyr Gly Ile Arg Leu Glu His Phe 
1               5                   


<210>  563
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  563

Ser Leu Leu Met Trp Ile Thr Gln Cys Phe Leu Pro Val Phe 
1               5                   10                  


<210>  564
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  564

Tyr Leu Ala Met Pro Phe Ala Thr Pro Met Glu Ala Glu Leu Ala Arg 
1               5                   10                  15      


Arg Ser Leu Ala 
            20  


<210>  565
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  565

Leu Ala Met Pro Phe Ala Thr Pro Met 
1               5                   


<210>  566
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  566

Met Pro Phe Ala Thr Pro Met Glu Ala 
1               5                   


<210>  567
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  567

Met Pro Phe Ala Thr Pro Met Glu Ala Glu Leu 
1               5                   10      


<210>  568
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  568

Pro Phe Ala Thr Pro Met Glu Ala Glu Leu Ala Arg 
1               5                   10          


<210>  569
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  569

Gln Asp Ala Pro Pro Leu Pro Val Pro Gly Val Leu Leu Lys Glu Phe 
1               5                   10                  15      


Thr Val Ser Gly Asn Ile Leu Thr Ile Arg Leu Thr Ala Ala Asp His 
            20                  25                  30          


Arg 
    


<210>  570
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  570

Ile Leu Leu Ile His Cys Asp Ala His Leu His Thr Pro Met Tyr 
1               5                   10                  15  


<210>  571
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  571

Leu Leu Ile His Cys Asp Ala His Leu His Thr Pro Met Tyr Phe 
1               5                   10                  15  


<210>  572
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  572

Ala Cys Asp Pro His Ser Gly His Phe Val 
1               5                   10  


<210>  573
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  573

Leu Phe Met Asp Thr Leu Ser Phe Val Cys Pro Leu Cys 
1               5                   10              


<210>  574
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  574

Ile Gly Leu Ile Thr Val Leu Phe Leu 
1               5                   


<210>  575
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  575

Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala Cys Pro Gly Arg 
1               5                   10                  15  


<210>  576
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  576

Gly Leu Ala Pro Pro Gln His Leu Ile Arg Val 
1               5                   10      


<210>  577
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  577

Lys Thr Cys Pro Val Gln Leu Trp Val 
1               5                   


<210>  578
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  578

Leu Leu Gly Arg Asn Ser Phe Glu Val 
1               5                   


<210>  579
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  579

Arg Met Pro Glu Ala Ala Pro Pro Val 
1               5                   


<210>  580
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  580

Tyr Gln Gly Ser Tyr Gly Phe Arg Leu 
1               5                   


<210>  581
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  581

Tyr Leu Leu Pro Ala Ile Val His Ile 
1               5                   


<210>  582
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  582

Gln Leu Leu Asp Gly Phe Met Ile Thr Leu 
1               5                   10  


<210>  583
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  583

Tyr Leu Val Gly Asn Val Cys Ile Leu 
1               5                   


<210>  584
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  584

Ser Thr Met Pro His Thr Ser Gly Met Asn Arg 
1               5                   10      


<210>  585
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  585

Gly Arg Lys Phe Ala Ala Trp Ala Pro Pro Ser Phe Ser Gln Thr 
1               5                   10                  15  


<210>  586
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  586

Gly Met Met Arg Trp Cys Met Pro Val 
1               5                   


<210>  587
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  587

Ala Val Val Phe Gln Asp Ser Val Val Phe Arg Val Ala Pro Trp 
1               5                   10                  15  


<210>  588
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  588

Thr Ser Ala Leu Pro Ile Ile Gln Lys 
1               5                   


<210>  589
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  589

Asp Gln Tyr Pro Tyr Leu Lys Ser Val 
1               5                   


<210>  590
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  590

Ile Ala Arg Asn Leu Thr Gln Gln Leu 
1               5                   


<210>  591
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  591

Ser Leu Leu Thr Ser Ser Lys Gly Gln Leu Gln Lys 
1               5                   10          


<210>  592
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  592

Thr Gly Ala Met Asn Val Ala Lys Gly Thr Ile Gln Thr Gly Val 
1               5                   10                  15  


<210>  593
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  593

Ala Thr Ala Gly Asp Gly Leu Ile Glu Leu Arg Lys 
1               5                   10          


<210>  594
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  594

Gly Ser Ser Asp Val Ile Ile His Arg 
1               5                   


<210>  595
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  595

Pro Tyr Gly Cys Leu Pro Thr Gly Asp Arg Thr Gly Leu Ile Glu 
1               5                   10                  15  


<210>  596
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  596

Ser Arg Ser Ser Ser Ala Glu Leu Asp Arg Ser Arg 
1               5                   10          


<210>  597
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  597

Ala Leu Gly Ile Gly Ile Tyr Ser Leu 
1               5                   


<210>  598
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  598

Lys Thr Trp Gly Gln Tyr Trp Gln Val 
1               5                   


<210>  599
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  599

Ser Ile Phe Asp Gly Arg Val Val Ala Lys 
1               5                   10  


<210>  600
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  600

Asp Leu Asp Val Lys Lys Met Pro Leu 
1               5                   


<210>  601
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  601

Ser Lys Met Gly Lys Trp Cys Arg His Cys Phe Pro Cys Cys Arg 
1               5                   10                  15  


<210>  602
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  602

Cys Arg Gly Ser Gly Lys Ser Asn Val Gly Thr Ser Gly Asp His 
1               5                   10                  15  


<210>  603
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  603

Ser Lys Met Gly Lys Trp Cys Arg His Cys Phe Ala Trp Cys Arg 
1               5                   10                  15  


<210>  604
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  604

Thr Arg Ala Thr Lys Met Gln Val Ile 
1               5                   


<210>  605
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  605

Val Tyr Ala Leu Pro Leu Lys Met Leu 
1               5                   


<210>  606
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  606

Tyr Ser Glu His Pro Thr Phe Thr Ser Gln Tyr 
1               5                   10      


<210>  607
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  607

Ala Val Gln Glu Phe Gly Leu Ala Arg Phe Lys 
1               5                   10      


<210>  608
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  608

Gly Glu Pro Ile Pro Gln Pro Ala Arg Leu Arg Tyr Val Thr Ser 
1               5                   10                  15  


<210>  609
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  609

Glu Met Gln Glu Glu Arg Leu Lys Leu Pro Ile Leu Ser Glu Glu 
1               5                   10                  15  


<210>  610
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  610

Val Met Leu Glu Gly Glu Gln Glu Glu 
1               5                   


<210>  611
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  611

His Ile Gly Ile Gly Leu Leu Ser Leu 
1               5                   


<210>  612
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  612

Ile Ser Glu Tyr Arg His Tyr Cys Tyr 
1               5                   


<210>  613
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  613

Lys Leu Pro Asp Leu Cys Thr Glu Leu 
1               5                   


<210>  614
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  614

Lys Leu Pro Gln Leu Cys Thr Glu Leu 
1               5                   


<210>  615
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  615

Thr Ile His Asp Ile Ile Leu Glu Cys Val 
1               5                   10  


<210>  616
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  616

Val Tyr Asp Phe Ala Phe Arg Asp Leu 
1               5                   


<210>  617
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  617

Asp Lys Lys Gln Arg Phe His Asn Ile Arg Gly Arg Trp Thr Gly Arg 
1               5                   10                  15      


Cys Met Ser Cys Cys Arg Ser Ser Arg Thr Arg Arg Glu Thr Gln Leu 
            20                  25                  30          


<210>  618
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  618

Phe Arg Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val 
1               5                   10                  15      


Cys Asp Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg His 
            20                  25                  30          


Tyr 
    


<210>  619
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  619

Lys Leu Pro Gln Leu Cys Thr Glu Leu Gln Thr Thr Ile His Asp Ile 
1               5                   10                  15      


Ile Leu Glu Cys Val Tyr Cys Lys Gln Gln Leu Leu Arg Arg Glu Val 
            20                  25                  30          


<210>  620
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  620

Met His Gln Lys Arg Thr Ala Met Phe Gln Asp Pro Gln Glu Arg Pro 
1               5                   10                  15      


Arg Lys Leu Pro Gln Leu Cys Thr Glu Leu Gln Thr Thr Ile His Asp 
            20                  25                  30          


Ile 
    


<210>  621
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  621

Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro Glu Glu Lys Gln Arg 
1               5                   10                  15      


His Leu Asp Lys Lys Gln Arg Phe His Asn Ile Arg Gly Arg Trp Thr 
            20                  25                  30          


<210>  622
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  622

Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Ile 
1               5                   10                  15  


<210>  623
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  623

Cys Val Tyr Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe 
1               5                   10                  15      


Ala Phe Arg Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala 
            20                  25                  30          


<210>  624
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  624

Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val Tyr 
1               5                   10                  15  


<210>  625
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  625

Arg Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys 
1               5                   10                  15      


Asp Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg His Tyr 
            20                  25                  30          


<210>  626
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  626

Val Tyr Asp Phe Ala Phe Arg Asp Leu Cys Ile Val Tyr Arg Asp 
1               5                   10                  15  


<210>  627
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  627

Phe Ala Phe Lys Asp Leu Cys Ile Val Tyr 
1               5                   10  


<210>  628
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  628

Phe Ala Phe Ser Asp Leu Tyr Val Val Tyr 
1               5                   10  


<210>  629
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  629

Phe Val Phe Ala Asp Leu Arg Ile Val Tyr 
1               5                   10  


<210>  630
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  630

Val Ala Phe Thr Glu Ile Lys Ile Val Tyr 
1               5                   10  


<210>  631
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  631

Asp Phe Ala Phe Arg Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro 
1               5                   10                  15      


Tyr Ala Val Cys Asp Lys 
            20          


<210>  632
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  632

Asp Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg His Tyr 
1               5                   10                  15      


Cys Tyr Ser Leu Tyr Gly 
            20          


<210>  633
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  633

Asp Pro Gln Glu Arg Pro Arg Lys Leu Pro Gln Leu Cys Thr Glu Leu 
1               5                   10                  15      


Gln Thr Thr Ile His Asp 
            20          


<210>  634
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  634

His Asp Ile Ile Leu Glu Cys Val Tyr Cys Lys Gln Gln Leu Leu Arg 
1               5                   10                  15      


Arg Glu Val Tyr Asp Phe 
            20          


<210>  635
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  635

Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg Asp 
1               5                   10                  15      


Leu Cys Ile Val Tyr Arg 
            20          


<210>  636
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  636

Arg Phe His Asn Ile Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys 
1               5                   10                  15      


Cys Arg Ser Ser Arg Thr 
            20          


<210>  637
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  637

Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp Lys Cys Leu Lys Phe 
1               5                   10                  15      


Tyr Ser Lys Ile Ser Glu 
            20          


<210>  638
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  638

Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg His Tyr Cys Tyr 
1               5                   10                  15      


Ser Leu Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu Cys 
            20                  25                  30          


Asp 
    


<210>  639
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  639

Asp Leu Phe Val Val Tyr Arg Asp Ser Ile Pro His Ala Ala Cys His 
1               5                   10                  15      


Lys Cys Ile Asp Phe Tyr 
            20          


<210>  640
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  640

Phe Tyr Ser Arg Ile Arg Glu Leu Arg His Tyr Ser Asp Ser Val Tyr 
1               5                   10                  15      


Gly Asp Thr Leu Glu Lys 
            20          


<210>  641
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  641

Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu Cys Asp Leu Leu 
1               5                   10                  15      


Ile Arg Cys Ile Asn Cys 
            20          


<210>  642
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  642

Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn Ile Arg Gly 
1               5                   10                  15      


Arg Trp Thr Gly Arg Cys 
            20          


<210>  643
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  643

Pro Leu Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu 
1               5                   10                  15      


Cys Pro Glu Glu Lys Gln 
            20          


<210>  644
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  644

Gln Glu Arg Pro Arg Lys Leu Pro Gln Leu 
1               5                   10  


<210>  645
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  645

Gln Arg Phe His Asn Ile Arg Gly Arg Trp 
1               5                   10  


<210>  646
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  646

Arg Trp Thr Gly Arg Cys Met Ser Cys Cys 
1               5                   10  


<210>  647
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  647

Ser Ser Arg Thr Arg Arg Glu Thr Gln Leu 
1               5                   10  


<210>  648
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  648

Ala Phe Arg Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr 
1               5                   10                  15  


<210>  649
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  649

His Leu Asp Lys Lys Gln Arg Phe His Asn Ile Arg Gly Arg Trp 
1               5                   10                  15  


<210>  650
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  650

Phe Ala Phe Arg Asp Leu Cys Ile Val Tyr Arg 
1               5                   10      


<210>  651
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  651

Met Leu Asp Leu Gln Pro Glu Thr Thr 
1               5                   


<210>  652
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  652

Tyr Ile Leu Asp Leu Gln Pro Glu Thr Thr 
1               5                   10  


<210>  653
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  653

Tyr Val Leu Asp Leu Gln Pro Glu Ala Thr 
1               5                   10  


<210>  654
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  654

Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys 
1               5                   10                  15      


Ser Gln Lys Pro 
            20  


<210>  655
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  655

Phe Gln Gln Leu Phe Leu Asn Thr Leu 
1               5                   


<210>  656
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  656

Gln Leu Phe Leu Asn Thr Leu Ser Phe Val 
1               5                   10  


<210>  657
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  657

Ala Ser Asp Leu Arg Thr Ile Gln Gln Leu Leu Met Gly Thr Val 
1               5                   10                  15  


<210>  658
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  658

Leu Arg Thr Ile Gln Gln Leu Leu Met Gly Thr Val Asn Ile Val 
1               5                   10                  15  


<210>  659
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  659

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu 
1               5                   10                  15  


<210>  660
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  660

His Val Asp Ile Arg Thr Leu Glu Asp Leu Leu Met Gly Thr Leu 
1               5                   10                  15  


<210>  661
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  661

Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser Glu Glu Glu Asp 
1               5                   10                  15      


Glu Ile Asp Gly Pro Ala 
            20          


<210>  662
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  662

His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr Leu Arg 
1               5                   10                  15      


Leu Cys Val Gln Ser Thr 
            20          


<210>  663
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  663

Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu Ser Asp Ser Glu Glu 
1               5                   10                  15      


Glu Asn Asp Glu Ile Asp 
            20          


<210>  664
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  664

Ile Arg Thr Leu Glu Asp Leu Leu Met Gly Thr 
1               5                   10      


<210>  665
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  665

Met His Gly Pro Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu 
1               5                   10                  15      


Pro Gln Asn Glu Ile Pro 
            20          


<210>  666
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  666

Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln Pro Glu Thr 
1               5                   10                  15  


<210>  667
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  667

Glu Met Ser Ala Leu Leu Ala Arg Arg Arg Arg Ile Ala Glu Lys 
1               5                   10                  15  


<210>  668
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  668

Arg Val Gln Glu Ala Val Glu Ser Met Val Lys 
1               5                   10      


<210>  669
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  669

Arg Tyr Tyr Val Gly His Lys Gly Lys Phe 
1               5                   10  


<210>  670
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  670

Lys Ile Phe Tyr Val Tyr Met Lys Arg Lys Tyr Glu Ala Met Thr 
1               5                   10                  15  


<210>  671
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  671

Lys Ala Ser Glu Lys Ile Phe Tyr Val 
1               5                   


<210>  672
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  672

Ala Thr Phe Ser Ser Ser His Arg Tyr His Lys 
1               5                   10      


<210>  673
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  673

Leu Leu His Gly Phe Ser Phe His Leu 
1               5                   


<210>  674
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  674

Glu Thr Asp Pro Val Asn His Met Val 
1               5                   


<210>  675
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  675

Gly Ile Asn Gln Thr Thr Gly Ala Leu Tyr Leu Arg Val Asp Ser 
1               5                   10                  15  


<210>  676
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  676

Gly Leu Gly Ile Gly Ile Ala Ser Met 
1               5                   


<210>  677
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  677

Ala Leu Leu Lys Asp Thr Val Tyr Thr 
1               5                   


<210>  678
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  678

Asn Leu Val His Gly Pro Pro Ala Pro Pro Gln Val Gly Ala Asp 
1               5                   10                  15  


<210>  679
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  679

Ala Leu Tyr Ser Gly Val His Lys Lys 
1               5                   


<210>  680
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  680

Gln Leu Leu Glu Gly Leu Gly Phe Thr Leu Thr Val Val Pro Glu 
1               5                   10                  15  


<210>  681
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  681

Glu Phe Pro Val Arg Gln Ala Ala Ala Ile Tyr Leu Lys 
1               5                   10              


<210>  682
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  682

Gly Gly Gly Pro Asp Gly Pro Leu Tyr Lys Val Ser Val Thr Ala 
1               5                   10                  15  


<210>  683
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  683

Ala Ala Ala Asn Ile Ile Arg Thr Leu 
1               5                   


<210>  684
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  684

Leu Gly Val Ile Gly Leu Val Ala Leu 
1               5                   


<210>  685
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  685

Ile Ile Ser Ala Val Val Gly Ile Leu 
1               5                   


<210>  686
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  686

Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
1               5                   10                  15      


Pro Ala 
        


<210>  687
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  687

His Pro Ala Ala Thr His Thr Lys Ala Val 
1               5                   10  


<210>  688
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  688

Gln Ile Lys Val Arg Val Asp Met Val 
1               5                   


<210>  689
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  689

Thr Leu Leu Gln Gln Tyr Cys Leu Tyr Leu 
1               5                   10  


<210>  690
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  690

Lys Ser Glu Gly Glu Glu Ala Gln Glu Val Glu Gly Glu Thr Gln 
1               5                   10                  15  


<210>  691
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  691

Ser Ser Leu Ser Leu Phe Phe Arg Lys 
1               5                   


<210>  692
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  692

Val Arg Arg Cys Leu Pro Leu Cys Ala Leu Thr Leu Glu Ala Ala 
1               5                   10                  15  


<210>  693
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  693

Arg Thr Asn Trp Pro Asn Thr Gly Lys 
1               5                   


<210>  694
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  694

Gly Arg Ala Pro Gln Val Leu Val Leu 
1               5                   


<210>  695
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  695

Thr Tyr Ser Pro Thr Ser Pro Val Tyr Thr Pro Thr Ser Pro Lys 
1               5                   10                  15  


<210>  696
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  696

Gly Gly His Asp Ser Ser Ser Trp Ser His Arg Tyr Gly Gly Gly 
1               5                   10                  15  


<210>  697
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  697

Asp Pro Ser Ala Ile Gly Leu Ala Asp Pro Pro Ile Pro Ser Pro 
1               5                   10                  15  


<210>  698
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  698

Ala Val Tyr Thr Pro Pro Ser Val Ser Thr His Gln Met Pro Arg 
1               5                   10                  15  


<210>  699
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  699

Gly Arg Leu Ile Leu Trp Glu Ala Pro Pro Leu Gly Ala Gly Gly 
1               5                   10                  15  


<210>  700
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  700

Ser Ile Tyr Asn Asn Leu Val Ser Phe Ala Ser Pro Leu Val Thr 
1               5                   10                  15  


<210>  701
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  701

Leu Leu Leu Glu Leu Ala Gly Val Thr His Val 
1               5                   10      


<210>  702
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  702

Asn Leu Lys Leu Lys Leu His Ser Phe 
1               5                   


<210>  703
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  703

Thr Arg Leu Phe Pro Asn Glu Phe Ala Asn Phe Tyr Asn Ala Val 
1               5                   10                  15  


<210>  704
<211>  20
<212>  PRT
<213>  Merkel cell polyomavirus

<400>  704

Cys Ile Ser Cys Lys Leu Ser Arg Gln His Cys Ser Leu Lys Thr Leu 
1               5                   10                  15      


Lys Gln Lys Asn 
            20  


<210>  705
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  705

Lys Leu Gly Ile Gly Phe Ala Lys Ala 
1               5                   


<210>  706
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  706

Phe Leu Gln Glu Val Asn Val Tyr Gly Val 
1               5                   10  


<210>  707
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  707

Leu Ile Gly Ile Gly Leu Asn Leu Val 
1               5                   


<210>  708
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  708

Ile Glu Glu Leu Arg His Leu Trp Asp Leu Leu Leu Glu Leu Thr Leu 
1               5                   10                  15      


<210>  709
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  709

Lys Glu Leu Arg Ala Leu Arg Lys Met Val Ser Asn Met Ser Gly 
1               5                   10                  15  


<210>  710
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  710

Tyr Thr Cys Pro Leu Cys Arg Ala Pro Val 
1               5                   10  


<210>  711
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  711

Ile Met Leu Glu Gly Glu Thr Lys Leu 
1               5                   


<210>  712
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  712

Gln Gln Glu Ile Asp Gln Lys Arg Leu Glu Phe Glu Lys Gln Lys 
1               5                   10                  15  


<210>  713
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  713

Ala Gly Arg Phe Gly Gln Gly Ala His His Ala Ala Gly Gln Ala 
1               5                   10                  15  


<210>  714
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  714

Arg Leu Phe Val Gly Ser Ile Pro Lys 
1               5                   


<210>  715
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  715

Gly Tyr Asp Gln Ile Met Pro Lys Lys 
1               5                   


<210>  716
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  716

Ala Pro Leu Gln Arg Ser Gln Ser Leu 
1               5                   


<210>  717
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  717

Glu Pro Gly Asp Thr Ala Leu Tyr Leu Cys Ala Ser Ser Gln Ser 
1               5                   10                  15  


<210>  718
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  718

Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile Pro 
1               5                   10      


<210>  719
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  719

Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile Pro Lys 
1               5                   10                  15      


<210>  720
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  720

Leu Leu Thr Ser Arg Leu Arg Phe 
1               5               


<210>  721
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  721

Leu Leu Thr Ser Arg Leu Arg Phe Ile 
1               5                   


<210>  722
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  722

Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile 
1               5                   10          


<210>  723
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  723

Gly Thr Ala Asp Val His Phe Glu Arg 
1               5                   


<210>  724
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  724

Ala Ser Phe Asp Lys Ala Lys Leu Lys 
1               5                   


<210>  725
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  725

Pro Thr Lys Cys Glu Val Glu Arg Phe Thr Ala Thr Ser Phe Gly 
1               5                   10                  15  


<210>  726
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  726

Glu Ser Asp Pro Ile Val Ala Gln Tyr 
1               5                   


<210>  727
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  727

Ser Ile Leu Glu Asp Pro Pro Ser Ile 
1               5                   


<210>  728
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  728

Gly Asp Cys Val Gln Gly Asp Trp Cys Pro Ile Ser Gly Gly Leu 
1               5                   10                  15  


<210>  729
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  729

Ile Ser Gly Gly Leu Cys Ser Ala Arg Leu His Arg His Ala Leu 
1               5                   10                  15  


<210>  730
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  730

Leu Leu Phe Gly Tyr Pro Val Tyr Val 
1               5                   


<210>  731
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  731

Ser Phe His Ser Leu His Leu Leu Phe 
1               5                   


<210>  732
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  732

Val Val Cys Met Tyr Leu Tyr Gln Leu Ser Pro Pro Ile Thr Trp 
1               5                   10                  15  


<210>  733
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  733

Ala Gly Gln Asn Pro Ala Ser His Pro Pro Pro Asp Asp Ala Glu 
1               5                   10                  15  


<210>  734
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  734

Arg Val Glu Tyr His Phe Leu Ser Pro Tyr Val Ser Pro Lys 
1               5                   10                  


<210>  735
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  735

Asn Ser Val Ile Ile Val Asp Lys Asn Gly Arg Leu Val 
1               5                   10              


<210>  736
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  736

Ile Leu Leu Gly Ile Gly Ile Tyr Ala Leu 
1               5                   10  


<210>  737
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  737

Leu Leu Gly Ile Gly Ile Tyr Ala Leu 
1               5                   


<210>  738
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  738

Ile His Ser Ser Trp Asp Cys Gly Leu Phe Thr Asn Tyr Ser Ala 
1               5                   10                  15  


<210>  739
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  739

Gln Leu Leu Asp Gln Val Glu Gln Ile 
1               5                   


<210>  740
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  740

Ile Met Ala Ser Lys Gly Met Arg His Phe Cys Leu Ile Ser Glu 
1               5                   10                  15  


<210>  741
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  741

Met Arg His Phe Cys Leu Ile Ser Glu 
1               5                   


<210>  742
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  742

Ile Ala Gly Leu Gly Leu Leu Thr Val 
1               5                   


<210>  743
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  743

Gly Glu Leu Ile Gly Thr Leu Asn Ala Ala Lys Val Pro Ala Asp 
1               5                   10                  15  


<210>  744
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  744

Gln Val Ala Thr Glu Gly Leu Ala Lys 
1               5                   


<210>  745
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  745

Arg Leu Ala Arg Leu Ala Leu Val Leu 
1               5                   


<210>  746
<211>  20
<212>  PRT
<213>  Merkel cell polyomavirus

<400>  746

Pro Asn Gly Thr Ser Val Pro Arg Asn Ser Ser Arg Thr Tyr Gly Thr 
1               5                   10                  15      


Trp Glu Asp Leu 
            20  


<210>  747
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  747

Met Arg Glu Thr Ser Gly Phe Thr Leu 
1               5                   


<210>  748
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  748

Ala Val Phe Asp Gly Ala Gln Val Thr Ser Lys 
1               5                   10      


<210>  749
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  749

Tyr Met Asp Gly Thr Met Ser Gln Val 
1               5                   


<210>  750
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  750

Met Leu Leu Ala Val Leu Tyr Cys Leu 
1               5                   


<210>  751
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  751

Tyr Met Asn Gly Thr Met Ser Gln Val 
1               5                   


<210>  752
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  752

Phe Gln Asp Tyr Ile Lys Ser Tyr Leu 
1               5                   


<210>  753
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  753

Ser Val Tyr Asp Phe Phe Val Trp Leu 
1               5                   


<210>  754
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  754

Pro Lys Pro Val Leu His Met Val Ser Ser Glu Gln His Ser Ala 
1               5                   10                  15  


<210>  755
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  755

Tyr Leu Ala Pro Glu Asn Gly Tyr Leu 
1               5                   


<210>  756
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  756

Lys Met Gly Ile Gly Trp Lys Pro Leu 
1               5                   


<210>  757
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  757

His Tyr Tyr Val Ser Met Asp Ala Leu 
1               5                   


<210>  758
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  758

Lys Tyr Lys Asp Arg Thr Asn Ile Leu Phe 
1               5                   10  


<210>  759
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  759

Arg Leu Pro Ser Ser Ala Asp Val Glu Phe 
1               5                   10  


<210>  760
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  760

Arg Tyr Asn Ala Asp Ile Ser Thr Phe 
1               5                   


<210>  761
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  761

Gln Glu Glu Lys Ser Leu Asp Pro Met Val Tyr Met Asn Asp Thr Ser 
1               5                   10                  15      


Pro Leu Thr 
            


<210>  762
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  762

Thr Cys Ser Cys Gln Ser Ser Gly Thr Ser Ser Thr Ser Tyr Ser 
1               5                   10                  15  


<210>  763
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  763

Thr Ile Tyr Ser Leu Phe Tyr Ser Val Ala Asp Arg Asp Ala Pro Ala 
1               5                   10                  15      


<210>  764
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  764

Gly Ala Ile Val Ile Glu Arg Pro Asn Val Lys Trp Ser 
1               5                   10              


<210>  765
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  765

Asp Ile Met Arg Val Asn Val Asp Lys Val Leu Glu Arg Asp Gln Lys 
1               5                   10                  15      


Leu 
    


<210>  766
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  766

Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp Asp 
1               5                   10                  15      


Arg 
    


<210>  767
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  767

Ser Ser Val Pro Gly Val Arg Leu Leu 
1               5                   


<210>  768
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  768

Asn Tyr Ile Asp Lys Val Arg 
1               5           


<210>  769
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  769

Cys Gln Trp Gly Arg Leu Trp Gln Leu 
1               5                   


<210>  770
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  770

Met Cys Gln Trp Gly Arg Leu Trp Gln Leu 
1               5                   10  


<210>  771
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  771

Cys Met Thr Trp Asn Gln Met Asn Leu 
1               5                   


<210>  772
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  772

Arg Met Phe Pro Asn Ala Pro Tyr Leu 
1               5                   


<210>  773
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  773

Ser Gly Ser Gly Ser Gly Pro Leu Pro Ser Leu Phe Leu Asn Ser 
1               5                   10                  15  


<210>  774
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  774

Leu Thr Asp His Arg Ala His Arg Cys Pro Gly Gly Asn Ala Lys 
1               5                   10                  15  


<210>  775
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  775

Gln Leu Thr Ala His Lys Met Ile His Thr Gly Glu Lys Pro Tyr 
1               5                   10                  15  


<210>  776
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  776

Glu Cys Ser Glu Cys Gly Lys Val Phe Leu Glu Ser Ala Ala Leu 
1               5                   10                  15  


<210>  777
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  777

Glu Glu Cys Gly Lys Ala Phe Ser Val Phe Ser Thr Leu Thr Lys 
1               5                   10                  15  


<210>  778
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  778

Val Thr Gly Gly Arg Gly Gly Arg Gln Gly Pro Ser Pro Ala Phe 
1               5                   10                  15  


<210>  779
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  779

Cys Asn Phe Ser Thr Ile Asp Val Val Ser Leu Lys Thr Asp Thr 
1               5                   10                  15  


<210>  780
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  780

Leu Thr Asp His Arg Ala His Arg Cys Pro Gly Asp Gly Asp Asp 
1               5                   10                  15  


<210>  781
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  781

Ser Asn Leu Thr Lys His Lys Lys Ile His Ile Glu Lys Lys Pro 
1               5                   10                  15  


<210>  782
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  782

Ile His Lys Met Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu 
1               5                   10                  15  


<210>  783
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  783

Leu Gln Asn His Ile Gln Thr Ile His Arg Glu Leu Val Pro Asp 
1               5                   10                  15  


<210>  784
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  784

Asn Val Ala Lys Pro Ser Ser Gly Pro His Thr Leu Leu His Ile 
1               5                   10                  15  


<210>  785
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  785

Ser Asn Leu Thr Thr His Lys Lys Ile His Thr Gly Glu Arg Pro 
1               5                   10                  15  


<210>  786
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  786

Glu Lys Pro Tyr Ser Cys Pro Asp Cys Ser Leu Arg Phe Ala Tyr 
1               5                   10                  15  


<210>  787
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  787

Lys Cys Glu Glu Cys Asp Thr Val Phe Ser Arg Lys Ser His His 
1               5                   10                  15  


<210>  788
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  788

Gly Cys Gly Lys Val Phe Ala Arg Ser Glu Asn Leu Lys Ile His 
1               5                   10                  15  


<210>  789
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  789

Arg Tyr Gln Gln Trp Met Glu Arg Phe 
1               5                   


<210>  790
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  790

Ser Ala Gly Pro Pro Ser Leu Arg Lys 
1               5                   


<210>  791
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  791

Pro Met Glu Lys Pro Thr Ile Ser Thr Glu Lys Pro Thr Ile Pro 
1               5                   10                  15  


<210>  792
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  792

Ala Pro Ile Trp Pro Tyr Glu Ile Leu Tyr 
1               5                   10  


<210>  793
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  793

Cys Tyr Thr Trp Asn Gln Met Asn Leu 
1               5                   


<210>  794
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  794

Asp Ala Glu Lys Ser Asp Ile Cys Thr Asp Glu Tyr 
1               5                   10          


<210>  795
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  795

Glu Leu Ala Gly Ile Gly Ile Leu Thr Val 
1               5                   10  


<210>  796
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  796

Ile Met Asp Gln Val Pro Phe Ser Val 
1               5                   


<210>  797
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  797

Lys Leu Cys Pro Val Gln Leu Trp Val 
1               5                   


<210>  798
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  798

Leu Met Leu Gly Glu Phe Leu Lys Leu 
1               5                   


<210>  799
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  799

Ser Leu Leu Met Trp Ile Thr Gln Ala 
1               5                   


<210>  800
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  800

Ser Leu Leu Met Trp Ile Thr Gln Val 
1               5                   


<210>  801
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  801

Ser Leu Pro Pro Pro Gly Thr Arg Val 
1               5                   


<210>  802
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  802

Thr Leu Gly Ile Val Cys Pro Ile 
1               5               


<210>  803
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  803

Val Leu Pro Asp Val Phe Ile Arg Cys 
1               5                   


<210>  804
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  804

Tyr Leu Glu Pro Gly Pro Val Thr Leu 
1               5                   


<210>  805
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  805

Tyr Leu Glu Pro Gly Pro Val Thr Val 
1               5                   


<210>  806
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  806

Tyr Leu Glu Pro Gly Pro Val Thr Val Pro 
1               5                   10  


<210>  807
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  807

Tyr Leu Gly Ser Tyr Gly Phe Arg Leu 
1               5                   


<210>  808
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  808

Gly Glu Leu Ile Gly Ile Leu Asn Ala Ala Lys Val Pro Ala Asp 
1               5                   10                  15  


<210>  809
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  809

Ala Leu Gly Ile Gly Ile Leu Thr Val 
1               5                   


<210>  810
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  810

Lys Ala Val Ala Ala Trp Thr Leu Lys Ala Ala 
1               5                   10      


<210>  811
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  811

Phe Ala Thr Gly Ile Gly Ile Ile Thr Val 
1               5                   10  


<210>  812
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  812

Phe Leu Thr Gly Ile Gly Ile Ile Thr Val 
1               5                   10  


<210>  813
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  813

Ala Leu Ala Gly Ile Gly Ile Leu Thr Val 
1               5                   10  


<210>  814
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  814

Glu Leu Ala Ala Ile Gly Ile Leu Thr Val 
1               5                   10  


<210>  815
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  815

Glu Leu Ala Gly Ile Gly Ile Leu Ala Val 
1               5                   10  


<210>  816
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  816

Gly Val Ala Gly Ile Gly Ile Leu Thr Gly 
1               5                   10  


<210>  817
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  817

Ser Ala Ala Gly Ile Gly Ile Leu Thr Val 
1               5                   10  


<210>  818
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  818

Ser Val Tyr Asp Phe Phe Val Trp Leu 
1               5                   


<210>  819
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  819

Ala Leu Glu Pro Gly Pro Val Thr Ala 
1               5                   


<210>  820
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  820

Tyr Leu Glu Ala Gly Pro Val Thr Ala 
1               5                   


<210>  821
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  821

Tyr Leu Glu Pro Gly Ala Val Thr Ala 
1               5                   


<210>  822
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  822

Tyr Leu Glu Pro Gly Pro Ala Thr Ala 
1               5                   


<210>  823
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  823

Tyr Leu Glu Pro Gly Pro Val Ala Ala 
1               5                   


<210>  824
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  824

Ala Met Phe Trp Ser Val Pro Thr Val 
1               5                   


<210>  825
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  825

Cys Leu Asn Glu Tyr His Leu Phe Leu 
1               5                   


<210>  826
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  826

Glu Tyr Tyr Ser Lys Asn Leu Asn Ser Phe 
1               5                   10  


<210>  827
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  827

Phe Leu Tyr Asn Leu Leu Thr Arg Val 
1               5                   


<210>  828
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  828

Gly Leu Gly Pro Gly Phe Ser Ser Tyr 
1               5                   


<210>  829
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  829

His Leu Tyr Ala Ser Leu Ser Arg Val 
1               5                   


<210>  830
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  830

Ile Ile Leu Val Ala Val Pro His Val 
1               5                   


<210>  831
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  831

Lys Leu Met Asn Ile Gln Gln Lys Leu 
1               5                   


<210>  832
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  832

Lys Met Ile Gly Asn His Leu Trp Val 
1               5                   


<210>  833
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  833

Met Leu Gly Glu Gln Leu Phe Pro Leu 
1               5                   


<210>  834
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  834

Gln Leu Ser Cys Ile Ser Thr Tyr Val 
1               5                   


<210>  835
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  835

Thr Tyr Leu Pro Ser Ala Trp Asn Phe 
1               5                   


<210>  836
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  836

Thr Tyr Leu Pro Ser Ala Trp Asn Phe Phe 
1               5                   10  


<210>  837
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  837

Val Tyr Gln Tyr Thr Phe Pro Asp Phe 
1               5                   


<210>  838
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  838

Val Tyr Gln Tyr Thr Phe Pro Asp Phe Leu 
1               5                   10  


<210>  839
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  839

Tyr Gln Tyr Thr Phe Pro Asp Phe 
1               5               


<210>  840
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  840

Tyr Gln Tyr Thr Phe Pro Asp Phe Leu Tyr 
1               5                   10  


<210>  841
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  841

Tyr Ser Lys Asn Leu Asn Ser Phe Phe 
1               5                   


<210>  842
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  842

Tyr Tyr Ser Lys Asn Leu Asn Ser Phe 
1               5                   


<210>  843
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  843

Tyr Tyr Ser Lys Asn Leu Asn Ser Phe Phe 
1               5                   10  


<210>  844
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  844

Ala Val Cys Pro Trp Thr Trp Leu Arg 
1               5                   


<210>  845
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  845

Ala Pro Ala Arg Leu Glu Arg Arg His Ser Ala 
1               5                   10      


<210>  846
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  846

Gly Glu Glu Asp Gly Ala Gly Gly His Ser Leu 
1               5                   10      


<210>  847
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  847

Gly Leu Leu Asp Glu Asp Phe Tyr Ala 
1               5                   


<210>  848
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  848

Gly Gln Phe Leu Thr Pro Asn Ser His 
1               5                   


<210>  849
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  849

His Gln Asn Pro Val Thr Gly Leu Leu Leu 
1               5                   10  


<210>  850
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  850

Arg His Asp Leu Pro Pro Tyr Arg Val Tyr Leu 
1               5                   10      


<210>  851
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  851

Arg Lys Thr Val Arg Ala Arg Ser Arg Thr Pro Ser Cys Arg Ser Arg 
1               5                   10                  15      


Ser His Thr Pro Ser Arg Arg Arg Arg 
            20                  25  


<210>  852
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  852

Arg Val Ser Thr Leu Arg Val Ser Leu 
1               5                   


<210>  853
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  853

Ser Trp Ile Ser Asp Ile Arg Ala Gly Thr Ala Pro Leu Cys Arg Asn 
1               5                   10                  15      


His Ile Lys Ser Ser Cys Ser Leu Ile 
            20                  25  


<210>  854
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  854

Ser Tyr Met Ile Met Glu Ile Glu Leu 
1               5                   


<210>  855
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  855

Thr Leu Trp Cys Ser Pro Ile Lys Val 
1               5                   


<210>  856
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  856

Val Leu Leu Gly Val Lys Leu Phe Gly Val 
1               5                   10  


<210>  857
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  857

Trp Leu Ile Arg Glu Thr Gln Pro Ile Thr Lys 
1               5                   10      


<210>  858
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  858

Tyr His Ser Ile Glu Trp Ala Ile 
1               5               


<210>  859
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  859

Glu Ala Lys Pro Ser Arg Ile Leu Met 
1               5                   


<210>  860
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  860

Gly Ile Ala Ala Arg Val Lys Asn Trp Leu 
1               5                   10  


<210>  861
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  861

Lys Glu Gly Ile Ala Ala Arg Val Lys Asn Trp 
1               5                   10      


<210>  862
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  862

Trp Glu Ala Lys Pro Ser Arg Ile Leu 
1               5                   


<210>  863
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  863

Ala Ala Arg Gly Pro His Gly Gly Ala Ala Ser Gly Leu 
1               5                   10              


<210>  864
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  864

Ala Pro Ala Gly Pro His Gly Gly Ala Ala Ser Gly Leu 
1               5                   10              


<210>  865
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  865

Ala Pro Arg Gly Ala His Gly Gly Ala Ala Ser Gly Leu 
1               5                   10              


<210>  866
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  866

Ala Pro Arg Gly Pro Ala Gly Gly Ala Ala Ser Gly Leu 
1               5                   10              


<210>  867
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  867

Ala Pro Arg Gly Pro His Ala Gly Ala Ala Ser Gly Leu 
1               5                   10              


<210>  868
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  868

Ala Pro Arg Gly Pro His Gly Gly Ala Ala Ala Gly Leu 
1               5                   10              


<210>  869
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  869

Ala Pro Arg Gly Pro His Gly Gly Ala Ala Ser Ala Leu 
1               5                   10              


<210>  870
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  870

Ala Pro Arg Gly Pro His Gly Gly Ala Ala Ser Gly Ala 
1               5                   10              


<210>  871
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  871

Gly Arg Ile Ala Phe Phe Leu Lys Tyr 
1               5                   


<210>  872
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  872

Lys Leu Ile Leu Trp Arg Gly Leu Lys 
1               5                   


<210>  873
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  873

Ile Leu Glu Asp Arg Gly Phe Asn Gln Val 
1               5                   10  


<210>  874
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  874

Ile Met Glu Asp Val Gly Trp Leu Asn Val 
1               5                   10  


<210>  875
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  875

Leu Met Phe Asp Arg Gly Met Ser Leu Leu 
1               5                   10  


<210>  876
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  876

Met Met Trp Asp Ala Gly Leu Gly Met Met 
1               5                   10  


<210>  877
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  877

Met Met Trp Asp Arg Gly Ala Gly Met Met 
1               5                   10  


<210>  878
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  878

Met Met Trp Asp Arg Gly Leu Gly Ala Met 
1               5                   10  


<210>  879
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  879

Met Met Trp Asp Arg Gly Leu Gly Met 
1               5                   


<210>  880
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  880

Met Met Trp Asp Arg Gly Leu Gly Met Met 
1               5                   10  


<210>  881
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  881

Met Met Trp Asp Arg Gly Met Gly Leu Leu 
1               5                   10  


<210>  882
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  882

Asn Leu Ser Asn Leu Gly Ile Leu Val 
1               5                   


<210>  883
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  883

Asn Met Gly Gly Leu Gly Ile Met Pro Val 
1               5                   10  


<210>  884
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  884

Ser Met Ala Gly Ile Gly Ile Val Asp Val 
1               5                   10  


<210>  885
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  885

Ser Met Leu Gly Ile Gly Ile Val Pro Val 
1               5                   10  


<210>  886
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  886

Cys Met Trp Gly Arg Leu Trp Gln Leu 
1               5                   


<210>  887
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  887

Asn Leu Ser Asn Leu Gly Ile Leu Pro Val 
1               5                   10  


<210>  888
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  888

Ser Leu Ala Asn Ile Gly Ile Leu Pro Val 
1               5                   10  


<210>  889
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  889

Ile Thr Ser Ala Ile Gly Ile Leu Pro Val 
1               5                   10  


<210>  890
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  890

Ile Thr Ser Ala Ile Gly Val Leu Phe Val 
1               5                   10  


<210>  891
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  891

Ile Thr Ser Ala Ile Gly Val Leu Pro Ile 
1               5                   10  


<210>  892
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  892

Ile Thr Ser Ala Ile Gly Val Leu Pro Val 
1               5                   10  


<210>  893
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  893

Ile Thr Ser Gly Ile Gly Val Leu Pro Val 
1               5                   10  


<210>  894
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  894

Leu Thr Ser Ala Ile Gly Val Leu Pro Val 
1               5                   10  


<210>  895
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  895

Met Thr Ser Ala Ile Gly Ile Leu Pro Val 
1               5                   10  


<210>  896
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  896

Met Thr Ser Ala Ile Gly Val Leu Pro Val 
1               5                   10  


<210>  897
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  897

Gln Thr Ser Ala Ile Gly Ile Leu Pro Val 
1               5                   10  


<210>  898
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  898

Gln Thr Ser Ala Ile Gly Val Leu Pro Val 
1               5                   10  


<210>  899
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  899

Phe Ile Leu Leu Leu Phe Leu Thr Ile Phe Ile 
1               5                   10      


<210>  900
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  900

Phe Ile Ser Ile Phe Phe Phe Leu Glu Ile 
1               5                   10  


<210>  901
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  901

Phe Met Asp Met Ala Ile Leu Val Glu Ser 
1               5                   10  


<210>  902
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  902

Ile Leu Leu Leu Phe Leu Thr Ile Phe Ile 
1               5                   10  


<210>  903
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  903

Leu Leu Phe Leu Thr Ile Phe Ile Tyr Ala 
1               5                   10  


<210>  904
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  904

Leu Leu Leu Phe Leu Thr Ile Phe Ile 
1               5                   


<210>  905
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  905

Arg Leu Met Val Ala Val Glu Glu Ala 
1               5                   


<210>  906
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  906

Arg Leu Met Val Ala Val Glu Glu Ala Phe Ile 
1               5                   10      


<210>  907
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  907

Asp Leu Ala Gly Ile Gly Ile Leu Thr Val 
1               5                   10  


<210>  908
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  908

Glu Ile Ala Gly Ile Gly Ile Leu Thr Val 
1               5                   10  


<210>  909
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  909

Glu Leu Ala Gly Ile Gly Ile Ile Thr Val 
1               5                   10  


<210>  910
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  910

Glu Leu Ala Gly Ile Gly Ile Leu Ser Val 
1               5                   10  


<210>  911
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  911

Glu Leu Ala Gly Ile Gly Ile Leu Thr Ala 
1               5                   10  


<210>  912
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  912

Glu Leu Ala Gly Ile Gly Ile Leu Thr Ile 
1               5                   10  


<210>  913
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  913

Glu Leu Ala Gly Ile Gly Leu Leu Thr Val 
1               5                   10  


<210>  914
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  914

Glu Leu Gly Gly Ile Gly Ile Leu Thr Val 
1               5                   10  


<210>  915
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  915

Ala Tyr Arg Asp Leu Gln Thr Arg Lys 
1               5                   


<210>  916
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  916

Glu Gly Thr Lys Gly Ala Thr Met Asp Leu Glu Ile Val Asn Leu Pro 
1               5                   10                  15      


Asn Val Glu Ile Ser Lys Asp Leu Ser 
            20                  25  


<210>  917
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  917

Glu Trp Asp Pro Leu Asp Ile Ala Phe Glu Thr Trp Asp Ile Ile Phe 
1               5                   10                  15      


Arg Asn Met Asn Lys Glu Asp Glu Gly 
            20                  25  


<210>  918
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  918

Gly Lys Ala Phe Gly Leu Cys Ser Ile Phe Thr Glu Gln Lys Lys Ile 
1               5                   10                  15      


Phe Ser Arg Glu Lys Cys Tyr Lys Cys 
            20                  25  


<210>  919
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  919

His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly Ser Met Asn Arg 
1               5                   10                  15      


Arg Pro Ile Leu Thr Ile Ile Thr Leu 
            20                  25  


<210>  920
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  920

Ile Leu Gln Tyr Leu Asp Ser Glu Arg Arg Gln Ile Arg Ile Ala Lys 
1               5                   10                  15      


Ser Pro Leu Ala Pro Phe Thr Ser Phe 
            20                  25  


<210>  921
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  921

Lys Gln His Val Cys Gly Gly Ser Ile Leu Asp Pro Tyr Trp Val Leu 
1               5                   10                  15      


Thr Ala Ala His Cys Phe Arg Lys His 
            20                  25  


<210>  922
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  922

Leu Gly Ser Arg Glu Leu Phe Cys Ser Lys Leu Arg Arg Ala Ala Val 
1               5                   10                  15      


Phe Pro Pro Ala His Gln Gln Arg Thr 
            20                  25  


<210>  923
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  923

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Val Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile 
            20                  


<210>  924
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  924

Asn Thr Val Phe Gly Ala Glu Arg Lys Lys Arg Leu Phe Ile Ile Gly 
1               5                   10                  15      


Pro Thr Ser Arg Asp Arg Ser Ser Pro 
            20                  25  


<210>  925
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  925

Pro Ala Ile Arg Val Pro Pro Val Ile Pro Leu Gly Ser Arg Glu Leu 
1               5                   10                  15      


Phe Cys Ser Lys Leu Arg Arg Ala Ala 
            20                  25  


<210>  926
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  926

Pro Gly Ile Ser Ser Gln His Phe Thr Tyr Gln Gly Gly Val Gly Gly 
1               5                   10                  15      


Ser Trp Pro Val Cys Ser Gly Leu Gly 
            20                  25  


<210>  927
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  927

Pro Thr Pro Ser Ala Pro Cys Pro Ala Thr Pro Ala Val Pro Lys Gly 
1               5                   10                  15      


Arg Val Phe Val Ser Pro Leu Ala Lys 
            20                  25  


<210>  928
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  928

Ser Phe Val Asn Asp Ile Phe Glu Arg Ile Ala Gly Val Ala Ser Arg 
1               5                   10                  15      


Leu Ala His Tyr Asn Lys Arg Ser Thr 
            20                  25  


<210>  929
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  929

Ser Leu Ala Ala Leu Lys Lys Ala Leu Ala Asp Gly Gly Tyr Asp Val 
1               5                   10                  15      


Glu Lys Asn Asn Ser Arg Ile 
            20              


<210>  930
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  930

Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Thr Val Ala Glu 
1               5                   10                  15      


Ile Thr Asn Ala Cys Phe Glu Pro Ala 
            20                  25  


<210>  931
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  931

Val Arg Leu Ala Gln Gly Leu Thr His Leu Gly Lys Ala Thr Leu Thr 
1               5                   10                  15      


Leu Cys Pro Tyr His Ser Asp Arg Gln 
            20                  25  


<210>  932
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  932

Phe Ile Ser Asn Thr Val Phe Arg Lys 
1               5                   


<210>  933
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  933

Phe Leu Phe Glu Leu Ile Pro Glu Pro 
1               5                   


<210>  934
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  934

Phe Leu Gly Glu Ala Trp Ala Gln Val 
1               5                   


<210>  935
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  935

Phe Val Gly Ala Leu Ser Phe Ser Ile 
1               5                   


<210>  936
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  936

Ile Leu Gly Ile Phe Asn Glu Phe Val 
1               5                   


<210>  937
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  937

Ile Leu Ser Pro Ser Ala His Glu Leu 
1               5                   


<210>  938
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  938

Ile Met Ser Ser Ser Leu Phe Asn Leu 
1               5                   


<210>  939
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  939

Lys Ile Tyr Arg Arg Gln Ile Phe Lys 
1               5                   


<210>  940
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  940

Lys Leu Ala Asp Tyr Leu Asn Val Leu 
1               5                   


<210>  941
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  941

Lys Val Phe Glu His Val Gly Ser Arg 
1               5                   


<210>  942
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  942

Leu Leu His Gly Phe Ser Phe Tyr Leu 
1               5                   


<210>  943
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  943

Leu Leu Val Asp Leu Ala Glu Glu Leu 
1               5                   


<210>  944
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  944

Leu Pro Arg Ala Lys Lys Leu Ile Leu 
1               5                   


<210>  945
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  945

Asn Leu Arg Tyr Phe Ala Lys Ser Leu 
1               5                   


<210>  946
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  946

Gln Met Ile Tyr Ser Ala Ala Arg Val 
1               5                   


<210>  947
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  947

Arg Leu Phe Gly Glu Ala Pro Arg Glu Leu 
1               5                   10  


<210>  948
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  948

Arg Leu Ser Asp Phe Ser Glu Gln Leu 
1               5                   


<210>  949
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  949

Arg Met Trp Asp Phe Asp Ile Phe Leu 
1               5                   


<210>  950
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  950

Ser Leu Leu Arg Ser Leu Glu Asn Val 
1               5                   


<210>  951
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  951

Ser Leu Arg Ser His His Tyr Ser Leu 
1               5                   


<210>  952
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  952

Val Leu Asp Gly Phe Ile Pro Gly Thr 
1               5                   


<210>  953
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  953

Val Leu Gln Glu Ala Thr Ile Cys Val 
1               5                   


<210>  954
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  954

Trp Val Leu Ala Leu Phe Asp Glu Val 
1               5                   


<210>  955
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  955

Tyr Ile Leu Lys Tyr Ser Val Phe Leu 
1               5                   


<210>  956
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  956

Asp Ala Asn Ser Phe Leu Gln Ser Val 
1               5                   


<210>  957
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  957

Thr Glu Tyr Lys Leu Val Val Val Gly Ala Val Gly Val Gly Lys Ser 
1               5                   10                  15      


Ala Leu Thr Ile Gln 
            20      


<210>  958
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  958

Ala Gly Ala Phe Leu Ser Ser Pro Gly Leu Leu Ala Val Phe Gly 
1               5                   10                  15  


<210>  959
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  959

Ala Arg Gly Gly Leu Val Asp Glu Lys Ala Leu Ala Arg Ala Leu Lys 
1               5                   10                  15      


Glu Gly Arg Ile Arg Gly Ala Ala Leu 
            20                  25  


<210>  960
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  960

Phe Glu Asp Lys Ser Val Ala Tyr Thr 
1               5                   


<210>  961
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  961

Phe Tyr Asn Asp Ile Ile Leu Met Val 
1               5                   


<210>  962
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  962

Gly Phe Pro Ala Glu Arg Leu Glu Gly Val Tyr Ser Asn Asn Ile 
1               5                   10                  15  


<210>  963
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  963

Gly Leu Asn Phe Val Ser Val Lys Gly Pro Glu Leu Leu Asn Met 
1               5                   10                  15  


<210>  964
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  964

Lys Ala Leu Ala Arg Ala Leu Lys Glu Gly Arg Ile Arg 
1               5                   10              


<210>  965
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  965

Leu Ile Leu Phe Phe His Thr Leu Gly Leu Gln Thr Lys Glu Glu 
1               5                   10                  15  


<210>  966
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  966

Asn Asn Thr Asp Ile Arg Leu Ile Gly Glu Lys Leu Phe His Gly 
1               5                   10                  15  


<210>  967
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  967

Arg Tyr Tyr Val Gly His Lys Ala Lys Phe 
1               5                   10  


<210>  968
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  968

Tyr Glu Gly Gln Val Ile Ser Asn Gly Phe 
1               5                   10  


<210>  969
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  969

Cys Leu Trp Gly Arg Leu Trp Gln Leu 
1               5                   


<210>  970
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  970

Ala Leu Pro Leu Ser Glu Pro Met Arg Arg Ser Val Ser Glu Glu 
1               5                   10                  15  


<210>  971
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  971

Glu Met Ser Ala Leu Leu Ala Arg Arg Arg Arg Ile Val Glu Lys 
1               5                   10                  15  


<210>  972
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  972

Phe Leu Gln Glu Val Asn Val Cys Gly Val 
1               5                   10  


<210>  973
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  973

Lys Leu Val Val Val Gly Ala Asp Gly Val 
1               5                   10  


<210>  974
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  974

Leu Lys Leu Met Ala Tyr Leu Ala Gly Ala Lys Tyr Thr Gly Cys 
1               5                   10                  15  


<210>  975
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  975

Leu Leu Lys Ala Glu Leu Val Ala Gly Leu 
1               5                   10  


<210>  976
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  976

Pro Lys Pro Val Leu His Met Val Ser Ser Glu Gln His Ser Gly 
1               5                   10                  15  


<210>  977
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  977

Gln Trp Ile Asn Tyr Phe Asp Lys Arg Arg Asp Tyr Leu Lys Phe 
1               5                   10                  15  


<210>  978
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  978

Arg Thr Asp Leu Val Lys Ser Glu Leu Leu His Ile Glu Cys Gln 
1               5                   10                  15  


<210>  979
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  979

Ser Glu Ile Val Pro Cys Leu Ser Glu Arg His Lys Ala Tyr Leu 
1               5                   10                  15  


<210>  980
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  980

Ser Phe Tyr Asn Asn Leu Val Ser Phe Ala Ser Pro Leu Val Thr 
1               5                   10                  15  


<210>  981
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  981

Val Ala Gly Cys Tyr Leu Lys Tyr Lys Asn Lys Asn Ser Leu Ser 
1               5                   10                  15  


<210>  982
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  982

Ala Phe Met Tyr Ala Lys Lys Gly Glu Trp Lys Lys Ala Glu Glu 
1               5                   10                  15  


<210>  983
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  983

Ala Phe Thr Met Leu Leu Tyr Cys Glu Leu Leu Gln Trp Glu Asp 
1               5                   10                  15  


<210>  984
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  984

Ala Gly Gln Asn Pro Ala Ser Asp Pro Pro Pro Asp Asp Ala Glu 
1               5                   10                  15  


<210>  985
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  985

Ala Gly Arg Phe Gly Gln Gly Asp His His Ala Ala Gly Gln Ala 
1               5                   10                  15  


<210>  986
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  986

Ala Leu Lys Ile Lys Gly Ile Arg Pro Tyr His Ser Leu Ser Tyr 
1               5                   10                  15  


<210>  987
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  987

Ala Arg Val Ile Leu Gly Val Cys Trp Tyr Val Glu Thr Thr Ser 
1               5                   10                  15  


<210>  988
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  988

Ala Val Lys Arg Leu Pro Leu Ile Tyr Cys Asp Tyr His Gly His 
1               5                   10                  15  


<210>  989
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  989

Ala Val Val Phe Gln Asp Ser Met Val Phe Arg Val Ala Pro Trp 
1               5                   10                  15  


<210>  990
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  990

Ala Val Tyr Thr Pro Pro Ser Asp Ser Thr His Gln Met Pro Arg 
1               5                   10                  15  


<210>  991
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  991

Cys Asn Glu Cys Gly Lys Ala Leu Cys Gln Ser Pro Ser Leu Ile 
1               5                   10                  15  


<210>  992
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  992

Cys Asn Phe Ser Thr Ile Asp Val Ser Leu Lys Thr Asp Thr Glu 
1               5                   10                  15  


<210>  993
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  993

Cys Arg Gly Ser Gly Lys Ser Lys Val Gly Thr Ser Gly Asp His 
1               5                   10                  15  


<210>  994
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  994

Cys Val Ser Met Leu Gly Val Leu Val Asp Pro Asp Thr Leu His 
1               5                   10                  15  


<210>  995
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  995

Asp Glu Met Asp Cys Pro Leu Arg Pro Thr Pro Pro Leu Cys Ser 
1               5                   10                  15  


<210>  996
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  996

Asp Phe Gly Phe Ala Leu Thr Leu Ala Ala Pro Gly Asp Ile 
1               5                   10                  


<210>  997
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  997

Asp Pro Ser Ala Ile Gly Leu Val Asp Pro Pro Ile Pro Ser Pro 
1               5                   10                  15  


<210>  998
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  998

Glu Cys Gly Lys Ala Phe Asn Ser Ser Ser Asn Leu Thr Lys His 
1               5                   10                  15  


<210>  999
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  999

Glu Cys Gly Gln Ala Phe Ser Ile Ser Ser Asn Leu Met Arg His 
1               5                   10                  15  


<210>  1000
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1000

Glu Glu Cys Gly Lys Ala Phe Arg Val Phe Ser Thr Leu Thr Lys 
1               5                   10                  15  


<210>  1001
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1001

Glu Glu Cys Gly Lys Pro Phe Lys Arg Phe Ser Tyr Leu Thr Val 
1               5                   10                  15  


<210>  1002
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  1002

Glu Phe Pro Val Leu Gln Ala Ala Ala Ile Tyr Leu Lys 
1               5                   10              


<210>  1003
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1003

Glu His Ser Gln Glu Thr Glu Ile Leu Arg Glu Ala Leu Leu Ser 
1               5                   10                  15  


<210>  1004
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1004

Glu Lys Lys Gln Gln Phe Arg Ser Leu Lys Glu Lys Cys Phe Leu 
1               5                   10                  15  


<210>  1005
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1005

Glu Lys Pro Tyr Ser Cys Pro Glu Cys Ser Leu Arg Phe Ala Tyr 
1               5                   10                  15  


<210>  1006
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1006

Glu Pro Gly Asp Thr Ala Leu His Leu Cys Ala Ser Ser Gln Ser 
1               5                   10                  15  


<210>  1007
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1007

Phe Ala Ser Pro Gly Asp Asp Arg Asp Gly Arg Ala Glu Gly Phe 
1               5                   10                  15  


<210>  1008
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1008

Phe Glu Gly Thr Glu Met Trp Tyr Pro Asn Arg Glu Leu Ser Glu 
1               5                   10                  15  


<210>  1009
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1009

Phe Ser Ile Ser Gln Leu Gln Thr Asn His Asp Met Asn Asp Glu 
1               5                   10                  15  


<210>  1010
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  1010

Gly Ala Ile Val Ile Glu Leu Pro Asn Val Lys Trp Ser 
1               5                   10              


<210>  1011
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1011

Gly Cys Leu Gly Gly Glu Asn Cys Phe Arg Leu Arg Leu Glu Ser 
1               5                   10                  15  


<210>  1012
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1012

Gly Glu Pro Ile Pro Gln Pro Val Arg Leu Arg Tyr Val Thr Ser 
1               5                   10                  15  


<210>  1013
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  1013

Gly Leu Leu Arg Tyr Trp Arg Thr Glu Arg Leu Phe 
1               5                   10          


<210>  1014
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1014

Gly Leu Pro Thr Asp Thr Ile Cys Lys Glu Phe Arg Thr Arg Met 
1               5                   10                  15  


<210>  1015
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1015

Gly Arg Lys Phe Ala Ala Trp Gly Pro Pro Ser Phe Ser Gln Thr 
1               5                   10                  15  


<210>  1016
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1016

Gly Arg Leu Ile Leu Trp Glu Gly Pro Pro Leu Gly Ala Gly Gly 
1               5                   10                  15  


<210>  1017
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1017

Gly Arg Asn Ser Phe Glu Val Leu Val Cys Ala Cys Pro Gly Arg 
1               5                   10                  15  


<210>  1018
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1018

Gly Tyr Gly Glu Met Gly Ser Val Tyr Arg Glu Asp Leu Gly Ala 
1               5                   10                  15  


<210>  1019
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1019

His Gly Leu Ser His Ser Leu Trp Gln Ile Ser Ser Gln Leu Ser 
1               5                   10                  15  


<210>  1020
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1020

His Lys Arg Ile His Asn Gly Asp Lys Pro Tyr Lys Cys Glu Glu 
1               5                   10                  15  


<210>  1021
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1021

His Asn Asn Ile Val Tyr Asn Lys Tyr Ile Ser His Arg Glu His 
1               5                   10                  15  


<210>  1022
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1022

His Gln Arg Thr His Thr Gly Asp Lys Pro Phe Lys Cys Asp Glu 
1               5                   10                  15  


<210>  1023
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1023

Ile His Lys Met Ile His Thr Val Glu Lys Pro Tyr Lys Cys Glu 
1               5                   10                  15  


<210>  1024
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1024

Ile His Ser Ser Trp Asp Cys Ser Leu Phe Thr Asn Tyr Ser Ala 
1               5                   10                  15  


<210>  1025
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  1025

Ile Leu Phe Ser Leu Gln Pro Gly Leu Leu Arg Tyr Trp 
1               5                   10              


<210>  1026
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1026

Ile Leu Leu Ile His Cys Asp Thr His Leu His Thr Pro Met Tyr 
1               5                   10                  15  


<210>  1027
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1027

Ile Met Ala Ser Lys Gly Met His His Phe Cys Leu Ile Ser Glu 
1               5                   10                  15  


<210>  1028
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1028

Lys Ala Phe Ser Gln Ser Ser Ser Leu Arg Lys His Glu Ile Ile 
1               5                   10                  15  


<210>  1029
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1029

Lys Cys Asp Glu Cys Gly Asn Asp Phe Asn Trp Pro Ala Thr Leu 
1               5                   10                  15  


<210>  1030
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1030

Lys Cys Glu Glu Cys Asp Thr Asp Phe Ser Arg Lys Ser His His 
1               5                   10                  15  


<210>  1031
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1031

Lys Glu Leu Arg Ala Leu Arg Glu Met Val Ser Asn Met Ser Gly 
1               5                   10                  15  


<210>  1032
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  1032

Lys Leu Lys Lys Lys Gln Val Lys Val Phe Ala 
1               5                   10      


<210>  1033
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1033

Lys Leu Ser Val Ala Pro Ser Val Val Leu Glu Glu Asp Gln Val 
1               5                   10                  15  


<210>  1034
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1034

Lys Leu Val Val Val Gly Ala Val Gly Val Gly Lys Ser Ala Leu 
1               5                   10                  15  


<210>  1035
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1035

Lys Pro Val Ile Leu Gly Val Cys Trp Tyr Val Glu Thr Thr Ser 
1               5                   10                  15  


<210>  1036
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1036

Lys Ser Glu Gly Glu Glu Ala His Glu Val Glu Gly Glu Thr Gln 
1               5                   10                  15  


<210>  1037
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1037

Leu Ala Asp Gly Glu Gly Gly Ala Thr Asp Glu Gly Ile Tyr Asp 
1               5                   10                  15  


<210>  1038
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  1038

Leu Glu Leu Ile Asn Lys Leu Leu Ser Pro Val Val Pro Gln 
1               5                   10                  


<210>  1039
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1039

Leu Phe Gly Leu Gly Lys Asp Val Gly Trp Gly Pro Pro Ala Arg 
1               5                   10                  15  


<210>  1040
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1040

Leu Gly Leu Trp Arg Gly Glu Ala Val Thr Leu Ser Asn Pro Lys 
1               5                   10                  15  


<210>  1041
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1041

Leu Leu Asp Arg Gly Ser Phe Trp Asn Asp Gly Leu Lys Ala Ser 
1               5                   10                  15  


<210>  1042
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1042

Leu Leu Ile His Cys Asp Ala Tyr Leu His Thr Pro Met Tyr Phe 
1               5                   10                  15  


<210>  1043
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  1043

Leu Asn Lys Val Thr Ile Asp Ala Ile His Arg Leu Pro Leu 
1               5                   10                  


<210>  1044
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1044

Leu Gln Asn His Ile Gln Thr Phe His Arg Glu Leu Val Pro Asp 
1               5                   10                  15  


<210>  1045
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1045

Leu Arg Pro Gln Leu Ala Glu Lys Lys Gln Gln Phe Arg Asn Leu 
1               5                   10                  15  


<210>  1046
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1046

Leu Thr Asp His Arg Ala His Cys Cys Pro Gly Gly Asn Ala Lys 
1               5                   10                  15  


<210>  1047
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1047

Leu Trp His Leu Gln Gly Pro Glu Asp Leu Met Leu Lys Leu Arg 
1               5                   10                  15  


<210>  1048
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1048

Leu Trp Thr Glu Gly Met Leu Lys Met Ala Phe His Ile Leu Ala 
1               5                   10                  15  


<210>  1049
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1049

Met Asn Ala Ala Val Thr Phe Thr Asn Cys Ala Leu Gly Arg Val 
1               5                   10                  15  


<210>  1050
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  1050

Met Ser Tyr Asp Tyr His His Asn Trp Gly Arg Asp Gly Gly 
1               5                   10                  


<210>  1051
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1051

Asn Leu Val His Gly Pro Pro Gly Pro Pro Gln Val Gly Ala Asp 
1               5                   10                  15  


<210>  1052
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  1052

Asn Val Ser Phe Phe His Tyr Gln Glu Tyr Gly Tyr 
1               5                   10          


<210>  1053
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1053

Pro Phe Ser Pro Ser His Pro Gly Pro Pro Ser Asp Pro Ser His 
1               5                   10                  15  


<210>  1054
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1054

Pro Met Glu Lys Pro Thr Ile Thr Thr Glu Lys Pro Thr Ile Pro 
1               5                   10                  15  


<210>  1055
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1055

Pro Arg Cys Cys Ile Ser Ser Phe Cys Arg Pro Ser Cys Cys Val 
1               5                   10                  15  


<210>  1056
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1056

Pro Ser Arg His Arg Tyr Gly Thr Arg Gln Pro Arg Ala Arg Leu 
1               5                   10                  15  


<210>  1057
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1057

Pro Thr Lys Cys Glu Val Glu Gln Phe Thr Ala Thr Ser Phe Gly 
1               5                   10                  15  


<210>  1058
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1058

Pro Val Cys Ser Gly Ala Ser Ser Ser Cys Cys Gln Gln Ser Ser 
1               5                   10                  15  


<210>  1059
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1059

Pro Trp Arg Lys Phe Pro Val His Val Leu Gly Gln Phe Leu Gly 
1               5                   10                  15  


<210>  1060
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  1060

Gln Asp Leu Met Leu Glu Asp Asn Leu Leu Lys Leu Glu Val 
1               5                   10                  


<210>  1061
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1061

Gln Glu Val Glu Gly Glu Thr His Lys Thr Glu Gly Asp Ala Gln 
1               5                   10                  15  


<210>  1062
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1062

Gln Leu Leu Glu Gly Leu Gly Cys Thr Leu Thr Val Val Pro Glu 
1               5                   10                  15  


<210>  1063
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1063

Gln Leu Thr Ala His Lys Met Asn His Thr Gly Glu Lys Pro Tyr 
1               5                   10                  15  


<210>  1064
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1064

Arg Lys Phe Ile Ser Leu His Lys Lys Ala Leu Glu Ser Asp Phe 
1               5                   10                  15  


<210>  1065
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1065

Ser Gly Ser Gly Ser Gly Pro Phe Pro Ser Leu Phe Leu Asn Ser 
1               5                   10                  15  


<210>  1066
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1066

Ser His Asn Ser Ser Leu Ile Phe His Gln Arg Val His Thr Gly 
1               5                   10                  15  


<210>  1067
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1067

Ser Lys Met Gly Lys Trp Cys Ser His Cys Phe Ala Trp Cys Arg 
1               5                   10                  15  


<210>  1068
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1068

Ser Lys Met Gly Lys Trp Cys Ser His Cys Phe Pro Cys Cys Arg 
1               5                   10                  15  


<210>  1069
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1069

Ser Asn Asp Ser Ser Leu Thr His His Gln Arg Val His Thr Gly 
1               5                   10                  15  


<210>  1070
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1070

Ser Asn Leu Thr Lys His Lys Ile Ile His Ile Glu Lys Lys Pro 
1               5                   10                  15  


<210>  1071
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1071

Ser Asn Leu Thr Thr His Lys Ile Ile His Thr Gly Glu Arg Pro 
1               5                   10                  15  


<210>  1072
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1072

Ser Ser Gly Gly Gly Ser Ser Ser Gly Gly Tyr Gly Gly Gly Ser 
1               5                   10                  15  


<210>  1073
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1073

Ser Ser Leu Pro Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly Tyr 
1               5                   10                  15  


<210>  1074
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1074

Ser Thr Ala Tyr Pro Ala Pro Val Arg Arg Arg Cys Cys Leu Pro 
1               5                   10                  15  


<210>  1075
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1075

Ser Thr Leu Leu Thr Glu His Leu Arg Ile His Thr Gly Glu Lys 
1               5                   10                  15  


<210>  1076
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1076

Ser Thr Leu Asn Thr His Lys Ser Ile His Thr Gly Glu Glu Pro 
1               5                   10                  15  


<210>  1077
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1077

Thr Cys Cys Arg Thr Thr Cys Phe Arg Pro Ser Cys Cys Val Ser 
1               5                   10                  15  


<210>  1078
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1078

Thr Phe Asn Cys His His Ala Gln Pro Trp His Asn Gln Phe Val 
1               5                   10                  15  


<210>  1079
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1079

Thr Gly Ala Met Asn Val Ala Ile Gly Thr Ile Gln Thr Gly Val 
1               5                   10                  15  


<210>  1080
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1080

Thr His Arg Pro Gly Gly Lys Arg Gly Arg Leu Ala Gly Gly Ser 
1               5                   10                  15  


<210>  1081
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  1081

Thr Ile Tyr Ser Leu Phe Tyr Ser Val Ala Asp Gln Asp Ala Pro Ala 
1               5                   10                  15      


<210>  1082
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  1082

Thr Met Leu Ala Arg Leu Val Leu Asp Ser 
1               5                   10  


<210>  1083
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1083

Thr Gln Leu Arg Leu Pro Gly Trp Pro Thr Pro Val Ser Phe Gly 
1               5                   10                  15  


<210>  1084
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1084

Thr Arg Leu Phe Pro Asn Glu Leu Ala Asn Phe Tyr Asn Ala Val 
1               5                   10                  15  


<210>  1085
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1085

Thr Ser Cys Ala Arg Arg Asp Tyr Pro Arg Ala Ser Ser Pro Asn 
1               5                   10                  15  


<210>  1086
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1086

Val Met Met His Gly Gly Pro Ala His Pro Gly Met Pro Met Ser 
1               5                   10                  15  


<210>  1087
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1087

Val Asn Thr Thr Thr Ser Pro Ala Asn Thr Thr Thr Ser Pro Val 
1               5                   10                  15  


<210>  1088
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1088

Val Pro Val Ala Gln Val Thr Met Thr Ser Thr Thr Asp Ala Asp 
1               5                   10                  15  


<210>  1089
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1089

Val Gln Leu Arg Gly Arg Ala Leu Gly Gly Gly Ala Leu Arg Ala 
1               5                   10                  15  


<210>  1090
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1090

Val Arg Arg Cys Leu Pro Leu Trp Ala Leu Thr Leu Glu Ala Ala 
1               5                   10                  15  


<210>  1091
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1091

Val Thr Gly Gly Arg Gly Gly Trp Gln Gly Pro Ser Pro Ala Phe 
1               5                   10                  15  


<210>  1092
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1092

Val Thr Val His Pro Thr Ser Lys Ser Thr Ala Thr Ser Gln Gly 
1               5                   10                  15  


<210>  1093
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1093

Tyr Val Ser Met Met Cys Asn Lys Gln Ala Tyr Ser Leu Ala Val 
1               5                   10                  15  


<210>  1094
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  1094

Phe Tyr Gly Lys Thr Ile Leu Trp Phe 
1               5                   


<210>  1095
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  1095

Cys Leu Gly Gln Leu Ser Asn Ala 
1               5               


<210>  1096
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1096

Gly Asp Arg Phe Cys Leu Gly Gln Leu Ser Asn Ala His Arg Thr 
1               5                   10                  15  


<210>  1097
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  1097

Val Tyr Phe Phe Leu Pro Asp His Leu 
1               5                   


<210>  1098
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  1098

Ala Val Met Arg Trp Gly Met Pro Leu 
1               5                   


<210>  1099
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  1099

Lys Val Asp Pro Ile Gly His Val Tyr 
1               5                   


<210>  1100
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  1100

Val Met Leu Glu Gly Glu Gln Glu Ala 
1               5                   


<210>  1101
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  1101

Val Gln Leu Glu Glu Glu Tyr Glu Val 
1               5                   


<210>  1102
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  1102

Glu Thr Met Gln Cys Ser Glu Leu Tyr His Met 
1               5                   10      


<210>  1103
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  1103

Glu Val Ile Val Pro Leu Ser Gly Trp 
1               5                   


<210>  1104
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  1104

Glu Val Gln Gln Phe Leu Arg Tyr 
1               5               


<210>  1105
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  1105

Gln His Gln Pro Asn Pro Phe Glu Val 
1               5                   


<210>  1106
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1106

Glu Phe Glu Phe Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr Ser 
1               5                   10                  15  


<210>  1107
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1107

Arg Met Gln Ala Ala Ser Phe Gly Thr Phe Glu Gln Trp Val Val 
1               5                   10                  15  


<210>  1108
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1108

Ser Gly His Leu Leu Leu Gln Lys Leu Leu Arg Ala Lys Asn Val 
1               5                   10                  15  


<210>  1109
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  1109

Ala Ser Met Pro Ser Ser Pro Pro Leu 
1               5                   


<210>  1110
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  1110

Asp Tyr Met Ile His Ile Ile Glu Lys Trp 
1               5                   10  


<210>  1111
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  1111

Phe Ile Cys Ala Ile Ile Val Val Val 
1               5                   


<210>  1112
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  1112

Phe Leu Gly Ala Gly Leu Phe Leu Tyr Phe 
1               5                   10  


<210>  1113
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  1113

Gly Ala Gln Ser Trp Leu Trp Phe Val 
1               5                   


<210>  1114
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  1114

Gly Arg Lys Leu Phe Gly Thr His Phe 
1               5                   


<210>  1115
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  1115

Ile Pro Ile Asn Pro Arg Arg Cys Leu 
1               5                   


<210>  1116
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  1116

Lys Gln Trp Leu Val Trp Leu Phe Leu 
1               5                   


<210>  1117
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  1117

Leu Asp Tyr Glu Trp Gly Thr Val Thr Phe 
1               5                   10  


<210>  1118
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  1118

Arg Val Arg Val Met Ala Ile Tyr Lys 
1               5                   


<210>  1119
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  1119

Ser Ile Leu Glu Gln Met His Arg Lys 
1               5                   


<210>  1120
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  1120

Ser Met Ala Cys Val Gly Phe Phe Leu 
1               5                   


<210>  1121
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  1121

Thr Ser Asp Tyr Leu Ser Gln Ser Tyr 
1               5                   


<210>  1122
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  1122

Val Ala Asp Ile Asn Asp His Ala Leu 
1               5                   


<210>  1123
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  1123

Val Tyr Arg Pro Leu His Tyr Pro Leu Leu 
1               5                   10  


<210>  1124
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is g or absent

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is g or absent

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is g or absent

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is g or absent

<400>  1124
gnnnntccat gacgttcctg acgtt                                             25


<210>  1125
<211>  1210
<212>  PRT
<213>  Homo sapiens

<400>  1125

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210>  1126
<211>  724
<212>  PRT
<213>  Homo sapiens

<400>  1126

Met Ser Ala Glu Gly Tyr Gln Tyr Arg Ala Leu Tyr Asp Tyr Lys Lys 
1               5                   10                  15      


Glu Arg Glu Glu Asp Ile Asp Leu His Leu Gly Asp Ile Leu Thr Val 
            20                  25                  30          


Asn Lys Gly Ser Leu Val Ala Leu Gly Phe Ser Asp Gly Gln Glu Ala 
        35                  40                  45              


Arg Pro Glu Glu Ile Gly Trp Leu Asn Gly Tyr Asn Glu Thr Thr Gly 
    50                  55                  60                  


Glu Arg Gly Asp Phe Pro Gly Thr Tyr Val Glu Tyr Ile Gly Arg Lys 
65                  70                  75                  80  


Lys Ile Ser Pro Pro Thr Pro Lys Pro Arg Pro Pro Arg Pro Leu Pro 
                85                  90                  95      


Val Ala Pro Gly Ser Ser Lys Thr Glu Ala Asp Val Glu Gln Gln Ala 
            100                 105                 110         


Leu Thr Leu Pro Asp Leu Ala Glu Gln Phe Ala Pro Pro Asp Ile Ala 
        115                 120                 125             


Pro Pro Leu Leu Ile Lys Leu Val Glu Ala Ile Glu Lys Lys Gly Leu 
    130                 135                 140                 


Glu Cys Ser Thr Leu Tyr Arg Thr Gln Ser Ser Ser Asn Leu Ala Glu 
145                 150                 155                 160 


Leu Arg Gln Leu Leu Asp Cys Asp Thr Pro Ser Val Asp Leu Glu Met 
                165                 170                 175     


Ile Asp Val His Val Leu Ala Asp Ala Phe Lys Arg Tyr Leu Leu Asp 
            180                 185                 190         


Leu Pro Asn Pro Val Ile Pro Ala Ala Val Tyr Ser Glu Met Ile Ser 
        195                 200                 205             


Leu Ala Pro Glu Val Gln Ser Ser Glu Glu Tyr Ile Gln Leu Leu Lys 
    210                 215                 220                 


Lys Leu Ile Arg Ser Pro Ser Ile Pro His Gln Tyr Trp Leu Thr Leu 
225                 230                 235                 240 


Gln Tyr Leu Leu Lys His Phe Phe Lys Leu Ser Gln Thr Ser Ser Lys 
                245                 250                 255     


Asn Leu Leu Asn Ala Arg Val Leu Ser Glu Ile Phe Ser Pro Met Leu 
            260                 265                 270         


Phe Arg Phe Ser Ala Ala Ser Ser Asp Asn Thr Glu Asn Leu Ile Lys 
        275                 280                 285             


Val Ile Glu Ile Leu Ile Ser Thr Glu Trp Asn Glu Arg Gln Pro Ala 
    290                 295                 300                 


Pro Ala Leu Pro Pro Lys Pro Pro Lys Pro Thr Thr Val Ala Asn Asn 
305                 310                 315                 320 


Gly Met Asn Asn Asn Met Ser Leu Gln Asp Ala Glu Trp Tyr Trp Gly 
                325                 330                 335     


Asp Ile Ser Arg Glu Glu Val Asn Glu Lys Leu Arg Asp Thr Ala Asp 
            340                 345                 350         


Gly Thr Phe Leu Val Arg Asp Ala Ser Thr Lys Met His Gly Asp Tyr 
        355                 360                 365             


Thr Leu Thr Leu Arg Lys Gly Gly Asn Asn Lys Leu Ile Lys Ile Phe 
    370                 375                 380                 


His Arg Asp Gly Lys Tyr Gly Phe Ser Asp Pro Leu Thr Phe Ser Ser 
385                 390                 395                 400 


Val Val Glu Leu Ile Asn His Tyr Arg Asn Glu Ser Leu Ala Gln Tyr 
                405                 410                 415     


Asn Pro Lys Leu Asp Val Lys Leu Leu Tyr Pro Val Ser Lys Tyr Gln 
            420                 425                 430         


Gln Asp Gln Val Val Lys Glu Asp Asn Ile Glu Ala Val Gly Lys Lys 
        435                 440                 445             


Leu His Glu Tyr Asn Thr Gln Phe Gln Glu Lys Ser Arg Glu Tyr Asp 
    450                 455                 460                 


Arg Leu Tyr Glu Glu Tyr Thr Arg Thr Ser Gln Glu Ile Gln Met Lys 
465                 470                 475                 480 


Arg Thr Ala Ile Glu Ala Phe Asn Glu Thr Ile Lys Ile Phe Glu Glu 
                485                 490                 495     


Gln Cys Gln Thr Gln Glu Arg Tyr Ser Lys Glu Tyr Ile Glu Lys Phe 
            500                 505                 510         


Lys Arg Glu Gly Asn Glu Lys Glu Ile Gln Arg Ile Met His Asn Tyr 
        515                 520                 525             


Asp Lys Leu Lys Ser Arg Ile Ser Glu Ile Ile Asp Ser Arg Arg Arg 
    530                 535                 540                 


Leu Glu Glu Asp Leu Lys Lys Gln Ala Ala Glu Tyr Arg Glu Ile Asp 
545                 550                 555                 560 


Lys Arg Met Asn Ser Ile Lys Pro Asp Leu Ile Gln Leu Arg Lys Thr 
                565                 570                 575     


Arg Asp Gln Tyr Leu Met Trp Leu Thr Gln Lys Gly Val Arg Gln Lys 
            580                 585                 590         


Lys Leu Asn Glu Trp Leu Gly Asn Glu Asn Thr Glu Asp Gln Tyr Ser 
        595                 600                 605             


Leu Val Glu Asp Asp Glu Asp Leu Pro His His Asp Glu Lys Thr Trp 
    610                 615                 620                 


Asn Val Gly Ser Ser Asn Arg Asn Lys Ala Glu Asn Leu Leu Arg Gly 
625                 630                 635                 640 


Lys Arg Asp Gly Thr Phe Leu Val Arg Glu Ser Ser Lys Gln Gly Cys 
                645                 650                 655     


Tyr Ala Cys Ser Val Val Val Asp Gly Glu Val Lys His Cys Val Ile 
            660                 665                 670         


Asn Lys Thr Ala Thr Gly Tyr Gly Phe Ala Glu Pro Tyr Asn Leu Tyr 
        675                 680                 685             


Ser Ser Leu Lys Glu Leu Val Leu His Tyr Gln His Thr Ser Leu Val 
    690                 695                 700                 


Gln His Asn Asp Ser Leu Asn Val Thr Leu Ala Tyr Pro Val Tyr Ala 
705                 710                 715                 720 


Gln Gln Arg Arg 
                


<210>  1127
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  1127

Met Trp Asn Leu Leu His Glu Thr Asp Ser Ala Val Ala Thr Ala Arg 
1               5                   10                  15      


Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu Val Leu Ala Gly Gly Phe 
            20                  25                  30          


Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe Ile Lys Ser Ser Asn Glu 
        35                  40                  45              


Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu 
    50                  55                  60                  


Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln Ile 
65                  70                  75                  80  


Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile 
                85                  90                  95      


Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala His 
            100                 105                 110         


Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile 
        115                 120                 125             


Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe 
    130                 135                 140                 


Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro 
145                 150                 155                 160 


Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr 
                165                 170                 175     


Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met 
            180                 185                 190         


Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val 
        195                 200                 205             


Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys Gly 
    210                 215                 220                 


Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys 
225                 230                 235                 240 


Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly 
                245                 250                 255     


Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr 
            260                 265                 270         


Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val Gly 
        275                 280                 285             


Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln Lys 
    290                 295                 300                 


Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg 
305                 310                 315                 320 


Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn 
                325                 330                 335     


Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu Val 
            340                 345                 350         


Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro 
        355                 360                 365             


Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly 
    370                 375                 380                 


Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg 
385                 390                 395                 400 


Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile 
                405                 410                 415     


Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr 
            420                 425                 430         


Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala 
        435                 440                 445             


Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val 
    450                 455                 460                 


Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys Glu 
465                 470                 475                 480 


Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser 
                485                 490                 495     


Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile 
            500                 505                 510         


Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu 
        515                 520                 525             


Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn 
    530                 535                 540                 


Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu 
545                 550                 555                 560 


Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val 
                565                 570                 575     


Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val 
            580                 585                 590         


Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala 
        595                 600                 605             


Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys Thr 
    610                 615                 620                 


Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr 
625                 630                 635                 640 


Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser 
                645                 650                 655     


Asn Pro Ile Val Leu Arg Met Met Asn Asp Gln Leu Met Phe Leu Glu 
            660                 665                 670         


Arg Ala Phe Ile Asp Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr Arg 
        675                 680                 685             


His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu Ser 
    690                 695                 700                 


Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val Asp 
705                 710                 715                 720 


Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala Ala 
                725                 730                 735     


Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
            740                 745                 750 


<210>  1128
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  1128

Met Gly Pro Pro Ser Ala Ser Pro His Arg Glu Cys Ile Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Asn Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Ala Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Thr Asn Ala Ser Leu Leu Ile His Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Ile Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr 
    130                 135                 140     


<210>  1129
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  1129

Met Gly Leu Ser His Val Asp Gly Val Ser Thr Lys Thr Trp Ala Phe 
1               5                   10                  15      


Ser Ile Ala Cys Ala Phe Leu Ser Val Leu Asn Val Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Ala Asn Phe Pro Gly Leu Gly Phe Pro Cys Val Tyr Tyr His 
        35                  40                  45              


Ile Val Asp Tyr Gly Gln Phe Asn Met Thr Ala Phe Asn Val Leu His 
    50                  55                  60                  


Gln Ile Thr Pro Gln Leu Phe Leu Asp Ser Gly Gln Ile Val Ala Tyr 
65                  70                  75                  80  


Val Ala Phe Met Gln Phe Val Phe Ile Leu Val Thr Ile Tyr Tyr Val 
                85                  90                  95      


Val Cys Trp Ile Lys Ile Asn Phe Arg Lys Asp Gly Ser Ala Val Asn 
            100                 105                 110         


Gln Ala Thr Ile Asp Ile Gln Tyr Met Gly Asp Gly Leu Thr Cys Phe 
        115                 120                 125             


Leu Phe Ile Leu Thr Leu Asp Ser Phe Gln Leu Phe Ile Leu Ala Met 
    130                 135                 140                 


Ser Phe Arg Leu Pro Ala Ile Ile Ser Phe Thr Phe Ala Met His Phe 
145                 150                 155                 160 


Ile Ala Leu Thr Ala Phe Val Val Thr Leu Ile Thr Gln Tyr Gln Ser 
                165                 170                 175     


Phe Asp Arg Ser Thr Phe Met Leu Asn Lys Leu His Pro Lys Leu Arg 
            180                 185                 190         


Gly Thr Val Lys Phe Lys Thr Ala Val Val Asn Leu Leu Gln Met Ala 
        195                 200                 205             


Met Gly Phe Ser Thr Met Val Leu Ser Met Thr Leu Cys Leu Gly Phe 
    210                 215                 220                 


Gly Asn Ser Phe Leu Val Arg Thr Ser His Met Val Phe Ser Thr Ile 
225                 230                 235                 240 


Ile Val Phe Thr Leu Leu Ala Cys Ile Tyr Leu Ile Val Leu Glu Thr 
                245                 250                 255     


Val Leu Ile Arg Tyr Met Lys Val Gln Phe Gly Tyr His Phe Gly Ala 
            260                 265                 270         


Phe Cys Gly Met Cys Gly Ala Leu Tyr Pro Ile Ile Lys Tyr Glu Ala 
        275                 280                 285             


Ile Thr His His Glu His Glu Thr Thr Val Tyr Val Leu Val Gly Leu 
    290                 295                 300                 


Met Phe Leu Ser Trp Leu Thr Leu Thr Leu Cys Arg Ile Ile Arg Phe 
305                 310                 315                 320 


Phe Ile Leu Arg His Arg Pro Ser Tyr Lys Pro Leu Pro Asp Pro Ser 
                325                 330                 335     


Glu Val Lys Pro Leu Ser Ser Lys Leu Asp Ile Asp Glu 
            340                 345                 


<210>  1130
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  1130

Met Ala Ser Leu Gln Met Arg Gly Asn Pro Gly Ser His Phe Cys Gly 
1               5                   10                  15      


Gly Thr Leu Ile His Pro Ser Phe Val Leu Thr Ala Ala His Cys Leu 
            20                  25                  30          


Arg Asp Ile Pro Gln Arg Leu Val Asn Val Val Leu Gly Ala His Asn 
        35                  40                  45              


Val Arg Thr Gln Glu Pro Thr Gln Gln His Phe Ser Val Ala Gln Val 
    50                  55                  60                  


Phe Leu Asn Asn Tyr Asp Ala Glu Asn Lys Leu Asn Asp Ile Leu Leu 
65                  70                  75                  80  


Ile Gln Leu Ser Ser Pro Ala Asn Leu Ser Ala Ser Val Ala Thr Val 
                85                  90                  95      


Gln Leu Pro Gln Gln Asp Gln Pro Val Pro His Gly Thr Gln Cys Leu 
            100                 105                 110         


Ala Met Gly Trp Gly Arg Val Gly Ala His Asp Pro Pro Ala Gln Val 
        115                 120                 125             


Leu Gln Glu Leu Asn Val Thr Val Val Thr Phe Phe Cys Arg Pro His 
    130                 135                 140                 


Asn Ile Cys Thr Phe Val Pro Arg Arg Lys Ala Gly Ile Cys Phe Gly 
145                 150                 155                 160 


Asp Ser Gly Gly Pro Leu Ile Cys Asp Gly Ile Ile Gln Gly Ile Asp 
                165                 170                 175     


Ser Phe Val Ile Trp Gly Cys Ala Thr Arg Leu Phe Pro Asp Phe Phe 
            180                 185                 190         


Thr Arg Val Ala Leu Tyr Val Asp Trp Ile Arg Ser Thr Leu Arg Arg 
        195                 200                 205             


Val Glu Ala Lys Gly Arg Pro 
    210                 215 


<210>  1131
<211>  1644
<212>  PRT
<213>  Homo sapiens

<400>  1131

Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 
1               5                   10                  15      


Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 
            20                  25                  30          


Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 
        35                  40                  45              


Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Thr Leu Leu Ala 
    50                  55                  60                  


Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 
65                  70                  75                  80  


Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 
                85                  90                  95      


Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 
            100                 105                 110         


Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 
        115                 120                 125             


Gly Thr Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 
    130                 135                 140                 


Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 
145                 150                 155                 160 


Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 
                165                 170                 175     


Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 
            180                 185                 190         


Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 
        195                 200                 205             


Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 
    210                 215                 220                 


Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 
225                 230                 235                 240 


Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 
                245                 250                 255     


Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 
            260                 265                 270         


Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Met Met 
        275                 280                 285             


Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Thr Ser Glu 
    290                 295                 300                 


Gln Glu Lys Arg Leu Thr Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 
305                 310                 315                 320 


Phe Glu Asp Cys Gly Gly Gly Tyr Thr Pro Asp Cys Ser Ser Asn Glu 
                325                 330                 335     


Asn Leu Thr Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 
            340                 345                 350         


Val Ser Pro Ser Pro Thr Thr Tyr Arg Met Phe Arg Asp Lys Ser Arg 
        355                 360                 365             


Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 
    370                 375                 380                 


Thr Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 
385                 390                 395                 400 


Glu Ala Thr Ile Val Gly Val Arg Lys Thr Gly Gln Ile Trp Pro Asn 
                405                 410                 415     


Asp Gly Glu Gly Ala Phe His Gly Asp Ala Asp Gly Ser Phe Gly Thr 
            420                 425                 430         


Pro Pro Gly Tyr Gly Cys Ala Ala Asp Arg Ala Glu Glu Gln Arg Arg 
        435                 440                 445             


His Gln Asp Gly Leu Pro Tyr Ile Asp Asp Ser Pro Ser Ser Ser Pro 
    450                 455                 460                 


His Leu Ser Ser Lys Gly Arg Gly Ser Arg Asp Ala Leu Val Ser Gly 
465                 470                 475                 480 


Ala Leu Glu Ser Thr Lys Ala Ser Glu Leu Asp Leu Glu Lys Gly Leu 
                485                 490                 495     


Glu Met Arg Lys Trp Val Leu Ser Gly Ile Leu Ala Ser Glu Glu Thr 
            500                 505                 510         


Tyr Leu Ser His Leu Gln Met Leu Thr Asn Ser Cys Val Lys Leu Gln 
        515                 520                 525             


Thr Val His Ser Ile Pro Leu Thr Ile Asn Lys Glu Glu Ala Leu Gln 
    530                 535                 540                 


Arg Pro Val Ala Ser Asp Phe Glu Pro Gln Gly Leu Ser Glu Ala Ala 
545                 550                 555                 560 


Arg Trp Asn Ser Lys Glu Asn Leu Leu Ala Gly Pro Ser Glu Asn Asp 
                565                 570                 575     


Pro Asn Leu Phe Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn 
            580                 585                 590         


Thr Leu Ser Ile Thr Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn 
        595                 600                 605             


His Asn Gly Glu Trp Cys Glu Ala Gln Thr Lys Asn Gly Gln Gly Trp 
    610                 615                 620                 


Val Pro Ser Asn Tyr Ile Thr Pro Val Asn Ser Leu Glu Lys His Ser 
625                 630                 635                 640 


Trp Tyr His Gly Pro Val Ser Arg Asn Ala Ala Glu Tyr Leu Leu Ser 
                645                 650                 655     


Ser Gly Ile Asn Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro 
            660                 665                 670         


Gly Gln Arg Ser Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr 
        675                 680                 685             


Arg Ile Asn Thr Ala Ser Asp Gly Lys Leu Tyr Val Ser Ser Glu Ser 
    690                 695                 700                 


Arg Phe Asn Thr Leu Ala Glu Leu Val His His His Ser Thr Val Ala 
705                 710                 715                 720 


Asp Gly Leu Ile Thr Thr Leu His Tyr Pro Ala Pro Lys Arg Asn Lys 
                725                 730                 735     


Pro Thr Val Tyr Gly Val Ser Pro Asn Tyr Asp Lys Trp Glu Met Glu 
            740                 745                 750         


Arg Thr Asp Ile Thr Met Lys His Lys Leu Gly Gly Gly Gln Tyr Gly 
        755                 760                 765             


Glu Val Tyr Glu Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala Val 
    770                 775                 780                 


Lys Thr Leu Lys Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys Glu 
785                 790                 795                 800 


Ala Ala Val Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu 
                805                 810                 815     


Gly Val Cys Thr Arg Glu Pro Pro Phe Tyr Ile Ile Thr Glu Phe Met 
            820                 825                 830         


Thr Tyr Gly Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Gln Glu 
        835                 840                 845             


Val Asn Ala Val Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala 
    850                 855                 860                 


Met Glu Tyr Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala 
865                 870                 875                 880 


Arg Asn Cys Leu Val Gly Glu Asn His Leu Val Lys Val Ala Asp Phe 
                885                 890                 895     


Gly Leu Ser Arg Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala Gly 
            900                 905                 910         


Ala Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn 
        915                 920                 925             


Lys Phe Ser Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp 
    930                 935                 940                 


Glu Ile Ala Thr Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu Ser 
945                 950                 955                 960 


Gln Val Tyr Glu Leu Leu Glu Lys Asp Tyr Arg Met Glu Arg Pro Glu 
                965                 970                 975     


Gly Cys Pro Glu Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Gln Trp 
            980                 985                 990         


Asn Pro Ser Asp Arg Pro Ser Phe  Ala Glu Ile His Gln  Ala Phe Glu 
        995                 1000                 1005             


Thr Met  Phe Gln Glu Ser Ser  Ile Ser Asp Glu Val  Glu Lys Glu 
    1010                 1015                 1020             


Leu Gly  Lys Gln Gly Val Arg  Gly Ala Val Ser Thr  Leu Leu Gln 
    1025                 1030                 1035             


Ala Pro  Glu Leu Pro Thr Lys  Thr Arg Thr Ser Arg  Arg Ala Ala 
    1040                 1045                 1050             


Glu His  Arg Asp Thr Thr Asp  Val Pro Glu Met Pro  His Ser Lys 
    1055                 1060                 1065             


Gly Gln  Gly Glu Ser Asp Pro  Leu Asp His Glu Pro  Ala Val Ser 
    1070                 1075                 1080             


Pro Leu  Leu Pro Arg Lys Glu  Arg Gly Pro Pro Glu  Gly Gly Leu 
    1085                 1090                 1095             


Asn Glu  Asp Glu Arg Leu Leu  Pro Lys Asp Lys Lys  Thr Asn Leu 
    1100                 1105                 1110             


Phe Ser  Ala Leu Ile Lys Lys  Lys Lys Lys Thr Ala  Pro Thr Pro 
    1115                 1120                 1125             


Pro Lys  Arg Ser Ser Ser Phe  Arg Glu Met Asp Gly  Gln Pro Glu 
    1130                 1135                 1140             


Arg Arg  Gly Ala Gly Glu Glu  Glu Gly Arg Asp Ile  Ser Asn Gly 
    1145                 1150                 1155             


Ala Leu  Ala Phe Thr Pro Leu  Asp Thr Ala Asp Pro  Ala Lys Ser 
    1160                 1165                 1170             


Pro Lys  Pro Ser Asn Gly Ala  Gly Val Pro Asn Gly  Ala Leu Arg 
    1175                 1180                 1185             


Glu Ser  Gly Gly Ser Gly Phe  Arg Ser Pro His Leu  Trp Lys Lys 
    1190                 1195                 1200             


Ser Ser  Thr Leu Thr Ser Ser  Arg Leu Ala Thr Gly  Glu Glu Glu 
    1205                 1210                 1215             


Gly Gly  Gly Ser Ser Ser Lys  Arg Phe Leu Arg Ser  Cys Ser Ala 
    1220                 1225                 1230             


Ser Cys  Val Pro His Gly Ala  Lys Asp Thr Glu Trp  Arg Ser Val 
    1235                 1240                 1245             


Thr Leu  Pro Arg Asp Leu Gln  Ser Thr Gly Arg Gln  Phe Asp Ser 
    1250                 1255                 1260             


Ser Thr  Phe Gly Gly His Lys  Ser Glu Lys Pro Ala  Leu Pro Arg 
    1265                 1270                 1275             


Lys Arg  Ala Gly Glu Asn Arg  Ser Asp Gln Val Thr  Arg Gly Thr 
    1280                 1285                 1290             


Val Thr  Pro Pro Pro Arg Leu  Val Lys Lys Asn Glu  Glu Ala Ala 
    1295                 1300                 1305             


Asp Glu  Val Phe Lys Asp Ile  Met Glu Ser Ser Pro  Gly Ser Ser 
    1310                 1315                 1320             


Pro Pro  Asn Leu Thr Pro Lys  Pro Leu Arg Arg Gln  Val Thr Val 
    1325                 1330                 1335             


Ala Pro  Ala Ser Gly Leu Pro  His Lys Glu Glu Ala  Gly Lys Gly 
    1340                 1345                 1350             


Ser Ala  Leu Gly Thr Pro Ala  Ala Ala Glu Pro Val  Thr Pro Thr 
    1355                 1360                 1365             


Ser Lys  Ala Gly Ser Gly Ala  Pro Gly Gly Thr Ser  Lys Gly Pro 
    1370                 1375                 1380             


Ala Glu  Glu Ser Arg Val Arg  Arg His Lys His Ser  Ser Glu Ser 
    1385                 1390                 1395             


Pro Gly  Arg Asp Lys Gly Lys  Leu Ser Arg Leu Lys  Pro Ala Pro 
    1400                 1405                 1410             


Pro Pro  Pro Pro Ala Ala Ser  Ala Gly Lys Ala Gly  Gly Lys Pro 
    1415                 1420                 1425             


Ser Gln  Ser Pro Ser Gln Glu  Ala Ala Gly Glu Ala  Val Leu Gly 
    1430                 1435                 1440             


Ala Lys  Thr Lys Ala Thr Ser  Leu Val Asp Ala Val  Asn Ser Asp 
    1445                 1450                 1455             


Ala Ala  Lys Pro Ser Gln Pro  Gly Glu Gly Leu Lys  Lys Pro Val 
    1460                 1465                 1470             


Leu Pro  Ala Thr Pro Lys Pro  Gln Ser Ala Lys Pro  Ser Gly Thr 
    1475                 1480                 1485             


Pro Ile  Ser Pro Ala Pro Val  Pro Ser Thr Leu Pro  Ser Ala Ser 
    1490                 1495                 1500             


Ser Ala  Leu Ala Gly Asp Gln  Pro Ser Ser Thr Ala  Phe Ile Pro 
    1505                 1510                 1515             


Leu Ile  Ser Thr Arg Val Ser  Leu Arg Lys Thr Arg  Gln Pro Pro 
    1520                 1525                 1530             


Glu Arg  Ile Ala Ser Gly Ala  Ile Thr Lys Gly Val  Val Leu Asp 
    1535                 1540                 1545             


Ser Thr  Glu Ala Leu Cys Leu  Ala Ile Ser Arg Asn  Ser Glu Gln 
    1550                 1555                 1560             


Met Ala  Ser His Ser Ala Val  Leu Glu Ala Gly Lys  Asn Leu Tyr 
    1565                 1570                 1575             


Thr Phe  Cys Val Ser Tyr Val  Asp Ser Ile Gln Gln  Met Arg Asn 
    1580                 1585                 1590             


Lys Phe  Ala Phe Arg Glu Ala  Ile Asn Lys Leu Glu  Asn Asn Leu 
    1595                 1600                 1605             


Arg Glu  Leu Gln Ile Cys Pro  Ala Thr Ala Gly Ser  Gly Pro Ala 
    1610                 1615                 1620             


Ala Thr  Gln Asp Phe Ser Lys  Leu Leu Ser Ser Val  Lys Glu Ile 
    1625                 1630                 1635             


Ser Asp  Ile Val Gln Arg 
    1640                 


<210>  1132
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  1132

Met Gly Ala Pro Thr Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp 
1               5                   10                  15      


His Arg Ile Ser Thr Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala 
            20                  25                  30          


Cys Thr Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Thr 
        35                  40                  45              


Glu Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu 
    50                  55                  60                  


Glu Gly Trp Glu Pro Asp Asp Asp Pro Ile Glu Glu His Lys Lys His 
65                  70                  75                  80  


Ser Ser Gly Cys Ala Phe Leu Ser Val Lys Lys Gln Phe Glu Glu Leu 
                85                  90                  95      


Thr Leu Gly Glu Phe Leu Lys Leu Asp Arg Glu Arg Ala Lys Asn Lys 
            100                 105                 110         


Ile Ala Lys Glu Thr Asn Asn Lys Lys Lys Glu Phe Glu Glu Thr Ala 
        115                 120                 125             


Lys Lys Val Arg Arg Ala Ile Glu Gln Leu Ala Ala Met Asp 
    130                 135                 140         


<210>  1133
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  1133

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu 
65                  70                  75                  80  


Phe His Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asp Met Ser Leu Leu Lys Asn Arg Phe Leu Arg 
            100                 105                 110         


Pro Gly Asp Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu 
        115                 120                 125             


Pro Ala Glu Leu Thr Asp Ala Val Lys Val Met Asp Leu Pro Thr Gln 
    130                 135                 140                 


Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Glu Phe Leu Thr Pro Lys Lys Leu Gln Cys Val Asp Leu 
                165                 170                 175     


His Val Ile Ser Asn Asp Val Cys Ala Gln Val His Pro Gln Lys Val 
            180                 185                 190         


Thr Lys Phe Met Leu Cys Ala Gly Arg Trp Thr Gly Gly Lys Ser Thr 
        195                 200                 205             


Cys Ser Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Gly Val Leu Gln 
    210                 215                 220                 


Gly Ile Thr Ser Trp Gly Ser Glu Pro Cys Ala Leu Pro Glu Arg Pro 
225                 230                 235                 240 


Ser Leu Tyr Thr Lys Val Val His Tyr Arg Lys Trp Ile Lys Asp Thr 
                245                 250                 255     


Ile Val Ala Asn Pro 
            260     


<210>  1134
<211>  1072
<212>  PRT
<213>  Homo sapiens

<400>  1134

Asp Ala Arg Pro Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys 
1               5                   10                  15      


Leu Lys Glu Leu Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly 
            20                  25                  30          


Ala Lys Asn Val Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg 
        35                  40                  45              


Gly Gly Pro Pro Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro 
    50                  55                  60                  


Asn Thr Val Thr Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu 
65                  70                  75                  80  


Leu Arg Arg Val Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys 
                85                  90                  95      


Ala Leu Phe Val Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly 
            100                 105                 110         


Pro Pro Leu Tyr Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro 
        115                 120                 125             


His Ala Ser Gly Pro Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn 
    130                 135                 140                 


His Ser Val Arg Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly 
145                 150                 155                 160 


Ala Arg Arg Arg Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys 
                165                 170                 175     


Arg Pro Arg Arg Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly 
            180                 185                 190         


Gln Gly Ser Trp Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg 
        195                 200                 205             


Gly Phe Cys Val Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser 
    210                 215                 220                 


Leu Glu Gly Ala Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly 
225                 230                 235                 240 


Arg Gln His His Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro 
                245                 250                 255     


Trp Asp Thr Pro Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu 
            260                 265                 270         


Tyr Ser Ser Gly Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser 
        275                 280                 285             


Ser Leu Arg Pro Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile 
    290                 295                 300                 


Phe Leu Gly Ser Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro 
305                 310                 315                 320 


Arg Leu Pro Gln Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu 
                325                 330                 335     


Leu Gly Asn His Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His 
            340                 345                 350         


Cys Pro Leu Arg Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg 
        355                 360                 365             


Glu Lys Pro Gln Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp 
    370                 375                 380                 


Pro Arg Arg Leu Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln 
385                 390                 395                 400 


Val Tyr Gly Phe Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly 
                405                 410                 415     


Leu Trp Gly Ser Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys 
            420                 425                 430         


Lys Phe Ile Ser Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu 
        435                 440                 445             


Thr Trp Lys Met Ser Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro 
    450                 455                 460                 


Gly Val Gly Cys Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile 
465                 470                 475                 480 


Leu Ala Lys Phe Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu 
                485                 490                 495     


Leu Arg Ser Phe Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Arg 
            500                 505                 510         


Leu Phe Phe Tyr Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly 
        515                 520                 525             


Ile Arg Gln His Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala 
    530                 535                 540                 


Glu Val Arg Gln His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg 
545                 550                 555                 560 


Leu Arg Phe Ile Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met 
                565                 570                 575     


Asp Tyr Val Val Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu 
            580                 585                 590         


Arg Leu Thr Ser Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu 
        595                 600                 605             


Arg Ala Arg Arg Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp 
    610                 615                 620                 


Asp Ile His Arg Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln 
625                 630                 635                 640 


Asp Pro Pro Pro Glu Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala 
                645                 650                 655     


Tyr Asp Thr Ile Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile 
            660                 665                 670         


Ile Lys Pro Gln Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln 
        675                 680                 685             


Lys Ala Ala His Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser 
    690                 695                 700                 


Thr Leu Thr Asp Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu 
705                 710                 715                 720 


Gln Glu Thr Ser Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser 
                725                 730                 735     


Ser Leu Asn Glu Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe 
            740                 745                 750         


Met Cys His His Ala Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys 
        755                 760                 765             


Gln Gly Ile Pro Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu 
    770                 775                 780                 


Cys Tyr Gly Asp Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp 
785                 790                 795                 800 


Gly Leu Leu Leu Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His 
                805                 810                 815     


Leu Thr His Ala Lys Thr Phe Leu Arg Thr Leu Val Arg Gly Val Pro 
            820                 825                 830         


Glu Tyr Gly Cys Val Val Asn Leu Arg Lys Thr Val Val Asn Phe Pro 
        835                 840                 845             


Val Glu Asp Glu Ala Leu Gly Gly Thr Ala Phe Val Gln Met Pro Ala 
    850                 855                 860                 


His Gly Leu Phe Pro Trp Cys Gly Leu Leu Leu Asp Thr Arg Thr Leu 
865                 870                 875                 880 


Glu Val Gln Ser Asp Tyr Ser Ser Tyr Ala Arg Thr Ser Ile Arg Ala 
                885                 890                 895     


Ser Leu Thr Phe Asn Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg 
            900                 905                 910         


Lys Leu Phe Gly Val Leu Arg Leu Lys Cys His Ser Leu Phe Leu Asp 
        915                 920                 925             


Leu Gln Val Asn Ser Leu Gln Thr Val Cys Thr Asn Ile Tyr Lys Ile 
    930                 935                 940                 


Leu Leu Leu Gln Ala Tyr Arg Phe His Ala Cys Val Leu Gln Leu Pro 
945                 950                 955                 960 


Phe His Gln Gln Val Trp Lys Asn Pro Thr Phe Phe Leu Arg Val Ile 
                965                 970                 975     


Ser Asp Thr Ala Ser Leu Cys Tyr Ser Ile Leu Lys Ala Lys Asn Ala 
            980                 985                 990         


Gly Met Ser Leu Gly Ala Lys Gly  Ala Ala Gly Pro Leu  Pro Ser Glu 
        995                 1000                 1005             


Ala Val  Gln Trp Leu Cys His  Gln Ala Phe Leu Leu  Lys Leu Thr 
    1010                 1015                 1020             


Arg His  Arg Val Thr Tyr Val  Pro Leu Leu Gly Ser  Leu Arg Thr 
    1025                 1030                 1035             


Ala Gln  Thr Gln Leu Ser Arg  Lys Leu Pro Gly Thr  Thr Leu Thr 
    1040                 1045                 1050             


Ala Leu  Glu Ala Ala Ala Asn  Pro Ala Leu Pro Ser  Asp Phe Lys 
    1055                 1060                 1065             


Thr Ile  Leu Asp 
    1070         


<210>  1135
<211>  976
<212>  PRT
<213>  Homo sapiens

<400>  1135

Met Glu Leu Gln Ala Ala Arg Ala Cys Phe Ala Leu Leu Trp Gly Cys 
1               5                   10                  15      


Ala Leu Ala Ala Ala Ala Ala Ala Gln Gly Lys Glu Val Val Leu Leu 
            20                  25                  30          


Asp Phe Ala Ala Ala Gly Gly Glu Leu Gly Trp Leu Thr His Pro Tyr 
        35                  40                  45              


Gly Lys Gly Trp Asp Leu Met Gln Asn Ile Met Asn Asp Met Pro Ile 
    50                  55                  60                  


Tyr Met Tyr Ser Val Cys Asn Val Met Ser Gly Asp Gln Asp Asn Trp 
65                  70                  75                  80  


Leu Arg Thr Asn Trp Val Tyr Arg Gly Glu Ala Glu Arg Ile Phe Ile 
                85                  90                  95      


Glu Leu Lys Phe Thr Val Arg Asp Cys Asn Ser Phe Pro Gly Gly Ala 
            100                 105                 110         


Ser Ser Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Ala Glu Ser Asp Leu 
        115                 120                 125             


Asp Tyr Gly Thr Asn Phe Gln Lys Arg Leu Phe Thr Lys Ile Asp Thr 
    130                 135                 140                 


Ile Ala Pro Asp Glu Ile Thr Val Ser Ser Asp Phe Glu Ala Arg His 
145                 150                 155                 160 


Val Lys Leu Asn Val Glu Glu Arg Ser Val Gly Pro Leu Thr Arg Lys 
                165                 170                 175     


Gly Phe Tyr Leu Ala Phe Gln Asp Ile Gly Ala Cys Val Ala Leu Leu 
            180                 185                 190         


Ser Val Arg Val Tyr Tyr Lys Lys Cys Pro Glu Leu Leu Gln Gly Leu 
        195                 200                 205             


Ala His Phe Pro Glu Thr Ile Ala Gly Ser Asp Ala Pro Ser Leu Ala 
    210                 215                 220                 


Thr Val Ala Gly Thr Cys Val Asp His Ala Val Val Pro Pro Gly Gly 
225                 230                 235                 240 


Glu Glu Pro Arg Met His Cys Ala Val Asp Gly Glu Trp Leu Val Pro 
                245                 250                 255     


Ile Gly Gln Cys Leu Cys Gln Ala Gly Tyr Glu Lys Val Glu Asp Ala 
            260                 265                 270         


Cys Gln Ala Cys Ser Pro Gly Phe Phe Lys Phe Glu Ala Ser Glu Ser 
        275                 280                 285             


Pro Cys Leu Glu Cys Pro Glu His Thr Leu Pro Ser Pro Glu Gly Ala 
    290                 295                 300                 


Thr Ser Cys Glu Cys Glu Glu Gly Phe Phe Arg Ala Pro Gln Asp Pro 
305                 310                 315                 320 


Ala Ser Met Pro Cys Thr Arg Pro Pro Ser Ala Pro His Tyr Leu Thr 
                325                 330                 335     


Ala Val Gly Met Gly Ala Lys Val Glu Leu Arg Trp Thr Pro Pro Gln 
            340                 345                 350         


Asp Ser Gly Gly Arg Glu Asp Ile Val Tyr Ser Val Thr Cys Glu Gln 
        355                 360                 365             


Cys Trp Pro Glu Ser Gly Glu Cys Gly Pro Cys Glu Ala Ser Val Arg 
    370                 375                 380                 


Tyr Ser Glu Pro Pro His Gly Leu Thr Arg Thr Ser Val Thr Val Ser 
385                 390                 395                 400 


Asp Leu Glu Pro His Met Asn Tyr Thr Phe Thr Val Glu Ala Arg Asn 
                405                 410                 415     


Gly Val Ser Gly Leu Val Thr Ser Arg Ser Phe Arg Thr Ala Ser Val 
            420                 425                 430         


Ser Ile Asn Gln Thr Glu Pro Pro Lys Val Arg Leu Glu Gly Arg Ser 
        435                 440                 445             


Thr Thr Ser Leu Ser Val Ser Trp Ser Ile Pro Pro Pro Gln Gln Ser 
    450                 455                 460                 


Arg Val Trp Lys Tyr Glu Val Thr Tyr Arg Lys Lys Gly Asp Ser Asn 
465                 470                 475                 480 


Ser Tyr Asn Val Arg Arg Thr Glu Gly Phe Ser Val Thr Leu Asp Asp 
                485                 490                 495     


Leu Ala Pro Asp Thr Thr Tyr Leu Val Gln Val Gln Ala Leu Thr Gln 
            500                 505                 510         


Glu Gly Gln Gly Ala Gly Ser Lys Val His Glu Phe Gln Thr Leu Ser 
        515                 520                 525             


Pro Glu Gly Ser Gly Asn Leu Ala Val Ile Gly Gly Val Ala Val Gly 
    530                 535                 540                 


Val Val Leu Leu Leu Val Leu Ala Gly Val Gly Phe Phe Ile His Arg 
545                 550                 555                 560 


Arg Arg Lys Asn Gln Arg Ala Arg Gln Ser Pro Glu Asp Val Tyr Phe 
                565                 570                 575     


Ser Lys Ser Glu Gln Leu Lys Pro Leu Lys Thr Tyr Val Asp Pro His 
            580                 585                 590         


Thr Tyr Glu Asp Pro Asn Gln Ala Val Leu Lys Phe Thr Thr Glu Ile 
        595                 600                 605             


His Pro Ser Cys Val Thr Arg Gln Lys Val Ile Gly Ala Gly Glu Phe 
    610                 615                 620                 


Gly Glu Val Tyr Lys Gly Met Leu Lys Thr Ser Ser Gly Lys Lys Glu 
625                 630                 635                 640 


Val Pro Val Ala Ile Lys Thr Leu Lys Ala Gly Tyr Thr Glu Lys Gln 
                645                 650                 655     


Arg Val Asp Phe Leu Gly Glu Ala Gly Ile Met Gly Gln Phe Ser His 
            660                 665                 670         


His Asn Ile Ile Arg Leu Glu Gly Val Ile Ser Lys Tyr Lys Pro Met 
        675                 680                 685             


Met Ile Ile Thr Glu Tyr Met Glu Asn Gly Ala Leu Asp Lys Phe Leu 
    690                 695                 700                 


Arg Glu Lys Asp Gly Glu Phe Ser Val Leu Gln Leu Val Gly Met Leu 
705                 710                 715                 720 


Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ala Asn Met Asn Tyr Val 
                725                 730                 735     


His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser Asn Leu Val 
            740                 745                 750         


Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Val Leu Glu Asp Asp Pro 
        755                 760                 765             


Glu Ala Thr Tyr Thr Thr Ser Gly Gly Lys Ile Pro Ile Arg Trp Thr 
    770                 775                 780                 


Ala Pro Glu Ala Ile Ser Tyr Arg Lys Phe Thr Ser Ala Ser Asp Val 
785                 790                 795                 800 


Trp Ser Phe Gly Ile Val Met Trp Glu Val Met Thr Tyr Gly Glu Arg 
                805                 810                 815     


Pro Tyr Trp Glu Leu Ser Asn His Glu Val Met Lys Ala Ile Asn Asp 
            820                 825                 830         


Gly Phe Arg Leu Pro Thr Pro Met Asp Cys Pro Ser Ala Ile Tyr Gln 
        835                 840                 845             


Leu Met Met Gln Cys Trp Gln Gln Glu Arg Ala Arg Arg Pro Lys Phe 
    850                 855                 860                 


Ala Asp Ile Val Ser Ile Leu Asp Lys Leu Ile Arg Ala Pro Asp Ser 
865                 870                 875                 880 


Leu Lys Thr Leu Ala Asp Phe Asp Pro Arg Val Ser Ile Arg Leu Pro 
                885                 890                 895     


Ser Thr Ser Gly Ser Glu Gly Val Pro Phe Arg Thr Val Ser Glu Trp 
            900                 905                 910         


Leu Glu Ser Ile Lys Met Gln Gln Tyr Thr Glu His Phe Met Ala Ala 
        915                 920                 925             


Gly Tyr Thr Ala Ile Glu Lys Val Val Gln Met Thr Asn Asp Asp Ile 
    930                 935                 940                 


Lys Arg Ile Gly Val Arg Leu Pro Gly His Gln Lys Arg Ile Ala Tyr 
945                 950                 955                 960 


Ser Leu Leu Gly Leu Lys Asp Gln Val Asn Thr Val Gly Ile Pro Ile 
                965                 970                 975     


<210>  1136
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  1136

Met Leu Pro Pro Met Ala Leu Pro Ser Val Ser Trp Met Leu Leu Ser 
1               5                   10                  15      


Cys Leu Ile Leu Leu Cys Gln Val Gln Gly Glu Glu Thr Gln Lys Glu 
            20                  25                  30          


Leu Pro Ser Pro Arg Ile Ser Cys Pro Lys Gly Ser Lys Ala Tyr Gly 
        35                  40                  45              


Ser Pro Cys Tyr Ala Leu Phe Leu Ser Pro Lys Ser Trp Met Asp Ala 
    50                  55                  60                  


Asp Leu Ala Cys Gln Lys Arg Pro Ser Gly Lys Leu Val Ser Val Leu 
65                  70                  75                  80  


Ser Gly Ala Glu Gly Ser Phe Val Ser Ser Leu Val Arg Ser Ile Ser 
                85                  90                  95      


Asn Ser Tyr Ser Tyr Ile Trp Ile Gly Leu His Asp Pro Thr Gln Gly 
            100                 105                 110         


Ser Glu Pro Asp Gly Asp Gly Trp Glu Trp Ser Ser Thr Asp Val Met 
        115                 120                 125             


Asn Tyr Phe Ala Trp Glu Lys Asn Pro Ser Thr Ile Leu Asn Pro Gly 
    130                 135                 140                 


His Cys Gly Ser Leu Ser Arg Ser Thr Gly Phe Leu Lys Trp Lys Asp 
145                 150                 155                 160 


Tyr Asn Cys Asp Ala Lys Leu Pro Tyr Val Cys Lys Phe Lys Asp 
                165                 170                 175 


<210>  1137
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  1137

Met Lys Trp Val Glu Ser Ile Phe Leu Ile Phe Leu Leu Asn Phe Thr 
1               5                   10                  15      


Glu Ser Arg Thr Leu His Arg Asn Glu Tyr Gly Ile Ala Ser Ile Leu 
            20                  25                  30          


Asp Ser Tyr Gln Cys Thr Ala Glu Ile Ser Leu Ala Asp Leu Ala Thr 
        35                  40                  45              


Ile Phe Phe Ala Gln Phe Val Gln Glu Ala Thr Tyr Lys Glu Val Ser 
    50                  55                  60                  


Lys Met Val Lys Asp Ala Leu Thr Ala Ile Glu Lys Pro Thr Gly Asp 
65                  70                  75                  80  


Glu Gln Ser Ser Gly Cys Leu Glu Asn Gln Leu Pro Ala Phe Leu Glu 
                85                  90                  95      


Glu Leu Cys His Glu Lys Glu Ile Leu Glu Lys Tyr Gly His Ser Asp 
            100                 105                 110         


Cys Cys Ser Gln Ser Glu Glu Gly Arg His Asn Cys Phe Leu Ala His 
        115                 120                 125             


Lys Lys Pro Thr Pro Ala Ser Ile Pro Leu Phe Gln Val Pro Glu Pro 
    130                 135                 140                 


Val Thr Ser Cys Glu Ala Tyr Glu Glu Asp Arg Glu Thr Phe Met Asn 
145                 150                 155                 160 


Lys Phe Ile Tyr Glu Ile Ala Arg Arg His Pro Phe Leu Tyr Ala Pro 
                165                 170                 175     


Thr Ile Leu Leu Trp Ala Ala Arg Tyr Asp Lys Ile Ile Pro Ser Cys 
            180                 185                 190         


Cys Lys Ala Glu Asn Ala Val Glu Cys Phe Gln Thr Lys Ala Ala Thr 
        195                 200                 205             


Val Thr Lys Glu Leu Arg Glu Ser Ser Leu Leu Asn Gln His Ala Cys 
    210                 215                 220                 


Ala Val Met Lys Asn Phe Gly Thr Arg Thr Phe Gln Ala Ile Thr Val 
225                 230                 235                 240 


Thr Lys Leu Ser Gln Lys Phe Thr Lys Val Asn Phe Thr Glu Ile Gln 
                245                 250                 255     


Lys Leu Val Leu Asp Val Ala His Val His Glu His Cys Cys Arg Gly 
            260                 265                 270         


Asp Val Leu Asp Cys Leu Gln Asp Gly Glu Lys Ile Met Ser Tyr Ile 
        275                 280                 285             


Cys Ser Gln Gln Asp Thr Leu Ser Asn Lys Ile Thr Glu Cys Cys Lys 
    290                 295                 300                 


Leu Thr Thr Leu Glu Arg Gly Gln Cys Ile Ile His Ala Glu Asn Asp 
305                 310                 315                 320 


Glu Lys Pro Glu Gly Leu Ser Pro Asn Leu Asn Arg Phe Leu Gly Asp 
                325                 330                 335     


Arg Asp Phe Asn Gln Phe Ser Ser Gly Glu Lys Asn Ile Phe Leu Ala 
            340                 345                 350         


Ser Phe Val His Glu Tyr Ser Arg Arg His Pro Gln Leu Ala Val Ser 
        355                 360                 365             


Val Ile Leu Arg Val Ala Lys Gly Tyr Gln Glu Leu Leu Glu Lys Cys 
    370                 375                 380                 


Phe Gln Thr Glu Asn Pro Leu Glu Cys Gln Asp Lys Gly Glu Glu Glu 
385                 390                 395                 400 


Leu Gln Lys Tyr Ile Gln Glu Ser Gln Ala Leu Ala Lys Arg Ser Cys 
                405                 410                 415     


Gly Leu Phe Gln Lys Leu Gly Glu Tyr Tyr Leu Gln Asn Ala Phe Leu 
            420                 425                 430         


Val Ala Tyr Thr Lys Lys Ala Pro Gln Leu Thr Ser Ser Glu Leu Met 
        435                 440                 445             


Ala Ile Thr Arg Lys Met Ala Ala Thr Ala Ala Thr Cys Cys Gln Leu 
    450                 455                 460                 


Ser Glu Asp Lys Leu Leu Ala Cys Gly Glu Gly Ala Ala Asp Ile Ile 
465                 470                 475                 480 


Ile Gly His Leu Cys Ile Arg His Glu Met Thr Pro Val Asn Pro Gly 
                485                 490                 495     


Val Gly Gln Cys Cys Thr Ser Ser Tyr Ala Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ser Leu Val Val Asp Glu Thr Tyr Val Pro Pro Ala Phe Ser Asp 
        515                 520                 525             


Asp Lys Phe Ile Phe His Lys Asp Leu Cys Gln Ala Gln Gly Val Ala 
    530                 535                 540                 


Leu Gln Thr Met Lys Gln Glu Phe Leu Ile Asn Leu Val Lys Gln Lys 
545                 550                 555                 560 


Pro Gln Ile Thr Glu Glu Gln Leu Glu Ala Val Ile Ala Asp Phe Ser 
                565                 570                 575     


Gly Leu Leu Glu Lys Cys Cys Gln Gly Gln Glu Gln Glu Val Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Gln Lys Leu Ile Ser Lys Thr Arg Ala Ala Leu Gly 
        595                 600                 605             


Val 
    


<210>  1138
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  1138

Met Ala Pro Pro Gln Val Leu Ala Phe Gly Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Thr Ala Thr Phe Ala Ala Ala Gln Glu Glu Cys Val Cys Glu Asn Tyr 
            20                  25                  30          


Lys Leu Ala Val Asn Cys Phe Val Asn Asn Asn Arg Gln Cys Gln Cys 
        35                  40                  45              


Thr Ser Val Gly Ala Gln Asn Thr Val Ile Cys Ser Lys Leu Ala Ala 
    50                  55                  60                  


Lys Cys Leu Val Met Lys Ala Glu Met Asn Gly Ser Lys Leu Gly Arg 
65                  70                  75                  80  


Arg Ala Lys Pro Glu Gly Ala Leu Gln Asn Asn Asp Gly Leu Tyr Asp 
                85                  90                  95      


Pro Asp Cys Asp Glu Ser Gly Leu Phe Lys Ala Lys Gln Cys Asn Gly 
            100                 105                 110         


Thr Ser Met Cys Trp Cys Val Asn Thr Ala Gly Val Arg Arg Thr Asp 
        115                 120                 125             


Lys Asp Thr Glu Ile Thr Cys Ser Glu Arg Val Arg Thr Tyr Trp Ile 
    130                 135                 140                 


Ile Ile Glu Leu Lys His Lys Ala Arg Glu Lys Pro Tyr Asp Ser Lys 
145                 150                 155                 160 


Ser Leu Arg Thr Ala Leu Gln Lys Glu Ile Thr Thr Arg Tyr Gln Leu 
                165                 170                 175     


Asp Pro Lys Phe Ile Thr Ser Ile Leu Tyr Glu Asn Asn Val Ile Thr 
            180                 185                 190         


Ile Asp Leu Val Gln Asn Ser Ser Gln Lys Thr Gln Asn Asp Val Asp 
        195                 200                 205             


Ile Ala Asp Val Ala Tyr Tyr Phe Glu Lys Asp Val Lys Gly Glu Ser 
    210                 215                 220                 


Leu Phe His Ser Lys Lys Met Asp Leu Thr Val Asn Gly Glu Gln Leu 
225                 230                 235                 240 


Asp Leu Asp Pro Gly Gln Thr Leu Ile Tyr Tyr Val Asp Glu Lys Ala 
                245                 250                 255     


Pro Glu Phe Ser Met Gln Gly Leu Lys Ala Gly Val Ile Ala Val Ile 
            260                 265                 270         


Val Val Val Val Ile Ala Val Val Ala Gly Ile Val Val Leu Val Ile 
        275                 280                 285             


Ser Arg Lys Lys Arg Met Ala Lys Tyr Glu Lys Ala Glu Ile Lys Glu 
    290                 295                 300                 


Met Gly Glu Met His Arg Glu Leu Asn Ala 
305                 310                 


<210>  1139
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  1139

Met Thr Ala Ser Ala Ala Ala Glu Leu Pro His Ser Lys Leu Leu Leu 
1               5                   10                  15      


Ser Ala Val Ser Val Lys Leu Glu Ala Ser Ala Gly Ala His Arg Ser 
            20                  25                  30          


His Cys Arg Ser Pro Pro His Leu Cys Ala Arg Val Arg Met Arg Ser 
        35                  40                  45              


Asp Gly Arg Asn Asn Val Val Phe Ser Ser Asp Gly Cys Gln Val Arg 
    50                  55                  60                  


His Thr His Ala Cys Leu Asp Arg Asp His Leu Ser Ser Ala Asp Pro 
65                  70                  75                  80  


Gly Gln Trp Ser Ala Gly His Val Arg Gln Trp Leu Asp Trp Ala Val 
                85                  90                  95      


Gln Glu Tyr Gly Leu Pro Pro Leu Asp Val Ser Leu Phe Gln Gly Val 
            100                 105                 110         


Asp Gly Lys Gln Leu Cys Arg Met Ser Arg Glu Glu Leu Gln Arg Leu 
        115                 120                 125             


Thr Ser Ser Tyr Ser Ala Asp Val Leu Leu Ser His Leu His Tyr Leu 
    130                 135                 140                 


Arg Glu Thr Pro Leu Pro His Leu Thr Ser Asp Asp Val Asp Lys Ala 
145                 150                 155                 160 


Leu Gln Asn Ser Pro Arg Leu Met His Ala Arg Asn Thr Gly Gly Ala 
                165                 170                 175     


Asn Phe Ile Phe Pro Asn Thr Pro Val Tyr Pro Pro Asp Ala Ser Arg 
            180                 185                 190         


Gly Ala Ser Arg Ala Asp Val Gly Tyr Asp Ala Val Arg Arg Ser Gly 
        195                 200                 205             


Trp Thr Pro Ala Leu Pro Ala Ala Lys Val Ser Gln Ser Ser Ala Ala 
    210                 215                 220                 


Ile Met Ser Lys Thr Glu Glu Gln Arg Ala Gln Leu Asp Pro Tyr Gln 
225                 230                 235                 240 


Ile Leu Gly Pro Thr Ser Ser Arg Leu Ala Asn Pro Gly Ser Gly Gln 
                245                 250                 255     


Ile Gln Leu Trp Gln Phe Leu Leu Glu Leu Leu Ser Asp Ser Cys Asn 
            260                 265                 270         


Ser Ser Cys Ile Thr Trp Glu Gly Thr Asn Gly Glu Phe Lys Met Thr 
        275                 280                 285             


Asp Pro Asp Glu Val Ala Arg Arg Trp Gly Glu Arg Lys Ser Lys Pro 
    290                 295                 300                 


Asn Met Asn Tyr Asp Lys Leu Ser Arg Ala Leu Arg Tyr Tyr Tyr Asp 
305                 310                 315                 320 


Lys Asn Ile Met Thr Lys Val His Gly Lys Arg Tyr Ala Tyr Lys Phe 
                325                 330                 335     


Asp Phe His Gly Ile Ala Gln Ala Leu Gln Pro His Pro Pro Asp Ser 
            340                 345                 350         


Ser Ile Tyr Lys Tyr Pro Ala Val Ala Ala Asp Leu Pro Tyr Val Ser 
        355                 360                 365             


Ser Tyr His Pro Gln Lys Met Ser Phe Met Ala Pro His Pro Gln Ala 
    370                 375                 380                 


Met Ser Val Ser Ser Ser Gly Phe Phe Ser Gly Pro Ala Pro Tyr Trp 
385                 390                 395                 400 


Asn Thr Pro Ala Ala Gly Ile Tyr Gly Gly Pro Arg His Pro Pro Ala 
                405                 410                 415     


His Met Pro Ser His Leu Gly Ser Tyr Tyr 
            420                 425     


<210>  1140
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  1140

Val Leu Pro Asp Val Phe Ile Arg Cys Val 
1               5                   10  


<210>  1141
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  1141

Met Thr Thr Leu Ala Gly Ala Val Pro Arg Met Met Arg Pro Gly Pro 
1               5                   10                  15      


Gly Gln Asn Tyr Pro Arg Ser Gly Phe Pro Leu Glu Val Ser Thr Pro 
            20                  25                  30          


Leu Gly Gln Gly Arg Val Asn Gln Leu Gly Gly Val Phe Ile Asn Gly 
        35                  40                  45              


Arg Pro Leu Pro Asn His Ile Arg His Lys Ile Val Glu Met Ala His 
    50                  55                  60                  


His Gly Ile Arg Pro Cys Val Ile Ser Arg Gln Leu Arg Val Ser His 
65                  70                  75                  80  


Gly Cys Val Ser Lys Ile Leu Cys Arg Tyr Gln Glu Thr Gly Ser Ile 
                85                  90                  95      


Arg Pro Gly Ala Ile Gly Gly Ser Lys Pro Lys Gln Val Thr Thr Pro 
            100                 105                 110         


Asp Val Glu Lys Lys Ile Glu Glu Tyr Lys Arg Glu Asn Pro Gly Met 
        115                 120                 125             


Phe Ser Trp Glu Ile Arg Asp Lys Leu Leu Lys Asp Ala Val Cys Asp 
    130                 135                 140                 


Arg Asn Thr Val Pro Ser Val Ser Ser Ile Ser Arg Ile Leu Arg Ser 
145                 150                 155                 160 


Lys Phe Gly Lys Gly Glu Glu Glu Glu Ala Asp Leu Glu Arg Lys Glu 
                165                 170                 175     


Ala Glu Glu Ser Glu Lys Lys Ala Lys His Ser Ile Asp Gly Ile Leu 
            180                 185                 190         


Ser Glu Arg Ala Ser Ala Pro Gln Ser Asp Glu Gly Ser Asp Ile Asp 
        195                 200                 205             


Ser Glu Pro Asp Leu Pro Leu Lys Arg Lys Gln Arg Arg Ser Arg Thr 
    210                 215                 220                 


Thr Phe Thr Ala Glu Gln Leu Glu Glu Leu Glu Arg Ala Phe Glu Arg 
225                 230                 235                 240 


Thr His Tyr Pro Asp Ile Tyr Thr Arg Glu Glu Leu Ala Gln Arg Ala 
                245                 250                 255     


Lys Leu Thr Glu Ala Arg Val Gln Val Trp Phe Ser Asn Arg Arg Ala 
            260                 265                 270         


Arg Trp Arg Lys Gln Ala Gly Ala Asn Gln Leu Met Ala Phe Asn His 
        275                 280                 285             


Leu Ile Pro Gly Gly Phe Pro Pro Thr Ala Met Pro Thr Leu Pro Thr 
    290                 295                 300                 


Tyr Gln Leu Ser Glu Thr Ser Tyr Gln Pro Thr Ser Ile Pro Gln Ala 
305                 310                 315                 320 


Val Ser Asp Pro Ser Ser Thr Val His Arg Pro Gln Pro Leu Pro Pro 
                325                 330                 335     


Ser Thr Val His Gln Ser Thr Ile Pro Ser Asn Pro Asp Ser Ser Ser 
            340                 345                 350         


Ala Tyr Cys Leu Pro Ser Thr Arg His Gly Phe Ser Ser Tyr Thr Asp 
        355                 360                 365             


Ser Phe Val Pro Pro Ser Gly Pro Ser Asn Pro Met Asn Pro Thr Ile 
    370                 375                 380                 


Gly Asn Gly Leu Ser Pro Gln Val Met Gly Leu Leu Thr Asn His Gly 
385                 390                 395                 400 


Gly Val Pro His Gln Pro Gln Thr Asp Tyr Ala Leu Ser Pro Leu Thr 
                405                 410                 415     


Gly Gly Leu Glu Pro Thr Thr Thr Val Ser Ala Ser Cys Ser Gln Arg 
            420                 425                 430         


Leu Asp His Met Lys Ser Leu Asp Ser Leu Pro Thr Ser Gln Ser Tyr 
        435                 440                 445             


Cys Pro Pro Thr Tyr Ser Thr Thr Gly Tyr Ser Met Asp Pro Val Thr 
    450                 455                 460                 


Gly Tyr Gln Tyr Gly Gln Tyr Gly Gln Ser Lys Pro Trp Thr Phe 
465                 470                 475                 


<210>  1142
<211>  1195
<212>  PRT
<213>  Homo sapiens

<400>  1142

Met Lys Thr Gly Leu Leu Val Leu Leu Val Cys Ser Ala Ala Phe Phe 
1               5                   10                  15      


Ala Gly Arg Arg Cys Ala Ala Thr Gly Met Asp Pro Pro Ser Ala Gly 
            20                  25                  30          


Phe Ser Asn Gly Thr Ser Gly Asp Gly Gly Ser Lys Arg Asp Ser Asn 
        35                  40                  45              


Gln Thr Met Leu Ser Arg Asn Lys Arg Lys Thr Leu Ala Val Asp Phe 
    50                  55                  60                  


Ala Val Pro Ser Leu Leu Arg Tyr Tyr Leu Ala Glu Phe Ile Lys Arg 
65                  70                  75                  80  


Pro Leu Asn Gly Asp Cys Gln Ile Phe Arg Gly Cys Tyr Ala Leu Arg 
                85                  90                  95      


Ala Asn Leu Lys Met Leu Cys Val Pro Leu Gln Lys Thr Ile Ser Thr 
            100                 105                 110         


Phe Val Asp Pro Arg Ala Ala Lys Asp Pro Glu Asn Arg Ser Ala Glu 
        115                 120                 125             


Gly Gln Leu Pro Phe Ile Tyr Gln Arg Pro Leu Ser Lys Val Leu Asn 
    130                 135                 140                 


Leu Gly Leu Thr Lys Ala Ser Arg Lys Ser Asn Gln Val Val Val Glu 
145                 150                 155                 160 


Ile Gly Glu Asp Ile Val Arg Thr Gly Cys Gly Gly Leu Thr Val His 
                165                 170                 175     


Glu Glu Asp Pro Val Leu Val Leu Glu Met Asp Leu Thr Thr Ile Leu 
            180                 185                 190         


Glu Trp Trp Leu Gly Ala Glu Gly Gly Arg Leu Arg Val Arg Leu Met 
        195                 200                 205             


Pro Glu Lys Lys Ala Gln Val Pro Gly Met Glu Asp Arg Tyr Thr Thr 
    210                 215                 220                 


Ala Ile Arg Ala Ala Asp Pro Arg Leu Ser Leu Glu Ile Ser Ser Arg 
225                 230                 235                 240 


Gly Glu Pro Leu Gly Gly Arg Asn Ala Ala Gly Ile Pro Arg Gly Pro 
                245                 250                 255     


Trp Ser Phe Ser Trp Val Ala Glu Asp Asp Leu Ser Phe Pro Asn Ala 
            260                 265                 270         


Val Pro Lys Ser Asp His Gln Cys Pro Gly Lys Gly Gly Thr Cys Asp 
        275                 280                 285             


Pro Gln Thr Glu Glu Ile Pro Glu Phe Thr Trp Ser Ile Val Ala Asp 
    290                 295                 300                 


Gly Asn Leu Gln Glu Glu Arg Ser Gly Arg Ala Gly Lys Lys Thr Gly 
305                 310                 315                 320 


Ser Pro Gln Gly Trp Glu Glu Gly Gln Phe Phe Trp Val Asn Gly Ser 
                325                 330                 335     


Ala Phe Gly Gly Pro Trp Ala Leu Ser Pro Trp Leu Trp Gly Gly Gln 
            340                 345                 350         


Gly Leu Cys Thr Leu Asp Met Ala Val Phe Phe His Pro Lys Gln Ser 
        355                 360                 365             


Gly Gln Tyr Thr Ile Arg Leu Leu Glu Arg Asp Lys Pro Pro Gln Ala 
    370                 375                 380                 


Leu Val Ser Thr Asp Thr Leu Pro Arg Ile Thr Gly Trp Ala Val Val 
385                 390                 395                 400 


His Leu Thr Leu Gly Thr Arg Gly Gly Ala Pro Phe Arg Val Ser Ala 
                405                 410                 415     


Gly Tyr Asp Gln Arg Ile Pro Gln Glu Asp Ala Ala Thr Ile Glu Pro 
            420                 425                 430         


His Phe Thr Thr Asn Cys Thr Met Ala Ser Pro Pro Gly Pro Asn Ile 
        435                 440                 445             


Thr Leu Glu Gly Gln Tyr His Cys His Gln Gly Pro Gly Ile Pro Leu 
    450                 455                 460                 


Asp Lys Leu Cys Asp Phe Ser Thr Asp Cys Pro Leu Gly Asp Asp Glu 
465                 470                 475                 480 


Gly Asp Arg Cys Arg Arg Phe Leu Asn Gly Ser Tyr Cys Ser Phe Glu 
                485                 490                 495     


Glu Gly Glu Cys Gly Trp Gln Ser Phe Ala Gly Arg Ser Leu Ser Trp 
            500                 505                 510         


Arg Arg Val Gln Ser Ala Ala Lys Pro Gly Arg Gln Ser Cys Pro Ser 
        515                 520                 525             


Ser Gly Ala Thr Phe Thr Val Glu Gly Gly Gln Ser Lys Gly Gln Arg 
    530                 535                 540                 


Gly Ser Val Leu Leu Lys Ser Pro Leu Phe Pro Pro Pro Leu Arg Asn 
545                 550                 555                 560 


Ser Pro Cys Thr Val Arg Phe Trp Leu Cys Ser Gly Gly Leu Gln Arg 
                565                 570                 575     


Asn Ser Leu Ser Leu Trp Ile Val Glu Asn Ser Thr Gly Pro Asp Glu 
            580                 585                 590         


Gln Arg Arg Leu Trp His Leu Ala Gly Glu Ser Lys Pro Glu Arg Gly 
        595                 600                 605             


Trp Arg Leu Val Thr Ile Pro Leu Tyr Gly Leu Ala Asp Trp Phe Trp 
    610                 615                 620                 


Leu Gln Phe Ser Ala Glu Asp Gly Pro Gly Pro Gly Ser Thr Val Ser 
625                 630                 635                 640 


Leu Asp Asn Val Ser Phe Ser Met Asp Cys Phe Leu Ala Ser Asn Gly 
                645                 650                 655     


Glu Phe Pro Pro Val Ala Ser Ser Thr Ser Arg Ile Ser Ser Arg Pro 
            660                 665                 670         


Thr Ser Arg Thr Pro Thr Pro Ser Val Arg Ser Pro Thr Val Ser Phe 
        675                 680                 685             


Pro Thr Thr Asp Tyr Ser Lys Lys Trp Ile Phe His Thr Cys Gly Ala 
    690                 695                 700                 


Ala Gly Pro Glu Gly Pro Thr Pro Ser Gln Cys Leu Asn Ser Tyr Arg 
705                 710                 715                 720 


Asn Thr Asn Val Asn Val Thr Val Gly Thr Ser Gly Ser Phe Lys Gly 
                725                 730                 735     


Ile Gln Met Trp Arg Val Pro Glu Thr Gly Thr Tyr Arg Ile Thr Ala 
            740                 745                 750         


Tyr Gly Ala Ala Gly Gly Arg Ser Val Thr Ala Met Ser Arg Ser His 
        755                 760                 765             


Gly Val Tyr Ile Thr Gly Asp Phe Leu Leu Arg Arg Gly Glu Leu Leu 
    770                 775                 780                 


His Val Leu Val Gly Gln Gln Gly Glu Asp Ala Cys Pro Asn Ala Asn 
785                 790                 795                 800 


Ala Val Leu Asn Lys Ile Cys Leu Glu Gln Ser Gly Pro Leu Val Asn 
                805                 810                 815     


Lys Ser Gln Val Lys Gly Gly Gly Gly Gly Gly Gly Gly Ala Thr Tyr 
            820                 825                 830         


Val Phe Lys Leu Asp Gly Asn Val His Val Pro Leu Ile Ile Ala Ala 
        835                 840                 845             


Gly Gly Gly Gly Arg Gly Tyr Ser Ser Gln Ser Glu Thr Gln Leu Glu 
    850                 855                 860                 


Gln Met Asp Tyr Asp Leu Ser Gln Pro Gly Arg Asn Gly Arg Ser Asn 
865                 870                 875                 880 


Ser Ser Gly Gly Gly Gly Gly Trp Asn Asp Ser Ala Pro Val Ser Gln 
                885                 890                 895     


Gly Gly Arg Pro Leu Val Leu Gly Gly Gln Gly Gly Gln Ala Cys Gln 
            900                 905                 910         


Lys Phe Trp Gln Thr Arg Gly Gly Phe Gly Gly Gly Gly Gly Gly Cys 
        915                 920                 925             


Met Ser Gly Gly Gly Gly Gly Gly Tyr Arg Gly Gly Asn Thr Ser Leu 
    930                 935                 940                 


His Asp Asn Pro Arg Ala Asp Gly Asp Asp Gly Thr Ser Phe Leu Gly 
945                 950                 955                 960 


Pro Asp Gly Glu Pro Phe Leu Tyr Pro Leu Lys Ala Met Glu Gly Asp 
                965                 970                 975     


Gly Glu Val Ile Ile Ser Pro Val Gln Asn Cys Ser His Cys Glu Ser 
            980                 985                 990         


Gly Glu Cys His Glu Ser Lys Asp  Gly Val Thr Cys Tyr  Cys Asp Glu 
        995                 1000                 1005             


Glu Leu  Ile Leu Ala Pro Asp  Gly Val Ser Cys Ile  Asn Ala Ser 
    1010                 1015                 1020             


Asp Val  Ser Leu Leu Pro Pro  Gln Pro Ser Leu Ser  His Leu Ala 
    1025                 1030                 1035             


Leu Gly  Leu Ser Val Gly Thr  Ser Ala Leu Ile Ala  Ala Leu Leu 
    1040                 1045                 1050             


Leu Ala  Val Ser Gly Val Met  Ile Met Tyr Arg Arg  Lys His Thr 
    1055                 1060                 1065             


Glu Leu  Gln Ser Ile Gln Leu  Glu Leu Gln Ser Pro  Asp Cys Lys 
    1070                 1075                 1080             


Leu Ser  Lys Leu Arg Ala Ser  Thr Ile Met Thr Asp  Tyr Asn Pro 
    1085                 1090                 1095             


Asn Tyr  Cys Phe Ala Gly Lys  Thr Ala Ser Val Ser  Asp Leu Lys 
    1100                 1105                 1110             


Glu Val  Pro Arg Arg Asn Ile  Ser Leu Thr Arg Gly  Leu Gly His 
    1115                 1120                 1125             


Gly Ala  Phe Gly Glu Val Tyr  Glu Gly Leu Ala Val  Gly Ile Pro 
    1130                 1135                 1140             


Gly Glu  Pro Ser Pro Leu Gln  Val Ala Val Lys Thr  Leu Pro Glu 
    1145                 1150                 1155             


Val Cys  Ser Glu Gln Asp Glu  Leu Asp Phe Leu Met  Glu Ala Leu 
    1160                 1165                 1170             


Ile Ile  Ser Lys Phe Asn His  Gln Asn Ile Val Arg  Cys Ile Gly 
    1175                 1180                 1185             


Val Ser  Leu Gln Ala Met Pro  
    1190                 1195 


<210>  1143
<211>  920
<212>  PRT
<213>  Homo sapiens

<400>  1143

Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Ser Leu Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Glu Thr Ser Pro Arg Gln Gln Gln Gln Gln Gln Gly Glu Asp Gly Ser 
                85                  90                  95      


Pro Gln Ala His Arg Arg Gly Pro Thr Gly Tyr Leu Val Leu Asp Glu 
            100                 105                 110         


Glu Gln Gln Pro Ser Gln Pro Gln Ser Ala Leu Glu Cys His Pro Glu 
        115                 120                 125             


Arg Gly Cys Val Pro Glu Pro Gly Ala Ala Val Ala Ala Ser Lys Gly 
    130                 135                 140                 


Leu Pro Gln Gln Leu Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala Ala 
145                 150                 155                 160 


Pro Ser Thr Leu Ser Leu Leu Gly Pro Thr Phe Pro Gly Leu Ser Ser 
                165                 170                 175     


Cys Ser Ala Asp Leu Lys Asp Ile Leu Ser Glu Ala Ser Thr Met Gln 
            180                 185                 190         


Leu Leu Gln Gln Gln Gln Gln Glu Ala Val Ser Glu Gly Ser Ser Ser 
        195                 200                 205             


Gly Arg Ala Arg Glu Ala Ser Gly Ala Pro Thr Ser Ser Lys Asp Asn 
    210                 215                 220                 


Tyr Leu Gly Gly Thr Ser Thr Ile Ser Asp Asn Ala Lys Glu Leu Cys 
225                 230                 235                 240 


Lys Ala Val Ser Val Ser Met Gly Leu Gly Val Glu Ala Leu Glu His 
                245                 250                 255     


Leu Ser Pro Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Leu 
            260                 265                 270         


Leu Gly Val Pro Pro Ala Val Arg Pro Thr Pro Cys Ala Pro Leu Ala 
        275                 280                 285             


Glu Cys Lys Gly Ser Leu Leu Asp Asp Ser Ala Gly Lys Ser Thr Glu 
    290                 295                 300                 


Asp Thr Ala Glu Tyr Ser Pro Phe Lys Gly Gly Tyr Thr Lys Gly Leu 
305                 310                 315                 320 


Glu Gly Glu Ser Leu Gly Cys Ser Gly Ser Ala Ala Ala Gly Ser Ser 
                325                 330                 335     


Gly Thr Leu Glu Leu Pro Ser Thr Leu Ser Leu Tyr Lys Ser Gly Ala 
            340                 345                 350         


Leu Asp Glu Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe Pro 
        355                 360                 365             


Leu Ala Leu Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro His Pro His 
    370                 375                 380                 


Ala Arg Ile Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp Ala 
385                 390                 395                 400 


Ala Ala Ala Ala Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu His Gly 
                405                 410                 415     


Ala Gly Ala Ala Gly Pro Gly Ser Gly Ser Pro Ser Ala Ala Ala Ser 
            420                 425                 430         


Ser Ser Trp His Thr Leu Phe Thr Ala Glu Glu Gly Gln Leu Tyr Gly 
        435                 440                 445             


Pro Cys Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    450                 455                 460                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Ala Gly Ala Val Ala Pro 
465                 470                 475                 480 


Tyr Gly Tyr Thr Arg Pro Pro Gln Gly Leu Ala Gly Gln Glu Ser Asp 
                485                 490                 495     


Phe Thr Ala Pro Asp Val Trp Tyr Pro Gly Gly Met Val Ser Arg Val 
            500                 505                 510         


Pro Tyr Pro Ser Pro Thr Cys Val Lys Ser Glu Met Gly Pro Trp Met 
        515                 520                 525             


Asp Ser Tyr Ser Gly Pro Tyr Gly Asp Met Arg Leu Glu Thr Ala Arg 
    530                 535                 540                 


Asp His Val Leu Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Thr Cys 
545                 550                 555                 560 


Leu Ile Cys Gly Asp Glu Ala Ser Gly Cys His Tyr Gly Ala Leu Thr 
                565                 570                 575     


Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala Ala Glu Gly Lys Gln 
            580                 585                 590         


Lys Tyr Leu Cys Ala Ser Arg Asn Asp Cys Thr Ile Asp Lys Phe Arg 
        595                 600                 605             


Arg Lys Asn Cys Pro Ser Cys Arg Leu Arg Lys Cys Tyr Glu Ala Gly 
    610                 615                 620                 


Met Thr Leu Gly Ala Arg Lys Leu Lys Lys Leu Gly Asn Leu Lys Leu 
625                 630                 635                 640 


Gln Glu Glu Gly Glu Ala Ser Ser Thr Thr Ser Pro Thr Glu Glu Thr 
                645                 650                 655     


Thr Gln Lys Leu Thr Val Ser His Ile Glu Gly Tyr Glu Cys Gln Pro 
            660                 665                 670         


Ile Phe Leu Asn Val Leu Glu Ala Ile Glu Pro Gly Val Val Cys Ala 
        675                 680                 685             


Gly His Asp Asn Asn Gln Pro Asp Ser Phe Ala Ala Leu Leu Ser Ser 
    690                 695                 700                 


Leu Asn Glu Leu Gly Glu Arg Gln Leu Val His Val Val Lys Trp Ala 
705                 710                 715                 720 


Lys Ala Leu Pro Gly Phe Arg Asn Leu His Val Asp Asp Gln Met Ala 
                725                 730                 735     


Val Ile Gln Tyr Ser Trp Met Gly Leu Met Val Phe Ala Met Gly Trp 
            740                 745                 750         


Arg Ser Phe Thr Asn Val Asn Ser Arg Met Leu Tyr Phe Ala Pro Asp 
        755                 760                 765             


Leu Val Phe Asn Glu Tyr Arg Met His Lys Ser Arg Met Tyr Ser Gln 
    770                 775                 780                 


Cys Val Arg Met Arg His Leu Ser Gln Glu Phe Gly Trp Leu Gln Ile 
785                 790                 795                 800 


Thr Pro Gln Glu Phe Leu Cys Met Lys Ala Leu Leu Leu Phe Ser Ile 
                805                 810                 815     


Ile Pro Val Asp Gly Leu Lys Asn Gln Lys Phe Phe Asp Glu Leu Arg 
            820                 825                 830         


Met Asn Tyr Ile Lys Glu Leu Asp Arg Ile Ile Ala Cys Lys Arg Lys 
        835                 840                 845             


Asn Pro Thr Ser Cys Ser Arg Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
    850                 855                 860                 


Asp Ser Val Gln Pro Ile Ala Arg Glu Leu His Gln Phe Thr Phe Asp 
865                 870                 875                 880 


Leu Leu Ile Lys Ser His Met Val Ser Val Asp Phe Pro Glu Met Met 
                885                 890                 895     


Ala Glu Ile Ile Ser Val Gln Val Pro Lys Ile Leu Ser Gly Lys Val 
            900                 905                 910         


Lys Pro Ile Tyr Phe His Thr Gln 
        915                 920 


<210>  1144
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  1144

Met Phe Ile Ala Ser Lys Tyr Glu Glu Met Tyr Pro Pro Glu Ile Gly 
1               5                   10                  15      


Asp Phe Ala Phe Val Thr Asp Asn Thr Tyr Thr Lys His Gln Ile Arg 
            20                  25                  30          


Gln Met Glu Met Lys Ile Leu Arg Ala Leu Asn Phe Gly Leu Gly Arg 
        35                  40                  45              


Pro Leu Pro Leu His Phe Leu Arg Arg Ala Ser Lys Ile Gly Glu Val 
    50                  55                  60                  


Asp Val Glu Gln His Thr Leu Ala Lys Tyr Leu Met Glu Leu Thr Met 
65                  70                  75                  80  


Leu Asp Tyr Asp Met Val His Phe Pro Pro Ser Gln Ile Ala Ala Gly 
                85                  90                  95      


Ala Phe Cys Leu Ala Leu Lys Ile Leu Asp Asn Gly Glu Trp Thr Pro 
            100                 105                 110         


Thr 
    


<210>  1145
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  1145

Met Pro Ser Cys Ser Thr Ser Thr Met Pro Gly Met Ile Cys Lys Asn 
1               5                   10                  15      


Pro Asp Leu Glu Phe Asp Ser Leu Gln Pro Cys Phe Tyr Pro Asp Glu 
            20                  25                  30          


Asp Asp Phe Tyr Phe Gly Gly Pro Asp Ser Thr Pro Pro Gly Glu Asp 
        35                  40                  45              


Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser 
    50                  55                  60                  


Arg Gly Phe Ala Glu His Ser Ser Glu Pro Pro Ser Trp Val Thr Glu 
65                  70                  75                  80  


Met Leu Leu Glu Asn Glu Leu Trp Gly Ser Pro Ala Glu Glu Asp Ala 
                85                  90                  95      


Phe Gly Leu Gly Gly Leu Gly Gly Leu Thr Pro Asn Pro Val Ile Leu 
            100                 105                 110         


Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Arg Glu Lys Leu Glu Arg 
        115                 120                 125             


Ala Val Ser Glu Lys Leu Gln His Gly Arg Gly Pro Pro Thr Ala Gly 
    130                 135                 140                 


Ser Thr Ala Gln Ser Pro Gly Ala Gly Ala Ala Ser Pro Ala Gly Arg 
145                 150                 155                 160 


Gly His Gly Gly Ala Ala Gly Ala Gly Arg Ala Gly Ala Ala Leu Pro 
                165                 170                 175     


Ala Glu Leu Ala His Pro Ala Ala Glu Cys Val Asp Pro Ala Val Val 
            180                 185                 190         


Phe Pro Phe Pro Val Asn Lys Arg Glu Pro Ala Pro Val Pro Ala Ala 
        195                 200                 205             


Pro Ala Ser Ala Pro Ala Ala Gly Pro Ala Val Ala Ser Gly Ala Gly 
    210                 215                 220                 


Ile Ala Ala Pro Ala Gly Ala Pro Gly Val Ala Pro Pro Arg Pro Gly 
225                 230                 235                 240 


Gly Arg Gln Thr Ser Gly Gly Asp His Lys Ala Leu Ser Thr Ser Gly 
                245                 250                 255     


Glu Asp Thr Leu Ser Asp Ser Asp Asp Glu Asp Asp Glu Glu Glu Asp 
            260                 265                 270         


Glu Glu Glu Glu Ile Asp Val Val Thr Val Glu Lys Arg Arg Ser Ser 
        275                 280                 285             


Ser Asn Thr Lys Ala Val Thr Thr Phe Thr Ile Thr Val Arg Pro Lys 
    290                 295                 300                 


Asn Ala Ala Leu Gly Pro Gly Arg Ala Gln Ser Ser Glu Leu Ile Leu 
305                 310                 315                 320 


Lys Arg Cys Leu Pro Ile His Gln Gln His Asn Tyr Ala Ala Pro Ser 
                325                 330                 335     


Pro Tyr Val Glu Ser Glu Asp Ala Pro Pro Gln Lys Lys Ile Lys Ser 
            340                 345                 350         


Glu Ala Ser Pro Arg Pro Leu Lys Ser Val Ile Pro Pro Lys Ala Lys 
        355                 360                 365             


Ser Leu Ser Pro Arg Asn Ser Asp Ser Glu Asp Ser Glu Arg Arg Arg 
    370                 375                 380                 


Asn His Asn Ile Leu Glu Arg Gln Arg Arg Asn Asp Leu Arg Ser Ser 
385                 390                 395                 400 


Phe Leu Thr Leu Arg Asp His Val Pro Glu Leu Val Lys Asn Glu Lys 
                405                 410                 415     


Ala Ala Lys Val Val Ile Leu Lys Lys Ala Thr Glu Tyr Val His Ser 
            420                 425                 430         


Leu Gln Ala Glu Glu His Gln Leu Leu Leu Glu Lys Glu Lys Leu Gln 
        435                 440                 445             


Ala Arg Gln Gln Gln Leu Leu Lys Lys Ile Glu His Ala Arg Thr Cys 
    450                 455                 460                 


<210>  1146
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  1146

Met Ala Ala Ile Arg Lys Lys Leu Val Ile Val Gly Asp Gly Ala Cys 
1               5                   10                  15      


Gly Lys Thr Cys Leu Leu Ile Val Phe Ser Lys Asp Gln Phe Pro Glu 
            20                  25                  30          


Val Tyr Val Pro Thr Val Phe Glu Asn Tyr Ile Ala Asp Ile Glu Val 
        35                  40                  45              


Asp Gly Lys Gln Val Glu Leu Ala Leu Trp Asp Thr Ala Gly Gln Glu 
    50                  55                  60                  


Asp Tyr Asp Arg Leu Arg Pro Leu Ser Tyr Pro Asp Thr Asp Val Ile 
65                  70                  75                  80  


Leu Met Cys Phe Ser Ile Asp Ser Pro Asp Ser Leu Glu Asn Ile Pro 
                85                  90                  95      


Glu Lys Trp Thr Pro Glu Val Lys His Phe Cys Pro Asn Val Pro Ile 
            100                 105                 110         


Ile Leu Val Gly Asn Lys Lys Asp Leu Arg Gln Asp Glu His Thr Arg 
        115                 120                 125             


Arg Glu Leu Ala Lys Met Lys Gln Glu Pro Val Arg Ser Glu Glu Gly 
    130                 135                 140                 


Arg Asp Met Ala Asn Arg Ile Ser Ala Phe Gly Tyr Leu Glu Cys Ser 
145                 150                 155                 160 


Ala Lys Thr Lys Glu Gly Val Arg Glu Val Phe Glu Met Ala Thr Arg 
                165                 170                 175     


Ala Gly Leu Gln Val Arg Lys Asn Lys Arg Arg Arg Gly Cys Pro Ile 
            180                 185                 190         


Leu 
    


<210>  1147
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  1147

Met Ser Pro Leu Trp Trp Gly Phe Leu Leu Ser Cys Leu Gly Cys Lys 
1               5                   10                  15      


Ile Leu Pro Gly Ala Gln Gly Gln Phe Pro Arg Val Cys Met Thr Val 
            20                  25                  30          


Asp Ser Leu Val Asn Lys Glu Cys Cys Pro Arg Leu Gly Ala Glu Ser 
        35                  40                  45              


Ala Asn Val Cys Gly Ser Gln Gln Gly Arg Gly Gln Cys Thr Glu Val 
    50                  55                  60                  


Arg Ala Asp Thr Arg Pro Trp Ser Gly Pro Tyr Ile Leu Arg Asn Gln 
65                  70                  75                  80  


Asp Asp Arg Glu Leu Trp Pro Arg Lys Phe Phe His Arg Thr Cys Lys 
                85                  90                  95      


Cys Thr Gly Asn Phe Ala Gly Tyr Asn Cys Gly Asp Cys Lys Phe Gly 
            100                 105                 110         


Trp Thr Gly Pro Asn Cys Glu Arg Lys Lys Pro Pro Val Ile Arg Gln 
        115                 120                 125             


Asn Ile His Ser Leu Ser Pro Gln Glu Arg Glu Gln Phe Leu Gly Ala 
    130                 135                 140                 


Leu Asp Leu Ala Lys Lys Arg Val His Pro Asp Tyr Val Ile Thr Thr 
145                 150                 155                 160 


Gln His Trp Val Gly Leu Leu Gly Pro Asn Gly Thr Gln Pro Gln Phe 
                165                 170                 175     


Ala Asn Cys Ser Val Tyr Asp Phe Phe Val Trp Leu His Tyr Tyr Ser 
            180                 185                 190         


Val Arg Asp Thr Leu Leu Gly Gly Phe Phe Pro Trp Leu Lys Val Tyr 
        195                 200                 205             


Tyr Tyr Arg Phe Val Ile Gly Leu Arg Val Trp Gln Trp Glu Val Ile 
    210                 215                 220                 


Ser Cys Lys Leu Ile Lys Arg Ala Thr Thr Arg Gln Pro 
225                 230                 235         


<210>  1148
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  1148

Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 
1               5                   10                  15      


Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 
            20                  25                  30          


Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 
        35                  40                  45              


Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 
    50                  55                  60                  


Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 
65                  70                  75                  80  


Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 
                85                  90                  95      


Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 
            100                 105                 110         


Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 
        115                 120                 125             


Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile 
    130                 135                 140                 


Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 
145                 150                 155                 160 


Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu 
                165                 170                 175     


Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu 
            180                 185                 190         


Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu 
        195                 200                 205             


Gly Ile Val Ala Ala Trp Arg Gln Arg Ser Ser Arg Asp Pro Ser Trp 
    210                 215                 220                 


Arg Gln Pro Glu Arg Thr Ile Leu Arg Pro Arg Phe Arg Arg Glu Val 
225                 230                 235                 240 


Glu Lys Thr Ala Cys Pro Ser Gly Lys Lys Ala Arg Glu Ile Asp Glu 
                245                 250                 255     


Ser Leu Ile Phe Tyr Lys Lys Trp Glu Leu Glu Ala Cys Val Asp Ala 
            260                 265                 270         


Ala Leu Leu Ala Thr Gln Met Asp Arg Val Asn Ala Ile Pro Phe Thr 
        275                 280                 285             


Tyr Glu Gln Leu Asp Val Leu Lys His Lys Leu Asp Glu Leu Tyr Pro 
    290                 295                 300                 


Gln Gly Tyr Pro Glu Ser Val Ile Gln His Leu Gly Tyr Leu Phe Leu 
305                 310                 315                 320 


Lys Met Ser Pro Glu Asp Ile Arg Lys Trp Asn Val 
                325                 330         


<210>  1149
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  1149

Met Ala Gly Leu Ala Leu Gln Pro Gly Thr Ala Leu Leu Cys Tyr Ser 
1               5                   10                  15      


Cys Lys Ala Gln Val Ser Asn Glu Asp Cys Leu Gln Val Glu Asn Cys 
            20                  25                  30          


Thr Gln Leu Gly Glu Gln Cys Trp Thr Ala Arg Ile Arg Glu Trp Gly 
        35                  40                  45              


Asp Asp Ser Arg Gln Ala 
    50                  


<210>  1150
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  1150

Met Gly Thr Ser Leu Ser Pro Asn Asp Pro Trp Pro Leu Asn Pro Leu 
1               5                   10                  15      


Ser Ile Gln Gln Thr Thr Leu Leu Leu Leu Leu Ser Val Leu Ala Thr 
            20                  25                  30          


Val His Val Gly Gln Arg Leu Leu Arg Gln Arg Arg Arg Gln Leu Arg 
        35                  40                  45              


Ser Ala Pro Pro Gly Pro Phe Ala Trp Pro Leu Ile Gly Asn Ala Ala 
    50                  55                  60                  


Ala Val Gly Gln Ala Ala His Leu Ser Phe Ala Arg Leu Ala Arg Arg 
65                  70                  75                  80  


Tyr Gly Asp Val Phe Gln Ile Arg Leu Gly Ser Cys Pro Ile Val Val 
                85                  90                  95      


Leu Asn Gly Glu Arg Ala Ile His Gln Ala Leu Val Gln Gln Gly Ser 
            100                 105                 110         


Ala Phe Ala Asp Arg Pro Ala Phe Ala Ser Phe Arg Val Val Ser Gly 
        115                 120                 125             


Gly Arg Ser Met Ala Phe Gly His Tyr Ser Glu His Trp Lys Val Gln 
    130                 135                 140                 


Arg Arg Ala Ala His Ser Met Met Arg Asn Phe Phe Thr Arg Gln Pro 
145                 150                 155                 160 


Arg Ser Arg Gln Val Leu Glu Gly His Val Leu Ser Glu Ala Arg Glu 
                165                 170                 175     


Leu Val Ala Leu Leu Val Arg Gly Ser Ala Asp Gly Ala Phe Leu Asp 
            180                 185                 190         


Pro Arg Pro Leu Thr Val Val Ala Val Ala Asn Val Met Ser Ala Val 
        195                 200                 205             


Cys Phe Gly Cys Arg Tyr Ser His Asp Asp Pro Glu Phe Arg Glu Leu 
    210                 215                 220                 


Leu Ser His Asn Glu Glu Phe Gly Arg Thr Val Gly Ala Gly Ser Leu 
225                 230                 235                 240 


Val Asp Val Met Pro Trp Leu Gln Tyr Phe Pro Asn Pro Val Arg Thr 
                245                 250                 255     


Val Phe Arg Glu Phe Glu Gln Leu Asn Arg Asn Phe Ser Asn Phe Ile 
            260                 265                 270         


Leu Asp Lys Phe Leu Arg His Cys Glu Ser Leu Arg Pro Gly Ala Ala 
        275                 280                 285             


Pro Arg Asp Met Met Asp Ala Phe Ile Leu Ser Ala Glu Lys Lys Ala 
    290                 295                 300                 


Ala Gly Asp Ser His Gly Gly Gly Ala Arg Leu Asp Leu Glu Asn Val 
305                 310                 315                 320 


Pro Ala Thr Ile Thr Asp Ile Phe Gly Ala Ser Gln Asp Thr Leu Ser 
                325                 330                 335     


Thr Ala Leu Gln Trp Leu Leu Leu Leu Phe Thr Arg Tyr Pro Asp Val 
            340                 345                 350         


Gln Thr Arg Val Gln Ala Glu Leu Asp Gln Val Val Gly Arg Asp Arg 
        355                 360                 365             


Leu Pro Cys Met Gly Asp Gln Pro Asn Leu Pro Tyr Val Leu Ala Phe 
    370                 375                 380                 


Leu Tyr Glu Ala Met Arg Phe Ser Ser Phe Val Pro Val Thr Ile Pro 
385                 390                 395                 400 


His Ala Thr Thr Ala Asn Thr Ser Val Leu Gly Tyr His Ile Pro Lys 
                405                 410                 415     


Asp Thr Val Val Phe Val Asn Gln Trp Ser Val Asn His Asp Pro Leu 
            420                 425                 430         


Lys Trp Pro Asn Pro Glu Asn Phe Asp Pro Ala Arg Phe Leu Asp Lys 
        435                 440                 445             


Asp Gly Leu Ile Asn Lys Asp Leu Thr Ser Arg Val Met Ile Phe Ser 
    450                 455                 460                 


Val Gly Lys Arg Arg Cys Ile Gly Glu Glu Leu Ser Lys Met Gln Leu 
465                 470                 475                 480 


Phe Leu Phe Ile Ser Ile Leu Ala His Gln Cys Asp Phe Arg Ala Asn 
                485                 490                 495     


Pro Asn Glu Pro Ala Lys Met Asn Phe Ser Tyr Gly Leu Thr Ile Lys 
            500                 505                 510         


Pro Lys Ser Phe Lys Val Asn Val Thr Leu Arg Glu Ser Met Glu Leu 
        515                 520                 525             


Leu Asp Ser Ala Val Gln Asn Leu Gln Ala Lys Glu Thr Cys Gln 
    530                 535                 540             


<210>  1151
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  1151

Met Lys Val Phe Lys Phe Ile Gly Leu Met Ile Leu Leu Thr Ser Ala 
1               5                   10                  15      


Phe Ser Ala Gly Ser Gly Gln Ser Pro Met Thr Val Leu Cys Ser Ile 
            20                  25                  30          


Asp Trp Phe Met Val Thr Val His Pro Phe Met Leu Asn Asn Asp Val 
        35                  40                  45              


Cys Val His Phe His Glu Leu His Leu Gly Leu Gly Cys Pro Pro Asn 
    50                  55                  60                  


His Val Gln Pro His Ala Tyr Gln Phe Thr Tyr Arg Val Thr Glu Cys 
65                  70                  75                  80  


Gly Ile Arg Ala Lys Ala Val Ser Gln Asp Met Val Ile Tyr Ser Thr 
                85                  90                  95      


Glu Ile His Tyr Ser Ser Lys Gly Thr Pro Ser Lys Phe Val Ile Pro 
            100                 105                 110         


Val Ser Cys Ala Ala Pro Gln Lys Ser Pro Trp Leu Thr Lys Pro Cys 
        115                 120                 125             


Ser Met Arg Val Ala Ser Lys Ser Arg Ala Thr Ala Gln Lys Asp Glu 
    130                 135                 140                 


Lys Cys Tyr Glu Val Phe Ser Leu Ser Gln Ser Ser Gln Arg Pro Asn 
145                 150                 155                 160 


Cys Asp Cys Pro Pro Cys Val Phe Ser Glu Glu Glu His Thr Gln Val 
                165                 170                 175     


Pro Cys His Gln Ala Gly Ala Gln Glu Ala Gln Pro Leu Gln Pro Ser 
            180                 185                 190         


His Phe Leu Asp Ile Ser Glu Asp Trp Ser Leu His Thr Asp Asp Met 
        195                 200                 205             


Ile Gly Ser Met 
    210         


<210>  1152
<211>  663
<212>  PRT
<213>  Homo sapiens

<400>  1152

Met Ala Ala Thr Glu Ile Ser Val Leu Ser Glu Gln Phe Thr Lys Ile 
1               5                   10                  15      


Lys Glu Leu Glu Leu Met Pro Glu Lys Gly Leu Lys Glu Glu Glu Lys 
            20                  25                  30          


Asp Gly Val Cys Arg Glu Lys Asp His Arg Ser Pro Ser Glu Leu Glu 
        35                  40                  45              


Ala Glu Arg Thr Ser Gly Ala Phe Gln Asp Ser Val Leu Glu Glu Glu 
    50                  55                  60                  


Val Glu Leu Val Leu Ala Pro Ser Glu Glu Ser Glu Lys Tyr Ile Leu 
65                  70                  75                  80  


Thr Leu Gln Thr Val His Phe Thr Ser Glu Ala Val Glu Leu Gln Asp 
                85                  90                  95      


Met Ser Leu Leu Ser Ile Gln Gln Gln Glu Gly Val Gln Val Val Val 
            100                 105                 110         


Gln Gln Pro Gly Pro Gly Leu Leu Trp Leu Glu Glu Gly Pro Arg Gln 
        115                 120                 125             


Ser Leu Gln Gln Cys Val Ala Ile Ser Ile Gln Gln Glu Leu Tyr Ser 
    130                 135                 140                 


Pro Gln Glu Met Glu Val Leu Gln Phe His Ala Leu Glu Glu Asn Val 
145                 150                 155                 160 


Met Val Ala Ser Glu Asp Ser Lys Leu Ala Val Ser Leu Ala Glu Thr 
                165                 170                 175     


Thr Gly Leu Ile Lys Leu Glu Glu Glu Gln Glu Lys Asn Gln Leu Leu 
            180                 185                 190         


Ala Glu Arg Thr Lys Glu Gln Leu Phe Phe Val Glu Thr Met Ser Gly 
        195                 200                 205             


Asp Glu Arg Ser Asp Glu Ile Val Leu Thr Val Ser Asn Ser Asn Val 
    210                 215                 220                 


Glu Glu Gln Glu Asp Gln Pro Thr Ala Gly Gln Ala Asp Ala Glu Lys 
225                 230                 235                 240 


Ala Lys Ser Thr Lys Asn Gln Arg Lys Thr Lys Gly Ala Lys Gly Thr 
                245                 250                 255     


Phe His Cys Asp Val Cys Met Phe Thr Ser Ser Arg Met Ser Ser Phe 
            260                 265                 270         


Asn Arg His Met Lys Thr His Thr Ser Glu Lys Pro His Leu Cys His 
        275                 280                 285             


Leu Cys Leu Lys Thr Phe Arg Thr Val Thr Leu Leu Arg Asn His Val 
    290                 295                 300                 


Asn Thr His Thr Gly Thr Arg Pro Tyr Lys Cys Asn Asp Cys Asn Met 
305                 310                 315                 320 


Ala Phe Val Thr Ser Gly Glu Leu Val Arg His Arg Arg Tyr Lys His 
                325                 330                 335     


Thr His Glu Lys Pro Phe Lys Cys Ser Met Cys Lys Tyr Ala Ser Val 
            340                 345                 350         


Glu Ala Ser Lys Leu Lys Arg His Val Arg Ser His Thr Gly Glu Arg 
        355                 360                 365             


Pro Phe Gln Cys Cys Gln Cys Ser Tyr Ala Ser Arg Asp Thr Tyr Lys 
    370                 375                 380                 


Leu Lys Arg His Met Arg Thr His Ser Gly Glu Lys Pro Tyr Glu Cys 
385                 390                 395                 400 


His Ile Cys His Thr Arg Phe Thr Gln Ser Gly Thr Met Lys Ile His 
                405                 410                 415     


Ile Leu Gln Lys His Gly Glu Asn Val Pro Lys Tyr Gln Cys Pro His 
            420                 425                 430         


Cys Ala Thr Ile Ile Ala Arg Lys Ser Asp Leu Arg Val His Met Arg 
        435                 440                 445             


Asn Leu His Ala Tyr Ser Ala Ala Glu Leu Lys Cys Arg Tyr Cys Ser 
    450                 455                 460                 


Ala Val Phe His Glu Arg Tyr Ala Leu Ile Gln His Gln Lys Thr His 
465                 470                 475                 480 


Lys Asn Glu Lys Arg Phe Lys Cys Lys His Cys Ser Tyr Ala Cys Lys 
                485                 490                 495     


Gln Glu Arg His Met Thr Ala His Ile Arg Thr His Thr Gly Glu Lys 
            500                 505                 510         


Pro Phe Thr Cys Leu Ser Cys Asn Lys Cys Phe Arg Gln Lys Gln Leu 
        515                 520                 525             


Leu Asn Ala His Phe Arg Lys Tyr His Asp Ala Asn Phe Ile Pro Thr 
    530                 535                 540                 


Val Tyr Lys Cys Ser Lys Cys Gly Lys Gly Phe Ser Arg Trp Ile Asn 
545                 550                 555                 560 


Leu His Arg His Ser Glu Lys Cys Gly Ser Gly Glu Ala Lys Ser Ala 
                565                 570                 575     


Ala Ser Gly Lys Gly Arg Arg Thr Arg Lys Arg Lys Gln Thr Ile Leu 
            580                 585                 590         


Lys Glu Ala Thr Lys Gly Gln Lys Glu Ala Ala Lys Gly Trp Lys Glu 
        595                 600                 605             


Ala Ala Asn Gly Asp Glu Ala Ala Ala Glu Glu Ala Ser Thr Thr Lys 
    610                 615                 620                 


Gly Glu Gln Phe Pro Gly Glu Met Phe Pro Val Ala Cys Arg Glu Thr 
625                 630                 635                 640 


Thr Ala Arg Val Lys Glu Glu Val Asp Glu Gly Val Thr Cys Glu Met 
                645                 650                 655     


Leu Leu Asn Thr Met Asp Lys 
            660             


<210>  1153
<211>  2201
<212>  PRT
<213>  Homo sapiens

<400>  1153

Met Gly Ala Met Thr Gln Leu Leu Ala Gly Val Phe Leu Ala Phe Leu 
1               5                   10                  15      


Ala Leu Ala Thr Glu Gly Gly Val Leu Lys Lys Val Ile Arg His Lys 
            20                  25                  30          


Arg Gln Ser Gly Val Asn Ala Thr Leu Pro Glu Glu Asn Gln Pro Val 
        35                  40                  45              


Val Phe Asn His Val Tyr Asn Ile Lys Leu Pro Val Gly Ser Gln Cys 
    50                  55                  60                  


Ser Val Asp Leu Glu Ser Ala Ser Gly Glu Lys Asp Leu Ala Pro Pro 
65                  70                  75                  80  


Ser Glu Pro Ser Glu Ser Phe Gln Glu His Thr Val Asp Gly Glu Asn 
                85                  90                  95      


Gln Ile Val Phe Thr His Arg Ile Asn Ile Pro Arg Arg Ala Cys Gly 
            100                 105                 110         


Cys Ala Ala Ala Pro Asp Val Lys Glu Leu Leu Ser Arg Leu Glu Glu 
        115                 120                 125             


Leu Glu Asn Leu Val Ser Ser Leu Arg Glu Gln Cys Thr Ala Gly Ala 
    130                 135                 140                 


Gly Cys Cys Leu Gln Pro Ala Thr Gly Arg Leu Asp Thr Arg Pro Phe 
145                 150                 155                 160 


Cys Ser Gly Arg Gly Asn Phe Ser Thr Glu Gly Cys Gly Cys Val Cys 
                165                 170                 175     


Glu Pro Gly Trp Lys Gly Pro Asn Cys Ser Glu Pro Glu Cys Pro Gly 
            180                 185                 190         


Asn Cys His Leu Arg Gly Arg Cys Ile Asp Gly Gln Cys Ile Cys Asp 
        195                 200                 205             


Asp Gly Phe Thr Gly Glu Asp Cys Ser Gln Leu Ala Cys Pro Ser Asp 
    210                 215                 220                 


Cys Asn Asp Gln Gly Lys Cys Val Asn Gly Val Cys Ile Cys Phe Glu 
225                 230                 235                 240 


Gly Tyr Ala Gly Ala Asp Cys Ser Arg Glu Ile Cys Pro Val Pro Cys 
                245                 250                 255     


Ser Glu Glu His Gly Thr Cys Val Asp Gly Leu Cys Val Cys His Asp 
            260                 265                 270         


Gly Phe Ala Gly Asp Asp Cys Asn Lys Pro Leu Cys Leu Asn Asn Cys 
        275                 280                 285             


Tyr Asn Arg Gly Arg Cys Val Glu Asn Glu Cys Val Cys Asp Glu Gly 
    290                 295                 300                 


Phe Thr Gly Glu Asp Cys Ser Glu Leu Ile Cys Pro Asn Asp Cys Phe 
305                 310                 315                 320 


Asp Arg Gly Arg Cys Ile Asn Gly Thr Cys Tyr Cys Glu Glu Gly Phe 
                325                 330                 335     


Thr Gly Glu Asp Cys Gly Lys Pro Thr Cys Pro His Ala Cys His Thr 
            340                 345                 350         


Gln Gly Arg Cys Glu Glu Gly Gln Cys Val Cys Asp Glu Gly Phe Ala 
        355                 360                 365             


Gly Val Asp Cys Ser Glu Lys Arg Cys Pro Ala Asp Cys His Asn Arg 
    370                 375                 380                 


Gly Arg Cys Val Asp Gly Arg Cys Glu Cys Asp Asp Gly Phe Thr Gly 
385                 390                 395                 400 


Ala Asp Cys Gly Glu Leu Lys Cys Pro Asn Gly Cys Ser Gly His Gly 
                405                 410                 415     


Arg Cys Val Asn Gly Gln Cys Val Cys Asp Glu Gly Tyr Thr Gly Glu 
            420                 425                 430         


Asp Cys Ser Gln Leu Arg Cys Pro Asn Asp Cys His Ser Arg Gly Arg 
        435                 440                 445             


Cys Val Glu Gly Lys Cys Val Cys Glu Gln Gly Phe Lys Gly Tyr Asp 
    450                 455                 460                 


Cys Ser Asp Met Ser Cys Pro Asn Asp Cys His Gln His Gly Arg Cys 
465                 470                 475                 480 


Val Asn Gly Met Cys Val Cys Asp Asp Gly Tyr Thr Gly Glu Asp Cys 
                485                 490                 495     


Arg Asp Arg Gln Cys Pro Arg Asp Cys Ser Asn Arg Gly Leu Cys Val 
            500                 505                 510         


Asp Gly Gln Cys Val Cys Glu Asp Gly Phe Thr Gly Pro Asp Cys Ala 
        515                 520                 525             


Glu Leu Ser Cys Pro Asn Asp Cys His Gly Gln Gly Arg Cys Val Asn 
    530                 535                 540                 


Gly Gln Cys Val Cys His Glu Gly Phe Met Gly Lys Asp Cys Lys Glu 
545                 550                 555                 560 


Gln Arg Cys Pro Ser Asp Cys His Gly Gln Gly Arg Cys Val Asp Gly 
                565                 570                 575     


Gln Cys Ile Cys His Glu Gly Phe Thr Gly Leu Asp Cys Gly Gln His 
            580                 585                 590         


Ser Cys Pro Ser Asp Cys Asn Asn Leu Gly Gln Cys Val Ser Gly Arg 
        595                 600                 605             


Cys Ile Cys Asn Glu Gly Tyr Ser Gly Glu Asp Cys Ser Glu Val Ser 
    610                 615                 620                 


Pro Pro Lys Asp Leu Val Val Thr Glu Val Thr Glu Glu Thr Val Asn 
625                 630                 635                 640 


Leu Ala Trp Asp Asn Glu Met Arg Val Thr Glu Tyr Leu Val Val Tyr 
                645                 650                 655     


Thr Pro Thr His Glu Gly Gly Leu Glu Met Gln Phe Arg Val Pro Gly 
            660                 665                 670         


Asp Gln Thr Ser Thr Ile Ile Gln Glu Leu Glu Pro Gly Val Glu Tyr 
        675                 680                 685             


Phe Ile Arg Val Phe Ala Ile Leu Glu Asn Lys Lys Ser Ile Pro Val 
    690                 695                 700                 


Ser Ala Arg Val Ala Thr Tyr Leu Pro Ala Pro Glu Gly Leu Lys Phe 
705                 710                 715                 720 


Lys Ser Ile Lys Glu Thr Ser Val Glu Val Glu Trp Asp Pro Leu Asp 
                725                 730                 735     


Ile Ala Phe Glu Thr Trp Glu Ile Ile Phe Arg Asn Met Asn Lys Glu 
            740                 745                 750         


Asp Glu Gly Glu Ile Thr Lys Ser Leu Arg Arg Pro Glu Thr Ser Tyr 
        755                 760                 765             


Arg Gln Thr Gly Leu Ala Pro Gly Gln Glu Tyr Glu Ile Ser Leu His 
    770                 775                 780                 


Ile Val Lys Asn Asn Thr Arg Gly Pro Gly Leu Lys Arg Val Thr Thr 
785                 790                 795                 800 


Thr Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp 
                805                 810                 815     


Thr Thr Ala Leu Ile Thr Trp Phe Lys Pro Leu Ala Glu Ile Asp Gly 
            820                 825                 830         


Ile Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr 
        835                 840                 845             


Ile Asp Leu Thr Glu Asp Glu Asn Gln Tyr Ser Ile Gly Asn Leu Lys 
    850                 855                 860                 


Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser Arg Arg Gly Asp Met 
865                 870                 875                 880 


Ser Ser Asn Pro Ala Lys Glu Thr Phe Thr Thr Gly Leu Asp Ala Pro 
                885                 890                 895     


Arg Asn Leu Arg Arg Val Ser Gln Thr Asp Asn Ser Ile Thr Leu Glu 
            900                 905                 910         


Trp Arg Asn Gly Lys Ala Ala Ile Asp Ser Tyr Arg Ile Lys Tyr Ala 
        915                 920                 925             


Pro Ile Ser Gly Gly Asp His Ala Glu Val Asp Val Pro Lys Ser Gln 
    930                 935                 940                 


Gln Ala Thr Thr Lys Thr Thr Leu Thr Gly Leu Arg Pro Gly Thr Glu 
945                 950                 955                 960 


Tyr Gly Ile Gly Val Ser Ala Val Lys Glu Asp Lys Glu Ser Asn Pro 
                965                 970                 975     


Ala Thr Ile Asn Ala Ala Thr Glu Leu Asp Thr Pro Lys Asp Leu Gln 
            980                 985                 990         


Val Ser Glu Thr Ala Glu Thr Ser  Leu Thr Leu Leu Trp  Lys Thr Pro 
        995                 1000                 1005             


Leu Ala  Lys Phe Asp Arg Tyr  Arg Leu Asn Tyr Ser  Leu Pro Thr 
    1010                 1015                 1020             


Gly Gln  Trp Val Gly Val Gln  Leu Pro Arg Asn Thr  Thr Ser Tyr 
    1025                 1030                 1035             


Val Leu  Arg Gly Leu Glu Pro  Gly Gln Glu Tyr Asn  Val Leu Leu 
    1040                 1045                 1050             


Thr Ala  Glu Lys Gly Arg His  Lys Ser Lys Pro Ala  Arg Val Lys 
    1055                 1060                 1065             


Ala Ser  Thr Glu Gln Ala Pro  Glu Leu Glu Asn Leu  Thr Val Thr 
    1070                 1075                 1080             


Glu Val  Gly Trp Asp Gly Leu  Arg Leu Asn Trp Thr  Ala Ala Asp 
    1085                 1090                 1095             


Gln Ala  Tyr Glu His Phe Ile  Ile Gln Val Gln Glu  Ala Asn Lys 
    1100                 1105                 1110             


Val Glu  Ala Ala Arg Asn Leu  Thr Val Pro Gly Ser  Leu Arg Ala 
    1115                 1120                 1125             


Val Asp  Ile Pro Gly Leu Lys  Ala Ala Thr Pro Tyr  Thr Val Ser 
    1130                 1135                 1140             


Ile Tyr  Gly Val Ile Gln Gly  Tyr Arg Thr Pro Val  Leu Ser Ala 
    1145                 1150                 1155             


Glu Ala  Ser Thr Gly Glu Thr  Pro Asn Leu Gly Glu  Val Val Val 
    1160                 1165                 1170             


Ala Glu  Val Gly Trp Asp Ala  Leu Lys Leu Asn Trp  Thr Ala Pro 
    1175                 1180                 1185             


Glu Gly  Ala Tyr Glu Tyr Phe  Phe Ile Gln Val Gln  Glu Ala Asp 
    1190                 1195                 1200             


Thr Val  Glu Ala Ala Gln Asn  Leu Thr Val Pro Gly  Gly Leu Arg 
    1205                 1210                 1215             


Ser Thr  Asp Leu Pro Gly Leu  Lys Ala Ala Thr His  Tyr Thr Ile 
    1220                 1225                 1230             


Thr Ile  Arg Gly Val Thr Gln  Asp Phe Ser Thr Thr  Pro Leu Ser 
    1235                 1240                 1245             


Val Glu  Val Leu Thr Glu Glu  Val Pro Asp Met Gly  Asn Leu Thr 
    1250                 1255                 1260             


Val Thr  Glu Val Ser Trp Asp  Ala Leu Arg Leu Asn  Trp Thr Thr 
    1265                 1270                 1275             


Pro Asp  Gly Thr Tyr Asp Gln  Phe Thr Ile Gln Val  Gln Glu Ala 
    1280                 1285                 1290             


Asp Gln  Val Glu Glu Ala His  Asn Leu Thr Val Pro  Gly Ser Leu 
    1295                 1300                 1305             


Arg Ser  Met Glu Ile Pro Gly  Leu Arg Ala Gly Thr  Pro Tyr Thr 
    1310                 1315                 1320             


Val Thr  Leu His Gly Glu Val  Arg Gly His Ser Thr  Arg Pro Leu 
    1325                 1330                 1335             


Ala Val  Glu Val Val Thr Glu  Asp Leu Pro Gln Leu  Gly Asp Leu 
    1340                 1345                 1350             


Ala Val  Ser Glu Val Gly Trp  Asp Gly Leu Arg Leu  Asn Trp Thr 
    1355                 1360                 1365             


Ala Ala  Asp Asn Ala Tyr Glu  His Phe Val Ile Gln  Val Gln Glu 
    1370                 1375                 1380             


Val Asn  Lys Val Glu Ala Ala  Gln Asn Leu Thr Leu  Pro Gly Ser 
    1385                 1390                 1395             


Leu Arg  Ala Val Asp Ile Pro  Gly Leu Glu Ala Ala  Thr Pro Tyr 
    1400                 1405                 1410             


Arg Val  Ser Ile Tyr Gly Val  Ile Arg Gly Tyr Arg  Thr Pro Val 
    1415                 1420                 1425             


Leu Ser  Ala Glu Ala Ser Thr  Ala Lys Glu Pro Glu  Ile Gly Asn 
    1430                 1435                 1440             


Leu Asn  Val Ser Asp Ile Thr  Pro Glu Ser Phe Asn  Leu Ser Trp 
    1445                 1450                 1455             


Met Ala  Thr Asp Gly Ile Phe  Glu Thr Phe Thr Ile  Glu Ile Ile 
    1460                 1465                 1470             


Asp Ser  Asn Arg Leu Leu Glu  Thr Val Glu Tyr Asn  Ile Ser Gly 
    1475                 1480                 1485             


Ala Glu  Arg Thr Ala His Ile  Ser Gly Leu Pro Pro  Ser Thr Asp 
    1490                 1495                 1500             


Phe Ile  Val Tyr Leu Ser Gly  Leu Ala Pro Ser Ile  Arg Thr Lys 
    1505                 1510                 1515             


Thr Ile  Ser Ala Thr Ala Thr  Thr Glu Ala Leu Pro  Leu Leu Glu 
    1520                 1525                 1530             


Asn Leu  Thr Ile Ser Asp Ile  Asn Pro Tyr Gly Phe  Thr Val Ser 
    1535                 1540                 1545             


Trp Met  Ala Ser Glu Asn Ala  Phe Asp Ser Phe Leu  Val Thr Val 
    1550                 1555                 1560             


Val Asp  Ser Gly Lys Leu Leu  Asp Pro Gln Glu Phe  Thr Leu Ser 
    1565                 1570                 1575             


Gly Thr  Gln Arg Lys Leu Glu  Leu Arg Gly Leu Ile  Thr Gly Ile 
    1580                 1585                 1590             


Gly Tyr  Glu Val Met Val Ser  Gly Phe Thr Gln Gly  His Gln Thr 
    1595                 1600                 1605             


Lys Pro  Leu Arg Ala Glu Ile  Val Thr Glu Ala Glu  Pro Glu Val 
    1610                 1615                 1620             


Asp Asn  Leu Leu Val Ser Asp  Ala Thr Pro Asp Gly  Phe Arg Leu 
    1625                 1630                 1635             


Ser Trp  Thr Ala Asp Glu Gly  Val Phe Asp Asn Phe  Val Leu Lys 
    1640                 1645                 1650             


Ile Arg  Asp Thr Lys Lys Gln  Ser Glu Pro Leu Glu  Ile Thr Leu 
    1655                 1660                 1665             


Leu Ala  Pro Glu Arg Thr Arg  Asp Ile Thr Gly Leu  Arg Glu Ala 
    1670                 1675                 1680             


Thr Glu  Tyr Glu Ile Glu Leu  Tyr Gly Ile Ser Lys  Gly Arg Arg 
    1685                 1690                 1695             


Ser Gln  Thr Val Ser Ala Ile  Ala Thr Thr Ala Met  Gly Ser Pro 
    1700                 1705                 1710             


Lys Glu  Val Ile Phe Ser Asp  Ile Thr Glu Asn Ser  Ala Thr Val 
    1715                 1720                 1725             


Ser Trp  Arg Ala Pro Thr Ala  Gln Val Glu Ser Phe  Arg Ile Thr 
    1730                 1735                 1740             


Tyr Val  Pro Ile Thr Gly Gly  Thr Pro Ser Met Val  Thr Val Asp 
    1745                 1750                 1755             


Gly Thr  Lys Thr Gln Thr Arg  Leu Val Lys Leu Ile  Pro Gly Val 
    1760                 1765                 1770             


Glu Tyr  Leu Val Ser Ile Ile  Ala Met Lys Gly Phe  Glu Glu Ser 
    1775                 1780                 1785             


Glu Pro  Val Ser Gly Ser Phe  Thr Thr Ala Leu Asp  Gly Pro Ser 
    1790                 1795                 1800             


Gly Leu  Val Thr Ala Asn Ile  Thr Asp Ser Glu Ala  Leu Ala Arg 
    1805                 1810                 1815             


Trp Gln  Pro Ala Ile Ala Thr  Val Asp Ser Tyr Val  Ile Ser Tyr 
    1820                 1825                 1830             


Thr Gly  Glu Lys Val Pro Glu  Ile Thr Arg Thr Val  Ser Gly Asn 
    1835                 1840                 1845             


Thr Val  Glu Tyr Ala Leu Thr  Asp Leu Glu Pro Ala  Thr Glu Tyr 
    1850                 1855                 1860             


Thr Leu  Arg Ile Phe Ala Glu  Lys Gly Pro Gln Lys  Ser Ser Thr 
    1865                 1870                 1875             


Ile Thr  Ala Lys Phe Thr Thr  Asp Leu Asp Ser Pro  Arg Asp Leu 
    1880                 1885                 1890             


Thr Ala  Thr Glu Val Gln Ser  Glu Thr Ala Leu Leu  Thr Trp Arg 
    1895                 1900                 1905             


Pro Pro  Arg Ala Ser Val Thr  Gly Tyr Leu Leu Val  Tyr Glu Ser 
    1910                 1915                 1920             


Val Asp  Gly Thr Val Lys Glu  Val Ile Val Gly Pro  Asp Thr Thr 
    1925                 1930                 1935             


Ser Tyr  Ser Leu Ala Asp Leu  Ser Pro Ser Thr His  Tyr Thr Ala 
    1940                 1945                 1950             


Lys Ile  Gln Ala Leu Asn Gly  Pro Leu Arg Ser Asn  Met Ile Gln 
    1955                 1960                 1965             


Thr Ile  Phe Thr Thr Ile Gly  Leu Leu Tyr Pro Phe  Pro Lys Asp 
    1970                 1975                 1980             


Cys Ser  Gln Ala Met Leu Asn  Gly Asp Thr Thr Ser  Gly Leu Tyr 
    1985                 1990                 1995             


Thr Ile  Tyr Leu Asn Gly Asp  Lys Ala Glu Ala Leu  Glu Val Phe 
    2000                 2005                 2010             


Cys Asp  Met Thr Ser Asp Gly  Gly Gly Trp Ile Val  Phe Leu Arg 
    2015                 2020                 2025             


Arg Lys  Asn Gly Arg Glu Asn  Phe Tyr Gln Asn Trp  Lys Ala Tyr 
    2030                 2035                 2040             


Ala Ala  Gly Phe Gly Asp Arg  Arg Glu Glu Phe Trp  Leu Gly Leu 
    2045                 2050                 2055             


Asp Asn  Leu Asn Lys Ile Thr  Ala Gln Gly Gln Tyr  Glu Leu Arg 
    2060                 2065                 2070             


Val Asp  Leu Arg Asp His Gly  Glu Thr Ala Phe Ala  Val Tyr Asp 
    2075                 2080                 2085             


Lys Phe  Ser Val Gly Asp Ala  Lys Thr Arg Tyr Lys  Leu Lys Val 
    2090                 2095                 2100             


Glu Gly  Tyr Ser Gly Thr Ala  Gly Asp Ser Met Ala  Tyr His Asn 
    2105                 2110                 2115             


Gly Arg  Ser Phe Ser Thr Phe  Asp Lys Asp Thr Asp  Ser Ala Ile 
    2120                 2125                 2130             


Thr Asn  Cys Ala Leu Ser Tyr  Lys Gly Ala Phe Trp  Tyr Arg Asn 
    2135                 2140                 2145             


Cys His  Arg Val Asn Leu Met  Gly Arg Tyr Gly Asp  Asn Asn His 
    2150                 2155                 2160             


Ser Gln  Gly Val Asn Trp Phe  His Trp Lys Gly His  Glu His Ser 
    2165                 2170                 2175             


Ile Gln  Phe Ala Glu Met Lys  Leu Arg Pro Ser Asn  Phe Arg Asn 
    2180                 2185                 2190             


Leu Glu  Gly Arg Arg Lys Arg  Ala 
    2195                 2200     


<210>  1154
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  1154

Met Ser Glu Thr Pro Ala Gln Cys Ser Ile Lys Gln Glu Arg Ile Ser 
1               5                   10                  15      


Tyr Thr Pro Pro Glu Ser Pro Val Pro Ser Tyr Ala Ser Ser Thr Pro 
            20                  25                  30          


Leu His Val Pro Val Pro Arg Ala Leu Arg Met Glu Glu Asp Ser Ile 
        35                  40                  45              


Arg Leu Pro Ala His Leu Arg Leu Gln Pro Ile Tyr Trp Ser Arg Asp 
    50                  55                  60                  


Asp Val Ala Gln Trp Leu Lys Trp Ala Glu Asn Glu Phe Ser Leu Arg 
65                  70                  75                  80  


Pro Ile Asp Ser Asn Thr Phe Glu Met Asn Gly Lys Ala Leu Leu Leu 
                85                  90                  95      


Leu Thr Lys Glu Asp Phe Arg Tyr Arg Ser Pro His Ser Gly Asp Val 
            100                 105                 110         


Leu Tyr Glu Leu Leu Gln His Ile Leu Lys Gln Arg Lys Pro Arg Ile 
        115                 120                 125             


Leu Phe Ser Pro Phe Phe His Pro Gly Asn Ser Ile His Thr Gln Pro 
    130                 135                 140                 


Glu Val Ile Leu His Gln Asn His Glu Glu Asp Asn Cys Val Gln Arg 
145                 150                 155                 160 


Thr Pro Arg Pro Ser Val Asp Asn Val His His Asn Pro Pro Thr Ile 
                165                 170                 175     


Glu Leu Leu His Arg Ser Arg Ser Pro Ile Thr Thr Asn His Arg Pro 
            180                 185                 190         


Ser Pro Asp Pro Glu Gln Arg Pro Leu Arg Ser Pro Leu Asp Asn Met 
        195                 200                 205             


Ile Arg Arg Leu Ser Pro Ala Glu Arg Ala Gln Gly Pro Arg Pro His 
    210                 215                 220                 


Gln Glu Asn Asn His Gln Glu Ser Tyr Pro Leu Ser Val Ser Pro Met 
225                 230                 235                 240 


Glu Asn Asn His Cys Pro Ala Ser Ser Glu Ser His Pro Lys Pro Ser 
                245                 250                 255     


Ser Pro Arg Gln Glu Ser Thr Arg Val Ile Gln Leu Met Pro Ser Pro 
            260                 265                 270         


Ile Met His Pro Leu Ile Leu Asn Pro Arg His Ser Val Asp Phe Lys 
        275                 280                 285             


Gln Ser Arg Leu Ser Glu Asp Gly Leu His Arg Glu Gly Lys Pro Ile 
    290                 295                 300                 


Asn Leu Ser His Arg Glu Asp Leu Ala Tyr Met Asn His Ile Met Val 
305                 310                 315                 320 


Ser Val Ser Pro Pro Glu Glu His Ala Met Pro Ile Gly Arg Ile Ala 
                325                 330                 335     


Asp Cys Arg Leu Leu Trp Asp Tyr Val Tyr Gln Leu Leu Ser Asp Ser 
            340                 345                 350         


Arg Tyr Glu Asn Phe Ile Arg Trp Glu Asp Lys Glu Ser Lys Ile Phe 
        355                 360                 365             


Arg Ile Val Asp Pro Asn Gly Leu Ala Arg Leu Trp Gly Asn His Lys 
    370                 375                 380                 


Asn Arg Thr Asn Met Thr Tyr Glu Lys Met Ser Arg Ala Leu Arg His 
385                 390                 395                 400 


Tyr Tyr Lys Leu Asn Ile Ile Arg Lys Glu Pro Gly Gln Arg Leu Leu 
                405                 410                 415     


Phe Arg Phe Met Lys Thr Pro Asp Glu Ile Met Ser Gly Arg Thr Asp 
            420                 425                 430         


Arg Leu Glu His Leu Glu Ser Gln Glu Leu Asp Glu Gln Ile Tyr Gln 
        435                 440                 445             


Glu Asp Glu Cys 
    450         


<210>  1155
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  1155

Met Cys Lys Gly Leu Ala Ala Leu Pro His Ser Cys Leu Glu Arg Ala 
1               5                   10                  15      


Lys Glu Ile Lys Ile Lys Leu Gly Ile Leu Leu Gln Lys Pro Asp Ser 
            20                  25                  30          


Val Gly Asp Leu Val Ile Pro Tyr Asn Glu Lys Pro Glu Lys Pro Ala 
        35                  40                  45              


Lys Thr Gln Lys Thr Ser Leu Asp Glu Ala Leu Gln Trp Arg Asp Ser 
    50                  55                  60                  


Leu Asp Lys Leu Leu Gln Asn Asn Tyr Gly Leu Ala Ser Phe Lys Ser 
65                  70                  75                  80  


Phe Leu Lys Ser Glu Phe Ser Glu Glu Asn Leu Glu Phe Trp Ile Ala 
                85                  90                  95      


Cys Glu Asp Tyr Lys Lys Ile Lys Ser Pro Ala Lys Met Ala Glu Lys 
            100                 105                 110         


Ala Lys Gln Ile Tyr Glu Glu Phe Ile Gln Thr Glu Ala Pro Lys Glu 
        115                 120                 125             


Val Asn Ile Asp His Phe Thr Lys Asp Ile Thr Met Lys Asn Leu Val 
    130                 135                 140                 


Glu Pro Ser Leu Ser Ser Phe Asp Met Ala Gln Lys Arg Ile His Ala 
145                 150                 155                 160 


Leu Met Glu Lys Asp Ser Leu Pro Arg Phe Val Arg Ser Glu Phe Tyr 
                165                 170                 175     


Gln Glu Leu Ile Lys 
            180     


<210>  1156
<211>  963
<212>  PRT
<213>  Homo sapiens

<400>  1156

Met Ala Thr Ala Ala Glu Thr Ser Ala Ser Glu Pro Glu Ala Glu Ser 
1               5                   10                  15      


Lys Ala Gly Pro Lys Ala Asp Gly Glu Glu Asp Glu Val Lys Ala Ala 
            20                  25                  30          


Arg Thr Arg Arg Lys Val Leu Ser Arg Ala Val Ala Ala Ala Thr Tyr 
        35                  40                  45              


Lys Thr Met Gly Pro Ala Trp Asp Gln Gln Glu Glu Gly Val Ser Glu 
    50                  55                  60                  


Ser Asp Gly Asp Glu Tyr Ala Met Ala Ser Ser Ala Glu Ser Ser Pro 
65                  70                  75                  80  


Gly Glu Tyr Glu Trp Glu Tyr Asp Glu Glu Glu Glu Lys Asn Gln Leu 
                85                  90                  95      


Glu Ile Glu Arg Leu Glu Glu Gln Leu Ser Ile Asn Val Tyr Asp Tyr 
            100                 105                 110         


Asn Cys His Val Asp Leu Ile Arg Leu Leu Arg Leu Glu Gly Glu Leu 
        115                 120                 125             


Thr Lys Val Arg Met Ala Arg Gln Lys Met Ser Glu Ile Phe Pro Leu 
    130                 135                 140                 


Thr Glu Glu Leu Trp Leu Glu Trp Leu His Asp Glu Ile Ser Met Ala 
145                 150                 155                 160 


Gln Asp Gly Leu Asp Arg Glu His Val Tyr Asp Leu Phe Glu Lys Ala 
                165                 170                 175     


Val Lys Asp Tyr Ile Cys Pro Asn Ile Trp Leu Glu Tyr Gly Gln Tyr 
            180                 185                 190         


Ser Val Gly Gly Ile Gly Gln Lys Gly Gly Leu Glu Lys Val Arg Ser 
        195                 200                 205             


Val Phe Glu Arg Ala Leu Ser Ser Val Gly Leu His Met Thr Lys Gly 
    210                 215                 220                 


Leu Ala Leu Trp Glu Ala Tyr Arg Glu Phe Glu Ser Ala Ile Val Glu 
225                 230                 235                 240 


Ala Ala Arg Leu Glu Lys Val His Ser Leu Phe Arg Arg Gln Leu Ala 
                245                 250                 255     


Ile Pro Leu Tyr Asp Met Glu Ala Thr Phe Ala Glu Tyr Glu Glu Trp 
            260                 265                 270         


Ser Glu Asp Pro Ile Pro Glu Ser Val Ile Gln Asn Tyr Asn Lys Ala 
        275                 280                 285             


Leu Gln Gln Leu Glu Lys Tyr Lys Pro Tyr Glu Glu Ala Leu Leu Gln 
    290                 295                 300                 


Ala Glu Ala Pro Arg Leu Ala Glu Tyr Gln Ala Tyr Ile Asp Phe Glu 
305                 310                 315                 320 


Met Lys Ile Gly Asp Pro Ala Arg Ile Gln Leu Ile Phe Glu Arg Ala 
                325                 330                 335     


Leu Val Glu Asn Cys Leu Val Pro Asp Leu Trp Ile Arg Tyr Ser Gln 
            340                 345                 350         


Tyr Leu Asp Arg Gln Leu Lys Val Lys Asp Leu Val Leu Ser Val His 
        355                 360                 365             


Asn Arg Ala Ile Arg Asn Cys Pro Trp Thr Val Ala Leu Trp Ser Arg 
    370                 375                 380                 


Tyr Leu Leu Ala Met Glu Arg His Gly Val Asp His Gln Val Ile Ser 
385                 390                 395                 400 


Val Thr Phe Glu Lys Ala Leu Asn Ala Gly Phe Ile Gln Ala Thr Asp 
                405                 410                 415     


Tyr Val Glu Ile Trp Gln Ala Tyr Leu Asp Tyr Leu Arg Arg Arg Val 
            420                 425                 430         


Asp Phe Lys Gln Asp Ser Ser Lys Glu Leu Glu Glu Leu Arg Ala Ala 
        435                 440                 445             


Phe Thr Arg Ala Leu Glu Tyr Leu Lys Gln Glu Val Glu Glu Arg Phe 
    450                 455                 460                 


Asn Glu Ser Gly Asp Pro Ser Cys Val Ile Met Gln Asn Trp Ala Arg 
465                 470                 475                 480 


Ile Glu Ala Arg Leu Cys Asn Asn Met Gln Lys Ala Arg Glu Leu Trp 
                485                 490                 495     


Asp Ser Ile Met Thr Arg Gly Asn Ala Lys Tyr Ala Asn Met Trp Leu 
            500                 505                 510         


Glu Tyr Tyr Asn Leu Glu Arg Ala His Gly Asp Thr Gln His Cys Arg 
        515                 520                 525             


Lys Ala Leu His Arg Ala Val Gln Cys Thr Ser Asp Tyr Pro Glu His 
    530                 535                 540                 


Val Cys Glu Val Leu Leu Thr Met Glu Arg Thr Glu Gly Ser Leu Glu 
545                 550                 555                 560 


Asp Trp Asp Ile Ala Val Gln Lys Thr Glu Thr Arg Leu Ala Arg Val 
                565                 570                 575     


Asn Glu Gln Arg Met Lys Ala Ala Glu Lys Glu Ala Ala Leu Val Gln 
            580                 585                 590         


Gln Glu Glu Glu Lys Ala Glu Gln Arg Lys Arg Ala Arg Ala Glu Lys 
        595                 600                 605             


Lys Ala Leu Lys Lys Lys Lys Lys Ile Arg Gly Pro Glu Lys Arg Gly 
    610                 615                 620                 


Ala Asp Glu Asp Asp Glu Lys Glu Trp Gly Asp Asp Glu Glu Glu Gln 
625                 630                 635                 640 


Pro Ser Lys Arg Arg Arg Val Glu Asn Ser Ile Pro Ala Ala Gly Glu 
                645                 650                 655     


Thr Gln Asn Val Glu Val Ala Ala Gly Pro Ala Gly Lys Cys Ala Ala 
            660                 665                 670         


Val Asp Val Glu Pro Pro Ser Lys Gln Lys Glu Lys Ala Ala Ser Leu 
        675                 680                 685             


Lys Arg Asp Met Pro Lys Val Leu His Asp Ser Ser Lys Asp Ser Ile 
    690                 695                 700                 


Thr Val Phe Val Ser Asn Leu Pro Tyr Ser Met Gln Glu Pro Asp Thr 
705                 710                 715                 720 


Lys Leu Arg Pro Leu Phe Glu Ala Cys Gly Glu Val Val Gln Ile Arg 
                725                 730                 735     


Pro Ile Phe Ser Asn Arg Gly Asp Phe Arg Gly Tyr Cys Tyr Val Glu 
            740                 745                 750         


Phe Lys Glu Glu Lys Ser Ala Leu Gln Ala Leu Glu Met Asp Arg Lys 
        755                 760                 765             


Ser Val Glu Gly Arg Pro Met Phe Val Ser Pro Cys Val Asp Lys Ser 
    770                 775                 780                 


Lys Asn Pro Asp Phe Lys Val Phe Arg Tyr Ser Thr Ser Leu Glu Lys 
785                 790                 795                 800 


His Lys Leu Phe Ile Ser Gly Leu Pro Phe Ser Cys Thr Lys Glu Glu 
                805                 810                 815     


Leu Glu Glu Ile Cys Lys Ala His Gly Thr Val Lys Asp Leu Arg Leu 
            820                 825                 830         


Val Thr Asn Arg Ala Gly Lys Pro Lys Gly Leu Ala Tyr Val Glu Tyr 
        835                 840                 845             


Glu Asn Glu Ser Gln Ala Ser Gln Ala Val Met Lys Met Asp Gly Met 
    850                 855                 860                 


Thr Ile Lys Glu Asn Ile Ile Lys Val Ala Ile Ser Asn Pro Pro Gln 
865                 870                 875                 880 


Arg Lys Val Pro Glu Lys Pro Glu Thr Arg Lys Ala Pro Gly Gly Pro 
                885                 890                 895     


Met Leu Leu Pro Gln Thr Tyr Gly Ala Arg Gly Lys Gly Arg Thr Gln 
            900                 905                 910         


Leu Ser Leu Leu Pro Arg Ala Leu Gln Arg Pro Ser Ala Ala Ala Pro 
        915                 920                 925             


Gln Ala Glu Asn Gly Pro Ala Ala Ala Pro Ala Val Ala Ala Pro Ala 
    930                 935                 940                 


Ala Thr Glu Ala Pro Lys Met Ser Asn Ala Asp Phe Ala Lys Leu Phe 
945                 950                 955                 960 


Leu Arg Lys 
            


<210>  1157
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  1157

Met Leu Ile Leu Leu Ser Arg Tyr His Trp Gln Pro Asp Ser Lys Asp 
1               5                   10                  15      


Arg Ala Phe Thr Leu Asn Thr Phe His Leu Asn Arg Ala Ala Met Leu 
            20                  25                  30          


Phe Asp Asp Ile Leu His His Ser Gln Pro Gln Ala Cys Pro Val Ser 
        35                  40                  45              


Phe Gly Arg Lys Ile Arg Arg Lys Asn Arg Leu Gln Leu Ile Arg Gly 
    50                  55                  60                  


Asp Pro Phe Pro Ala Ile Gly Asn Ser Asp Asp Asn Ala Val Gly Pro 
65                  70                  75                  80  


Thr Phe Phe Cys Leu Tyr Ala Asn Arg Ser Leu Ala Ala Asn Arg Met 
                85                  90                  95      


Asn Ser Val Gln Val Gln Ile Gln Gln His Leu Ser Gln Pro Val Arg 
            100                 105                 110         


Val Ser Leu Asn Thr Leu Lys Arg Leu Ile Arg Arg Glu Ser Gln Leu 
        115                 120                 125             


Asn Leu Ser Ala Leu Gly Ile Leu Thr Asp Gln Ile Gln Gly Val Ser 
    130                 135                 140                 


Asn Asn Ile Ile Glu Val Asn Arg Leu Glu Arg Gln Met Arg Gly Leu 
145                 150                 155                 160 


Tyr Gln Phe Glu Gln Phe Ala Tyr His Pro Val Gln Thr Val Gly Leu 
                165                 170                 175     


Phe Gly His His Leu Arg Gln Phe Met Arg Leu Ala Ala Gly Arg Arg 
            180                 185                 190         


Ala Leu Gly Lys Val Phe Arg Gln Pro Phe Asp Gly Arg Glu Arg Val 
        195                 200                 205             


Thr Asn Phe Val Arg Asp Ala Arg Arg Gln Met Pro His Arg His Gln 
    210                 215                 220                 


Leu Phe Phe Thr Leu His Cys Ile Lys Gln Phe Ser Val Arg Ala Leu 
225                 230                 235                 240 


Ile Thr Leu Met Pro Lys Lys Arg Gln 
                245                 


<210>  1158
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  1158

Met Asp Leu Glu Lys Asn Tyr Pro Thr Pro Arg Thr Ser Arg Thr Gly 
1               5                   10                  15      


His Gly Gly Val Asn Gln Leu Gly Gly Val Phe Val Asn Gly Arg Pro 
            20                  25                  30          


Leu Pro Asp Val Val Arg Gln Arg Ile Val Glu Leu Ala His Gln Gly 
        35                  40                  45              


Val Arg Pro Cys Asp Ile Ser Arg Gln Leu Arg Val Ser His Gly Cys 
    50                  55                  60                  


Val Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly Ser Ile Lys Pro 
65                  70                  75                  80  


Gly Val Ile Gly Gly Ser Lys Pro Lys Val Ala Thr Pro Lys Val Val 
                85                  90                  95      


Glu Lys Ile Ala Glu Tyr Lys Arg Gln Asn Pro Thr Met Phe Ala Trp 
            100                 105                 110         


Glu Ile Arg Asp Arg Leu Leu Ala Glu Arg Val Cys Asp Asn Asp Thr 
        115                 120                 125             


Val Pro Ser Val Ser Ser Ile Asn Arg Ile Ile Arg Thr Lys Val Gln 
    130                 135                 140                 


Gln Pro Pro Asn Gln Pro Val Pro Ala Ser Ser His Ser Ile Val Ser 
145                 150                 155                 160 


Thr Gly Ser Val Thr Gln Val Ser Ser Val Ser Thr Asp Ser Ala Gly 
                165                 170                 175     


Ser Ser Tyr Ser Ile Ser Gly Ile Leu Gly Ile Thr Ser Pro Ser Ala 
            180                 185                 190         


Asp Thr Asn Lys Arg Lys Arg Asp Glu Gly Ile Gln Glu Ser Pro Val 
        195                 200                 205             


Pro Asn Gly His Ser Leu Pro Gly Arg Asp Phe Leu Arg Lys Gln Met 
    210                 215                 220                 


Arg Gly Asp Leu Phe Thr Gln Gln Gln Leu Glu Val Leu Asp Arg Val 
225                 230                 235                 240 


Phe Glu Arg Gln His Tyr Ser Asp Ile Phe Thr Thr Thr Glu Pro Ile 
                245                 250                 255     


Lys Pro Glu Gln Thr Thr Glu Tyr Ser Ala Met Ala Ser Leu Ala Gly 
            260                 265                 270         


Gly Leu Asp Asp Met Lys Ala Asn Leu Ala Ser Pro Thr Pro Ala Asp 
        275                 280                 285             


Ile Gly Ser Ser Val Pro Gly Pro Gln Ser Tyr Pro Ile Val Thr Gly 
    290                 295                 300                 


Arg Asp Leu Ala Ser Thr Thr Leu Pro Gly Tyr Pro Pro His Val Pro 
305                 310                 315                 320 


Pro Ala Gly Gln Gly Ser Tyr Ser Ala Pro Thr Leu Thr Gly Met Val 
                325                 330                 335     


Pro Gly Ser Glu Phe Ser Gly Ser Pro Tyr Ser His Pro Gln Tyr Ser 
            340                 345                 350         


Ser Tyr Asn Asp Ser Trp Arg Phe Pro Asn Pro Gly Leu Leu Gly Ser 
        355                 360                 365             


Pro Tyr Tyr Tyr Ser Ala Ala Ala Arg Gly Ala Ala Pro Pro Ala Ala 
    370                 375                 380                 


Ala Thr Ala Tyr Asp Arg His 
385                 390     


<210>  1159
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  1159

Met Gln Ala Glu Gly Arg Gly Thr Gly Gly Ser Thr Gly Asp Ala Asp 
1               5                   10                  15      


Gly Pro Gly Gly Pro Gly Ile Pro Asp Gly Pro Gly Gly Asn Ala Gly 
            20                  25                  30          


Gly Pro Gly Glu Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala 
        35                  40                  45              


Gly Ala Ala Arg Ala Ser Gly Pro Gly Gly Gly Ala Pro Arg Gly Pro 
    50                  55                  60                  


His Gly Gly Ala Ala Ser Gly Leu Asn Gly Cys Cys Arg Cys Gly Ala 
65                  70                  75                  80  


Arg Gly Pro Glu Ser Arg Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe 
                85                  90                  95      


Ala Thr Pro Met Glu Ala Glu Leu Ala Arg Arg Ser Leu Ala Gln Asp 
            100                 105                 110         


Ala Pro Pro Leu Pro Val Pro Gly Val Leu Leu Lys Glu Phe Thr Val 
        115                 120                 125             


Ser Gly Asn Ile Leu Thr Ile Arg Leu Thr Ala Ala Asp His Arg Gln 
    130                 135                 140                 


Leu Gln Leu Ser Ile Ser Ser Cys Leu Gln Gln Leu Ser Leu Leu Met 
145                 150                 155                 160 


Trp Ile Thr Gln Cys Phe Leu Pro Val Phe Leu Ala Gln Pro Pro Ser 
                165                 170                 175     


Gly Gln Arg Arg 
            180 


<210>  1160
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  1160

Met Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly 
            20                  25                  30          


Lys Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn 
    50                  55                  60                  


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
65                  70                  75                  80  


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
                85                  90                  95      


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
            100                 105                 110         


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
        115                 120                 125             


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
    130                 135                 140                 


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
                165                 170                 175     


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
            180                 185                 190         


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val Arg His 
        195                 200                 205             


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Arg Leu Ser Arg Pro Cys 
    210                 215                 220                 


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
225                 230                 235                 240 


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe 
                245                 250                 255     


Gly Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val 
            260                 265                 270         


Lys Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu 
        275                 280                 285             


Ala Asn Leu Met Lys Gln Leu Gln His Gln Arg Leu Val Arg Leu Tyr 
    290                 295                 300                 


Ala Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Glu 
305                 310                 315                 320 


Asn Gly Ser Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu 
                325                 330                 335     


Thr Ile Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met 
            340                 345                 350         


Ala Phe Ile Glu Glu Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
        355                 360                 365             


Asn Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly 
    370                 375                 380                 


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
385                 390                 395                 400 


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr 
                405                 410                 415     


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu 
            420                 425                 430         


Ile Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu 
        435                 440                 445             


Val Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn 
    450                 455                 460                 


Cys Pro Glu Glu Leu Tyr Gln Leu Met Arg Leu Cys Trp Lys Glu Arg 
465                 470                 475                 480 


Pro Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Glu Asp 
                485                 490                 495     


Phe Phe Thr Ala Thr Glu Gly Gln Tyr Gln Pro Gln Pro 
            500                 505                 


<210>  1161
<211>  854
<212>  PRT
<213>  Homo sapiens

<400>  1161

Met Met Ala Tyr Ser Asp Thr Thr Met Met Ser Asp Asp Ile Asp Trp 
1               5                   10                  15      


Leu Arg Ser His Arg Gly Val Cys Lys Val Asp Leu Tyr Asn Pro Glu 
            20                  25                  30          


Gly Gln Gln Asp Gln Asp Arg Lys Val Ile Cys Phe Val Asp Val Ser 
        35                  40                  45              


Thr Leu Asn Val Glu Asp Lys Asp Tyr Lys Asp Ala Ala Ser Ser Ser 
    50                  55                  60                  


Ser Glu Gly Asn Leu Asn Leu Gly Ser Leu Glu Glu Lys Glu Ile Ile 
65                  70                  75                  80  


Val Ile Lys Asp Thr Glu Lys Lys Asp Gln Ser Lys Thr Glu Gly Ser 
                85                  90                  95      


Val Cys Leu Phe Lys Gln Ala Pro Ser Asp Pro Val Ser Val Leu Asn 
            100                 105                 110         


Trp Leu Leu Ser Asp Leu Gln Lys Tyr Ala Leu Gly Phe Gln His Ala 
        115                 120                 125             


Leu Ser Pro Ser Thr Ser Thr Cys Lys His Lys Val Gly Asp Thr Glu 
    130                 135                 140                 


Gly Glu Tyr His Arg Ala Ser Ser Glu Asn Cys Tyr Ser Val Tyr Ala 
145                 150                 155                 160 


Asp Gln Val Asn Ile Asp Tyr Leu Met Asn Arg Pro Gln Asn Leu Arg 
                165                 170                 175     


Leu Glu Met Thr Ala Ala Lys Asn Thr Asn Asn Asn Gln Ser Pro Ser 
            180                 185                 190         


Ala Pro Pro Ala Lys Pro Pro Ser Thr Gln Arg Ala Val Ile Ser Pro 
        195                 200                 205             


Asp Gly Glu Cys Ser Ile Asp Asp Leu Ser Phe Tyr Val Asn Arg Leu 
    210                 215                 220                 


Ser Ser Leu Val Ile Gln Met Ala His Lys Glu Ile Lys Glu Lys Leu 
225                 230                 235                 240 


Glu Gly Lys Ser Lys Cys Leu His His Ser Ile Cys Pro Ser Pro Gly 
                245                 250                 255     


Asn Lys Glu Arg Ile Ser Pro Arg Thr Pro Ala Ser Lys Ile Ala Ser 
            260                 265                 270         


Glu Met Ala Tyr Glu Ala Val Glu Leu Thr Ala Ala Glu Met Arg Gly 
        275                 280                 285             


Thr Gly Glu Glu Ser Arg Glu Gly Gly Gln Lys Ser Phe Leu Tyr Ser 
    290                 295                 300                 


Glu Leu Ser Asn Lys Ser Lys Ser Gly Asp Lys Gln Met Ser Gln Arg 
305                 310                 315                 320 


Glu Ser Lys Glu Phe Ala Asp Ser Ile Ser Lys Gly Leu Met Val Tyr 
                325                 330                 335     


Ala Asn Gln Val Ala Ser Asp Met Met Val Ser Leu Met Lys Thr Leu 
            340                 345                 350         


Lys Val His Ser Ser Gly Lys Pro Ile Pro Ala Ser Val Val Leu Lys 
        355                 360                 365             


Arg Val Leu Leu Arg His Thr Lys Glu Ile Val Ser Asp Leu Ile Asp 
    370                 375                 380                 


Ser Cys Met Lys Asn Leu His Asn Ile Thr Gly Val Leu Met Thr Asp 
385                 390                 395                 400 


Ser Asp Phe Val Ser Ala Val Lys Arg Asn Leu Phe Asn Gln Trp Lys 
                405                 410                 415     


Gln Asn Ala Thr Asp Ile Met Glu Ala Met Leu Lys Arg Leu Val Ser 
            420                 425                 430         


Ala Leu Ile Gly Glu Glu Lys Glu Thr Lys Ser Gln Ser Leu Ser Tyr 
        435                 440                 445             


Ala Ser Leu Lys Ala Gly Ser His Asp Pro Lys Cys Arg Asn Gln Ser 
    450                 455                 460                 


Leu Glu Phe Ser Thr Met Lys Ala Glu Met Lys Glu Arg Asp Lys Gly 
465                 470                 475                 480 


Lys Met Lys Ser Asp Pro Cys Lys Ser Leu Thr Ser Ala Glu Lys Val 
                485                 490                 495     


Gly Glu His Ile Leu Lys Glu Gly Leu Thr Ile Trp Asn Gln Lys Gln 
            500                 505                 510         


Gly Asn Ser Cys Lys Val Ala Thr Lys Ala Cys Ser Asn Lys Asp Glu 
        515                 520                 525             


Lys Gly Glu Lys Ile Asn Ala Ser Thr Asp Ser Leu Ala Lys Asp Leu 
    530                 535                 540                 


Ile Val Ser Ala Leu Lys Leu Ile Gln Tyr His Leu Thr Gln Gln Thr 
545                 550                 555                 560 


Lys Gly Lys Asp Thr Cys Glu Glu Asp Cys Pro Gly Ser Thr Met Gly 
                565                 570                 575     


Tyr Met Ala Gln Ser Thr Gln Tyr Glu Lys Cys Gly Gly Gly Gln Ser 
            580                 585                 590         


Ala Lys Ala Leu Ser Val Lys Gln Leu Glu Ser His Arg Ala Pro Gly 
        595                 600                 605             


Pro Ser Thr Cys Gln Lys Glu Asn Gln His Leu Asp Ser Gln Lys Met 
    610                 615                 620                 


Asp Met Ser Asn Ile Val Leu Met Leu Ile Gln Lys Leu Leu Asn Glu 
625                 630                 635                 640 


Asn Pro Phe Lys Cys Glu Asp Pro Cys Glu Gly Glu Asn Lys Cys Ser 
                645                 650                 655     


Glu Pro Arg Ala Ser Lys Ala Ala Ser Met Ser Asn Arg Ser Asp Lys 
            660                 665                 670         


Ala Glu Glu Gln Cys Gln Glu His Gln Glu Leu Asp Cys Thr Ser Gly 
        675                 680                 685             


Met Lys Gln Ala Asn Gly Gln Phe Ile Asp Lys Leu Val Glu Ser Val 
    690                 695                 700                 


Met Lys Leu Cys Leu Ile Met Ala Lys Tyr Ser Asn Asp Gly Ala Ala 
705                 710                 715                 720 


Leu Ala Glu Leu Glu Glu Gln Ala Ala Ser Ala Asn Lys Pro Asn Phe 
                725                 730                 735     


Arg Gly Thr Arg Cys Ile His Ser Gly Ala Met Pro Gln Asn Tyr Gln 
            740                 745                 750         


Asp Ser Leu Gly His Glu Val Ile Val Asn Asn Gln Cys Ser Thr Asn 
        755                 760                 765             


Ser Leu Gln Lys Gln Leu Gln Ala Val Leu Gln Trp Ile Ala Ala Ser 
    770                 775                 780                 


Gln Phe Asn Val Pro Met Leu Tyr Phe Met Gly Asp Lys Asp Gly Gln 
785                 790                 795                 800 


Leu Glu Lys Leu Pro Gln Val Ser Ala Lys Ala Ala Glu Lys Gly Tyr 
                805                 810                 815     


Ser Val Gly Gly Leu Leu Gln Glu Val Met Lys Phe Ala Lys Glu Arg 
            820                 825                 830         


Gln Pro Asp Glu Ala Val Gly Lys Val Ala Arg Lys Gln Leu Leu Asp 
        835                 840                 845             


Trp Leu Leu Ala Asn Leu 
    850                 


<210>  1162
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  1162

Met Glu Ser Pro Lys Lys Lys Asn Gln Gln Leu Lys Val Gly Ile Leu 
1               5                   10                  15      


His Leu Gly Ser Arg Gln Lys Lys Ile Arg Ile Gln Leu Arg Ser Gln 
            20                  25                  30          


Cys Ala Thr Trp Lys Val Ile Cys Lys Ser Cys Ile Ser Gln Thr Pro 
        35                  40                  45              


Gly Ile Asn Leu Asp Leu Gly Ser Gly Val Lys Val Lys Ile Ile Pro 
    50                  55                  60                  


Lys Glu Glu His Cys Lys Met Pro Glu Ala Gly Glu Glu Gln Pro Gln 
65                  70                  75                  80  


Val 
    


<210>  1163
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  1163

Met Leu Arg Gly Trp Gly Gly Pro Ser Val Gly Val Cys Val Arg Thr 
1               5                   10                  15      


Ala Leu Gly Val Leu Cys Leu Cys Leu Thr Gly Ala Val Glu Val Gln 
            20                  25                  30          


Val Ser Glu Asp Pro Val Val Ala Leu Val Asp Thr Asp Ala Thr Leu 
        35                  40                  45              


Arg Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn 
    50                  55                  60                  


Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Thr 
65                  70                  75                  80  


Glu Gly Arg Asp Gln Gly Ser Ala Tyr Ser Asn Arg Thr Ala Leu Phe 
                85                  90                  95      


Pro Asp Leu Leu Val Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val 
            100                 105                 110         


Arg Val Thr Asp Glu Gly Ser Tyr Thr Cys Phe Val Ser Ile Gln Asp 
        115                 120                 125             


Phe Asp Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys 
    130                 135                 140                 


Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asn Met 
145                 150                 155                 160 


Val Thr Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro Glu Ala Glu Val 
                165                 170                 175     


Phe Trp Lys Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr 
            180                 185                 190         


Ser Gln Met Ala Asn Glu Arg Gly Leu Phe Asp Val His Ser Val Leu 
        195                 200                 205             


Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn 
    210                 215                 220                 


Pro Val Leu Gln Gln Asp Ala His Gly Ser Val Thr Ile Thr Gly Gln 
225                 230                 235                 240 


Pro Leu Thr Phe Pro Pro Glu Ala Leu Trp Val Thr Val Gly Leu Ser 
                245                 250                 255     


Val Cys Leu Val Val Leu Leu Val Ala Leu Ala Phe Val Cys Trp Arg 
            260                 265                 270         


Lys Ile Lys Gln Ser Cys Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln 
        275                 280                 285             


Asp Gly Asp Gly Glu Gly Ser Lys Thr Ala Leu Arg Pro Leu Lys Pro 
    290                 295                 300                 


Ser Glu Asn Lys Glu Asp Asp Gly Gln Glu Ile Ala 
305                 310                 315     


<210>  1164
<211>  78
<212>  PRT
<213>  Homo sapiens

<400>  1164

Met Val Trp Lys Val Ala Val Phe Leu Ser Val Ala Leu Gly Ile Gly 
1               5                   10                  15      


Ala Val Pro Ile Asp Asp Pro Glu Asp Gly Gly Lys His Trp Val Val 
            20                  25                  30          


Ile Val Ala Gly Ser Asn Gly Trp Tyr Asn Tyr Arg His Gln Ala Asp 
        35                  40                  45              


Ala Cys His Ala Tyr Gln Ile Ile His Arg Asn Gly Ile Pro Asp Glu 
    50                  55                  60                  


Gln Ile Val Val Met Met Tyr Asp Asp Ile Ala Tyr Ser Glu 
65                  70                  75              


<210>  1165
<211>  1116
<212>  PRT
<213>  Homo sapiens

<400>  1165

Met Cys Leu Leu Asp Ser Cys Thr Ala Leu Leu Leu Leu Gly Cys Trp 
1               5                   10                  15      


Met Ser Gly Ser Ala Val Arg Ile Ser Asp Val Thr Leu Val Asn Pro 
            20                  25                  30          


Asp Pro Val Val Ser Pro Leu Thr Ala Pro Ser Leu Leu Cys Val Ser 
        35                  40                  45              


Ser Asp Trp Ser Ser Gly Gly Ser Val Leu Ala Leu Gly Gln Glu Phe 
    50                  55                  60                  


Pro Arg Pro Gln Gly Ser Val Leu Ala Leu Gly Gln Glu Phe Pro His 
65                  70                  75                  80  


Thr Glu Pro Arg Pro His Pro Ala Ala Ala Thr Val Thr Trp Ser Ser 
                85                  90                  95      


Arg Ser His Ala Phe Gly Ala Phe Tyr Cys Gln Ile Arg Asn Ser Thr 
            100                 105                 110         


Gly Arg Lys Ile Tyr Thr Tyr Lys Met Leu Gln Glu Ala Ala Phe Leu 
        115                 120                 125             


Pro Glu Ser Leu Thr Ile Thr Val Asn Gln Gly Glu Asn Ile Asn Ile 
    130                 135                 140                 


Ser Tyr Ser Arg Arg Leu Tyr Ser Pro Glu Asp Thr Val Ile His Lys 
145                 150                 155                 160 


Asn Gly His Phe Glu His Ser Ser Pro Lys Glu Asp Ile Ser Asp Ile 
                165                 170                 175     


Ile His Tyr Pro Val Thr Asn Ala Lys Ala Glu Ser His Ala Gly Ile 
            180                 185                 190         


Tyr Ala Ile Arg Tyr Ile Ser Ala Ala Pro Ser Ser Ala Ala Ile Thr 
        195                 200                 205             


Arg Leu Ile Val Arg Ser Cys Arg Ala Gly Phe Trp Gly Pro Asn Cys 
    210                 215                 220                 


Thr Glu Ser Cys Pro Arg Cys Ala Asn Gly Gly Val Cys Asp Asp Thr 
225                 230                 235                 240 


Thr Gly Glu Cys Val Cys Pro Pro Gly Phe Arg Gly His Thr Cys Asp 
                245                 250                 255     


Ile Val Cys Gly Glu Gly Arg Phe Gly Ala Gly Cys Lys Glu Arg Cys 
            260                 265                 270         


Val Asp Gly Val Cys Arg Ala Leu Val Phe Cys Leu Arg Asp Pro Tyr 
        275                 280                 285             


Gly Cys Ser Cys Ala Ser Gly Trp Arg Gly Leu Ser Cys Asn Asp Ala 
    290                 295                 300                 


Cys Pro Asp Gly Tyr Tyr Gly Ala Gly Cys Thr Gln Lys Cys Val Cys 
305                 310                 315                 320 


Ala Lys Gly Arg Cys Asp Arg Phe Arg Gly Cys Val Cys Ala Gly Arg 
                325                 330                 335     


His Gly Ser Arg Cys Glu Glu Ala Asp Ser Ser Pro Val Ile Ser His 
            340                 345                 350         


Leu Arg Asp Val Glu Ile Asn Thr Gly Val Glu Leu Ser Val Asn Cys 
        355                 360                 365             


Ser Ala Ser Gly Arg Pro Ala Pro Leu His Gly Asp Ile Thr Leu Ile 
    370                 375                 380                 


Thr Ala Asn Arg Thr Thr Ile Ala Ala Val Asp Thr His Thr Leu Asn 
385                 390                 395                 400 


Asp Gln Ser Thr Ser Val Phe Arg Val Gln Gln Val Arg Val Ser Ser 
                405                 410                 415     


Ala Gly Arg Trp Arg Cys Gln Val Asn Asn Thr His Met Gln Val Glu 
            420                 425                 430         


Asp Glu Phe Thr Val Glu Val Lys Val Pro Pro Arg Pro Gln Asn Pro 
        435                 440                 445             


Pro Val Leu Gln Gly Ser Gly Pro Arg His Leu Leu Leu Leu Leu Asn 
    450                 455                 460                 


Thr Glu Pro Tyr Ser Gly Asp Gly Pro Ile Ala Thr Thr Thr Leu Leu 
465                 470                 475                 480 


Tyr Arg Pro Ala Ser Ala His Thr Trp Ser Ser Val Thr Ala His Gly 
                485                 490                 495     


Pro Leu Val Arg Leu Asp Asn Leu Tyr Pro Met Thr Gln Tyr Leu Thr 
            500                 505                 510         


Gln Val Gln Leu Ser Arg Pro Gly Pro Gly Gly Ala Gly Gln Ala Gly 
        515                 520                 525             


Pro Ala Ala Thr Phe Ser Thr Gln Val Leu Glu Leu Pro Val Gly Val 
    530                 535                 540                 


Lys Leu Ser Ala Val Ser Gln Thr Ala Leu Leu Leu Ser Trp Asp Ile 
545                 550                 555                 560 


Ala Pro Ala Glu Gln His Cys Thr Tyr Glu Val Ser Cys Leu Gln Ala 
                565                 570                 575     


Gly Ala Pro Gly Thr Leu Arg Thr Phe Gln Leu Pro Ser Asn Ser Ser 
            580                 585                 590         


Ala Met His Leu Ser Asp Leu Lys Pro Arg His Lys Tyr Gln Cys Thr 
        595                 600                 605             


Val Arg Ser Ser Cys Gly Val Gly Gln Asn His Pro Ser Ala Ser Ala 
    610                 615                 620                 


Trp Thr Leu Ser Asp Gln Leu Pro Pro Pro Pro Ala Asn Ile Ser Ile 
625                 630                 635                 640 


Trp Asn Ile Ser Asp Thr Ser Ala Val Leu Thr Trp Ala Val Ala Glu 
                645                 650                 655     


Gly Glu Ser Val Ser Arg Ala Val Ile Arg Phe Gln Gln Val Glu Gln 
            660                 665                 670         


Ala Gln Tyr Arg Gln Gln Val Glu Leu Pro Val Gln Thr Gln Gln Leu 
        675                 680                 685             


His Met Arg Phe Gln Leu Leu Gly Leu Arg Pro Asn Thr Gly Tyr Gln 
    690                 695                 700                 


Leu Gln Leu Trp Thr Val Asn Asn Met Gly Glu Ser Ala Glu Ser Pro 
705                 710                 715                 720 


Pro Val Ser Leu Met Thr Leu Pro Gln Gln Glu Ser Ser Ala Leu Phe 
                725                 730                 735     


Ala Ala His Gly His Leu Leu Leu Tyr Ala Ile Leu Gly Ser Ala Gly 
            740                 745                 750         


Met Thr Cys Cys Thr Val Leu Leu Ala Phe Cys Ile Val Leu Gln Leu 
        755                 760                 765             


Lys Arg Asn Thr Leu Gln Arg Arg Ile His Ser Ile Leu Arg Glu Glu 
    770                 775                 780                 


Pro Ala Val His Phe Ser Ser Ala Pro Pro Pro His Arg Arg Ser Ala 
785                 790                 795                 800 


Val Val Ser Arg Ser Leu Val Phe Pro Ala Leu Gln Trp Ser Asp Ile 
                805                 810                 815     


Gln Phe Gln Asp Val Leu Gly Glu Gly Asn Phe Gly Gln Val Leu Lys 
            820                 825                 830         


Ala Arg Ile Arg Lys Asp Gly Leu Arg Met Asp Ala Ala Val Lys Arg 
        835                 840                 845             


Met Lys Asp Tyr Ala Ser Gln Asp Asp His Arg Asp Phe Ala Gly Glu 
    850                 855                 860                 


Leu Glu Val Leu Cys Arg Leu Gly Pro His Lys Asn Ile Ile His Leu 
865                 870                 875                 880 


Leu Gly Ala Cys Glu His Arg Gly Tyr Leu Tyr Leu Ala Ile Glu Phe 
                885                 890                 895     


Ala Pro His Gly Asn Leu Leu Asp Phe Leu Arg Lys Ser Arg Val Leu 
            900                 905                 910         


Glu Thr Asp Pro Ala Phe Ala Ile Ala His Arg Thr Ala Ser Thr Leu 
        915                 920                 925             


Ser Ser Gln Gln Leu Leu Ala Phe Ser Ala Asp Val Ala Arg Gly Met 
    930                 935                 940                 


Ser Tyr Leu Ser Gln Lys Gln Phe Ile His Arg Asp Leu Ala Ala Arg 
945                 950                 955                 960 


Asn Val Leu Val Gly Glu Asn Phe Val Ala Lys Ile Ala Asp Phe Gly 
                965                 970                 975     


Leu Ser Arg Gly Gln Glu Val Tyr Val Lys Lys Thr Met Gly Arg Leu 
            980                 985                 990         


Pro Val Arg Trp Met Ala Ile Glu  Ser Leu Asn Tyr Ser  Val Tyr Thr 
        995                 1000                 1005             


Thr Asn  Ser Asp Val Trp Ser  Tyr Gly Val Leu Leu  Trp Glu Val 
    1010                 1015                 1020             


Val Ser  Leu Gly Gly Thr Pro  Tyr Cys Gly Met Thr  Cys Ala Glu 
    1025                 1030                 1035             


Leu Tyr  Glu Lys Leu Pro Leu  Gly Phe Arg Leu Glu  Lys Pro Leu 
    1040                 1045                 1050             


Asn Cys  Asp Asp Glu Val Tyr  Glu Leu Met Gln Gln  Cys Trp Arg 
    1055                 1060                 1065             


Glu Lys  Pro Phe Glu Arg Pro  Ser Phe Ser Gln Ile  Leu Leu Ser 
    1070                 1075                 1080             


Leu Gly  Arg Met Leu Glu Glu  Arg Lys Thr Tyr Val  Asn Thr Thr 
    1085                 1090                 1095             


Leu Tyr  Glu Lys Phe Thr Tyr  Ala Gly Ile Asp Cys  Ser Ala Glu 
    1100                 1105                 1110             


Glu Ala  Gly 
    1115     


<210>  1166
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  1166

Met Ser Ala Arg Val Arg Ser Arg Ser Arg Gly Arg Gly Asp Gly Gln 
1               5                   10                  15      


Glu Ala Pro Asp Val Val Ala Phe Val Ala Pro Gly Glu Ser Gln Gln 
            20                  25                  30          


Glu Glu Pro Pro Thr Asp Asn Gln Asp Ile Glu Pro Gly Gln Glu Arg 
        35                  40                  45              


Glu Gly Thr Pro Pro Ile Glu Glu Arg Lys Val Glu Gly Asp Cys Gln 
    50                  55                  60                  


Glu Met Asp Leu Glu Lys Thr Arg Ser Glu Arg Gly Asp Gly Ser Asp 
65                  70                  75                  80  


Val Lys Glu Lys Thr Pro Pro Asn Pro Lys His Ala Lys Thr Lys Glu 
                85                  90                  95      


Ala Gly Asp Gly Gln Pro 
            100         


<210>  1167
<211>  1356
<212>  PRT
<213>  Homo sapiens

<400>  1167

Met Gln Ser Lys Val Leu Leu Ala Val Ala Leu Trp Leu Cys Val Glu 
1               5                   10                  15      


Thr Arg Ala Ala Ser Val Gly Leu Pro Ser Val Ser Leu Asp Leu Pro 
            20                  25                  30          


Arg Leu Ser Ile Gln Lys Asp Ile Leu Thr Ile Lys Ala Asn Thr Thr 
        35                  40                  45              


Leu Gln Ile Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro 
    50                  55                  60                  


Asn Asn Gln Ser Gly Ser Glu Gln Arg Val Glu Val Thr Glu Cys Ser 
65                  70                  75                  80  


Asp Gly Leu Phe Cys Lys Thr Leu Thr Ile Pro Lys Val Ile Gly Asn 
                85                  90                  95      


Asp Thr Gly Ala Tyr Lys Cys Phe Tyr Arg Glu Thr Asp Leu Ala Ser 
            100                 105                 110         


Val Ile Tyr Val Tyr Val Gln Asp Tyr Arg Ser Pro Phe Ile Ala Ser 
        115                 120                 125             


Val Ser Asp Gln His Gly Val Val Tyr Ile Thr Glu Asn Lys Asn Lys 
    130                 135                 140                 


Thr Val Val Ile Pro Cys Leu Gly Ser Ile Ser Asn Leu Asn Val Ser 
145                 150                 155                 160 


Leu Cys Ala Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg 
                165                 170                 175     


Ile Ser Trp Asp Ser Lys Lys Gly Phe Thr Ile Pro Ser Tyr Met Ile 
            180                 185                 190         


Ser Tyr Ala Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Ser 
        195                 200                 205             


Tyr Gln Ser Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile Tyr 
    210                 215                 220                 


Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu 
225                 230                 235                 240 


Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile 
                245                 250                 255     


Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu 
            260                 265                 270         


Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe 
        275                 280                 285             


Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu 
    290                 295                 300                 


Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr 
305                 310                 315                 320 


Phe Val Arg Val His Glu Lys Pro Phe Val Ala Phe Gly Ser Gly Met 
                325                 330                 335     


Glu Ser Leu Val Glu Ala Thr Val Gly Glu Arg Val Arg Ile Pro Ala 
            340                 345                 350         


Lys Tyr Leu Gly Tyr Pro Pro Pro Glu Ile Lys Trp Tyr Lys Asn Gly 
        355                 360                 365             


Ile Pro Leu Glu Ser Asn His Thr Ile Lys Ala Gly His Val Leu Thr 
    370                 375                 380                 


Ile Met Glu Val Ser Glu Arg Asp Thr Gly Asn Tyr Thr Val Ile Leu 
385                 390                 395                 400 


Thr Asn Pro Ile Ser Lys Glu Lys Gln Ser His Val Val Ser Leu Val 
                405                 410                 415     


Val Tyr Val Pro Pro Gln Ile Gly Glu Lys Ser Leu Ile Ser Pro Val 
            420                 425                 430         


Asp Ser Tyr Gln Tyr Gly Thr Thr Gln Thr Leu Thr Cys Thr Val Tyr 
        435                 440                 445             


Ala Ile Pro Pro Pro His His Ile His Trp Tyr Trp Gln Leu Glu Glu 
    450                 455                 460                 


Glu Cys Ala Asn Glu Pro Ser Gln Ala Val Ser Val Thr Asn Pro Tyr 
465                 470                 475                 480 


Pro Cys Glu Glu Trp Arg Ser Val Glu Asp Phe Gln Gly Gly Asn Lys 
                485                 490                 495     


Ile Glu Val Asn Lys Asn Gln Phe Ala Leu Ile Glu Gly Lys Asn Lys 
            500                 505                 510         


Thr Val Ser Thr Leu Val Ile Gln Ala Ala Asn Val Ser Ala Leu Tyr 
        515                 520                 525             


Lys Cys Glu Ala Val Asn Lys Val Gly Arg Gly Glu Arg Val Ile Ser 
    530                 535                 540                 


Phe His Val Thr Arg Gly Pro Glu Ile Thr Leu Gln Pro Asp Met Gln 
545                 550                 555                 560 


Pro Thr Glu Gln Glu Ser Val Ser Leu Trp Cys Thr Ala Asp Arg Ser 
                565                 570                 575     


Thr Phe Glu Asn Leu Thr Trp Tyr Lys Leu Gly Pro Gln Pro Leu Pro 
            580                 585                 590         


Ile His Val Gly Glu Leu Pro Thr Pro Val Cys Lys Asn Leu Asp Thr 
        595                 600                 605             


Leu Trp Lys Leu Asn Ala Thr Met Phe Ser Asn Ser Thr Asn Asp Ile 
    610                 615                 620                 


Leu Ile Met Glu Leu Lys Asn Ala Ser Leu Gln Asp Gln Gly Asp Tyr 
625                 630                 635                 640 


Val Cys Leu Ala Gln Asp Arg Lys Thr Lys Lys Arg His Cys Val Val 
                645                 650                 655     


Arg Gln Leu Thr Val Leu Glu Arg Val Ala Pro Thr Ile Thr Gly Asn 
            660                 665                 670         


Leu Glu Asn Gln Thr Thr Ser Ile Gly Glu Ser Ile Glu Val Ser Cys 
        675                 680                 685             


Thr Ala Ser Gly Asn Pro Pro Pro Gln Ile Met Trp Phe Lys Asp Asn 
    690                 695                 700                 


Glu Thr Leu Val Glu Asp Ser Gly Ile Val Leu Lys Asp Gly Asn Arg 
705                 710                 715                 720 


Asn Leu Thr Ile Arg Arg Val Arg Lys Glu Asp Glu Gly Leu Tyr Thr 
                725                 730                 735     


Cys Gln Ala Cys Ser Val Leu Gly Cys Ala Lys Val Glu Ala Phe Phe 
            740                 745                 750         


Ile Ile Glu Gly Ala Gln Glu Lys Thr Asn Leu Glu Ile Ile Ile Leu 
        755                 760                 765             


Val Gly Thr Ala Val Ile Ala Met Phe Phe Trp Leu Leu Leu Val Ile 
    770                 775                 780                 


Ile Leu Arg Thr Val Lys Arg Ala Asn Gly Gly Glu Leu Lys Thr Gly 
785                 790                 795                 800 


Tyr Leu Ser Ile Val Met Asp Pro Asp Glu Leu Pro Leu Asp Glu His 
                805                 810                 815     


Cys Glu Arg Leu Pro Tyr Asp Ala Ser Lys Trp Glu Phe Pro Arg Asp 
            820                 825                 830         


Arg Leu Lys Leu Gly Lys Pro Leu Gly Arg Gly Ala Phe Gly Gln Val 
        835                 840                 845             


Ile Glu Ala Asp Ala Phe Gly Ile Asp Lys Thr Ala Thr Cys Arg Thr 
    850                 855                 860                 


Val Ala Val Lys Met Leu Lys Glu Gly Ala Thr His Ser Glu His Arg 
865                 870                 875                 880 


Ala Leu Met Ser Glu Leu Lys Ile Leu Ile His Ile Gly His His Leu 
                885                 890                 895     


Asn Val Val Asn Leu Leu Gly Ala Cys Thr Lys Pro Gly Gly Pro Leu 
            900                 905                 910         


Met Val Ile Val Glu Phe Cys Lys Phe Gly Asn Leu Ser Thr Tyr Leu 
        915                 920                 925             


Arg Ser Lys Arg Asn Glu Phe Val Pro Tyr Lys Thr Lys Gly Ala Arg 
    930                 935                 940                 


Phe Arg Gln Gly Lys Asp Tyr Val Gly Ala Ile Pro Val Asp Leu Lys 
945                 950                 955                 960 


Arg Arg Leu Asp Ser Ile Thr Ser Ser Gln Ser Ser Ala Ser Ser Gly 
                965                 970                 975     


Phe Val Glu Glu Lys Ser Leu Ser Asp Val Glu Glu Glu Glu Ala Pro 
            980                 985                 990         


Glu Asp Leu Tyr Lys Asp Phe Leu  Thr Leu Glu His Leu  Ile Cys Tyr 
        995                 1000                 1005             


Ser Phe  Gln Val Ala Lys Gly  Met Glu Phe Leu Ala  Ser Arg Lys 
    1010                 1015                 1020             


Cys Ile  His Arg Asp Leu Ala  Ala Arg Asn Ile Leu  Leu Ser Glu 
    1025                 1030                 1035             


Lys Asn  Val Val Lys Ile Cys  Asp Phe Gly Leu Ala  Arg Asp Ile 
    1040                 1045                 1050             


Tyr Lys  Asp Pro Asp Tyr Val  Arg Lys Gly Asp Ala  Arg Leu Pro 
    1055                 1060                 1065             


Leu Lys  Trp Met Ala Pro Glu  Thr Ile Phe Asp Arg  Val Tyr Thr 
    1070                 1075                 1080             


Ile Gln  Ser Asp Val Trp Ser  Phe Gly Val Leu Leu  Trp Glu Ile 
    1085                 1090                 1095             


Phe Ser  Leu Gly Ala Ser Pro  Tyr Pro Gly Val Lys  Ile Asp Glu 
    1100                 1105                 1110             


Glu Phe  Cys Arg Arg Leu Lys  Glu Gly Thr Arg Met  Arg Ala Pro 
    1115                 1120                 1125             


Asp Tyr  Thr Thr Pro Glu Met  Tyr Gln Thr Met Leu  Asp Cys Trp 
    1130                 1135                 1140             


His Gly  Glu Pro Ser Gln Arg  Pro Thr Phe Ser Glu  Leu Val Glu 
    1145                 1150                 1155             


His Leu  Gly Asn Leu Leu Gln  Ala Asn Ala Gln Gln  Asp Gly Lys 
    1160                 1165                 1170             


Asp Tyr  Ile Val Leu Pro Ile  Ser Glu Thr Leu Ser  Met Glu Glu 
    1175                 1180                 1185             


Asp Ser  Gly Leu Ser Leu Pro  Thr Ser Pro Val Ser  Cys Met Glu 
    1190                 1195                 1200             


Glu Glu  Glu Val Cys Asp Pro  Lys Phe His Tyr Asp  Asn Thr Ala 
    1205                 1210                 1215             


Gly Ile  Ser Gln Tyr Leu Gln  Asn Ser Lys Arg Lys  Ser Arg Pro 
    1220                 1225                 1230             


Val Ser  Val Lys Thr Phe Glu  Asp Ile Pro Leu Glu  Glu Pro Glu 
    1235                 1240                 1245             


Val Lys  Val Ile Pro Asp Asp  Asn Gln Thr Asp Ser  Gly Met Val 
    1250                 1255                 1260             


Leu Ala  Ser Glu Glu Leu Lys  Thr Leu Glu Asp Arg  Thr Lys Leu 
    1265                 1270                 1275             


Ser Pro  Ser Phe Gly Gly Met  Val Pro Ser Lys Ser  Arg Glu Ser 
    1280                 1285                 1290             


Val Ala  Ser Glu Gly Ser Asn  Gln Thr Ser Gly Tyr  Gln Ser Gly 
    1295                 1300                 1305             


Tyr His  Ser Asp Asp Thr Asp  Thr Thr Val Tyr Ser  Ser Glu Glu 
    1310                 1315                 1320             


Ala Glu  Leu Leu Lys Leu Ile  Glu Ile Gly Val Gln  Thr Gly Ser 
    1325                 1330                 1335             


Thr Ala  Gln Ile Leu Gln Pro  Asp Ser Gly Thr Thr  Leu Ser Ser 
    1340                 1345                 1350             


Pro Pro  Val 
    1355     


<210>  1168
<211>  1106
<212>  PRT
<213>  Homo sapiens

<400>  1168

Met Arg Leu Pro Gly Ala Met Pro Ala Leu Ala Leu Lys Gly Glu Leu 
1               5                   10                  15      


Leu Leu Leu Ser Leu Leu Leu Leu Leu Glu Pro Gln Ile Ser Gln Gly 
            20                  25                  30          


Leu Val Val Thr Pro Pro Gly Pro Glu Leu Val Leu Asn Val Ser Ser 
        35                  40                  45              


Thr Phe Val Leu Thr Cys Ser Gly Ser Ala Pro Val Val Trp Glu Arg 
    50                  55                  60                  


Met Ser Gln Glu Pro Pro Gln Glu Met Ala Lys Ala Gln Asp Gly Thr 
65                  70                  75                  80  


Phe Ser Ser Val Leu Thr Leu Thr Asn Leu Thr Gly Leu Asp Thr Gly 
                85                  90                  95      


Glu Tyr Phe Cys Thr His Asn Asp Ser Arg Gly Leu Glu Thr Asp Glu 
            100                 105                 110         


Arg Lys Arg Leu Tyr Ile Phe Val Pro Asp Pro Thr Val Gly Phe Leu 
        115                 120                 125             


Pro Asn Asp Ala Glu Glu Leu Phe Ile Phe Leu Thr Glu Ile Thr Glu 
    130                 135                 140                 


Ile Thr Ile Pro Cys Arg Val Thr Asp Pro Gln Leu Val Val Thr Leu 
145                 150                 155                 160 


His Glu Lys Lys Gly Asp Val Ala Leu Pro Val Pro Tyr Asp His Gln 
                165                 170                 175     


Arg Gly Phe Ser Gly Ile Phe Glu Asp Arg Ser Tyr Ile Cys Lys Thr 
            180                 185                 190         


Thr Ile Gly Asp Arg Glu Val Asp Ser Asp Ala Tyr Tyr Val Tyr Arg 
        195                 200                 205             


Leu Gln Val Ser Ser Ile Asn Val Ser Val Asn Ala Val Gln Thr Val 
    210                 215                 220                 


Val Arg Gln Gly Glu Asn Ile Thr Leu Met Cys Ile Val Ile Gly Asn 
225                 230                 235                 240 


Glu Val Val Asn Phe Glu Trp Thr Tyr Pro Arg Lys Glu Ser Gly Arg 
                245                 250                 255     


Leu Val Glu Pro Val Thr Asp Phe Leu Leu Asp Met Pro Tyr His Ile 
            260                 265                 270         


Arg Ser Ile Leu His Ile Pro Ser Ala Glu Leu Glu Asp Ser Gly Thr 
        275                 280                 285             


Tyr Thr Cys Asn Val Thr Glu Ser Val Asn Asp His Gln Asp Glu Lys 
    290                 295                 300                 


Ala Ile Asn Ile Thr Val Val Glu Ser Gly Tyr Val Arg Leu Leu Gly 
305                 310                 315                 320 


Glu Val Gly Thr Leu Gln Phe Ala Glu Leu His Arg Ser Arg Thr Leu 
                325                 330                 335     


Gln Val Val Phe Glu Ala Tyr Pro Pro Pro Thr Val Leu Trp Phe Lys 
            340                 345                 350         


Asp Asn Arg Thr Leu Gly Asp Ser Ser Ala Gly Glu Ile Ala Leu Ser 
        355                 360                 365             


Thr Arg Asn Val Ser Glu Thr Arg Tyr Val Ser Glu Leu Thr Leu Val 
    370                 375                 380                 


Arg Val Lys Val Ala Glu Ala Gly His Tyr Thr Met Arg Ala Phe His 
385                 390                 395                 400 


Glu Asp Ala Glu Val Gln Leu Ser Phe Gln Leu Gln Ile Asn Val Pro 
                405                 410                 415     


Val Arg Val Leu Glu Leu Ser Glu Ser His Pro Asp Ser Gly Glu Gln 
            420                 425                 430         


Thr Val Arg Cys Arg Gly Arg Gly Met Pro Gln Pro Asn Ile Ile Trp 
        435                 440                 445             


Ser Ala Cys Arg Asp Leu Lys Arg Cys Pro Arg Glu Leu Pro Pro Thr 
    450                 455                 460                 


Leu Leu Gly Asn Ser Ser Glu Glu Glu Ser Gln Leu Glu Thr Asn Val 
465                 470                 475                 480 


Thr Tyr Trp Glu Glu Glu Gln Glu Phe Glu Val Val Ser Thr Leu Arg 
                485                 490                 495     


Leu Gln His Val Asp Arg Pro Leu Ser Val Arg Cys Thr Leu Arg Asn 
            500                 505                 510         


Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser Leu 
        515                 520                 525             


Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu 
    530                 535                 540                 


Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys Pro 
545                 550                 555                 560 


Arg Tyr Glu Ile Arg Trp Lys Val Ile Glu Ser Val Ser Ser Asp Gly 
                565                 570                 575     


His Glu Tyr Ile Tyr Val Asp Pro Met Gln Leu Pro Tyr Asp Ser Thr 
            580                 585                 590         


Trp Glu Leu Pro Arg Asp Gln Leu Val Leu Gly Arg Thr Leu Gly Ser 
        595                 600                 605             


Gly Ala Phe Gly Gln Val Val Glu Ala Thr Ala His Gly Leu Ser His 
    610                 615                 620                 


Ser Gln Ala Thr Met Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala 
625                 630                 635                 640 


Arg Ser Ser Glu Lys Gln Ala Leu Met Ser Glu Leu Lys Ile Met Ser 
                645                 650                 655     


His Leu Gly Pro His Leu Asn Val Val Asn Leu Leu Gly Ala Cys Thr 
            660                 665                 670         


Lys Gly Gly Pro Ile Tyr Ile Ile Thr Glu Tyr Cys Arg Tyr Gly Asp 
        675                 680                 685             


Leu Val Asp Tyr Leu His Arg Asn Lys His Thr Phe Leu Gln His His 
    690                 695                 700                 


Ser Asp Lys Arg Arg Pro Pro Ser Ala Glu Leu Tyr Ser Asn Ala Leu 
705                 710                 715                 720 


Pro Val Gly Leu Pro Leu Pro Ser His Val Ser Leu Thr Gly Glu Ser 
                725                 730                 735     


Asp Gly Gly Tyr Met Asp Met Ser Lys Asp Glu Ser Val Asp Tyr Val 
            740                 745                 750         


Pro Met Leu Asp Met Lys Gly Asp Val Lys Tyr Ala Asp Ile Glu Ser 
        755                 760                 765             


Ser Asn Tyr Met Ala Pro Tyr Asp Asn Tyr Val Pro Ser Ala Pro Glu 
    770                 775                 780                 


Arg Thr Cys Arg Ala Thr Leu Ile Asn Glu Ser Pro Val Leu Ser Tyr 
785                 790                 795                 800 


Met Asp Leu Val Gly Phe Ser Tyr Gln Val Ala Asn Gly Met Glu Phe 
                805                 810                 815     


Leu Ala Ser Lys Asn Cys Val His Arg Asp Leu Ala Ala Arg Asn Val 
            820                 825                 830         


Leu Ile Cys Glu Gly Lys Leu Val Lys Ile Cys Asp Phe Gly Leu Ala 
        835                 840                 845             


Arg Asp Ile Met Arg Asp Ser Asn Tyr Ile Ser Lys Gly Ser Thr Phe 
    850                 855                 860                 


Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Ser Leu Tyr 
865                 870                 875                 880 


Thr Thr Leu Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile 
                885                 890                 895     


Phe Thr Leu Gly Gly Thr Pro Tyr Pro Glu Leu Pro Met Asn Glu Gln 
            900                 905                 910         


Phe Tyr Asn Ala Ile Lys Arg Gly Tyr Arg Met Ala Gln Pro Ala His 
        915                 920                 925             


Ala Ser Asp Glu Ile Tyr Glu Ile Met Gln Lys Cys Trp Glu Glu Lys 
    930                 935                 940                 


Phe Glu Ile Arg Pro Pro Phe Ser Gln Leu Val Leu Leu Leu Glu Arg 
945                 950                 955                 960 


Leu Leu Gly Glu Gly Tyr Lys Lys Lys Tyr Gln Gln Val Asp Glu Glu 
                965                 970                 975     


Phe Leu Arg Ser Asp His Pro Ala Ile Leu Arg Ser Gln Ala Arg Leu 
            980                 985                 990         


Pro Gly Phe His Gly Leu Arg Ser  Pro Leu Asp Thr Ser  Ser Val Leu 
        995                 1000                 1005             


Tyr Thr  Ala Val Gln Pro Asn  Glu Gly Asp Asn Asp  Tyr Ile Ile 
    1010                 1015                 1020             


Pro Leu  Pro Asp Pro Lys Pro  Glu Val Ala Asp Glu  Gly Pro Leu 
    1025                 1030                 1035             


Glu Gly  Ser Pro Ser Leu Ala  Ser Ser Thr Leu Asn  Glu Val Asn 
    1040                 1045                 1050             


Thr Ser  Ser Thr Ile Ser Cys  Asp Ser Pro Leu Glu  Pro Gln Asp 
    1055                 1060                 1065             


Glu Pro  Glu Pro Glu Pro Gln  Leu Glu Leu Gln Val  Glu Pro Glu 
    1070                 1075                 1080             


Pro Glu  Leu Glu Gln Leu Pro  Asp Ser Gly Cys Pro  Ala Pro Arg 
    1085                 1090                 1095             


Ala Glu  Ala Glu Asp Ser Phe  Leu 
    1100                 1105     


<210>  1169
<211>  158
<212>  PRT
<213>  Human papillomavirus type 16

<400>  1169

Met His Gln Lys Arg Thr Ala Met Phe Gln Asp Pro Gln Glu Arg Pro 
1               5                   10                  15      


Arg Lys Leu Pro Gln Leu Cys Thr Glu Leu Gln Thr Thr Ile His Asp 
            20                  25                  30          


Ile Ile Leu Glu Cys Val Tyr Cys Lys Gln Gln Leu Leu Arg Arg Glu 
        35                  40                  45              


Val Tyr Asp Phe Ala Phe Arg Asp Leu Cys Ile Val Tyr Arg Asp Gly 
    50                  55                  60                  


Asn Pro Tyr Ala Val Cys Asp Lys Cys Leu Lys Phe Tyr Ser Lys Ile 
65                  70                  75                  80  


Ser Glu Tyr Arg His Tyr Cys Tyr Ser Leu Tyr Gly Thr Thr Leu Glu 
                85                  90                  95      


Gln Gln Tyr Asn Lys Pro Leu Cys Asp Leu Leu Ile Arg Cys Ile Asn 
            100                 105                 110         


Cys Gln Lys Pro Leu Cys Pro Glu Glu Lys Gln Arg His Leu Asp Lys 
        115                 120                 125             


Lys Gln Arg Phe His Asn Ile Arg Gly Arg Trp Thr Gly Arg Cys Met 
    130                 135                 140                 


Ser Cys Cys Arg Ser Ser Arg Thr Arg Arg Glu Thr Gln Leu 
145                 150                 155             


<210>  1170
<211>  158
<212>  PRT
<213>  Human papillomavirus type 18

<400>  1170

Met Ala Arg Phe Glu Asp Pro Thr Arg Arg Pro Tyr Lys Leu Pro Asp 
1               5                   10                  15      


Leu Cys Thr Glu Leu Asn Thr Ser Leu Gln Asp Ile Glu Ile Thr Cys 
            20                  25                  30          


Val Tyr Cys Lys Thr Val Leu Glu Leu Thr Glu Val Phe Glu Phe Ala 
        35                  40                  45              


Phe Lys Asp Leu Phe Val Val Tyr Arg Asp Ser Ile Pro His Ala Ala 
    50                  55                  60                  


Cys His Lys Cys Ile Asp Phe Tyr Ser Arg Ile Arg Glu Leu Arg His 
65                  70                  75                  80  


Tyr Ser Asp Ser Val Tyr Gly Asp Thr Leu Glu Lys Leu Thr Asn Thr 
                85                  90                  95      


Gly Leu Tyr Asn Leu Leu Ile Arg Cys Leu Arg Cys Gln Lys Pro Leu 
            100                 105                 110         


Asn Pro Ala Glu Lys Leu Arg His Leu Asn Glu Lys Arg Arg Phe His 
        115                 120                 125             


Asn Ile Ala Gly His Tyr Arg Gly Gln Cys His Ser Cys Cys Asn Arg 
    130                 135                 140                 


Ala Arg Gln Glu Arg Leu Gln Arg Arg Arg Glu Thr Gln Val 
145                 150                 155             


<210>  1171
<211>  150
<212>  PRT
<213>  Human papillomavirus type 11

<400>  1171

Met Glu Ser Lys Asp Ala Ser Thr Ser Ala Thr Ser Ile Asp Gln Leu 
1               5                   10                  15      


Cys Lys Thr Phe Asn Leu Ser Leu His Thr Leu Gln Ile Gln Cys Val 
            20                  25                  30          


Phe Cys Arg Asn Ala Leu Thr Thr Ala Glu Ile Tyr Ala Tyr Ala Tyr 
        35                  40                  45              


Lys Asn Leu Lys Val Val Trp Arg Asp Asn Phe Pro Phe Ala Ala Cys 
    50                  55                  60                  


Ala Cys Cys Leu Glu Leu Gln Gly Lys Ile Asn Gln Tyr Arg His Phe 
65                  70                  75                  80  


Asn Tyr Ala Ala Tyr Ala Pro Thr Val Glu Glu Glu Thr Asn Glu Asp 
                85                  90                  95      


Ile Leu Lys Val Leu Ile Arg Cys Tyr Leu Cys His Lys Pro Leu Cys 
            100                 105                 110         


Glu Ile Glu Lys Leu Lys His Ile Leu Gly Lys Ala Arg Phe Ile Lys 
        115                 120                 125             


Leu Asn Asn Gln Trp Lys Gly Arg Cys Leu His Cys Trp Thr Thr Cys 
    130                 135                 140                 


Met Glu Asp Leu Leu Pro 
145                 150 


<210>  1172
<211>  150
<212>  PRT
<213>  Human papillomavirus type 6

<400>  1172

Met Glu Ser Ala Asn Ala Ser Thr Ser Ala Thr Thr Ile Asp Gln Leu 
1               5                   10                  15      


Cys Lys Thr Phe Asn Leu Ser Met His Thr Leu Gln Ile Asn Cys Val 
            20                  25                  30          


Phe Cys Lys Asn Ala Leu Thr Thr Ala Glu Ile Tyr Ser Tyr Ala Tyr 
        35                  40                  45              


Lys Gln Leu Lys Val Leu Phe Arg Gly Gly Tyr Pro Tyr Ala Ala Cys 
    50                  55                  60                  


Ala Cys Cys Leu Glu Phe His Gly Lys Ile Asn Gln Tyr Arg His Phe 
65                  70                  75                  80  


Asp Tyr Ala Gly Tyr Ala Thr Thr Val Glu Glu Glu Thr Lys Gln Asp 
                85                  90                  95      


Ile Leu Asp Val Leu Ile Arg Cys Tyr Leu Cys His Lys Pro Leu Cys 
            100                 105                 110         


Glu Val Glu Lys Val Lys His Ile Leu Thr Lys Ala Arg Phe Ile Lys 
        115                 120                 125             


Leu Asn Cys Thr Trp Lys Gly Arg Cys Leu His Cys Trp Thr Thr Cys 
    130                 135                 140                 


Met Glu Asp Met Leu Pro 
145                 150 


<210>  1173
<211>  98
<212>  PRT
<213>  Human papillomavirus type 6

<400>  1173

Met His Gly Arg His Val Thr Leu Lys Asp Ile Val Leu Asp Leu Gln 
1               5                   10                  15      


Pro Pro Asp Pro Val Gly Leu His Cys Tyr Glu Gln Leu Val Asp Ser 
            20                  25                  30          


Ser Glu Asp Glu Val Asp Glu Val Asp Gly Gln Asp Ser Gln Pro Leu 
        35                  40                  45              


Lys Gln His Phe Gln Ile Val Thr Cys Cys Cys Gly Cys Asp Ser Asn 
    50                  55                  60                  


Val Arg Leu Val Val Gln Cys Thr Glu Thr Asp Ile Arg Glu Val Gln 
65                  70                  75                  80  


Gln Leu Leu Leu Gly Thr Leu Asn Ile Val Cys Pro Ile Cys Ala Pro 
                85                  90                  95      


Lys Thr 
        


<210>  1174
<211>  98
<212>  PRT
<213>  Human papillomavirus type 11

<400>  1174

Met His Gly Arg Leu Val Thr Leu Lys Asp Ile Val Leu Asp Leu Gln 
1               5                   10                  15      


Pro Pro Asp Pro Val Gly Leu His Cys Tyr Glu Gln Leu Glu Asp Ser 
            20                  25                  30          


Ser Glu Asp Glu Val Asp Lys Val Asp Lys Gln Asp Ala Gln Pro Leu 
        35                  40                  45              


Thr Gln His Tyr Gln Ile Leu Thr Cys Cys Cys Gly Cys Asp Ser Asn 
    50                  55                  60                  


Val Arg Leu Val Val Glu Cys Thr Asp Gly Asp Ile Arg Gln Leu Gln 
65                  70                  75                  80  


Asp Leu Leu Leu Gly Thr Leu Asn Ile Val Cys Pro Ile Cys Ala Pro 
                85                  90                  95      


Lys Pro 
        


<210>  1175
<211>  98
<212>  PRT
<213>  Human papillomavirus type 16

<400>  1175

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln 
                85                  90                  95      


Lys Pro 
        


<210>  1176
<211>  105
<212>  PRT
<213>  Human papillomavirus type 18

<400>  1176

Met His Gly Pro Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu 
1               5                   10                  15      


Pro Gln Asn Glu Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu Ser 
            20                  25                  30          


Asp Ser Glu Glu Glu Asn Asp Glu Ile Asp Gly Val Asn His Gln His 
        35                  40                  45              


Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met 
    50                  55                  60                  


Cys Cys Lys Cys Glu Ala Arg Ile Lys Leu Val Val Glu Ser Ser Ala 
65                  70                  75                  80  


Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe 
                85                  90                  95      


Val Cys Pro Trp Cys Ala Ser Gln Gln 
            100                 105 


<210>  1177
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  1177

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Val Ile Met 
            180                 185             


<210>  1178
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  1178

Met Ala Asp Ile Ile Ala Arg Leu Arg Glu Asp Gly Ile Gln Lys Arg 
1               5                   10                  15      


Val Ile Gln Glu Gly Arg Gly Glu Leu Pro Asp Phe Gln Asp Gly Thr 
            20                  25                  30          


Lys Ala Thr Phe His Tyr Arg Thr Leu His Ser Asp Asp Glu Gly Thr 
        35                  40                  45              


Val Leu Asp Asp Ser Arg Ala Arg Gly Lys Pro Met Glu Leu Ile Ile 
    50                  55                  60                  


Gly Lys Lys Phe Lys Leu Pro Val Trp Glu Thr Ile Val Cys Thr Met 
65                  70                  75                  80  


Arg Glu Gly Glu Ile Ala Gln Phe Leu Cys Asp Ile Lys His Val Val 
                85                  90                  95      


Leu Tyr Pro Leu Val Ala Lys Ser Leu Arg Asn Ile Ala Val Gly Lys 
            100                 105                 110         


Asp Pro Leu Glu Gly Gln Arg His Cys Cys Gly Val Ala Gln Met Arg 
        115                 120                 125             


Glu His Ser Ser Leu Gly His Ala Asp Leu Asp Ala Leu Gln Gln Asn 
    130                 135                 140                 


Pro Gln Pro Leu Ile Phe His Met Glu Met Leu Lys Val Glu Ser Pro 
145                 150                 155                 160 


Gly Thr Tyr Gln Gln Asp Pro Trp Ala Met Thr Asp Glu Glu Lys Ala 
                165                 170                 175     


Lys Ala Val Pro Leu Ile His Gln Glu Gly Asn Arg Leu Tyr Arg Glu 
            180                 185                 190         


Gly His Val Lys Glu Ala Ala Ala Lys Tyr Tyr Asp Ala Ile Ala Cys 
        195                 200                 205             


Leu Lys Asn Leu Gln Met Lys Glu Gln Pro Gly Ser Pro Glu Trp Ile 
    210                 215                 220                 


Gln Leu Asp Gln Gln Ile Thr Pro Leu Leu Leu Asn Tyr Cys Gln Cys 
225                 230                 235                 240 


Lys Leu Val Val Glu Glu Tyr Tyr Glu Val Leu Asp His Cys Ser Ser 
                245                 250                 255     


Ile Leu Asn Lys Tyr Asp Asp Asn Val Lys Ala Tyr Phe Lys Arg Gly 
            260                 265                 270         


Lys Ala His Ala Ala Val Trp Asn Ala Gln Glu Ala Gln Ala Asp Phe 
        275                 280                 285             


Ala Lys Val Leu Glu Leu Asp Pro Ala Leu Ala Pro Val Val Ser Arg 
    290                 295                 300                 


Glu Leu Gln Ala Leu Glu Ala Arg Ile Arg Gln Lys Asp Glu Glu Asp 
305                 310                 315                 320 


Lys Ala Arg Phe Arg Gly Ile Phe Ser His 
                325                 330 


<210>  1179
<211>  1397
<212>  PRT
<213>  Homo sapiens

<400>  1179

Met Glu Glu Ile Ser Ala Ala Ala Val Lys Val Val Pro Gly Pro Glu 
1               5                   10                  15      


Arg Pro Ser Pro Phe Ser Gln Leu Val Tyr Thr Ser Asn Asp Ser Tyr 
            20                  25                  30          


Ile Val His Ser Gly Asp Leu Arg Lys Ile His Lys Ala Ala Ser Arg 
        35                  40                  45              


Gly Gln Val Arg Lys Leu Glu Lys Met Thr Lys Arg Lys Lys Thr Ile 
    50                  55                  60                  


Asn Leu Asn Ile Gln Asp Ala Gln Lys Arg Thr Ala Leu His Trp Ala 
65                  70                  75                  80  


Cys Val Asn Gly His Glu Glu Val Val Thr Phe Leu Val Asp Arg Lys 
                85                  90                  95      


Cys Gln Leu Asp Val Leu Asp Gly Glu His Arg Thr Pro Leu Met Lys 
            100                 105                 110         


Ala Leu Gln Cys His Gln Glu Ala Cys Ala Asn Ile Leu Ile Asp Ser 
        115                 120                 125             


Gly Ala Asp Ile Asn Leu Val Asp Val Tyr Gly Asn Thr Ala Leu His 
    130                 135                 140                 


Tyr Ala Val Tyr Ser Glu Ile Leu Ser Val Val Ala Lys Leu Leu Ser 
145                 150                 155                 160 


His Gly Ala Val Ile Glu Val His Asn Lys Ala Ser Leu Thr Pro Leu 
                165                 170                 175     


Leu Leu Ser Ile Thr Lys Arg Ser Glu Gln Ile Val Glu Phe Leu Leu 
            180                 185                 190         


Ile Lys Asn Ala Asn Ala Asn Ala Val Asn Lys Tyr Lys Cys Thr Ala 
        195                 200                 205             


Leu Met Leu Ala Val Cys His Gly Ser Ser Glu Ile Val Gly Met Leu 
    210                 215                 220                 


Leu Gln Gln Asn Val Asp Val Phe Ala Ala Asp Ile Cys Gly Val Thr 
225                 230                 235                 240 


Ala Glu His Tyr Ala Val Thr Cys Gly Phe His His Ile His Glu Gln 
                245                 250                 255     


Ile Met Glu Tyr Ile Arg Lys Leu Ser Lys Asn His Gln Asn Thr Asn 
            260                 265                 270         


Pro Glu Gly Thr Ser Ala Gly Thr Pro Asp Glu Ala Ala Pro Leu Ala 
        275                 280                 285             


Glu Arg Thr Pro Asp Thr Ala Glu Ser Leu Val Glu Lys Thr Pro Asp 
    290                 295                 300                 


Glu Ala Ala Pro Leu Val Glu Arg Thr Pro Asp Thr Ala Glu Ser Leu 
305                 310                 315                 320 


Val Glu Lys Thr Pro Asp Glu Ala Ala Ser Leu Val Glu Gly Thr Ser 
                325                 330                 335     


Asp Lys Ile Gln Cys Leu Glu Lys Ala Thr Ser Gly Lys Phe Glu Gln 
            340                 345                 350         


Ser Ala Glu Glu Thr Pro Arg Glu Ile Thr Ser Pro Ala Lys Glu Thr 
        355                 360                 365             


Ser Glu Lys Phe Thr Trp Pro Ala Lys Gly Arg Pro Arg Lys Ile Ala 
    370                 375                 380                 


Trp Glu Lys Lys Glu Asp Thr Pro Arg Glu Ile Met Ser Pro Ala Lys 
385                 390                 395                 400 


Glu Thr Ser Glu Lys Phe Thr Trp Ala Ala Lys Gly Arg Pro Arg Lys 
                405                 410                 415     


Ile Ala Trp Glu Lys Lys Glu Thr Pro Val Lys Thr Gly Cys Val Ala 
            420                 425                 430         


Arg Val Thr Ser Asn Lys Thr Lys Val Leu Glu Lys Gly Arg Ser Lys 
        435                 440                 445             


Met Ile Ala Cys Pro Thr Lys Glu Ser Ser Thr Lys Ala Ser Ala Asn 
    450                 455                 460                 


Asp Gln Arg Phe Pro Ser Glu Ser Lys Gln Glu Glu Asp Glu Glu Tyr 
465                 470                 475                 480 


Ser Cys Asp Ser Arg Ser Leu Phe Glu Ser Ser Ala Lys Ile Gln Val 
                485                 490                 495     


Cys Ile Pro Glu Ser Ile Tyr Gln Lys Val Met Glu Ile Asn Arg Glu 
            500                 505                 510         


Val Glu Glu Pro Pro Lys Lys Pro Ser Ala Phe Lys Pro Ala Ile Glu 
        515                 520                 525             


Met Gln Asn Ser Val Pro Asn Lys Ala Phe Glu Leu Lys Asn Glu Gln 
    530                 535                 540                 


Thr Leu Arg Ala Asp Pro Met Phe Pro Pro Glu Ser Lys Gln Lys Asp 
545                 550                 555                 560 


Tyr Glu Glu Asn Ser Trp Asp Ser Glu Ser Leu Cys Glu Thr Val Ser 
                565                 570                 575     


Gln Lys Asp Val Cys Leu Pro Lys Ala Thr His Gln Lys Glu Ile Asp 
            580                 585                 590         


Lys Ile Asn Gly Lys Leu Glu Glu Ser Pro Asn Lys Asp Gly Leu Leu 
        595                 600                 605             


Lys Ala Thr Cys Gly Met Lys Val Ser Ile Pro Thr Lys Ala Leu Glu 
    610                 615                 620                 


Leu Lys Asp Met Gln Thr Phe Lys Ala Glu Pro Pro Gly Lys Pro Ser 
625                 630                 635                 640 


Ala Phe Glu Pro Ala Thr Glu Met Gln Lys Ser Val Pro Asn Lys Ala 
                645                 650                 655     


Leu Glu Leu Lys Asn Glu Gln Thr Leu Arg Ala Asp Glu Ile Leu Pro 
            660                 665                 670         


Ser Glu Ser Lys Gln Lys Asp Tyr Glu Glu Asn Ser Trp Asp Thr Glu 
        675                 680                 685             


Ser Leu Cys Glu Thr Val Ser Gln Lys Asp Val Cys Leu Pro Lys Ala 
    690                 695                 700                 


Ala His Gln Lys Glu Ile Asp Lys Ile Asn Gly Lys Leu Glu Gly Ser 
705                 710                 715                 720 


Pro Val Lys Asp Gly Leu Leu Lys Ala Asn Cys Gly Met Lys Val Ser 
                725                 730                 735     


Ile Pro Thr Lys Ala Leu Glu Leu Met Asp Met Gln Thr Phe Lys Ala 
            740                 745                 750         


Glu Pro Pro Glu Lys Pro Ser Ala Phe Glu Pro Ala Ile Glu Met Gln 
        755                 760                 765             


Lys Ser Val Pro Asn Lys Ala Leu Glu Leu Lys Asn Glu Gln Thr Leu 
    770                 775                 780                 


Arg Ala Asp Glu Ile Leu Pro Ser Glu Ser Lys Gln Lys Asp Tyr Glu 
785                 790                 795                 800 


Glu Ser Ser Trp Asp Ser Glu Ser Leu Cys Glu Thr Val Ser Gln Lys 
                805                 810                 815     


Asp Val Cys Leu Pro Lys Ala Thr His Gln Lys Glu Ile Asp Lys Ile 
            820                 825                 830         


Asn Gly Lys Leu Glu Glu Ser Pro Asp Asn Asp Gly Phe Leu Lys Ala 
        835                 840                 845             


Pro Cys Arg Met Lys Val Ser Ile Pro Thr Lys Ala Leu Glu Leu Met 
    850                 855                 860                 


Asp Met Gln Thr Phe Lys Ala Glu Pro Pro Glu Lys Pro Ser Ala Phe 
865                 870                 875                 880 


Glu Pro Ala Ile Glu Met Gln Lys Ser Val Pro Asn Lys Ala Leu Glu 
                885                 890                 895     


Leu Lys Asn Glu Gln Thr Leu Arg Ala Asp Gln Met Phe Pro Ser Glu 
            900                 905                 910         


Ser Lys Gln Lys Lys Val Glu Glu Asn Ser Trp Asp Ser Glu Ser Leu 
        915                 920                 925             


Arg Glu Thr Val Ser Gln Lys Asp Val Cys Val Pro Lys Ala Thr His 
    930                 935                 940                 


Gln Lys Glu Met Asp Lys Ile Ser Gly Lys Leu Glu Asp Ser Thr Ser 
945                 950                 955                 960 


Leu Ser Lys Ile Leu Asp Thr Val His Ser Cys Glu Arg Ala Arg Glu 
                965                 970                 975     


Leu Gln Lys Asp His Cys Glu Gln Arg Thr Gly Lys Met Glu Gln Met 
            980                 985                 990         


Lys Lys Lys Phe Cys Val Leu Lys  Lys Lys Leu Ser Glu  Ala Lys Glu 
        995                 1000                 1005             


Ile Lys  Ser Gln Leu Glu Asn  Gln Lys Val Lys Trp  Glu Gln Glu 
    1010                 1015                 1020             


Leu Cys  Ser Val Arg Leu Thr  Leu Asn Gln Glu Glu  Glu Lys Arg 
    1025                 1030                 1035             


Arg Asn  Ala Asp Ile Leu Asn  Glu Lys Ile Arg Glu  Glu Leu Gly 
    1040                 1045                 1050             


Arg Ile  Glu Glu Gln His Arg  Lys Glu Leu Glu Val  Lys Gln Gln 
    1055                 1060                 1065             


Leu Glu  Gln Ala Leu Arg Ile  Gln Asp Ile Glu Leu  Lys Ser Val 
    1070                 1075                 1080             


Glu Ser  Asn Leu Asn Gln Val  Ser His Thr His Glu  Asn Glu Asn 
    1085                 1090                 1095             


Tyr Leu  Leu His Glu Asn Cys  Met Leu Lys Lys Glu  Ile Ala Met 
    1100                 1105                 1110             


Leu Lys  Leu Glu Ile Ala Thr  Leu Lys His Gln Tyr  Gln Glu Lys 
    1115                 1120                 1125             


Glu Asn  Lys Tyr Phe Glu Asp  Ile Lys Ile Leu Lys  Glu Lys Asn 
    1130                 1135                 1140             


Ala Glu  Leu Gln Met Thr Leu  Lys Leu Lys Glu Glu  Ser Leu Thr 
    1145                 1150                 1155             


Lys Arg  Ala Ser Gln Tyr Ser  Gly Gln Leu Lys Val  Leu Ile Ala 
    1160                 1165                 1170             


Glu Asn  Thr Met Leu Thr Ser  Lys Leu Lys Glu Lys  Gln Asp Lys 
    1175                 1180                 1185             


Glu Ile  Leu Glu Ala Glu Ile  Glu Ser His His Pro  Arg Leu Ala 
    1190                 1195                 1200             


Ser Ala  Val Gln Asp His Asp  Gln Ile Val Thr Ser  Arg Lys Ser 
    1205                 1210                 1215             


Gln Glu  Pro Ala Phe His Ile  Ala Gly Asp Ala Cys  Leu Gln Arg 
    1220                 1225                 1230             


Lys Met  Asn Val Asp Val Ser  Ser Thr Ile Tyr Asn  Asn Glu Val 
    1235                 1240                 1245             


Leu His  Gln Pro Leu Ser Glu  Ala Gln Arg Lys Ser  Lys Ser Leu 
    1250                 1255                 1260             


Lys Ile  Asn Leu Asn Tyr Ala  Gly Asp Ala Leu Arg  Glu Asn Thr 
    1265                 1270                 1275             


Leu Val  Ser Glu His Ala Gln  Arg Asp Gln Arg Glu  Thr Gln Cys 
    1280                 1285                 1290             


Gln Met  Lys Glu Ala Glu His  Met Tyr Gln Asn Glu  Gln Asp Asn 
    1295                 1300                 1305             


Val Asn  Lys His Thr Glu Gln  Gln Glu Ser Leu Asp  Gln Lys Leu 
    1310                 1315                 1320             


Phe Gln  Leu Gln Ser Lys Asn  Met Trp Leu Gln Gln  Gln Leu Val 
    1325                 1330                 1335             


His Ala  His Lys Lys Ala Asp  Asn Lys Ser Lys Ile  Thr Ile Asp 
    1340                 1345                 1350             


Ile His  Phe Leu Glu Arg Lys  Met Gln His His Leu  Leu Lys Glu 
    1355                 1360                 1365             


Lys Asn  Glu Glu Ile Phe Asn  Tyr Asn Asn His Leu  Lys Asn Arg 
    1370                 1375                 1380             


Ile Tyr  Gln Tyr Glu Lys Glu  Lys Ala Glu Thr Glu  Asn Ser 
    1385                 1390                 1395         


<210>  1180
<211>  2322
<212>  PRT
<213>  Homo sapiens

<400>  1180

Met Gln Ser Gly Pro Arg Pro Pro Leu Pro Ala Pro Gly Leu Ala Leu 
1               5                   10                  15      


Ala Leu Thr Leu Thr Met Leu Ala Arg Leu Ala Ser Ala Ala Ser Phe 
            20                  25                  30          


Phe Gly Glu Asn His Leu Glu Val Pro Val Ala Thr Ala Leu Thr Asp 
        35                  40                  45              


Ile Asp Leu Gln Leu Gln Phe Ser Thr Ser Gln Pro Glu Ala Leu Leu 
    50                  55                  60                  


Leu Leu Ala Ala Gly Pro Ala Asp His Leu Leu Leu Gln Leu Tyr Ser 
65                  70                  75                  80  


Gly Arg Leu Gln Val Arg Leu Val Leu Gly Gln Glu Glu Leu Arg Leu 
                85                  90                  95      


Gln Thr Pro Ala Glu Thr Leu Leu Ser Asp Ser Ile Pro His Thr Val 
            100                 105                 110         


Val Leu Thr Val Val Glu Gly Trp Ala Thr Leu Ser Val Asp Gly Phe 
        115                 120                 125             


Leu Asn Ala Ser Ser Ala Val Pro Gly Ala Pro Leu Glu Val Pro Tyr 
    130                 135                 140                 


Gly Leu Phe Val Gly Gly Thr Gly Thr Leu Gly Leu Pro Tyr Leu Arg 
145                 150                 155                 160 


Gly Thr Ser Arg Pro Leu Arg Gly Cys Leu His Ala Ala Thr Leu Asn 
                165                 170                 175     


Gly Arg Ser Leu Leu Arg Pro Leu Thr Pro Asp Val His Glu Gly Cys 
            180                 185                 190         


Ala Glu Glu Phe Ser Ala Ser Asp Asp Val Ala Leu Gly Phe Ser Gly 
        195                 200                 205             


Pro His Ser Leu Ala Ala Phe Pro Ala Trp Gly Thr Gln Asp Glu Gly 
    210                 215                 220                 


Thr Leu Glu Phe Thr Leu Thr Thr Gln Ser Arg Gln Ala Pro Leu Ala 
225                 230                 235                 240 


Phe Gln Ala Gly Gly Arg Arg Gly Asp Phe Ile Tyr Val Asp Ile Phe 
                245                 250                 255     


Glu Gly His Leu Arg Ala Val Val Glu Lys Gly Gln Gly Thr Val Leu 
            260                 265                 270         


Leu His Asn Ser Val Pro Val Ala Asp Gly Gln Pro His Glu Val Ser 
        275                 280                 285             


Val His Ile Asn Ala His Arg Leu Glu Ile Ser Val Asp Gln Tyr Pro 
    290                 295                 300                 


Thr His Thr Ser Asn Arg Gly Val Leu Ser Tyr Leu Glu Pro Arg Gly 
305                 310                 315                 320 


Ser Leu Leu Leu Gly Gly Leu Asp Ala Glu Ala Ser Arg His Leu Gln 
                325                 330                 335     


Glu His Arg Leu Gly Leu Thr Pro Glu Ala Thr Asn Ala Ser Leu Leu 
            340                 345                 350         


Gly Cys Met Glu Asp Leu Ser Val Asn Gly Gln Arg Arg Gly Leu Arg 
        355                 360                 365             


Glu Ala Leu Leu Thr Arg Asn Met Ala Ala Gly Cys Arg Leu Glu Glu 
    370                 375                 380                 


Glu Glu Tyr Glu Asp Asp Ala Tyr Gly His Tyr Glu Ala Phe Ser Thr 
385                 390                 395                 400 


Leu Ala Pro Glu Ala Trp Pro Ala Met Glu Leu Pro Glu Pro Cys Val 
                405                 410                 415     


Pro Glu Pro Gly Leu Pro Pro Val Phe Ala Asn Phe Thr Gln Leu Leu 
            420                 425                 430         


Thr Ile Ser Pro Leu Val Val Ala Glu Gly Gly Thr Ala Trp Leu Glu 
        435                 440                 445             


Trp Arg His Val Gln Pro Thr Leu Asp Leu Met Glu Ala Glu Leu Arg 
    450                 455                 460                 


Lys Ser Gln Val Leu Phe Ser Val Thr Arg Gly Ala Arg His Gly Glu 
465                 470                 475                 480 


Leu Glu Leu Asp Ile Pro Gly Ala Gln Ala Arg Lys Met Phe Thr Leu 
                485                 490                 495     


Leu Asp Val Val Asn Arg Lys Ala Arg Phe Ile His Asp Gly Ser Glu 
            500                 505                 510         


Asp Thr Ser Asp Gln Leu Val Leu Glu Val Ser Val Thr Ala Arg Val 
        515                 520                 525             


Pro Met Pro Ser Cys Leu Arg Arg Gly Gln Thr Tyr Leu Leu Pro Ile 
    530                 535                 540                 


Gln Val Asn Pro Val Asn Asp Pro Pro His Ile Ile Phe Pro His Gly 
545                 550                 555                 560 


Ser Leu Met Val Ile Leu Glu His Thr Gln Lys Pro Leu Gly Pro Glu 
                565                 570                 575     


Val Phe Gln Ala Tyr Asp Pro Asp Ser Ala Cys Glu Gly Leu Thr Phe 
            580                 585                 590         


Gln Val Leu Gly Thr Ser Ser Gly Leu Pro Val Glu Arg Arg Asp Gln 
        595                 600                 605             


Pro Gly Glu Pro Ala Thr Glu Phe Ser Cys Arg Glu Leu Glu Ala Gly 
    610                 615                 620                 


Ser Leu Val Tyr Val His Arg Gly Gly Pro Ala Gln Asp Leu Thr Phe 
625                 630                 635                 640 


Arg Val Ser Asp Gly Leu Gln Ala Ser Pro Pro Ala Thr Leu Lys Val 
                645                 650                 655     


Val Ala Ile Arg Pro Ala Ile Gln Ile His Arg Ser Thr Gly Leu Arg 
            660                 665                 670         


Leu Ala Gln Gly Ser Ala Met Pro Ile Leu Pro Ala Asn Leu Ser Val 
        675                 680                 685             


Glu Thr Asn Ala Val Gly Gln Asp Val Ser Val Leu Phe Arg Val Thr 
    690                 695                 700                 


Gly Ala Leu Gln Phe Gly Glu Leu Gln Lys Gln Gly Ala Gly Gly Val 
705                 710                 715                 720 


Glu Gly Ala Glu Trp Trp Ala Thr Gln Ala Phe His Gln Arg Asp Val 
                725                 730                 735     


Glu Gln Gly Arg Val Arg Tyr Leu Ser Thr Asp Pro Gln His His Ala 
            740                 745                 750         


Tyr Asp Thr Val Glu Asn Leu Ala Leu Glu Val Gln Val Gly Gln Glu 
        755                 760                 765             


Ile Leu Ser Asn Leu Ser Phe Pro Val Thr Ile Gln Arg Ala Thr Val 
    770                 775                 780                 


Trp Met Leu Arg Leu Glu Pro Leu His Thr Gln Asn Thr Gln Gln Glu 
785                 790                 795                 800 


Thr Leu Thr Thr Ala His Leu Glu Ala Thr Leu Glu Glu Ala Gly Pro 
                805                 810                 815     


Ser Pro Pro Thr Phe His Tyr Glu Val Val Gln Ala Pro Arg Lys Gly 
            820                 825                 830         


Asn Leu Gln Leu Gln Gly Thr Arg Leu Ser Asp Gly Gln Gly Phe Thr 
        835                 840                 845             


Gln Asp Asp Ile Gln Ala Gly Arg Val Thr Tyr Gly Ala Thr Ala Arg 
    850                 855                 860                 


Ala Ser Glu Ala Val Glu Asp Thr Phe Arg Phe Arg Val Thr Ala Pro 
865                 870                 875                 880 


Pro Tyr Phe Ser Pro Leu Tyr Thr Phe Pro Ile His Ile Gly Gly Asp 
                885                 890                 895     


Pro Asp Ala Pro Val Leu Thr Asn Val Leu Leu Val Val Pro Glu Gly 
            900                 905                 910         


Gly Glu Gly Val Leu Ser Ala Asp His Leu Phe Val Lys Ser Leu Asn 
        915                 920                 925             


Ser Ala Ser Tyr Leu Tyr Glu Val Met Glu Arg Pro Arg His Gly Arg 
    930                 935                 940                 


Leu Ala Trp Arg Gly Thr Gln Asp Lys Thr Thr Met Val Thr Ser Phe 
945                 950                 955                 960 


Thr Asn Glu Asp Leu Leu Arg Gly Arg Leu Val Tyr Gln His Asp Asp 
                965                 970                 975     


Ser Glu Thr Thr Glu Asp Asp Ile Pro Phe Val Ala Thr Arg Gln Gly 
            980                 985                 990         


Glu Ser Ser Gly Asp Met Ala Trp  Glu Glu Val Arg Gly  Val Phe Arg 
        995                 1000                 1005             


Val Ala  Ile Gln Pro Val Asn  Asp His Ala Pro Val  Gln Thr Ile 
    1010                 1015                 1020             


Ser Arg  Ile Phe His Val Ala  Arg Gly Gly Arg Arg  Leu Leu Thr 
    1025                 1030                 1035             


Thr Asp  Asp Val Ala Phe Ser  Asp Ala Asp Ser Gly  Phe Ala Asp 
    1040                 1045                 1050             


Ala Gln  Leu Val Leu Thr Arg  Lys Asp Leu Leu Phe  Gly Ser Ile 
    1055                 1060                 1065             


Val Ala  Val Asp Glu Pro Thr  Arg Pro Ile Tyr Arg  Phe Thr Gln 
    1070                 1075                 1080             


Glu Asp  Leu Arg Lys Arg Arg  Val Leu Phe Val His  Ser Gly Ala 
    1085                 1090                 1095             


Asp Arg  Gly Trp Ile Gln Leu  Gln Val Ser Asp Gly  Gln His Gln 
    1100                 1105                 1110             


Ala Thr  Ala Leu Leu Glu Val  Gln Ala Ser Glu Pro  Tyr Leu Arg 
    1115                 1120                 1125             


Val Ala  Asn Gly Ser Ser Leu  Val Val Pro Gln Gly  Gly Gln Gly 
    1130                 1135                 1140             


Thr Ile  Asp Thr Ala Val Leu  His Leu Asp Thr Asn  Leu Asp Ile 
    1145                 1150                 1155             


Arg Ser  Gly Asp Glu Val His  Tyr His Val Thr Ala  Gly Pro Arg 
    1160                 1165                 1170             


Trp Gly  Gln Leu Val Arg Ala  Gly Gln Pro Ala Thr  Ala Phe Ser 
    1175                 1180                 1185             


Gln Gln  Asp Leu Leu Asp Gly  Ala Val Leu Tyr Ser  His Asn Gly 
    1190                 1195                 1200             


Ser Leu  Ser Pro Arg Asp Thr  Met Ala Phe Ser Val  Glu Ala Gly 
    1205                 1210                 1215             


Pro Val  His Thr Asp Ala Thr  Leu Gln Val Thr Ile  Ala Leu Glu 
    1220                 1225                 1230             


Gly Pro  Leu Ala Pro Leu Lys  Leu Val Arg His Lys  Lys Ile Tyr 
    1235                 1240                 1245             


Val Phe  Gln Gly Glu Ala Ala  Glu Ile Arg Arg Asp  Gln Leu Glu 
    1250                 1255                 1260             


Ala Ala  Gln Glu Ala Val Pro  Pro Ala Asp Ile Val  Phe Ser Val 
    1265                 1270                 1275             


Lys Ser  Pro Pro Ser Ala Gly  Tyr Leu Val Met Val  Ser Arg Gly 
    1280                 1285                 1290             


Ala Leu  Ala Asp Glu Pro Pro  Ser Leu Asp Pro Val  Gln Ser Phe 
    1295                 1300                 1305             


Ser Gln  Glu Ala Val Asp Thr  Gly Arg Val Leu Tyr  Leu His Ser 
    1310                 1315                 1320             


Arg Pro  Glu Ala Trp Ser Asp  Ala Phe Ser Leu Asp  Val Ala Ser 
    1325                 1330                 1335             


Gly Leu  Gly Ala Pro Leu Glu  Gly Val Leu Val Glu  Leu Glu Val 
    1340                 1345                 1350             


Leu Pro  Ala Ala Ile Pro Leu  Glu Ala Gln Asn Phe  Ser Val Pro 
    1355                 1360                 1365             


Glu Gly  Gly Ser Leu Thr Leu  Ala Pro Pro Leu Leu  Arg Val Ser 
    1370                 1375                 1380             


Gly Pro  Tyr Phe Pro Thr Leu  Leu Gly Leu Ser Leu  Gln Val Leu 
    1385                 1390                 1395             


Glu Pro  Pro Gln His Gly Ala  Leu Gln Lys Glu Asp  Gly Pro Gln 
    1400                 1405                 1410             


Ala Arg  Thr Leu Ser Ala Phe  Ser Trp Arg Met Val  Glu Glu Gln 
    1415                 1420                 1425             


Leu Ile  Arg Tyr Val His Asp  Gly Ser Glu Thr Leu  Thr Asp Ser 
    1430                 1435                 1440             


Phe Val  Leu Met Ala Asn Ala  Ser Glu Met Asp Arg  Gln Ser His 
    1445                 1450                 1455             


Pro Val  Ala Phe Thr Val Thr  Val Leu Pro Val Asn  Asp Gln Pro 
    1460                 1465                 1470             


Pro Ile  Leu Thr Thr Asn Thr  Gly Leu Gln Met Trp  Glu Gly Ala 
    1475                 1480                 1485             


Thr Ala  Pro Ile Pro Ala Glu  Ala Leu Arg Ser Thr  Asp Gly Asp 
    1490                 1495                 1500             


Ser Gly  Ser Glu Asp Leu Val  Tyr Thr Ile Glu Gln  Pro Ser Asn 
    1505                 1510                 1515             


Gly Arg  Val Val Leu Arg Gly  Ala Pro Gly Thr Glu  Val Arg Ser 
    1520                 1525                 1530             


Phe Thr  Gln Ala Gln Leu Asp  Gly Gly Leu Val Leu  Phe Ser His 
    1535                 1540                 1545             


Arg Gly  Thr Leu Asp Gly Gly  Phe Arg Phe Arg Leu  Ser Asp Gly 
    1550                 1555                 1560             


Glu His  Thr Ser Pro Gly His  Phe Phe Arg Val Thr  Ala Gln Lys 
    1565                 1570                 1575             


Gln Val  Leu Leu Ser Leu Lys  Gly Ser Gln Thr Leu  Thr Val Cys 
    1580                 1585                 1590             


Pro Gly  Ser Val Gln Pro Leu  Ser Ser Gln Thr Leu  Arg Ala Ser 
    1595                 1600                 1605             


Ser Ser  Ala Gly Thr Asp Pro  Gln Leu Leu Leu Tyr  Arg Val Val 
    1610                 1615                 1620             


Arg Gly  Pro Gln Leu Gly Arg  Leu Phe His Ala Gln  Gln Asp Ser 
    1625                 1630                 1635             


Thr Gly  Glu Ala Leu Val Asn  Phe Thr Gln Ala Glu  Val Tyr Ala 
    1640                 1645                 1650             


Gly Asn  Ile Leu Tyr Glu His  Glu Met Pro Pro Glu  Pro Phe Trp 
    1655                 1660                 1665             


Glu Ala  His Asp Thr Leu Glu  Leu Gln Leu Ser Ser  Pro Pro Ala 
    1670                 1675                 1680             


Arg Asp  Val Ala Ala Thr Leu  Ala Val Ala Val Ser  Phe Glu Ala 
    1685                 1690                 1695             


Ala Cys  Pro Gln Arg Pro Ser  His Leu Trp Lys Asn  Lys Gly Leu 
    1700                 1705                 1710             


Trp Val  Pro Glu Gly Gln Arg  Ala Arg Ile Thr Val  Ala Ala Leu 
    1715                 1720                 1725             


Asp Ala  Ser Asn Leu Leu Ala  Ser Val Pro Ser Pro  Gln Arg Ser 
    1730                 1735                 1740             


Glu His  Asp Val Leu Phe Gln  Val Thr Gln Phe Pro  Ser Arg Gly 
    1745                 1750                 1755             


Gln Leu  Leu Val Ser Glu Glu  Pro Leu His Ala Gly  Gln Pro His 
    1760                 1765                 1770             


Phe Leu  Gln Ser Gln Leu Ala  Ala Gly Gln Leu Val  Tyr Ala His 
    1775                 1780                 1785             


Gly Gly  Gly Gly Thr Gln Gln  Asp Gly Phe His Phe  Arg Ala His 
    1790                 1795                 1800             


Leu Gln  Gly Pro Ala Gly Ala  Ser Val Ala Gly Pro  Gln Thr Ser 
    1805                 1810                 1815             


Glu Ala  Phe Ala Ile Thr Val  Arg Asp Val Asn Glu  Arg Pro Pro 
    1820                 1825                 1830             


Gln Pro  Gln Ala Ser Val Pro  Leu Arg Leu Thr Arg  Gly Ser Arg 
    1835                 1840                 1845             


Ala Pro  Ile Ser Arg Ala Gln  Leu Ser Val Val Asp  Pro Asp Ser 
    1850                 1855                 1860             


Ala Pro  Gly Glu Ile Glu Tyr  Glu Val Gln Arg Ala  Pro His Asn 
    1865                 1870                 1875             


Gly Phe  Leu Ser Leu Val Gly  Gly Gly Leu Gly Pro  Val Thr Arg 
    1880                 1885                 1890             


Phe Thr  Gln Ala Asp Val Asp  Ser Gly Arg Leu Ala  Phe Val Ala 
    1895                 1900                 1905             


Asn Gly  Ser Ser Val Ala Gly  Ile Phe Gln Leu Ser  Met Ser Asp 
    1910                 1915                 1920             


Gly Ala  Ser Pro Pro Leu Pro  Met Ser Leu Ala Val  Asp Ile Leu 
    1925                 1930                 1935             


Pro Ser  Ala Ile Glu Val Gln  Leu Arg Ala Pro Leu  Glu Val Pro 
    1940                 1945                 1950             


Gln Ala  Leu Gly Arg Ser Ser  Leu Ser Gln Gln Gln  Leu Arg Val 
    1955                 1960                 1965             


Val Ser  Asp Arg Glu Glu Pro  Glu Ala Ala Tyr Arg  Leu Ile Gln 
    1970                 1975                 1980             


Gly Pro  Gln Tyr Gly His Leu  Leu Val Gly Gly Arg  Pro Thr Ser 
    1985                 1990                 1995             


Ala Phe  Ser Gln Phe Gln Ile  Asp Gln Gly Glu Val  Val Phe Ala 
    2000                 2005                 2010             


Phe Thr  Asn Phe Ser Ser Ser  His Asp His Phe Arg  Val Leu Ala 
    2015                 2020                 2025             


Leu Ala  Arg Gly Val Asn Ala  Ser Ala Val Val Asn  Val Thr Val 
    2030                 2035                 2040             


Arg Ala  Leu Leu His Val Trp  Ala Gly Gly Pro Trp  Pro Gln Gly 
    2045                 2050                 2055             


Ala Thr  Leu Arg Leu Asp Pro  Thr Val Leu Asp Ala  Gly Glu Leu 
    2060                 2065                 2070             


Ala Asn  Arg Thr Gly Ser Val  Pro Arg Phe Arg Leu  Leu Glu Gly 
    2075                 2080                 2085             


Pro Arg  His Gly Arg Val Val  Arg Val Pro Arg Ala  Arg Thr Glu 
    2090                 2095                 2100             


Pro Gly  Gly Ser Gln Leu Val  Glu Gln Phe Thr Gln  Gln Asp Leu 
    2105                 2110                 2115             


Glu Asp  Gly Arg Leu Gly Leu  Glu Val Gly Arg Pro  Glu Gly Arg 
    2120                 2125                 2130             


Ala Pro  Gly Pro Ala Gly Asp  Ser Leu Thr Leu Glu  Leu Trp Ala 
    2135                 2140                 2145             


Gln Gly  Val Pro Pro Ala Val  Ala Ser Leu Asp Phe  Ala Thr Glu 
    2150                 2155                 2160             


Pro Tyr  Asn Ala Ala Arg Pro  Tyr Ser Val Ala Leu  Leu Ser Val 
    2165                 2170                 2175             


Pro Glu  Ala Ala Arg Thr Glu  Ala Gly Lys Pro Glu  Ser Ser Thr 
    2180                 2185                 2190             


Pro Thr  Gly Glu Pro Gly Pro  Met Ala Ser Ser Pro  Glu Pro Ala 
    2195                 2200                 2205             


Val Ala  Lys Gly Gly Phe Leu  Ser Phe Leu Glu Ala  Asn Met Phe 
    2210                 2215                 2220             


Ser Val  Ile Ile Pro Met Cys  Leu Val Leu Leu Leu  Leu Ala Leu 
    2225                 2230                 2235             


Ile Leu  Pro Leu Leu Phe Tyr  Leu Arg Lys Arg Asn  Lys Thr Gly 
    2240                 2245                 2250             


Lys His  Asp Val Gln Val Leu  Thr Ala Lys Pro Arg  Asn Gly Leu 
    2255                 2260                 2265             


Ala Gly  Asp Thr Glu Thr Phe  Arg Lys Val Glu Pro  Gly Gln Ala 
    2270                 2275                 2280             


Ile Pro  Leu Thr Ala Val Pro  Gly Gln Gly Pro Pro  Pro Gly Gly 
    2285                 2290                 2295             


Gln Pro  Asp Pro Glu Leu Leu  Gln Phe Cys Arg Thr  Pro Asn Pro 
    2300                 2305                 2310             


Ala Leu  Lys Asn Gly Gln Tyr  Trp Val 
    2315                 2320         


<210>  1181
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  1181

Met Lys Thr Trp Val Lys Ile Val Phe Gly Val Ala Thr Ser Ala Val 
1               5                   10                  15      


Leu Ala Leu Leu Val Met Cys Ile Val Leu Arg Pro Ser Arg Val His 
            20                  25                  30          


Asn Ser Glu Glu Asn Thr Met Arg Ala Leu Thr Leu Lys Asp Ile Leu 
        35                  40                  45              


Asn Gly Thr Phe Ser Tyr Lys Thr Phe Phe Pro Asn Trp Ile Ser Gly 
    50                  55                  60                  


Gln Glu Tyr Leu His Gln Ser Ala Asp Asn Asn Ile Val Leu Tyr Asn 
65                  70                  75                  80  


Ile Glu Thr Gly Gln Ser Tyr Thr Ile Leu Ser Asn Arg Thr Met Lys 
                85                  90                  95      


Ser Val Asn Ala Ser Asn Tyr Gly Leu Ser Pro Asp Arg Gln Phe Val 
            100                 105                 110         


Tyr Leu Glu Ser Asp Tyr Ser Lys Leu Trp Arg Tyr Ser Tyr Thr Ala 
        115                 120                 125             


Thr Tyr Tyr Ile Tyr Asp Leu Ser Asn Gly Glu Phe Val Arg Gly Asn 
    130                 135                 140                 


Glu Leu Pro Arg Pro Ile Gln Tyr Leu Cys Trp Ser Pro Val Gly Ser 
145                 150                 155                 160 


Lys Leu Ala Tyr Val Tyr Gln Asn Asn Ile Tyr Leu Lys Gln Arg Pro 
                165                 170                 175     


Gly Asp Pro Pro Phe Gln Ile Thr Phe Asn Gly Arg Glu Asn Lys Ile 
            180                 185                 190         


Phe Asn Gly Ile Pro Asp Trp Val Tyr Glu Glu Glu Met Leu Ala Thr 
        195                 200                 205             


Lys Tyr Ala Leu Trp Trp Ser Pro Asn Gly Lys Phe Leu Ala Tyr Ala 
    210                 215                 220                 


Glu Phe Asn Asp Thr Asp Ile Pro Val Ile Ala Tyr Ser Tyr Tyr Gly 
225                 230                 235                 240 


Asp Glu Gln Tyr Pro Arg Thr Ile Asn Ile Pro Tyr Pro Lys Ala Gly 
                245                 250                 255     


Ala Lys Asn Pro Val Val Arg Ile Phe Ile Ile Asp Thr Thr Tyr Pro 
            260                 265                 270         


Ala Tyr Val Gly Pro Gln Glu Val Pro Val Pro Ala Met Ile Ala Ser 
        275                 280                 285             


Ser Asp Tyr Tyr Phe Ser Trp Leu Thr Trp Val Thr Asp Glu Arg Val 
    290                 295                 300                 


Cys Leu Gln Trp Leu Lys Arg Val Gln Asn Val Ser Val Leu Ser Ile 
305                 310                 315                 320 


Cys Asp Phe Arg Glu Asp Trp Gln Thr Trp Asp Cys Pro Lys Thr Gln 
                325                 330                 335     


Glu His Ile Glu Glu Ser Arg Thr Gly Trp Ala Gly Gly Phe Phe Val 
            340                 345                 350         


Ser Thr Pro Val Phe Ser Tyr Asp Ala Ile Ser Tyr Tyr Lys Ile Phe 
        355                 360                 365             


Ser Asp Lys Asp Gly Tyr Lys His Ile His Tyr Ile Lys Asp Thr Val 
    370                 375                 380                 


Glu Asn Ala Ile Gln Ile Thr Ser Gly Lys Trp Glu Ala Ile Asn Ile 
385                 390                 395                 400 


Phe Arg Val Thr Gln Asp Ser Leu Phe Tyr Ser Ser Asn Glu Phe Glu 
                405                 410                 415     


Glu Tyr Pro Gly Arg Arg Asn Ile Tyr Arg Ile Ser Ile Gly Ser Tyr 
            420                 425                 430         


Pro Pro Ser Lys Lys Cys Val Thr Cys His Leu Arg Lys Glu Arg Cys 
        435                 440                 445             


Gln Tyr Tyr Thr Ala Ser Phe Ser Asp Tyr Ala Lys Tyr Tyr Ala Leu 
    450                 455                 460                 


Val Cys Tyr Gly Pro Gly Ile Pro Ile Ser Thr Leu His Asp Gly Arg 
465                 470                 475                 480 


Thr Asp Gln Glu Ile Lys Ile Leu Glu Glu Asn Lys Glu Leu Glu Asn 
                485                 490                 495     


Ala Leu Lys Asn Ile Gln Leu Pro Lys Glu Glu Ile Lys Lys Leu Glu 
            500                 505                 510         


Val Asp Glu Ile Thr Leu Trp Tyr Lys Met Ile Leu Pro Pro Gln Phe 
        515                 520                 525             


Asp Arg Ser Lys Lys Tyr Pro Leu Leu Ile Gln Val Tyr Gly Gly Pro 
    530                 535                 540                 


Cys Ser Gln Ser Val Arg Ser Val Phe Ala Val Asn Trp Ile Ser Tyr 
545                 550                 555                 560 


Leu Ala Ser Lys Glu Gly Met Val Ile Ala Leu Val Asp Gly Arg Gly 
                565                 570                 575     


Thr Ala Phe Gln Gly Asp Lys Leu Leu Tyr Ala Val Tyr Arg Lys Leu 
            580                 585                 590         


Gly Val Tyr Glu Val Glu Asp Gln Ile Thr Ala Val Arg Lys Phe Ile 
        595                 600                 605             


Glu Met Gly Phe Ile Asp Glu Lys Arg Ile Ala Ile Trp Gly Trp Ser 
    610                 615                 620                 


Tyr Gly Gly Tyr Val Ser Ser Leu Ala Leu Ala Ser Gly Thr Gly Leu 
625                 630                 635                 640 


Phe Lys Cys Gly Ile Ala Val Ala Pro Val Ser Ser Trp Glu Tyr Tyr 
                645                 650                 655     


Ala Ser Val Tyr Thr Glu Arg Phe Met Gly Leu Pro Thr Lys Asp Asp 
            660                 665                 670         


Asn Leu Glu His Tyr Lys Asn Ser Thr Val Met Ala Arg Ala Glu Tyr 
        675                 680                 685             


Phe Arg Asn Val Asp Tyr Leu Leu Ile His Gly Thr Ala Asp Asp Asn 
    690                 695                 700                 


Val His Phe Gln Asn Ser Ala Gln Ile Ala Lys Ala Leu Val Asn Ala 
705                 710                 715                 720 


Gln Val Asp Phe Gln Ala Met Trp Tyr Ser Asp Gln Asn His Gly Leu 
                725                 730                 735     


Ser Gly Leu Ser Thr Asn His Leu Tyr Thr His Met Thr His Phe Leu 
            740                 745                 750         


Lys Gln Cys Phe Ser Leu Ser Asp 
        755                 760 


<210>  1182
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  1182

Met Val Arg Tyr Arg Val Arg Ser Leu Ser Glu Arg Ser His Glu Val 
1               5                   10                  15      


Tyr Arg Gln Gln Leu His Gly Gln Glu Gln Gly His His Gly Gln Glu 
            20                  25                  30          


Glu Gln Gly Leu Ser Pro Glu His Val Glu Val Tyr Glu Arg Thr His 
        35                  40                  45              


Gly Gln Ser His Tyr Arg Arg Arg His Cys Ser Arg Arg Arg Leu His 
    50                  55                  60                  


Arg Ile His Arg Arg Gln His Arg Ser Cys Arg Arg Arg Lys Arg Arg 
65                  70                  75                  80  


Ser Cys Arg His Arg Arg Arg His Arg Arg Glu Ser Leu Gly Asp Pro 
                85                  90                  95      


Leu Asn Gln Asn Phe Leu Ser Gln Lys Ala Ala Glu Pro Gly Arg Glu 
            100                 105                 110         


His Ala Glu Gly Thr Lys Leu Pro Gly Pro Leu Thr Pro Ser Trp Lys 
        115                 120                 125             


Leu Arg Lys Ser Arg Pro Lys His Gln Val Arg Pro 
    130                 135                 140 


<210>  1183
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  1183

Ser His Ser Cys Val Val Arg Asp Trp Arg Cys Ile Leu Val Leu Val 
1               5                   10                  15      


Ile Thr Leu Met Trp Pro Gln Pro His Leu Pro Pro His Pro Met Met 
            20                  25                  30          


Ser Glu Lys Thr Arg Gln Asn Lys Leu Ala Glu Ala Lys Lys Lys Phe 
        35                  40                  45              


Thr Asp Tyr Arg Gln Trp Asn Ile Ala Gly Val Gly Thr Gly Ala Thr 
    50                  55                  60                  


Asp Thr Lys Lys Lys Lys Ile Asn His Gly Thr Asn Pro Glu Thr Thr 
65                  70                  75                  80  


Thr Ser Gly Gly Cys His Ser Pro Glu Asp Thr Gln Gln Asn Arg Ala 
                85                  90                  95      


Gln Leu Lys Glu Glu Lys Lys Met Arg Glu Gln Glu Asp Val Glu Thr 
            100                 105                 110         


Gly Gly Glu Ala Ala Gly Ala Gly Glu Ala Asp Val Gly Ala Gly Gly 
        115                 120                 125             


Glu Asp Ala Gly Ser Gly Ala Glu Asp Val Gly Pro Gly Gly Glu Asp 
    130                 135                 140                 


Val Gly Ala Gly Arg Glu Ala Ala Ala Glu Gly Gly Glu Asn Ala Gly 
145                 150                 155                 160 


Ala Glu Asp Val Ala Ala Gly Gly Glu Asp Ala Gly Gly Glu Glu Asp 
                165                 170                 175     


Ala Gly Ala Gly Glu Glu Asp Met Gly Pro Gly Glu Asp Ala Arg Gly 
            180                 185                 190         


Gly Glu His Ala Gly Ala Gly Glu Glu Asp Ala Gly Gly Gly Gly Asp 
        195                 200                 205             


Asp Ala Gly Ala Gly Gly Glu Asp Ala Gly Ala Gly Arg Lys Asp Ala 
    210                 215                 220                 


Gly Ala Gly Gly Gly Asp Val Gly Ala Gly Gly Glu Asp Val Gly Ala 
225                 230                 235                 240 


Gly Arg Glu Asp Val Gly Ala Ala Glu Ala Thr Gly Thr Glu Gly Glu 
                245                 250                 255     


Ala Val Gly Thr Arg Glu Asp Ala Gly Ala Gly Glu Asp Met Gly Ala 
            260                 265                 270         


Gly Gly Glu Asp Ala Gly Pro Gly Gly Glu Asp Ala Gly Pro Gly Gly 
        275                 280                 285             


Glu Asp Ala Gly Ala Gly Gly Glu Asp Ala Gly Ala Gly Gly Glu Asp 
    290                 295                 300                 


Val Gly Ala Gly Gly Glu Asp Val Gly Ala Gly Gly Glu Asp Val Gly 
305                 310                 315                 320 


Pro Gly Gly Glu Asp Val Gly Ala Gly Gly Glu Asp Val Gly Pro Gly 
                325                 330                 335     


Gly Glu Asp Ala Gly Gly Arg Arg Arg Arg Cys Gly Gly Arg Arg Arg 
            340                 345                 350         


Arg Cys Gly Ala Arg Arg Arg Arg Cys Gly Gly Arg Arg Arg Arg Cys 
        355                 360                 365             


Gly Gly Gln Glu Glu Lys Met Arg Gly Ala Gly Gly Glu Asp Ala Gly 
    370                 375                 380                 


Asp Arg Arg Arg Arg Cys Gly Gly Gln Glu Glu Lys Met Arg Glu Gln 
385                 390                 395                 400 


Glu Glu Lys Met Arg Glu Gln Glu Glu Lys Met Gln Gly Gln Glu Glu 
                405                 410                 415     


Lys Met Arg Glu Gln Glu Glu Lys Met Arg Gly Gln Glu Glu Lys Met 
            420                 425                 430         


Arg Glu Gln Glu Glu Lys Met Arg Gly Gln Glu Glu Lys Met Trp Gly 
        435                 440                 445             


Gln Glu Glu Lys Met Trp Gly Gln Glu Glu Lys Met Trp Gly Gln Glu 
    450                 455                 460                 


Glu Met Met Arg Glu Lys Glu Glu Arg Ile Asp Gln Lys Glu Lys Met 
465                 470                 475                 480 


Gln Glu Arg Leu Pro Glu His Glu Glu Arg Cys Ser Glu Pro Cys Leu 
                485                 490                 495     


Pro Pro Ser Lys Val Leu Cys Asn Met Ser His Thr Gly Ser Val Glu 
            500                 505                 510         


Pro Ala Gly Gly Glu Ala Gly Glu Gly Ser Pro Gln Asp Asn Pro Thr 
        515                 520                 525             


Ala Gln Glu Ile Met Gln Leu Phe Cys Gly Met Lys Asn Ala Gln Gln 
    530                 535                 540                 


Cys Pro Gly Leu Gly Ser Thr Ser Cys Ile Pro Phe Phe Tyr Arg Gly 
545                 550                 555                 560 


Asp Lys Arg Lys Met Lys Ile Ile Asn Ile Lys Leu Ala Leu Ser Thr 
                565                 570                 575     


Arg Pro Thr Glu Ala Ala Ala Met Ser Leu Cys Glu Tyr Ser Leu Ser 
            580                 585                 590         


Thr Asn Leu 
        595 


