                               SEQUENCE LISTING

<110> ARBOR BIOTECHNOLOGIES, INC.
 
<120> COMPOSITIONS COMPRISING A VARIANT POLYPEPTIDE AND USES THEREOF

<130> A2186-7046WO

<140>
<141>

<150> 63/294,224
<151> 2021-12-28

<150> 63/158,741
<151> 2021-03-09

<160> 28    

<170> PatentIn version 3.5

<210> 1
<211> 2235
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      parent sequence

<400> 1
atgatcaagt ctattcagct gaaggtcaag ggggagtgtc cgatcacgaa ggatgtaatc       60

aacgaataca aagaatacta taacaattgc agtgattgga ttaaaaacaa tctgacgtcc      120

attaccatcg gggagatggc aaaatttctg caatcgttga gcgataaaga agtggcctat      180

atctcaatgg gcctgtccga tgagtggaaa gacaaaccgt tatatcatct gtttaccaaa      240

aaatatcaca ccaaaaatgc ggataactta ttatactact acattaaaga aaaaaatctg      300

gacggctaca aaggcaatac gcttaatatc tccaatacat ctttccgcca gttcggttat      360

ttcaaactcg tggtgagcaa ctaccgcact aaaatccgta cgctgaattg taaaatcaag      420

cgtaagaaaa tcgatgccga ttccacgtct gaggatatcg aaatgcaggt gatgtacgaa      480

attattaaat acagtttaaa taaaaagtct gattgggata acttcattag ctatatcgaa      540

aacgttgaaa atcctaatat tgacaacatc aaccgctaca aactgctgcg cgaatgcttt      600

tgcgaaaacg aaaacatgat taagaacaaa cttgaattgc tgtctgtgga acaattgaaa      660

aaatttggcg gttgcatcat gaaacctcac attaatagca tgaccattaa cattcaagat      720

tttaaaattg aggaaaaaga aaactctctg gggttcatcc tccacctccc actgaacaaa      780

aaacagtatc aaattgaact cctgggcaat cgtcagatta aaaaaggcac caaagaaatt      840

cacgaaacgt tagttgacat tactaacacc catggcgaaa acattgtgtt tactattaaa      900

aatgataatc tgtatatcgt gttctcttat gagtccgaat ttgaaaaaga agaagttaac      960

ttcgctaaaa cggttggcct ggacgtaaac ttcaaacatg ccttctttgt gacctctgag     1020

aaagataact gtcatctcga cggttatatt aatctctaca aatacttatt ggagcacgac     1080

gagtttacta accttctcac cgaagatgaa cgtaaagatt atgaggagct gagtaaagtc     1140

gttactttct gcccgtttga aaatcagtta ctgtttgcgc gttacaacaa gatgagcaaa     1200

ttctgcaaga aagaacaggt cctgagcaaa cttctctatg cgctgcagaa aaaactcaaa     1260

gacgagaacc gcacgaaaga atatatttat gtctcgtgcg tgaacaaatt acgtgccaaa     1320

tatgtgtcat attttattct gaaagaaaag tactacgaga agcagaaaga atatgacatc     1380

gaaatgggct ttgtggacga ctcaacggaa agcaaagaat caatggataa acgccgtact     1440

gaatatccgt ttcgcaacac gccggtagcc aacgaactgt tgtccaaact gaataacgta     1500

cagcaggaca tcaacgggtg cctgaagaac atcatcaact acatttataa aattttcgag     1560

cagaacggtt ataaagttgt cgccctcgaa aacctggaaa attctaattt tgaaaaaaaa     1620

caggtgttgc cgacgattaa aagtctgctg aaatatcaca aactggagaa ccagaacgtg     1680

aatgatatca aggcctctga caaagttaaa gaatatattg aaaacggtta ttatgaactc     1740

atgaccaacg agaataacga aatcgttgat gcaaaatata cagaaaaggg cgcaatgaag     1800

gtgaagaacg ccaatttttt taacctcatg atgaaaagtt tgcattttgc cagtgtgaaa     1860

gatgagtttg tgctgctgtc caataatggc aagacgcaga ttgcattagt gccatccgag     1920

tttacatctc agatggacag caccgatcac tgtctgtaca tgaagaagaa cgacaaaggt     1980

aaactggtga aagcggataa aaaggaagtt cgtacaaaac aggaacgtca catcaacggc     2040

ctcaacgccg atttcaacgc agcgaataat attaaatata tcgtggaaaa tgaagtgtgg     2100

cgtggtattt tttgcactcg cccgaagaaa acagaatata acgtacccag tctggatacc     2160

acgaaaaaag gtccgtctgc gattctcaac atgctgaaga aaattgaagc catcaaggtc     2220

ctggaaacgg aaaaa                                                      2235


<210> 2
<211> 2235
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      parent sequence

<400> 2
atgatcaaga gcatccagct gaaggtgaag ggcgagtgcc ccatcaccaa ggacgtgatc       60

aacgagtaca aggagtacta caacaactgt tctgattgga tcaagaacaa tctgaccagc      120

atcacaatcg gcgagatggc caagtttctg cagagcctgt ccgacaagga ggtggcctac      180

atctctatgg gcctgagcga cgagtggaag gataagcctc tgtatcacct gttcaccaag      240

aagtaccaca caaagaatgc cgacaacctg ctgtactatt acatcaagga gaagaacctg      300

gatggctaca agggcaatac cctgaacatc tccaatacat ctttcaggca gtttggctat      360

ttcaagctgg tggtgtccaa ttacaggacc aagatccgca cactgaactg caagatcaag      420

cgcaagaaga tcgacgccga ttctaccagc gaggacatcg agatgcaggt catgtatgag      480

atcatcaagt actccctgaa caagaagtct gattgggata atttcatctc ttatatcgag      540

aacgtggaga accccaatat cgataacatc aatcggtaca agctgctgag agagtgcttt      600

tgtgagaacg agaatatgat caagaacaag ctggagctgc tgagcgtgga gcagctgaag      660

aagttcggcg gctgtatcat gaagcctcac atcaacagca tgaccatcaa tatccaggac      720

tttaagatcg aggagaagga gaattccctg ggcttcatcc tgcacctgcc actgaacaag      780

aagcagtacc agatcgagct gctgggcaat cggcagatca agaagggcac caaggagatc      840

cacgagacac tggtggacat caccaacaca cacggcgaga acatcgtgtt tacaatcaag      900

aacgataatc tgtacatcgt gtttagctac gagtccgagt tcgagaagga ggaagtgaat      960

tttgccaaga ccgtgggcct ggacgtgaac ttcaagcacg ccttctttgt gacatccgag     1020

aaggacaatt gccacctgga tggctatatc aacctgtata agtacctgct ggagcacgat     1080

gagttcacca acctgctgac agaggacgag cggaaggatt acgaggagct gtctaaggtg     1140

gtgacctttt gccctttcga gaatcagctg ctgtttgcca gatataacaa gatgagcaag     1200

ttctgtaaga aggagcaggt gctgtccaag ctgctgtacg ccctgcagaa gaagctgaag     1260

gacgagaaca ggacaaagga gtatatctac gtgtcttgcg tgaataagct gcgcgccaag     1320

tatgtgagct actttatcct gaaggagaag tattacgaga agcagaagga gtatgacatc     1380

gagatgggct tcgtggacga ttctaccgag agcaaggagt ccatggataa gcggagaacc     1440

gagtacccct ttaggaacac acctgtggcc aatgagctgc tgagcaagct gaacaatgtg     1500

cagcaggata tcaacggctg tctgaagaac atcatcaatt acatctacaa gatcttcgag     1560

cagaacggct acaaggtggt ggccctggag aacctggaga actccaattt cgagaagaag     1620

caggtgctgc caacaatcaa gtctctgctg aagtatcaca agctggagaa ccagaatgtg     1680

aacgacatca aggccagcga taaggtgaag gagtacatcg agaatggcta ttacgagctg     1740

atgaccaacg agaacaatga gatcgtggac gccaagtata cagagaaggg cgccatgaag     1800

gtgaagaatg ccaacttctt taacctgatg atgaagagcc tgcactttgc ctccgtgaag     1860

gatgagttcg tgctgctgtc caacaatggc aagacccaga tcgccctggt gccatccgag     1920

ttcacctctc agatggacag cacagatcac tgcctgtaca tgaagaagaa tgacaagggc     1980

aagctggtga aggccgataa gaaggaggtg aggacaaagc aggagcgcca catcaacggc     2040

ctgaatgccg actttaacgc cgccaacaat atcaagtata tcgtggagaa tgaagtgtgg     2100

cggggcatct tctgtaccag accaaagaag acagagtaca acgtgccctc cctggatacc     2160

acaaagaagg gcccctctgc catcctgaat atgctgaaga agatcgaggc catcaaggtg     2220

ctggagaccg agaag                                                      2235


<210> 3
<211> 745
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      parent sequence

<400> 3
Met Ile Lys Ser Ile Gln Leu Lys Val Lys Gly Glu Cys Pro Ile Thr 
1               5                   10                  15      


Lys Asp Val Ile Asn Glu Tyr Lys Glu Tyr Tyr Asn Asn Cys Ser Asp 
            20                  25                  30          


Trp Ile Lys Asn Asn Leu Thr Ser Ile Thr Ile Gly Glu Met Ala Lys 
        35                  40                  45              


Phe Leu Gln Ser Leu Ser Asp Lys Glu Val Ala Tyr Ile Ser Met Gly 
    50                  55                  60                  


Leu Ser Asp Glu Trp Lys Asp Lys Pro Leu Tyr His Leu Phe Thr Lys 
65                  70                  75                  80  


Lys Tyr His Thr Lys Asn Ala Asp Asn Leu Leu Tyr Tyr Tyr Ile Lys 
                85                  90                  95      


Glu Lys Asn Leu Asp Gly Tyr Lys Gly Asn Thr Leu Asn Ile Ser Asn 
            100                 105                 110         


Thr Ser Phe Arg Gln Phe Gly Tyr Phe Lys Leu Val Val Ser Asn Tyr 
        115                 120                 125             


Arg Thr Lys Ile Arg Thr Leu Asn Cys Lys Ile Lys Arg Lys Lys Ile 
    130                 135                 140                 


Asp Ala Asp Ser Thr Ser Glu Asp Ile Glu Met Gln Val Met Tyr Glu 
145                 150                 155                 160 


Ile Ile Lys Tyr Ser Leu Asn Lys Lys Ser Asp Trp Asp Asn Phe Ile 
                165                 170                 175     


Ser Tyr Ile Glu Asn Val Glu Asn Pro Asn Ile Asp Asn Ile Asn Arg 
            180                 185                 190         


Tyr Lys Leu Leu Arg Glu Cys Phe Cys Glu Asn Glu Asn Met Ile Lys 
        195                 200                 205             


Asn Lys Leu Glu Leu Leu Ser Val Glu Gln Leu Lys Lys Phe Gly Gly 
    210                 215                 220                 


Cys Ile Met Lys Pro His Ile Asn Ser Met Thr Ile Asn Ile Gln Asp 
225                 230                 235                 240 


Phe Lys Ile Glu Glu Lys Glu Asn Ser Leu Gly Phe Ile Leu His Leu 
                245                 250                 255     


Pro Leu Asn Lys Lys Gln Tyr Gln Ile Glu Leu Leu Gly Asn Arg Gln 
            260                 265                 270         


Ile Lys Lys Gly Thr Lys Glu Ile His Glu Thr Leu Val Asp Ile Thr 
        275                 280                 285             


Asn Thr His Gly Glu Asn Ile Val Phe Thr Ile Lys Asn Asp Asn Leu 
    290                 295                 300                 


Tyr Ile Val Phe Ser Tyr Glu Ser Glu Phe Glu Lys Glu Glu Val Asn 
305                 310                 315                 320 


Phe Ala Lys Thr Val Gly Leu Asp Val Asn Phe Lys His Ala Phe Phe 
                325                 330                 335     


Val Thr Ser Glu Lys Asp Asn Cys His Leu Asp Gly Tyr Ile Asn Leu 
            340                 345                 350         


Tyr Lys Tyr Leu Leu Glu His Asp Glu Phe Thr Asn Leu Leu Thr Glu 
        355                 360                 365             


Asp Glu Arg Lys Asp Tyr Glu Glu Leu Ser Lys Val Val Thr Phe Cys 
    370                 375                 380                 


Pro Phe Glu Asn Gln Leu Leu Phe Ala Arg Tyr Asn Lys Met Ser Lys 
385                 390                 395                 400 


Phe Cys Lys Lys Glu Gln Val Leu Ser Lys Leu Leu Tyr Ala Leu Gln 
                405                 410                 415     


Lys Lys Leu Lys Asp Glu Asn Arg Thr Lys Glu Tyr Ile Tyr Val Ser 
            420                 425                 430         


Cys Val Asn Lys Leu Arg Ala Lys Tyr Val Ser Tyr Phe Ile Leu Lys 
        435                 440                 445             


Glu Lys Tyr Tyr Glu Lys Gln Lys Glu Tyr Asp Ile Glu Met Gly Phe 
    450                 455                 460                 


Val Asp Asp Ser Thr Glu Ser Lys Glu Ser Met Asp Lys Arg Arg Thr 
465                 470                 475                 480 


Glu Tyr Pro Phe Arg Asn Thr Pro Val Ala Asn Glu Leu Leu Ser Lys 
                485                 490                 495     


Leu Asn Asn Val Gln Gln Asp Ile Asn Gly Cys Leu Lys Asn Ile Ile 
            500                 505                 510         


Asn Tyr Ile Tyr Lys Ile Phe Glu Gln Asn Gly Tyr Lys Val Val Ala 
        515                 520                 525             


Leu Glu Asn Leu Glu Asn Ser Asn Phe Glu Lys Lys Gln Val Leu Pro 
    530                 535                 540                 


Thr Ile Lys Ser Leu Leu Lys Tyr His Lys Leu Glu Asn Gln Asn Val 
545                 550                 555                 560 


Asn Asp Ile Lys Ala Ser Asp Lys Val Lys Glu Tyr Ile Glu Asn Gly 
                565                 570                 575     


Tyr Tyr Glu Leu Met Thr Asn Glu Asn Asn Glu Ile Val Asp Ala Lys 
            580                 585                 590         


Tyr Thr Glu Lys Gly Ala Met Lys Val Lys Asn Ala Asn Phe Phe Asn 
        595                 600                 605             


Leu Met Met Lys Ser Leu His Phe Ala Ser Val Lys Asp Glu Phe Val 
    610                 615                 620                 


Leu Leu Ser Asn Asn Gly Lys Thr Gln Ile Ala Leu Val Pro Ser Glu 
625                 630                 635                 640 


Phe Thr Ser Gln Met Asp Ser Thr Asp His Cys Leu Tyr Met Lys Lys 
                645                 650                 655     


Asn Asp Lys Gly Lys Leu Val Lys Ala Asp Lys Lys Glu Val Arg Thr 
            660                 665                 670         


Lys Gln Glu Arg His Ile Asn Gly Leu Asn Ala Asp Phe Asn Ala Ala 
        675                 680                 685             


Asn Asn Ile Lys Tyr Ile Val Glu Asn Glu Val Trp Arg Gly Ile Phe 
    690                 695                 700                 


Cys Thr Arg Pro Lys Lys Thr Glu Tyr Asn Val Pro Ser Leu Asp Thr 
705                 710                 715                 720 


Thr Lys Lys Gly Pro Ser Ala Ile Leu Asn Met Leu Lys Lys Ile Glu 
                725                 730                 735     


Ala Ile Lys Val Leu Glu Thr Glu Lys 
            740                 745 


<210> 4
<211> 36
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 4
cuuguuguau auguccuuuu auagguauua aacaac                                 36


<210> 5
<211> 36
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
cuuguuguau auacgcuuuu auagguauua aacaac                                 36


<210> 6
<211> 36
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
cuuguuguau auacgcuuuu auagguauug aacaac                                 36


<210> 7
<211> 36
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
cuuguuguau auauccuuuu auagauauua aacagc                                 36


<210> 8
<211> 36
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
cuuguuguau auauccuuuu auagauguug aacaac                                 36


<210> 9
<211> 36
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 9
cuuguuguau auauccuuuu auagguguug aacaac                                 36


<210> 10
<211> 36
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
cuuguuguau auauccuuuu auggguguau aacaac                                 36


<210> 11
<211> 37
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
cuuguuguau auguccuuuu auagguauuu gaacaac                                37


<210> 12
<211> 36
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
cuuguuguau augucuuuuu auagguauug aacaac                                 36


<210> 13
<211> 36
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
cuuguugugu auauccuuuu auagguauug aacaac                                 36


<210> 14
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
cuuguuguru au                                                           12


<210> 15
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
uuuuaurgru ru                                                           12


<210> 16
<211> 20
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      EMX1 Mammalian target sequence

<400> 16
ccgccgcttc ctgagccatc                                                   20


<210> 17
<211> 56
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 17
cuuguuguau auguccuuuu auagguauua aacaacccgc cgcuuccuga gccauc           56


<210> 18
<211> 20
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      VEGFA Mammalian target sequence

<400> 18
tccagaccac caatgggcac                                                   20


<210> 19
<211> 56
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
cuuguuguau auguccuuuu auagguauua aacaacucca gaccaccaau gggcac           56


<210> 20
<211> 20
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      AAVS1 Mammalian target sequence

<400> 20
tgagaatggt gcgtcctagg                                                   20


<210> 21
<211> 2235
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      parent sequence

<400> 21
atgattaaat ccatccagct taaagtgaaa ggcgaatgcc ccatcaccaa agatgttatt       60

aacgagtaca aggaatacta taataactgc agcgattgga taaaaaacaa tcttacctcg      120

atcactattg gcgagatggc caagttcctg cagagcctgt ctgataagga ggttgcttac      180

atttccatgg gcctgagcga cgagtggaaa gacaagccct tgtaccacct gttcactaag      240

aaataccaca ctaagaatgc tgacaatctg ctctactact acatcaagga gaaaaacttg      300

gatggctaca aggggaacac gcttaacatt tctaacacct catttcgtca gttcgggtat      360

ttcaagctcg tggtgtccaa ctatcgcact aagattcgga cactcaactg caagattaaa      420

cgaaagaaga tcgacgcaga ttctacgagc gaggatattg aaatgcaggt catgtatgaa      480

atcatcaagt actctctgaa taagaagtct gactgggaca attttatcag ctacatcgaa      540

aacgtagaga accctaacat agacaatatc aacaggtaca aactgcttag ggaatgcttc      600

tgtgaaaacg agaatatgat aaaaaacaag ctggagctgc tgagcgtgga gcaattaaag      660

aagtttggag ggtgtatcat gaaaccccac attaactcga tgacaattaa tattcaagac      720

ttcaagatag aggagaaaga aaacagcttg ggctttattc tccatctccc tctgaataaa      780

aaacagtacc agatcgagct attgggaaat agacagatta agaaagggac caaggaaatt      840

cacgaaactc tcgtcgatat cacaaacacc catggagaga acatcgtgtt cacaatcaag      900

aacgataatc tgtacatagt gtttagttat gagagcgagt tcgagaagga agaggtcaac      960

tttgccaaga ctgttgggct tgacgtcaat ttcaaacacg cgttcttcgt gacaagcgaa     1020

aaggacaact gccatctcga tggctacatt aacctatata agtatttgct cgaacacgac     1080

gagtttacaa acctgctgac agaagatgag agaaaggact acgaagaact cagtaaggtc     1140

gttacgttct gtccatttga aaatcagctg ctattcgccc ggtacaataa aatgtccaaa     1200

ttctgtaaga aggaacaggt attgtctaaa ctgctgtatg ccctgcagaa aaagttgaaa     1260

gatgagaatc ggaccaaaga gtatatctat gtctcatgcg tgaacaagct aagagctaag     1320

tatgtttcct atttcatact gaaggagaag tactatgaga agcaaaagga gtacgacatt     1380

gagatgggct tcgtcgatga ctcaaccgaa tctaaagaat ccatggacaa aaggcgcaca     1440

gagtatccat ttagaaatac accggtggct aacgaactcc tgagtaaact caacaatgtt     1500

caacaagata tcaacggttg tctgaagaat ataattaatt atatctataa gatttttgaa     1560

cagaatggct acaaggtggt cgcactggaa aacttagaga attccaactt tgagaaaaag     1620

caggtgcttc ctacaatcaa atcacttctg aagtaccaca aacttgagaa tcagaacgta     1680

aatgatatca aagccagtga taaagtcaaa gaatacatcg agaatggtta ttatgaactg     1740

atgactaatg aaaataatga aatagtggac gcaaaatata cggaaaaggg tgccatgaag     1800

gtaaagaacg caaacttttt taatttgatg atgaagtcac tgcactttgc ttctgtgaag     1860

gatgagtttg tcctgctgag caacaacgga aagacacaga ttgcgctagt gccttcagag     1920

ttcactagtc agatggacag taccgaccat tgcctctaca tgaaaaaaaa tgacaaaggg     1980

aaactcgtga aggctgacaa gaaagaggtg cggaccaagc aagagcgcca tatcaatgga     2040

ttaaacgccg attttaacgc ggcaaataac atcaaataca tcgttgaaaa tgaggtgtgg     2100

aggggtatct tctgtacccg accaaagaag actgagtaca acgtaccatc cttagacacc     2160

accaaaaaag gaccctccgc cattctgaat atgttaaaga aaatcgaggc cataaaagtg     2220

ttggagaccg agaag                                                      2235


<210> 22
<211> 2235
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      parent sequence

<400> 22
atgatcaaga gcattcagct gaaggtgaag ggcgagtgcc ccatcaccaa ggacgtgatc       60

aacgagtaca aggagtacta caacaactgc agcgactgga ttaaaaacaa tctcacaagc      120

atcaccatcg gcgagatggc caagttcctg cagagcctga gcgacaaaga ggtggcctac      180

atcagcatgg gcctgagcga cgagtggaag gacaagcccc tgtaccacct gttcaccaag      240

aagtaccaca ccaagaacgc cgacaacctg ctgtactact acatcaagga gaagaatctg      300

gatggctaca agggcaatac cctgaacatc agcaacacca gcttcagaca gttcggctac      360

ttcaagctgg tggtgagcaa ctacagaacc aagatcagaa ccctgaactg caagatcaag      420

agaaagaaga tcgacgccga cagcacaagc gaggacatag agatgcaagt tatgtacgag      480

atcatcaagt acagccttaa taaaaagagc gactgggaca acttcatcag ctacatagaa      540

aacgtggaga accccaacat cgacaacatc aacagataca agctgctgag agagtgcttc      600

tgcgagaacg agaacatgat caaaaacaaa ctcgaactgc tgagtgtaga acagctgaag      660

aagttcggcg gctgcatcat gaagccccac atcaacagca tgaccatcaa catccaagac      720

ttcaagatcg aggagaagga gaacagcctg ggcttcatcc tgcacctgcc cttaaacaag      780

aagcagtatc agatcgagct gctgggcaac agacagatca agaagggcac caaggagatc      840

cacgagaccc tggtggacat caccaacacc cacggcgaga atatcgtttt cactatcaag      900

aacgacaacc tgtacatcgt gtttagctat gagagcgagt tcgagaagga agaggtgaac      960

ttcgccaaga ccgtgggcct ggacgtgaac ttcaagcacg ccttcttcgt gacaagcgag     1020

aaggacaact gccacctgga cggctacatc aatctgtaca agtacctgct ggagcacgac     1080

gagttcacca acctgctgac cgaggacgag agaaaggact acgaggagct gagcaaggtg     1140

gtgaccttct gccccttcga gaatcagctg ctgttcgcta gatacaacaa gatgagcaag     1200

ttctgcaaga aggagcaagt gctgagcaaa ctgctgtacg ccctgcagaa gaagctgaag     1260

gacgagaaca gaaccaagga gtatatctac gtgagctgcg tgaacaagct gagagccaag     1320

tacgtgagct acttcatcct gaaggagaag tactacgaga agcagaagga gtacgacatc     1380

gagatgggtt ttgtggacga cagcaccgag agcaaggaga gcatggacaa gagaagaacc     1440

gagtacccct tcagaaacac ccccgtggcc aacgaattac tgtctaaact gaataacgtg     1500

cagcaagaca tcaacggctg cctgaagaac ataatcaact acatctacaa gatcttcgag     1560

cagaacggct acaaggtggt agccctggag aacctggaga acagcaactt cgagaagaag     1620

caagtgctgc ccaccatcaa gagcctgctg aagtaccaca agctggagaa tcagaacgtg     1680

aacgacatca aggctagcga caaggtgaag gagtacatcg agaacggata ctacgagctg     1740

atgaccaacg agaacaacga gatcgtggac gccaagtaca ccgagaaggg cgccatgaag     1800

gtgaagaacg ccaacttctt caacctgatg atgaagagcc tgcacttcgc tagcgtgaag     1860

gacgagttcg tgctgctgtc gaacaacggc aagacacaga tcgccctggt gcctagcgag     1920

ttcacatctc agatggacag caccgaccac tgcctgtaca tgaagaagaa cgacaagggc     1980

aagctggtga aggccgacaa gaaagaggtg agaaccaagc aagagagaca catcaacggc     2040

ctgaacgccg acttcaacgc cgccaacaac atcaagtaca tcgtggagaa cgaggtgtgg     2100

agaggcatct tctgcacaag acccaagaag accgagtaca acgtgcctag cctggacacc     2160

accaagaagg gccctagcgc catcctgaac atgctgaaga agatcgaggc catcaaggtg     2220

ctggagaccg agaag                                                      2235


<210> 23
<211> 2235
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      parent sequence

<400> 23
atgatcaaga gcatccagct gaaggtgaag ggcgagtgcc ccatcaccaa ggacgtgatc       60

aacgagtaca aggagtacta caacaactgc agcgactgga tcaagaacaa cctgaccagc      120

atcaccatcg gcgagatggc caagttcctg cagagcctga gcgacaagga ggtggcctac      180

atcagcatgg gcctgagcga cgagtggaag gacaagcccc tgtaccacct gttcaccaag      240

aagtaccaca ccaagaacgc cgacaacctg ctgtactact acatcaagga gaagaacctg      300

gacggctaca agggcaacac cctgaacatc agcaacacca gcttccggca gttcggctac      360

ttcaagctgg tggtgagcaa ctaccggacc aagatccgga ccctgaactg caagatcaag      420

cggaagaaga tcgacgccga cagcaccagc gaggacatcg agatgcaggt gatgtacgag      480

atcatcaagt acagcctgaa caagaagagc gactgggaca acttcatcag ctacatcgag      540

aacgtggaga accccaacat cgacaacatc aaccggtaca agctgctgcg ggagtgcttc      600

tgcgagaacg agaacatgat caagaacaag ctggagctgc tgagcgtgga gcagctgaag      660

aagttcggcg gctgcatcat gaagccccac atcaacagca tgaccatcaa catccaggac      720

ttcaagatcg aggagaagga gaacagcctg ggcttcatcc tgcacctgcc cctgaacaag      780

aagcagtacc agatcgagct gctgggcaac cggcagatca agaagggcac caaggagatc      840

cacgagaccc tggtggacat caccaacacc cacggcgaga acatcgtgtt caccatcaag      900

aacgacaacc tgtacatcgt gttcagctac gagagcgagt tcgagaagga ggaggtgaac      960

ttcgccaaga ccgtgggcct ggacgtgaac ttcaagcacg ccttcttcgt gaccagcgag     1020

aaggacaact gccacctgga cggctacatc aacctgtaca agtacctgct ggagcacgac     1080

gagttcacca acctgctgac cgaggacgag cggaaggact acgaggagct gagcaaggtg     1140

gtgaccttct gccccttcga gaaccagctg ctgttcgccc ggtacaacaa gatgagcaag     1200

ttctgcaaga aggagcaggt gctgagcaag ctgctgtacg ccctgcagaa gaagctgaag     1260

gacgagaacc ggaccaagga gtacatctac gtgagctgcg tgaacaagct gcgggccaag     1320

tacgtgagct acttcatcct gaaggagaag tactacgaga agcagaagga gtacgacatc     1380

gagatgggct tcgtggacga cagcaccgag agcaaggaga gcatggacaa gcggcggacc     1440

gagtacccct tccggaacac ccccgtggcc aacgagctgc tgagcaagct gaacaacgtg     1500

cagcaggaca tcaacggctg cctgaagaac atcatcaact acatctacaa gatcttcgag     1560

cagaacggct acaaggtggt ggccctggag aacctggaga acagcaactt cgagaagaag     1620

caggtgctgc ccaccatcaa gagcctgctg aagtaccaca agctggagaa ccagaacgtg     1680

aacgacatca aggccagcga caaggtgaag gagtacatcg agaacggcta ctacgagctg     1740

atgaccaacg agaacaacga gatcgtggac gccaagtaca ccgagaaggg cgccatgaag     1800

gtgaagaacg ccaacttctt caacctgatg atgaagagcc tgcacttcgc cagcgtgaag     1860

gacgagttcg tgctgctgag caacaacggc aagacccaga tcgccctggt gcccagcgag     1920

ttcaccagcc agatggacag caccgaccac tgcctgtaca tgaagaagaa cgacaagggc     1980

aagctggtga aggccgacaa gaaggaggtg cggaccaagc aggagcggca catcaacggc     2040

ctgaacgccg acttcaacgc cgccaacaac atcaagtaca tcgtggagaa cgaggtgtgg     2100

cggggcatct tctgcacccg gcccaagaag accgagtaca acgtgcccag cctggacacc     2160

accaagaagg gccccagcgc catcctgaac atgctgaaga agatcgaggc catcaaggtg     2220

ctggagaccg agaag                                                      2235


<210> 24
<211> 2235
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      parent sequence

<400> 24
atgattaaaa gtatacagct taaggtcaag ggcgagtgcc cgattaccaa agatgtaatt       60

aacgagtaca aggagtatta caataactgt tctgactgga tcaagaacaa tctgacttca      120

attacgatcg gtgaaatggc caaatttctc cagtccttga gtgataagga ggtcgcatat      180

atatccatgg gactcagtga cgagtggaag gacaaacccc tgtaccatct ttttactaaa      240

aaataccata cgaaaaacgc agacaacctg ctgtactact atataaaaga aaaaaacctg      300

gacggttaca agggcaacac cctcaatatt agcaacacta gtttccgaca attcgggtac      360

ttcaagctgg tcgtgagcaa ctatcggacc aaaatcagga ctttgaattg taagataaag      420

agaaagaaga tagacgcaga ttctactagt gaggatatcg agatgcaggt aatgtacgag      480

atcattaagt attcactgaa caagaagagc gattgggata acttcatatc atacatcgaa      540

aacgttgaaa atccaaacat cgacaatatt aatagataca aactgttgag agaatgcttc      600

tgcgaaaacg aaaatatgat aaaaaacaaa ctcgaattgt tgtcagttga acagctgaag      660

aaattcggag ggtgcataat gaagcctcac ataaactcaa tgacaataaa catccaagac      720

ttcaagatag aagagaagga gaacagtttg ggttttattc ttcacctgcc tttgaacaag      780

aagcaatacc aaatcgagct gctcggaaat aggcagataa aaaaggggac aaaagaaata      840

cacgaaaccc ttgttgacat tacgaacaca cacggggaaa atatcgtgtt cacaattaaa      900

aatgacaacc tttacattgt attttcttat gaatcagagt tcgaaaagga agaagtgaac      960

tttgccaaga ccgttggttt ggacgtcaac tttaaacacg ccttcttcgt tacatcagaa     1020

aaggataact gtcatcttga tggatacata aacctctaca agtatcttct tgaacacgac     1080

gaattcacaa acctgcttac tgaagacgag cgaaaggatt acgaggagtt gtcaaaggta     1140

gtcacattct gtccattcga aaatcagctg ttgtttgcca ggtacaataa gatgtctaaa     1200

ttctgtaaaa aagaacaagt cctcagcaaa ctgctgtatg cactgcaaaa gaaacttaag     1260

gacgaaaata ggactaagga gtatatatac gtttcatgcg ttaataaact ccgggcgaaa     1320

tatgtgagtt attttattct gaaggagaag tattatgaga agcagaaaga gtacgacata     1380

gaaatgggat ttgtggatga cagtacggag agcaaagaaa gcatggacaa aagaaggacc     1440

gaatatccat ttcgaaatac tccagtcgcg aatgagctgc tgagcaaact taacaatgtc     1500

cagcaggaca ttaacggttg cctgaagaac ataatcaact acatatataa gatatttgag     1560

caaaacggat acaaagtggt tgcacttgaa aacctcgaga attcaaattt cgaaaagaag     1620

caagttttgc ccacgattaa aagtctcttg aaataccata agctcgaaaa tcagaatgtg     1680

aacgatatca aggcctcaga taaggtcaag gagtacatcg aaaatggata ttacgagctg     1740

atgacgaacg agaataacga aatcgtcgat gcgaagtaca cagaaaaggg ggctatgaag     1800

gtgaaaaacg ccaatttttt taatttgatg atgaagtcct tgcatttcgc ctcagtcaaa     1860

gatgagtttg ttctcctgag taataatggg aaaacacaga tagccttggt tccttcagag     1920

ttcacgtctc agatggactc aactgatcat tgtctttata tgaagaaaaa tgataaaggg     1980

aaactggtca aggccgataa gaaagaggtg cgcacgaaac aagaaagaca catcaacggc     2040

ctcaacgccg attttaacgc agctaacaat attaaatata tcgtagagaa tgaggtctgg     2100

aggggcattt tttgcacccg acccaagaag actgaataca atgtccctag tctcgatacg     2160

accaaaaagg ggccatcagc tatactgaat atgttgaaaa agattgaggc gattaaagtc     2220

ctggaaaccg agaaa                                                      2235


<210> 25
<211> 2235
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      parent sequence

<400> 25
atgatcaaga gcatccagct gaaggtgaag ggagaatgtc ctatcacaaa ggacgtgatc       60

aacgagtaca aggagtacta caacaactgc agcgattgga tcaagaacaa cctgaccagc      120

atcaccatcg gcgagatggc caagttcctg cagtctctgt ccgataagga agtcgcctac      180

atcagcatgg gcttgagcga cgaatggaag gacaaacccc tgtaccatct gttcactaag      240

aagtaccaca ccaagaacgc cgataacctg ctgtactact acatcaagga aaagaacctg      300

gacggctaca agggcaatac cctgaacatc agtaacacca gcttccggca gtttggctat      360

tttaaactgg tggtcagcaa ctacagaacc aagatcagaa cactgaactg caagatcaag      420

aggaagaaaa tcgacgccga ctccaccagc gaagatatag agatgcaggt gatgtacgag      480

atcattaagt actccctgaa taagaagtct gactgggaca acttcatcag ctacatcgag      540

aacgtggaaa accccaacat tgacaatatc aacagataca agctgctgcg ggaatgcttc      600

tgcgagaatg aaaacatgat caagaacaag ctggagcttc tgagcgtgga gcagctgaag      660

aaattcggcg gatgtatcat gaagccacac atcaatagca tgaccatcaa catccaggac      720

ttcaaaattg aagaaaagga gaatagccta ggcttcatcc tgcacctgcc tctgaacaag      780

aaacagtacc agatcgagct gctgggcaac cggcaaatca agaagggcac caaggagatc      840

cacgagacac tggtcgacat cacaaacaca cacggcgaaa acatcgtgtt caccatcaag      900

aacgacaacc tgtacatcgt gttcagctac gagtctgaat tcgagaagga agaggtcaac      960

ttcgctaaga cagtgggcct ggacgtgaac ttcaagcacg ccttcttcgt gaccagcgag     1020

aaagacaact gtcacctgga cgggtacatc aacctgtaca agtacctgct ggaacacgac     1080

gagttcacca acctcctgac cgaagatgaa cggaaggatt acgaggagct gtctaaggtg     1140

gtgacattct gccctttcga gaaccagctg ctcttcgcca gatataacaa gatgagcaag     1200

ttttgtaaaa aggagcaggt gctcagcaag ctactgtacg ccctgcagaa gaagctgaag     1260

gacgagaaca gaaccaagga atacatctac gtgagctgcg tgaacaagct gagagccaag     1320

tacgtgtcct atttcatcct gaaggaaaaa tactacgaga aacagaaaga gtacgacatc     1380

gagatgggat ttgtggacga cagcaccgaa agcaaggaat ctatggacaa gcgcagaacc     1440

gagtatccat ttagaaacac ccctgtggcc aatgagctgc tgtccaaact gaacaacgtg     1500

cagcaggata tcaatggctg cctgaaaaac atcatcaact acatttacaa gatctttgag     1560

caaaacggct acaaagtggt ggccctggag aacctggaaa actccaactt cgagaagaag     1620

caagtgctgc ccacaatcaa gagcctgctg aagtaccata agctggaaaa tcagaatgtg     1680

aacgacataa aggcctctga taaggtgaag gaatacatcg aaaatggcta ttacgagctg     1740

atgaccaacg aaaataacga gattgtggac gctaaataca ccgagaaggg cgctatgaaa     1800

gtgaaaaacg ctaacttttt taacctgatg atgaagagcc tgcacttcgc cagcgtgaag     1860

gacgagttcg tgctgctgag caacaacggc aagacacaga tcgccctggt gcccagcgag     1920

ttcaccagtc agatggattc tacagatcac tgcctgtaca tgaaaaagaa tgataaggga     1980

aagttagtga aagccgataa gaaggaggtg cggaccaaac aggagagaca catcaacggc     2040

ctgaacgctg acttcaacgc cgccaacaac atcaaataca tcgttgagaa tgaggtgtgg     2100

cggggcatct tctgcaccag acctaagaaa acagagtata atgtgcctag cctggacacc     2160

accaagaagg gtcctagcgc catcctgaac atgctgaaga agatcgaggc catcaaggtt     2220

ctggaaaccg agaag                                                      2235


<210> 26
<211> 2235
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      parent sequence

<400> 26
atgatcaaat caattcagct taaggtgaag ggcgagtgtc ccattactaa agacgtcatt       60

aacgaataca aggagtatta caataactgt agcgactgga tcaagaacaa tttgacatct      120

atcacaattg gggagatggc caaatttttg cagagcctta gcgacaaaga ggtcgcctac      180

atctctatgg ggctctccga cgagtggaag gacaagccgt tgtaccacct gttcacaaaa      240

aagtatcaca caaagaatgc agacaatttg ctgtactact acattaagga gaaaaacctt      300

gatggctata aaggaaacac cctcaacatc tctaacacct cttttagaca gttcggctac      360

tttaagctgg tggtgagcaa ctatagaacc aagattagga ctctgaattg taagatcaaa      420

aggaagaaaa tcgacgctga ttctacctct gaagatattg agatgcaagt catgtatgag      480

atcatcaagt attcactgaa caagaagagt gattgggaca actttatttc ctacatagag      540

aacgtggaga atcccaatat cgataatata aaccgatata agttgctgcg ggagtgcttt      600

tgtgaaaatg agaacatgat taaaaacaag ttggaactct tgtcagtaga acagcttaaa      660

aagttcggcg gctgcatcat gaagcctcat atcaacagca tgacaattaa tatccaagat      720

tttaagatcg aggagaagga aaacagtttg gggtttattt tgcaccttcc actcaataag      780

aaacagtacc agatcgagct tctggggaat cggcagatta agaaagggac caaagagata      840

catgaaactc tggttgatat cacaaatacc catggcgaaa atattgtctt taccatcaag      900

aatgacaacc tgtatatcgt gttttcttat gagtccgaat tcgagaagga agaggtgaac      960

tttgccaaga cagtggggtt ggatgtcaat tttaagcatg ccttctttgt tacctctgaa     1020

aaagataact gccatctgga tggatacatc aatctctata agtatctgct tgagcacgat     1080

gagttcacaa atctgctgac cgaggacgag agaaaggact acgaagaatt gtccaaggtg     1140

gttactttct gcccattcga aaatcagctg ctgttcgcaa gatacaacaa aatgtctaaa     1200

ttctgtaaaa aagagcaggt cctgtctaaa cttctgtatg ctctgcagaa aaaactcaaa     1260

gacgaaaacc gcacaaaaga gtacatttac gtaagctgcg tcaataaatt gagggccaag     1320

tatgtttctt atttcatcct taaagagaaa tactacgaga agcagaagga gtacgacata     1380

gagatggggt ttgtagacga ttctacggag tctaaggaat ctatggacaa acggcgcaca     1440

gagtacccct ttaggaatac ccctgtcgct aatgagttgc tctctaagct gaacaatgtc     1500

caacaggata ttaatggctg cttgaagaac ataataaatt atatttataa aatctttgag     1560

cagaacggct acaaagttgt tgctctggag aaccttgaga acagcaactt tgaaaagaag     1620

caggtactgc ctactattaa gtctctgctg aaatatcata agctggaaaa ccaaaatgtc     1680

aacgacatca aggcctccga caaagtgaaa gagtacatcg agaacggata ctacgagctg     1740

atgactaatg agaataacga gattgtcgac gcgaaatata ccgaaaaggg cgctatgaag     1800

gtgaagaatg ctaatttctt caacttgatg atgaagagcc tccattttgc ttctgtgaag     1860

gatgagtttg tgctgttgag taacaacggg aagacccaga tcgcactggt cccgtccgag     1920

tttacctccc agatggactc tacagatcac tgcttgtaca tgaagaaaaa cgataaaggt     1980

aagttggtga aagcagataa gaaagaggtg cgaacaaagc aggagagaca tatcaacgga     2040

ctgaacgcag attttaacgc tgctaataat attaaatata ttgttgagaa cgaagtgtgg     2100

cggggaattt tctgcaccag accgaaaaaa acagaatata atgtcccgtc cctcgacact     2160

actaaaaaag gcccttctgc gatcctgaac atgcttaaaa agattgaagc gatcaaggtg     2220

ttggagactg agaag                                                      2235


<210> 27
<211> 2235
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      parent sequence

<400> 27
atgatcaaga gcattcagct gaaagtgaag ggcgagtgtc ccatcactaa ggacgttatc       60

aacgagtaca aggagtacta taacaactgc tctgactgga ttaagaataa cctgaccagt      120

atcaccatcg gcgagatggc caagttcctg cagagcctga gcgacaagga ggtggcctac      180

atcagtatgg ggctgtccga tgagtggaaa gacaagccac tgtatcatct gttcaccaaa      240

aagtaccaca ccaaaaatgc cgataacctg ctgtactatt atatcaaaga aaaaaacctg      300

gacgggtaca aaggcaacac cctgaacatc agcaatacaa gtttccgcca gtttggatac      360

ttcaagctgg tcgtgtcaaa ttacagaacc aaaatcagaa ccctgaactg caagatcaaa      420

aggaagaaga tcgacgctga cagcaccagc gaggacattg agatgcaggt gatgtacgag      480

attattaaat actccctgaa caagaagagt gattgggaca atttcatttc ctacatcgag      540

aatgtggaga accctaacat cgataacata aatcggtaca aactgctgag agagtgcttt      600

tgcgagaacg aaaatatgat aaagaacaag ctggagctgc tcagcgtgga acagctgaaa      660

aaatttggag gctgcattat gaagccccac atcaactcaa tgactatcaa tatccaggac      720

ttcaagatcg aagagaagga gaactccctg ggcttcattc tgcatctgcc actgaataag      780

aagcagtatc agatcgaact gctgggaaat aggcagatca agaaggggac caaagagatc      840

cacgaaactc tggtggacat tactaatact cacggggaga acattgtgtt caccattaag      900

aacgataatc tgtacatcgt gttcagctat gaaagcgagt ttgagaagga agaggtgaac      960

ttcgccaaga ccgtcgggct ggatgtgaat tttaagcacg ccttctttgt gaccagcgaa     1020

aaggataact gccacctgga cggatacatc aatctgtaca agtatctgct ggagcacgac     1080

gaatttacca atctgctgac cgaggacgag aggaaggact acgaagagct ctccaaggtg     1140

gtgacatttt gtccattcga gaaccagctg ctgttcgcca gatacaacaa gatgtctaaa     1200

ttttgcaaaa aagaacaggt cctgagcaag ctgctgtacg ccctgcagaa gaaactgaag     1260

gacgagaaca gaactaagga gtacatctat gtgagctgtg tgaataaact gagagcaaaa     1320

tacgtgtctt actttattct gaaggagaag tattacgaga agcagaagga atacgacatc     1380

gagatgggct tcgtggacga ttccacagag agcaaggaaa gcatggataa aaggcgcact     1440

gaatacccct tcagaaacac acctgtggcc aatgagctgc tgtccaagct gaacaacgtg     1500

cagcaggaca tcaacggctg cctgaagaac atcatcaact acatttataa gatcttcgag     1560

cagaatggct acaaagtggt ggcactggag aacctggaga actccaattt tgaaaagaaa     1620

caggtgctgc ccaccattaa gagcctgctt aaataccata agctggagaa ccagaacgtg     1680

aatgatatca aagccagcga taaggtcaaa gagtacatcg agaacggata ttatgagctg     1740

atgaccaacg agaacaatga gatcgtggac gccaaatata ccgagaaggg cgccatgaag     1800

gtgaagaacg ccaacttctt taacctgatg atgaagtccc ttcactttgc ctccgtgaag     1860

gatgagttcg tgctgctgag caacaacggc aagacccaga tcgccctggt gccctctgaa     1920

ttcaccagcc agatggattc aaccgaccac tgtctctaca tgaagaagaa cgacaagggc     1980

aagctggtga aggccgacaa gaaagaggtg cgcacaaagc aggagcggca catcaatggc     2040

ctgaacgctg atttcaacgc cgcaaacaac attaagtaca tcgtggagaa tgaggtgtgg     2100

agaggtattt tctgcacccg ccccaagaag accgagtata atgtgccctc tctggacacc     2160

accaaaaaag gcccaagcgc tatcctgaat atgttgaaga aaatcgaggc catcaaggtg     2220

ctggaaaccg agaag                                                      2235


<210> 28
<211> 56
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 28
cuuguuguau auguccuuuu auagguauua aacaacugag aauggugcgu ccuagg           56


