                         SEQUENCE LISTING

<110>  Conagen Inc.
 
<120>  BIOSYNTHETIC PRODUCTION OF MACROCYCLIC MUSK LACTONES FROM FATTY 
       ACIDS

<130>  C1497.70047WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 63/182,242
<151>  2021-04-30

<150>  US 63/158,843
<151>  2021-03-09

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  1049
<212>  PRT
<213>  Bacillus megaterium

<400>  1

Met Thr Ile Lys Glu Met Pro Gln Pro Lys Thr Phe Gly Glu Leu Lys 
1               5                   10                  15      


Asn Leu Pro Leu Leu Asn Thr Asp Lys Pro Val Gln Ala Leu Met Lys 
            20                  25                  30          


Ile Ala Asp Glu Leu Gly Glu Ile Phe Lys Phe Glu Ala Pro Gly Arg 
        35                  40                  45              


Val Thr Arg Tyr Leu Ser Ser Gln Arg Leu Ile Lys Glu Ala Cys Asp 
    50                  55                  60                  


Glu Ser Arg Phe Asp Lys Asn Leu Ser Gln Ala Leu Lys Phe Val Arg 
65                  70                  75                  80  


Asp Phe Ala Gly Asp Gly Leu Phe Thr Ser Trp Thr His Glu Lys Asn 
                85                  90                  95      


Trp Lys Lys Ala His Asn Ile Leu Leu Pro Ser Phe Ser Gln Gln Ala 
            100                 105                 110         


Met Lys Gly Tyr His Ala Met Met Val Asp Ile Ala Val Gln Leu Val 
        115                 120                 125             


Gln Lys Trp Glu Arg Leu Asn Ala Asp Glu His Ile Glu Val Pro Glu 
    130                 135                 140                 


Asp Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn 
145                 150                 155                 160 


Tyr Arg Phe Asn Ser Phe Tyr Arg Asp Gln Pro His Pro Phe Ile Thr 
                165                 170                 175     


Ser Met Val Arg Ala Leu Asp Glu Ala Met Asn Lys Leu Gln Arg Ala 
            180                 185                 190         


Asn Pro Asp Asp Pro Ala Tyr Asp Glu Asn Lys Arg Gln Phe Gln Glu 
        195                 200                 205             


Asp Ile Lys Val Met Asn Asp Leu Val Asp Lys Ile Ile Ala Asp Arg 
    210                 215                 220                 


Lys Ala Ser Gly Glu Gln Ser Asp Asp Leu Leu Thr His Met Leu Asn 
225                 230                 235                 240 


Gly Lys Asp Pro Glu Thr Gly Glu Pro Leu Asp Asp Glu Asn Ile Arg 
                245                 250                 255     


Tyr Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser Gly 
            260                 265                 270         


Leu Leu Ser Phe Ala Leu Tyr Phe Leu Val Lys Asn Pro His Val Leu 
        275                 280                 285             


Gln Lys Ala Ala Glu Glu Ala Ala Arg Val Leu Val Asp Pro Val Pro 
    290                 295                 300                 


Ser Tyr Lys Gln Val Lys Gln Leu Lys Tyr Val Gly Met Val Leu Asn 
305                 310                 315                 320 


Glu Ala Leu Arg Leu Trp Pro Thr Ala Pro Ala Phe Ser Leu Tyr Ala 
                325                 330                 335     


Lys Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Leu Glu Lys Gly Asp 
            340                 345                 350         


Glu Leu Met Val Leu Ile Pro Gln Leu His Arg Asp Lys Thr Ile Trp 
        355                 360                 365             


Gly Asp Asp Val Glu Glu Phe Arg Pro Glu Arg Phe Glu Asn Pro Ser 
    370                 375                 380                 


Ala Ile Pro Gln His Ala Phe Lys Pro Phe Gly Asn Gly Gln Arg Ala 
385                 390                 395                 400 


Cys Ile Gly Gln Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu Gly 
                405                 410                 415     


Met Met Leu Lys His Phe Asp Phe Glu Asp His Thr Asn Tyr Glu Leu 
            420                 425                 430         


Asp Ile Lys Glu Thr Leu Thr Leu Lys Pro Glu Gly Phe Val Val Lys 
        435                 440                 445             


Ala Lys Ser Lys Lys Ile Pro Leu Gly Gly Ile Pro Ser Pro Ser Thr 
    450                 455                 460                 


Glu Gln Ser Ala Lys Lys Val Arg Lys Lys Ala Glu Asn Ala His Asn 
465                 470                 475                 480 


Thr Pro Leu Leu Val Leu Tyr Gly Ser Asn Met Gly Thr Ala Glu Gly 
                485                 490                 495     


Thr Ala Arg Asp Leu Ala Asp Ile Ala Met Ser Lys Gly Phe Ala Pro 
            500                 505                 510         


Gln Val Ala Thr Leu Asp Ser His Ala Gly Asn Leu Pro Arg Glu Gly 
        515                 520                 525             


Ala Val Leu Ile Val Thr Ala Ser Tyr Asn Gly His Pro Pro Asp Asn 
    530                 535                 540                 


Ala Lys Gln Phe Val Asp Trp Leu Asp Gln Ala Ser Ala Asp Glu Val 
545                 550                 555                 560 


Lys Gly Val Arg Tyr Ser Val Phe Gly Cys Gly Asp Lys Asn Trp Ala 
                565                 570                 575     


Thr Thr Tyr Gln Lys Val Pro Ala Phe Ile Asp Glu Thr Leu Ala Ala 
            580                 585                 590         


Lys Gly Ala Glu Asn Ile Ala Asp Arg Gly Glu Ala Asp Ala Ser Asp 
        595                 600                 605             


Asp Phe Glu Gly Thr Tyr Glu Glu Trp Arg Glu His Met Trp Ser Asp 
    610                 615                 620                 


Val Ala Ala Tyr Phe Asn Leu Asp Ile Glu Asn Ser Glu Asp Asn Lys 
625                 630                 635                 640 


Ser Thr Leu Ser Leu Gln Phe Val Asp Ser Ala Ala Asp Met Pro Leu 
                645                 650                 655     


Ala Lys Met His Gly Ala Phe Ser Thr Asn Val Val Ala Ser Lys Glu 
            660                 665                 670         


Leu Gln Gln Pro Gly Ser Ala Arg Ser Thr Arg His Leu Glu Ile Glu 
        675                 680                 685             


Leu Pro Lys Glu Ala Ser Tyr Gln Glu Gly Asp His Leu Gly Val Ile 
    690                 695                 700                 


Pro Arg Asn Tyr Glu Gly Ile Val Asn Arg Val Thr Ala Arg Phe Gly 
705                 710                 715                 720 


Leu Asp Ala Ser Gln Gln Ile Arg Leu Glu Ala Glu Glu Glu Lys Leu 
                725                 730                 735     


Ala His Leu Pro Leu Ala Lys Thr Val Ser Val Glu Glu Leu Leu Gln 
            740                 745                 750         


Tyr Val Glu Leu Gln Asp Pro Val Thr Arg Thr Gln Leu Arg Ala Met 
        755                 760                 765             


Ala Ala Lys Thr Val Cys Pro Pro His Lys Val Glu Leu Glu Ala Leu 
    770                 775                 780                 


Leu Glu Lys Gln Ala Tyr Lys Glu Gln Val Leu Ala Lys Arg Leu Thr 
785                 790                 795                 800 


Met Leu Glu Leu Leu Glu Lys Tyr Pro Ala Cys Glu Met Lys Phe Ser 
                805                 810                 815     


Glu Phe Ile Ala Leu Leu Pro Ser Ile Arg Pro Arg Tyr Tyr Ser Ile 
            820                 825                 830         


Ser Ser Ser Pro Arg Val Asp Glu Lys Gln Ala Ser Ile Thr Val Ser 
        835                 840                 845             


Val Val Ser Gly Glu Ala Trp Ser Gly Tyr Gly Glu Tyr Lys Gly Ile 
    850                 855                 860                 


Ala Ser Asn Tyr Leu Ala Glu Leu Gln Glu Gly Asp Thr Ile Thr Cys 
865                 870                 875                 880 


Phe Ile Ser Thr Pro Gln Ser Glu Phe Thr Leu Pro Lys Asp Pro Glu 
                885                 890                 895     


Thr Pro Leu Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg 
            900                 905                 910         


Gly Phe Val Gln Ala Arg Lys Gln Leu Lys Glu Gln Gly Gln Ser Leu 
        915                 920                 925             


Gly Glu Ala His Leu Tyr Phe Gly Cys Arg Ser Pro His Glu Asp Tyr 
    930                 935                 940                 


Leu Tyr Gln Glu Glu Leu Glu Asn Ala Gln Ser Glu Gly Ile Ile Thr 
945                 950                 955                 960 


Leu His Thr Ala Phe Ser Arg Met Pro Asn Gln Pro Lys Thr Tyr Val 
                965                 970                 975     


Gln His Val Met Glu Gln Asp Gly Lys Lys Leu Ile Glu Leu Leu Asp 
            980                 985                 990         


Gln Gly Ala His Phe Tyr Ile Cys  Gly Asp Gly Ser Gln  Met Ala Pro 
        995                 1000                 1005             


Ala Val  Glu Ala Thr Leu Met  Lys Ser Tyr Ala Asp  Val His Gln 
    1010                 1015                 1020             


Val Ser  Glu Ala Asp Ala Arg  Leu Trp Leu Gln Gln  Leu Glu Glu 
    1025                 1030                 1035             


Lys Gly  Arg Tyr Ala Lys Asp  Val Trp Ala Gly 
    1040                 1045                 


<210>  2
<211>  3150
<212>  DNA
<213>  Bacillus megaterium

<400>  2
atgacaatta aagaaatgcc tcagccaaaa acgtttggag agcttaaaaa tttaccgtta       60

ttaaacacag ataaaccggt tcaagctttg atgaaaattg cggatgaatt aggagaaatc      120

tttaaattcg aggcgcctgg tcgtgtaacg cgctacttat caagtcagcg tctaattaaa      180

gaagcatgcg atgaatcacg ctttgataaa aacttaagtc aagcgcttaa atttgtacgt      240

gattttgcag gagacgggtt atttacaagc tggacgcatg aaaaaaattg gaaaaaagcg      300

cataatatct tacttccaag cttcagtcag caggcaatga aaggctatca tgcgatgatg      360

gtcgatatcg ccgtgcagct tgttcaaaag tgggagcgtc taaatgcaga tgagcatatt      420

gaagtaccgg aagacatgac acgtttaacg cttgatacaa ttggtctttg cggctttaac      480

tatcgcttta acagctttta ccgagatcag cctcatccat ttattacaag tatggtccgt      540

gcactggatg aagcaatgaa caagctgcag cgagcaaatc cagacgaccc agcttatgat      600

gaaaacaagc gccagtttca agaagatatc aaggtgatga acgacctagt agataaaatt      660

attgcagatc gcaaagcaag cggtgaacaa agcgatgatt tattaacgca tatgctaaac      720

ggaaaagatc cagaaacggg tgagccgctt gatgacgaga acattcgcta tcaaattatt      780

acattcttaa ttgcgggaca cgaaacaaca agtggtcttt tatcatttgc gctgtatttc      840

ttagtgaaaa atccacatgt attacaaaaa gcagcagaag aagcagcacg agttctagta      900

gatcctgttc caagctacaa acaagtcaaa cagcttaaat atgtcggcat ggtcttaaac      960

gaagcgctgc gcttatggcc aactgctcct gcgttttccc tatatgcaaa agaagatacg     1020

gtgcttggag gagaatatcc tttagaaaaa ggcgacgaac taatggttct gattcctcag     1080

cttcaccgtg ataaaacaat ttggggagac gatgtggaag agttccgtcc agagcgtttt     1140

gaaaatccaa gtgcgattcc gcagcatgcg tttaaaccgt ttggaaacgg tcagcgtgcg     1200

tgtatcggtc agcagttcgc tcttcatgaa gcaacgctgg tacttggtat gatgctaaaa     1260

cactttgact ttgaagatca tacaaactac gagctggata ttaaagaaac tttaacgtta     1320

aaacctgaag gctttgtggt aaaagcaaaa tcgaaaaaaa ttccgcttgg cggtattcct     1380

tcacctagca ctgaacagtc tgctaaaaaa gtacgcaaaa aggcagaaaa cgctcataat     1440

acgccgctgc ttgtgctata cggttcaaat atgggaacag ctgaaggaac ggcgcgtgat     1500

ttagcagata ttgcaatgag caaaggattt gcaccgcagg tcgcaacgct tgattcacac     1560

gccggaaatc ttccgcgcga aggagctgta ttaattgtaa cggcgtctta taacggtcat     1620

ccgcctgata acgcaaagca atttgtcgac tggttagacc aagcgtctgc tgatgaagta     1680

aaaggcgttc gctactccgt atttggatgc ggcgataaaa actgggctac tacgtatcaa     1740

aaagtgcctg cttttatcga tgaaacgctt gccgctaaag gggcagaaaa catcgctgac     1800

cgcggtgaag cagatgcaag cgacgacttt gaaggcacat atgaagaatg gcgtgaacat     1860

atgtggagtg acgtagcagc ctactttaac ctcgacattg aaaacagtga agataataaa     1920

tctactcttt cacttcaatt tgtcgacagc gccgcggata tgccgcttgc gaaaatgcac     1980

ggtgcgtttt caacgaacgt cgtagcaagc aaagaacttc aacagccagg cagtgcacga     2040

agcacgcgac atcttgaaat tgaacttcca aaagaagctt cttatcaaga aggagatcat     2100

ttaggtgtta ttcctcgcaa ctatgaagga atagtaaacc gtgtaacagc aaggttcggc     2160

ctagatgcat cacagcaaat ccgtctggaa gcagaagaag aaaaattagc tcatttgcca     2220

ctcgctaaaa cagtatccgt agaagagctt ctgcaatacg tggagcttca agatcctgtt     2280

acgcgcacgc agcttcgcgc aatggctgct aaaacggtct gcccgccgca taaagtagag     2340

cttgaagcct tgcttgaaaa gcaagcctac aaagaacaag tgctggcaaa acgtttaaca     2400

atgcttgaac tgcttgaaaa atacccggcg tgtgaaatga aattcagcga atttatcgcc     2460

cttctgccaa gcatacgccc gcgctattac tcgatttctt catcacctcg tgtcgatgaa     2520

aaacaagcaa gcatcacggt cagcgttgtc tcaggagaag cgtggagcgg atatggagaa     2580

tataaaggaa ttgcgtcgaa ctatcttgcc gagctgcaag aaggagatac gattacgtgc     2640

tttatttcca caccgcagtc agaatttacg ctgccaaaag accctgaaac gccgcttatc     2700

atggtcggac cgggaacagg cgtcgcgccg tttagaggct ttgtgcaggc gcgcaaacag     2760

ctaaaagaac aaggacagtc acttggagaa gcacatttat acttcggctg ccgttcacct     2820

catgaagact atctgtatca agaagagctt gaaaacgccc aaagcgaagg catcattacg     2880

cttcataccg ctttttctcg catgccaaat cagccgaaaa catacgttca gcacgtaatg     2940

gaacaagacg gcaagaaatt gattgaactt cttgatcaag gagcgcactt ctatatttgc     3000

ggagacggaa gccaaatggc acctgccgtt gaagcaacgc ttatgaaaag ctatgctgac     3060

gttcaccaag tgagtgaagc agacgctcgc ttatggctgc agcagctaga agaaaaaggc     3120

cgatacgcaa aagacgtgtg ggctgggtaa                                      3150


<210>  3
<211>  1080
<212>  PRT
<213>  Myceliophthora thermophila

<400>  3

Met Ala Asp Lys Thr Thr Glu Thr Val Pro Ile Pro Gly Pro Pro Gly 
1               5                   10                  15      


Leu Pro Leu Val Gly Asn Ala Leu Ala Phe Asp Ser Glu Leu Pro Leu 
            20                  25                  30          


Arg Thr Phe Gln Glu Phe Ala Glu Glu Tyr Gly Glu Ile Tyr Arg Leu 
        35                  40                  45              


Thr Leu Pro Thr Gly Thr Thr Leu Val Val Ser Ser Gln Ala Leu Val 
    50                  55                  60                  


His Glu Leu Cys Asp Asp Lys Arg Phe Lys Lys Pro Val Ala Ala Ala 
65                  70                  75                  80  


Leu Ala Glu Val Arg Asn Gly Val Asn Asp Gly Leu Phe Thr Ala Arg 
                85                  90                  95      


Glu Glu Glu Pro Asn Trp Gly Ile Ala His Arg Ile Leu Met Pro Ala 
            100                 105                 110         


Phe Gly Pro Ala Ser Ile Gln Gly Met Phe Thr Glu Met His Glu Ile 
        115                 120                 125             


Ala Ser Gln Leu Ala Leu Lys Trp Ala Arg His Gly Pro Asp Thr Pro 
    130                 135                 140                 


Ile Phe Val Thr Asp Asp Phe Thr Arg Leu Thr Leu Asp Thr Leu Ala 
145                 150                 155                 160 


Leu Cys Thr Met Asn Phe Arg Phe Asn Ser Tyr Tyr His Asp Glu Leu 
                165                 170                 175     


His Pro Phe Ile Asn Ala Met Gly Asn Phe Leu Thr Glu Ser Gly Ala 
            180                 185                 190         


Arg Ala Met Arg Pro Ala Ile Thr Ser Ile Phe His Gln Ala Ala Asn 
        195                 200                 205             


Arg Lys Tyr Trp Glu Asp Ile Glu Val Leu Arg Lys Thr Ala Gln Gly 
    210                 215                 220                 


Val Leu Asp Thr Arg Arg Lys His Pro Thr Asn Arg Lys Asp Leu Leu 
225                 230                 235                 240 


Ser Ala Met Leu Asp Gly Val Asp Ala Lys Thr Gly Gln Lys Leu Ser 
                245                 250                 255     


Asp Ser Ser Ile Ile Asp Asn Leu Ile Thr Phe Leu Ile Ala Gly His 
            260                 265                 270         


Glu Thr Thr Ser Gly Leu Leu Ser Phe Ala Phe Tyr Leu Leu Ile Lys 
        275                 280                 285             


His Gln Asp Ala Tyr Arg Lys Ala Gln Glu Glu Val Asp Arg Val Ile 
    290                 295                 300                 


Gly Lys Gly Pro Ile Lys Val Glu His Ile Lys Lys Leu Pro Tyr Ile 
305                 310                 315                 320 


Ala Ala Val Leu Arg Glu Thr Leu Arg Leu Cys Pro Thr Ile Pro Ile 
                325                 330                 335     


Ile Asn Arg Ala Ala Lys Gln Asp Glu Val Ile Gly Gly Lys Tyr Ala 
            340                 345                 350         


Val Ala Lys Asp Gln Arg Leu Ala Leu Leu Leu Ala Gln Ser His Leu 
        355                 360                 365             


Asp Pro Ala Val Tyr Gly Glu Thr Ala Lys Gln Phe Ile Pro Glu Arg 
    370                 375                 380                 


Met Leu Asp Glu Asn Phe Glu Arg Leu Asn Arg Glu Tyr Pro Asp Cys 
385                 390                 395                 400 


Trp Lys Pro Phe Gly Thr Gly Met Arg Ala Cys Ile Gly Arg Pro Phe 
                405                 410                 415     


Ala Trp Gln Glu Ala Val Leu Val Met Ala Met Leu Leu Gln Asn Phe 
            420                 425                 430         


Asp Phe Val Leu His Asp Pro Tyr Tyr Glu Leu His Tyr Lys Gln Thr 
        435                 440                 445             


Leu Thr Thr Lys Pro Lys Asp Phe Tyr Met Arg Ala Ile Leu Arg Asp 
    450                 455                 460                 


Gly Leu Thr Ala Thr Glu Leu Glu His Arg Leu Ala Gly Asn Ala Ala 
465                 470                 475                 480 


Ser Val Ala Arg Ser Gly Gly Gly Gly Gly Gly Pro Ser Lys Pro Thr 
                485                 490                 495     


Ala Gln Lys Thr Ser Pro Ala Glu Ala Lys Pro Met Ser Ile Phe Tyr 
            500                 505                 510         


Gly Ser Asn Thr Gly Thr Cys Glu Ser Leu Ala Gln Arg Leu Ala Thr 
        515                 520                 525             


Asp Ala Ala Ser His Gly Tyr Ala Ala Ala Ala Val Glu Pro Leu Asp 
    530                 535                 540                 


Thr Ala Thr Glu Lys Leu Pro Thr Asp Arg Pro Val Val Ile Ile Thr 
545                 550                 555                 560 


Ala Ser Phe Glu Gly Gln Pro Pro Asp Asn Ala Ala Lys Phe Cys Gly 
                565                 570                 575     


Trp Leu Lys Asn Leu Glu Gly Asp Glu Leu Lys Asn Val Ser Tyr Ala 
            580                 585                 590         


Val Phe Gly Cys Gly His His Asp Trp Ser Gln Thr Phe His Arg Ile 
        595                 600                 605             


Pro Lys Leu Val His Gln Thr Met Lys Ala His Gly Ala Ser Pro Ile 
    610                 615                 620                 


Cys Asp Glu Gly Leu Thr Asp Val Ala Glu Gly Asn Met Phe Thr Asp 
625                 630                 635                 640 


Phe Glu Gln Trp Glu Asp Asp Val Phe Trp Pro Ala Val Arg Ala Arg 
                645                 650                 655     


Tyr Gly Ala Ala Gly Ala Val Ala Glu Thr Glu Asp Ala Pro Gly Ser 
            660                 665                 670         


Asp Gly Leu Asn Ile His Phe Ser Ser Pro Arg Ser Ser Thr Leu Arg 
        675                 680                 685             


Gln Asp Val Arg Glu Ala Thr Val Val Gly Glu Ala Leu Leu Thr Ala 
    690                 695                 700                 


Pro Asp Ala Pro Pro Lys Lys His Ile Glu Val Gln Leu Pro Asp Gly 
705                 710                 715                 720 


Ala Thr Tyr Lys Val Gly Asp Tyr Leu Ala Val Leu Pro Val Asn Ser 
                725                 730                 735     


Lys Glu Ser Ile Gly Arg Val Met Arg Lys Phe Gln Leu Ser Trp Asp 
            740                 745                 750         


Ser His Val Thr Ile Ala Ser Asp Arg Trp Thr Ala Leu Pro Thr Gly 
        755                 760                 765             


Thr Pro Val Pro Ala Tyr Asp Val Leu Gly Ser Tyr Val Glu Leu Ser 
    770                 775                 780                 


Gln Pro Ala Thr Lys Arg Gly Ile Leu Arg Leu Ala Asp Ala Ala Glu 
785                 790                 795                 800 


Asp Glu Ala Thr Lys Ala Glu Leu Gln Lys Leu Ala Gly Asp Leu Tyr 
                805                 810                 815     


Thr Ser Glu Ile Ser Leu Lys Arg Ala Ser Val Leu Asp Leu Leu Asp 
            820                 825                 830         


Arg Phe Pro Ser Ile Ser Leu Pro Phe Gly Thr Phe Leu Ser Leu Leu 
        835                 840                 845             


Pro Pro Ile Arg Pro Arg Gln Tyr Ser Ile Ser Ser Ser Pro Leu Asn 
    850                 855                 860                 


Asp Pro Ser Arg Ala Thr Leu Thr Tyr Ser Leu Leu Asp Ser Pro Ser 
865                 870                 875                 880 


Leu Ala Asn Pro Ser Arg Arg Phe Val Gly Val Ala Thr Ser Tyr Leu 
                885                 890                 895     


Ser Ser Leu Val Arg Gly Asp Lys Leu Leu Val Ser Val Arg Pro Thr 
            900                 905                 910         


His Thr Ala Phe Arg Leu Pro Asp Glu Asp Lys Met Gly Glu Thr Ala 
        915                 920                 925             


Ile Ile Cys Val Gly Ala Gly Ser Gly Leu Ala Pro Phe Arg Gly Phe 
    930                 935                 940                 


Ile Gln Glu Arg Ala Ala Leu Leu Ala Lys Gly Thr Gln Leu Ala Ala 
945                 950                 955                 960 


Ala Leu Leu Phe Tyr Gly Cys Arg Ser Pro Glu Lys Asp Asp Leu Tyr 
                965                 970                 975     


Arg Asp Glu Phe Asp Lys Trp Gln Glu Ser Gly Ala Val Asp Val Arg 
            980                 985                 990         


Arg Ala Phe Ser Arg Val Asp Ser  Asp Asp Thr Glu Ala  Arg Gly Cys 
        995                 1000                 1005             


Arg His  Val Gln Asp Arg Leu  Trp His Asp Arg Glu  Glu Val Lys 
    1010                 1015                 1020             


Ala Leu  Trp Asp Arg Gly Ala  Arg Val Tyr Val Cys  Gly Ser Arg 
    1025                 1030                 1035             


Gln Val  Gly Glu Gly Val Lys  Thr Ala Met Gly Arg  Ile Val Leu 
    1040                 1045                 1050             


Gly Glu  Glu Asp Ala Glu Asp  Ala Ile Ser Lys Trp  Tyr Glu Thr 
    1055                 1060                 1065             


Val Arg  Asn Asp Arg Tyr Ala  Thr Asp Val Phe Asp  
    1070                 1075                 1080 


<210>  4
<211>  3243
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4
atggcggata agaccaccga aaccgtgccg attccgggtc cgccgggcct gccgctggtt       60

ggtaatgcgc tggcgtttga tagcgaactg ccgctgcgta ccttccagga atttgcggag      120

gaatacggcg agatctatcg tctgaccctg ccgaccggta ccaccctggt ggttagcagc      180

caagcgctgg ttcacgaact gtgcgacgat aagcgtttca agaagccggt tgctgcggcg      240

ctggcggaag tgcgtaacgg cgttaacgac ggtctgttta ccgcgcgtga agaggagccg      300

aactggggca tcgcgcaccg tattctgatg ccggcgtttg gtccggcgag cattcagggc      360

atgtttaccg aaatgcacga gatcgcgagc caactggcgc tgaaatgggc gcgtcacggt      420

ccggacaccc cgattttcgt taccgacgat tttacccgtc tgaccctgga taccctggcg      480

ctgtgcacca tgaacttccg ttttaacagc tactatcacg acgaactgca cccgttcatc      540

aacgcgatgg gcaactttct gaccgagagc ggtgcgcgtg cgatgcgtcc ggcgatcacc      600

agcattttcc accaggcggc gaaccgtaag tactgggaag atattgaggt tctgcgtaaa      660

accgcgcaag gtgtgctgga cacccgtcgt aagcacccga ccaaccgtaa agatctgctg      720

agcgcgatgc tggacggcgt ggatgcgaaa accggtcaga aactgagcga cagcagcatc      780

attgataacc tgatcacctt tctgattgcg ggccacgaaa ccaccagcgg tctgctgagc      840

ttcgcgtttt acctgctgat taagcaccag gacgcgtatc gtaaagcgca agaagaggtg      900

gatcgtgtta tcggcaaggg cccgattaaa gttgaacaca tcaagaaact gccgtacatc      960

gcggcggtgc tgcgtgaaac cctgcgtctg tgcccgacca ttccgatcat taaccgtgcg     1020

gcgaagcagg acgaagttat cggtggcaag tacgcggtgg cgaaagatca gcgtctggcg     1080

ctgctgctgg cgcaaagcca cctggacccg gcggtttatg gcgaaaccgc gaagcaattc     1140

attccggagc gtatgctgga cgaaaacttt gagcgtctga accgtgagta tccggattgc     1200

tggaaaccgt tcggtaccgg catgcgtgcg tgcatcggtc gtccgtttgc gtggcaggaa     1260

gcggtgctgg ttatggcgat gctgctgcaa aacttcgact ttgttctgca cgatccgtac     1320

tatgagctgc actacaagca gaccctgacc accaagccga aagacttcta tatgcgtgcg     1380

atcctgcgtg atggcctgac cgcgaccgaa ctggagcacc gtctggcggg taacgcggcg     1440

agcgtggcgc gtagcggtgg cggtggcggt ggcccgagca aaccgaccgc gcagaaaacc     1500

agcccggcgg aagcgaaacc gatgagcatc ttctacggca gcaacaccgg tacctgcgag     1560

agcctggcgc aacgtctggc gaccgatgcg gcgagccacg gttatgctgc ggcggcggtg     1620

gaaccgctgg acaccgcgac cgagaagctg ccgaccgatc gtccggtggt tatcattacc     1680

gcgagcttcg agggtcagcc gccggacaac gcggcgaagt tttgcggctg gctgaaaaac     1740

ctggaaggtg atgagctgaa aaacgtgagc tacgcggttt tcggttgcgg ccaccacgac     1800

tggagccaga cctttcaccg tattccgaag ctggttcacc aaaccatgaa agcgcacggt     1860

gcgagcccga tctgcgacga aggcctgacc gatgtggcgg agggtaacat gttcaccgat     1920

tttgaacaat gggaggacga tgtgttctgg ccggcggttc gtgcgcgtta tggcgcggcg     1980

ggtgcggttg cggaaaccga ggacgcgccg ggtagcgatg gtctgaacat ccactttagc     2040

agcccgcgta gcagcaccct gcgtcaggac gtgcgtgaag cgaccgtggt tggtgaagcg     2100

ctgctgaccg cgccggatgc gccgccgaag aaacacattg aagttcaact gccggacggc     2160

gcgacctaca aagtgggtga ttatctggcg gtgctgccgg ttaacagcaa ggagagcatt     2220

ggtcgtgtta tgcgtaaatt ccagctgagc tgggacagcc acgtgaccat cgcgagcgat     2280

cgttggaccg cgctgccgac cggtaccccg gtgccggcgt acgacgttct gggtagctat     2340

gtggagctga gccaaccggc gaccaaacgt ggtatcctgc gtctggcgga tgcggcggaa     2400

gatgaggcga ccaaggcgga actgcaaaaa ctggcgggtg atctgtacac cagcgagatt     2460

agcctgaaac gtgcgagcgt tctggacctg ctggatcgtt tcccgagcat cagcctgccg     2520

ttcggtacct ttctgagcct gctgccgccg attcgtccgc gtcaatacag catcagcagc     2580

agcccgctga acgacccgag ccgtgcgacc ctgacctata gcctgctgga tagcccgagc     2640

ctggcgaacc cgagccgtcg tttcgtgggc gttgcgacca gctacctgag cagcctggtt     2700

cgtggtgaca agctgctggt gagcgttcgt ccgacccaca ccgcgtttcg tctgccggac     2760

gaagataaaa tgggtgaaac cgcgatcatt tgcgtgggtg cgggtagcgg tctggcgccg     2820

ttccgtggtt ttatccagga acgtgcggcg ctgctggcga aaggtaccca actggcggcg     2880

gcgctgctgt tctacggttg ccgtagcccg gagaaggacg atctgtatcg tgacgaattc     2940

gataaatggc aagagagcgg tgcggtggat gttcgtcgtg cgtttagccg tgttgatagc     3000

gacgataccg aggcgcgtgg ttgccgtcac gttcaggacc gtctgtggca cgatcgtgaa     3060

gaggtgaagg cgctgtggga ccgtggcgcg cgtgtgtacg tttgcggtag ccgtcaagtg     3120

ggcgaaggtg ttaaaaccgc gatgggccgt atcgtgctgg gtgaagagga cgcggaggat     3180

gcgatcagca agtggtatga aaccgtgcgt aatgaccgtt atgcgaccga tgtgttcgac     3240

taa                                                                   3243


<210>  5
<211>  342
<212>  PRT
<213>  Candida antarctica

<400>  5

Met Lys Leu Leu Ser Leu Thr Gly Val Ala Gly Val Leu Ala Thr Cys 
1               5                   10                  15      


Val Ala Ala Thr Pro Leu Val Lys Arg Leu Pro Ser Gly Ser Asp Pro 
            20                  25                  30          


Ala Phe Ser Gln Pro Lys Ser Val Leu Asp Ala Gly Leu Thr Cys Gln 
        35                  40                  45              


Gly Ala Ser Pro Ser Ser Val Ser Lys Pro Ile Leu Leu Val Pro Gly 
    50                  55                  60                  


Thr Gly Thr Thr Gly Pro Gln Ser Phe Asp Ser Asn Trp Ile Pro Leu 
65                  70                  75                  80  


Ser Thr Gln Leu Gly Tyr Thr Pro Cys Trp Ile Ser Pro Pro Pro Phe 
                85                  90                  95      


Met Leu Asn Asp Thr Gln Val Asn Thr Glu Tyr Met Val Asn Ala Ile 
            100                 105                 110         


Thr Ala Leu Tyr Ala Gly Ser Gly Asn Asn Lys Leu Pro Val Leu Thr 
        115                 120                 125             


Trp Ser Gln Gly Gly Leu Val Ala Gln Trp Gly Leu Thr Phe Phe Pro 
    130                 135                 140                 


Ser Ile Arg Ser Lys Val Asp Arg Leu Met Ala Phe Ala Pro Asp Tyr 
145                 150                 155                 160 


Lys Gly Thr Val Leu Ala Gly Pro Leu Asp Ala Leu Ala Val Ser Ala 
                165                 170                 175     


Pro Ser Val Trp Gln Gln Thr Thr Gly Ser Ala Leu Thr Thr Ala Leu 
            180                 185                 190         


Arg Asn Ala Gly Gly Leu Thr Gln Ile Val Pro Thr Thr Asn Leu Tyr 
        195                 200                 205             


Ser Ala Thr Asp Glu Ile Val Gln Pro Gln Val Ser Asn Ser Pro Leu 
    210                 215                 220                 


Asp Ser Ser Tyr Leu Phe Asn Gly Lys Asn Val Gln Ala Gln Ala Val 
225                 230                 235                 240 


Cys Gly Pro Leu Phe Val Ile Asp His Ala Gly Ser Leu Thr Ser Gln 
                245                 250                 255     


Phe Ser Tyr Val Val Gly Arg Ser Ala Leu Arg Ser Thr Thr Gly Gln 
            260                 265                 270         


Ala Arg Ser Ala Asp Tyr Gly Ile Thr Asp Cys Asn Pro Leu Pro Ala 
        275                 280                 285             


Asn Asp Leu Thr Pro Glu Gln Lys Val Ala Ala Ala Ala Leu Leu Ala 
    290                 295                 300                 


Pro Ala Ala Ala Ala Ile Val Ala Gly Pro Lys Gln Asn Cys Glu Pro 
305                 310                 315                 320 


Asp Leu Met Pro Tyr Ala Arg Pro Phe Ala Val Gly Lys Arg Thr Cys 
                325                 330                 335     


Ser Gly Ile Val Thr Pro 
            340         


