                         SEQUENCE LISTING

<110>  Ludwig Institute for Cancer Research Ltd
       Centre Hospitalier Universitaire Vaudois
       Universite de Lausanne
 
<120>  ANTI-TEM1 ANTIBODIES AND ANTIGEN-BINDING PORTIONS THEREOF

<130>  084276.00328

<150>  63/158,944
<151>  2021-03-10

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  757
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Leu Arg Leu Leu Leu Ala Trp Ala Ala Ala Gly Pro Thr Leu 
1               5                   10                  15      


Gly Gln Asp Pro Trp Ala Ala Glu Pro Arg Ala Ala Cys Gly Pro Ser 
            20                  25                  30          


Ser Cys Tyr Ala Leu Phe Pro Arg Arg Arg Thr Phe Leu Glu Ala Trp 
        35                  40                  45              


Arg Ala Cys Arg Glu Leu Gly Gly Asp Leu Ala Thr Pro Arg Thr Pro 
    50                  55                  60                  


Glu Glu Ala Gln Arg Val Asp Ser Leu Val Gly Ala Gly Pro Ala Ser 
65                  70                  75                  80  


Arg Leu Leu Trp Ile Gly Leu Gln Arg Gln Ala Arg Gln Cys Gln Leu 
                85                  90                  95      


Gln Arg Pro Leu Arg Gly Phe Thr Trp Thr Thr Gly Asp Gln Asp Thr 
            100                 105                 110         


Ala Phe Thr Asn Trp Ala Gln Pro Ala Ser Gly Gly Pro Cys Pro Ala 
        115                 120                 125             


Gln Arg Cys Val Ala Leu Glu Ala Ser Gly Glu His Arg Trp Leu Glu 
    130                 135                 140                 


Gly Ser Cys Thr Leu Ala Val Asp Gly Tyr Leu Cys Gln Phe Gly Phe 
145                 150                 155                 160 


Glu Gly Ala Cys Pro Ala Leu Gln Asp Glu Ala Gly Gln Ala Gly Pro 
                165                 170                 175     


Ala Val Tyr Thr Thr Pro Phe His Leu Val Ser Thr Glu Phe Glu Trp 
            180                 185                 190         


Leu Pro Phe Gly Ser Val Ala Ala Val Gln Cys Gln Ala Gly Arg Gly 
        195                 200                 205             


Ala Ser Leu Leu Cys Val Lys Gln Pro Glu Gly Gly Val Gly Trp Ser 
    210                 215                 220                 


Arg Ala Gly Pro Leu Cys Leu Gly Thr Gly Cys Ser Pro Asp Asn Gly 
225                 230                 235                 240 


Gly Cys Glu His Glu Cys Val Glu Glu Val Asp Gly His Val Ser Cys 
                245                 250                 255     


Arg Cys Thr Glu Gly Phe Arg Leu Ala Ala Asp Gly Arg Ser Cys Glu 
            260                 265                 270         


Asp Pro Cys Ala Gln Ala Pro Cys Glu Gln Gln Cys Glu Pro Gly Gly 
        275                 280                 285             


Pro Gln Gly Tyr Ser Cys His Cys Arg Leu Gly Phe Arg Pro Ala Glu 
    290                 295                 300                 


Asp Asp Pro His Arg Cys Val Asp Thr Asp Glu Cys Gln Ile Ala Gly 
305                 310                 315                 320 


Val Cys Gln Gln Met Cys Val Asn Tyr Val Gly Gly Phe Glu Cys Tyr 
                325                 330                 335     


Cys Ser Glu Gly His Glu Leu Glu Ala Asp Gly Ile Ser Cys Ser Pro 
            340                 345                 350         


Ala Gly Ala Met Gly Ala Gln Ala Ser Gln Asp Leu Gly Asp Glu Leu 
        355                 360                 365             


Leu Asp Asp Gly Glu Asp Glu Glu Asp Glu Asp Glu Ala Trp Lys Ala 
    370                 375                 380                 


Phe Asn Gly Gly Trp Thr Glu Met Pro Gly Ile Leu Trp Met Glu Pro 
385                 390                 395                 400 


Thr Gln Pro Pro Asp Phe Ala Leu Ala Tyr Arg Pro Ser Phe Pro Glu 
                405                 410                 415     


Asp Arg Glu Pro Gln Ile Pro Tyr Pro Glu Pro Thr Trp Pro Pro Pro 
            420                 425                 430         


Leu Ser Ala Pro Arg Val Pro Tyr His Ser Ser Val Leu Ser Val Thr 
        435                 440                 445             


Arg Pro Val Val Val Ser Ala Thr His Pro Thr Leu Pro Ser Ala His 
    450                 455                 460                 


Gln Pro Pro Val Ile Pro Ala Thr His Pro Ala Leu Ser Arg Asp His 
465                 470                 475                 480 


Gln Ile Pro Val Ile Ala Ala Asn Tyr Pro Asp Leu Pro Ser Ala Tyr 
                485                 490                 495     


Gln Pro Gly Ile Leu Ser Val Ser His Ser Ala Gln Pro Pro Ala His 
            500                 505                 510         


Gln Pro Pro Met Ile Ser Thr Lys Tyr Pro Glu Leu Phe Pro Ala His 
        515                 520                 525             


Gln Ser Pro Met Phe Pro Asp Thr Arg Val Ala Gly Thr Gln Thr Thr 
    530                 535                 540                 


Thr His Leu Pro Gly Ile Pro Pro Asn His Ala Pro Leu Val Thr Thr 
545                 550                 555                 560 


Leu Gly Ala Gln Leu Pro Pro Gln Ala Pro Asp Ala Leu Val Leu Arg 
                565                 570                 575     


Thr Gln Ala Thr Gln Leu Pro Ile Ile Pro Thr Ala Gln Pro Ser Leu 
            580                 585                 590         


Thr Thr Thr Ser Arg Ser Pro Val Ser Pro Ala His Gln Ile Ser Val 
        595                 600                 605             


Pro Ala Ala Thr Gln Pro Ala Ala Leu Pro Thr Leu Leu Pro Ser Gln 
    610                 615                 620                 


Ser Pro Thr Asn Gln Thr Ser Pro Ile Ser Pro Thr His Pro His Ser 
625                 630                 635                 640 


Lys Ala Pro Gln Ile Pro Arg Glu Asp Gly Pro Ser Pro Lys Leu Ala 
                645                 650                 655     


Leu Trp Leu Pro Ser Pro Ala Pro Thr Ala Ala Pro Thr Ala Leu Gly 
            660                 665                 670         


Glu Ala Gly Leu Ala Glu His Ser Gln Arg Asp Asp Arg Trp Leu Leu 
        675                 680                 685             


Val Ala Leu Leu Val Pro Thr Cys Val Phe Leu Val Val Leu Leu Ala 
    690                 695                 700                 


Leu Gly Ile Val Tyr Cys Thr Arg Cys Gly Pro His Ala Pro Asn Lys 
705                 710                 715                 720 


Arg Ile Thr Asp Cys Tyr Arg Trp Val Ile His Ala Gly Ser Lys Ser 
                725                 730                 735     


Pro Thr Glu Pro Met Pro Pro Arg Gly Ser Leu Thr Gly Val Gln Thr 
            740                 745                 750         


Cys Arg Thr Ser Val 
        755         


<210>  2
<211>  765
<212>  PRT
<213>  Mus musculus

<400>  2

Met Leu Leu Arg Leu Leu Leu Ala Trp Val Ala Ala Val Pro Ala Leu 
1               5                   10                  15      


Gly Gln Val Pro Trp Thr Pro Glu Pro Arg Ala Ala Cys Gly Pro Ser 
            20                  25                  30          


Ser Cys Tyr Ala Leu Phe Pro Arg Arg Arg Thr Phe Leu Glu Ala Trp 
        35                  40                  45              


Arg Ala Cys Arg Glu Leu Gly Gly Asn Leu Ala Thr Pro Arg Thr Pro 
    50                  55                  60                  


Glu Glu Ala Gln Arg Val Asp Ser Leu Val Gly Val Gly Pro Ala Asn 
65                  70                  75                  80  


Gly Leu Leu Trp Ile Gly Leu Gln Arg Gln Ala Arg Gln Cys Gln Pro 
                85                  90                  95      


Gln Arg Pro Leu Arg Gly Phe Ile Trp Thr Thr Gly Asp Gln Asp Thr 
            100                 105                 110         


Ala Phe Thr Asn Trp Ala Gln Pro Ala Thr Glu Gly Pro Cys Pro Ala 
        115                 120                 125             


Gln Arg Cys Ala Ala Leu Glu Ala Ser Gly Glu His Arg Trp Leu Glu 
    130                 135                 140                 


Gly Ser Cys Thr Leu Ala Val Asp Gly Tyr Leu Cys Gln Phe Gly Phe 
145                 150                 155                 160 


Glu Gly Ala Cys Pro Ala Leu Pro Leu Glu Val Gly Gln Ala Gly Pro 
                165                 170                 175     


Ala Val Tyr Thr Thr Pro Phe Asn Leu Val Ser Ser Glu Phe Glu Trp 
            180                 185                 190         


Leu Pro Phe Gly Ser Val Ala Ala Val Gln Cys Gln Ala Gly Arg Gly 
        195                 200                 205             


Ala Ser Leu Leu Cys Val Lys Gln Pro Ser Gly Gly Val Gly Trp Ser 
    210                 215                 220                 


Gln Thr Gly Pro Leu Cys Pro Gly Thr Gly Cys Gly Pro Asp Asn Gly 
225                 230                 235                 240 


Gly Cys Glu His Glu Cys Val Glu Glu Val Asp Gly Ala Val Ser Cys 
                245                 250                 255     


Arg Cys Ser Glu Gly Phe Arg Leu Ala Ala Asp Gly His Ser Cys Glu 
            260                 265                 270         


Asp Pro Cys Ala Gln Ala Pro Cys Glu Gln Gln Cys Glu Pro Gly Gly 
        275                 280                 285             


Pro Gln Gly Tyr Ser Cys His Cys Arg Leu Gly Phe Arg Pro Ala Glu 
    290                 295                 300                 


Asp Asp Pro His Arg Cys Val Asp Thr Asp Glu Cys Gln Ile Ala Gly 
305                 310                 315                 320 


Val Cys Gln Gln Met Cys Val Asn Tyr Val Gly Gly Phe Glu Cys Tyr 
                325                 330                 335     


Cys Ser Glu Gly His Glu Leu Glu Ala Asp Gly Ile Ser Cys Ser Pro 
            340                 345                 350         


Ala Gly Ala Met Gly Ala Gln Ala Ser Gln Asp Leu Arg Asp Glu Leu 
        355                 360                 365             


Leu Asp Asp Gly Glu Glu Gly Glu Asp Glu Glu Glu Pro Trp Glu Asp 
    370                 375                 380                 


Phe Asp Gly Thr Trp Thr Glu Glu Gln Gly Ile Leu Trp Leu Ala Pro 
385                 390                 395                 400 


Thr His Pro Pro Asp Phe Gly Leu Pro Tyr Arg Pro Asn Phe Pro Gln 
                405                 410                 415     


Asp Gly Glu Pro Gln Arg Leu His Leu Glu Pro Thr Trp Pro Pro Pro 
            420                 425                 430         


Leu Ser Ala Pro Arg Gly Pro Tyr His Ser Ser Val Val Ser Ala Thr 
        435                 440                 445             


Arg Pro Met Val Ile Ser Ala Thr Arg Pro Thr Leu Pro Ser Ala His 
    450                 455                 460                 


Lys Thr Ser Val Ile Ser Ala Thr Arg Pro Pro Leu Ser Pro Val His 
465                 470                 475                 480 


Pro Pro Ala Met Ala Pro Ala Thr Pro Pro Ala Val Phe Ser Glu His 
                485                 490                 495     


Gln Ile Pro Lys Ile Lys Ala Asn Tyr Pro Asp Leu Pro Phe Gly His 
            500                 505                 510         


Lys Pro Gly Ile Thr Ser Ala Thr His Pro Ala Arg Ser Pro Pro Tyr 
        515                 520                 525             


Gln Pro Pro Ile Ile Ser Thr Asn Tyr Pro Gln Val Phe Pro Pro His 
    530                 535                 540                 


Gln Ala Pro Met Ser Pro Asp Thr His Thr Ile Thr Tyr Leu Pro Pro 
545                 550                 555                 560 


Val Pro Pro His Leu Asp Pro Gly Asp Thr Thr Ser Lys Ala His Gln 
                565                 570                 575     


His Pro Leu Leu Pro Asp Ala Pro Gly Ile Arg Thr Gln Ala Pro Gln 
            580                 585                 590         


Leu Ser Val Ser Ala Leu Gln Pro Pro Leu Pro Thr Asn Ser Arg Ser 
        595                 600                 605             


Ser Val His Glu Thr Pro Val Pro Ala Ala Asn Gln Pro Pro Ala Phe 
    610                 615                 620                 


Pro Ser Ser Pro Leu Pro Pro Gln Arg Pro Thr Asn Gln Thr Ser Ser 
625                 630                 635                 640 


Ile Ser Pro Thr His Ser Tyr Ser Arg Ala Pro Leu Val Pro Arg Glu 
                645                 650                 655     


Gly Val Pro Ser Pro Lys Ser Val Pro Gln Leu Pro Ser Val Pro Ser 
            660                 665                 670         


Thr Ala Ala Pro Thr Ala Leu Ala Glu Ser Gly Leu Ala Gly Gln Ser 
        675                 680                 685             


Gln Arg Asp Asp Arg Trp Leu Leu Val Ala Leu Leu Val Pro Thr Cys 
    690                 695                 700                 


Val Phe Leu Val Val Leu Leu Ala Leu Gly Ile Val Tyr Cys Thr Arg 
705                 710                 715                 720 


Cys Gly Ser His Ala Pro Asn Lys Arg Ile Thr Asp Cys Tyr Arg Trp 
                725                 730                 735     


Val Thr His Ala Gly Asn Lys Ser Ser Thr Glu Pro Met Pro Pro Arg 
            740                 745                 750         


Gly Ser Leu Thr Gly Val Gln Thr Cys Arg Thr Ser Val 
        755                 760                 765 


<210>  3
<211>  744
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Met Asp Trp Pro Val His Leu Leu Leu Leu Val Leu Phe Trp Ala Ser 
1               5                   10                  15      


Pro Ala Met Ala Gln Pro Val Leu Thr Gln Pro Pro Ser Ala Ser Gly 
            20                  25                  30          


Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn 
        35                  40                  45              


Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile 
                85                  90                  95      


Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp 
            100                 105                 110         


Asp Asp Ser Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr 
        115                 120                 125             


Val Leu Gly Gln Pro Lys Ala Arg Gln Glu Gly Gly Ser Gly Glu Gly 
    130                 135                 140                 


Gly Ser Gly Glu Ser Asn Ala Ala Ala Gln Val Gln Leu Val Glu Ser 
145                 150                 155                 160 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Glu 
                165                 170                 175     


Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln 
            180                 185                 190         


Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Ser Gly Ser Gly 
        195                 200                 205             


Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
    210                 215                 220                 


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
225                 230                 235                 240 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ala Pro Gly Phe Asp 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Ala Ser 
            260                 265                 270         


Ala Ser Thr Val Tyr Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn 
        275                 280                 285             


Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys 
    290                 295                 300                 


Pro Ser Pro Leu Phe Pro Gly Pro Ser Arg Pro Phe Trp Val Leu Val 
305                 310                 315                 320 


Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala 
                325                 330                 335     


Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Val Leu His Ser 
            340                 345                 350         


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
        355                 360                 365             


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Gly 
    370                 375                 380                 


Pro Arg Tyr Gln Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Leu Asn 
                485                 490                 495     


Arg Gln Gly Ser Pro Gly Pro Val Ala Thr Met Ser Gly Gly Glu Glu 
            500                 505                 510         


Leu Phe Ala Gly Ile Val Pro Val Leu Ile Glu Leu Asp Gly Asp Val 
        515                 520                 525             


His Gly His Lys Phe Ser Val Arg Gly Glu Gly Glu Gly Asp Ala Asp 
    530                 535                 540                 


Tyr Gly Lys Leu Glu Ile Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
545                 550                 555                 560 


Val Pro Trp Pro Thr Leu Val Thr Thr Leu Cys Tyr Gly Ile Gln Cys 
                565                 570                 575     


Phe Ala Arg Tyr Pro Glu His Met Lys Met Asn Asp Phe Phe Lys Ser 
            580                 585                 590         


Ala Met Pro Glu Gly Tyr Ile Gln Glu Arg Thr Ile Gln Phe Gln Asp 
        595                 600                 605             


Asp Gly Lys Tyr Lys Thr Arg Gly Glu Val Lys Phe Glu Gly Asp Thr 
    610                 615                 620                 


Leu Val Asn Arg Ile Glu Leu Lys Gly Lys Asp Phe Lys Glu Asp Gly 
625                 630                 635                 640 


Asn Ile Leu Gly His Lys Leu Glu Tyr Ser Phe Asn Ser His Asn Val 
                645                 650                 655     


Tyr Ile Arg Pro Asp Lys Ala Asn Asn Gly Leu Glu Ala Asn Phe Lys 
            660                 665                 670         


Thr Arg His Asn Ile Glu Gly Gly Gly Val Gln Leu Ala Asp His Tyr 
        675                 680                 685             


Gln Thr Asn Val Pro Leu Gly Asp Gly Pro Val Leu Ile Pro Ile Asn 
    690                 695                 700                 


His Tyr Leu Ser Thr Gln Thr Lys Ile Ser Lys Asp Arg Asn Glu Ala 
705                 710                 715                 720 


Arg Asp His Met Val Leu Leu Glu Ser Phe Ser Ala Cys Cys His Thr 
                725                 730                 735     


His Gly Met Asp Glu Leu Tyr Arg 
            740                 


<210>  4
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Met Asp Trp Pro Val His Leu Leu Val Leu Leu Leu Phe Trp Ile Pro 
1               5                   10                  15      


Gly Val Arg Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser 
        35                  40                  45              


Phe Thr Gly Tyr Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys 
                85                  90                  95      


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Glu Leu Val 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
225                 230                 235                 240 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Met Ala Gln Pro Val Leu Thr Gln Pro Pro Ser Ala 
            260                 265                 270         


Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser 
        275                 280                 285             


Ser Asn Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly 
    290                 295                 300                 


Thr Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly 
305                 310                 315                 320 


Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu 
                325                 330                 335     


Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala 
            340                 345                 350         


Ala Trp Asp Asp Ser Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys 
        355                 360                 365             


Leu Thr Val Leu Gly Gln Pro Lys Ala Arg Gln Glu Gly Gly Ser Gly 
    370                 375                 380                 


Glu Gly Gly Ser Gly Glu Ser Asn Ala Ala Ala Gln Val Gln Leu Val 
385                 390                 395                 400 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                405                 410                 415     


Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val 
            420                 425                 430         


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Ser Gly 
        435                 440                 445             


Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
    450                 455                 460                 


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
465                 470                 475                 480 


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ala Pro Gly 
                485                 490                 495     


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser 
            500                 505                 510         


Ala Ser Ala Ser Thr His His His His His His His 
        515                 520                 


<210>  5
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Met Asp Trp Pro Val His Leu Leu Val Leu Leu Leu Phe Trp Ile Pro 
1               5                   10                  15      


Gly Val Arg Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn 
            100                 105                 110         


Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Leu Ser Ser Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Ser Met Ala Gln Pro Val Leu Thr Gln Pro 
                245                 250                 255     


Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser 
            260                 265                 270         


Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln Gln 
        275                 280                 285             


Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg 
    290                 295                 300                 


Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser 
305                 310                 315                 320 


Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr 
                325                 330                 335     


Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val Phe Gly Gly 
            340                 345                 350         


Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Arg Gln Glu Gly 
        355                 360                 365             


Gly Ser Gly Glu Gly Gly Ser Gly Glu Ser Asn Ala Ala Ala Gln Val 
    370                 375                 380                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
385                 390                 395                 400 


Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
                405                 410                 415     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly 
            420                 425                 430         


Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
        435                 440                 445             


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
    450                 455                 460                 


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
465                 470                 475                 480 


Ala Pro Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                485                 490                 495     


Ser Gly Ser Ala Ser Ala Ser Thr 
            500                 


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Ala Lys Ala Pro Gly Phe Asp Tyr 
1               5               


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Ser Ser Asn Ile Gly Ser Asn Thr 
1               5               


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 
1               5                   10      


<210>  11
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Ser Tyr Ala Met Ser 
1               5   


<210>  12
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Gly Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  13
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Ala Pro Gly Phe Asp Tyr 
1               5       


<210>  14
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10              


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Ser Asn Asn Gln Arg Pro Ser 
1               5           


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 
1               5                   10      


<210>  17
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Pro Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser 
        


<210>  18
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Gln Pro Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  19
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10              


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  21
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21

Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Met Ala 
1               5                   10                  15  


<210>  22
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ala 
1               5                   10          


<210>  23
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
1               5                   10  


<210>  24
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Met Ala 
            20          


<210>  25
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Ala Arg Gln Glu Gly Gly Ser Gly Glu Gly Gly Ser Gly Glu Ser Asn 
1               5                   10                  15      


Ala Ala Ala 
            


<210>  26
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26

Gly Gln Pro Lys Ala Arg Gln Glu Gly Gly Ser Gly Glu Gly Gly Ser 
1               5                   10                  15      


Gly Glu Ser Asn Ala Ala Ala 
            20              


<210>  27
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  28
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  29
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  29

Leu Pro Gly Ile Pro Pro Asn His Ala Pro Leu Val Thr Thr Leu Gly 
1               5                   10                  15      


Ala Gln Leu Pro Pro Gln Ala Pro Asp Ala Leu Val Leu Arg Thr Gln 
            20                  25                  30          


Ala Thr Gln Leu Pro Ile Ile Pro Thr Ala Gln Pro Ser Leu Thr Thr 
        35                  40                  45              


Thr Ser Arg Ser Pro Val Ser Pro Ala His Gln Ile Ser Val Pro Ala 
    50                  55                  60                  


Ala Thr Gln Pro Ala Ala Leu Pro Thr Leu Leu Pro Ser Gln Ser Pro 
65                  70                  75                  80  


Thr Asn Gln Thr Ser Pro Ile Ser Pro Thr His Pro His Ser Lys Ala 
                85                  90                  95      


Pro Gln Ile Pro Arg Glu Asp Gly Pro Ser Pro Lys Leu Ala Leu Trp 
            100                 105                 110         


Leu Pro Ser Pro Ala Pro Thr Ala Ala Pro Thr Ala Leu Gly Glu Ala 
        115                 120                 125             


Gly Leu Ala Glu His Ser Gln Arg Asp 
    130                 135         


<210>  30
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  30

Leu Pro Ser Pro Ala Pro Thr Ala Ala Pro Thr Ala Leu Gly Glu Ala 
1               5                   10                  15      


Gly Leu Ala Glu His Ser Gln Arg Asp 
            20                  25  


<210>  31
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  31

Ser Pro Thr His Pro His Ser Lys Ala Pro Gln Ile Pro Arg Glu Asp 
1               5                   10                  15      


Gly Pro Ser Pro Lys Leu Ala Leu Trp Leu Pro Ser Pro Ala Pro Thr 
            20                  25                  30          


Ala Ala Pro Thr Ala Leu Gly Glu Ala Gly Leu Ala Glu His Ser Gln 
        35                  40                  45              


Arg Asp 
    50  


<210>  32
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  32

Pro Ala Ala Thr Gln Pro Ala Ala Leu Pro Thr Leu Leu Pro Ser Gln 
1               5                   10                  15      


Ser Pro Thr Asn Gln Thr Ser Pro Ile Ser Pro Thr His Pro His Ser 
            20                  25                  30          


Lys Ala Pro Gln Ile Pro Arg Glu Asp Gly Pro Ser Pro Lys Leu Ala 
        35                  40                  45              


Leu Trp Leu Pro Ser Pro Ala Pro Thr Ala Ala Pro Thr Ala Leu Gly 
    50                  55                  60                  


Glu Ala Gly Leu Ala Glu His Ser Gln Arg Asp 
65                  70                  75  


<210>  33
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  33

Pro Ile Ile Pro Thr Ala Gln Pro Ser Leu Thr Thr Thr Ser Arg Ser 
1               5                   10                  15      


Pro Val Ser Pro Ala His Gln Ile Ser Val Pro Ala Ala Thr Gln Pro 
            20                  25                  30          


Ala Ala Leu Pro Thr Leu Leu Pro Ser Gln Ser Pro Thr Asn Gln Thr 
        35                  40                  45              


Ser Pro Ile Ser Pro Thr His Pro His Ser Lys Ala Pro Gln Ile Pro 
    50                  55                  60                  


Arg Glu Asp Gly Pro Ser Pro Lys Leu Ala Leu Trp Leu Pro Ser Pro 
65                  70                  75                  80  


Ala Pro Thr Ala Ala Pro Thr Ala Leu Gly Glu Ala Gly Leu Ala Glu 
                85                  90                  95      


His Ser Gln Arg Asp 
            100     


<210>  34
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  34

Leu Pro Gly Ile Pro Pro Asn His Ala Pro Leu Val Thr Thr Leu Gly 
1               5                   10                  15      


Ala Gln Leu Pro Pro Gln Ala Pro Asp Ala Leu Val Leu Arg 
            20                  25                  30  


<210>  35
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  35

Ala Pro Asp Ala Leu Val Leu Arg Thr Gln Ala Thr Gln Leu Pro Ile 
1               5                   10                  15      


Ile Pro Thr Ala Gln Pro Ser Leu Thr Thr Thr Ser Arg Ser 
            20                  25                  30  


<210>  36
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  36

Ser Leu Thr Thr Thr Ser Arg Ser Pro Val Ser Pro Ala His Gln Ile 
1               5                   10                  15      


Ser Val Pro Ala Ala Thr Gln Pro Ala Ala Leu Pro Thr Leu 
            20                  25                  30  


<210>  37
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  37

Gln Pro Ala Ala Leu Pro Thr Leu Leu Pro Ser Gln Ser Pro Thr Asn 
1               5                   10                  15      


Gln Thr Ser Pro Ile Ser Pro Thr His Pro His Ser Lys Ala 
            20                  25                  30  


<210>  38
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  38

Pro Thr His Pro His Ser Lys Ala Pro Gln Ile Pro Arg Glu Asp Gly 
1               5                   10                  15      


Pro Ser Pro Lys Leu Ala Leu Trp Leu Pro Ser Pro Ala Pro 
            20                  25                  30  


<210>  39
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  39

Pro Gln Ile Pro Arg Glu Asp Gly Pro Ser Pro Lys Leu Ala Leu Trp 
1               5                   10                  15      


<210>  40
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  40

Pro Leu Val Pro Arg Glu Gly Val Pro Ser Pro Lys Ser Val Pro Gln 
1               5                   10                  15      


