                               SEQUENCE LISTING

<110> GRADALIS, INC.
 
<120> METHODS FOR TREATING CANCERS

<130> 097999-003610PC-1303023

<140> PCT/US2022/019492
<141> 2022-03-09

<150> 63/159,341
<151> 2021-03-10

<160> 8     

<170> PatentIn version 3.5

<210> 1
<211> 4180
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      mRNA transcript encoding furin sequence

<400> 1
gcggggaagc agcagcggcc aggatgaatc ccaggtgctc tggagctgga tggtgaaggt       60

cggcactctt caccctcccg agccctgccc gtctcggccc catgccccca ccagtcagcc      120

ccgggccaca ggcagtgagc aggcacctgg gagccgaggc cctgtgacca ggccaaggag      180

acgggcgctc cagggtccca gccacctgtc ccccccatgg agctgaggcc ctggttgcta      240

tgggtggtag cagcaacagg aaccttggtc ctgctagcag ctgatgctca gggccagaag      300

gtcttcacca acacgtgggc tgtgcgcatc cctggaggcc cagcggtggc caacagtgtg      360

gcacggaagc atgggttcct caacctgggc cagatcttcg gggactatta ccacttctgg      420

catcgaggag tgacgaagcg gtccctgtcg cctcaccgcc cgcggcacag ccggctgcag      480

agggagcctc aagtacagtg gctggaacag caggtggcaa agcgacggac taaacgggac      540

gtgtaccagg agcccacaga ccccaagttt cctcagcagt ggtacctgtc tggtgtcact      600

cagcgggacc tgaatgtgaa ggcggcctgg gcgcagggct acacagggca cggcattgtg      660

gtctccattc tggacgatgg catcgagaag aaccacccgg acttggcagg caattatgat      720

cctggggcca gttttgatgt caatgaccag gaccctgacc cccagcctcg gtacacacag      780

atgaatgaca acaggcacgg cacacggtgt gcgggggaag tggctgcggt ggccaacaac      840

ggtgtctgtg gtgtaggtgt ggcctacaac gcccgcattg gaggggtgcg catgctggat      900

ggcgaggtga cagatgcagt ggaggcacgc tcgctgggcc tgaaccccaa ccacatccac      960

atctacagtg ccagctgggg ccccgaggat gacggcaaga cagtggatgg gccagcccgc     1020

ctcgccgagg aggccttctt ccgtggggtt agccagggcc gaggggggct gggctccatc     1080

tttgtctggg cctcggggaa cgggggccgg gaacatgaca gctgcaactg cgacggctac     1140

accaacagta tctacacgct gtccatcagc agcgccacgc agtttggcaa cgtgccgtgg     1200

tacagcgagg cctgctcgtc cacactggcc acgacctaca gcagtggcaa ccagaatgag     1260

aagcagatcg tgacgactga cttgcggcag aagtgcacgg agtctcacac gggcacctca     1320

gcctctgccc ccttagcagc cggcatcatt gctctcaccc tggaggccaa taagaacctc     1380

acatggcggg acatgcaaca cctggtggta cagacctcga agccagccca cctcaatgcc     1440

aacgactggg ccaccaatgg tgtgggccgg aaagtgagcc actcatatgg ctacgggctt     1500

ttggacgcag gcgccatggt ggccctggcc cagaattgga ccacagtggc cccccagcgg     1560

aagtgcatca tcgacatcct caccgagccc aaagacatcg ggaaacggct cgaggtgcgg     1620

aagaccgtga ccgcgtgcct gggcgagccc aaccacatca ctcggctgga gcacgctcag     1680

gcgcggctca ccctgtccta taatcgccgt ggcgacctgg ccatccacct ggtcagcccc     1740

atgggcaccc gctccaccct gctggcagcc aggccacatg actactccgc agatgggttt     1800

aatgactggg ccttcatgac aactcattcc tgggatgagg atccctctgg cgagtgggtc     1860

ctagagattg aaaacaccag cgaagccaac aactatggga cgctgaccaa gttcaccctc     1920

gtactctatg gcaccgcccc tgaggggctg cccgtacctc cagaaagcag tggctgcaag     1980

accctcacgt ccagtcaggc ctgtgtggtg tgcgaggaag gcttctccct gcaccagaag     2040

agctgtgtcc agcactgccc tccagggttc gccccccaag tcctcgatac gcactatagc     2100

accgagaatg acgtggagac catccgggcc agcgtctgcg ccccctgcca cgcctcatgt     2160

gccacatgcc aggggccggc cctgacagac tgcctcagct gccccagcca cgcctccttg     2220

gaccctgtgg agcagacttg ctcccggcaa agccagagca gccgagagtc cccgccacag     2280

cagcagccac ctcggctgcc cccggaggtg gaggcggggc aacggctgcg ggcagggctg     2340

ctgccctcac acctgcctga ggtggtggcc ggcctcagct gcgccttcat cgtgctggtc     2400

ttcgtcactg tcttcctggt cctgcagctg cgctctggct ttagttttcg gggggtgaag     2460

gtgtacacca tggaccgtgg cctcatctcc tacaaggggc tgccccctga agcctggcag     2520

gaggagtgcc cgtctgactc agaagaggac gagggccggg gcgagaggac cgcctttatc     2580

aaagaccaga gcgccctctg atgagcccac tgcccacccc ctcaagccaa tcccctcctt     2640

gggcactttt taattcacca aagtattttt ttatcttggg actgggtttg gaccccagct     2700

gggaggcaag aggggtggag actgcttccc atcctaccct cgggcccacc tggccacctg     2760

aggtgggccc aggaccagct ggggcgtggg gagggccgta ccccaccctc agcacccctt     2820

ccatgtggag aaaggagtga aacctttagg gcagcttgcc ccggccccgg ccccagccag     2880

agttcctgcg gagtgaagag gggcagccct tgcttgttgg gattcctgac ccaggccgca     2940

gctcttgccc ttccctgtcc ctctaaagca ataatggtcc catccaggca gtcgggggct     3000

ggcctaggag atatctgagg gaggaggcca cctctccaag ggcttctgca ccctccaccc     3060

tgtcccccag ctctggtgag tcttggcggc agcagccatc ataggaaggg accaaggcaa     3120

ggcaggtgcc tccaggtgtg cacgtggcat gtggcctgtg gcctgtgtcc catgacccac     3180

ccctgtgctc cgtgcctcca ccaccactgg ccaccaggct ggcgcagcca aggccgaagc     3240

tctggctgaa ccctgtgctg gtgtcctgac caccctcccc tctcttgcac ccgcctctcc     3300

cgtcagggcc caagtccctg ttttctgagc ccgggctgcc tgggctgttg gcactcacag     3360

acctggagcc cctgggtggg tggtggggag gggcgctggc ccagccggcc tctctggcct     3420

cccacccgat gctgctttcc cctgtgggga tctcaggggc tgtttgagga tatattttca     3480

ctttgtgatt atttcacttt agatgctgat gatttgtttt tgtattttta atgggggtag     3540

cagctggact acccacgttc tcacacccac cgtccgccct gctcctccct ggctgccctg     3600

gccctgaggt gtgggggctg cagcatgttg ctgaggagtg aggaatagtt gagccccaag     3660

tcctgaagag gcgggccagc caggcgggct caaggaaagg gggtcccagt gggaggggca     3720

ggctgacatc tgtgtttcaa gtggggctcg ccatgccggg ggttcatagg tcactggctc     3780

tccaagtgcc agaggtgggc aggtggtggc actgagcccc cccaacactg tgccctggtg     3840

gagaaagcac tgacctgtca tgcccccctc aaacctcctc ttctgacgtg ccttttgcac     3900

ccctcccatt aggacaatca gtcccctccc atctgggagt ccccttttct tttctaccct     3960

agccattcct ggtacccagc catctgccca ggggtgcccc ctcctctccc atccccctgc     4020

cctcgtggcc agcccggctg gttttgtaag atgctgggtt ggtgcacagt gatttttttc     4080

ttgtaattta aacaggccca gcattgctgg ttctatttaa tggacatgag ataatgttag     4140

aggttttaaa gtgattaaac gtgcagacta tgcaaaccag                           4180


<210> 2
<211> 245
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 2
gauccugcug uugacaguga gcgcggagaa aggagugaaa ccuuagugaa gccacagaug       60

uaagguuuca cuccuuucuc cuugccuacu gccucggaag cagcucacua cauuacucag      120

cuguugacag ugagcgcgga gaaagauaug aaaccuuagu gaagccacag auguaagguu      180

ucacuccuuu cuccuugccu acugccucgg aagcuuaaua aaggaucuuu uauuuucauu      240

ggauc                                                                  245


<210> 3
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3
ggagaaagga gugaaaccuu a                                                 21


<210> 4
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 4
uaagguuuca cuccuuucuc c                                                 21


<210> 5
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
ggagaaagau augaaaccuu a                                                 21


<210> 6
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
gugaagccac agaug                                                        15


<210> 7
<211> 5140
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 7
ggccattgca tacgttgtat ccatatcata atatgtacat ttatattggc tcatgtccaa       60

cattaccgcc atgttgacat tgattattga ctagttatta atagtaatca attacggggt      120

cattagttca tagcccatat atggagttcc gcgttacata acttacggta aatggcccgc      180

ctggctgacc gcccaacgac ccccgcccat tgacgtcaat aatgacgtat gttcccatag      240

taacgccaat agggactttc cattgacgtc aatgggtgga gtatttacgg taaactgccc      300

acttggcagt acatcaagtg tatcatatgc caagtacgcc ccctattgac gtcaatgacg      360

gtaaatggcc cgcctggcat tatgcccagt acatgacctt atgggacttt cctacttggc      420

agtacatcta cgtattagtc atcgctatta ccatggtgat gcggttttgg cagtacatca      480

atgggcgtgg atagcggttt gactcacggg gatttccaag tctccacccc attgacgtca      540

atgggagttt gttttggcac caaaatcaac gggactttcc aaaatgtcgt aacaactccg      600

ccccattgac gcaaatgggc ggtaggcgtg tacggtggga ggtctatata agcagagctc      660

gtttagtgaa ccgtcagatc gcctggagac gccatccacg ctgttttgac ctccatagaa      720

gacaccggga ccgatccagc ctccgcggcc gggaacggtg cattggaacg cggattcccc      780

gtgccaagag tgacgtaagt accgcctata gactctatag gcacacccct ttggctctta      840

tgcatgctat actgtttttg gcttggggcc tatacacccc cgcttcctta tgctataggt      900

gatggtatag cttagcctat aggtgtgggt tattgaccat tattgaccac tccaacggtg      960

gagggcagtg tagtctgagc agtactcgtt gctgccgcgc gcgccaccag acataatagc     1020

tgacagacta acagactgtt cctttccatg ggtcttttct gcagtcaccg tcgtcgacgg     1080

tatcgataag cttgatatcg aattccgctg gaggatgtgg ctgcagagcc tgctgctctt     1140

gggcactgtg gcctgcagca tctctgcacc cgcccgctcg cccagcccca gcacgcagcc     1200

ctgggagcat gtgaatgcca tccaggaggc ccggcgtctc ctgaacctga gtagagacac     1260

tgctgctgag atgaatgaaa cagtagaagt catctcagaa atgtttgacc tccaggagcc     1320

gacctgccta cagacccgcc tggagctgta caagcagggc ctgcggggca gcctcaccaa     1380

gctcaagggc cccttgacca tgatggccag ccactacaag cagcactgcc ctccaacccc     1440

ggaaacttcc tgtgcaaccc agactatcac ctttgaaagt ttcaaagaga acctgaagga     1500

ctttctgctt gtcatcccct ttgactgctg ggagccagtc caggagtgag accggccaga     1560

tgaggctggc caagccgggg agctgctctc tcatgaaaca agagctagaa actcaggatg     1620

gtcatcttgg agggaccaag gggtgggcca cagccatggt gggagtggcc tggacctgcc     1680

ctgggccaca ctgaccctga tacaggcatg gcagaagaat gggaatattt tatactgaca     1740

gaaatcagta atatttatat atttatattt ttaaaatatt tatttattta tttatttaag     1800

ttcatattcc atatttattc aagatgtttt accgtaataa ttattattaa aaatatgctt     1860

ctaaaaaaaa aaaaaaaaaa aaaaacggaa ttcacgtggg cccggtaccg tatactctag     1920

aagatctggc agcggagagg gcagaggaag tcttctaaca tgcggtgacg tggaggagaa     1980

tcccggccct aggatgtcta gagcggccgc ggatcctgct gttgacagtg agcgcggaga     2040

aaggagtgaa accttagtga agccacagat gtaaggtttc actcctttct ccttgcctac     2100

tgcctcggaa gcagctcact acattactca gctgttgaca gtgagcgcgg agaaagatat     2160

gaaaccttag tgaagccaca gatgtaaggt ttcactcctt tctccttgcc tactgcctcg     2220

gaagcttaat aaaggatctt ttattttcat tggatccaga tctttttccc tctgccaaaa     2280

attatgggga catcatgaag ccccttgagc atctgacttc tggctaataa aggaaattta     2340

ttttcattgc aatagtgtgt tggaattttt tgtgtctctc actcggaagg acatatggga     2400

gggcaaatca tttaaaacat cagaatgagt atttggttta gagtttggca acatatgccc     2460

attcttccgc ttcctcgctc actgactcgc tgcgctcggt cgttcggctg cggcgagcgg     2520

tatcagctca ctcaaaggcg gtaatacggt tatccacaga atcaggggat aacgcaggaa     2580

agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg     2640

cgtttttcca taggctccgc ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga     2700

ggtggcgaaa cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg     2760

tgcgctctcc tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg     2820

gaagcgtggc gctttctcat agctcacgct gtaggtatct cagttcggtg taggtcgttc     2880

gctccaagct gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc gccttatccg     2940

gtaactatcg tcttgagtcc aacccggtaa gacacgactt atcgccactg gcagcagcca     3000

ctggtaacag gattagcaga gcgaggtatg taggcggtgc tacagagttc ttgaagtggt     3060

ggcctaacta cggctacact agaagaacag tatttggtat ctgcgctctg ctgaagccag     3120

ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg     3180

gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc     3240

ctttgatctt ttctacgggg tctgacgctc agtggaacga aaactcacgt taagggattt     3300

tggtcatgag attatcaaaa aggatcttca cctagatcct tttaaattaa aaatgaagtt     3360

ttaaatcaat ctaaagtata tatgagtaaa cttggtctga cagttaccaa tgcttaatca     3420

gtgaggcacc tatctcagcg atctgtctat ttcgttcatc catagttgcc tgactcgggg     3480

ggggggggcg ctgaggtctg cctcgtgaag aaggtgttgc tgactcatac caggcctgaa     3540

tcgccccatc atccagccag aaagtgaggg agccacggtt gatgagagct ttgttgtagg     3600

tggaccagtt ggtgattttg aacttttgct ttgccacgga acggtctgcg ttgtcgggaa     3660

gatgcgtgat ctgatccttc aactcagcaa aagttcgatt tattcaacaa agccgccgtc     3720

ccgtcaagtc agcgtaatgc tctgccagtg ttacaaccaa ttaaccaatt ctgattagaa     3780

aaactcatcg agcatcaaat gaaactgcaa tttattcata tcaggattat caataccata     3840

tttttgaaaa agccgtttct gtaatgaagg agaaaactca ccgaggcagt tccataggat     3900

ggcaagatcc tggtatcggt ctgcgattcc gactcgtcca acatcaatac aacctattaa     3960

tttcccctcg tcaaaaataa ggttatcaag tgagaaatca ccatgagtga cgactgaatc     4020

cggtgagaat ggcaaaagct tatgcatttc tttccagact tgttcaacag gccagccatt     4080

acgctcgtca tcaaaatcac tcgcatcaac caaaccgtta ttcattcgtg attgcgcctg     4140

agcgagacga aatacgcgat cgctgttaaa aggacaatta caaacaggaa tcgaatgcaa     4200

ccggcgcagg aacactgcca gcgcatcaac aatattttca cctgaatcag gatattcttc     4260

taatacctgg aatgctgttt tcccggggat cgcagtggtg agtaaccatg catcatcagg     4320

agtacggata aaatgcttga tggtcggaag aggcataaat tccgtcagcc agtttagtct     4380

gaccatctca tctgtaacat cattggcaac gctacctttg ccatgtttca gaaacaactc     4440

tggcgcatcg ggcttcccat acaatcgata gattgtcgca cctgattgcc cgacattatc     4500

gcgagcccat ttatacccat ataaatcagc atccatgttg gaatttaatc gcggcctcga     4560

gcaagacgtt tcccgttgaa tatggctcat aacacccctt gtattactgt ttatgtaagc     4620

agacagtttt attgttcatg atgatatatt tttatcttgt gcaatgtaac atcagagatt     4680

ttgagacaca acgtggcttt cccccccccc ccattattga agcatttatc agggttattg     4740

tctcatgagc ggatacatat ttgaatgtat ttagaaaaat aaacaaatag gggttccgcg     4800

cacatttccc cgaaaagtgc cacctgacgt ctaagaaacc attattatca tgacattaac     4860

ctataaaaat aggcgtatca cgaggccctt tcgtctcgcg cgtttcggtg atgacggtga     4920

aaacctctga cacatgcagc tcccggagac ggtcacagct tgtctgtaag cggatgccgg     4980

gagcagacaa gcccgtcagg gcgcgtcagc gggtgttggc gggtgtcggg gctggcttaa     5040

ctatgcggca tcagagcaga ttgtactgag agtgcaccat atgcggtgtg aaataccgca     5100

cagatgcgta aggagaaaat accgcatcag attggctatt                           5140


<210> 8
<211> 223
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 8
gauccugcug uugacaguga gcgcggagaa aggagugaaa ccuuagugaa gccacagaug       60

uaagguuuca cuccuuucuc cuugccuacu gccucggaag cagcucacua cauuacucag      120

cuguugacag ugagcgcgga gaaagauaug aaaccuuagu gaagccacag auguaagguu      180

ucacuccuuu cuccuugccu acugccucgg aagcuuaaua aag                        223


