                         SEQUENCE LISTING

<110>  Northwestern University
 
<120>  ANTIVIRAL VACCINES USING SPHERICAL NUCLEIC ACIDS

<130>  30938/2021-003R

<150>  US 63/160,600
<151>  2021-03-12

<150>  US 63/250,908
<151>  2021-09-30

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  8537
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1
gtcgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atggtcgagg tgagccccac gttctgcttc actctcccca      420

tctccccccc ctccccaccc ccaattttgt atttatttat tttttaatta ttttgtgcag      480

cgatgggggc gggggggggg ggggcgcgcg ccaggcgggg cggggcgggg cgaggggcgg      540

ggcggggcga ggcggagagg tgcggcggca gccaatcaga gcggcgcgct ccgaaagttt      600

ccttttatgg cgaggcggcg gcggcggcgg ccctataaaa agcgaagcgc gcggcgggcg      660

ggagtcgctg cgcgcgctgc cttcgccccg tgccccgctc cgccgccgcc tcgcgccgcc      720

cgccccggct ctgactgacc gcgttactcc cacaggtgag cgggcgggac ggcccttctc      780

ctccgggctg taattagcgc ttggtttaat gacggcttgt ttcttttctg tggctgcgtg      840

aaagccttga ggggctccgg gagggccctt tgtgcggggg gagcggctcg gggggtgcgt      900

gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc gctgcccggc ggctgtgagc      960

gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt gcgcgagggg agcgcggccg     1020

ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa caaaggctgc gtgcggggtg     1080

tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt cgggctgcaa ccccccctgc     1140

acccccctcc ccgagttgct gagcacggcc cggcttcggg tgcggggctc cgtacggggc     1200

gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca ggtgggggtg ccgggcgggg     1260

cggggccgcc tcgggccggg gagggctcgg gggaggggcg cggcggcccc cggagcgccg     1320

gcggctgtcg aggcgcggcg agccgcagcc attgcctttt atggtaatcg tgcgagaggg     1380

cgcagggact tcctttgtcc caaatctggc ggagccgaaa tctgggaggc gccgccgcac     1440

cccctctagc gggcgcgggg cgaagcggtg cggcgccggc aggaaggaaa tgggcgggga     1500

gggccttcgt gcgtcgccgc gccgccgtcc ccttctccct ctccagcctc ggggctgtcc     1560

gcggggggac ggctgccttc gggggggacg gggcagggcg gggttcggct tctggcgtgt     1620

gaccggcggc tctagagcct ctgctaacca tgttcatgcc ttcttctttt tcctacagct     1680

cctgggcaac gtgctggtta ttgtgctgtc tcatcatttt ggcaaaggcc accatgttcg     1740

tgtttctggt gctgctgcct ctggtgtcca gccagtgtgt gaacctgacc acaagaaccc     1800

agctgcctcc agcctacacc aacagcttta ccagaggcgt gtactacccc gacaaggtgt     1860

tcagatccag cgtgctgcac tctacccagg acctgttcct gcctttcttc agcaacgtga     1920

cctggttcca cgccatccac gtgtccggca ccaatggcac caagagattc gacaaccccg     1980

tgctgccctt caacgacggg gtgtactttg ccagcaccga gaagtccaac atcatcagag     2040

gctggatctt cggcaccaca ctggacagca agacccagag cctgctgatc gtgaacaacg     2100

ccaccaacgt ggtcatcaaa gtgtgcgagt tccagttctg caacgacccc ttcctgggcg     2160

tctactatca caagaacaac aagagctgga tggaaagcga gttccgggtg tacagcagcg     2220

ccaacaactg caccttcgag tacgtgtccc agcctttcct gatggacctg gaaggcaagc     2280

agggcaactt caagaacctg cgcgagttcg tgttcaagaa catcgacggc tacttcaaga     2340

tctacagcaa gcacacccct atcaacctcg tgcgggatct gcctcagggc ttctctgctc     2400

tggaacccct ggtggatctg cccatcggca tcaacatcac ccggtttcag acactgctgg     2460

ccctgcacag aagctacctg acacctggcg atagcagcag cggatggaca gctggtgccg     2520

ccgcttacta tgtgggctac ctgcagccta gaacctttct gctgaagtac aacgagaacg     2580

gcaccatcac cgacgccgtg gattgtgctc tggatcctct gagcgagaca aagtgcaccc     2640

tgaagtcctt caccgtggaa aagggcatct accagaccag caacttccgg gtgcagccca     2700

ccgaatccat cgtgcggttc cccaatatca ccaatctgtg ccccttcggc gaggtgttca     2760

atgccaccag attcgcctct gtgtacgcct ggaaccggaa gcggatcagc aattgcgtgg     2820

ccgactactc cgtgctgtac aactccgcca gcttcagcac cttcaagtgc tacggcgtgt     2880

cccctaccaa gctgaacgac ctgtgcttca caaacgtgta cgccgacagc ttcgtgatcc     2940

ggggagatga agtgcggcag attgcccctg gacagacagg caagatcgcc gactacaact     3000

acaagctgcc cgacgacttc accggctgtg tgattgcctg gaacagcaac aacctggact     3060

ccaaagtcgg cggcaactac aattacctgt accggctgtt ccggaagtcc aatctgaagc     3120

ccttcgagcg ggacatctcc accgagatct atcaggccgg cagcacccct tgtaacggcg     3180

tggaaggctt caactgctac ttcccactgc agtcctacgg ctttcagccc acaaatggcg     3240

tgggctatca gccctacaga gtggtggtgc tgagcttcga actgctgcat gcccctgcca     3300

cagtgtgcgg ccctaagaaa agcaccaatc tcgtgaagaa caaatgcgtg aacttcaact     3360

tcaacggcct gaccggcacc ggcgtgctga cagagagcaa caagaagttc ctgccattcc     3420

agcagtttgg ccgggatatc gccgatacca cagacgccgt tagagatccc cagacactgg     3480

aaatcctgga catcacccct tgcagcttcg gcggagtgtc tgtgatcacc cctggcacca     3540

acaccagcaa tcaggtggca gtgctgtacc aggacgtgaa ctgtaccgaa gtgcccgtgg     3600

ccattcacgc cgatcagctg acacctacat ggcgggtgta ctccaccggc agcaatgtgt     3660

ttcagaccag agccggctgt ctgatcggag ccgagcacgt gaacaatagc tacgagtgcg     3720

acatccccat cggcgctggc atctgtgcca gctaccagac acagacaaac agccccgcct     3780

ctgtggccag ccagagcatc attgcctaca caatgtctct gggcgccgag aacagcgtgg     3840

cctactccaa caactctatc gctatcccca ccaacttcac catcagcgtg accacagaga     3900

tcctgcctgt gtccatgacc aagaccagcg tggactgcac catgtacatc tgcggcgatt     3960

ccaccgagtg ctccaacctg ctgctgcagt acggcagctt ctgcacccag ctgaatagag     4020

ccctgacagg gatcgccgtg gaacaggaca agaacaccca agaggtgttc gcccaagtga     4080

agcagatcta caagacccct cctatcaagg acttcggcgg cttcaatttc agccagattc     4140

tgcccgatcc tagcaagccc agcaagcgga gcttcatcga ggacctgctg ttcaacaaag     4200

tgacactggc cgacgccggc ttcatcaagc agtatggcga ttgtctgggc gacattgccg     4260

ccagggatct gatttgcgcc cagaagttta acggactgac agtgctgcct cctctgctga     4320

ccgatgagat gatcgcccag tacacatctg ccctgctggc cggcacaatc acaagcggct     4380

ggacatttgg agctggcgcc gctctgcaga tcccctttgc tatgcagatg gcctaccggt     4440

tcaacggcat cggagtgacc cagaatgtgc tgtacgagaa ccagaagctg atcgccaacc     4500

agttcaacag cgccatcggc aagatccagg acagcctgag cagcacagca agcgccctgg     4560

gaaagctgca ggacgtggtc aaccagaatg cccaggcact gaacaccctg gtcaagcagc     4620

tgtcctccaa cttcggcgcc atcagctctg tgctgaacga tatcctgagc agactggacc     4680

ctcctgaagc cgaggtgcag atcgacagac tgatcaccgg aaggctgcag tccctgcaga     4740

cctacgttac ccagcagctg atcagagccg ccgagattag agcctctgcc aatctggccg     4800

ccaccaagat gtctgagtgt gtgctgggcc agagcaagag agtggacttt tgcggcaagg     4860

gctaccacct gatgagcttc cctcagtctg cccctcacgg cgtggtgttt ctgcacgtga     4920

catacgtgcc cgctcaagag aagaatttca ccaccgctcc agccatctgc cacgacggca     4980

aagcccactt tcctagagaa ggcgtgttcg tgtccaacgg cacccattgg ttcgtgaccc     5040

agcggaactt ctacgagccc cagatcatca ccaccgacaa caccttcgtg tctggcaact     5100

gcgacgtcgt gatcggcatt gtgaacaata ccgtgtacga ccctctgcag cccgagctgg     5160

acagcttcaa agaggaactg gataagtact ttaagaacca cacaagcccc gacgtggacc     5220

tgggcgatat cagcggaatc aatgccagcg tcgtgaacat ccagaaagag atcgaccggc     5280

tgaacgaggt ggccaagaat ctgaacgaga gcctgatcga cctgcaagaa ctggggaagt     5340

acgagcagta catcaagtgg cccagcggcc gcttggtccc acgtggctca cccggatctg     5400

gatacatccc ggaggcccct agggacggtc aagcttacgt gagaaaggac ggcgaatggg     5460

ttctgctgtc gaccttcttg ggacatcatc atcatcatca ctaatgaaat tcgagctcgc     5520

ggccgcatcg atcttaagtc gcgactcgag ctagcagatc tttttccctc tgccaaaaat     5580

tatggggaca tcatgaagcc ccttgagcat ctgacttctg gctaataaag gaaatttatt     5640

ttcattgcaa tagtgtgttg gaattttttg tgtctctcac tcggaaggac atatgggagg     5700

gcaaatcatt taaaacatca gaatgagtat ttggtttaga gtttggcaac atatgcccat     5760

atgctggctg ccatgaacaa aggttggcta taaagaggtc atcagtatat gaaacagccc     5820

cctgctgtcc attccttatt ccatagaaaa gccttgactt gaggttagat tttttttata     5880

ttttgttttg tgttattttt ttctttaaca tccctaaaat tttccttaca tgttttacta     5940

gccagatttt tcctcctctc ctgactactc ccagtcatag ctgtccctct tctcttatgg     6000

agatccctcg acctgcagcc caagcttggc gtaatcatgg tcatagctgt ttcctgtgtg     6060

aaattgttat ccgctcacaa ttccacacaa catacgagcc ggaagcataa agtgtaaagc     6120

ctggggtgcc taatgagtga gctaactcac attaattgcg ttgcgctcac tgcccgcttt     6180

ccagtcggga aacctgtcgt gccagcggat ccgcatctca attagtcagc aaccatagtc     6240

ccgcccctaa ctccgcccat cccgccccta actccgccca gttccgccca ttctccgccc     6300

catggctgac taattttttt tatttatgca gaggccgagg ccgcctcggc ctctgagcta     6360

ttccagaagt agtgaggagg cttttttgga ggcctaggct tttgcaaaaa gctaacttgt     6420

ttattgcagc ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag     6480

catttttttc actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg     6540

tctggatccg ctgcattaat gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg     6600

gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc     6660

ggtatcagct cactcaaagg cggtaatacg gttatccaca gaatcagggg ataacgcagg     6720

aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct     6780

ggcgtttttc cataggctcc gcccccctga cgagcatcac aaaaatcgac gctcaagtca     6840

gaggtggcga aacccgacag gactataaag ataccaggcg tttccccctg gaagctccct     6900

cgtgcgctct cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc     6960

gggaagcgtg gcgctttctc atagctcacg ctgtaggtat ctcagttcgg tgtaggtcgt     7020

tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc     7080

cggtaactat cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc     7140

cactggtaac aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg     7200

gtggcctaac tacggctaca ctagaagaac agtatttggt atctgcgctc tgctgaagcc     7260

agttaccttc ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag     7320

cggtggtttt tttgtttgca agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga     7380

tcctttgatc ttttctacgg ggtctgacgc tcagtggaac gaaaactcac gttaagggat     7440

tttggtcatg agattatcaa aaaggatctt cacctagatc cttttaaatt aaaaatgaag     7500

ttttaaatca atctaaagta tatatgagta aacttggtct gacagttacc aatgcttaat     7560

cagtgaggca cctatctcag cgatctgtct atttcgttca tccatagttg cctgactccc     7620

cgtcgtgtag ataactacga tacgggaggg cttaccatct ggccccagtg ctgcaatgat     7680

accgcgagac ccacgctcac cggctccaga tttatcagca ataaaccagc cagccggaag     7740

ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc atccagtcta ttaattgttg     7800

ccgggaagct agagtaagta gttcgccagt taatagtttg cgcaacgttg ttgccattgc     7860

tacaggcatc gtggtgtcac gctcgtcgtt tggtatggct tcattcagct ccggttccca     7920

acgatcaagg cgagttacat gatcccccat gttgtgcaaa aaagcggtta gctccttcgg     7980

tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta tcactcatgg ttatggcagc     8040

actgcataat tctcttactg tcatgccatc cgtaagatgc ttttctgtga ctggtgagta     8100

ctcaaccaag tcattctgag aatagtgtat gcggcgaccg agttgctctt gcccggcgtc     8160

aatacgggat aataccgcgc cacatagcag aactttaaaa gtgctcatca ttggaaaacg     8220

ttcttcgggg cgaaaactct caaggatctt accgctgttg agatccagtt cgatgtaacc     8280

cactcgtgca cccaactgat cttcagcatc ttttactttc accagcgttt ctgggtgagc     8340

aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat     8400

actcatactc ttcctttttc aatattattg aagcatttat cagggttatt gtctcatgag     8460

cggatacata tttgaatgta tttagaaaaa taaacaaata ggggttccgc gcacatttcc     8520

ccgaaaagtg ccacctg                                                    8537


<210>  2
<211>  1284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Met Phe Met Pro Ser Ser Phe Ser Tyr Ser Ser Trp Ala Thr Cys Trp 
1               5                   10                  15      


Leu Leu Cys Cys Leu Ile Ile Leu Ala Lys Ala Thr Met Phe Val Phe 
            20                  25                  30          


Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val Asn Leu Thr Thr 
        35                  40                  45              


Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val 
    50                  55                  60                  


Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln 
65                  70                  75                  80  


Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile 
                85                  90                  95      


His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu 
            100                 105                 110         


Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile 
        115                 120                 125             


Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser 
    130                 135                 140                 


Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu 
145                 150                 155                 160 


Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn 
                165                 170                 175     


Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn 
            180                 185                 190         


Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu 
        195                 200                 205             


Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn 
    210                 215                 220                 


Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu 
225                 230                 235                 240 


Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp 
                245                 250                 255     


Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu 
            260                 265                 270         


His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala 
        275                 280                 285             


Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu 
    290                 295                 300                 


Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala 
305                 310                 315                 320 


Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val 
                325                 330                 335     


Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu 
            340                 345                 350         


Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu 
        355                 360                 365             


Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys 
    370                 375                 380                 


Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala 
385                 390                 395                 400 


Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn 
                405                 410                 415     


Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly 
            420                 425                 430         


Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp 
        435                 440                 445             


Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp 
    450                 455                 460                 


Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu 
465                 470                 475                 480 


Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile 
                485                 490                 495     


Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu 
            500                 505                 510         


Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr 
        515                 520                 525             


Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu 
    530                 535                 540                 


Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn 
545                 550                 555                 560 


Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly 
                565                 570                 575     


Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln 
            580                 585                 590         


Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln 
        595                 600                 605             


Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser 
    610                 615                 620                 


Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr 
625                 630                 635                 640 


Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln 
                645                 650                 655     


Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln 
            660                 665                 670         


Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr 
        675                 680                 685             


Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr 
    690                 695                 700                 


Gln Thr Asn Ser Pro Ala Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr 
705                 710                 715                 720 


Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser 
                725                 730                 735     


Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu 
            740                 745                 750         


Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys 
        755                 760                 765             


Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
    770                 775                 780                 


Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp 
785                 790                 795                 800 


Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr 
                805                 810                 815     


Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
            820                 825                 830         


Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe 
        835                 840                 845             


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp 
    850                 855                 860                 


Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
865                 870                 875                 880 


Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala 
                885                 890                 895     


Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr 
            900                 905                 910         


Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
        915                 920                 925             


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
    930                 935                 940                 


Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln 
945                 950                 955                 960 


Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val 
                965                 970                 975     


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
            980                 985                 990         


Ser Asn Phe Gly Ala Ile Ser Ser  Val Leu Asn Asp Ile  Leu Ser Arg 
        995                 1000                 1005             


Leu Asp  Pro Pro Glu Ala Glu  Val Gln Ile Asp Arg  Leu Ile Thr 
    1010                 1015                 1020             


Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val Thr Gln  Gln Leu Ile 
    1025                 1030                 1035             


Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn Leu Ala  Ala Thr Lys 
    1040                 1045                 1050             


Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys Arg Val  Asp Phe Cys 
    1055                 1060                 1065             


Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro Gln Ser  Ala Pro His 
    1070                 1075                 1080             


Gly Val  Val Phe Leu His Val  Thr Tyr Val Pro Ala  Gln Glu Lys 
    1085                 1090                 1095             


Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His Asp Gly  Lys Ala His 
    1100                 1105                 1110             


Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn Gly Thr  His Trp Phe 
    1115                 1120                 1125             


Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln Ile Ile  Thr Thr Asp 
    1130                 1135                 1140             


Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val Val Ile  Gly Ile Val 
    1145                 1150                 1155             


Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro Glu Leu  Asp Ser Phe 
    1160                 1165                 1170             


Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn His Thr  Ser Pro Asp 
    1175                 1180                 1185             


Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn Ala Ser  Val Val Asn 
    1190                 1195                 1200             


Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu Val Ala  Lys Asn Leu 
    1205                 1210                 1215             


Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu Gly Lys  Tyr Glu Gln 
    1220                 1225                 1230             


Tyr Ile  Lys Trp Pro Ser Gly  Arg Leu Val Pro Arg  Gly Ser Pro 
    1235                 1240                 1245             


Gly Ser  Gly Tyr Ile Pro Glu  Ala Pro Arg Asp Gly  Gln Ala Tyr 
    1250                 1255                 1260             


Val Arg  Lys Asp Gly Glu Trp  Val Leu Leu Ser Thr  Phe Leu Gly 
    1265                 1270                 1275             


His His  His His His His 
    1280                 


<210>  3
<211>  5501
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
rbdgtcgaca ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc       60

atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac      120

cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa      180

tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag      240

tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc      300

ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct      360

acgtattagt catcgctatt accatggtcg aggtgagccc cacgttctgc ttcactctcc      420

ccatctcccc cccctcccca cccccaattt tgtatttatt tattttttaa ttattttgtg      480

cagcgatggg ggcggggggg gggggggcgc gcgccaggcg gggcggggcg gggcgagggg      540

cggggcgggg cgaggcggag aggtgcggcg gcagccaatc agagcggcgc gctccgaaag      600

tttcctttta tggcgaggcg gcggcggcgg cggccctata aaaagcgaag cgcgcggcgg      660

gcgggagtcg ctgcgcgcgc tgccttcgcc ccgtgccccg ctccgcgccg cctcgcgccg      720

cccgccccgg ctctgactga ccgcgttact cccacaggtg agcgggcggg acggcccttc      780

tcctccgggc tgtaattagc gcttggttta atgacggctt gtttcttttc tgtggctgcg      840

tgaaagcctt gaggggctcc gggagggccc tttgtgcggg ggggagcggc tcggggggtg      900

cgtgcgtgtg tgtgtgcgtg gggagcgccg cgtgcggctc cgcgctgccc ggcggctgtg      960

agcgctgcgg gcgcggcgcg gggctttgtg cgctccgcag tgtgcgcgag gggagcgcgg     1020

ccgggggcgg tgccccgcgg tgcggggggg gctgcgaggg gaacaaaggc tgcgtgcggg     1080

gtgtgtgcgt gggggggtga gcagggggtg tgggcgcgtc ggtcgggctg caaccccccc     1140

ctgcaccccc ctccccgagt tgctgagcac ggcccggctt cgggtgcggg gctccgtacg     1200

gggcgtggcg cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg ggtgccgggc     1260

ggggcggggc cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg cccccggagc     1320

gccggcggct gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag     1380

agggcgcagg gacttccttt gtcccaaatc tggcggagcc gaaatctggg aggcgccgcc     1440

gcaccccctc tagcgggcgc ggggcgaagc ggtgcggcgc cggcaggaag gaaatgggcg     1500

gggagggcct tcgtgcgtcg ccgcgccgcc gtccccttct ccctctccag cctcggggct     1560

gccgcggggg gacggctgcc ttcggggggg acggggcagg gcggggttcg gcttctggcg     1620

tgtgaccggc ggctctagag cctctgctaa ccatgttcat gccttcttct ttttcctaca     1680

gctcctgggc aacgtgctgg ttattgtgct gtctcatcat tttggcaaag gccaccatgt     1740

tcgtgtttct ggtgctgctg cctctggtgt ccagccagcg ggtgcagccc accgaatcca     1800

tcgtgcggtt ccccaatatc accaatctgt gccccttcgg cgaggtgttc aatgccacca     1860

gattcgcctc tgtgtacgcc tggaaccgga agcggatcag caattgcgtg gccgactact     1920

ccgtgctgta caactccgcc agcttcagca ccttcaagtg ctacggcgtg tcccctacca     1980

agctgaacga cctgtgcttc acaaacgtgt acgccgacag cttcgtgatc cggggagatg     2040

aagtgcggca gattgcccct ggacagacag gcaagatcgc cgactacaac tacaagctgc     2100

ccgacgactt caccggctgt gtgattgcct ggaacagcaa caacctggac tccaaagtcg     2160

gcggcaacta caattacctg taccggctgt tccggaagtc caatctgaag cccttcgagc     2220

gggacatctc caccgagatc tatcaggccg gcagcacccc ttgtaacggc gtggaaggct     2280

tcaactgcta cttcccactg cagtcctacg gctttcagcc cacaaatggc gtgggctatc     2340

agccctacag agtggtggtg ctgagcttcg aactgctgca tgcccctgcc acagtgtgcg     2400

gccctaagaa aagcaccaat ctcgtgaaga acaaatgcgt gaacttccac catcaccatc     2460

accattgata aaattcgagc tcgcggccgc atcgatctta agtcgcgact cgagctagca     2520

gatctttttc cctctgccaa aaattatggg gacatcatga agccccttga gcatctgact     2580

tctggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt tttgtgtctc     2640

tcactcggaa ggacatatgg gagggcaaat catttaaaac atcagaatga gtatttggtt     2700

tagagtttgg caacatatgc ccatatgctg gctgccatga acaaaggttg gctataaaga     2760

ggtcatcagt atatgaaaca gccccctgct gtccattcct tattccatag aaaagccttg     2820

acttgaggtt agattttttt tatattttgt tttgtgttat ttttttcttt aacatcccta     2880

aaattttcct tacatgtttt actagccaga tttttcctcc tctcctgact actcccagtc     2940

atagctgtcc ctcttctctt atggagatcc ctcgacctgc agcccaagct tggcgtaatc     3000

atggtcatag ctgtttcctg tgtgaaattg ttatccgctc acaattccac acaacatacg     3060

agccggaagc ataaagtgta aagcctgggg tgcctaatga gtgagctaac tcacattaat     3120

tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg tcgtgccagc ggatccgcat     3180

ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg     3240

cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc     3300

gaggccgcct cggcctctga gctattccag aagtagtgag gaggcttttt tggaggccta     3360

ggcttttgca aaaagctaac ttgtttattg cagcttataa tggttacaaa taaagcaata     3420

gcatcacaaa tttcacaaat aaagcatttt tttcactgca ttctagttgt ggtttgtcca     3480

aactcatcaa tgtatcttat catgtctgga tccgctgcat taatgaatcg gccaacgcgc     3540

ggggagaggc ggtttgcgta ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg     3600

ctcggtcgtt cggctgcggc gagcggtatc agctcactca aaggcggtaa tacggttatc     3660

cacagaatca ggggataacg caggaaagaa catgtgagca aaaggccagc aaaaggccag     3720

gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg ctccgccccc ctgacgagca     3780

tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg acaggactat aaagatacca     3840

ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg     3900

atacctgtcc gcctttctcc cttcgggaag cgtggcgctt tctcatagct cacgctgtag     3960

gtatctcagt tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt     4020

tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc cggtaagaca     4080

cgacttatcg ccactggcag cagccactgg taacaggatt agcagagcga ggtatgtagg     4140

cggtgctaca gagttcttga agtggtggcc taactacggc tacactagaa gaacagtatt     4200

tggtatctgc gctctgctga agccagttac cttcggaaaa agagttggta gctcttgatc     4260

cggcaaacaa accaccgctg gtagcggtgg tttttttgtt tgcaagcagc agattacgcg     4320

cagaaaaaaa ggatctcaag aagatccttt gatcttttct acggggtctg acgctcagtg     4380

gaacgaaaac tcacgttaag ggattttggt catgagatta tcaaaaagga tcttcaccta     4440

gatcctttta aattaaaaat gaagttttaa atcaatctaa agtatatatg agtaaacttg     4500

gtctgacagt taccaatgct taatcagtga ggcacctatc tcagcgatct gtctatttcg     4560

ttcatccata gttgcctgac tccccgtcgt gtagataact acgatacggg agggcttacc     4620

atctggcccc agtgctgcaa tgataccgcg agacccacgc tcaccggctc cagatttatc     4680

agcaataaac cagccagccg gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc     4740

ctccatccag tctattaatt gttgccggga agctagagta agtagttcgc cagttaatag     4800

tttgcgcaac gttgttgcca ttgctacagg catcgtggtg tcacgctcgt cgtttggtat     4860

ggcttcattc agctccggtt cccaacgatc aaggcgagtt acatgatccc ccatgttgtg     4920

caaaaaagcg gttagctcct tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt     4980

gttatcactc atggttatgg cagcactgca taattctctt actgtcatgc catccgtaag     5040

atgcttttct gtgactggtg agtactcaac caagtcattc tgagaatagt gtatgcggcg     5100

accgagttgc tcttgcccgg cgtcaatacg ggataatacc gcgccacata gcagaacttt     5160

aaaagtgctc atcattggaa aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct     5220

gttgagatcc agttcgatgt aacccactcg tgcacccaac tgatcttcag catcttttac     5280

tttcaccagc gtttctgggt gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat     5340

aagggcgaca cggaaatgtt gaatactcat actcttcctt tttcaatatt attgaagcat     5400

ttatcagggt tattgtctca tgagcggata catatttgaa tgtatttaga aaaataaaca     5460

aataggggtt ccgcgcacat ttccccgaaa agtgccacct g                         5501


<210>  4
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Met Phe Met Pro Ser Ser Phe Ser Tyr Ser Ser Trp Ala Thr Cys Trp 
1               5                   10                  15      


Leu Leu Cys Cys Leu Ile Ile Leu Ala Lys Ala Thr Met Phe Val Phe 
            20                  25                  30          


Leu Val Leu Leu Pro Leu Val Ser Ser Gln Arg Val Gln Pro Thr Glu 
        35                  40                  45              


Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu 
    50                  55                  60                  


Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys 
65                  70                  75                  80  


Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala 
                85                  90                  95      


Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn 
            100                 105                 110         


Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly 
        115                 120                 125             


Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp 
    130                 135                 140                 


Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp 
145                 150                 155                 160 


Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu 
                165                 170                 175     


Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile 
            180                 185                 190         


Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu 
        195                 200                 205             


Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr 
    210                 215                 220                 


Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu 
225                 230                 235                 240 


Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn 
                245                 250                 255     


Leu Val Lys Asn Lys Cys Val Asn Phe His His His His His His 
            260                 265                 270     


<210>  5
<211>  691
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
    530                 535                 540                 


Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr 
545                 550                 555                 560 


Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
                565                 570                 575     


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
            580                 585                 590         


Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro 
        595                 600                 605             


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
    610                 615                 620                 


Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala 
625                 630                 635                 640 


Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
                645                 650                 655     


Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg His His 
            660                 665                 670         


His His His His Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
        675                 680                 685             


Trp His Glu 
    690     


<210>  6
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val 
1               5                   10              


<210>  7
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
tcgtcgtttt gtcgttttgt cgtt                                              24


<210>  8
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8
tgactgtgaa cgttcgagat ga                                                22


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
tccatgacgt tcctgacgtt                                                   20


<210>  10
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe His 
    210                 215                 220                 


His His His His His 
225                 


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  18-O-Dimethoxytritylhexaethyleneglycol,1-[(2-cyanoethyl)-(N,N-dii
       sopropyl)]-phosphoramidite (Spacer18)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  18-O-Dimethoxytritylhexaethyleneglycol,1-[(2-cyanoethyl)-(N,N-dii
       sopropyl)]-phosphoramidite (Spacer18)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Cholesterol

<400>  11
tccatgacgt tcctgacgtt                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  1-[3-(4-monomethoxytrityloxy)propyl]-1'-[3-[(2-cyanoethyl)-(N,N- 
       diisopropylphosphoramidityl]propyl]-3,3,3',3'-tetramethylindodica
       rbocyanine chloride (Cy5)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  18-O-Dimethoxytritylhexaethyleneglycol,1-[(2-cyanoethyl)-(N,N-dii
       sopropyl)]-phosphoramidite (Spacer18)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  18-O-Dimethoxytritylhexaethyleneglycol,1-[(2-cyanoethyl)-(N,N-dii
       sopropyl)]-phosphoramidite (Spacer18)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Cholesterol

<400>  12
tccatgacgt tcctgacgtt                                                   20


<210>  13
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  18-O-Dimethoxytritylhexaethyleneglycol,1-[(2-cyanoethyl)-(N,N-dii
       sopropyl)]-phosphoramidite (Spacer18)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  18-O-Dimethoxytritylhexaethyleneglycol,1-[(2-cyanoethyl)-(N,N-dii
       sopropyl)]-phosphoramidite (Spacer18)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Cholesterol

<400>  13
tcgtcgtttt gtcgttttgt cgtt                                              24


<210>  14
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  SARS-CoV-2 surface glycoprotein

<400>  14

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  15
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  SARS-CoV-2 RBD

<400>  15

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
    210                 215                 220             


<210>  16
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  SARS-CoV-2 Omicron variant RBD

<400>  16

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Asp Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Leu Ala Pro Phe Phe Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Lys Leu Asp Ser Lys Val Ser 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Asn Lys 
145                 150                 155                 160 


Pro Cys Asn Gly Val Ala Gly Phe Asn Cys Tyr Phe Pro Leu Arg Ser 
                165                 170                 175     


Tyr Ser Phe Arg Pro Thr Tyr Gly Val Gly His Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
    210                 215                 220             


<210>  17
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  RBD

<400>  17

Val Ile Val Arg Glu Gly Ala Gly Thr Ser Phe Val Pro Asn Leu Ala 
1               5                   10                  15      


Glu Pro Lys Ser Gly Arg Arg Arg Arg Thr Pro Ser Ser Gly Arg Gly 
            20                  25                  30          


Ala Lys Arg Cys Gly Ala Gly Arg Lys Glu Met Gly Gly Glu Gly Leu 
        35                  40                  45              


Arg Ala Ser Pro Arg Arg Arg Pro Leu Leu Pro Leu Gln Pro Arg Gly 
    50                  55                  60                  


Cys Arg Gly Gly Thr Ala Ala Phe Gly Gly Asp Gly Ala Gly Arg Gly 
65                  70                  75                  80  


Ser Ala Ser Gly Val Pro Ala Ala Leu Glu Pro Leu Leu Thr Met Phe 
                85                  90                  95      


Met Pro Ser Ser Phe Ser Tyr Ser Ser Trp Ala Thr Cys Trp Leu Leu 
            100                 105                 110         


Cys Cys Leu Ile Ile Leu Ala Lys Ala Thr Met Phe Val Phe Leu Val 
        115                 120                 125             


Leu Leu Pro Leu Val Ser Ser Gln Arg Val Gln Pro Thr Glu Ser Ile 
    130                 135                 140                 


Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe 
145                 150                 155                 160 


Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile 
                165                 170                 175     


Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe 
            180                 185                 190         


Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu 
        195                 200                 205             


Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu 
    210                 215                 220                 


Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn 
225                 230                 235                 240 


Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser 
                245                 250                 255     


Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg 
            260                 265                 270         


Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr 
        275                 280                 285             


Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe 
    290                 295                 300                 


Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly 
305                 310                 315                 320 


Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
                325                 330                 335     


His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val 
            340                 345                 350         


Lys Asn Lys Cys Val Asn Phe 
        355                 


