                         SEQUENCE LISTING

<110>  B.G. Negev Technologies & Applications Ltd., at Ben-Gurion 
       University
       ELKABETS, Moshe
       PORGADOR, Angel
 
<120>  REPORTER CELLS EXPRESSING CHIMERIC POLYPEPTIDES FOR USE IN 
       DETERMINING PRESENCE AND OR ACTIVITY OF IMMUNE CHECKPOINT 
       MOLECULES

<130>  90682

<150>  US 63/159,072
<151>  2021-03-10

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker amino acid sequence

<400>  1

Gly Gly Gly Gly Ser 
1               5   


<210>  2
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker amino acid sequence


<220>
<221>  REPEAT
<222>  (6)..(10)
<223>  may be absent

<220>
<221>  REPEAT
<222>  (11)..(15)
<223>  may be absent

<220>
<221>  REPEAT
<222>  (11)..(20)
<223>  may be absent

<400>  2

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  3
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker amino acid sequence

<400>  3

Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   


<210>  4
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker amino acid sequence

<400>  4

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  5
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker amino acid sequence

<400>  5

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  


<210>  6
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker amino acid sequence

<400>  6

Gly Gly Gly Gly Gly Gly Gly Gly 
1               5               


<210>  7
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker amino acid sequence

<400>  7

Gly Gly Gly Gly Gly Gly 
1               5       


<210>  8
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker amino acid sequence


<220>
<221>  REPEAT
<222>  (6)..(10)
<223>  may be absent

<220>
<221>  REPEAT
<222>  (11)..(15)
<223>  may be absent

<400>  8

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15  


<210>  9
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker amino acid sequence


<220>
<221>  REPEAT
<222>  (12)..(16)
<223>  may be absent

<220>
<221>  REPEAT
<222>  (17)..(21)
<223>  may be absent

<220>
<221>  REPEAT
<222>  (22)..(26)
<223>  may be absent

<400>  9

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
            20                  25          


<210>  10
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker amino acid sequence

<400>  10

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10          


<210>  11
<211>  46
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker amino acid sequence

<400>  11

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Glu Ala Ala Ala Lys Ala Leu Glu Ala Glu Ala Ala Ala Lys Glu Ala 
            20                  25                  30          


Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
        35                  40                  45      


<210>  12
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker amino acid sequence

<400>  12

Pro Ala Pro Ala Pro 
1               5   


<210>  13
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker amino acid sequence

<400>  13

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  14
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker amino acid sequence

<400>  14

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr 
1               5                   10                  


<210>  15
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker amino acid sequence

<400>  15

Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 
1               5                   10          


<210>  16
<211>  134
<212>  PRT
<213>  Artificial sequence

<220>
<223>  chimeric polypeptides

<400>  16

Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Ile 
1               5                   10                  15      


Thr Ala Leu Tyr Leu Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala 
            20                  25                  30          


Ala Asn Leu Gln Asp Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
        35                  40                  45              


Arg Arg Glu Glu Tyr Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro 
    50                  55                  60                  


Glu Met Gly Gly Lys Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly Val 
65                  70                  75                  80  


Tyr Asn Ala Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
                85                  90                  95      


Gly Thr Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
            100                 105                 110         


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
        115                 120                 125             


Gln Thr Leu Ala Pro Arg 
    130                 


<210>  17
<211>  405
<212>  DNA
<213>  Artificial sequence

<220>
<223>  chimeric polypeptides nucleic acid sequence

<400>  17
ctctgctact tgctagatgg aatcctcttc atctacggag tcatcatcac agccctgtac       60

ctgagagcaa aattcagcag gagtgcagag actgctgcca acctgcagga ccccaaccag      120

ctctacaatg agctcaatct agggcgaaga gaggaatatg acgtcttgga gaagaagcgg      180

gctcgggacc cagagatggg aggcaaacag cagaggagga ggaaccccca ggaaggcgta      240

tacaatgcac tgcagaaaga caagatggca gaagcctaca gtgagatcgg cacaaaaggc      300

gagaggcgga gaggcaaggg gcacgatggc ctttaccagg gtctcagcac tgccaccaag      360

gacacctatg atgccctgca tatgcagacc ctggcccctc gctaa                      405


<210>  18
<211>  927
<212>  DNA
<213>  Artificial sequence

<220>
<223>  chimeric polypeptides nucleic acid sequence

<400>  18
gaattcatgc agattccgca ggcgccgtgg ccggtggtgt gggcggtgct gcagctgggc       60

tggcgcccgg gctggtttct ggatagcccg gatcgcccgt ggaacccgcc gacctttagc      120

ccggcgctgc tggtggtgac cgaaggcgat aacgcgacct ttacctgcag ctttagcaac      180

accagcgaaa gctttgtgct gaactggtat cgcatgagcc cgagcaacca gaccgataaa      240

ctggcggcgt ttccggaaga tcgcagccag ccgggccagg attgccgctt tcgcgtgacc      300

cagctgccga acggccgcga ttttcatatg agcgtggtgc gcgcgcgccg caacgatagc      360

ggcacctatc tgtgcggcgc gattagcctg gcgccgaaag cgcagattaa agaaagcctg      420

cgcgcggaac tgcgcgtgac cgaacgccgc gcggaagtgc cgaccgcgca tccgagcccg      480

agcccgcgcc cggcgggcca gtttcagacc ggatccctct gctacttgct agatggaatc      540

ctcttcatct acggagtcat catcacagcc ctgtacctga gagcaaaatt cagcaggagt      600

gcagagactg ctgccaacct gcaggacccc aaccagctct acaatgagct caatctaggg      660

cgaagagagg aatatgacgt cttggagaag aagcgggctc gggacccaga gatgggaggc      720

aaacagcaga ggaggaggaa cccccaggaa ggcgtataca atgcactgca gaaagacaag      780

atggcagaag cctacagtga gatcggcaca aaaggcgaga ggcggagagg caaggggcac      840

gatggccttt accagggtct cagcactgcc accaaggaca cctatgatgc cctgcatatg      900

cagaccctgg cccctcgcta atctaga                                          927


<210>  19
<211>  308
<212>  PRT
<213>  Artificial sequence

<220>
<223>  chimeric polypeptides

<400>  19

Glu Phe Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val 
1               5                   10                  15      


Leu Gln Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg 
            20                  25                  30          


Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu 
        35                  40                  45              


Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser 
    50                  55                  60                  


Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys 
65                  70                  75                  80  


Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg 
                85                  90                  95      


Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val 
            100                 105                 110         


Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile 
        115                 120                 125             


Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu 
    130                 135                 140                 


Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro 
145                 150                 155                 160 


Ser Pro Arg Pro Ala Gly Gln Phe Gln Thr Gly Ser Leu Cys Tyr Leu 
                165                 170                 175     


Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Ile Thr Ala Leu Tyr 
            180                 185                 190         


Leu Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln 
        195                 200                 205             


Asp Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
    210                 215                 220                 


Tyr Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly 
225                 230                 235                 240 


Lys Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu 
                245                 250                 255     


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly 
            260                 265                 270         


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
        275                 280                 285             


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Thr Leu Ala 
    290                 295                 300                 


Pro Arg Ser Arg 
305             


<210>  20
<211>  1769
<212>  DNA
<213>  Artificial sequence

<220>
<223>  chimeric polypeptides nucleic acid sequence

<400>  20
gcggccgcat gtgggaggct cagttcctgg gcttgctgtt tctgcagccg ctttgggtgg       60

ctccagtgaa gcctctccag ccaggggctg aggtcccggt ggtgtgggcc caggaggggg      120

ctcctgccca gctcccctgc agccccacaa tccccctcca ggatctcagc cttctgcgaa      180

gagcaggggt cacttggcag catcagccag acagtggccc gcccgctgcc gcccccggcc      240

atcccctggc ccccggccct cacccggcgg cgccctcctc ctgggggccc aggccccgcc      300

gctacacggt gctgagcgtg ggtcccggag gcctgcgcag cgggaggctg cccctgcagc      360

cccgcgtcca gctggatgag cgcggccggc agcgcgggga cttctcgcta tggctgcgcc      420

cagcccggcg cgcggacgcc ggcgagtacc gcgccgcggt gcacctcagg gaccgcgccc      480

tctcctgccg cctccgtctg cgcctgggcc aggcctcgat gactgccagc cccccaggat      540

ctctcagagc ctccgactgg gtcattttga actgctcctt cagccgccct gaccgcccag      600

cctctgtgca ttggttccgg aaccggggcc agggccgagt ccctgtccgg gagtcccccc      660

atcaccactt agcggaaagc ttcctcttcc tgccccaagt cagccccatg gactctgggc      720

cctggggctg catcctcacc tacagagatg gcttcaacgt ctccatcatg tataacctca      780

ctgttctggg tctggagccc ccaactccct tgacagtgta cgctggagca ggttccaggg      840

tggggctgcc ctgccgcctg cctgctggtg tggggacccg gtctttcctc actgccaagt      900

ggactcctcc tgggggaggc cctgacctcc tggtgactgg agacaatggc gactttaccc      960

ttcgactaga ggatgtgagc caggcccagg ctgggaccta cacctgccat atccatctgc     1020

aggaacagca gctcaatgcc actgtcacat tggcaatcat cacagtgact cccaaatcct     1080

ttgggtcacc tgggtccctg gggaagctgc tttgtgaggt gactccagta tctggacaag     1140

aacgctttgt gtggagctct ctggacaccc catcccagag gagtttctca ggaccttggc     1200

tggaggcaca ggaggcccag ctcctttccc agccttggca atgccagctg taccaggggg     1260

agaggcttct tggagcagca gtgtacttca cagagctgtc tagcccaggt gcccaacgct     1320

ctgggagagc cccaggtgcc ctcccagcag gccacctcct ctgctacttg ctagatggaa     1380

tcctcttcat ctacggagtc atcatcacag ccctgtacct gagagcaaaa ttcagcagga     1440

gtgcagagac tgctgccaac ctgcaggacc ccaaccagct ctacaatgag ctcaatctag     1500

ggcgaagaga ggaatatgac gtcttggaga agaagcgggc tcgggaccca gagatgggag     1560

gcaaacagca gaggaggagg aacccccagg aaggcgtata caatgcactg cagaaagaca     1620

agatggcaga agcctacagt gagatcggca caaaaggcga gaggcggaga ggcaaggggc     1680

acgatggcct ttaccagggt ctcagcactg ccaccaagga cacctatgat gccctgcata     1740

tgcagaccct ggcccctcgc taaggatcc                                       1769


<210>  21
<211>  584
<212>  PRT
<213>  Artificial sequence

<220>
<223>  chimeric polypeptides

<400>  21

Met Trp Glu Ala Gln Phe Leu Gly Leu Leu Phe Leu Gln Pro Leu Trp 
1               5                   10                  15      


Val Ala Pro Val Lys Pro Leu Gln Pro Gly Ala Glu Val Pro Val Val 
            20                  25                  30          


Trp Ala Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile 
        35                  40                  45              


Pro Leu Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly Val Thr Trp Gln 
    50                  55                  60                  


His Gln Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro Gly His Pro Leu 
65                  70                  75                  80  


Ala Pro Gly Pro His Pro Ala Ala Pro Ser Ser Trp Gly Pro Arg Pro 
                85                  90                  95      


Arg Arg Tyr Thr Val Leu Ser Val Gly Pro Gly Gly Leu Arg Ser Gly 
            100                 105                 110         


Arg Leu Pro Leu Gln Pro Arg Val Gln Leu Asp Glu Arg Gly Arg Gln 
        115                 120                 125             


Arg Gly Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala 
    130                 135                 140                 


Gly Glu Tyr Arg Ala Ala Val His Leu Arg Asp Arg Ala Leu Ser Cys 
145                 150                 155                 160 


Arg Leu Arg Leu Arg Leu Gly Gln Ala Ser Met Thr Ala Ser Pro Pro 
                165                 170                 175     


Gly Ser Leu Arg Ala Ser Asp Trp Val Ile Leu Asn Cys Ser Phe Ser 
            180                 185                 190         


Arg Pro Asp Arg Pro Ala Ser Val His Trp Phe Arg Asn Arg Gly Gln 
        195                 200                 205             


Gly Arg Val Pro Val Arg Glu Ser Pro His His His Leu Ala Glu Ser 
    210                 215                 220                 


Phe Leu Phe Leu Pro Gln Val Ser Pro Met Asp Ser Gly Pro Trp Gly 
225                 230                 235                 240 


Cys Ile Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser Ile Met Tyr Asn 
                245                 250                 255     


Leu Thr Val Leu Gly Leu Glu Pro Pro Thr Pro Leu Thr Val Tyr Ala 
            260                 265                 270         


Gly Ala Gly Ser Arg Val Gly Leu Pro Cys Arg Leu Pro Ala Gly Val 
        275                 280                 285             


Gly Thr Arg Ser Phe Leu Thr Ala Lys Trp Thr Pro Pro Gly Gly Gly 
    290                 295                 300                 


Pro Asp Leu Leu Val Thr Gly Asp Asn Gly Asp Phe Thr Leu Arg Leu 
305                 310                 315                 320 


Glu Asp Val Ser Gln Ala Gln Ala Gly Thr Tyr Thr Cys His Ile His 
                325                 330                 335     


Leu Gln Glu Gln Gln Leu Asn Ala Thr Val Thr Leu Ala Ile Ile Thr 
            340                 345                 350         


Val Thr Pro Lys Ser Phe Gly Ser Pro Gly Ser Leu Gly Lys Leu Leu 
        355                 360                 365             


Cys Glu Val Thr Pro Val Ser Gly Gln Glu Arg Phe Val Trp Ser Ser 
    370                 375                 380                 


Leu Asp Thr Pro Ser Gln Arg Ser Phe Ser Gly Pro Trp Leu Glu Ala 
385                 390                 395                 400 


Gln Glu Ala Gln Leu Leu Ser Gln Pro Trp Gln Cys Gln Leu Tyr Gln 
                405                 410                 415     


Gly Glu Arg Leu Leu Gly Ala Ala Val Tyr Phe Thr Glu Leu Ser Ser 
            420                 425                 430         


Pro Gly Ala Gln Arg Ser Gly Arg Ala Pro Gly Ala Leu Pro Ala Gly 
        435                 440                 445             


His Leu Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val 
    450                 455                 460                 


Ile Ile Thr Ala Leu Tyr Leu Arg Ala Lys Phe Ser Arg Ser Ala Glu 
465                 470                 475                 480 


Thr Ala Ala Asn Leu Gln Asp Pro Asn Gln Leu Tyr Asn Glu Leu Asn 
                485                 490                 495     


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Glu Lys Lys Arg Ala Arg 
            500                 505                 510         


Asp Pro Glu Met Gly Gly Lys Gln Gln Arg Arg Arg Asn Pro Gln Glu 
        515                 520                 525             


Gly Val Tyr Asn Ala Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
    530                 535                 540                 


Glu Ile Gly Thr Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
545                 550                 555                 560 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
                565                 570                 575     


His Met Gln Thr Leu Ala Pro Arg 
            580                 


<210>  22
<211>  1025
<212>  DNA
<213>  Artificial sequence

<220>
<223>  chimeric polypeptides nucleic acid sequence

<400>  22
gcggccgcat gttttcacat cttccctttg actgtgtcct gctgctgctg ctgctactac       60

ttacaaggtc ctcagaagtg gaatacagag cggaggtcgg tcagaatgcc tatctgccct      120

gcttctacac cccagccgcc ccagggaacc tcgtgcccgt ctgctggggc aaaggagcct      180

gtcctgtgtt tgaatgtggc aacgtggtgc tcaggactga tgaaagggat gtgaattatt      240

ggacatccag atactggcta aatggggatt tccgcaaagg agatgtgtcc ctgaccatag      300

agaatgtgat tctagcagac agtgggatct actgctgccg aatccaaatc ccaggcataa      360

tgaatgatga aaaatttaac ctgaagttgg tcatcaaacc agccaaggtc acccctgcac      420

cgactctgca gagagacttc actgcagcct ttccaaggat gcttaccacc aggggacatg      480

gcccagcaga gacacagaca ctggggagcc tccctgatat aaatctaaca caaatatcca      540

cattggccaa tgagttacgg gactctagat tggccaatga cttacgggac tctggagcaa      600

ccatcagaat aggcctctgc tacttgctag atggaatcct cttcatctac ggagtcatca      660

tcacagccct gtacctgaga gcaaaattca gcaggagtgc agagactgct gccaacctgc      720

aggaccccaa ccagctctac aatgagctca atctagggcg aagagaggaa tatgacgtct      780

tggagaagaa gcgggctcgg gacccagaga tgggaggcaa acagcagagg aggaggaacc      840

cccaggaagg cgtatacaat gcactgcaga aagacaagat ggcagaagcc tacagtgaga      900

tcggcacaaa aggcgagagg cggagaggca aggggcacga tggcctttac cagggtctca      960

gcactgccac caaggacacc tatgatgccc tgcatatgca gaccctggcc cctcgctaag     1020

gatcc                                                                 1025


<210>  23
<211>  336
<212>  PRT
<213>  Artificial sequence

<220>
<223>  chimeric polypeptides

<400>  23

Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu 
        35                  40                  45              


Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly 
    50                  55                  60                  


Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser 
65                  70                  75                  80  


Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr 
                85                  90                  95      


Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile 
            100                 105                 110         


Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val 
        115                 120                 125             


Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe 
    130                 135                 140                 


Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala 
145                 150                 155                 160 


Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile 
                165                 170                 175     


Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu 
            180                 185                 190         


Arg Asp Ser Gly Ala Thr Ile Arg Ile Gly Leu Cys Tyr Leu Leu Asp 
        195                 200                 205             


Gly Ile Leu Phe Ile Tyr Gly Val Ile Ile Thr Ala Leu Tyr Leu Arg 
    210                 215                 220                 


Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp Pro 
225                 230                 235                 240 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                245                 250                 255     


Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys Gln 
            260                 265                 270         


Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln Lys 
        275                 280                 285             


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu Arg 
    290                 295                 300                 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
305                 310                 315                 320 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Thr Leu Ala Pro Arg 
                325                 330                 335     


<210>  24
<211>  902
<212>  DNA
<213>  Artificial sequence

<220>
<223>  chimeric polypeptides nucleic acid sequence

<400>  24
gcggccgcat ggcttgcctt ggatttcagc ggcacaaggc tcagctgaac ctggctacca       60

ggacctggcc ctgcactctc ctgttttttc ttctcttcat ccctgtcttc tgcaaagcaa      120

tgcacgtggc ccagcctgct gtggtactgg ccagcagccg aggcatcgcc agctttgtgt      180

gtgagtatgc atctccaggc aaagccactg aggtccgggt gacagtgctt cggcaggctg      240

acagccaggt gactgaagtc tgtgcggcaa cctacatgat ggggaatgag ttgaccttcc      300

tagatgattc catctgcacg ggcacctcca gtggaaatca agtgaacctc actatccaag      360

gactgagggc catggacacg ggactctaca tctgcaaggt ggagctcatg tacccaccgc      420

catactacct gggcataggc aacggaaccc agatttatgt aattgatcca gaaccgtgcc      480

cagattctga cctctgctac ttgctagatg gaatcctctt catctacgga gtcatcatca      540

cagccctgta cctgagagca aaattcagca ggagtgcaga gactgctgcc aacctgcagg      600

accccaacca gctctacaat gagctcaatc tagggcgaag agaggaatat gacgtcttgg      660

agaagaagcg ggctcgggac ccagagatgg gaggcaaaca gcagaggagg aggaaccccc      720

aggaaggcgt atacaatgca ctgcagaaag acaagatggc agaagcctac agtgagatcg      780

gcacaaaagg cgagaggcgg agaggcaagg ggcacgatgg cctttaccag ggtctcagca      840

ctgccaccaa ggacacctat gatgccctgc atatgcagac cctggcccct cgctaaggat      900

cc                                                                     902


<210>  25
<211>  295
<212>  PRT
<213>  Artificial sequence

<220>
<223>  chimeric polypeptides

<400>  25

Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    50                  55                  60                  


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
65                  70                  75                  80  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
                85                  90                  95      


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
145                 150                 155                 160 


Asp Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile 
                165                 170                 175     


Ile Thr Ala Leu Tyr Leu Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr 
            180                 185                 190         


Ala Ala Asn Leu Gln Asp Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
        195                 200                 205             


Gly Arg Arg Glu Glu Tyr Asp Val Leu Glu Lys Lys Arg Ala Arg Asp 
    210                 215                 220                 


Pro Glu Met Gly Gly Lys Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly 
225                 230                 235                 240 


Val Tyr Asn Ala Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                245                 250                 255     


Ile Gly Thr Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            260                 265                 270         


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
        275                 280                 285             


Met Gln Thr Leu Ala Pro Arg 
    290                 295 


<210>  26
<211>  842
<212>  DNA
<213>  Artificial sequence

<220>
<223>  chimeric polypeptides nucleic acid sequence

<400>  26
gcggccgcat gcgctggtgt ctcctcctga tctgggccca ggggctgagg caggctcccc       60

tcgcctcagg aatgatgaca ggcacaatag aaacaacggg gaacatttct gcagagaaag      120

gtggctctat catcttacaa tgtcacctct cctccaccac ggcacaagtg acccaggtca      180

actgggagca gcaggaccag cttctggcca tttgtaatgc tgacttgggg tggcacatct      240

ccccatcctt caaggatcga gtggccccag gtcccggcct gggcctcacc ctccagtcgc      300

tgaccgtgaa cgatacaggg gagtacttct gcatctatca cacctaccct gatgggacgt      360

acactgggag aatcttcctg gaggtcctag aaagctcagt ggctgagcac ggtgccaggt      420

tccagattcc actctgctac ttgctagatg gaatcctctt catctacgga gtcatcatca      480

cagccctgta cctgagagca aaattcagca ggagtgcaga gactgctgcc aacctgcagg      540

accccaacca gctctacaat gagctcaatc tagggcgaag agaggaatat gacgtcttgg      600

agaagaagcg ggctcgggac ccagagatgg gaggcaaaca gcagaggagg aggaaccccc      660

aggaaggcgt atacaatgca ctgcagaaag acaagatggc agaagcctac agtgagatcg      720

gcacaaaagg cgagaggcgg agaggcaagg ggcacgatgg cctttaccag ggtctcagca      780

ctgccaccaa ggacacctat gatgccctgc atatgcagac cctggcccct cgctaaggat      840

cc                                                                     842


<210>  27
<211>  275
<212>  PRT
<213>  Artificial sequence

<220>
<223>  chimeric polypeptides

<400>  27

Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu Arg Gln Ala 
1               5                   10                  15      


Pro Leu Ala Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn 
            20                  25                  30          


Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser 
        35                  40                  45              


Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln 
    50                  55                  60                  


Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser 
65                  70                  75                  80  


Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln 
                85                  90                  95      


Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr 
            100                 105                 110         


Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu 
        115                 120                 125             


Ser Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro Leu Cys Tyr 
    130                 135                 140                 


Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Ile Thr Ala Leu 
145                 150                 155                 160 


Tyr Leu Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu 
                165                 170                 175     


Gln Asp Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
            180                 185                 190         


Glu Tyr Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met Gly 
        195                 200                 205             


Gly Lys Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala 
    210                 215                 220                 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys 
225                 230                 235                 240 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
                245                 250                 255     


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Thr Leu 
            260                 265                 270         


Ala Pro Arg 
        275 


<210>  28
<211>  1442
<212>  DNA
<213>  Artificial sequence

<220>
<223>  chimeric polypeptides nucleic acid sequence

<400>  28
gcggccgcat gaaaagccag acccaggtgt ttgtgtttct gctgctgtgc gtgagcggcg       60

cgcatggcag cattgtgatg acccagaccc cgaaatttct gctggtgagc gcgggcgatc      120

gcgtgaccat tacctgcaaa gcgagccaga gcgtgagcaa cgatgtggcg tggtatcagc      180

agaaaccggg ccagagcccg aaactgctga tttattatgc gagcaaccgc tataccggcg      240

tgccggatcg ctttaccggc agcggctatg gcaccgattt tacctttacc attagcaccg      300

tgcaggcgga agatctggcg gtgtattttt gccagcagga ttatagcagc ccgccgtgga      360

cctttggcgg cggcaccaaa ctggaaattg gcggcggcgg cagcggcggc ggcggcagcg      420

gcggcggcgg cagcggcggc ggcggcagcc aggtgcagct gaaacagagc ggcccgggcc      480

tggtgcagcc gagccagagc ctgagcctga cctgcaccgt gagcggcttt agcctgacca      540

gctatggcgt gcattgggtg cgccagccgc cgggcaaagg cctggaatgg ctgggcgtga      600

tttggagcgg cggcagcacc gattataacg cggcgtttat tagccgcctg agcattcgca      660

aagataacag caaaagccag gtgtttttta aaatgaacag cctgcaggcg gatgataccg      720

cgatttatta ttgcgcgcgc acctttacca ccagcaccag cgcgtggttt gcgtattggg      780

gccagggcac cctggtgacc gtgagcgcgg tcgacgaaca gaaactgatt agcgaagaag      840

atctggcgct gagcaacagc attatgtatt ttagccattt tgtgccggtg tttctgccgg      900

cgaaaccgac caccaccccg gcgccgcgcc cgccgacccc ggcgccgacc attgcgagcc      960

agccgctgag cctgcgcccg gaagcgagcc gcccggcggc gggcggcgcg gtgcataccc     1020

gcggcctgga tctctgctac ttgctagatg gaatcctctt catctacgga gtcatcatca     1080

cagccctgta cctgagagca aaattcagca ggagtgcaga gactgctgcc aacctgcagg     1140

accccaacca gctctacaat gagctcaatc tagggcgaag agaggaatat gacgtcttgg     1200

agaagaagcg ggctcgggac ccagagatgg gaggcaaaca gcagaggagg aggaaccccc     1260

aggaaggcgt atacaatgca ctgcagaaag acaagatggc agaagcctac agtgagatcg     1320

gcacaaaagg cgagaggcgg agaggcaagg ggcacgatgg cctttaccag ggtctcagca     1380

ctgccaccaa ggacacctat gatgccctgc atatgcagac cctggcccct cgctaaggat     1440

cc                                                                    1442


<210>  29
<211>  288
<212>  PRT
<213>  homo sapiens

<400>  29

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  30
<211>  525
<212>  PRT
<213>  homo sapiens

<400>  30

Met Trp Glu Ala Gln Phe Leu Gly Leu Leu Phe Leu Gln Pro Leu Trp 
1               5                   10                  15      


Val Ala Pro Val Lys Pro Leu Gln Pro Gly Ala Glu Val Pro Val Val 
            20                  25                  30          


Trp Ala Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile 
        35                  40                  45              


Pro Leu Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly Val Thr Trp Gln 
    50                  55                  60                  


His Gln Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro Gly His Pro Leu 
65                  70                  75                  80  


Ala Pro Gly Pro His Pro Ala Ala Pro Ser Ser Trp Gly Pro Arg Pro 
                85                  90                  95      


Arg Arg Tyr Thr Val Leu Ser Val Gly Pro Gly Gly Leu Arg Ser Gly 
            100                 105                 110         


Arg Leu Pro Leu Gln Pro Arg Val Gln Leu Asp Glu Arg Gly Arg Gln 
        115                 120                 125             


Arg Gly Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala 
    130                 135                 140                 


Gly Glu Tyr Arg Ala Ala Val His Leu Arg Asp Arg Ala Leu Ser Cys 
145                 150                 155                 160 


Arg Leu Arg Leu Arg Leu Gly Gln Ala Ser Met Thr Ala Ser Pro Pro 
                165                 170                 175     


Gly Ser Leu Arg Ala Ser Asp Trp Val Ile Leu Asn Cys Ser Phe Ser 
            180                 185                 190         


Arg Pro Asp Arg Pro Ala Ser Val His Trp Phe Arg Asn Arg Gly Gln 
        195                 200                 205             


Gly Arg Val Pro Val Arg Glu Ser Pro His His His Leu Ala Glu Ser 
    210                 215                 220                 


Phe Leu Phe Leu Pro Gln Val Ser Pro Met Asp Ser Gly Pro Trp Gly 
225                 230                 235                 240 


Cys Ile Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser Ile Met Tyr Asn 
                245                 250                 255     


Leu Thr Val Leu Gly Leu Glu Pro Pro Thr Pro Leu Thr Val Tyr Ala 
            260                 265                 270         


Gly Ala Gly Ser Arg Val Gly Leu Pro Cys Arg Leu Pro Ala Gly Val 
        275                 280                 285             


Gly Thr Arg Ser Phe Leu Thr Ala Lys Trp Thr Pro Pro Gly Gly Gly 
    290                 295                 300                 


Pro Asp Leu Leu Val Thr Gly Asp Asn Gly Asp Phe Thr Leu Arg Leu 
305                 310                 315                 320 


Glu Asp Val Ser Gln Ala Gln Ala Gly Thr Tyr Thr Cys His Ile His 
                325                 330                 335     


Leu Gln Glu Gln Gln Leu Asn Ala Thr Val Thr Leu Ala Ile Ile Thr 
            340                 345                 350         


Val Thr Pro Lys Ser Phe Gly Ser Pro Gly Ser Leu Gly Lys Leu Leu 
        355                 360                 365             


Cys Glu Val Thr Pro Val Ser Gly Gln Glu Arg Phe Val Trp Ser Ser 
    370                 375                 380                 


Leu Asp Thr Pro Ser Gln Arg Ser Phe Ser Gly Pro Trp Leu Glu Ala 
385                 390                 395                 400 


Gln Glu Ala Gln Leu Leu Ser Gln Pro Trp Gln Cys Gln Leu Tyr Gln 
                405                 410                 415     


Gly Glu Arg Leu Leu Gly Ala Ala Val Tyr Phe Thr Glu Leu Ser Ser 
            420                 425                 430         


Pro Gly Ala Gln Arg Ser Gly Arg Ala Pro Gly Ala Leu Pro Ala Gly 
        435                 440                 445             


His Leu Leu Leu Phe Leu Thr Leu Gly Val Leu Ser Leu Leu Leu Leu 
    450                 455                 460                 


Val Thr Gly Ala Phe Gly Phe His Leu Trp Arg Arg Gln Trp Arg Pro 
465                 470                 475                 480 


Arg Arg Phe Ser Ala Leu Glu Gln Gly Ile His Pro Pro Gln Ala Gln 
                485                 490                 495     


Ser Lys Ile Glu Glu Leu Glu Gln Glu Pro Glu Pro Glu Pro Glu Pro 
            500                 505                 510         


Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Gln Leu 
        515                 520                 525 


<210>  31
<211>  301
<212>  PRT
<213>  homo sapiens

<400>  31

Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu 
        35                  40                  45              


Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly 
    50                  55                  60                  


Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser 
65                  70                  75                  80  


Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr 
                85                  90                  95      


Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile 
            100                 105                 110         


Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val 
        115                 120                 125             


Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Leu Gln Arg Asp Phe 
    130                 135                 140                 


Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala 
145                 150                 155                 160 


Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile 
                165                 170                 175     


Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu 
            180                 185                 190         


Arg Asp Ser Gly Ala Thr Ile Arg Ile Gly Ile Tyr Ile Gly Ala Gly 
        195                 200                 205             


Ile Cys Ala Gly Leu Ala Leu Ala Leu Ile Phe Gly Ala Leu Ile Phe 
    210                 215                 220                 


Lys Trp Tyr Ser His Ser Lys Glu Lys Ile Gln Asn Leu Ser Leu Ile 
225                 230                 235                 240 


Ser Leu Ala Asn Leu Pro Pro Ser Gly Leu Ala Asn Ala Val Ala Glu 
                245                 250                 255     


Gly Ile Arg Ser Glu Glu Asn Ile Tyr Thr Ile Glu Glu Asn Val Tyr 
            260                 265                 270         


Glu Val Glu Glu Pro Asn Glu Tyr Tyr Cys Tyr Val Ser Ser Arg Gln 
        275                 280                 285             


Gln Pro Ser Gln Pro Leu Gly Cys Arg Phe Ala Met Pro 
    290                 295                 300     


<210>  32
<211>  223
<212>  PRT
<213>  homo sapiens

<400>  32

Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    50                  55                  60                  


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
65                  70                  75                  80  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
                85                  90                  95      


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
145                 150                 155                 160 


Asp Phe Leu Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe 
                165                 170                 175     


Tyr Ser Phe Leu Leu Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys 
            180                 185                 190         


Arg Ser Pro Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu 
        195                 200                 205             


Pro Glu Cys Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
    210                 215                 220             


<210>  33
<211>  244
<212>  PRT
<213>  homo sapiens

<400>  33

Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu Arg Gln Ala 
1               5                   10                  15      


Pro Leu Ala Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn 
            20                  25                  30          


Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser 
        35                  40                  45              


Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln 
    50                  55                  60                  


Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser 
65                  70                  75                  80  


Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln 
                85                  90                  95      


Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr 
            100                 105                 110         


Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu 
        115                 120                 125             


Ser Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro Leu Leu Gly 
    130                 135                 140                 


Ala Met Ala Ala Thr Leu Val Val Ile Cys Thr Ala Val Ile Val Val 
145                 150                 155                 160 


Val Ala Leu Thr Arg Lys Lys Lys Ala Leu Arg Ile His Ser Val Glu 
                165                 170                 175     


Gly Asp Leu Arg Arg Lys Ser Ala Gly Gln Glu Glu Trp Ser Pro Ser 
            180                 185                 190         


Ala Pro Ser Pro Pro Gly Ser Cys Val Gln Ala Glu Ala Ala Pro Ala 
        195                 200                 205             


Gly Leu Cys Gly Glu Gln Arg Gly Glu Asp Cys Ala Glu Leu His Asp 
    210                 215                 220                 


Tyr Phe Asn Val Leu Ser Tyr Arg Ser Leu Gly Asn Cys Ser Phe Phe 
225                 230                 235                 240 


Thr Glu Thr Gly 
                


<210>  34
<211>  289
<212>  PRT
<213>  homo sapiens

<400>  34

Met Lys Thr Leu Pro Ala Met Leu Gly Thr Gly Lys Leu Phe Trp Val 
1               5                   10                  15      


Phe Phe Leu Ile Pro Tyr Leu Asp Ile Trp Asn Ile His Gly Lys Glu 
            20                  25                  30          


Ser Cys Asp Val Gln Leu Tyr Ile Lys Arg Gln Ser Glu His Ser Ile 
        35                  40                  45              


Leu Ala Gly Asp Pro Phe Glu Leu Glu Cys Pro Val Lys Tyr Cys Ala 
    50                  55                  60                  


Asn Arg Pro His Val Thr Trp Cys Lys Leu Asn Gly Thr Thr Cys Val 
65                  70                  75                  80  


Lys Leu Glu Asp Arg Gln Thr Ser Trp Lys Glu Glu Lys Asn Ile Ser 
                85                  90                  95      


Phe Phe Ile Leu His Phe Glu Pro Met Leu Pro Asn Asp Asn Gly Ser 
            100                 105                 110         


Tyr Arg Cys Ser Ala Asn Phe Gln Ser Asn Leu Ile Glu Ser His Ser 
        115                 120                 125             


Thr Thr Leu Tyr Val Thr Asp Val Lys Gly Ala Ser Glu Arg Pro Ser 
    130                 135                 140                 


Lys Asp Glu Val Ala Ser Arg Pro Trp Leu Leu Tyr Ser Leu Leu Pro 
145                 150                 155                 160 


Leu Gly Gly Leu Pro Leu Leu Ile Thr Thr Trp Phe Cys Leu Phe Cys 
                165                 170                 175     


Cys Leu Arg Arg His Gln Gly Lys Gln Asn Glu Leu Ser Asp Thr Ala 
            180                 185                 190         


Gly Arg Glu Ile Asn Leu Val Asp Ala His Leu Lys Ser Glu Gln Thr 
        195                 200                 205             


Glu Ala Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu Ala Gly 
    210                 215                 220                 


Ile Tyr Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln Glu Gly Ser 
225                 230                 235                 240 


Glu Val Cys Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly Ile Val 
                245                 250                 255     


Tyr Ala Ser Leu Asn His Ser Val Ile Gly Leu Asn Ser Arg Leu Ala 
            260                 265                 270         


Arg Asn Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys Val Arg 
        275                 280                 285             


Ser 
    


<210>  35
<211>  569
<212>  PRT
<213>  homo sapiens

<400>  35

Met Glu Lys Lys Trp Lys Tyr Cys Ala Val Tyr Tyr Ile Ile Gln Ile 
1               5                   10                  15      


His Phe Val Lys Gly Val Trp Glu Lys Thr Val Asn Thr Glu Glu Asn 
            20                  25                  30          


Val Tyr Ala Thr Leu Gly Ser Asp Val Asn Leu Thr Cys Gln Thr Gln 
        35                  40                  45              


Thr Val Gly Phe Phe Val Gln Met Gln Trp Ser Lys Val Thr Asn Lys 
    50                  55                  60                  


Ile Asp Leu Ile Ala Val Tyr His Pro Gln Tyr Gly Phe Tyr Cys Ala 
65                  70                  75                  80  


Tyr Gly Arg Pro Cys Glu Ser Leu Val Thr Phe Thr Glu Thr Pro Glu 
                85                  90                  95      


Asn Gly Ser Lys Trp Thr Leu His Leu Arg Asn Met Ser Cys Ser Val 
            100                 105                 110         


Ser Gly Arg Tyr Glu Cys Met Leu Val Leu Tyr Pro Glu Gly Ile Gln 
        115                 120                 125             


Thr Lys Ile Tyr Asn Leu Leu Ile Gln Thr His Val Thr Ala Asp Glu 
    130                 135                 140                 


Trp Asn Ser Asn His Thr Ile Glu Ile Glu Ile Asn Gln Thr Leu Glu 
145                 150                 155                 160 


Ile Pro Cys Phe Gln Asn Ser Ser Ser Lys Ile Ser Ser Glu Phe Thr 
                165                 170                 175     


Tyr Ala Trp Ser Val Glu Asp Asn Gly Thr Gln Glu Thr Leu Ile Ser 
            180                 185                 190         


Gln Asn His Leu Ile Ser Asn Ser Thr Leu Leu Lys Asp Arg Val Lys 
        195                 200                 205             


Leu Gly Thr Asp Tyr Arg Leu His Leu Ser Pro Val Gln Ile Phe Asp 
    210                 215                 220                 


Asp Gly Arg Lys Phe Ser Cys His Ile Arg Val Gly Pro Asn Lys Ile 
225                 230                 235                 240 


Leu Arg Ser Ser Thr Thr Val Lys Val Phe Ala Lys Pro Glu Ile Pro 
                245                 250                 255     


Val Ile Val Glu Asn Asn Ser Thr Asp Val Leu Val Glu Arg Arg Phe 
            260                 265                 270         


Thr Cys Leu Leu Lys Asn Val Phe Pro Lys Ala Asn Ile Thr Trp Phe 
        275                 280                 285             


Ile Asp Gly Ser Phe Leu His Asp Glu Lys Glu Gly Ile Tyr Ile Thr 
    290                 295                 300                 


Asn Glu Glu Arg Lys Gly Lys Asp Gly Phe Leu Glu Leu Lys Ser Val 
305                 310                 315                 320 


Leu Thr Arg Val His Ser Asn Lys Pro Ala Gln Ser Asp Asn Leu Thr 
                325                 330                 335     


Ile Trp Cys Met Ala Leu Ser Pro Val Pro Gly Asn Lys Val Trp Asn 
            340                 345                 350         


Ile Ser Ser Glu Lys Ile Thr Phe Leu Leu Gly Ser Glu Ile Ser Ser 
        355                 360                 365             


Thr Asp Pro Pro Leu Ser Val Thr Glu Ser Thr Leu Asp Thr Gln Pro 
    370                 375                 380                 


Ser Pro Ala Ser Ser Val Ser Pro Ala Arg Tyr Pro Ala Thr Ser Ser 
385                 390                 395                 400 


Val Thr Leu Val Asp Val Ser Ala Leu Arg Pro Asn Thr Thr Pro Gln 
                405                 410                 415     


Pro Ser Asn Ser Ser Met Thr Thr Arg Gly Phe Asn Tyr Pro Trp Thr 
            420                 425                 430         


Ser Ser Gly Thr Asp Thr Lys Lys Ser Val Ser Arg Ile Pro Ser Glu 
        435                 440                 445             


Thr Tyr Ser Ser Ser Pro Ser Gly Ala Gly Ser Thr Leu His Asp Asn 
    450                 455                 460                 


Val Phe Thr Ser Thr Ala Arg Ala Phe Ser Glu Val Pro Thr Thr Ala 
465                 470                 475                 480 


Asn Gly Ser Thr Lys Thr Asn His Val His Ile Thr Gly Ile Val Val 
                485                 490                 495     


Asn Lys Pro Lys Asp Gly Met Ser Trp Pro Val Ile Val Ala Ala Leu 
            500                 505                 510         


Leu Phe Cys Cys Met Ile Leu Phe Gly Leu Gly Val Arg Lys Trp Cys 
        515                 520                 525             


Gln Tyr Gln Lys Glu Ile Met Glu Arg Pro Pro Pro Phe Lys Pro Pro 
    530                 535                 540                 


Pro Pro Pro Ile Lys Tyr Thr Cys Ile Gln Glu Pro Asn Glu Ser Asp 
545                 550                 555                 560 


Leu Pro Tyr His Glu Met Glu Thr Leu 
                565                 


<210>  36
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  partial sequence of BTLA

<400>  36

Trp Leu Leu Tyr Arg 
1               5   


