                         SEQUENCE LISTING

<110>  Mabylon AG
       University of Zurich
 
<120>  ANTIBODIES AGAINST TDP-43 AND METHODS OF USING THE SAME

<130>  MA03P002WO1

<160>  114   

<170>  PatentIn version 3.5

<210>  1
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn Asp Glu Pro Ile 
1               5                   10                  15      


Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu Ser Thr Val Thr 
            20                  25                  30          


Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg Asn Pro Val Ser 
        35                  40                  45              


Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile Leu His Ala Pro 
    50                  55                  60                  


Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn Tyr Pro Lys Asp 
65                  70                  75                  80  


Asn Lys Arg Lys Met Asp Glu Thr Asp Ala Ser Ser Ala Val Lys Val 
                85                  90                  95      


Lys Arg Ala Val Gln Lys Thr Ser Asp Leu Ile Val Leu Gly Leu Pro 
            100                 105                 110         


Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr Phe Ser Thr Phe Gly 
        115                 120                 125             


Glu Val Leu Met Val Gln Val Lys Lys Asp Leu Lys Thr Gly His Ser 
    130                 135                 140                 


Lys Gly Phe Gly Phe Val Arg Phe Thr Glu Tyr Glu Thr Gln Val Lys 
145                 150                 155                 160 


Val Met Ser Gln Arg His Met Ile Asp Gly Arg Trp Cys Asp Cys Lys 
                165                 170                 175     


Leu Pro Asn Ser Lys Gln Ser Gln Asp Glu Pro Leu Arg Ser Arg Lys 
            180                 185                 190         


Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu Asp Glu Leu Arg 
        195                 200                 205             


Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val Phe Ile Pro Lys 
    210                 215                 220                 


Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp Asp Gln Ile Ala 
225                 230                 235                 240 


Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly Ile Ser Val His 
                245                 250                 255     


Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg Gln Leu Glu Arg 
            260                 265                 270         


Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn Gln Gly Gly 
        275                 280                 285             


Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn Asn Gln Gly 
    290                 295                 300                 


Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro 
305                 310                 315                 320 


Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met 
                325                 330                 335     


Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn 
            340                 345                 350         


Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly 
        355                 360                 365             


Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly 
    370                 375                 380                 


Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly 
385                 390                 395                 400 


Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met 
                405                 410                 


<210>  2
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TDP-43 peptide

<400>  2

Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly Phe Gly Ser Ser Met 
1               5                   10                  15      


Asp Ser Lys Ser Ser Gly Trp Gly Met 
            20                  25  


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31F3 CDRH1

<400>  3

Gly Tyr Tyr Leu His 
1               5   


<210>  4
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31F3 CDRH2

<400>  4

Arg Ile Asn Pro Gly Ser Gly Gly Thr Lys Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31F3 CDRH3

<400>  5

Tyr Gln Val Tyr Gly Glu Arg Gly Arg Tyr Met Asp Val 
1               5                   10              


<210>  6
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31F3 CDRL1

<400>  6

Thr Gly Thr Ser Ser Asp Val Gly Thr Tyr Asp Leu Val Ser 
1               5                   10                  


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31F3 CDRL2

<400>  7

Glu Asp Asn Lys Arg Pro Ser 
1               5           


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31F3 CDRL3

<400>  8

Cys Ser Tyr Ala Ala Ile Ser Thr Leu Ile 
1               5                   10  


<210>  9
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31F3 VH

<400>  9

Gln Val Gln Leu Glu Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asn Pro Gly Ser Gly Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Val Asn Arg Leu Arg Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Gln Val Tyr Gly Glu Arg Gly Arg Tyr Met Asp Val Trp 
            100                 105                 110         


Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  10
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31F3 VL

<400>  10

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Thr Tyr 
            20                  25                  30          


Asp Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Glu Asp Asn Lys Arg Pro Ser Gly Leu Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Ala Ile 
                85                  90                  95      


Ser Thr Leu Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  11
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31F3 heavy chain

<400>  11

Gln Val Gln Leu Glu Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asn Pro Gly Ser Gly Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Val Asn Arg Leu Arg Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Gln Val Tyr Gly Glu Arg Gly Arg Tyr Met Asp Val Trp 
            100                 105                 110         


Gly Lys Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Thr Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Leu Lys Thr 
    210                 215                 220                 


Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys 
225                 230                 235                 240 


Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser 
                245                 250                 255     


Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys 
            260                 265                 270         


Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala Pro Glu Leu Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn Tyr Asn Thr Thr Pro Pro 
        435                 440                 445             


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Lys 
            


<210>  12
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31F3 light chain

<400>  12

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Thr Tyr 
            20                  25                  30          


Asp Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Glu Asp Asn Lys Arg Pro Ser Gly Leu Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Ala Ile 
                85                  90                  95      


Ser Thr Leu Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  30E3 CDRH1

<400>  13

Asp Tyr Tyr Leu His 
1               5   


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  30E3 CDRH2

<400>  14

Arg Ile Asn Pro Asn Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  15
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  30E3 CDRH3

<400>  15

Val Lys Ile Val Val Leu Arg Ser Thr Pro Thr Leu Tyr Tyr Phe Asp 
1               5                   10                  15      


Tyr 
    


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  30E3 CDRL2

<400>  16

Glu Gly Ser Lys Arg Pro Ser 
1               5           


<210>  17
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  30E3 CDRL3

<400>  17

Cys Ser Tyr Ala Gly Thr Ser Thr Leu Val 
1               5                   10  


<210>  18
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  30E3 VH

<400>  18

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asn Pro Asn Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Ser Val Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Ser Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Val Lys Ile Val Val Leu Arg Ser Thr Pro Thr Leu Tyr Tyr 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  19
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  30E3 VL

<400>  19

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Thr Tyr 
            20                  25                  30          


Asp Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Val 
        35                  40                  45              


Met Ile Tyr Glu Gly Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Thr 
                85                  90                  95      


Ser Thr Leu Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  20
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  30E3 heavy chain

<400>  20

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asn Pro Asn Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Ser Val Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Ser Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Val Lys Ile Val Val Leu Arg Ser Thr Pro Thr Leu Tyr Tyr 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Thr 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
    210                 215                 220                 


Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
225                 230                 235                 240 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
                245                 250                 255     


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala 
            260                 265                 270         


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        275                 280                 285             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    290                 295                 300                 


Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr Val 
305                 310                 315                 320 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                325                 330                 335     


Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            340                 345                 350         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        355                 360                 365             


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro 
    370                 375                 380                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
385                 390                 395                 400 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                405                 410                 415     


Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn Tyr 
            420                 425                 430         


Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        435                 440                 445             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile Phe 
    450                 455                 460                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys 
465                 470                 475                 480 


Ser Leu Ser Leu Ser Pro Gly Lys 
                485             


<210>  21
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  30E3 light chain

<400>  21

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Thr Tyr 
            20                  25                  30          


Asp Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Val 
        35                  40                  45              


Met Ile Tyr Glu Gly Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Thr 
                85                  90                  95      


Ser Thr Leu Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  22
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9F11 CDRH2

<400>  22

Arg Ile Asn Pro Lys Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  23
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9F11 CDRH3

<400>  23

Val Lys Ile Val Val Val Arg Ser Thr Pro Thr Leu Tyr Tyr Leu Asp 
1               5                   10                  15      


Tyr 
    


<210>  24
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9F11 CDRL1

<400>  24

Thr Gly Ser Ser Ser Asp Val Gly Thr Tyr Asp Leu Val Ser 
1               5                   10                  


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9F11 CDRL2

<400>  25

Glu Gly His Lys Arg Pro Ser 
1               5           


<210>  26
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9F11 VH

<400>  26

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asn Pro Lys Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Val Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Lys Ile Val Val Val Arg Ser Thr Pro Thr Leu Tyr Tyr 
            100                 105                 110         


Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  27
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9F11 VL

<400>  27

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Ser Ser Ser Asp Val Gly Thr Tyr 
            20                  25                  30          


Asp Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Val 
        35                  40                  45              


Met Ile Tyr Glu Gly His Lys Arg Pro Ser Gly Val Ser Asn Arg Val 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Thr 
                85                  90                  95      


Ser Thr Leu Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  28
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15D7 CDRH1

<400>  28

Asn Tyr Ala Met His 
1               5   


<210>  29
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15D7 CDRH2

<400>  29

Ala Met Ser Ser Asn Gly Gly Ser Thr Tyr Tyr Gly Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  30
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15D7 CDRH3

<400>  30

Arg Gly Arg Lys Ala Pro Ser Leu Tyr Tyr Phe Asp Cys 
1               5                   10              


<210>  31
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15D7 CDRL1

<400>  31

Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 
1               5                   10      


<210>  32
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15D7 CDRL2

<400>  32

Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210>  33
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15D7 CDRL3

<400>  33

Gln Gln Tyr Asn Asn Trp Pro Pro Trp Thr 
1               5                   10  


<210>  34
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15D7 VH

<400>  34

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Gly Asn Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ser Ala Met Ser Ser Asn Gly Gly Ser Thr Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Thr Arg Gly Arg Lys Ala Pro Ser Leu Tyr Tyr Phe Asp Cys Trp 
            100                 105                 110         


Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  35
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15D7 VL

<400>  35

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  36
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  36

Arg Ile Asn Pro Asn Ala Gly Asn Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  37
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  37

Arg Ile Asn Pro Lys Ala Gly Asn Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  38
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  38

Arg Ile Asn Pro Asn Ser Gly Asn Val Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  39
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  39

Arg Ile Asn Pro Asn Ser Gly Asn Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  40
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  40

Arg Ile Asn Pro Lys Ser Gly Asn Val Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  41
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  41

Arg Ile Asn Pro Lys Ser Gly Asn Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  42
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  42

Arg Ile Asn Pro Gly Ser Gly Gly Thr Arg Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  43
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  43

Arg Ile Asn Pro Gly Ser Gly Gly Thr Gln Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  44
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  44

Arg Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  45
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  45

Arg Ile Asn Pro Gly Ser Gly Gly Thr Lys Tyr Ala Gln Arg Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  46
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  46

Arg Ile Asn Pro Gly Ser Gly Gly Thr Lys Tyr Ala Gln Gln Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  47
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  47

Arg Ile Asn Pro Asn Ser Gly Asn Thr Asn Tyr Ala Gln Arg Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  48
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  48

Arg Ile Asn Pro Asn Ser Gly Asn Thr Asn Tyr Ala Gln Gln Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  49
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  49

Arg Ile Asn Pro Lys Ser Gly Asn Thr Asn Tyr Ala Gln Arg Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  50
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  50

Arg Ile Asn Pro Lys Ser Gly Asn Thr Asn Tyr Ala Gln Gln Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  51
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3

<400>  51

Val Arg Ile Val Val Leu Arg Ser Thr Pro Thr Leu Tyr Tyr Phe Asp 
1               5                   10                  15      


Tyr 
    


<210>  52
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3

<400>  52

Val Arg Ile Val Val Val Arg Ser Thr Pro Thr Leu Tyr Tyr Leu Asp 
1               5                   10                  15      


Tyr 
    


<210>  53
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2

<400>  53

Glu Leu Asn Lys Arg Pro Ser 
1               5           


<210>  54
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2

<400>  54

Glu Gln Asn Lys Arg Pro Ser 
1               5           


<210>  55
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2

<400>  55

Glu Ala Asn Lys Arg Pro Ser 
1               5           


<210>  56
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2

<400>  56

Glu Asp Asn Arg Arg Pro Ser 
1               5           


<210>  57
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2

<400>  57

Glu Asp Asn Gln Arg Pro Ser 
1               5           


<210>  58
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2

<400>  58

Glu Gly Ser Arg Arg Pro Ser 
1               5           


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2

<400>  59

Glu Gly Ser Gln Arg Pro Ser 
1               5           


<210>  60
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2

<400>  60

Glu Gly His Arg Arg Pro Ser 
1               5           


<210>  61
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2

<400>  61

Glu Gly His Gln Arg Pro Ser 
1               5           


<210>  62
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  62

Ser Ser Tyr Ala Ala Ile Ser Thr Leu Ile 
1               5                   10  


<210>  63
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  63

Ser Ser Tyr Ala Gly Thr Ser Thr Leu Val 
1               5                   10  


<210>  64
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  64

Gln Ser Tyr Ala Ala Ile Ser Thr Leu Ile 
1               5                   10  


<210>  65
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  65

Gln Ser Tyr Ala Gly Thr Ser Thr Leu Val 
1               5                   10  


<210>  66
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  66

Gly Ser Tyr Ala Ala Ile Ser Thr Leu Ile 
1               5                   10  


<210>  67
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  67

Gly Ser Tyr Ala Gly Thr Ser Thr Leu Val 
1               5                   10  


<210>  68
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain CH1-CH2-CH3

<400>  68

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  69
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lambda light chain CL

<400>  69

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  70
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  kappa light chain CL

<400>  70

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  71
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker motif

<400>  71

Gly Gly Gly Gly Ser 
1               5   


<210>  72
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  retention peptide

<400>  72

Lys Asp Glu Leu 
1               


<210>  73
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization sequence

<400>  73

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  74
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  s3Flag

<400>  74

Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr 
1               5                   10                  15      


Lys Asp Asp Asp Asp Lys 
            20          


<210>  75
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA tag

<400>  75

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  76
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  31F3 CDRH1

<400>  76
ggctactatt tacac                                                        15


<210>  77
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  31F3 CDRH2

<400>  77
cggatcaacc ctggcagtgg tggcacaaag tatgcacaga agtttcaggg c                51


<210>  78
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  31F3 CDRH3

<400>  78
taccaagtgt acggtgagcg cgggaggtac atggacgtc                              39


<210>  79
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  31F3 CDRL1

<400>  79
actggaacca gcagtgatgt tgggacttat gaccttgtct cc                          42


<210>  80
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31F3 CDRL2

<400>  80

Gly Ala Ala Gly Ala Cys Ala Ala Thr Ala Ala Gly Cys Gly Gly Cys 
1               5                   10                  15      


Cys Cys Thr Cys Ala 
            20      


<210>  81
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  31F3 CDRL3

<400>  81
tgctcatatg ctgctattag cactttaata                                        30


<210>  82
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  31F3 VH

<400>  82
caggtgcagc tggtgcagtc tggggctgag gtgaagaaac ctggggcctc agtgaaggtc       60

tcctgcaaga cttctggata caccttcacc gactactatt tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggacgg atcaacccta acagtggtaa cacaaactat      180

gcacagaagt ttcagggccg ggtcagcgtg accagggaca cgtccatcag cacagcctac      240

atggagctga gcaggctgag ctctgacgac acggccgtgt atttctgtgc gagagttaag      300

atagtagttc taaggagcac gccaacgctc tactactttg actactgggg ccagggaacc      360

ctggtcaccg tgtcctca                                                    378


<210>  83
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  31F3 VL

<400>  83
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgatgttggg acttatgacc ttgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatcatt tatgaagaca ataagcggcc ctcagggctt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgacgat ctctgggctc      240

caggctgacg acgaggctga ttattactgc tgctcatatg ctgctattag cactttaata      300

ttcggcggag ggaccaaggt gaccgtccta                                       330


<210>  84
<211>  1624
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  31F3 heavy chain


<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  n is a, c, g, or t

<400>  84
tatcctggnn gagggcatgg ggaatcttct tntngggggc ggcagncaca cgagcgcact       60

cccaggtgca gctggagcag tctggggctg aggtgaagag gcctggggcc tcagtgaagg      120

tctcctgcaa ggcttctgga tacaccttca ccggctacta tttacactgg gtgcgacagg      180

cccctggaca aggacttgag tggatgggac ggatcaaccc tggcagtggt ggcacaaagt      240

atgcacagaa gtttcagggc agggtcagca tgacccggga cacgtccatc agcacagcct      300

atatggaggt gaacagactg agacctgacg acacggccgt gtattattgt gcgagatacc      360

aagtgtacgg tgagcgcggg aggtacatgg acgtctgggg caaagggacc acggtcaccg      420

tctcgtcagc ttccaccaag ggcccatcgg tcttccccct ggcgccctgc tccaggagca      480

cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc gaaccggtga      540

cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg gctgtcctac      600

agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc agcttgggca      660

cccagaccta cacctgcaac gtgaatcaca agcccagcaa caccaaggtg gacaagagag      720

ttgagctcaa aaccccactt ggtgacacaa ctcacacatg cccacggtgc ccagagccca      780

aatcttgtga cacacctccc ccgtgcccac ggtgcccaga gcccaaatct tgtgacacac      840

ctcccccatg cccacggtgc ccagagccca aatcttgtga cacacctccc ccatgcccac      900

ggtgcccagc acctgaactc ctgggaggac cgtcagtctt cctcttcccc ccaaaaccca      960

aggataccct tatgatttcc cggacccctg aggtcacgtg cgtggtggtg gacgtgagcc     1020

acgaagaccc cgaggtccag ttcaagtggt acgtggacgg cgtggaggtg cataatgcca     1080

agacaaagcc gcgggaggag cagttcaaca gcacgttccg tgtggtcagc gtcctcaccg     1140

tcctgcacca ggactggctg aacggcaagg agtacaagtg caaggtctcc aacaaagccc     1200

tcccagcccc catcgagaaa accatctcca aaaccaaagg acagccccga gaaccacagg     1260

tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc ctgacctgcc     1320

tggtcaaagg cttctacccc agcgacatcg ccgtggagtg ggagagcagc gggcagccgg     1380

agaacaacta caacaccacg cctcccatgc tggactccga cggctccttc ttcctctaca     1440

gcaagctcac cgtggacaag agcaggtggc agcaggggaa catcttctca tgctccgtga     1500

tgcatgaggc tctgcacaac cgcttcacgc agaagagcct ctccctgtct ccgggtaaat     1560

gagtgcgacg gccggcaagc ccccgctccc cgggctctcg gggtcgcgcg aggatgcttg     1620

gcac                                                                  1624


<210>  85
<211>  715
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  31F3 light chain


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is a, c, g, or t

<400>  85
acctcnggca cagggtcctg ggcccagtct gccctgactc agcctgcctc cgtgtctggg       60

tctcctggac agtcgatcac catctcctgc actggaacca gcagtgatgt tgggacttat      120

gaccttgtct cctggtacca acagcaccca ggcaaagccc ccaaactcat catttatgaa      180

gacaataagc ggccctcagg gctttctaat cgcttctctg gctccaagtc tggcaacacg      240

gcctccctga cgatctctgg gctccaggct gacgacgagg ctgattatta ctgctgctca      300

tatgctgcta ttagcacttt aatattcggc ggagggacca aggtgaccgt cctaggtcag      360

cccaaggctg ccccctcggt cactctgttc ccgccctcct ctgaggagct tcaagccaac      420

aaggccacac tggtgtgtct cataagtgac ttctacccgg gagccgtgac agtggcctgg      480

aaggcagata gcagccccgt caaggcggga gtggagacca ccacaccctc caaacaaagc      540

aacaacaagt acgcggccag cagctatctg agcctgacgc ctgagcagtg gaagtcccac      600

agaagctaca gctgccaggt cacgcatgaa gggagcaccg tggagaagac agtggcccct      660

acagaatgtt cataggttct aaaccctcac cccccccacg ggagactaga gctga           715


<210>  86
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  30E3 CDRH1

<400>  86
gactactatt tacac                                                        15


<210>  87
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  30E3 CDRH2

<400>  87
cggatcaacc ctaacagtgg taacacaaac tatgcacaga agtttcaggg c                51


<210>  88
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  30E3 CDRH3

<400>  88
gttaagatag tagttctaag gagcacgcca acgctctact actttgacta c                51


<210>  89
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  30E3 CDRL1

<400>  89
actggaacca gcagtgatgt tgggacttat gaccttgtct cc                          42


<210>  90
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  30E3 CDRL2

<400>  90
gagggcagta agcggccctc a                                                 21


<210>  91
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  30E3 CDRL3

<400>  91
tgctcatatg caggtactag caccttggtg                                        30


<210>  92
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  30E3 VH

<400>  92
caggtgcagc tggtgcagtc tggggctgag gtgaagaaac ctggggcctc agtgaaggtc       60

tcctgcaaga cttctggata caccttcacc gactactatt tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggacgg atcaacccta acagtggtaa cacaaactat      180

gcacagaagt ttcagggccg ggtcagcgtg accagggaca cgtccatcag cacagcctac      240

atggagctga gcaggctgag ctctgacgac acggccgtgt atttctgtgc gagagttaag      300

atagtagttc taaggagcac gccaacgctc tactactttg actactgggg ccagggaacc      360

ctggtcaccg tgtcctca                                                    378


<210>  93
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  30E3 VL

<400>  93
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgatgttggg acttatgacc ttgtctcctg gtaccaacaa      120

catccaggca aagcccccaa agtcatgatt tatgagggca gtaagcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgacaat ctccggactc      240

caggctgagg acgaggctga ttattactgc tgctcatatg caggtactag caccttggtg      300

ttcggcggag ggaccaaggt gaccgtccta                                       330


<210>  94
<211>  1570
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  30E3 heavy chain

<400>  94
atcctcttct tggtggcagc agccacagga gcccactccc aggtgcagct ggtgcagtct       60

ggggctgagg tgaagaaacc tggggcctca gtgaaggtct cctgcaagac ttctggatac      120

accttcaccg actactattt acactgggtg cgacaggccc ctggacaagg gcttgagtgg      180

atgggacgga tcaaccctaa cagtggtaac acaaactatg cacagaagtt tcagggccgg      240

gtcagcgtga ccagggacac gtccatcagc acagcctaca tggagctgag caggctgagc      300

tctgacgaca cggccgtgta tttctgtgcg agagttaaga tagtagttct aaggagcacg      360

ccaacgctct actactttga ctactggggc cagggaaccc tggtcaccgt gtcctcagct      420

tccaccaagg gcccatcggt cttccccctg gcgccctgct ccaggagcac ctctgggggc      480

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      540

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      600

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac      660

acctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagctcaaa      720

accccacttg gtgacacaac tcacacatgc ccacggtgcc cagagcccaa atcttgtgac      780

acacctcccc cgtgcccacg gtgcccagag cccaaatctt gtgacacacc tcccccatgc      840

ccacggtgcc cagcacctga actcctggga ggaccgtcag tcttcctctt ccccccaaaa      900

cccaaggata cccttatgat ttcccggacc cctgaggtca cgtgcgtggt ggtggacgtg      960

agccacgaag accccgaggt ccagttcaag tggtacgtgg acggcgtgga ggtgcataat     1020

gccaagacaa agccgcggga ggagcagttc aacagcacgt tccgtgtggt cagcgtcctc     1080

accgtcctgc accaggactg gctgaacggc aaggagtaca agtgcaaggt ctccaacaaa     1140

gccctcccag cccccatcga gaaaaccatc tccaaaacca aaggacagcc ccgagaacca     1200

caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc     1260

tgcctggtca aaggcttcta ccccagcgac atcgccgtgg agtgggagag cagcgggcag     1320

ccggagaaca actacaacac cacgcctccc atgctggact ccgacggctc cttcttcctc     1380

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacatctt ctcatgctcc     1440

gtgatgcatg aggctctgca caaccgcttc acgcagaaga gcctctccct gtctccgggt     1500

aaatgagtgc gacggccggc aagcccccgc tccccgggct ctcggggtcg cgcgaggatg     1560

cttggcacgt                                                            1570


<210>  95
<211>  728
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  30E3 light chain

<400>  95
cactcagggc acagggtcct gggcccagtc tgccctgact cagcctgcct ccgtgtctgg       60

gtctcctgga cagtcgatca ccatctcctg cactggaacc agcagtgatg ttgggactta      120

tgaccttgtc tcctggtacc aacaacatcc aggcaaagcc cccaaagtca tgatttatga      180

gggcagtaag cggccctcag gggtttctaa tcgcttctct ggctccaagt ctggcaacac      240

ggcctccctg acaatctccg gactccaggc tgaggacgag gctgattatt actgctgctc      300

atatgcaggt actagcacct tggtgttcgg cggagggacc aaggtgaccg tcctaggtca      360

gcccaaggct gccccctcgg tcactctgtt cccgccctcc tctgaggagc ttcaagccaa      420

caaggccaca ctggtgtgtc tcataagtga cttctacccg ggagccgtga cagtggcctg      480

gaaggcagat agcagccccg tcaaggcggg agtggagacc accacaccct ccaaacaaag      540

caacaacaag tacgcggcca gcagctacct gagcctgacg cctgagcagt ggaagtccca      600

cagaagctac agctgccagg tcacgcatga agggagcacc gtggagaaga cagtggcccc      660

tacagaatgt tcataggttc tcaaccctca ccccccacca cgggagacta gagctgcagg      720

atcccagg                                                               728


<210>  96
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  9F11 CDRH2

<400>  96
cggatcaacc ctaagagtgg taacacaaac tatgcacaga aatttcaggg c                51


<210>  97
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  9F11 CDRH3

<400>  97
gttaagatag tagtggtaag gagcacgcca accctctact accttgacta c                51


<210>  98
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  9F11 CDRL1

<400>  98
actggatcca gcagtgatgt tgggacttat gaccttgtct cc                          42


<210>  99
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  9F11 CDRL2

<400>  99
gagggccata agcggccctc a                                                 21


<210>  100
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  9F11 VH

<400>  100
caggtgcagc tggtgcagtc tggggctgag gtgaagaaac ctggggcctc agtgaaggtc       60

tcctgcaaga cttctggata caccttcacc gactactatt tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggacgg atcaacccta agagtggtaa cacaaactat      180

gcacagaaat ttcagggccg ggtcaccgtg accagggaca cgtccatcag cacagcctac      240

atggagctga gcaggttgag atctgacgac acggccgtgt attattgtgc gagagttaag      300

atagtagtgg taaggagcac gccaaccctc tactaccttg actactgggg ccagggaacc      360

ctggtcaccg tgtcctca                                                    378


<210>  101
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  9F11 VL

<400>  101
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gatccagcag tgatgttggg acttatgacc ttgtctcctg gtaccaacag      120

cacccaggca aagcccccaa ggtcatgatt tatgagggcc ataagcggcc ctcaggggtt      180

tctaatcgcg tctctggctc caagtctggc aacacggcct ccctgacaat ctccgggctc      240

caggctgagg acgaggctga ttattactgc tgctcatatg caggtactag caccttggtg      300

ttcggcggag ggaccaaggt gaccgtccta                                       330


<210>  102
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  15D7 CDRH1

<400>  102
aactatgcta tgcac                                                        15


<210>  103
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  15D7 CDRH2

<400>  103
gctatgagta gtaatggggg tagcacatac tacggagact ccgtgaaggg c                51


<210>  104
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  15D7 CDRH3

<400>  104
cggggtagaa aggcgccttc gctttactac tttgactgc                              39


<210>  105
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  15D7 CDRL1

<400>  105
agggccagtc agagtgttag cagcaactta gcc                                    33


<210>  106
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  15D7 CDRL2

<400>  106
ggtgcatcca ccagggccac c                                                 21


<210>  107
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  15D7 CDRL3

<400>  107
cagcagtata ataactggcc tccgtggacc                                        30


<210>  108
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  15D7 VH

<400>  108
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgttcag cctctggatt caccttcggt aactatgcta tgcactgggt ccgccaggct      120

ccagggaagg gactggaata tgtttcagct atgagtagta atgggggtag cacatactac      180

ggagactccg tgaagggcag attcaccatc tccagagaca attccaagaa cacgttgtat      240

cttcaaatga gcagtctgag agctgaggac acggctgttt attactgtgt gacgcggggt      300

agaaaggcgc cttcgcttta ctactttgac tgctggggcc cgggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  109
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  15D7 VL

<400>  109
gaaattgtgt tgacacagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccaccgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag tataataact ggcctccgtg gaccttcggc      300

caagggacac gactggagat taaa                                             324


<210>  110
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TDP-43 variant

<400>  110

Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn Asp Glu Pro Ile 
1               5                   10                  15      


Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu Ser Thr Val Thr 
            20                  25                  30          


Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg Asn Pro Val Ser 
        35                  40                  45              


Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile Leu His Ala Pro 
    50                  55                  60                  


Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn Tyr Pro Lys Asp 
65                  70                  75                  80  


Asn Lys Arg Lys Met Asp Glu Thr Asp Ala Ser Ser Ala Val Lys Val 
                85                  90                  95      


Lys Arg Ala Val Gln Lys Thr Ser Asp Leu Ile Val Leu Gly Leu Pro 
            100                 105                 110         


Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr Phe Ser Thr Phe Gly 
        115                 120                 125             


Glu Val Leu Met Val Gln Val Lys Lys Asp Leu Lys Thr Gly His Ser 
    130                 135                 140                 


Lys Gly Phe Gly Phe Val Arg Phe Thr Glu Tyr Glu Thr Gln Val Lys 
145                 150                 155                 160 


Val Met Ser Gln Arg His Met Ile Asp Gly Arg Trp Cys Asp Cys Lys 
                165                 170                 175     


Leu Pro Asn Ser Lys Gln Ser Gln Asp Glu Pro Leu Arg Ser Lys Val 
            180                 185                 190         


Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu Asp Glu Leu Arg Glu 
        195                 200                 205             


Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val Phe Ile Pro Lys Pro 
    210                 215                 220                 


Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp Asp Gln Ile Ala Gln 
225                 230                 235                 240 


Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly Ile Ser Val His Ile 
                245                 250                 255     


Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg Gln Leu Glu Arg Ser 
            260                 265                 270         


Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn Gln Gly Gly Phe 
        275                 280                 285             


Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn Asn Gln Gly Ser 
    290                 295                 300                 


Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro Ala 
305                 310                 315                 320 


Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met Met 
                325                 330                 335     


Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn Asn 
            340                 345                 350         


Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly Ser 
        355                 360                 365             


Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly Trp 
    370                 375                 380                 


Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly Phe 
385                 390                 395                 400 


Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met 
                405                 410             


<210>  111
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31F3 Hf VH

<400>  111

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asn Pro Gly Ser Gly Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Gln Val Tyr Gly Glu Arg Gly Arg Tyr Met Asp Val Trp 
            100                 105                 110         


Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  112
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31F3 Lf VL

<400>  112

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Thr Tyr 
            20                  25                  30          


Asp Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Asp Asn Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Ala Ile 
                85                  90                  95      


Ser Thr Leu Ile Phe Gly Ser Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  113
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31F3 Hg VH

<400>  113

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asn Pro Gly Ser Gly Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Gln Val Tyr Gly Glu Arg Gly Arg Tyr Met Asp Val Trp 
            100                 105                 110         


Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  114
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31F3 Lg VL

<400>  114

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Thr Tyr 
            20                  25                  30          


Asp Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Glu Asp Asn Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Ala Ile 
                85                  90                  95      


Ser Thr Leu Ile Phe Gly Ser Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


