                         SEQUENCE LISTING

<110>  Ustav organicke chemie a biochemie AV CR, v. v. i.
 
<120>  3'3' CYCLIC DINUCLEOTIDES CONTAINING ISONUCLEOTIDIC UNITS

<130>  P

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  75
<212>  DNA
<213>  artificial

<220>
<223>  synthetic oligonucleotide

<400>  1
aaagatcttg gaaagtgaaa ccttggaaaa cgaaactgga caaagggaaa ctgcagaaac       60

tgaaacaaag cttaa                                                        75


<210>  2
<211>  75
<212>  DNA
<213>  artificial

<220>
<223>  synthetic oligonucleotide

<400>  2
ttaagctttg tttcagtttc tgcagtttcc ctttgtccag tttcgttttc caaggtttca       60

ctttccaaga tcttt                                                        75


<210>  3
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  3
tgcttgctca actctacgtc                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  4
gtggtttgtc caaactcatc                                                   20


<210>  5
<211>  31
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  5
gtgggatccg ccccagctga gatctctgca g                                      31


<210>  6
<211>  38
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  6
tatgcggccg cctattacac agtaacctct tccttttc                               38


<210>  7
<211>  330
<212>  DNA
<213>  artificial

<220>
<223>  DNA sequence of 8-His-SUMO

<400>  7
atgtcgcatc accatcatca tcaccaccat gggatgtcgg actcagaagt caatcaagaa       60

gctaagccag aggtcaagcc agaagtcaag cctgagactc acatcaattt aaaggtgtcc      120

gatggatctt cagagatctt cttcaagatc aaaaagacca ctcctttaag aaggctgatg      180

gaagcgttcg ctaaaagaca gggtaaggaa atggactcct taagattctt gtacgacggt      240

attagaattc aagctgatca gacccctgaa gatttggaca tggaggataa cgatattatt      300

gaggctcacc gcgaacagat tggtggatcc                                       330


<210>  8
<211>  110
<212>  PRT
<213>  artificial

<220>
<223>  Amino acid sequence of 8-His-SUMO

<400>  8

Met Ser His His His His His His His His Gly Met Ser Asp Ser Glu 
1               5                   10                  15      


Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro Glu Val Lys Pro Glu 
            20                  25                  30          


Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser Ser Glu Ile Phe Phe 
        35                  40                  45              


Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu Met Glu Ala Phe Ala 
    50                  55                  60                  


Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Arg Phe Leu Tyr Asp Gly 
65                  70                  75                  80  


Ile Arg Ile Gln Ala Asp Gln Thr Pro Glu Asp Leu Asp Met Glu Asp 
                85                  90                  95      


Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile Gly Gly Ser 
            100                 105                 110 


<210>  9
<211>  204
<212>  PRT
<213>  artificial

<220>
<223>  Amino acid sequence of truncated WT STING

<400>  9

Ala Pro Ala Glu Ile Ser Ala Val Cys Glu Lys Gly Asn Phe Asn Val 
1               5                   10                  15      


Ala His Gly Leu Ala Trp Ser Tyr Tyr Ile Gly Tyr Leu Arg Leu Ile 
            20                  25                  30          


Leu Pro Glu Leu Gln Ala Arg Ile Arg Thr Tyr Asn Gln His Tyr Asn 
        35                  40                  45              


Asn Leu Leu Arg Gly Ala Val Ser Gln Arg Leu Tyr Ile Leu Leu Pro 
    50                  55                  60                  


Leu Asp Cys Gly Val Pro Asp Asn Leu Ser Met Ala Asp Pro Asn Ile 
65                  70                  75                  80  


Arg Phe Leu Asp Lys Leu Pro Gln Gln Thr Gly Asp Arg Ala Gly Ile 
                85                  90                  95      


Lys Asp Arg Val Tyr Ser Asn Ser Ile Tyr Glu Leu Leu Glu Asn Gly 
            100                 105                 110         


Gln Arg Ala Gly Thr Cys Val Leu Glu Tyr Ala Thr Pro Leu Gln Thr 
        115                 120                 125             


Leu Phe Ala Met Ser Gln Tyr Ser Gln Ala Gly Phe Ser Arg Glu Asp 
    130                 135                 140                 


Arg Leu Glu Gln Ala Lys Leu Phe Cys Arg Thr Leu Glu Asp Ile Leu 
145                 150                 155                 160 


Ala Asp Ala Pro Glu Ser Gln Asn Asn Cys Arg Leu Ile Ala Tyr Gln 
                165                 170                 175     


Glu Pro Ala Asp Asp Ser Ser Phe Ser Leu Ser Gln Glu Val Leu Arg 
            180                 185                 190         


His Leu Arg Gln Glu Glu Lys Glu Glu Val Thr Val 
        195                 200                 


<210>  10
<211>  204
<212>  PRT
<213>  artificial

<220>
<223>  Amino acid sequence of truncated AQ STING

<400>  10

Ala Pro Ala Glu Ile Ser Ala Val Cys Glu Lys Gly Asn Phe Asn Val 
1               5                   10                  15      


Ala His Gly Leu Ala Trp Ser Tyr Tyr Ile Gly Tyr Leu Arg Leu Ile 
            20                  25                  30          


Leu Pro Glu Leu Gln Ala Arg Ile Arg Thr Tyr Asn Gln His Tyr Asn 
        35                  40                  45              


Asn Leu Leu Arg Gly Ala Val Ser Gln Arg Leu Tyr Ile Leu Leu Pro 
    50                  55                  60                  


Leu Asp Cys Gly Val Pro Asp Asn Leu Ser Met Ala Asp Pro Asn Ile 
65                  70                  75                  80  


Arg Phe Leu Asp Lys Leu Pro Gln Gln Thr Ala Asp Arg Ala Gly Ile 
                85                  90                  95      


Lys Asp Arg Val Tyr Ser Asn Ser Ile Tyr Glu Leu Leu Glu Asn Gly 
            100                 105                 110         


Gln Arg Ala Gly Thr Cys Val Leu Glu Tyr Ala Thr Pro Leu Gln Thr 
        115                 120                 125             


Leu Phe Ala Met Ser Gln Tyr Ser Gln Ala Gly Phe Ser Arg Glu Asp 
    130                 135                 140                 


Arg Leu Glu Gln Ala Lys Leu Phe Cys Gln Thr Leu Glu Asp Ile Leu 
145                 150                 155                 160 


Ala Asp Ala Pro Glu Ser Gln Asn Asn Cys Arg Leu Ile Ala Tyr Gln 
                165                 170                 175     


Glu Pro Ala Asp Asp Ser Ser Phe Ser Leu Ser Gln Glu Val Leu Arg 
            180                 185                 190         


His Leu Arg Gln Glu Glu Lys Glu Glu Val Thr Val 
        195                 200                 


<210>  11
<211>  392
<212>  PRT
<213>  artificial

<220>
<223>  Murine cGAS amino acid sequence including pelB leader and His-tag

<400>  11

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Met Pro Asp Lys Leu Lys Lys Val Leu Asp 
            20                  25                  30          


Lys Leu Arg Leu Lys Arg Lys Asp Ile Ser Glu Ala Ala Glu Thr Val 
        35                  40                  45              


Asn Lys Val Val Glu Arg Leu Leu Arg Arg Met Gln Lys Arg Glu Ser 
    50                  55                  60                  


Glu Phe Lys Gly Val Glu Gln Leu Asn Thr Gly Ser Tyr Tyr Glu His 
65                  70                  75                  80  


Val Lys Ile Ser Ala Pro Asn Glu Phe Asp Val Met Phe Lys Leu Glu 
                85                  90                  95      


Val Pro Arg Ile Glu Leu Gln Glu Tyr Tyr Glu Thr Gly Ala Phe Tyr 
            100                 105                 110         


Leu Val Lys Phe Lys Arg Ile Pro Arg Gly Asn Pro Leu Ser His Phe 
        115                 120                 125             


Leu Glu Gly Glu Val Leu Ser Ala Thr Lys Met Leu Ser Lys Phe Arg 
    130                 135                 140                 


Lys Ile Ile Lys Glu Glu Val Lys Glu Ile Lys Asp Ile Asp Val Ser 
145                 150                 155                 160 


Val Glu Lys Glu Lys Pro Gly Ser Pro Ala Val Thr Leu Leu Ile Arg 
                165                 170                 175     


Asn Pro Glu Glu Ile Ser Val Asp Ile Ile Leu Ala Leu Glu Ser Lys 
            180                 185                 190         


Gly Ser Trp Pro Ile Ser Thr Lys Glu Gly Leu Pro Ile Gln Gly Trp 
        195                 200                 205             


Leu Gly Thr Lys Val Arg Thr Asn Leu Arg Arg Glu Pro Phe Tyr Leu 
    210                 215                 220                 


Val Pro Lys Asn Ala Lys Asp Gly Asn Ser Phe Gln Gly Glu Thr Trp 
225                 230                 235                 240 


Arg Leu Ser Phe Ser His Thr Glu Lys Tyr Ile Leu Asn Asn His Gly 
                245                 250                 255     


Ile Glu Lys Thr Cys Cys Glu Ser Ser Gly Ala Lys Cys Cys Arg Lys 
            260                 265                 270         


Glu Cys Leu Lys Leu Met Lys Tyr Leu Leu Glu Gln Leu Lys Lys Glu 
        275                 280                 285             


Phe Gln Glu Leu Asp Ala Phe Cys Ser Tyr His Val Lys Thr Ala Ile 
    290                 295                 300                 


Phe His Met Trp Thr Gln Asp Pro Gln Asp Ser Gln Trp Asp Pro Arg 
305                 310                 315                 320 


Asn Leu Ser Ser Cys Phe Asp Lys Leu Leu Ala Phe Phe Leu Glu Cys 
                325                 330                 335     


Leu Arg Thr Glu Lys Leu Asp His Tyr Phe Ile Pro Lys Phe Asn Leu 
            340                 345                 350         


Phe Ser Gln Glu Leu Ile Asp Arg Lys Ser Lys Glu Phe Leu Ser Lys 
        355                 360                 365             


Lys Ile Glu Tyr Glu Arg Asn Asn Gly Phe Pro Ile Phe Asp Lys Leu 
    370                 375                 380                 


Leu Glu His His His His His His 
385                 390         


