                         SEQUENCE LISTING

<110>  Biocytogen Pharmaceuticals (Beijing) Co., Ltd.
 
<120>  GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC 
       SIGLEC15

<130>  1

<150>  CN202110267425.9
<151>  2021-03-12

<150>  CN202110476149.7
<151>  2021-04-29

<160>  57    

<170>  PatentIn version 3.5

<210>  1
<211>  342
<212>  PRT
<213>  Mus musculus

<400>  1

Met Glu Gly Ser Leu Gln Leu Leu Ala Cys Leu Ala Cys Val Leu Gln 
1               5                   10                  15      


Met Gly Ser Leu Val Lys Thr Arg Arg Asp Ala Ser Gly Asp Leu Leu 
            20                  25                  30          


Asn Thr Glu Ala His Ser Ala Pro Ala Gln Arg Trp Ser Met Gln Val 
        35                  40                  45              


Pro Ala Glu Val Asn Ala Glu Ala Gly Asp Ala Ala Val Leu Pro Cys 
    50                  55                  60                  


Thr Phe Thr His Pro His Arg His Tyr Asp Gly Pro Leu Thr Ala Ile 
65                  70                  75                  80  


Trp Arg Ser Gly Glu Pro Tyr Ala Gly Pro Gln Val Phe Arg Cys Thr 
                85                  90                  95      


Ala Ala Pro Gly Ser Glu Leu Cys Gln Thr Ala Leu Ser Leu His Gly 
            100                 105                 110         


Arg Phe Arg Leu Leu Gly Asn Pro Arg Arg Asn Asp Leu Ser Leu Arg 
        115                 120                 125             


Val Glu Arg Leu Ala Leu Ala Asp Ser Gly Arg Tyr Phe Cys Arg Val 
    130                 135                 140                 


Glu Phe Thr Gly Asp Ala His Asp Arg Tyr Glu Ser Arg His Gly Val 
145                 150                 155                 160 


Arg Leu Arg Val Thr Ala Ala Ala Pro Arg Ile Val Asn Ile Ser Val 
                165                 170                 175     


Leu Pro Gly Pro Ala His Ala Phe Arg Ala Leu Cys Thr Ala Glu Gly 
            180                 185                 190         


Glu Pro Pro Pro Ala Leu Ala Trp Ser Gly Pro Ala Pro Gly Asn Ser 
        195                 200                 205             


Ser Ala Ala Leu Gln Gly Gln Gly His Gly Tyr Gln Val Thr Ala Glu 
    210                 215                 220                 


Leu Pro Ala Leu Thr Arg Asp Gly Arg Tyr Thr Cys Thr Ala Ala Asn 
225                 230                 235                 240 


Ser Leu Gly Arg Ala Glu Ala Ser Val Tyr Leu Phe Arg Phe His Gly 
                245                 250                 255     


Ala Pro Gly Thr Ser Thr Leu Ala Leu Leu Leu Gly Ala Leu Gly Leu 
            260                 265                 270         


Lys Ala Leu Leu Leu Leu Gly Ile Leu Gly Ala Arg Ala Thr Arg Arg 
        275                 280                 285             


Arg Leu Asp His Leu Val Pro Gln Asp Thr Pro Pro Arg Ser Gln Ala 
    290                 295                 300                 


Gln Glu Ser Asn Tyr Glu Asn Leu Ser Gln Met Ser Pro Pro Gly His 
305                 310                 315                 320 


Gln Leu Pro Arg Val Cys Cys Glu Glu Leu Leu Ser His His His Leu 
                325                 330                 335     


Val Ile His His Glu Lys 
            340         


<210>  2
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Lys Ser Ile Trp Leu Leu Ala Cys Leu Ala Trp Val Leu Pro 
1               5                   10                  15      


Thr Gly Ser Phe Val Arg Thr Lys Ile Asp Thr Thr Glu Asn Leu Leu 
            20                  25                  30          


Asn Thr Glu Val His Ser Ser Pro Ala Gln Arg Trp Ser Met Gln Val 
        35                  40                  45              


Pro Pro Glu Val Ser Ala Glu Ala Gly Asp Ala Ala Val Leu Pro Cys 
    50                  55                  60                  


Thr Phe Thr His Pro His Arg His Tyr Asp Gly Pro Leu Thr Ala Ile 
65                  70                  75                  80  


Trp Arg Ala Gly Glu Pro Tyr Ala Gly Pro Gln Val Phe Arg Cys Ala 
                85                  90                  95      


Ala Ala Arg Gly Ser Glu Leu Cys Gln Thr Ala Leu Ser Leu His Gly 
            100                 105                 110         


Arg Phe Arg Leu Leu Gly Asn Pro Arg Arg Asn Asp Leu Ser Leu Arg 
        115                 120                 125             


Val Glu Arg Leu Ala Leu Ala Asp Asp Arg Arg Tyr Phe Cys Arg Val 
    130                 135                 140                 


Glu Phe Ala Gly Asp Val His Asp Arg Tyr Glu Ser Arg His Gly Val 
145                 150                 155                 160 


Arg Leu His Val Thr Ala Ala Pro Arg Ile Val Asn Ile Ser Val Leu 
                165                 170                 175     


Pro Ser Pro Ala His Ala Phe Arg Ala Leu Cys Thr Ala Glu Gly Glu 
            180                 185                 190         


Pro Pro Pro Ala Leu Ala Trp Ser Gly Pro Ala Leu Gly Asn Ser Leu 
        195                 200                 205             


Ala Ala Val Arg Ser Pro Arg Glu Gly His Gly His Leu Val Thr Ala 
    210                 215                 220                 


Glu Leu Pro Ala Leu Thr His Asp Gly Arg Tyr Thr Cys Thr Ala Ala 
225                 230                 235                 240 


Asn Ser Leu Gly Arg Ser Glu Ala Ser Val Tyr Leu Phe Arg Phe His 
                245                 250                 255     


Gly Ala Ser Gly Ala Ser Thr Val Ala Leu Leu Leu Gly Ala Leu Gly 
            260                 265                 270         


Phe Lys Ala Leu Leu Leu Leu Gly Val Leu Ala Ala Arg Ala Ala Arg 
        275                 280                 285             


Arg Arg Pro Glu His Leu Asp Thr Pro Asp Thr Pro Pro Arg Ser Gln 
    290                 295                 300                 


Ala Gln Glu Ser Asn Tyr Glu Asn Leu Ser Gln Met Asn Pro Arg Ser 
305                 310                 315                 320 


Pro Pro Ala Thr Met Cys Ser Pro 
                325             


<210>  3
<211>  4161
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' arm

<400>  3
gtctcagtca gggagtcatg cctgacactt tttagcaggc actcacgggc tgccagaggt       60

gatggtaaat actaccagaa gccaggagct aggagctctg ccaaagcaat gtctttgttc      120

tctggtcaat acctgctaag gacttctcgc cttctgcctt gagtcctcag ggtggcccct      180

gaggattctg cctaagacag agcatctctc tcttttgaac ccactcagca catgagcagg      240

aagcactgta tctgctaatg gaagctaaaa cagagcctct gaatgaaggg tctcagtgct      300

cccttaggct cctcgagcca tctctacctg cgccatccat ttagagcaca ctttagaata      360

tttcacagca ggatgaagat ctgtgaggaa ttcacagagg catgctgcct gatgttagag      420

cgactaagtt aagcctctat taccattttc tcctggcaaa gccaactgaa gcgatatgtc      480

accagcatgc ctccgctggc agcagagccc tcacctacct gggatcttgg cctcctctga      540

ctgcttttgg cattgctggg gtatttcaga gttcctcata gagtgggtaa ctaggggaat      600

ttcccccaaa cttcaggaca aaaaggtatt gttttttctt gcaagccctc tccccctttg      660

ggggcttttc cattgaaaac cttaaatgtt actctcacaa gctgcaggcc tgccgggcaa      720

ggagcaggtg aggaggcagt ggagaagcaa acctgtgtga gcttctgaat gtagcatgta      780

gtctacagag aaatagcaag gagatactgt atcggctact gcagcaagga gatactgtat      840

ccgctactgc agcaaggaga tactgtatcc actactgcag ccttcttttt tttttttttt      900

tttttttttt tttttgcagc cttcttaaaa acaaaacaaa aggccttgtc tctggagttt      960

aaactttcta tgcagcttct tttatttttg tttaatcaag tgaacagaag tttgtttttg     1020

gttttttttc cccccatggg gaaacaaaag aatattttgc acttgttctt aagcaactgg     1080

gcacagtggt ggggggcagg gagatggggg tgcagagccc gtcaggggca agctgtggtt     1140

ctgctactgt cagtcaccag ctgactttga gaagtcgctt gggccttcca agccctcagt     1200

ttccccctct ctaaaacggg ccattgacaa catctcctgg ggctgttatg tgttttaagt     1260

gaggtagaga atgactcaca atgccccccc ccccgccttc ttcagcagtc tggcctccac     1320

agcccctcat gcattctctg ccccctctga gagccaggct tcatgcttgc ctttgccagt     1380

tttttcgaga cagggtccca agtatcttta actccctatg tagacccagg ctttggtggc     1440

gcatgcgcgc ctttaatccc agcactcggg aggcagaggc aggtggattt ctgagttcaa     1500

ggccagtctg gtctacagag tgagttccag gacagccagg gctacacaga gaaaccctgt     1560

ctcaaaaaaa caaaaaaaca aaaaaaaaac aaaaaaacca aaaaccaaaa cccaaaaccc     1620

aaataaacaa acaaaaaacc aacctcccga tgtaggtaaa agtggcctga acgcctaata     1680

actctcctcc tgaacattga ggctttctgc acaggctgcc atgtctttca cagtcgtacc     1740

ttacagcttg gttccctgct ccccgtgcac agactgtcaa gcccaggtct ccgtggaatt     1800

cattctctgg actctgcata cacatacctc ctctctgttg ggctctacaa cccctgcctg     1860

ctatttccaa tccctgcaac tctttccacc agccctcatc cttctgaaag cctaaccccc     1920

tttcatccca gggtacaggg gagagatacc agagctaggt tgggtgctca gagactattc     1980

tggcaagggt gattcatcag ataacagagg ttgaatagga gagatctggc aagtgaaagt     2040

aggctggcga ccatgttcag actaaggcaa tattgtctgt atctttcatc agagcacctg     2100

gcagagcaca gcctaattac atgttcactg atctttctcc agctcgatga taggggaccc     2160

tgttcatctt tgtccccaca gctcatatcc cagcacctgg cgcagcgtgc ggaagtatcc     2220

aataaatgtt tgcagaattg atgaatgcac aatagcagac aatgtgtggg caatccgtgc     2280

ctgactccat gagcttgcaa gatgcagaat tcaagcctaa ggtcacagag ggtagggagt     2340

acaggaaaac tgaggtaggg ctgagggtgc acactcatag tcccagctgt taggaagctg     2400

agacaggaag attgcaagtt gaacttgtgg cttgtttgag ctacactgtc agacagacag     2460

acagacagac agacagacag acctaaggaa actttcttca gctagacgtc ctgacaggat     2520

cagcgcaatc atcacacagg tttctcacat ttgaaaggca gccaaacacg ttcttactaa     2580

ggataaacgt ccagcccccg acttgaattc aaacacgtag ttcaacttgt ccagagctaa     2640

aagagattaa gcctaagaac aggccgtgtg aaacaggaac tggggtttaa ctcgatggtc     2700

ttccagctct gtgcccacag caggatcaga ttggacattc agcattccag cccaaggtgc     2760

acaagaactc gctgcactct gcaggtgcag cacactaggg ccacccgggg cgggacttga     2820

atggaaggga aagggggatg ggggcaggtg agccatcctc tcccatcagg aaaaggtaat     2880

gagtccaaga gccaccataa tgagcttctg caagcggcag ctgggacctg tacatgttcc     2940

cgaaagcagt ggcagttccg gtgtggttct gtcgatccac aggtgtatgg gctctacagg     3000

agatggacta gcagcggtgg cttgagggca ttccaaccca agaagtcatt gaggctcact     3060

gaccacaaag agcactgggc ttagttagca tcaggaagaa ctggcttttc tctttccttg     3120

cctggatgtt ggccttcatg tacacatcta taacactctc tgccctgtct ttctcctctt     3180

gggtgctttc aggacagatg gcatggtggt gtggtataaa taaagggact gtgtataata     3240

caagcccaat tactccctgt aaaggtccct tttgtgcact gtgccccagg gcactgactg     3300

ggcaggctca accgcctgcc tcctcttggg gaggtaccac ccctggcata accttctgag     3360

actgaacacc tccataaaca cagcaacaca gagcccgatg gtttgccagc actgggtgaa     3420

ctggaagcag ggctcagctt ccacaaccct tggctccgca ttctgaagaa tgtggttcac     3480

caggtggtgg gcaaagtgag gctggagcag aggtgtcaac ctgtgggccg cacgcccttt     3540

tgggggggag ggtgttgact gaccctttcc taggagtcac ctaagactac ctgcatatca     3600

gatatttata ttatgattca taacagtaac aaaattacac caatgaagta gcaacaaaaa     3660

taattttatg gttggggtca ccacaacatg aggaactgta ttaaagggtc gcagcattag     3720

gaaggctgag aaccactggt cttgaggtac aatgcagtgt gtacccacca tgttaaagta     3780

cccaccacga gggtctttct ctgcctttta agcagccagc caggacgcag ttcacctggg     3840

ctggctctga ttctaaagga acttgtaact ctactggtgt gcttcaaagc accgcccccc     3900

cccccccccc cagggtctgg gtttctcaac tacaaataaa gactgttagc ccttcaggtg     3960

aatcacagct tcatgccttt agggcgttct aatacaggct ctgggtccag gcaggtctga     4020

gtgggacgca gactttgcct caacatcgca gttactccaa ttatttaact tttctgcgcc     4080

tcagtgtatt aacatgtaac aggctatcta catttgtctc taggatccct tgtgaaaact     4140

agaagagacg cttcggggga t                                               4161


<210>  4
<211>  4091
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' arm

<400>  4
tccaagctgc tgtccctgac cttgatgggt catctgctga gcacccagaa aagggaggga       60

ccttctcaga gcctctcagt cttggccaac caataaggtt agcctccaac tctccaggga      120

cacaacgcag aatttgtctc tgggggcccc agctgccatc cttgctgtga ccctgccatt      180

cttgctggtt cctcaaactt atcaaacatg ttgtgtttca gggtccccag aaaggcagtt      240

gtgttctctc ttaatatccc caccccgcct ccccgaccgg ggtcaagtta accctatcat      300

gtatcaggtt aagttgctcc agctagcaag ccatctgctg cacatttcct ggggactgcc      360

tctcactgtg gggcggggca atgtgtgaag ctgacaggtt ggctggagac cactgtgcaa      420

attcacacct cctctttctc catgtccctc atacagatca cctggtcccc caggacaccc      480

ctccacggta cgtactcact gcccttcccc catctctgcc taccacattg gcccaggcat      540

gccactttct cagaactggg agttcacaga gaaaaagcag gcatagggca aggctagggt      600

agtaggctgg actagggcct ggatcatacc caaaatgccc tgcccctcca tccagcacac      660

cccagagtgg gccaggctga cctgttactg catccagtac acaaggagct tgctgtctat      720

gaccccaaaa gcgaatacca ctaagctgtg tcctcctgtt gcctcccagc tttctagaaa      780

ttagccccag aaggatgcca ctgtaggaag actcatcccc caggcttaat gctgactgct      840

tccaaacaaa atcaccaaga gcctggctta gatgaaagat ctagaaagac attaagccag      900

agtccactct ttcctcttca gtgtctaccc cagtaaggac ccttgttgag ggagtaagaa      960

cccagctctg gagtgctgtg cctggtgctg gctgggagca cactctttcc tgctgctcaa     1020

gtcttgacag cccgccatat gtgcatctcc tttactgacg tgcaacaaga tcagagtcac     1080

aacactgcct gatgtacact cacctaacaa atatttaccg aatacctacg atctagcagg     1140

caataacatg gatgatagag actggaaatc caagcttact ctccaatgtg cacagttttg     1200

cacaaacata acaagaccat ctgagatctg taaagctagg gataaagcag tgcccagtgg     1260

gtagccaggc ggccatgact gctttagagc tggatacttt ctttgaagac atggccctaa     1320

agacaccaag ctggaggctg gaacctaggg tgaccaaggt gatagggata tcccaagagt     1380

gaaaactgta aaaggatctt ctgttctcct gaagtaactg tcatctctaa ggctcactgc     1440

ctccatctgc taacctaagc ctagttctgg aagcttctag ccttcgtaca atctaatcta     1500

ggcctagaat gttttcaggc tctgagactc actgctgaat aagttcaccc cttctagctc     1560

tttctgagct ctggctggct aattcaactc agctgttctg gctcaaactc ctctcaaagc     1620

tgactgatac agtctggctt ctctcttgga ctctgatatt tttgctgtgc ttggcgtcta     1680

agtctggcaa tctgttctaa ccttctggct ccttctcctt ctctggcttg tcttgtcttc     1740

accagtgtct agcttgcttg ttctctcttc aacctgtgtc tgtacaactc tcccagtaaa     1800

actgcttgct tgcttcctct gtctctgtct ctctcttctt cttcttttct cctcctcctc     1860

ctcctcctcc tcctcctcct tcttcttctt cttcttcttc ttctctctct ctctctctct     1920

ctctctctct ctctctctct ctctctctct gcactgctcc cttaagtagc ttccctttcc     1980

tctctctcct catgagagtt gggcgtatcc tattctgtca aatctttctc cgactcatca     2040

ctttgtctgc cactcaatta gacttaactt tcaagcatgc atgcttcctt ctacaaacta     2100

acttcacctt cattgtttgg gattaaaagt gtgtactaag ggttgagcta taactagaaa     2160

caggcttttt tttttttcag taaataacac aatctctcag ggttcactgt gtgatcaaat     2220

atcctgcaac agaaaacctt aagtagaaag gtcaggtggg atttggaatg gacacagaca     2280

tggggggagc atggaaatgt gggttaagat ggcaaggttg gggcaattct gggtgaggtg     2340

gaaatcagaa tggtttggag tcatacatga gaggttgaat ctgaacagaa gggcccaaga     2400

aatacacccc aaaagcggct gctgtttttt ctgctctggc agcaaccagg ggaagggact     2460

ctctgaggtg aagggaggga agcaggatat ccagagttag agttgagtcc tagtcacaga     2520

gaccaggagg gaatggagta ggggaggggt gtgcgctttg tctcccacgg tgggtgggag     2580

gttggaggta gggatgtctg ggaagcagtc agatctgagg agattgggga catggagctg     2640

gggtctgaaa cctctgacaa agtcactttg taggagatgg taactgatca aggacgctat     2700

caccagcagc atccatcccc ctgtcttatg ttaatcaatt ccccagcctt gctgcttctg     2760

gctccactgc ctcccatgta gtatctttct tgacctgttg ttggggcaca gcttgggaag     2820

tcaaggacct cgccacatat tgggtggtaa gttgattttc tcctgtctac aggtctcagg     2880

ctcaggagtc caattatgaa aatttgagcc agatgagtcc tccaggccac cagctgccac     2940

gtgtttgctg tgaggaactc ctcagccatc accatctagt cattcaccat gagaaataaa     3000

ggacagtacc aggctagacc tggacagctc ataattccca ggttccttgg ccaggcaaca     3060

tccaagggga ccaggaccct gctcacagag gctccgagcc tcacggtatt ataacaacag     3120

tggagccagc aatctgggtg tatatgtatg ccgacatgag cctcagcatg aaacttctgg     3180

aaaaactccc cttgttttat tctttcttag aactacgtag taaagcagac aggaaactag     3240

ccataatgtc tggaggtcca ggctccagtc tgctctgtca tggacttcca gtgcggacca     3300

ggacacttca cctatctggg gctcagctga agaaatagaa gatctgaaag acctgcataa     3360

actccaacgc tagctcaaag gtgggcctct ggattgctga attcttaggt aggtgtggca     3420

ctgctcagcc ctgtggagaa caaagcctga gactggagct gtgcaaactg atcagaggta     3480

cagcaaaccc tgggaatgtt atagcaagaa gtgtggagcc cctgcctacc tgtgatcata     3540

tcagctgacc cacacttcct taatctggga cccaccaaga gaaggagact gaagacccat     3600

agtctcaaag catctgaaag ctgtatgtca aaacctggga gacctgaagg ggctctgggt     3660

cccagtagtt aaggcagctg tggctctgac ccctcctggg gagtgcactc cctcctagga     3720

tgtgaaagtc caggagatct ggcagtgtct tcccacttgc ccaaacccag ccaggctaac     3780

ttcaagagtg gtgctttcct tatttacact tcgggtgcat ttgttggtcc tattaaagga     3840

gagaggtgta cttgggacca agtgagccac aagacaggag gctaaggaga ccatgttttt     3900

ctggggacgg catctctatg tacagggcaa tcggtttcag gcttcccact gcgccagagc     3960

ttcaggcgag gcggagctca gccaagggca atggcagatc atagttattc ccagatccat     4020

cgagagctgt taagaaagca catgggagat ctttccatct tctgagactc gaagttctta     4080

tcatacagat c                                                          4091


<210>  5
<211>  1893
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide 45837067-45838959 of NCBI accession number 
       NC_000018.10

<400>  5
ttgctcaaca cagaggtgca cagtaagtgc ttttattatt atcaccatct cggggatctt       60

gggagtctgt tttaaccacg agatcccagg gtttttccac agggcaggtt ttgatgggga      120

aaaactaagg gtaagaatat ggggtcaagg ggcctgcagg tgaattagga aacgaagagg      180

ggaatagtcc cagggaagag ccgcgggaac gcaggcactc ccaagtcgag ggagtgcagg      240

ccctgggggt gcaggcacca ggaattgccc ctcaagtcac aaggtggggt tccggctccc      300

ctggaagtgg gggacgatcc ctgagtcctg gggtttccag gctaggggtt gggggagcgt      360

ttcctgggtc gtggggtttc caggccccgg gtgcgggcgc ctcgacccca gggccccgag      420

cctgacgcag cccgccccgc cctcaggctc gccagcgcag cgctggtcca tgcaggtgcc      480

acccgaggtg agcgcggagg caggcgacgc ggcagtgctg ccctgcacct tcacgcaccc      540

gcaccgccac tacgacgggc cgctgacggc catctggcgc gcgggcgagc cctatgcggg      600

cccgcaggtg ttccgctgcg ctgcggcgcg gggcagcgag ctctgccaga cggcgctgag      660

cctgcacggc cgcttccggc tgctgggcaa cccgcgccgc aacgacctct cgctgcgcgt      720

cgagcgcctc gccctggctg acgaccgccg ctacttctgc cgcgtcgagt tcgccggcga      780

cgtccatgac cgctacgaga gccgccacgg cgtccggctg cacgtgacag gcgaggcggc      840

gtgggagcgg gtccccggcc tcccttcccg ccctcccgcc tgccccgccc caagggctac      900

gtgggtgcca ggcgctgtgc tgagccagga agggcaacga gacccagccc tctcctctac      960

cccagggatc tcacacctgg gggtagttta ggaccacctg ggagcttgac acaaatgcag     1020

aatccaggtc ccaggaaggg ctgaggtggg cccgggaata ggcattgccg tgactctcgt     1080

agagtgactg tccccagtgg ctctcagacg aagaggcgag aaagacaagt gaatggcaat     1140

cctaaatatg ccaagaggtg caatgtggtg tgtgctacca gcccggaaag acactcgcag     1200

cccctctacc caggggtgca cagacagccc accaagtagt gcctagcact ttgccagacc     1260

ctgatataca aagatgcctg aaccagggtc ccgtccctag agcagtggct ctccactcta     1320

gcccccaccc tgctctgcga caataatggc cacttagcat ttgctaggga gccgggacct     1380

agtccaagca cccacaagca tgaatttgcc aaatcttttc agcaacctct taaggcaact     1440

gctatcatga tcctcacttt acacatggag aagcagaagc agagatgata gaatctttcg     1500

cccaaggcca catctgtatt gggacggggg cagcctggca cccaagtgcc cattcctccc     1560

ttctgaccag cccccacccc tccggctctg gcgtccaaag ggctaagggg aggggtgccc     1620

ttgtgacagt cacccgcctt ctcccctgca gccgcgccgc ggatcgtcaa catctcggtg     1680

ctgcccagtc cggctcacgc cttccgcgcg ctctgcactg ccgaagggga gccgccgccc     1740

gccctcgcct ggtccggccc ggccctgggc aacagcttgg cagccgtgcg gagcccgcgt     1800

gagggtcacg gccacctagt gaccgccgaa ctgcccgcac tgacccatga cggccgctac     1860

acgtgtacgg ccgccaacag cctgggccgc tcc                                  1893


<210>  6
<211>  80
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection between the human SIGLEC15 sequence in fragment A and 
       the downstream mouse sequence

<400>  6
ccgctacacg tgtacggccg ccaacagcct gggccgctcc gaggccagcg tctacctgtt       60

ccgcttccac ggcgcccccg                                                   80


<210>  7
<211>  80
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection between the 5' end of the Neo cassette and the 
       upstream mouse sequence

<400>  7
ctggcctggg aacccaggtt acttttagag tctcagtact aagcttgata tcgaattccg       60

aagttcctat tctctagaaa                                                   80


<210>  8
<211>  80
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection bteween the 3' end of the Neo cassette with the 
       downstream mouse sequence

<400>  8
aggtacataa tggtggatcc actagttcta gagcggccgc tccaagctgc tgtccctgac       60

cttgatgggt catctgctga                                                   80


<210>  9
<211>  2326
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mRNA sequence of the SIGLEC15 humanized mouse

<400>  9
acaccgctgg ctacttggct gcggctgcct agctcctcca gtttgcttag agcccagcgg       60

ccctgcagac ttggcacaga gcacacccac ctgcctttgt cacagcacac taagaaggtt      120

ctctgtggtg accaggctgg gtagagggct gctgggtctg caggcgtcag agcatggagg      180

ggtccctcca actcctggcc tgcttggcct gtgtgctcca gatgggatcc cttgtgaaaa      240

ctagaagaga cgcttcgggg gatttgctca acacagaggt gcacagctcg ccagcgcagc      300

gctggtccat gcaggtgcca cccgaggtga gcgcggaggc aggcgacgcg gcagtgctgc      360

cctgcacctt cacgcacccg caccgccact acgacgggcc gctgacggcc atctggcgcg      420

cgggcgagcc ctatgcgggc ccgcaggtgt tccgctgcgc tgcggcgcgg ggcagcgagc      480

tctgccagac ggcgctgagc ctgcacggcc gcttccggct gctgggcaac ccgcgccgca      540

acgacctctc gctgcgcgtc gagcgcctcg ccctggctga cgaccgccgc tacttctgcc      600

gcgtcgagtt cgccggcgac gtccatgacc gctacgagag ccgccacggc gtccggctgc      660

acgtgacagc cgcgccgcgg atcgtcaaca tctcggtgct gcccagtccg gctcacgcct      720

tccgcgcgct ctgcactgcc gaaggggagc cgccgcccgc cctcgcctgg tccggcccgg      780

ccctgggcaa cagcttggca gccgtgcgga gcccgcgtga gggtcacggc cacctagtga      840

ccgccgaact gcccgcactg acccatgacg gccgctacac gtgtacggcc gccaacagcc      900

tgggccgctc cgaggccagc gtctacctgt tccgcttcca cggcgccccc ggaacctcga      960

ccctagcgct cctgctgggc gcgctgggcc tcaaggcctt gctgctgctt ggcattctgg     1020

gagcgcgtgc cacccgacgc cgactagatc acctggtccc ccaggacacc cctccacggt     1080

ctcaggctca ggagtccaat tatgaaaatt tgagccagat gagtcctcca ggccaccagc     1140

tgccacgtgt ttgctgtgag gaactcctca gccatcacca tctagtcatt caccatgaga     1200

aataaaggac agtaccaggc tagacctgga cagctcataa ttcccaggtt ccttggccag     1260

gcaacatcca aggggaccag gaccctgctc acagaggctc cgagcctcac ggtattataa     1320

caacagtgga gccagcaatc tgggtgtata tgtatgccga catgagcctc agcatgaaac     1380

ttctggaaaa actccccttg ttttattctt tcttagaact acgtagtaaa gcagacagga     1440

aactagccat aatgtctgga ggtccaggct ccagtctgct ctgtcatgga cttccagtgc     1500

ggaccaggac acttcaccta tctggggctc agctgaagaa atagaagatc tgaaagacct     1560

gcataaactc caacgctagc tcaaaggtgg gcctctggat tgctgaattc ttaggtaggt     1620

gtggcactgc tcagccctgt ggagaacaaa gcctgagact ggagctgtgc aaactgatca     1680

gaggtacagc aaaccctggg aatgttatag caagaagtgt ggagcccctg cctacctgtg     1740

atcatatcag ctgacccaca cttccttaat ctgggaccca ccaagagaag gagactgaag     1800

acccatagtc tcaaagcatc tgaaagctgt atgtcaaaac ctgggagacc tgaaggggct     1860

ctgggtccca gtagttaagg cagctgtggc tctgacccct cctggggagt gcactccctc     1920

ctaggatgtg aaagtccagg agatctggca gtgtcttccc acttgcccaa acccagccag     1980

gctaacttca agagtggtgc tttccttatt tacacttcgg gtgcatttgt tggtcctatt     2040

aaaggagaga ggtgtacttg ggaccaagtg agccacaaga caggaggcta aggagaccat     2100

gtttttctgg ggacggcatc tctatgtaca gggcaatcgg tttcaggctt cccactgcgc     2160

cagagcttca ggcgaggcgg agctcagcca agggcaatgg cagatcatag ttattcccag     2220

atccatcgag agctgttaag aaagcacatg ggagatcttt ccatcttctg agactcgaag     2280

ttcttatcat acagatcttt cacttgctta gttagagtca caccaa                    2326


<210>  10
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  expressed protein sequence of the SIGLEC15 humanized mouse

<400>  10

Met Glu Gly Ser Leu Gln Leu Leu Ala Cys Leu Ala Cys Val Leu Gln 
1               5                   10                  15      


Met Gly Ser Leu Val Lys Thr Arg Arg Asp Ala Ser Gly Asp Leu Leu 
            20                  25                  30          


Asn Thr Glu Val His Ser Ser Pro Ala Gln Arg Trp Ser Met Gln Val 
        35                  40                  45              


Pro Pro Glu Val Ser Ala Glu Ala Gly Asp Ala Ala Val Leu Pro Cys 
    50                  55                  60                  


Thr Phe Thr His Pro His Arg His Tyr Asp Gly Pro Leu Thr Ala Ile 
65                  70                  75                  80  


Trp Arg Ala Gly Glu Pro Tyr Ala Gly Pro Gln Val Phe Arg Cys Ala 
                85                  90                  95      


Ala Ala Arg Gly Ser Glu Leu Cys Gln Thr Ala Leu Ser Leu His Gly 
            100                 105                 110         


Arg Phe Arg Leu Leu Gly Asn Pro Arg Arg Asn Asp Leu Ser Leu Arg 
        115                 120                 125             


Val Glu Arg Leu Ala Leu Ala Asp Asp Arg Arg Tyr Phe Cys Arg Val 
    130                 135                 140                 


Glu Phe Ala Gly Asp Val His Asp Arg Tyr Glu Ser Arg His Gly Val 
145                 150                 155                 160 


Arg Leu His Val Thr Ala Ala Pro Arg Ile Val Asn Ile Ser Val Leu 
                165                 170                 175     


Pro Ser Pro Ala His Ala Phe Arg Ala Leu Cys Thr Ala Glu Gly Glu 
            180                 185                 190         


Pro Pro Pro Ala Leu Ala Trp Ser Gly Pro Ala Leu Gly Asn Ser Leu 
        195                 200                 205             


Ala Ala Val Arg Ser Pro Arg Glu Gly His Gly His Leu Val Thr Ala 
    210                 215                 220                 


Glu Leu Pro Ala Leu Thr His Asp Gly Arg Tyr Thr Cys Thr Ala Ala 
225                 230                 235                 240 


Asn Ser Leu Gly Arg Ser Glu Ala Ser Val Tyr Leu Phe Arg Phe His 
                245                 250                 255     


Gly Ala Pro Gly Thr Ser Thr Leu Ala Leu Leu Leu Gly Ala Leu Gly 
            260                 265                 270         


Leu Lys Ala Leu Leu Leu Leu Gly Ile Leu Gly Ala Arg Ala Thr Arg 
        275                 280                 285             


Arg Arg Leu Asp His Leu Val Pro Gln Asp Thr Pro Pro Arg Ser Gln 
    290                 295                 300                 


Ala Gln Glu Ser Asn Tyr Glu Asn Leu Ser Gln Met Ser Pro Pro Gly 
305                 310                 315                 320 


His Gln Leu Pro Arg Val Cys Cys Glu Glu Leu Leu Ser His His His 
                325                 330                 335     


Leu Val Ile His His Glu Lys 
            340             


<210>  11
<211>  1349
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' arm

<400>  11
ggacttgaat ggaagggaaa gggggatggg ggcaggtgag ccatcctctc ccatcaggaa       60

aaggtaatga gtccaagagc caccataatg agcttctgca agcggcagct gggacctgta      120

catgttcccg aaagcagtgg cagttccggt gtggttctgt cgatccacag gtgtatgggc      180

tctacaggag atggactagc agcggtggct tgagggcatt ccaacccaag aagtcattga      240

ggctcactga ccacaaagag cactgggctt agttagcatc aggaagaact ggcttttctc      300

tttccttgcc tggatgttgg ccttcatgta cacatctata acactctctg ccctgtcttt      360

ctcctcttgg gtgctttcag gacagatggc atggtggtgt ggtataaata aagggactgt      420

gtataataca agcccaatta ctccctgtaa aggtcccttt tgtgcactgt gccccagggc      480

actgactggg caggctcaac cgcctgcctc ctcttgggga ggtaccaccc ctggcataac      540

cttctgagac tgaacacctc cataaacaca gcaacacaga gcccgatggt ttgccagcac      600

tgggtgaact ggaagcaggg ctcagcttcc acaacccttg gctccgcatt ctgaagaatg      660

tggttcacca ggtggtgggc aaagtgaggc tggagcagag gtgtcaacct gtgggccgca      720

cgcccttttg ggggggaggg tgttgactga ccctttccta ggagtcacct aagactacct      780

gcatatcaga tatttatatt atgattcata acagtaacaa aattacacca atgaagtagc      840

aacaaaaata attttatggt tggggtcacc acaacatgag gaactgtatt aaagggtcgc      900

agcattagga aggctgagaa ccactggtct tgaggtacaa tgcagtgtgt acccaccatg      960

ttaaagtacc caccacgagg gtctttctct gccttttaag cagccagcca ggacgcagtt     1020

cacctgggct ggctctgatt ctaaaggaac ttgtaactct actggtgtgc ttcaaagcac     1080

cgcccccccc ccccccccca gggtctgggt ttctcaacta caaataaaga ctgttagccc     1140

ttcaggtgaa tcacagcttc atgcctttag ggcgttctaa tacaggctct gggtccaggc     1200

aggtctgagt gggacgcaga ctttgcctca acatcgcagt tactccaatt atttaacttt     1260

tctgcgcctc agtgtattaa catgtaacag gctatctaca tttgtctcta ggatcccttg     1320

tgaaaactag aagagacgct tcgggggat                                       1349


<210>  12
<211>  1345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' arm

<400>  12
gaggccagcg tctacctgtt ccgcttccac ggcgcccccg gaacctcgac cctagcgctc       60

ctgctgggcg cgctgggcct caaggccttg ctgctgcttg gcattctggg agcgcgtgcc      120

acccgacgcc gactaggtgg gtgcatccca gatctgggtg ggtgagaggg ggagagaagg      180

ctccctgccc tttctgccgg tccacctgat gtggcacatc agaaatcctt tctgcacctg      240

catccttctc tctgcctgga gcccatgaga tggagctctt cgcagttagg aaatggtggc      300

tctgcaaagg attttgagtc acacagagac acaggcctgt aggctctcca acacttcttt      360

tactaactac cacgccacaa atcagtgtcc tgtaaaggtc gggtctccgg cttctccctt      420

acttttaact agcgtcttga ggtcctgagg ttatggacca ggatgctggg aacgcaaaga      480

tgctcagatg tgattccctg ctagccggta agaggctggg tctgcagaac tccttttcat      540

ggaggtactg cagaaggcag aaattgcaga agacaggggg aggggggata tcttgcaatt      600

ctgaggtctt agtaagttag gagggctcag ccaaaaaaaa aaaaaataaa taaaataaag      660

ccttcaggac acaggagctt ggaaatcata aatggctcac ctggcctggg aacccaggtt      720

acttttagag tctctccaag ctgctgtccc tgaccttgat gggtcatctg ctgagcaccc      780

agaaaaggga gggaccttct cagagcctct cagtcttggc caaccaataa ggttagcctc      840

caactctcca gggacacaac gcagaatttg tctctggggg ccccagctgc catccttgct      900

gtgaccctgc cattcttgct ggttcctcaa acttatcaaa catgttgtgt ttcagggtcc      960

ccagaaaggc agttgtgttc tctcttaata tccccacccc gcctccccga ccggggtcaa     1020

gttaacccta tcatgtatca ggttaagttg ctccagctag caagccatct gctgcacatt     1080

tcctggggac tgcctctcac tgtggggcgg ggcaatgtgt gaagctgaca ggttggctgg     1140

agaccactgt gcaaattcac acctcctctt tctccatgtc cctcatacag atcacctggt     1200

cccccaggac acccctccac ggtacgtact cactgccctt cccccatctc tgcctaccac     1260

attggcccag gcatgccact ttctcagaac tgggagttca cagagaaaaa gcaggcatag     1320

ggcaaggcta gggtagtagg ctgga                                           1345


<210>  13
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  13
cccctcgact tccggaggca ggg                                               23


<210>  14
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  14
ggtagtgtgg gtcacacgcc agg                                               23


<210>  15
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  15
tccctgcctc cggaagtcga ggg                                               23


<210>  16
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  16
tgtgctcccc cataactaaa agg                                               23


<210>  17
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  17
ccactcccct cgacttccgg agg                                               23


<210>  18
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  18
ttggacagtt tgtttcatcc tgg                                               23


<210>  19
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  19
aaagagttgc tgagatgcta tgg                                               23


<210>  20
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  20
cccgtattac aagatcccta agg                                               23


<210>  21
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  21
ttgcccgcgc tgacccgcga cgg                                               23


<210>  22
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  22
gtgcacggcg gccaatagcc tgg                                               23


<210>  23
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  23
tggccgccgt gcacgtgtag cgg                                               23


<210>  24
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  24
tgcacggcgg ccaatagcct ggg                                               23


<210>  25
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  25
tcacctggta gccgtgaccc tgg                                               23


<210>  26
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  26
gcctggtcgg gtcccgcccc agg                                               23


<210>  27
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  27
gcctggggcg ggacccgacc agg                                               23


<210>  28
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  28
agggcagcgg agctgttgcc tgg                                               23


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA2 upstream sequence

<400>  29
ggtagtgtgg gtcacacgcc                                                   20


<210>  30
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward strand of sgRNA2

<400>  30
taggggtagt gtgggtcaca cgcc                                              24


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA2 downstream sequence

<400>  31
ggcgtgtgac ccacactacc                                                   20


<210>  32
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse strand of sgRNA2

<400>  32
aaacggcgtg tgacccacac tacc                                              24


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA12 upstream sequence

<400>  33
tgcacggcgg ccaatagcct                                                   20


<210>  34
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward strand of sgRNA12

<400>  34
taggtgcacg gcggccaata gcct                                              24


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA12 downstream sequence

<400>  35
aggctattgg ccgccgtgca                                                   20


<210>  36
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse strand of sgRNA12

<400>  36
aaacaggcta ttggccgccg tgca                                              24


<210>  37
<211>  132
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA fragment containing the T7 promoter and sgRNA scaffold

<400>  37
gaattctaat acgactcact atagggggtc ttcgagaaga cctgttttag agctagaaat       60

agcaagttaa aataaggcta gtccgttatc aacttgaaaa agtggcaccg agtcggtgct      120

tttaaaggat cc                                                          132


<210>  38
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  38
aagcctaaga acaggccgtg tgaaa                                             25


<210>  39
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  39
tagcacacac cacattgcac ctctt                                             25


<210>  40
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  40
cctctacccc agggatctca cacc                                              24


<210>  41
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  41
acatcaggca gtgttgtgac tctga                                             25


<210>  42
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  42
cagcttcatg cctttagggc gttct                                             25


<210>  43
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  43
gggccagaga cacatcagac ttagc                                             25


<210>  44
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  44
tgggactatt cccctcttcg tttcc                                             25


<210>  45
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  45
tggcctgaac gcctaataac tctcc                                             25


<210>  46
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  46
catggtcgcc agcctacttt cactt                                             25


<210>  47
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  47
ccaccctgct ctgcgacaat aatgg                                             25


<210>  48
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  48
gcaccgagat gttgacgatc cgc                                               23


<210>  49
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  49
gagagtcgcc atggggtccg                                                   20


<210>  50
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  50
gctcggagcc tctgtgagca g                                                 21


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  51
cgtccatgac cgctacgaga                                                   20


<210>  52
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  52
tgactagatg gtgatggctg agg                                               23


<210>  53
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  53
tcaccatctt ccaggagcga ga                                                22


<210>  54
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  54
gaaggccatg ccagtgagct t                                                 21


<210>  55
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  55
tttgcctcaa catcgcagtt actcca                                            26


<210>  56
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  56
ctcaaaatcc tttgcagagc cacca                                             25


<210>  57
<211>  341
<212>  PRT
<213>  Rattus norvegicus

<400>  57

Met Glu Gly Phe Leu Gln Leu Leu Ala Cys Leu Ala Cys Val Leu Gln 
1               5                   10                  15      


Met Gly Ser Pro Val Lys Thr Arg Arg Asp Ala Leu Gly Asn Ala Leu 
            20                  25                  30          


Asn Thr Glu Glu Leu Ser Ala Pro Ser Gln Arg Trp Ser Met Gln Val 
        35                  40                  45              


Pro Ala Glu Val Ser Ala Glu Val Gly Asp Met Ala Val Leu Pro Cys 
    50                  55                  60                  


Thr Phe Thr His Pro His Arg His Tyr Asp Gly Pro Leu Thr Ala Ile 
65                  70                  75                  80  


Trp Arg Ala Gly Glu Pro Tyr Ala Gly Pro Gln Val Phe Arg Cys Thr 
                85                  90                  95      


Ala Ala Pro Gly Ser Glu Leu Cys Gln Thr Ala Leu Ser Leu His Gly 
            100                 105                 110         


Arg Phe Arg Leu Leu Gly Asn Pro Arg Arg Asn Asp Leu Ser Leu Arg 
        115                 120                 125             


Val Glu Arg Leu Ala Leu Ala Asp Ser Arg Arg Tyr Phe Cys Arg Val 
    130                 135                 140                 


Glu Phe Thr Gly Asp Ala His Asp Arg Tyr Glu Ser Arg His Gly Val 
145                 150                 155                 160 


Arg Leu His Val Thr Ala Ala Pro Arg Ile Val Asn Ile Ser Val Leu 
                165                 170                 175     


Pro Gly Thr Ser His Ala Phe Arg Ala Leu Cys Thr Ala Glu Gly Glu 
            180                 185                 190         


Pro Pro Pro Thr Leu Ala Trp Ser Gly Pro Ala Leu Gly Asn Ser Ser 
        195                 200                 205             


Ala Ala Met Gln Gly Gln Gly Arg Gly Tyr Gln Val Thr Ala Glu Leu 
    210                 215                 220                 


Pro Ala Leu Thr Arg Asp Gly Arg Tyr Thr Cys Thr Ala Ala Asn Ser 
225                 230                 235                 240 


Leu Gly Arg Ala Glu Ala Ser Val Tyr Leu Phe Arg Phe His Gly Ala 
                245                 250                 255     


Pro Ala Ala Ser Thr Leu Ala Leu Leu Leu Gly Ala Leu Gly Leu Lys 
            260                 265                 270         


Ala Leu Leu Leu Leu Gly Leu Leu Gly Ala Arg Ala Thr Arg Arg Arg 
        275                 280                 285             


Gly Asp His Leu Ala Ala Gln Asp Thr Pro Pro Arg Ser Gln Ala Gln 
    290                 295                 300                 


Glu Ser Asn Tyr Glu Asn Leu Ser Gln Met Asn Pro Pro Gly Tyr Gln 
305                 310                 315                 320 


Leu Pro Arg Val Cys Cys Glu Glu Leu Leu Asn His His His Pro Val 
                325                 330                 335     


Ile His His Glu Lys 
            340     


