                         SEQUENCE LISTING

<110>  ɽҽҩ޹˾
 
<120>  пPD-1-VEGFA˫Կҩϼ;

<130>  IEC210077PCT

<150>  CN202110270652.7
<151>  2021-03-12

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bevacizumab-Hv

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Pro His Tyr Tyr Gly Ser Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  2
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid encoding Bevacizumab-Hv

<400>  2
gaggtgcagc tggtcgagtc cggggggggg ctggtgcagc caggcgggtc tctgaggctg       60

agttgcgccg cttcagggta caccttcaca aactatggaa tgaattgggt gcgccaggca      120

ccaggaaagg gactggagtg ggtcggctgg atcaacactt acaccgggga acctacctat      180

gcagccgact ttaagcggcg gttcaccttc agcctggata caagcaaatc cactgcctac      240

ctgcagatga acagcctgcg agctgaggac accgcagtct actattgtgc taaatatccc      300

cactactatg ggagcagcca ttggtatttt gacgtgtggg ggcaggggac tctggtgaca      360

gtgagcagc                                                              369


<210>  3
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bevacizumab-Lv

<400>  3

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  4
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid encoding Bevacizumab-Lv

<400>  4
gatattcaga tgactcagag cccctcctcc ctgtccgcct ctgtgggcga cagggtcacc       60

atcacatgca gtgcttcaca ggatatttcc aactacctga attggtatca gcagaagcca      120

ggaaaagcac ccaaggtgct gatctacttc actagctccc tgcactcagg agtgccaagc      180

cggttcagcg gatccggatc tggaaccgac tttactctga ccatttctag tctgcagcct      240

gaggatttcg ctacatacta ttgccagcag tattctaccg tgccatggac atttggccag      300

gggactaaag tcgagatcaa g                                                321


<210>  5
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of 14C12

<400>  5

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Arg Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Arg Tyr Gly Glu Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  6
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid encoding VH of 14C12

<400>  6
gaggtcaaac tggtggagag cggcggcggg ctggtgaagc ccggcgggtc actgaaactg       60

agctgcgccg cttccggctt cgcctttagc tcctacgaca tgtcatgggt gaggcagacc      120

cctgagaagc gcctggaatg ggtcgctact atcagcggag gcgggcgata cacctactat      180

cctgactctg tcaaagggag attcacaatt agtcgggata acgccagaaa tactctgtat      240

ctgcagatgt ctagtctgcg gtccgaggat acagctctgt actattgtgc aaaccggtac      300

ggcgaagcat ggtttgccta ttggggacag ggcaccctgg tgacagtctc tgcc            354


<210>  7
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of 14C12

<400>  7

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Phe Thr Cys Lys Ala Ser Gln Asp Ile Asn Thr Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  8
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid encoding VL of 14C12

<400>  8
gacattaaga tgacacagtc cccttcctca atgtacgcta gcctgggcga gcgagtgacc       60

ttcacatgca aagcatccca ggacatcaac acatacctgt cttggtttca gcagaagcca      120

ggcaaaagcc ccaagaccct gatctaccgg gccaatagac tggtggacgg ggtccccagc      180

agattctccg gatctggcag tgggcaggat tactccctga ccatcagctc cctggagtat      240

gaagacatgg gcatctacta ttgcctgcag tatgatgagt tccctctgac ctttggagca      300

ggcacaaaac tggaactgaa g                                                321


<210>  9
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of 14C12H1L1

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Arg Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Arg Tyr Gly Glu Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  10
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid encoding VH of 14C12H1L1

<400>  10
gaagtgcagc tggtcgagtc tgggggaggg ctggtgcagc ccggcgggtc actgcgactg       60

agctgcgcag cttccggatt cgcctttagc tcctacgaca tgtcctgggt gcgacaggca      120

ccaggaaagg gactggattg ggtcgctact atctcaggag gcgggagata cacctactat      180

cctgacagcg tcaagggccg gttcacaatc tctagagata acagtaagaa caatctgtat      240

ctgcagatga acagcctgag ggctgaggac accgcactgt actattgtgc caaccgctac      300

ggggaagcat ggtttgccta ttgggggcag ggaaccctgg tgacagtctc tagt            354


<210>  11
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of 14C12H1L1

<400>  11

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Phe Thr Cys Arg Ala Ser Gln Asp Ile Asn Thr Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Met Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  12
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid encoding VL of 14C12H1L1

<400>  12
gacattcaga tgactcagag cccctcctcc atgtccgcct ctgtgggcga cagggtcacc       60

ttcacatgcc gcgctagtca ggatatcaac acctacctga gctggtttca gcagaagcca      120

gggaaaagcc ccaagacact gatctaccgg gctaatagac tggtgtctgg agtcccaagt      180

cggttcagtg gctcagggag cggacaggac tacactctga ccatcagctc cctgcagcct      240

gaggacatgg caacctacta ttgcctgcag tatgatgagt tcccactgac ctttggcgcc      300

gggacaaaac tggagctgaa g                                                321


<210>  13
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain of 14C12H1L1

<400>  13

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Arg Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Arg Tyr Gly Glu Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  14
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid encoding heavy chain of 14C12H1L1

<400>  14
gaagtgcagc tggtcgagtc tgggggaggg ctggtgcagc ccggcgggtc actgcgactg       60

agctgcgcag cttccggatt cgcctttagc tcctacgaca tgtcctgggt gcgacaggca      120

ccaggaaagg gactggattg ggtcgctact atctcaggag gcgggagata cacctactat      180

cctgacagcg tcaagggccg gttcacaatc tctagagata acagtaagaa caatctgtat      240

ctgcagatga acagcctgag ggctgaggac accgcactgt actattgtgc caaccgctac      300

ggggaagcat ggtttgccta ttgggggcag ggaaccctgg tgacagtctc tagtgccagc      360

accaaaggac ctagcgtgtt tcctctcgcc ccctcctcca aaagcaccag cggaggaacc      420

gctgctctcg gatgtctggt gaaggactac ttccctgaac ccgtcaccgt gagctggaat      480

agcggcgctc tgacaagcgg agtccataca ttccctgctg tgctgcaaag cagcggactc      540

tattccctgt ccagcgtcgt cacagtgccc agcagcagcc tgggcaccca gacctacatc      600

tgtaacgtca accacaagcc ctccaacacc aaggtggaca agaaagtgga gcccaaatcc      660

tgcgacaaga cacacacctg tcccccctgt cctgctcccg aactcctcgg aggccctagc      720

gtcttcctct ttcctcccaa acccaaggac accctcatga tcagcagaac ccctgaagtc      780

acctgtgtcg tcgtggatgt cagccatgag gaccccgagg tgaaattcaa ctggtatgtc      840

gatggcgtcg aggtgcacaa cgccaaaacc aagcccaggg aggaacagta caactccacc      900

tacagggtgg tgtccgtgct gacagtcctc caccaggact ggctgaacgg caaggagtac      960

aagtgcaagg tgtccaacaa ggctctccct gcccccattg agaagaccat cagcaaggcc     1020

aaaggccaac ccagggagcc ccaggtctat acactgcctc cctccaggga cgaactcacc     1080

aagaaccagg tgtccctgac ctgcctggtc aagggctttt atcccagcga catcgccgtc     1140

gagtgggagt ccaacggaca gcccgagaat aactacaaga ccacccctcc tgtcctcgac     1200

tccgacggct ccttcttcct gtacagcaag ctgaccgtgg acaaaagcag gtggcagcag     1260

ggaaacgtgt tctcctgcag cgtgatgcac gaagccctcc acaaccacta cacccagaaa     1320

agcctgtccc tgagccccgg caaa                                            1344


<210>  15
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain of 14C12H1L1

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Phe Thr Cys Arg Ala Ser Gln Asp Ile Asn Thr Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Met Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  16
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lnucleic acid encoding ight chain of 14C12H1L1

<400>  16
gacattcaga tgactcagag cccctcctcc atgtccgcct ctgtgggcga cagggtcacc       60

ttcacatgcc gcgctagtca ggatatcaac acctacctga gctggtttca gcagaagcca      120

gggaaaagcc ccaagacact gatctaccgg gctaatagac tggtgtctgg agtcccaagt      180

cggttcagtg gctcagggag cggacaggac tacactctga ccatcagctc cctgcagcct      240

gaggacatgg caacctacta ttgcctgcag tatgatgagt tcccactgac ctttggcgcc      300

gggacaaaac tggagctgaa gcgaactgtg gccgctccct ccgtcttcat ttttccccct      360

tctgacgaac agctgaaatc aggcacagcc agcgtggtct gtctgctgaa caatttctac      420

cctagagagg caaaagtgca gtggaaggtc gataacgccc tgcagtccgg caacagccag      480

gagagtgtga ctgaacagga ctcaaaagat agcacctatt ccctgtctag tacactgact      540

ctgtccaagg ctgattacga gaagcacaaa gtgtatgcat gcgaagtgac acatcaggga      600

ctgtcaagcc ccgtgactaa gtcttttaac cggggcgaat gt                         642


<210>  17
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain of 14C12H1L1(M)1

<400>  17

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Phe Thr Cys Arg Ala Ser Gln Asp Ile Asn Thr Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Met Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210>  18
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 1

<400>  18

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  19
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker 2

<400>  19

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  20
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bevacizumab-G4H

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Pro His Tyr Tyr Gly Ser Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  21
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid encoding Bevacizumab-G4H

<400>  21
gaggtgcagc tggtcgagtc cggggggggg ctggtgcagc caggcgggtc tctgaggctg       60

agttgcgccg cttcagggta caccttcaca aactatggaa tgaattgggt gcgccaggca      120

ccaggaaagg gactggagtg ggtcggctgg atcaacactt acaccgggga acctacctat      180

gcagccgact ttaagcggcg gttcaccttc agcctggata caagcaaatc cactgcctac      240

ctgcagatga acagcctgcg agctgaggac accgcagtct actattgtgc taaatatccc      300

cactactatg ggagcagcca ttggtatttt gacgtgtggg ggcaggggac tctggtgaca      360

gtgagcagcg caagcaccaa agggcccagc gtgtttcctc tcgccccctc ctccaaaagc      420

accagcggag gaaccgctgc tctcggatgt ctggtgaagg actacttccc tgaacccgtc      480

accgtgagct ggaatagcgg cgctctgaca agcggagtcc atacattccc tgctgtgctg      540

caaagcagcg gactctattc cctgtccagc gtcgtcacag tgcccagcag cagcctgggc      600

acccagacct acatctgtaa cgtcaaccac aagccctcca acaccaaggt ggacaagaaa      660

gtggagccca aatcctgcga caagacacac acctgtcccc cctgtcctgc tcccgaactc      720

ctcggaggcc ctagcgtctt cctctttcct cccaaaccca aggacaccct catgatcagc      780

agaacccctg aagtcacctg tgtcgtcgtg gatgtcagcc atgaggaccc cgaggtgaaa      840

ttcaactggt atgtcgatgg cgtcgaggtg cacaacgcca aaaccaagcc cagggaggaa      900

cagtacaact ccacctacag ggtggtgtcc gtgctgacag tcctccacca ggactggctg      960

aacggcaagg agtacaagtg caaggtgtcc aacaaggctc tccctgcccc cattgagaag     1020

accatcagca aggccaaagg ccaacccagg gagccccagg tctatacact gcctccctcc     1080

agggacgaac tcaccaagaa ccaggtgtcc ctgacctgcc tggtcaaggg cttttatccc     1140

agcgacatcg ccgtcgagtg ggagtccaac ggacagcccg agaataacta caagaccacc     1200

cctcctgtcc tcgactccga cggctccttc ttcctgtaca gcaaactgac cgtcgataaa     1260

tctaggtggc agcagggcaa cgtgttctct tgttccgtga tgcatgaagc actgcacaac     1320

cattataccc agaagtctct gagcctgtcc cccggcaag                            1359


<210>  22
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain of VP101(hG4WT)

<400>  22

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Pro His Tyr Tyr Gly Ser Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
        195                 200                 205             


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
    210                 215                 220                 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
        435                 440                 445             


Gly Lys 
    450 


<210>  23
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid encoding heavy chain of VP101(hG4WT)

<400>  23
gaggtgcagc tggtcgagtc cggggggggg ctggtgcagc caggcgggtc tctgaggctg       60

agttgcgccg cttcagggta caccttcaca aactatggaa tgaattgggt gcgccaggca      120

ccaggaaagg gactggagtg ggtcggctgg atcaacactt acaccgggga acctacctat      180

gcagccgact ttaagcggcg gttcaccttc agcctggata caagcaaatc cactgcctac      240

ctgcagatga acagcctgcg agctgaggac accgcagtct actattgtgc taaatatccc      300

cactactatg ggagcagcca ttggtatttt gacgtgtggg ggcaggggac tctggtgaca      360

gtgagcagcg caagcaccaa agggccctcg gtcttccccc tggcgccctg ctccaggagc      420

acctccgaga gcacagccgc cctgggctgc ctggtcaagg actacttccc cgaaccggtg      480

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      540

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc      600

acgaagacct acacctgcaa cgtagatcac aagcccagca acaccaaggt ggacaagaga      660

gttgagtcca aatatggtcc cccatgccca ccatgcccag cacctgagtt cctgggggga      720

ccatcagtct tcctgttccc cccaaaaccc aaggacactc tcatgatctc ccggacccct      780

gaggtcacgt gcgtggtggt ggacgtgagc caggaagacc ccgaggtcca gttcaactgg      840

tacgtggatg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagttcaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaacggcaag      960

gagtacaagt gcaaggtctc caacaaaggc ctcccgtcct ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agagccacag gtgtacaccc tgcccccatc ccaggaggag     1080

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctaccc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaggctaa ccgtggacaa gagcaggtgg     1260

caggagggga atgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacaca     1320

cagaagtctc tgagcctgtc cctcggcaag                                      1350


<210>  24
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunoglobulin heavy  chain of VP101(hG1DM)

<400>  24

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Pro His Tyr Tyr Gly Ser Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
225                 230                 235                 240 


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  25
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid encoding Immunoglobulin heavy  chain of VP101(hG1DM)

<400>  25
gaggtgcagc tggtcgagtc cggggggggg ctggtgcagc caggcgggtc tctgaggctg       60

agttgcgccg cttcagggta caccttcaca aactatggaa tgaattgggt gcgccaggca      120

ccaggaaagg gactggagtg ggtcggctgg atcaacactt acaccgggga acctacctat      180

gcagccgact ttaagcggcg gttcaccttc agcctggata caagcaaatc cactgcctac      240

ctgcagatga acagcctgcg agctgaggac accgcagtct actattgtgc taaatatccc      300

cactactatg ggagcagcca ttggtatttt gacgtgtggg ggcaggggac tctggtgaca      360

gtgagcagcg caagcaccaa agggcccagc gtgtttcctc tcgccccctc ctccaaaagc      420

accagcggag gaaccgctgc tctcggatgt ctggtgaagg actacttccc tgaacccgtc      480

accgtgagct ggaatagcgg cgctctgaca agcggagtcc atacattccc tgctgtgctg      540

caaagcagcg gactctattc cctgtccagc gtcgtcacag tgcccagcag cagcctgggc      600

acccagacct acatctgtaa cgtcaaccac aagccctcca acaccaaggt ggacaagaaa      660

gtggagccca aatcctgcga caagacacac acctgtcccc cctgtcctgc tcccgaagct      720

gctggaggcc ctagcgtctt cctctttcct cccaaaccca aggacaccct catgatcagc      780

agaacccctg aagtcacctg tgtcgtcgtg gatgtcagcc atgaggaccc cgaggtgaaa      840

ttcaactggt atgtcgatgg cgtcgaggtg cacaacgcca aaaccaagcc cagggaggaa      900

cagtacaact ccacctacag ggtggtgtcc gtgctgacag tcctccacca ggactggctg      960

aacggcaagg agtacaagtg caaggtgtcc aacaaggctc tccctgcccc cattgagaag     1020

accatcagca aggccaaagg ccaacccagg gagccccagg tctatacact gcctccctcc     1080

agggacgaac tcaccaagaa ccaggtgtcc ctgacctgcc tggtcaaggg cttttatccc     1140

agcgacatcg ccgtcgagtg ggagtccaac ggacagcccg agaataacta caagaccacc     1200

cctcctgtcc tcgactccga cggctccttc ttcctgtaca gcaaactgac cgtcgataaa     1260

tctaggtggc agcagggcaa cgtgttctct tgttccgtga tgcatgaagc actgcacaac     1320

cattataccc agaagtctct gagcctgtcc cccggcaag                            1359


<210>  26
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunoglobulin light chain of VP101(hG1DM)

<400>  26

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  27
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid encoding Immunoglobulin light chain of VP101(hG1DM)

<400>  27
gatattcaga tgactcagag cccctcctcc ctgtccgcct ctgtgggcga cagggtcacc       60

atcacatgca gtgcttcaca ggatatttcc aactacctga attggtatca gcagaagcca      120

ggaaaagcac ccaaggtgct gatctacttc actagctccc tgcactcagg agtgccaagc      180

cggttcagcg gatccggatc tggaaccgac tttactctga ccatttctag tctgcagcct      240

gaggatttcg ctacatacta ttgccagcag tattctaccg tgccatggac atttggccag      300

gggactaaag tcgagatcaa gcggaccgtg gccgctccca gtgtcttcat ttttccccct      360

agcgacgaac agctgaaatc cgggacagcc tctgtggtct gtctgctgaa caacttctac      420

cctagagagg caaaagtgca gtggaaggtc gataacgccc tgcagagtgg caattcacag      480

gagagcgtga cagaacagga ctccaaagat tctacttata gtctgtcaag cacactgact      540

ctgagcaagg ctgactacga aaagcataaa gtgtatgcat gtgaggtcac ccaccagggg      600

ctgagcagtc cagtcaccaa gtcattcaac agaggcgagt gc                         642


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1

<400>  28

Gly Tyr Thr Phe Thr Asn Tyr Gly 
1               5               


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  29

Ile Asn Thr Tyr Thr Gly Glu Pro 
1               5               


<210>  30
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3

<400>  30

Ala Lys Tyr Pro His Tyr Tyr Gly Ser Ser His Trp Tyr Phe Asp Val 
1               5                   10                  15      


<210>  31
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1

<400>  31

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  32
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2

<400>  32

Phe Thr Ser 
1           


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  33

Gln Gln Tyr Ser Thr Val Pro Trp Thr 
1               5                   


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1

<400>  34

Gly Phe Ala Phe Ser Ser Tyr Asp 
1               5               


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  35

Ile Ser Gly Gly Gly Arg Tyr Thr 
1               5               


<210>  36
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3

<400>  36

Ala Asn Arg Tyr Gly Glu Ala Trp Phe Ala Tyr 
1               5                   10      


<210>  37
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1

<400>  37

Gln Asp Ile Asn Thr Tyr 
1               5       


<210>  38
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2

<400>  38

Arg Ala Asn 
1           


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  39

Leu Gln Tyr Asp Glu Phe Pro Leu Thr 
1               5                   


<210>  40
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ig gamma-1 chain C region

<400>  40

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  41
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ig gamma-4 chain C region

<400>  41

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  42
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ig kappa chain C region

<400>  42

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


