                         б

<110>  Ϻʮҽѧѧо
 
<120>  ĽCG༭ϵͳ

<130>  P2022TC1988

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOBEC3A

<400>  1

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn 
        195                 


<210>  2
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN linker

<400>  2

Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
1               5                   10                  15      


<210>  3
<211>  1367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nCas9 (D10A)

<400>  3

Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
            20                  25                  30          


Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
        35                  40                  45              


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
    50                  55                  60                  


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
65                  70                  75                  80  


Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
                85                  90                  95      


Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
            100                 105                 110         


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
        115                 120                 125             


Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
    130                 135                 140                 


Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
145                 150                 155                 160 


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
                165                 170                 175     


Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
            180                 185                 190         


Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
        195                 200                 205             


Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
    210                 215                 220                 


Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
225                 230                 235                 240 


Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
                245                 250                 255     


Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
            260                 265                 270         


Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
        275                 280                 285             


Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
    290                 295                 300                 


Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
305                 310                 315                 320 


Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
                325                 330                 335     


Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
            340                 345                 350         


Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
        355                 360                 365             


Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly 
    370                 375                 380                 


Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys 
385                 390                 395                 400 


Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly 
                405                 410                 415     


Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu 
            420                 425                 430         


Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro 
        435                 440                 445             


Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met 
    450                 455                 460                 


Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val 
465                 470                 475                 480 


Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn 
                485                 490                 495     


Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu 
            500                 505                 510         


Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr 
        515                 520                 525             


Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys 
    530                 535                 540                 


Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val 
545                 550                 555                 560 


Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser 
                565                 570                 575     


Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His 
625                 630                 635                 640 


Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys 
    690                 695                 700                 


Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His 
705                 710                 715                 720 


Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1355                 1360                 1365         


<210>  4
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nucleoplasmin NLS

<400>  4

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  5
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E-coil UDG

<400>  5

Ala Asn Glu Leu Thr Trp His Asp Val Leu Ala Glu Glu Lys Gln Gln 
1               5                   10                  15      


Pro Tyr Phe Leu Asn Thr Leu Gln Thr Val Ala Ser Glu Arg Gln Ser 
            20                  25                  30          


Gly Val Thr Ile Tyr Pro Pro Gln Lys Asp Val Phe Asn Ala Phe Arg 
        35                  40                  45              


Phe Thr Glu Leu Gly Asp Val Lys Val Val Ile Leu Gly Gln Asp Pro 
    50                  55                  60                  


Tyr His Gly Pro Gly Gln Ala His Gly Leu Ala Phe Ser Val Arg Pro 
65                  70                  75                  80  


Gly Ile Ala Ile Pro Pro Ser Leu Leu Asn Met Tyr Lys Glu Leu Glu 
                85                  90                  95      


Asn Thr Ile Pro Gly Phe Thr Arg Pro Asn His Gly Tyr Leu Glu Ser 
            100                 105                 110         


Trp Ala Arg Gln Gly Val Leu Leu Leu Asn Thr Val Leu Thr Val Arg 
        115                 120                 125             


Ala Gly Gln Ala His Ser His Ala Ser Leu Gly Trp Glu Thr Phe Thr 
    130                 135                 140                 


Asp Lys Val Ile Ser Leu Ile Asn Gln His Arg Glu Gly Val Val Phe 
145                 150                 155                 160 


Leu Leu Trp Gly Ser His Ala Gln Lys Lys Gly Ala Ile Ile Asp Lys 
                165                 170                 175     


Gln Arg His His Val Leu Lys Ala Pro His Pro Ser Pro Leu Ser Ala 
            180                 185                 190         


His Arg Gly Phe Phe Gly Cys Asn His Phe Val Leu Ala Asn Gln Trp 
        195                 200                 205             


Leu Glu Gln Arg Gly Glu Thr Pro Ile Asp Trp Met Pro Val Leu Pro 
    210                 215                 220                 


Ala Glu Ser Glu 
225             


<210>  6
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A linker

<400>  6

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  7
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MCP

<400>  7

Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr Gly 
1               5                   10                  15      


Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Ile Ala Glu Trp 
            20                  25                  30          


Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser Val 
        35                  40                  45              


Arg Gln Ser Ser Ala Gln Asn Arg Lys Tyr Thr Ile Lys Val Glu Val 
    50                  55                  60                  


Pro Lys Gly Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro 
65                  70                  75                  80  


Ile Phe Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln 
                85                  90                  95      


Gly Leu Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn 
            100                 105                 110         


Ser Gly Ile Tyr 
        115     


<210>  8
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SV40 NLS

<400>  8

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  9
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OsPCNA (K164R)

<400>  9

Met Leu Glu Leu Arg Leu Val Gln Gly Ser Leu Leu Lys Lys Val Leu 
1               5                   10                  15      


Glu Ala Ile Arg Glu Leu Val Thr Asp Ala Asn Phe Asp Cys Ser Gly 
            20                  25                  30          


Thr Gly Phe Ser Leu Gln Ala Met Asp Ser Ser His Val Ala Leu Val 
        35                  40                  45              


Ala Leu Leu Leu Arg Ser Glu Gly Phe Glu His Tyr Arg Cys Asp Arg 
    50                  55                  60                  


Asn Leu Ser Met Gly Met Asn Leu Asn Asn Met Ala Lys Met Leu Arg 
65                  70                  75                  80  


Cys Ala Gly Asn Asp Asp Ile Ile Thr Ile Lys Ala Asp Asp Gly Ser 
                85                  90                  95      


Asp Thr Val Thr Phe Met Phe Glu Ser Pro Asn Gln Asp Lys Ile Ala 
            100                 105                 110         


Asp Phe Glu Met Lys Leu Met Asp Ile Asp Ser Glu His Leu Gly Ile 
        115                 120                 125             


Pro Asp Ser Glu Tyr Gln Ala Ile Val Arg Met Pro Ser Ser Glu Phe 
    130                 135                 140                 


Ser Arg Ile Cys Lys Asp Leu Ser Ser Ile Gly Asp Thr Val Ile Ile 
145                 150                 155                 160 


Ser Val Thr Arg Glu Gly Val Lys Phe Ser Thr Ala Gly Asp Ile Gly 
                165                 170                 175     


Thr Ala Asn Ile Val Cys Arg Gln Asn Lys Thr Val Asp Lys Pro Glu 
            180                 185                 190         


Asp Ala Thr Ile Ile Glu Met Gln Glu Pro Val Ser Leu Thr Phe Ala 
        195                 200                 205             


Leu Arg Tyr Met Asn Ser Phe Thr Lys Ala Ser Pro Leu Ser Glu Gln 
    210                 215                 220                 


Val Thr Ile Ser Leu Ser Ser Glu Leu Pro Val Val Val Glu Tyr Lys 
225                 230                 235                 240 


Ile Ala Glu Met Gly Tyr Ile Arg Phe Tyr Leu Ala Pro Lys Ile Glu 
                245                 250                 255     


Glu Asp Glu Glu Met Lys Ser 
            260             


<210>  10
<211>  74
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated Ubiquitin (Ub)

<400>  10

Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Ser Ser Asp Thr Ile Asp Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ala Asp Tyr Asn Ile Gln Lys Glu 
    50                  55                  60                  


Ser Thr Leu His Leu Val Leu Arg Leu Arg 
65                  70                  


<210>  11
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OsAPE (D238A/N240V), dAPE

<400>  11

Met Lys Arg Phe Phe Gln Pro Val Pro Lys Asp Gly Ser Pro Ala Lys 
1               5                   10                  15      


Lys Arg Pro Ala Ala Ala Ala Ala Ala Ser Ala Ser Asp Ser Asp Ser 
            20                  25                  30          


Leu Gly Gly Asp Ala Pro Ala Ala Ala Ala Cys Ala Val Gly Glu Gly 
        35                  40                  45              


Asp Ser Pro Pro Ala Pro Arg Glu Glu Glu Pro Arg Arg Phe Val Thr 
    50                  55                  60                  


Trp Asn Ala Asn Ser Leu Leu Leu Arg Met Lys Ser Asp Trp Pro Ala 
65                  70                  75                  80  


Phe Cys Gln Phe Val Ser Arg Val Asp Pro Asp Val Ile Cys Val Gln 
                85                  90                  95      


Glu Val Arg Met Pro Ala Ala Gly Ser Lys Gly Ala Pro Lys Asn Pro 
            100                 105                 110         


Gly Gln Leu Lys Asp Asp Thr Ser Ser Ser Arg Asp Glu Lys Gln Val 
        115                 120                 125             


Val Leu Arg Ala Leu Ser Ser Pro Pro Phe Lys Asp Tyr Arg Val Trp 
    130                 135                 140                 


Trp Ser Leu Ser Asp Ser Lys Tyr Ala Gly Thr Ala Met Ile Ile Lys 
145                 150                 155                 160 


Lys Lys Phe Glu Pro Lys Lys Val Ser Phe Asn Leu Asp Arg Thr Ser 
                165                 170                 175     


Ser Lys His Glu Pro Asp Gly Arg Val Ile Ile Ala Glu Phe Glu Ser 
            180                 185                 190         


Phe Leu Leu Leu Asn Thr Tyr Ala Pro Asn Asn Gly Trp Lys Glu Glu 
        195                 200                 205             


Glu Asn Ser Phe Gln Arg Arg Arg Lys Trp Asp Lys Arg Met Leu Glu 
    210                 215                 220                 


Phe Val Gln Gln Val Asp Lys Pro Leu Ile Trp Cys Gly Ala Leu Val 
225                 230                 235                 240 


Val Ser His Glu Glu Ile Asp Val Ser His Pro Asp Phe Phe Ser Ser 
                245                 250                 255     


Ala Lys Leu Asn Gly Tyr Ile Pro Pro Asn Lys Glu Asp Cys Gly Gln 
            260                 265                 270         


Pro Gly Phe Thr Leu Ser Glu Arg Arg Arg Phe Gly Asn Ile Leu Ser 
        275                 280                 285             


Gln Gly Lys Leu Val Asp Ala Tyr Arg Tyr Leu His Lys Glu Lys Asp 
    290                 295                 300                 


Met Asp Cys Gly Phe Ser Trp Ser Gly His Pro Ile Gly Lys Tyr Arg 
305                 310                 315                 320 


Gly Lys Arg Met Arg Ile Asp Tyr Phe Leu Val Ser Glu Lys Leu Lys 
                325                 330                 335     


Asp Gln Ile Val Ser Cys Asp Ile His Gly Arg Gly Ile Glu Leu Glu 
            340                 345                 350         


Gly Phe Tyr Gly Ser Asp His Cys Pro Val Ser Leu Glu Leu Ser Glu 
        355                 360                 365             


Glu Val Glu Ala Pro Lys Pro Lys Ser Ser Asn 
    370                 375                 


<210>  12
<211>  1842
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PCGBE-1ϵͳʾԶ

<400>  12

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn Ser Gly Ser Glu Thr Pro Gly Thr Ser 
        195                 200                 205             


Glu Ser Ala Thr Pro Glu Ser Arg Pro Asp Lys Lys Tyr Ser Ile Gly 
    210                 215                 220                 


Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
225                 230                 235                 240 


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
                245                 250                 255     


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
            260                 265                 270         


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
        275                 280                 285             


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
    290                 295                 300                 


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
305                 310                 315                 320 


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
                325                 330                 335     


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
            340                 345                 350         


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
        355                 360                 365             


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
    370                 375                 380                 


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
385                 390                 395                 400 


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
                405                 410                 415     


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
            420                 425                 430         


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
        435                 440                 445             


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
    450                 455                 460                 


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
465                 470                 475                 480 


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
                485                 490                 495     


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
            500                 505                 510         


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
        515                 520                 525             


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
    530                 535                 540                 


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
545                 550                 555                 560 


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
                565                 570                 575     


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
            580                 585                 590         


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
        595                 600                 605             


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
    610                 615                 620                 


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
625                 630                 635                 640 


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
                645                 650                 655     


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
            660                 665                 670         


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
        675                 680                 685             


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
    690                 695                 700                 


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
705                 710                 715                 720 


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
                725                 730                 735     


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
            740                 745                 750         


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
        755                 760                 765             


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
    770                 775                 780                 


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
785                 790                 795                 800 


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
                805                 810                 815     


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
            820                 825                 830         


Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile 
        835                 840                 845             


Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met 
    850                 855                 860                 


Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg 
865                 870                 875                 880 


Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu 
                885                 890                 895     


Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu 
            900                 905                 910         


Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln 
        915                 920                 925             


Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala 
    930                 935                 940                 


Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val 
945                 950                 955                 960 


Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val 
                965                 970                 975     


Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn 
            980                 985                 990         


Ser Arg Glu Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
        995                 1000                 1005             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1010                 1015                 1020             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1025                 1030                 1035             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1040                 1045                 1050             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1055                 1060                 1065             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1070                 1075                 1080             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1085                 1090                 1095             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1100                 1105                 1110             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1115                 1120                 1125             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1130                 1135                 1140             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1145                 1150                 1155             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1160                 1165                 1170             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1175                 1180                 1185             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1190                 1195                 1200             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1205                 1210                 1215             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1220                 1225                 1230             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1235                 1240                 1245             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1250                 1255                 1260             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1265                 1270                 1275             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1280                 1285                 1290             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1295                 1300                 1305             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1310                 1315                 1320             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1325                 1330                 1335             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1340                 1345                 1350             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1355                 1360                 1365             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1370                 1375                 1380             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1385                 1390                 1395             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1400                 1405                 1410             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1415                 1420                 1425             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1430                 1435                 1440             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1445                 1450                 1455             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1460                 1465                 1470             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1475                 1480                 1485             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1490                 1495                 1500             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1505                 1510                 1515             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1520                 1525                 1530             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1535                 1540                 1545             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1550                 1555                 1560             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1565                 1570                 1575             


Ser Gln  Leu Gly Gly Asp Lys  Arg Pro Ala Ala Thr  Lys Lys Ala 
    1580                 1585                 1590             


Gly Gln  Ala Lys Lys Lys Lys  Gly Thr Asp Ser Gly  Gly Ser Ala 
    1595                 1600                 1605             


Asn Glu  Leu Thr Trp His Asp  Val Leu Ala Glu Glu  Lys Gln Gln 
    1610                 1615                 1620             


Pro Tyr  Phe Leu Asn Thr Leu  Gln Thr Val Ala Ser  Glu Arg Gln 
    1625                 1630                 1635             


Ser Gly  Val Thr Ile Tyr Pro  Pro Gln Lys Asp Val  Phe Asn Ala 
    1640                 1645                 1650             


Phe Arg  Phe Thr Glu Leu Gly  Asp Val Lys Val Val  Ile Leu Gly 
    1655                 1660                 1665             


Gln Asp  Pro Tyr His Gly Pro  Gly Gln Ala His Gly  Leu Ala Phe 
    1670                 1675                 1680             


Ser Val  Arg Pro Gly Ile Ala  Ile Pro Pro Ser Leu  Leu Asn Met 
    1685                 1690                 1695             


Tyr Lys  Glu Leu Glu Asn Thr  Ile Pro Gly Phe Thr  Arg Pro Asn 
    1700                 1705                 1710             


His Gly  Tyr Leu Glu Ser Trp  Ala Arg Gln Gly Val  Leu Leu Leu 
    1715                 1720                 1725             


Asn Thr  Val Leu Thr Val Arg  Ala Gly Gln Ala His  Ser His Ala 
    1730                 1735                 1740             


Ser Leu  Gly Trp Glu Thr Phe  Thr Asp Lys Val Ile  Ser Leu Ile 
    1745                 1750                 1755             


Asn Gln  His Arg Glu Gly Val  Val Phe Leu Leu Trp  Gly Ser His 
    1760                 1765                 1770             


Ala Gln  Lys Lys Gly Ala Ile  Ile Asp Lys Gln Arg  His His Val 
    1775                 1780                 1785             


Leu Lys  Ala Pro His Pro Ser  Pro Leu Ser Ala His  Arg Gly Phe 
    1790                 1795                 1800             


Phe Gly  Cys Asn His Phe Val  Leu Ala Asn Gln Trp  Leu Glu Gln 
    1805                 1810                 1815             


Arg Gly  Glu Thr Pro Ile Asp  Trp Met Pro Val Leu  Pro Ala Glu 
    1820                 1825                 1830             


Ser Glu  Pro Lys Lys Lys Arg  Lys Val 
    1835                 1840         


<210>  13
<211>  2358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PCGBEϵͳʾ(ͼ11b)

<400>  13

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn Ser Gly Ser Glu Thr Pro Gly Thr Ser 
        195                 200                 205             


Glu Ser Ala Thr Pro Glu Ser Leu Lys Asp Lys Lys Tyr Ser Ile Gly 
    210                 215                 220                 


Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
225                 230                 235                 240 


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
                245                 250                 255     


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
            260                 265                 270         


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
        275                 280                 285             


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
    290                 295                 300                 


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
305                 310                 315                 320 


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
                325                 330                 335     


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
            340                 345                 350         


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
        355                 360                 365             


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
    370                 375                 380                 


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
385                 390                 395                 400 


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
                405                 410                 415     


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
            420                 425                 430         


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
        435                 440                 445             


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
    450                 455                 460                 


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
465                 470                 475                 480 


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
                485                 490                 495     


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
            500                 505                 510         


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
        515                 520                 525             


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
    530                 535                 540                 


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
545                 550                 555                 560 


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
                565                 570                 575     


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
            580                 585                 590         


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
        595                 600                 605             


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
    610                 615                 620                 


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
625                 630                 635                 640 


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
                645                 650                 655     


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
            660                 665                 670         


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
        675                 680                 685             


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
    690                 695                 700                 


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
705                 710                 715                 720 


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
                725                 730                 735     


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
            740                 745                 750         


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
        755                 760                 765             


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
    770                 775                 780                 


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
785                 790                 795                 800 


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
                805                 810                 815     


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
            820                 825                 830         


Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile 
        835                 840                 845             


Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met 
    850                 855                 860                 


Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg 
865                 870                 875                 880 


Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu 
                885                 890                 895     


Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu 
            900                 905                 910         


Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln 
        915                 920                 925             


Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala 
    930                 935                 940                 


Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val 
945                 950                 955                 960 


Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val 
                965                 970                 975     


Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn 
            980                 985                 990         


Ser Arg Glu Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
        995                 1000                 1005             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1010                 1015                 1020             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1025                 1030                 1035             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1040                 1045                 1050             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1055                 1060                 1065             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1070                 1075                 1080             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1085                 1090                 1095             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1100                 1105                 1110             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1115                 1120                 1125             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1130                 1135                 1140             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1145                 1150                 1155             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1160                 1165                 1170             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1175                 1180                 1185             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1190                 1195                 1200             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1205                 1210                 1215             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1220                 1225                 1230             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1235                 1240                 1245             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1250                 1255                 1260             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1265                 1270                 1275             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1280                 1285                 1290             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1295                 1300                 1305             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1310                 1315                 1320             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1325                 1330                 1335             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1340                 1345                 1350             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1355                 1360                 1365             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1370                 1375                 1380             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1385                 1390                 1395             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1400                 1405                 1410             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1415                 1420                 1425             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1430                 1435                 1440             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1445                 1450                 1455             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1460                 1465                 1470             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1475                 1480                 1485             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1490                 1495                 1500             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1505                 1510                 1515             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1520                 1525                 1530             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1535                 1540                 1545             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1550                 1555                 1560             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1565                 1570                 1575             


Ser Gln  Leu Gly Gly Asp Lys  Arg Pro Ala Ala Thr  Lys Lys Ala 
    1580                 1585                 1590             


Gly Gln  Ala Lys Lys Lys Lys  Thr Arg Asp Ser Gly  Gly Ser Ala 
    1595                 1600                 1605             


Asn Glu  Leu Thr Trp His Asp  Val Leu Ala Glu Glu  Lys Gln Gln 
    1610                 1615                 1620             


Pro Tyr  Phe Leu Asn Thr Leu  Gln Thr Val Ala Ser  Glu Arg Gln 
    1625                 1630                 1635             


Ser Gly  Val Thr Ile Tyr Pro  Pro Gln Lys Asp Val  Phe Asn Ala 
    1640                 1645                 1650             


Phe Arg  Phe Thr Glu Leu Gly  Asp Val Lys Val Val  Ile Leu Gly 
    1655                 1660                 1665             


Gln Asp  Pro Tyr His Gly Pro  Gly Gln Ala His Gly  Leu Ala Phe 
    1670                 1675                 1680             


Ser Val  Arg Pro Gly Ile Ala  Ile Pro Pro Ser Leu  Leu Asn Met 
    1685                 1690                 1695             


Tyr Lys  Glu Leu Glu Asn Thr  Ile Pro Gly Phe Thr  Arg Pro Asn 
    1700                 1705                 1710             


His Gly  Tyr Leu Glu Ser Trp  Ala Arg Gln Gly Val  Leu Leu Leu 
    1715                 1720                 1725             


Asn Thr  Val Leu Thr Val Arg  Ala Gly Gln Ala His  Ser His Ala 
    1730                 1735                 1740             


Ser Leu  Gly Trp Glu Thr Phe  Thr Asp Lys Val Ile  Ser Leu Ile 
    1745                 1750                 1755             


Asn Gln  His Arg Glu Gly Val  Val Phe Leu Leu Trp  Gly Ser His 
    1760                 1765                 1770             


Ala Gln  Lys Lys Gly Ala Ile  Ile Asp Lys Gln Arg  His His Val 
    1775                 1780                 1785             


Leu Lys  Ala Pro His Pro Ser  Pro Leu Ser Ala His  Arg Gly Phe 
    1790                 1795                 1800             


Phe Gly  Cys Asn His Phe Val  Leu Ala Asn Gln Trp  Leu Glu Gln 
    1805                 1810                 1815             


Arg Gly  Glu Thr Pro Ile Asp  Trp Met Pro Val Leu  Pro Ala Glu 
    1820                 1825                 1830             


Ser Glu  Pro Lys Lys Lys Arg  Lys Val Ser Ala Glu  Gly Arg Gly 
    1835                 1840                 1845             


Ser Leu  Leu Thr Cys Gly Asp  Val Glu Glu Asn Pro  Gly Pro Ala 
    1850                 1855                 1860             


Ser Asn  Phe Thr Gln Phe Val  Leu Val Asp Asn Gly  Gly Thr Gly 
    1865                 1870                 1875             


Asp Val  Thr Val Ala Pro Ser  Asn Phe Ala Asn Gly  Ile Ala Glu 
    1880                 1885                 1890             


Trp Ile  Ser Ser Asn Ser Arg  Ser Gln Ala Tyr Lys  Val Thr Cys 
    1895                 1900                 1905             


Ser Val  Arg Gln Ser Ser Ala  Gln Asn Arg Lys Tyr  Thr Ile Lys 
    1910                 1915                 1920             


Val Glu  Val Pro Lys Gly Ala  Trp Arg Ser Tyr Leu  Asn Met Glu 
    1925                 1930                 1935             


Leu Thr  Ile Pro Ile Phe Ala  Thr Asn Ser Asp Cys  Glu Leu Ile 
    1940                 1945                 1950             


Val Lys  Ala Met Gln Gly Leu  Leu Lys Asp Gly Asn  Pro Ile Pro 
    1955                 1960                 1965             


Ser Ala  Ile Ala Ala Asn Ser  Gly Ile Tyr Gly Gly  Ser Pro Lys 
    1970                 1975                 1980             


Lys Lys  Arg Lys Val Ser Gly  Ser Glu Thr Pro Gly  Thr Ser Glu 
    1985                 1990                 1995             


Ser Ala  Thr Pro Glu Ser Pro  Arg Met Leu Glu Leu  Arg Leu Val 
    2000                 2005                 2010             


Gln Gly  Ser Leu Leu Lys Lys  Val Leu Glu Ala Ile  Arg Glu Leu 
    2015                 2020                 2025             


Val Thr  Asp Ala Asn Phe Asp  Cys Ser Gly Thr Gly  Phe Ser Leu 
    2030                 2035                 2040             


Gln Ala  Met Asp Ser Ser His  Val Ala Leu Val Ala  Leu Leu Leu 
    2045                 2050                 2055             


Arg Ser  Glu Gly Phe Glu His  Tyr Arg Cys Asp Arg  Asn Leu Ser 
    2060                 2065                 2070             


Met Gly  Met Asn Leu Asn Asn  Met Ala Lys Met Leu  Arg Cys Ala 
    2075                 2080                 2085             


Gly Asn  Asp Asp Ile Ile Thr  Ile Lys Ala Asp Asp  Gly Ser Asp 
    2090                 2095                 2100             


Thr Val  Thr Phe Met Phe Glu  Ser Pro Asn Gln Asp  Lys Ile Ala 
    2105                 2110                 2115             


Asp Phe  Glu Met Lys Leu Met  Asp Ile Asp Ser Glu  His Leu Gly 
    2120                 2125                 2130             


Ile Pro  Asp Ser Glu Tyr Gln  Ala Ile Val Arg Met  Pro Ser Ser 
    2135                 2140                 2145             


Glu Phe  Ser Arg Ile Cys Lys  Asp Leu Ser Ser Ile  Gly Asp Thr 
    2150                 2155                 2160             


Val Ile  Ile Ser Val Thr Arg  Glu Gly Val Lys Phe  Ser Thr Ala 
    2165                 2170                 2175             


Gly Asp  Ile Gly Thr Ala Asn  Ile Val Cys Arg Gln  Asn Lys Thr 
    2180                 2185                 2190             


Val Asp  Lys Pro Glu Asp Ala  Thr Ile Ile Glu Met  Gln Glu Pro 
    2195                 2200                 2205             


Val Ser  Leu Thr Phe Ala Leu  Arg Tyr Met Asn Ser  Phe Thr Lys 
    2210                 2215                 2220             


Ala Ser  Pro Leu Ser Glu Gln  Val Thr Ile Ser Leu  Ser Ser Glu 
    2225                 2230                 2235             


Leu Pro  Val Val Val Glu Tyr  Lys Ile Ala Glu Met  Gly Tyr Ile 
    2240                 2245                 2250             


Arg Phe  Tyr Leu Ala Pro Lys  Ile Glu Glu Asp Glu  Glu Met Lys 
    2255                 2260                 2265             


Ser Ser  Gly Gly Ser Met Gln  Ile Phe Val Lys Thr  Leu Thr Gly 
    2270                 2275                 2280             


Lys Thr  Ile Thr Leu Glu Val  Glu Ser Ser Asp Thr  Ile Asp Asn 
    2285                 2290                 2295             


Val Lys  Ala Lys Ile Gln Asp  Lys Glu Gly Ile Pro  Pro Asp Gln 
    2300                 2305                 2310             


Gln Arg  Leu Ile Phe Ala Gly  Lys Gln Leu Glu Asp  Gly Arg Thr 
    2315                 2320                 2325             


Leu Ala  Asp Tyr Asn Ile Gln  Lys Glu Ser Thr Leu  His Leu Val 
    2330                 2335                 2340             


Leu Arg  Leu Arg Ser Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    2345                 2350                 2355             


<210>  14
<211>  2248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PCGBEϵͳʾ(ͼ11c)

<400>  14

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn Ser Gly Ser Glu Thr Pro Gly Thr Ser 
        195                 200                 205             


Glu Ser Ala Thr Pro Glu Ser Leu Lys Asp Lys Lys Tyr Ser Ile Gly 
    210                 215                 220                 


Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
225                 230                 235                 240 


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
                245                 250                 255     


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
            260                 265                 270         


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
        275                 280                 285             


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
    290                 295                 300                 


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
305                 310                 315                 320 


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
                325                 330                 335     


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
            340                 345                 350         


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
        355                 360                 365             


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
    370                 375                 380                 


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
385                 390                 395                 400 


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
                405                 410                 415     


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
            420                 425                 430         


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
        435                 440                 445             


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
    450                 455                 460                 


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
465                 470                 475                 480 


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
                485                 490                 495     


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
            500                 505                 510         


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
        515                 520                 525             


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
    530                 535                 540                 


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
545                 550                 555                 560 


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
                565                 570                 575     


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
            580                 585                 590         


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
        595                 600                 605             


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
    610                 615                 620                 


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
625                 630                 635                 640 


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
                645                 650                 655     


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
            660                 665                 670         


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
        675                 680                 685             


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
    690                 695                 700                 


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
705                 710                 715                 720 


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
                725                 730                 735     


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
            740                 745                 750         


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
        755                 760                 765             


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
    770                 775                 780                 


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
785                 790                 795                 800 


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
                805                 810                 815     


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
            820                 825                 830         


Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile 
        835                 840                 845             


Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met 
    850                 855                 860                 


Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg 
865                 870                 875                 880 


Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu 
                885                 890                 895     


Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu 
            900                 905                 910         


Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln 
        915                 920                 925             


Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala 
    930                 935                 940                 


Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val 
945                 950                 955                 960 


Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val 
                965                 970                 975     


Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn 
            980                 985                 990         


Ser Arg Glu Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
        995                 1000                 1005             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1010                 1015                 1020             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1025                 1030                 1035             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1040                 1045                 1050             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1055                 1060                 1065             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1070                 1075                 1080             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1085                 1090                 1095             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1100                 1105                 1110             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1115                 1120                 1125             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1130                 1135                 1140             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1145                 1150                 1155             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1160                 1165                 1170             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1175                 1180                 1185             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1190                 1195                 1200             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1205                 1210                 1215             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1220                 1225                 1230             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1235                 1240                 1245             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1250                 1255                 1260             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1265                 1270                 1275             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1280                 1285                 1290             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1295                 1300                 1305             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1310                 1315                 1320             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1325                 1330                 1335             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1340                 1345                 1350             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1355                 1360                 1365             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1370                 1375                 1380             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1385                 1390                 1395             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1400                 1405                 1410             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1415                 1420                 1425             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1430                 1435                 1440             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1445                 1450                 1455             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1460                 1465                 1470             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1475                 1480                 1485             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1490                 1495                 1500             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1505                 1510                 1515             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1520                 1525                 1530             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1535                 1540                 1545             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1550                 1555                 1560             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1565                 1570                 1575             


Ser Gln  Leu Gly Gly Asp Lys  Arg Pro Ala Ala Thr  Lys Lys Ala 
    1580                 1585                 1590             


Gly Gln  Ala Lys Lys Lys Lys  Thr Arg Asp Ser Gly  Gly Ser Ala 
    1595                 1600                 1605             


Asn Glu  Leu Thr Trp His Asp  Val Leu Ala Glu Glu  Lys Gln Gln 
    1610                 1615                 1620             


Pro Tyr  Phe Leu Asn Thr Leu  Gln Thr Val Ala Ser  Glu Arg Gln 
    1625                 1630                 1635             


Ser Gly  Val Thr Ile Tyr Pro  Pro Gln Lys Asp Val  Phe Asn Ala 
    1640                 1645                 1650             


Phe Arg  Phe Thr Glu Leu Gly  Asp Val Lys Val Val  Ile Leu Gly 
    1655                 1660                 1665             


Gln Asp  Pro Tyr His Gly Pro  Gly Gln Ala His Gly  Leu Ala Phe 
    1670                 1675                 1680             


Ser Val  Arg Pro Gly Ile Ala  Ile Pro Pro Ser Leu  Leu Asn Met 
    1685                 1690                 1695             


Tyr Lys  Glu Leu Glu Asn Thr  Ile Pro Gly Phe Thr  Arg Pro Asn 
    1700                 1705                 1710             


His Gly  Tyr Leu Glu Ser Trp  Ala Arg Gln Gly Val  Leu Leu Leu 
    1715                 1720                 1725             


Asn Thr  Val Leu Thr Val Arg  Ala Gly Gln Ala His  Ser His Ala 
    1730                 1735                 1740             


Ser Leu  Gly Trp Glu Thr Phe  Thr Asp Lys Val Ile  Ser Leu Ile 
    1745                 1750                 1755             


Asn Gln  His Arg Glu Gly Val  Val Phe Leu Leu Trp  Gly Ser His 
    1760                 1765                 1770             


Ala Gln  Lys Lys Gly Ala Ile  Ile Asp Lys Gln Arg  His His Val 
    1775                 1780                 1785             


Leu Lys  Ala Pro His Pro Ser  Pro Leu Ser Ala His  Arg Gly Phe 
    1790                 1795                 1800             


Phe Gly  Cys Asn His Phe Val  Leu Ala Asn Gln Trp  Leu Glu Gln 
    1805                 1810                 1815             


Arg Gly  Glu Thr Pro Ile Asp  Trp Met Pro Val Leu  Pro Ala Glu 
    1820                 1825                 1830             


Ser Glu  Pro Lys Lys Lys Arg  Lys Val Ser Ala Glu  Gly Arg Gly 
    1835                 1840                 1845             


Ser Leu  Leu Thr Cys Gly Asp  Val Glu Glu Asn Pro  Gly Pro Met 
    1850                 1855                 1860             


Lys Arg  Phe Phe Gln Pro Val  Pro Lys Asp Gly Ser  Pro Ala Lys 
    1865                 1870                 1875             


Lys Arg  Pro Ala Ala Ala Ala  Ala Ala Ser Ala Ser  Asp Ser Asp 
    1880                 1885                 1890             


Ser Leu  Gly Gly Asp Ala Pro  Ala Ala Ala Ala Cys  Ala Val Gly 
    1895                 1900                 1905             


Glu Gly  Asp Ser Pro Pro Ala  Pro Arg Glu Glu Glu  Pro Arg Arg 
    1910                 1915                 1920             


Phe Val  Thr Trp Asn Ala Asn  Ser Leu Leu Leu Arg  Met Lys Ser 
    1925                 1930                 1935             


Asp Trp  Pro Ala Phe Cys Gln  Phe Val Ser Arg Val  Asp Pro Asp 
    1940                 1945                 1950             


Val Ile  Cys Val Gln Glu Val  Arg Met Pro Ala Ala  Gly Ser Lys 
    1955                 1960                 1965             


Gly Ala  Pro Lys Asn Pro Gly  Gln Leu Lys Asp Asp  Thr Ser Ser 
    1970                 1975                 1980             


Ser Arg  Asp Glu Lys Gln Val  Val Leu Arg Ala Leu  Ser Ser Pro 
    1985                 1990                 1995             


Pro Phe  Lys Asp Tyr Arg Val  Trp Trp Ser Leu Ser  Asp Ser Lys 
    2000                 2005                 2010             


Tyr Ala  Gly Thr Ala Met Ile  Ile Lys Lys Lys Phe  Glu Pro Lys 
    2015                 2020                 2025             


Lys Val  Ser Phe Asn Leu Asp  Arg Thr Ser Ser Lys  His Glu Pro 
    2030                 2035                 2040             


Asp Gly  Arg Val Ile Ile Ala  Glu Phe Glu Ser Phe  Leu Leu Leu 
    2045                 2050                 2055             


Asn Thr  Tyr Ala Pro Asn Asn  Gly Trp Lys Glu Glu  Glu Asn Ser 
    2060                 2065                 2070             


Phe Gln  Arg Arg Arg Lys Trp  Asp Lys Arg Met Leu  Glu Phe Val 
    2075                 2080                 2085             


Gln Gln  Val Asp Lys Pro Leu  Ile Trp Cys Gly Ala  Leu Val Val 
    2090                 2095                 2100             


Ser His  Glu Glu Ile Asp Val  Ser His Pro Asp Phe  Phe Ser Ser 
    2105                 2110                 2115             


Ala Lys  Leu Asn Gly Tyr Ile  Pro Pro Asn Lys Glu  Asp Cys Gly 
    2120                 2125                 2130             


Gln Pro  Gly Phe Thr Leu Ser  Glu Arg Arg Arg Phe  Gly Asn Ile 
    2135                 2140                 2145             


Leu Ser  Gln Gly Lys Leu Val  Asp Ala Tyr Arg Tyr  Leu His Lys 
    2150                 2155                 2160             


Glu Lys  Asp Met Asp Cys Gly  Phe Ser Trp Ser Gly  His Pro Ile 
    2165                 2170                 2175             


Gly Lys  Tyr Arg Gly Lys Arg  Met Arg Ile Asp Tyr  Phe Leu Val 
    2180                 2185                 2190             


Ser Glu  Lys Leu Lys Asp Gln  Ile Val Ser Cys Asp  Ile His Gly 
    2195                 2200                 2205             


Arg Gly  Ile Glu Leu Glu Gly  Phe Tyr Gly Ser Asp  His Cys Pro 
    2210                 2215                 2220             


Val Ser  Leu Glu Leu Ser Glu  Glu Val Glu Ala Pro  Lys Pro Lys 
    2225                 2230                 2235             


Ser Ser  Asn Pro Lys Lys Lys  Arg Lys Val 
    2240                 2245             


<210>  15
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAPE01g (D297A)

<400>  15

Ser Ala Ile Arg Ala Ser Ser His Arg Leu Gln Thr Arg Thr Val Ala 
1               5                   10                  15      


Leu Thr Arg Thr Lys Met Ser Ser Met Ala Gly Leu Gly Ala Ser Gln 
            20                  25                  30          


His Gly Tyr Pro Pro Arg Ser His Glu Pro Trp Thr Lys Leu Val His 
        35                  40                  45              


Arg Glu Arg Leu Pro Glu Trp Phe Ala Tyr Asn Pro Lys Thr Met Arg 
    50                  55                  60                  


Pro Pro Pro Leu Ser His Asp Thr Lys Cys Met Lys Ile Leu Ser Trp 
65                  70                  75                  80  


Asn Ile Asn Gly Leu His Asp Val Val Thr Thr Lys Gly Phe Ser Ala 
                85                  90                  95      


Arg Asp Leu Ala Gln Arg Glu Asn Phe Asp Val Leu Cys Leu Gln Glu 
            100                 105                 110         


Thr His Leu Glu Glu Lys Asp Val Glu Lys Phe Lys Asn Leu Ile Ala 
        115                 120                 125             


Asp Tyr Asp Ser Tyr Trp Ser Cys Ser Val Ser Arg Leu Gly Tyr Ser 
    130                 135                 140                 


Gly Thr Ala Val Ile Ser Arg Val Lys Pro Ile Ser Val Gln Tyr Gly 
145                 150                 155                 160 


Ile Gly Ile Arg Glu His Asp His Glu Gly Arg Val Ile Thr Leu Glu 
                165                 170                 175     


Phe Asp Gly Phe Tyr Leu Val Asn Ala Tyr Val Pro Asn Ser Gly Arg 
            180                 185                 190         


Phe Leu Arg Arg Leu Asn Tyr Arg Val Asn Asn Trp Asp Pro Cys Phe 
        195                 200                 205             


Ser Asn Tyr Val Lys Ile Leu Glu Lys Ser Lys Pro Val Ile Val Ala 
    210                 215                 220                 


Gly Asp Leu Asn Cys Ala Arg Gln Ser Ile Asp Ile His Asn Pro Pro 
225                 230                 235                 240 


Ala Lys Thr Lys Ser Ala Gly Phe Thr Ile Glu Glu Arg Glu Ser Phe 
                245                 250                 255     


Glu Thr Asn Phe Ser Ser Lys Gly Leu Val Asp Thr Phe Arg Lys Gln 
            260                 265                 270         


His Pro Asn Ala Val Gly Tyr Thr Phe Trp Gly Glu Asn Gln Arg Ile 
        275                 280                 285             


Thr Asn Lys Gly Trp Arg Leu Ala Tyr Phe Leu Ala Ser Glu Ser Ile 
    290                 295                 300                 


Thr Asp Lys Val His Asp Ser Tyr Ile Leu Pro Asp Val Ser Phe Ser 
305                 310                 315                 320 


Asp His Ser Pro Ile Gly Leu Val Leu Lys Leu 
                325                 330     


<210>  16
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAPE12g (D327A)

<400>  16

Lys Arg Phe Phe Gln Pro Val Pro Lys Asp Gly Ser Pro Ala Lys Lys 
1               5                   10                  15      


Arg Pro Ala Ala Ala Ala Ala Ala Ser Ala Ser Asp Ser Asp Ser Leu 
            20                  25                  30          


Gly Gly Asp Ala Pro Ala Ala Ala Ala Cys Ala Val Gly Glu Gly Asp 
        35                  40                  45              


Ser Pro Pro Ala Pro Arg Glu Glu Glu Pro Arg Arg Phe Val Thr Trp 
    50                  55                  60                  


Asn Ala Asn Ser Leu Leu Leu Arg Met Lys Ser Asp Trp Pro Ala Phe 
65                  70                  75                  80  


Cys Gln Phe Val Ser Arg Val Asp Pro Asp Val Ile Cys Val Gln Glu 
                85                  90                  95      


Val Arg Met Pro Ala Ala Gly Ser Lys Gly Ala Pro Lys Asn Pro Gly 
            100                 105                 110         


Gln Leu Lys Asp Asp Thr Ser Ser Ser Arg Asp Glu Lys Gln Val Val 
        115                 120                 125             


Leu Arg Ala Leu Ser Ser Pro Pro Phe Lys Asp Tyr Arg Val Trp Trp 
    130                 135                 140                 


Ser Leu Ser Asp Ser Lys Tyr Ala Gly Thr Ala Met Ile Ile Lys Lys 
145                 150                 155                 160 


Lys Phe Glu Pro Lys Lys Val Ser Phe Asn Leu Asp Arg Thr Ser Ser 
                165                 170                 175     


Lys His Glu Pro Asp Gly Arg Val Ile Ile Ala Glu Phe Glu Ser Phe 
            180                 185                 190         


Leu Leu Leu Asn Thr Tyr Ala Pro Asn Asn Gly Trp Lys Glu Glu Glu 
        195                 200                 205             


Asn Ser Phe Gln Arg Arg Arg Lys Trp Asp Lys Arg Met Leu Glu Phe 
    210                 215                 220                 


Val Gln Gln Val Asp Lys Pro Leu Ile Trp Cys Gly Asp Leu Asn Val 
225                 230                 235                 240 


Ser His Glu Glu Ile Asp Val Ser His Pro Asp Phe Phe Ser Ser Ala 
                245                 250                 255     


Lys Leu Asn Gly Tyr Ile Pro Pro Asn Lys Glu Asp Cys Gly Gln Pro 
            260                 265                 270         


Gly Phe Thr Leu Ser Glu Arg Arg Arg Phe Gly Asn Ile Leu Ser Gln 
        275                 280                 285             


Gly Lys Leu Val Asp Ala Tyr Arg Tyr Leu His Lys Glu Lys Asp Met 
    290                 295                 300                 


Asp Cys Gly Phe Ser Trp Ser Gly His Pro Ile Gly Lys Tyr Arg Gly 
305                 310                 315                 320 


Lys Arg Met Arg Ile Ala Tyr Phe Leu Val Ser Glu Lys Leu Lys Asp 
                325                 330                 335     


Gln Ile Val Ser Cys Asp Ile His Gly Arg Gly Ile Glu Leu Glu Gly 
            340                 345                 350         


Phe Tyr Gly Ser Asp His Cys Pro Val Ser Leu Glu Leu Ser Glu Glu 
        355                 360                 365             


Val Glu Ala Pro Lys Pro Lys Ser Ser Asn 
    370                 375             


<210>  17
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hRad18

<400>  17

Asp Ser Leu Ala Glu Ser Arg Trp Pro Pro Gly Leu Ala Val Met Lys 
1               5                   10                  15      


Thr Ile Asp Asp Leu Leu Arg Cys Gly Ile Cys Phe Glu Tyr Phe Asn 
            20                  25                  30          


Ile Ala Met Ile Ile Pro Gln Cys Ser His Asn Tyr Cys Ser Leu Cys 
        35                  40                  45              


Ile Arg Lys Phe Leu Ser Tyr Lys Thr Gln Cys Pro Thr Cys Cys Val 
    50                  55                  60                  


Thr Val Thr Glu Pro Asp Leu Lys Asn Asn Arg Ile Leu Asp Glu Leu 
65                  70                  75                  80  


Val Lys Ser Leu Asn Phe Ala Arg Asn His Leu Leu Gln Phe Ala Leu 
                85                  90                  95      


Glu Ser Pro Ala Lys Ser Pro Ala Ser Ser Ser Ser Lys Asn Leu Ala 
            100                 105                 110         


Val Lys Val Tyr Thr Pro Val Ala Ser Arg Gln Ser Leu Lys Gln Gly 
        115                 120                 125             


Ser Arg Leu Met Asp Asn Phe Leu Ile Arg Glu Met Ser Gly Ser Thr 
    130                 135                 140                 


Ser Glu Leu Leu Ile Lys Glu Asn Lys Ser Lys Phe Ser Pro Gln Lys 
145                 150                 155                 160 


Glu Ala Ser Pro Ala Ala Lys Thr Lys Glu Thr Arg Ser Val Glu Glu 
                165                 170                 175     


Ile Ala Pro Asp Pro Ser Glu Ala Lys Arg Pro Glu Pro Pro Ser Thr 
            180                 185                 190         


Ser Thr Leu Lys Gln Val Thr Lys Val Asp Cys Pro Val Cys Gly Val 
        195                 200                 205             


Asn Ile Pro Glu Ser His Ile Asn Lys His Leu Asp Ser Cys Leu Ser 
    210                 215                 220                 


Arg Glu Glu Lys Lys Glu Ser Leu Arg Ser Ser Val His Lys Arg Lys 
225                 230                 235                 240 


Pro Leu Pro Lys Thr Val Tyr Asn Leu Leu Ser Asp Arg Asp Leu Lys 
                245                 250                 255     


Lys Lys Leu Lys Glu His Gly Leu Ser Ile Gln Gly Asn Lys Gln Gln 
            260                 265                 270         


Leu Ile Lys Arg His Gln Glu Phe Val His Met Tyr Asn Ala Gln Cys 
        275                 280                 285             


Asp Ala Leu His Pro Lys Ser Ala Ala Glu Ile Val Arg Glu Ile Glu 
    290                 295                 300                 


Asn Ile Glu Lys Thr Arg Met Arg Leu Glu Ala Ser Lys Leu Asn Glu 
305                 310                 315                 320 


Ser Val Met Val Phe Thr Lys Asp Gln Thr Glu Lys Glu Ile Asp Glu 
                325                 330                 335     


Ile His Ser Lys Tyr Arg Lys Lys His Lys Ser Glu Phe Gln Leu Leu 
            340                 345                 350         


Val Asp Gln Ala Arg Lys Gly Tyr Lys Lys Ile Ala Gly Met Ser Gln 
        355                 360                 365             


Lys Thr Val Thr Ile Thr Lys Glu Asp Glu Ser Thr Glu Lys Leu Ser 
    370                 375                 380                 


Ser Val Cys Met Gly Gln Glu Asp Asn Met Thr Ser Val Thr Asn His 
385                 390                 395                 400 


Phe Ser Gln Ser Lys Leu Asp Ser Pro Glu Glu Leu Glu Pro Asp Arg 
                405                 410                 415     


Glu Glu Asp Ser Ser Ser Cys Ile Asp Ile Gln Glu Val Leu Ser Ser 
            420                 425                 430         


Ser Glu Ser Asp Ser Cys Asn Ser Ser Ser Ser Asp Ile Ile Arg Asp 
        435                 440                 445             


Leu Leu Glu Glu Glu Glu Ala Trp Glu Ala Ser His Lys Asn Asp Leu 
    450                 455                 460                 


Gln Asp Thr Glu Ile Ser Pro Arg Gln Asn Arg Arg Thr Arg Ala Ala 
465                 470                 475                 480 


Glu Ser Ala Glu Ile Glu Pro Arg Asn Lys Arg Asn Arg Asn 
                485                 490                 


<210>  18
<211>  332
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APE01g

<400>  18

Met Ser Ala Ile Arg Ala Ser Ser His Arg Leu Gln Thr Arg Thr Val 
1               5                   10                  15      


Ala Leu Thr Arg Thr Lys Met Ser Ser Met Ala Gly Leu Gly Ala Ser 
            20                  25                  30          


Gln His Gly Tyr Pro Pro Arg Ser His Glu Pro Trp Thr Lys Leu Val 
        35                  40                  45              


His Arg Glu Arg Leu Pro Glu Trp Phe Ala Tyr Asn Pro Lys Thr Met 
    50                  55                  60                  


Arg Pro Pro Pro Leu Ser His Asp Thr Lys Cys Met Lys Ile Leu Ser 
65                  70                  75                  80  


Trp Asn Ile Asn Gly Leu His Asp Val Val Thr Thr Lys Gly Phe Ser 
                85                  90                  95      


Ala Arg Asp Leu Ala Gln Arg Glu Asn Phe Asp Val Leu Cys Leu Gln 
            100                 105                 110         


Glu Thr His Leu Glu Glu Lys Asp Val Glu Lys Phe Lys Asn Leu Ile 
        115                 120                 125             


Ala Asp Tyr Asp Ser Tyr Trp Ser Cys Ser Val Ser Arg Leu Gly Tyr 
    130                 135                 140                 


Ser Gly Thr Ala Val Ile Ser Arg Val Lys Pro Ile Ser Val Gln Tyr 
145                 150                 155                 160 


Gly Ile Gly Ile Arg Glu His Asp His Glu Gly Arg Val Ile Thr Leu 
                165                 170                 175     


Glu Phe Asp Gly Phe Tyr Leu Val Asn Ala Tyr Val Pro Asn Ser Gly 
            180                 185                 190         


Arg Phe Leu Arg Arg Leu Asn Tyr Arg Val Asn Asn Trp Asp Pro Cys 
        195                 200                 205             


Phe Ser Asn Tyr Val Lys Ile Leu Glu Lys Ser Lys Pro Val Ile Val 
    210                 215                 220                 


Ala Gly Asp Leu Asn Cys Ala Arg Gln Ser Ile Asp Ile His Asn Pro 
225                 230                 235                 240 


Pro Ala Lys Thr Lys Ser Ala Gly Phe Thr Ile Glu Glu Arg Glu Ser 
                245                 250                 255     


Phe Glu Thr Asn Phe Ser Ser Lys Gly Leu Val Asp Thr Phe Arg Lys 
            260                 265                 270         


Gln His Pro Asn Ala Val Gly Tyr Thr Phe Trp Gly Glu Asn Gln Arg 
        275                 280                 285             


Ile Thr Asn Lys Gly Trp Arg Leu Asp Tyr Phe Leu Ala Ser Glu Ser 
    290                 295                 300                 


Ile Thr Asp Lys Val His Asp Ser Tyr Ile Leu Pro Asp Val Ser Phe 
305                 310                 315                 320 


Ser Asp His Ser Pro Ile Gly Leu Val Leu Lys Leu 
                325                 330         


<210>  19
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APE12g

<400>  19

Met Lys Arg Phe Phe Gln Pro Val Pro Lys Asp Gly Ser Pro Ala Lys 
1               5                   10                  15      


Lys Arg Pro Ala Ala Ala Ala Ala Ala Ser Ala Ser Asp Ser Asp Ser 
            20                  25                  30          


Leu Gly Gly Asp Ala Pro Ala Ala Ala Ala Cys Ala Val Gly Glu Gly 
        35                  40                  45              


Asp Ser Pro Pro Ala Pro Arg Glu Glu Glu Pro Arg Arg Phe Val Thr 
    50                  55                  60                  


Trp Asn Ala Asn Ser Leu Leu Leu Arg Met Lys Ser Asp Trp Pro Ala 
65                  70                  75                  80  


Phe Cys Gln Phe Val Ser Arg Val Asp Pro Asp Val Ile Cys Val Gln 
                85                  90                  95      


Glu Val Arg Met Pro Ala Ala Gly Ser Lys Gly Ala Pro Lys Asn Pro 
            100                 105                 110         


Gly Gln Leu Lys Asp Asp Thr Ser Ser Ser Arg Asp Glu Lys Gln Val 
        115                 120                 125             


Val Leu Arg Ala Leu Ser Ser Pro Pro Phe Lys Asp Tyr Arg Val Trp 
    130                 135                 140                 


Trp Ser Leu Ser Asp Ser Lys Tyr Ala Gly Thr Ala Met Ile Ile Lys 
145                 150                 155                 160 


Lys Lys Phe Glu Pro Lys Lys Val Ser Phe Asn Leu Asp Arg Thr Ser 
                165                 170                 175     


Ser Lys His Glu Pro Asp Gly Arg Val Ile Ile Ala Glu Phe Glu Ser 
            180                 185                 190         


Phe Leu Leu Leu Asn Thr Tyr Ala Pro Asn Asn Gly Trp Lys Glu Glu 
        195                 200                 205             


Glu Asn Ser Phe Gln Arg Arg Arg Lys Trp Asp Lys Arg Met Leu Glu 
    210                 215                 220                 


Phe Val Gln Gln Val Asp Lys Pro Leu Ile Trp Cys Gly Asp Leu Asn 
225                 230                 235                 240 


Val Ser His Glu Glu Ile Asp Val Ser His Pro Asp Phe Phe Ser Ser 
                245                 250                 255     


Ala Lys Leu Asn Gly Tyr Ile Pro Pro Asn Lys Glu Asp Cys Gly Gln 
            260                 265                 270         


Pro Gly Phe Thr Leu Ser Glu Arg Arg Arg Phe Gly Asn Ile Leu Ser 
        275                 280                 285             


Gln Gly Lys Leu Val Asp Ala Tyr Arg Tyr Leu His Lys Glu Lys Asp 
    290                 295                 300                 


Met Asp Cys Gly Phe Ser Trp Ser Gly His Pro Ile Gly Lys Tyr Arg 
305                 310                 315                 320 


Gly Lys Arg Met Arg Ile Asp Tyr Phe Leu Val Ser Glu Lys Leu Lys 
                325                 330                 335     


Asp Gln Ile Val Ser Cys Asp Ile His Gly Arg Gly Ile Glu Leu Glu 
            340                 345                 350         


Gly Phe Tyr Gly Ser Asp His Cys Pro Val Ser Leu Glu Leu Ser Glu 
        355                 360                 365             


Glu Val Glu Ala Pro Lys Pro Lys Ser Ser Asn 
    370                 375                 


<210>  20
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OsPCNA (wt)

<400>  20

Met Leu Glu Leu Arg Leu Val Gln Gly Ser Leu Leu Lys Lys Val Leu 
1               5                   10                  15      


Glu Ala Ile Arg Glu Leu Val Thr Asp Ala Asn Phe Asp Cys Ser Gly 
            20                  25                  30          


Thr Gly Phe Ser Leu Gln Ala Met Asp Ser Ser His Val Ala Leu Val 
        35                  40                  45              


Ala Leu Leu Leu Arg Ser Glu Gly Phe Glu His Tyr Arg Cys Asp Arg 
    50                  55                  60                  


Asn Leu Ser Met Gly Met Asn Leu Asn Asn Met Ala Lys Met Leu Arg 
65                  70                  75                  80  


Cys Ala Gly Asn Asp Asp Ile Ile Thr Ile Lys Ala Asp Asp Gly Ser 
                85                  90                  95      


Asp Thr Val Thr Phe Met Phe Glu Ser Pro Asn Gln Asp Lys Ile Ala 
            100                 105                 110         


Asp Phe Glu Met Lys Leu Met Asp Ile Asp Ser Glu His Leu Gly Ile 
        115                 120                 125             


Pro Asp Ser Glu Tyr Gln Ala Ile Val Arg Met Pro Ser Ser Glu Phe 
    130                 135                 140                 


Ser Arg Ile Cys Lys Asp Leu Ser Ser Ile Gly Asp Thr Val Ile Ile 
145                 150                 155                 160 


Ser Val Thr Lys Glu Gly Val Lys Phe Ser Thr Ala Gly Asp Ile Gly 
                165                 170                 175     


Thr Ala Asn Ile Val Cys Arg Gln Asn Lys Thr Val Asp Lys Pro Glu 
            180                 185                 190         


Asp Ala Thr Ile Ile Glu Met Gln Glu Pro Val Ser Leu Thr Phe Ala 
        195                 200                 205             


Leu Arg Tyr Met Asn Ser Phe Thr Lys Ala Ser Pro Leu Ser Glu Gln 
    210                 215                 220                 


Val Thr Ile Ser Leu Ser Ser Glu Leu Pro Val Val Val Glu Tyr Lys 
225                 230                 235                 240 


Ile Ala Glu Met Gly Tyr Ile Arg Phe Tyr Leu Ala Pro Lys Ile Glu 
                245                 250                 255     


Glu Asp Glu Glu Met Lys Ser 
            260             


<210>  21
<211>  2204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PCGBE-3ϵͳʾںϵ

<400>  21

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn Ser Gly Ser Glu Thr Pro Gly Thr Ser 
        195                 200                 205             


Glu Ser Ala Thr Pro Glu Ser Arg Pro Asp Lys Lys Tyr Ser Ile Gly 
    210                 215                 220                 


Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
225                 230                 235                 240 


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
                245                 250                 255     


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
            260                 265                 270         


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
        275                 280                 285             


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
    290                 295                 300                 


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
305                 310                 315                 320 


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
                325                 330                 335     


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
            340                 345                 350         


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
        355                 360                 365             


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
    370                 375                 380                 


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
385                 390                 395                 400 


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
                405                 410                 415     


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
            420                 425                 430         


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
        435                 440                 445             


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
    450                 455                 460                 


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
465                 470                 475                 480 


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
                485                 490                 495     


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
            500                 505                 510         


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
        515                 520                 525             


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
    530                 535                 540                 


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
545                 550                 555                 560 


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
                565                 570                 575     


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
            580                 585                 590         


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
        595                 600                 605             


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
    610                 615                 620                 


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
625                 630                 635                 640 


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
                645                 650                 655     


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
            660                 665                 670         


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
        675                 680                 685             


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
    690                 695                 700                 


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
705                 710                 715                 720 


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
                725                 730                 735     


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
            740                 745                 750         


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
        755                 760                 765             


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
    770                 775                 780                 


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
785                 790                 795                 800 


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
                805                 810                 815     


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
            820                 825                 830         


Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile 
        835                 840                 845             


Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met 
    850                 855                 860                 


Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg 
865                 870                 875                 880 


Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu 
                885                 890                 895     


Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu 
            900                 905                 910         


Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln 
        915                 920                 925             


Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala 
    930                 935                 940                 


Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val 
945                 950                 955                 960 


Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val 
                965                 970                 975     


Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn 
            980                 985                 990         


Ser Arg Glu Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
        995                 1000                 1005             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1010                 1015                 1020             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1025                 1030                 1035             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1040                 1045                 1050             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1055                 1060                 1065             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1070                 1075                 1080             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1085                 1090                 1095             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1100                 1105                 1110             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1115                 1120                 1125             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1130                 1135                 1140             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1145                 1150                 1155             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1160                 1165                 1170             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1175                 1180                 1185             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1190                 1195                 1200             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1205                 1210                 1215             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1220                 1225                 1230             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1235                 1240                 1245             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1250                 1255                 1260             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1265                 1270                 1275             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1280                 1285                 1290             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1295                 1300                 1305             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1310                 1315                 1320             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1325                 1330                 1335             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1340                 1345                 1350             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1355                 1360                 1365             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1370                 1375                 1380             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1385                 1390                 1395             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1400                 1405                 1410             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1415                 1420                 1425             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1430                 1435                 1440             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1445                 1450                 1455             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1460                 1465                 1470             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1475                 1480                 1485             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1490                 1495                 1500             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1505                 1510                 1515             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1520                 1525                 1530             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1535                 1540                 1545             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1550                 1555                 1560             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1565                 1570                 1575             


Ser Gln  Leu Gly Gly Asp Lys  Arg Pro Ala Ala Thr  Lys Lys Ala 
    1580                 1585                 1590             


Gly Gln  Ala Lys Lys Lys Lys  Gly Thr Asp Ser Gly  Gly Ser Ala 
    1595                 1600                 1605             


Asn Glu  Leu Thr Trp His Asp  Val Leu Ala Glu Glu  Lys Gln Gln 
    1610                 1615                 1620             


Pro Tyr  Phe Leu Asn Thr Leu  Gln Thr Val Ala Ser  Glu Arg Gln 
    1625                 1630                 1635             


Ser Gly  Val Thr Ile Tyr Pro  Pro Gln Lys Asp Val  Phe Asn Ala 
    1640                 1645                 1650             


Phe Arg  Phe Thr Glu Leu Gly  Asp Val Lys Val Val  Ile Leu Gly 
    1655                 1660                 1665             


Gln Asp  Pro Tyr His Gly Pro  Gly Gln Ala His Gly  Leu Ala Phe 
    1670                 1675                 1680             


Ser Val  Arg Pro Gly Ile Ala  Ile Pro Pro Ser Leu  Leu Asn Met 
    1685                 1690                 1695             


Tyr Lys  Glu Leu Glu Asn Thr  Ile Pro Gly Phe Thr  Arg Pro Asn 
    1700                 1705                 1710             


His Gly  Tyr Leu Glu Ser Trp  Ala Arg Gln Gly Val  Leu Leu Leu 
    1715                 1720                 1725             


Asn Thr  Val Leu Thr Val Arg  Ala Gly Gln Ala His  Ser His Ala 
    1730                 1735                 1740             


Ser Leu  Gly Trp Glu Thr Phe  Thr Asp Lys Val Ile  Ser Leu Ile 
    1745                 1750                 1755             


Asn Gln  His Arg Glu Gly Val  Val Phe Leu Leu Trp  Gly Ser His 
    1760                 1765                 1770             


Ala Gln  Lys Lys Gly Ala Ile  Ile Asp Lys Gln Arg  His His Val 
    1775                 1780                 1785             


Leu Lys  Ala Pro His Pro Ser  Pro Leu Ser Ala His  Arg Gly Phe 
    1790                 1795                 1800             


Phe Gly  Cys Asn His Phe Val  Leu Ala Asn Gln Trp  Leu Glu Gln 
    1805                 1810                 1815             


Arg Gly  Glu Thr Pro Ile Asp  Trp Met Pro Val Leu  Pro Ala Glu 
    1820                 1825                 1830             


Ser Glu  Pro Lys Lys Lys Arg  Lys Val Leu Lys Glu  Gly Arg Gly 
    1835                 1840                 1845             


Ser Leu  Leu Thr Cys Gly Asp  Val Glu Glu Asn Pro  Gly Pro Ser 
    1850                 1855                 1860             


Ala Ile  Arg Ala Ser Ser His  Arg Leu Gln Thr Arg  Thr Val Ala 
    1865                 1870                 1875             


Leu Thr  Arg Thr Lys Met Ser  Ser Met Ala Gly Leu  Gly Ala Ser 
    1880                 1885                 1890             


Gln His  Gly Tyr Pro Pro Arg  Ser His Glu Pro Trp  Thr Lys Leu 
    1895                 1900                 1905             


Val His  Arg Glu Arg Leu Pro  Glu Trp Phe Ala Tyr  Asn Pro Lys 
    1910                 1915                 1920             


Thr Met  Arg Pro Pro Pro Leu  Ser His Asp Thr Lys  Cys Met Lys 
    1925                 1930                 1935             


Ile Leu  Ser Trp Asn Ile Asn  Gly Leu His Asp Val  Val Thr Thr 
    1940                 1945                 1950             


Lys Gly  Phe Ser Ala Arg Asp  Leu Ala Gln Arg Glu  Asn Phe Asp 
    1955                 1960                 1965             


Val Leu  Cys Leu Gln Glu Thr  His Leu Glu Glu Lys  Asp Val Glu 
    1970                 1975                 1980             


Lys Phe  Lys Asn Leu Ile Ala  Asp Tyr Asp Ser Tyr  Trp Ser Cys 
    1985                 1990                 1995             


Ser Val  Ser Arg Leu Gly Tyr  Ser Gly Thr Ala Val  Ile Ser Arg 
    2000                 2005                 2010             


Val Lys  Pro Ile Ser Val Gln  Tyr Gly Ile Gly Ile  Arg Glu His 
    2015                 2020                 2025             


Asp His  Glu Gly Arg Val Ile  Thr Leu Glu Phe Asp  Gly Phe Tyr 
    2030                 2035                 2040             


Leu Val  Asn Ala Tyr Val Pro  Asn Ser Gly Arg Phe  Leu Arg Arg 
    2045                 2050                 2055             


Leu Asn  Tyr Arg Val Asn Asn  Trp Asp Pro Cys Phe  Ser Asn Tyr 
    2060                 2065                 2070             


Val Lys  Ile Leu Glu Lys Ser  Lys Pro Val Ile Val  Ala Gly Asp 
    2075                 2080                 2085             


Leu Asn  Cys Ala Arg Gln Ser  Ile Asp Ile His Asn  Pro Pro Ala 
    2090                 2095                 2100             


Lys Thr  Lys Ser Ala Gly Phe  Thr Ile Glu Glu Arg  Glu Ser Phe 
    2105                 2110                 2115             


Glu Thr  Asn Phe Ser Ser Lys  Gly Leu Val Asp Thr  Phe Arg Lys 
    2120                 2125                 2130             


Gln His  Pro Asn Ala Val Gly  Tyr Thr Phe Trp Gly  Glu Asn Gln 
    2135                 2140                 2145             


Arg Ile  Thr Asn Lys Gly Trp  Arg Leu Ala Tyr Phe  Leu Ala Ser 
    2150                 2155                 2160             


Glu Ser  Ile Thr Asp Lys Val  His Asp Ser Tyr Ile  Leu Pro Asp 
    2165                 2170                 2175             


Val Ser  Phe Ser Asp His Ser  Pro Ile Gly Leu Val  Leu Lys Leu 
    2180                 2185                 2190             


Ser Gly  Gly Ser Pro Lys Lys  Lys Arg Lys Val 
    2195                 2200                 


<210>  22
<211>  2251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PCGBE-4ϵͳʾںϵ

<400>  22

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn Ser Gly Ser Glu Thr Pro Gly Thr Ser 
        195                 200                 205             


Glu Ser Ala Thr Pro Glu Ser Arg Pro Asp Lys Lys Tyr Ser Ile Gly 
    210                 215                 220                 


Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
225                 230                 235                 240 


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
                245                 250                 255     


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
            260                 265                 270         


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
        275                 280                 285             


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
    290                 295                 300                 


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
305                 310                 315                 320 


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
                325                 330                 335     


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
            340                 345                 350         


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
        355                 360                 365             


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
    370                 375                 380                 


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
385                 390                 395                 400 


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
                405                 410                 415     


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
            420                 425                 430         


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
        435                 440                 445             


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
    450                 455                 460                 


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
465                 470                 475                 480 


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
                485                 490                 495     


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
            500                 505                 510         


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
        515                 520                 525             


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
    530                 535                 540                 


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
545                 550                 555                 560 


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
                565                 570                 575     


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
            580                 585                 590         


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
        595                 600                 605             


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
    610                 615                 620                 


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
625                 630                 635                 640 


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
                645                 650                 655     


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
            660                 665                 670         


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
        675                 680                 685             


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
    690                 695                 700                 


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
705                 710                 715                 720 


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
                725                 730                 735     


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
            740                 745                 750         


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
        755                 760                 765             


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
    770                 775                 780                 


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
785                 790                 795                 800 


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
                805                 810                 815     


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
            820                 825                 830         


Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile 
        835                 840                 845             


Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met 
    850                 855                 860                 


Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg 
865                 870                 875                 880 


Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu 
                885                 890                 895     


Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu 
            900                 905                 910         


Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln 
        915                 920                 925             


Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala 
    930                 935                 940                 


Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val 
945                 950                 955                 960 


Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val 
                965                 970                 975     


Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn 
            980                 985                 990         


Ser Arg Glu Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
        995                 1000                 1005             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1010                 1015                 1020             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1025                 1030                 1035             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1040                 1045                 1050             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1055                 1060                 1065             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1070                 1075                 1080             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1085                 1090                 1095             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1100                 1105                 1110             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1115                 1120                 1125             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1130                 1135                 1140             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1145                 1150                 1155             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1160                 1165                 1170             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1175                 1180                 1185             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1190                 1195                 1200             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1205                 1210                 1215             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1220                 1225                 1230             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1235                 1240                 1245             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1250                 1255                 1260             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1265                 1270                 1275             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1280                 1285                 1290             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1295                 1300                 1305             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1310                 1315                 1320             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1325                 1330                 1335             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1340                 1345                 1350             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1355                 1360                 1365             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1370                 1375                 1380             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1385                 1390                 1395             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1400                 1405                 1410             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1415                 1420                 1425             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1430                 1435                 1440             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1445                 1450                 1455             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1460                 1465                 1470             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1475                 1480                 1485             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1490                 1495                 1500             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1505                 1510                 1515             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1520                 1525                 1530             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1535                 1540                 1545             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1550                 1555                 1560             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1565                 1570                 1575             


Ser Gln  Leu Gly Gly Asp Lys  Arg Pro Ala Ala Thr  Lys Lys Ala 
    1580                 1585                 1590             


Gly Gln  Ala Lys Lys Lys Lys  Gly Thr Asp Ser Gly  Gly Ser Ala 
    1595                 1600                 1605             


Asn Glu  Leu Thr Trp His Asp  Val Leu Ala Glu Glu  Lys Gln Gln 
    1610                 1615                 1620             


Pro Tyr  Phe Leu Asn Thr Leu  Gln Thr Val Ala Ser  Glu Arg Gln 
    1625                 1630                 1635             


Ser Gly  Val Thr Ile Tyr Pro  Pro Gln Lys Asp Val  Phe Asn Ala 
    1640                 1645                 1650             


Phe Arg  Phe Thr Glu Leu Gly  Asp Val Lys Val Val  Ile Leu Gly 
    1655                 1660                 1665             


Gln Asp  Pro Tyr His Gly Pro  Gly Gln Ala His Gly  Leu Ala Phe 
    1670                 1675                 1680             


Ser Val  Arg Pro Gly Ile Ala  Ile Pro Pro Ser Leu  Leu Asn Met 
    1685                 1690                 1695             


Tyr Lys  Glu Leu Glu Asn Thr  Ile Pro Gly Phe Thr  Arg Pro Asn 
    1700                 1705                 1710             


His Gly  Tyr Leu Glu Ser Trp  Ala Arg Gln Gly Val  Leu Leu Leu 
    1715                 1720                 1725             


Asn Thr  Val Leu Thr Val Arg  Ala Gly Gln Ala His  Ser His Ala 
    1730                 1735                 1740             


Ser Leu  Gly Trp Glu Thr Phe  Thr Asp Lys Val Ile  Ser Leu Ile 
    1745                 1750                 1755             


Asn Gln  His Arg Glu Gly Val  Val Phe Leu Leu Trp  Gly Ser His 
    1760                 1765                 1770             


Ala Gln  Lys Lys Gly Ala Ile  Ile Asp Lys Gln Arg  His His Val 
    1775                 1780                 1785             


Leu Lys  Ala Pro His Pro Ser  Pro Leu Ser Ala His  Arg Gly Phe 
    1790                 1795                 1800             


Phe Gly  Cys Asn His Phe Val  Leu Ala Asn Gln Trp  Leu Glu Gln 
    1805                 1810                 1815             


Arg Gly  Glu Thr Pro Ile Asp  Trp Met Pro Val Leu  Pro Ala Glu 
    1820                 1825                 1830             


Ser Glu  Pro Lys Lys Lys Arg  Lys Val Leu Lys Glu  Gly Arg Gly 
    1835                 1840                 1845             


Ser Leu  Leu Thr Cys Gly Asp  Val Glu Glu Asn Pro  Gly Pro Lys 
    1850                 1855                 1860             


Arg Phe  Phe Gln Pro Val Pro  Lys Asp Gly Ser Pro  Ala Lys Lys 
    1865                 1870                 1875             


Arg Pro  Ala Ala Ala Ala Ala  Ala Ser Ala Ser Asp  Ser Asp Ser 
    1880                 1885                 1890             


Leu Gly  Gly Asp Ala Pro Ala  Ala Ala Ala Cys Ala  Val Gly Glu 
    1895                 1900                 1905             


Gly Asp  Ser Pro Pro Ala Pro  Arg Glu Glu Glu Pro  Arg Arg Phe 
    1910                 1915                 1920             


Val Thr  Trp Asn Ala Asn Ser  Leu Leu Leu Arg Met  Lys Ser Asp 
    1925                 1930                 1935             


Trp Pro  Ala Phe Cys Gln Phe  Val Ser Arg Val Asp  Pro Asp Val 
    1940                 1945                 1950             


Ile Cys  Val Gln Glu Val Arg  Met Pro Ala Ala Gly  Ser Lys Gly 
    1955                 1960                 1965             


Ala Pro  Lys Asn Pro Gly Gln  Leu Lys Asp Asp Thr  Ser Ser Ser 
    1970                 1975                 1980             


Arg Asp  Glu Lys Gln Val Val  Leu Arg Ala Leu Ser  Ser Pro Pro 
    1985                 1990                 1995             


Phe Lys  Asp Tyr Arg Val Trp  Trp Ser Leu Ser Asp  Ser Lys Tyr 
    2000                 2005                 2010             


Ala Gly  Thr Ala Met Ile Ile  Lys Lys Lys Phe Glu  Pro Lys Lys 
    2015                 2020                 2025             


Val Ser  Phe Asn Leu Asp Arg  Thr Ser Ser Lys His  Glu Pro Asp 
    2030                 2035                 2040             


Gly Arg  Val Ile Ile Ala Glu  Phe Glu Ser Phe Leu  Leu Leu Asn 
    2045                 2050                 2055             


Thr Tyr  Ala Pro Asn Asn Gly  Trp Lys Glu Glu Glu  Asn Ser Phe 
    2060                 2065                 2070             


Gln Arg  Arg Arg Lys Trp Asp  Lys Arg Met Leu Glu  Phe Val Gln 
    2075                 2080                 2085             


Gln Val  Asp Lys Pro Leu Ile  Trp Cys Gly Asp Leu  Asn Val Ser 
    2090                 2095                 2100             


His Glu  Glu Ile Asp Val Ser  His Pro Asp Phe Phe  Ser Ser Ala 
    2105                 2110                 2115             


Lys Leu  Asn Gly Tyr Ile Pro  Pro Asn Lys Glu Asp  Cys Gly Gln 
    2120                 2125                 2130             


Pro Gly  Phe Thr Leu Ser Glu  Arg Arg Arg Phe Gly  Asn Ile Leu 
    2135                 2140                 2145             


Ser Gln  Gly Lys Leu Val Asp  Ala Tyr Arg Tyr Leu  His Lys Glu 
    2150                 2155                 2160             


Lys Asp  Met Asp Cys Gly Phe  Ser Trp Ser Gly His  Pro Ile Gly 
    2165                 2170                 2175             


Lys Tyr  Arg Gly Lys Arg Met  Arg Ile Ala Tyr Phe  Leu Val Ser 
    2180                 2185                 2190             


Glu Lys  Leu Lys Asp Gln Ile  Val Ser Cys Asp Ile  His Gly Arg 
    2195                 2200                 2205             


Gly Ile  Glu Leu Glu Gly Phe  Tyr Gly Ser Asp His  Cys Pro Val 
    2210                 2215                 2220             


Ser Leu  Glu Leu Ser Glu Glu  Val Glu Ala Pro Lys  Pro Lys Ser 
    2225                 2230                 2235             


Ser Asn  Ser Gly Gly Ser Pro  Lys Lys Lys Arg Lys  Val 
    2240                 2245                 2250     


<210>  23
<211>  2367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PCGBE-5ϵͳʾںϵ

<400>  23

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn Ser Gly Ser Glu Thr Pro Gly Thr Ser 
        195                 200                 205             


Glu Ser Ala Thr Pro Glu Ser Arg Pro Asp Lys Lys Tyr Ser Ile Gly 
    210                 215                 220                 


Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
225                 230                 235                 240 


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
                245                 250                 255     


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
            260                 265                 270         


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
        275                 280                 285             


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
    290                 295                 300                 


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
305                 310                 315                 320 


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
                325                 330                 335     


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
            340                 345                 350         


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
        355                 360                 365             


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
    370                 375                 380                 


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
385                 390                 395                 400 


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
                405                 410                 415     


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
            420                 425                 430         


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
        435                 440                 445             


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
    450                 455                 460                 


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
465                 470                 475                 480 


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
                485                 490                 495     


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
            500                 505                 510         


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
        515                 520                 525             


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
    530                 535                 540                 


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
545                 550                 555                 560 


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
                565                 570                 575     


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
            580                 585                 590         


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
        595                 600                 605             


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
    610                 615                 620                 


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
625                 630                 635                 640 


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
                645                 650                 655     


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
            660                 665                 670         


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
        675                 680                 685             


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
    690                 695                 700                 


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
705                 710                 715                 720 


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
                725                 730                 735     


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
            740                 745                 750         


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
        755                 760                 765             


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
    770                 775                 780                 


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
785                 790                 795                 800 


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
                805                 810                 815     


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
            820                 825                 830         


Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile 
        835                 840                 845             


Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met 
    850                 855                 860                 


Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg 
865                 870                 875                 880 


Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu 
                885                 890                 895     


Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu 
            900                 905                 910         


Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln 
        915                 920                 925             


Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala 
    930                 935                 940                 


Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val 
945                 950                 955                 960 


Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val 
                965                 970                 975     


Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn 
            980                 985                 990         


Ser Arg Glu Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
        995                 1000                 1005             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1010                 1015                 1020             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1025                 1030                 1035             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1040                 1045                 1050             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1055                 1060                 1065             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1070                 1075                 1080             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1085                 1090                 1095             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1100                 1105                 1110             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1115                 1120                 1125             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1130                 1135                 1140             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1145                 1150                 1155             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1160                 1165                 1170             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1175                 1180                 1185             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1190                 1195                 1200             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1205                 1210                 1215             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1220                 1225                 1230             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1235                 1240                 1245             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1250                 1255                 1260             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1265                 1270                 1275             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1280                 1285                 1290             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1295                 1300                 1305             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1310                 1315                 1320             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1325                 1330                 1335             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1340                 1345                 1350             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1355                 1360                 1365             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr 
    1370                 1375                 1380             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu 
    1385                 1390                 1395             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1400                 1405                 1410             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1415                 1420                 1425             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1430                 1435                 1440             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1445                 1450                 1455             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1460                 1465                 1470             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1475                 1480                 1485             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1490                 1495                 1500             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1505                 1510                 1515             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1520                 1525                 1530             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1535                 1540                 1545             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1550                 1555                 1560             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1565                 1570                 1575             


Ser Gln  Leu Gly Gly Asp Lys  Arg Pro Ala Ala Thr  Lys Lys Ala 
    1580                 1585                 1590             


Gly Gln  Ala Lys Lys Lys Lys  Gly Thr Asp Ser Gly  Gly Ser Ala 
    1595                 1600                 1605             


Asn Glu  Leu Thr Trp His Asp  Val Leu Ala Glu Glu  Lys Gln Gln 
    1610                 1615                 1620             


Pro Tyr  Phe Leu Asn Thr Leu  Gln Thr Val Ala Ser  Glu Arg Gln 
    1625                 1630                 1635             


Ser Gly  Val Thr Ile Tyr Pro  Pro Gln Lys Asp Val  Phe Asn Ala 
    1640                 1645                 1650             


Phe Arg  Phe Thr Glu Leu Gly  Asp Val Lys Val Val  Ile Leu Gly 
    1655                 1660                 1665             


Gln Asp  Pro Tyr His Gly Pro  Gly Gln Ala His Gly  Leu Ala Phe 
    1670                 1675                 1680             


Ser Val  Arg Pro Gly Ile Ala  Ile Pro Pro Ser Leu  Leu Asn Met 
    1685                 1690                 1695             


Tyr Lys  Glu Leu Glu Asn Thr  Ile Pro Gly Phe Thr  Arg Pro Asn 
    1700                 1705                 1710             


His Gly  Tyr Leu Glu Ser Trp  Ala Arg Gln Gly Val  Leu Leu Leu 
    1715                 1720                 1725             


Asn Thr  Val Leu Thr Val Arg  Ala Gly Gln Ala His  Ser His Ala 
    1730                 1735                 1740             


Ser Leu  Gly Trp Glu Thr Phe  Thr Asp Lys Val Ile  Ser Leu Ile 
    1745                 1750                 1755             


Asn Gln  His Arg Glu Gly Val  Val Phe Leu Leu Trp  Gly Ser His 
    1760                 1765                 1770             


Ala Gln  Lys Lys Gly Ala Ile  Ile Asp Lys Gln Arg  His His Val 
    1775                 1780                 1785             


Leu Lys  Ala Pro His Pro Ser  Pro Leu Ser Ala His  Arg Gly Phe 
    1790                 1795                 1800             


Phe Gly  Cys Asn His Phe Val  Leu Ala Asn Gln Trp  Leu Glu Gln 
    1805                 1810                 1815             


Arg Gly  Glu Thr Pro Ile Asp  Trp Met Pro Val Leu  Pro Ala Glu 
    1820                 1825                 1830             


Ser Glu  Pro Lys Lys Lys Arg  Lys Val Leu Lys Glu  Gly Arg Gly 
    1835                 1840                 1845             


Ser Leu  Leu Thr Cys Gly Asp  Val Glu Glu Asn Pro  Gly Pro Asp 
    1850                 1855                 1860             


Ser Leu  Ala Glu Ser Arg Trp  Pro Pro Gly Leu Ala  Val Met Lys 
    1865                 1870                 1875             


Thr Ile  Asp Asp Leu Leu Arg  Cys Gly Ile Cys Phe  Glu Tyr Phe 
    1880                 1885                 1890             


Asn Ile  Ala Met Ile Ile Pro  Gln Cys Ser His Asn  Tyr Cys Ser 
    1895                 1900                 1905             


Leu Cys  Ile Arg Lys Phe Leu  Ser Tyr Lys Thr Gln  Cys Pro Thr 
    1910                 1915                 1920             


Cys Cys  Val Thr Val Thr Glu  Pro Asp Leu Lys Asn  Asn Arg Ile 
    1925                 1930                 1935             


Leu Asp  Glu Leu Val Lys Ser  Leu Asn Phe Ala Arg  Asn His Leu 
    1940                 1945                 1950             


Leu Gln  Phe Ala Leu Glu Ser  Pro Ala Lys Ser Pro  Ala Ser Ser 
    1955                 1960                 1965             


Ser Ser  Lys Asn Leu Ala Val  Lys Val Tyr Thr Pro  Val Ala Ser 
    1970                 1975                 1980             


Arg Gln  Ser Leu Lys Gln Gly  Ser Arg Leu Met Asp  Asn Phe Leu 
    1985                 1990                 1995             


Ile Arg  Glu Met Ser Gly Ser  Thr Ser Glu Leu Leu  Ile Lys Glu 
    2000                 2005                 2010             


Asn Lys  Ser Lys Phe Ser Pro  Gln Lys Glu Ala Ser  Pro Ala Ala 
    2015                 2020                 2025             


Lys Thr  Lys Glu Thr Arg Ser  Val Glu Glu Ile Ala  Pro Asp Pro 
    2030                 2035                 2040             


Ser Glu  Ala Lys Arg Pro Glu  Pro Pro Ser Thr Ser  Thr Leu Lys 
    2045                 2050                 2055             


Gln Val  Thr Lys Val Asp Cys  Pro Val Cys Gly Val  Asn Ile Pro 
    2060                 2065                 2070             


Glu Ser  His Ile Asn Lys His  Leu Asp Ser Cys Leu  Ser Arg Glu 
    2075                 2080                 2085             


Glu Lys  Lys Glu Ser Leu Arg  Ser Ser Val His Lys  Arg Lys Pro 
    2090                 2095                 2100             


Leu Pro  Lys Thr Val Tyr Asn  Leu Leu Ser Asp Arg  Asp Leu Lys 
    2105                 2110                 2115             


Lys Lys  Leu Lys Glu His Gly  Leu Ser Ile Gln Gly  Asn Lys Gln 
    2120                 2125                 2130             


Gln Leu  Ile Lys Arg His Gln  Glu Phe Val His Met  Tyr Asn Ala 
    2135                 2140                 2145             


Gln Cys  Asp Ala Leu His Pro  Lys Ser Ala Ala Glu  Ile Val Arg 
    2150                 2155                 2160             


Glu Ile  Glu Asn Ile Glu Lys  Thr Arg Met Arg Leu  Glu Ala Ser 
    2165                 2170                 2175             


Lys Leu  Asn Glu Ser Val Met  Val Phe Thr Lys Asp  Gln Thr Glu 
    2180                 2185                 2190             


Lys Glu  Ile Asp Glu Ile His  Ser Lys Tyr Arg Lys  Lys His Lys 
    2195                 2200                 2205             


Ser Glu  Phe Gln Leu Leu Val  Asp Gln Ala Arg Lys  Gly Tyr Lys 
    2210                 2215                 2220             


Lys Ile  Ala Gly Met Ser Gln  Lys Thr Val Thr Ile  Thr Lys Glu 
    2225                 2230                 2235             


Asp Glu  Ser Thr Glu Lys Leu  Ser Ser Val Cys Met  Gly Gln Glu 
    2240                 2245                 2250             


Asp Asn  Met Thr Ser Val Thr  Asn His Phe Ser Gln  Ser Lys Leu 
    2255                 2260                 2265             


Asp Ser  Pro Glu Glu Leu Glu  Pro Asp Arg Glu Glu  Asp Ser Ser 
    2270                 2275                 2280             


Ser Cys  Ile Asp Ile Gln Glu  Val Leu Ser Ser Ser  Glu Ser Asp 
    2285                 2290                 2295             


Ser Cys  Asn Ser Ser Ser Ser  Asp Ile Ile Arg Asp  Leu Leu Glu 
    2300                 2305                 2310             


Glu Glu  Glu Ala Trp Glu Ala  Ser His Lys Asn Asp  Leu Gln Asp 
    2315                 2320                 2325             


Thr Glu  Ile Ser Pro Arg Gln  Asn Arg Arg Thr Arg  Ala Ala Glu 
    2330                 2335                 2340             


Ser Ala  Glu Ile Glu Pro Arg  Asn Lys Arg Asn Arg  Asn Ser Gly 
    2345                 2350                 2355             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    2360                 2365         


