                               SEQUENCE LISTING

<110> HUIGENE THERAPEUTICS CO., LTD.
 
<120> ENGINEERED CRISPR/CAS13 SYSTEM AND USES THEREOF

<130> 132045-00819

<140> 
<141>

<160> 90    

<170> PatentIn version 3.5

<210> 1
<211> 2325
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1
atggcccagg tgagcaagca gacctccaag aagagggagc tgagcatcga cgagtaccag       60

ggcgcccgga agtggtgctt caccattgcc ttcaacaagg ccctggtgaa ccgggacaag      120

aacgacggcc tgttcgtgga aagcctgctg agacacgaga agtacagcaa gcacgactgg      180

tacgacgaag atacccgggc cctgatcaag tgcagcaccc aggccgccaa cgccaaggct      240

gaagccctgc ggaactactt cagtcactac cggcatagcc ctggctgcct gaccttcacc      300

gccgaggacg aactgcggac catcatggag agagcctatg agcgggccat cttcgagtgc      360

agaagaagag agacagaggt gatcatcgag tttcccagcc tgttcgaggg cgaccggatc      420

accaccgccg gcgtggtgtt tttcgtgagc tttttcgtgg aaagaagagt gctggatcgg      480

ctgtatggag ccgtgtccgg cctgaagaag aatgagggac agtacaagct gacccggaag      540

gccctgagca tgtactgcct gaaggacagc agattcacca aggcctggga taagcgggtg      600

ctgctgttca gagacatcct ggcccagctg ggaagaatcc ccgccgaggc ctacgagtac      660

taccacggcg agcagggtga taagaagaga gctaacgaca atgagggcac aaatcccaag      720

cggcacaagg acaagttcat cgaatttgca ctgcactacc tggaagccca gcacagcgag      780

atctgcttcg gcagacgcca catcgtgcgg gaagaggccg gcgccggcga tgagcacaag      840

aagcaccgga ccaagggaaa ggtggtggtg gacttcagca agaaggacga ggaccagagc      900

tactatatct ccaagaacaa cgtgatcgtg cggatcgaca agaacgccgg ccctagaagc      960

taccggatgg gcctgaacga gctgaagtac ctcgtgctgc tgagcctgca ggggaagggc     1020

gacgatgcca tcgccaagct gtacagatac agacagcacg tggagaacat cctggatgtg     1080

gtgaaggtga ccgataagga taaccacgtg ttcctgcccc gcttcgtgct ggagcagcac     1140

ggcatcggca gaaaggcctt caagcagcgg atcgatggac gggtgaagca cgtgcggggc     1200

gtgtgggaga agaagaaggc cgccaccaat gaaatgaccc tgcacgagaa ggccagagac     1260

atcctgcagt acgtgaacga aaactgcacc cggtccttca accctggcga atacaacaga     1320

ctgctggtgt gcctggtggg caaggacgtg gagaactttc aggccggcct gaagcggctg     1380

cagctggccg aaaggatcga tggccgggtg tactccatct tcgcccagac cagcaccatc     1440

aatgagatgc accaggtggt gtgcgaccag atcctgaacc ggctgtgcag aatcggcgac     1500

cagaagctgt acgattacgt gggactgggc aagaaggacg aaatcgacta caagcagaag     1560

gtggcctggt tcaaggagca catcagcatc cggagaggat tcctgagaaa gaagttctgg     1620

tacgatagca agaagggatt cgcaaagctg gtggaggaac acctggagtc cggcggcggc     1680

cagcgcgacg tgggcctgga caagaagtac taccacatcg acgccatcgg cagattcgag     1740

ggcgccaacc ccgccctgta cgagaccctg gccagagatc ggctgtgcct catgatggcc     1800

cagtacttcc tgggcagcgt gagaaaggaa ctgggcaaca agattgtgtg gagcaacgac     1860

agcatcgaac tgcctgtgga aggctctgtg ggaaatgaga agagcatcgt gttctccgtg     1920

tctgactacg gcaagctgta cgtgctggac gatgccgaat tcctgggccg gatctgcgaa     1980

tacttcatgc cccacgaaaa gggcaagatc cggtaccaca cagtgtacga aaagggcttt     2040

agagcataca acgacctgca gaagaagtgc gtggaggccg tgctggcttt cgaagagaag     2100

gtggtgaagg ccaagaagat gagcgagaag gaaggcgccc actacatcga cttccgggag     2160

atcctggccc agaccatgtg caaggaggcc gaaaagaccg cagtgaacaa ggtgagacgc     2220

gccttcttcc accaccacct gaagttcgtg attgacgagt tcggcctgtt cagcgacgtg     2280

atgaagaagt acggcatcga gaaggaatgg aagttccctg tcaag                     2325


<210> 2
<211> 775
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> MOD_RES
<222> (672)..(672)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (676)..(676)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (751)..(751)
<223> Any amino acid

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 2
Met Ala Gln Val Ser Lys Gln Thr Ser Lys Lys Arg Glu Leu Ser Ile 
1               5                   10                  15      


Asp Glu Tyr Gln Gly Ala Arg Lys Trp Cys Phe Thr Ile Ala Phe Asn 
            20                  25                  30          


Lys Ala Leu Val Asn Arg Asp Lys Asn Asp Gly Leu Phe Val Glu Ser 
        35                  40                  45              


Leu Leu Arg His Glu Lys Tyr Ser Lys His Asp Trp Tyr Asp Glu Asp 
    50                  55                  60                  


Thr Arg Ala Leu Ile Lys Cys Ser Thr Gln Ala Ala Asn Ala Lys Ala 
65                  70                  75                  80  


Glu Ala Leu Arg Asn Tyr Phe Ser His Tyr Arg His Ser Pro Gly Cys 
                85                  90                  95      


Leu Thr Phe Thr Ala Glu Asp Glu Leu Arg Thr Ile Met Glu Arg Ala 
            100                 105                 110         


Tyr Glu Arg Ala Ile Phe Glu Cys Arg Arg Arg Glu Thr Glu Val Ile 
        115                 120                 125             


Ile Glu Phe Pro Ser Leu Phe Glu Gly Asp Arg Ile Thr Thr Ala Gly 
    130                 135                 140                 


Val Val Phe Phe Val Ser Phe Phe Val Glu Arg Arg Val Leu Asp Arg 
145                 150                 155                 160 


Leu Tyr Gly Ala Val Ser Gly Leu Lys Lys Asn Glu Gly Gln Tyr Lys 
                165                 170                 175     


Leu Thr Arg Lys Ala Leu Ser Met Tyr Cys Leu Lys Asp Ser Arg Phe 
            180                 185                 190         


Thr Lys Ala Trp Asp Lys Arg Val Leu Leu Phe Arg Asp Ile Leu Ala 
        195                 200                 205             


Gln Leu Gly Arg Ile Pro Ala Glu Ala Tyr Glu Tyr Tyr His Gly Glu 
    210                 215                 220                 


Gln Gly Asp Lys Lys Arg Ala Asn Asp Asn Glu Gly Thr Asn Pro Lys 
225                 230                 235                 240 


Arg His Lys Asp Lys Phe Ile Glu Phe Ala Leu His Tyr Leu Glu Ala 
                245                 250                 255     


Gln His Ser Glu Ile Cys Phe Gly Arg Arg His Ile Val Arg Glu Glu 
            260                 265                 270         


Ala Gly Ala Gly Asp Glu His Lys Lys His Arg Thr Lys Gly Lys Val 
        275                 280                 285             


Val Val Asp Phe Ser Lys Lys Asp Glu Asp Gln Ser Tyr Tyr Ile Ser 
    290                 295                 300                 


Lys Asn Asn Val Ile Val Arg Ile Asp Lys Asn Ala Gly Pro Arg Ser 
305                 310                 315                 320 


Tyr Arg Met Gly Leu Asn Glu Leu Lys Tyr Leu Val Leu Leu Ser Leu 
                325                 330                 335     


Gln Gly Lys Gly Asp Asp Ala Ile Ala Lys Leu Tyr Arg Tyr Arg Gln 
            340                 345                 350         


His Val Glu Asn Ile Leu Asp Val Val Lys Val Thr Asp Lys Asp Asn 
        355                 360                 365             


His Val Phe Leu Pro Arg Phe Val Leu Glu Gln His Gly Ile Gly Arg 
    370                 375                 380                 


Lys Ala Phe Lys Gln Arg Ile Asp Gly Arg Val Lys His Val Arg Gly 
385                 390                 395                 400 


Val Trp Glu Lys Lys Lys Ala Ala Thr Asn Glu Met Thr Leu His Glu 
                405                 410                 415     


Lys Ala Arg Asp Ile Leu Gln Tyr Val Asn Glu Asn Cys Thr Arg Ser 
            420                 425                 430         


Phe Asn Pro Gly Glu Tyr Asn Arg Leu Leu Val Cys Leu Val Gly Lys 
        435                 440                 445             


Asp Val Glu Asn Phe Gln Ala Gly Leu Lys Arg Leu Gln Leu Ala Glu 
    450                 455                 460                 


Arg Ile Asp Gly Arg Val Tyr Ser Ile Phe Ala Gln Thr Ser Thr Ile 
465                 470                 475                 480 


Asn Glu Met His Gln Val Val Cys Asp Gln Ile Leu Asn Arg Leu Cys 
                485                 490                 495     


Arg Ile Gly Asp Gln Lys Leu Tyr Asp Tyr Val Gly Leu Gly Lys Lys 
            500                 505                 510         


Asp Glu Ile Asp Tyr Lys Gln Lys Val Ala Trp Phe Lys Glu His Ile 
        515                 520                 525             


Ser Ile Arg Arg Gly Phe Leu Arg Lys Lys Phe Trp Tyr Asp Ser Lys 
    530                 535                 540                 


Lys Gly Phe Ala Lys Leu Val Glu Glu His Leu Glu Ser Gly Gly Gly 
545                 550                 555                 560 


Gln Arg Asp Val Gly Leu Asp Lys Lys Tyr Tyr His Ile Asp Ala Ile 
                565                 570                 575     


Gly Arg Phe Glu Gly Ala Asn Pro Ala Leu Tyr Glu Thr Leu Ala Arg 
            580                 585                 590         


Asp Arg Leu Cys Leu Met Met Ala Gln Tyr Phe Leu Gly Ser Val Arg 
        595                 600                 605             


Lys Glu Leu Gly Asn Lys Ile Val Trp Ser Asn Asp Ser Ile Glu Leu 
    610                 615                 620                 


Pro Val Glu Gly Ser Val Gly Asn Glu Lys Ser Ile Val Phe Ser Val 
625                 630                 635                 640 


Ser Asp Tyr Gly Lys Leu Tyr Val Leu Asp Asp Ala Glu Phe Leu Gly 
                645                 650                 655     


Arg Ile Cys Glu Tyr Phe Met Pro His Glu Lys Gly Lys Ile Arg Xaa 
            660                 665                 670         


His Thr Val Xaa Glu Lys Gly Phe Arg Ala Tyr Asn Asp Leu Gln Lys 
        675                 680                 685             


Lys Cys Val Glu Ala Val Leu Ala Phe Glu Glu Lys Val Val Lys Ala 
    690                 695                 700                 


Lys Lys Met Ser Glu Lys Glu Gly Ala His Tyr Ile Asp Phe Arg Glu 
705                 710                 715                 720 


Ile Leu Ala Gln Thr Met Cys Lys Glu Ala Glu Lys Thr Ala Val Asn 
                725                 730                 735     


Lys Val Arg Arg Ala Phe Phe His His His Leu Lys Phe Val Xaa Asp 
            740                 745                 750         


Glu Phe Gly Leu Phe Ser Asp Val Met Lys Lys Tyr Gly Ile Glu Lys 
        755                 760                 765             


Glu Trp Lys Phe Pro Val Lys 
    770                 775 


<210> 3
<211> 775
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 3
Met Ala Gln Val Ser Lys Gln Thr Ser Lys Lys Arg Glu Leu Ser Ile 
1               5                   10                  15      


Asp Glu Tyr Gln Gly Ala Arg Lys Trp Cys Phe Thr Ile Ala Phe Asn 
            20                  25                  30          


Lys Ala Leu Val Asn Arg Asp Lys Asn Asp Gly Leu Phe Val Glu Ser 
        35                  40                  45              


Leu Leu Arg His Glu Lys Tyr Ser Lys His Asp Trp Tyr Asp Glu Asp 
    50                  55                  60                  


Thr Arg Ala Leu Ile Lys Cys Ser Thr Gln Ala Ala Asn Ala Lys Ala 
65                  70                  75                  80  


Glu Ala Leu Arg Asn Tyr Phe Ser His Tyr Arg His Ser Pro Gly Cys 
                85                  90                  95      


Leu Thr Phe Thr Ala Glu Asp Glu Leu Arg Thr Ile Met Glu Arg Ala 
            100                 105                 110         


Tyr Glu Arg Ala Ile Phe Glu Cys Arg Arg Arg Glu Thr Glu Val Ile 
        115                 120                 125             


Ile Glu Phe Pro Ser Leu Phe Glu Gly Asp Arg Ile Thr Thr Ala Gly 
    130                 135                 140                 


Val Val Phe Phe Val Ser Phe Phe Val Glu Arg Arg Val Leu Asp Arg 
145                 150                 155                 160 


Leu Tyr Gly Ala Val Ser Gly Leu Lys Lys Asn Glu Gly Gln Tyr Lys 
                165                 170                 175     


Leu Thr Arg Lys Ala Leu Ser Met Tyr Cys Leu Lys Asp Ser Arg Phe 
            180                 185                 190         


Thr Lys Ala Trp Asp Lys Arg Val Leu Leu Phe Arg Asp Ile Leu Ala 
        195                 200                 205             


Gln Leu Gly Arg Ile Pro Ala Glu Ala Tyr Glu Tyr Tyr His Gly Glu 
    210                 215                 220                 


Gln Gly Asp Lys Lys Arg Ala Asn Asp Asn Glu Gly Thr Asn Pro Lys 
225                 230                 235                 240 


Arg His Lys Asp Lys Phe Ile Glu Phe Ala Leu His Tyr Leu Glu Ala 
                245                 250                 255     


Gln His Ser Glu Ile Cys Phe Gly Arg Arg His Ile Val Arg Glu Glu 
            260                 265                 270         


Ala Gly Ala Gly Asp Glu His Lys Lys His Arg Thr Lys Gly Lys Val 
        275                 280                 285             


Val Val Asp Phe Ser Lys Lys Asp Glu Asp Gln Ser Tyr Tyr Ile Ser 
    290                 295                 300                 


Lys Asn Asn Val Ile Val Arg Ile Asp Lys Asn Ala Gly Pro Arg Ser 
305                 310                 315                 320 


Tyr Arg Met Gly Leu Asn Glu Leu Lys Tyr Leu Val Leu Leu Ser Leu 
                325                 330                 335     


Gln Gly Lys Gly Asp Asp Ala Ile Ala Lys Leu Tyr Arg Tyr Arg Gln 
            340                 345                 350         


His Val Glu Asn Ile Leu Asp Val Val Lys Val Thr Asp Lys Asp Asn 
        355                 360                 365             


His Val Phe Leu Pro Arg Phe Val Leu Glu Gln His Gly Ile Gly Arg 
    370                 375                 380                 


Lys Ala Phe Lys Gln Arg Ile Asp Gly Arg Val Lys His Val Arg Gly 
385                 390                 395                 400 


Val Trp Glu Lys Lys Lys Ala Ala Thr Asn Glu Met Thr Leu His Glu 
                405                 410                 415     


Lys Ala Arg Asp Ile Leu Gln Tyr Val Asn Glu Asn Cys Thr Arg Ser 
            420                 425                 430         


Phe Asn Pro Gly Glu Tyr Asn Arg Leu Leu Val Cys Leu Val Gly Lys 
        435                 440                 445             


Asp Val Glu Asn Phe Gln Ala Gly Leu Lys Arg Leu Gln Leu Ala Glu 
    450                 455                 460                 


Arg Ile Asp Gly Arg Val Tyr Ser Ile Phe Ala Gln Thr Ser Thr Ile 
465                 470                 475                 480 


Asn Glu Met His Gln Val Val Cys Asp Gln Ile Leu Asn Arg Leu Cys 
                485                 490                 495     


Arg Ile Gly Asp Gln Lys Leu Tyr Asp Tyr Val Gly Leu Gly Lys Lys 
            500                 505                 510         


Asp Glu Ile Asp Tyr Lys Gln Lys Val Ala Trp Phe Lys Glu His Ile 
        515                 520                 525             


Ser Ile Arg Arg Gly Phe Leu Arg Lys Lys Phe Trp Tyr Asp Ser Lys 
    530                 535                 540                 


Lys Gly Phe Ala Lys Leu Val Glu Glu His Leu Glu Ser Gly Gly Gly 
545                 550                 555                 560 


Gln Arg Asp Val Gly Leu Asp Lys Lys Tyr Tyr His Ile Asp Ala Ile 
                565                 570                 575     


Gly Arg Phe Glu Gly Ala Asn Pro Ala Leu Tyr Glu Thr Leu Ala Arg 
            580                 585                 590         


Asp Arg Leu Cys Leu Met Met Ala Gln Tyr Phe Leu Gly Ser Val Arg 
        595                 600                 605             


Lys Glu Leu Gly Asn Lys Ile Val Trp Ser Asn Asp Ser Ile Glu Leu 
    610                 615                 620                 


Pro Val Glu Gly Ser Val Gly Asn Glu Lys Ser Ile Val Phe Ser Val 
625                 630                 635                 640 


Ser Asp Tyr Gly Lys Leu Tyr Val Leu Asp Asp Ala Glu Phe Leu Gly 
                645                 650                 655     


Arg Ile Cys Glu Tyr Phe Met Pro His Glu Lys Gly Lys Ile Arg Ala 
            660                 665                 670         


His Thr Val Ala Glu Lys Gly Phe Arg Ala Tyr Asn Asp Leu Gln Lys 
        675                 680                 685             


Lys Cys Val Glu Ala Val Leu Ala Phe Glu Glu Lys Val Val Lys Ala 
    690                 695                 700                 


Lys Lys Met Ser Glu Lys Glu Gly Ala His Tyr Ile Asp Phe Arg Glu 
705                 710                 715                 720 


Ile Leu Ala Gln Thr Met Cys Lys Glu Ala Glu Lys Thr Ala Val Asn 
                725                 730                 735     


Lys Val Arg Arg Ala Phe Phe His His His Leu Lys Phe Val Ile Asp 
            740                 745                 750         


Glu Phe Gly Leu Phe Ser Asp Val Met Lys Lys Tyr Gly Ile Glu Lys 
        755                 760                 765             


Glu Trp Lys Phe Pro Val Lys 
    770                 775 


<210> 4
<211> 775
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown:
      Cas13e sequence"

<400> 4
Met Ala Gln Val Ser Lys Gln Thr Ser Lys Lys Arg Glu Leu Ser Ile 
1               5                   10                  15      


Asp Glu Tyr Gln Gly Ala Arg Lys Trp Cys Phe Thr Ile Ala Phe Asn 
            20                  25                  30          


Lys Ala Leu Val Asn Arg Asp Lys Asn Asp Gly Leu Phe Val Glu Ser 
        35                  40                  45              


Leu Leu Arg His Glu Lys Tyr Ser Lys His Asp Trp Tyr Asp Glu Asp 
    50                  55                  60                  


Thr Arg Ala Leu Ile Lys Cys Ser Thr Gln Ala Ala Asn Ala Lys Ala 
65                  70                  75                  80  


Glu Ala Leu Arg Asn Tyr Phe Ser His Tyr Arg His Ser Pro Gly Cys 
                85                  90                  95      


Leu Thr Phe Thr Ala Glu Asp Glu Leu Arg Thr Ile Met Glu Arg Ala 
            100                 105                 110         


Tyr Glu Arg Ala Ile Phe Glu Cys Arg Arg Arg Glu Thr Glu Val Ile 
        115                 120                 125             


Ile Glu Phe Pro Ser Leu Phe Glu Gly Asp Arg Ile Thr Thr Ala Gly 
    130                 135                 140                 


Val Val Phe Phe Val Ser Phe Phe Val Glu Arg Arg Val Leu Asp Arg 
145                 150                 155                 160 


Leu Tyr Gly Ala Val Ser Gly Leu Lys Lys Asn Glu Gly Gln Tyr Lys 
                165                 170                 175     


Leu Thr Arg Lys Ala Leu Ser Met Tyr Cys Leu Lys Asp Ser Arg Phe 
            180                 185                 190         


Thr Lys Ala Trp Asp Lys Arg Val Leu Leu Phe Arg Asp Ile Leu Ala 
        195                 200                 205             


Gln Leu Gly Arg Ile Pro Ala Glu Ala Tyr Glu Tyr Tyr His Gly Glu 
    210                 215                 220                 


Gln Gly Asp Lys Lys Arg Ala Asn Asp Asn Glu Gly Thr Asn Pro Lys 
225                 230                 235                 240 


Arg His Lys Asp Lys Phe Ile Glu Phe Ala Leu His Tyr Leu Glu Ala 
                245                 250                 255     


Gln His Ser Glu Ile Cys Phe Gly Arg Arg His Ile Val Arg Glu Glu 
            260                 265                 270         


Ala Gly Ala Gly Asp Glu His Lys Lys His Arg Thr Lys Gly Lys Val 
        275                 280                 285             


Val Val Asp Phe Ser Lys Lys Asp Glu Asp Gln Ser Tyr Tyr Ile Ser 
    290                 295                 300                 


Lys Asn Asn Val Ile Val Arg Ile Asp Lys Asn Ala Gly Pro Arg Ser 
305                 310                 315                 320 


Tyr Arg Met Gly Leu Asn Glu Leu Lys Tyr Leu Val Leu Leu Ser Leu 
                325                 330                 335     


Gln Gly Lys Gly Asp Asp Ala Ile Ala Lys Leu Tyr Arg Tyr Arg Gln 
            340                 345                 350         


His Val Glu Asn Ile Leu Asp Val Val Lys Val Thr Asp Lys Asp Asn 
        355                 360                 365             


His Val Phe Leu Pro Arg Phe Val Leu Glu Gln His Gly Ile Gly Arg 
    370                 375                 380                 


Lys Ala Phe Lys Gln Arg Ile Asp Gly Arg Val Lys His Val Arg Gly 
385                 390                 395                 400 


Val Trp Glu Lys Lys Lys Ala Ala Thr Asn Glu Met Thr Leu His Glu 
                405                 410                 415     


Lys Ala Arg Asp Ile Leu Gln Tyr Val Asn Glu Asn Cys Thr Arg Ser 
            420                 425                 430         


Phe Asn Pro Gly Glu Tyr Asn Arg Leu Leu Val Cys Leu Val Gly Lys 
        435                 440                 445             


Asp Val Glu Asn Phe Gln Ala Gly Leu Lys Arg Leu Gln Leu Ala Glu 
    450                 455                 460                 


Arg Ile Asp Gly Arg Val Tyr Ser Ile Phe Ala Gln Thr Ser Thr Ile 
465                 470                 475                 480 


Asn Glu Met His Gln Val Val Cys Asp Gln Ile Leu Asn Arg Leu Cys 
                485                 490                 495     


Arg Ile Gly Asp Gln Lys Leu Tyr Asp Tyr Val Gly Leu Gly Lys Lys 
            500                 505                 510         


Asp Glu Ile Asp Tyr Lys Gln Lys Val Ala Trp Phe Lys Glu His Ile 
        515                 520                 525             


Ser Ile Arg Arg Gly Phe Leu Arg Lys Lys Phe Trp Tyr Asp Ser Lys 
    530                 535                 540                 


Lys Gly Phe Ala Lys Leu Val Glu Glu His Leu Glu Ser Gly Gly Gly 
545                 550                 555                 560 


Gln Arg Asp Val Gly Leu Asp Lys Lys Tyr Tyr His Ile Asp Ala Ile 
                565                 570                 575     


Gly Arg Phe Glu Gly Ala Asn Pro Ala Leu Tyr Glu Thr Leu Ala Arg 
            580                 585                 590         


Asp Arg Leu Cys Leu Met Met Ala Gln Tyr Phe Leu Gly Ser Val Arg 
        595                 600                 605             


Lys Glu Leu Gly Asn Lys Ile Val Trp Ser Asn Asp Ser Ile Glu Leu 
    610                 615                 620                 


Pro Val Glu Gly Ser Val Gly Asn Glu Lys Ser Ile Val Phe Ser Val 
625                 630                 635                 640 


Ser Asp Tyr Gly Lys Leu Tyr Val Leu Asp Asp Ala Glu Phe Leu Gly 
                645                 650                 655     


Arg Ile Cys Glu Tyr Phe Met Pro His Glu Lys Gly Lys Ile Arg Tyr 
            660                 665                 670         


His Thr Val Tyr Glu Lys Gly Phe Arg Ala Tyr Asn Asp Leu Gln Lys 
        675                 680                 685             


Lys Cys Val Glu Ala Val Leu Ala Phe Glu Glu Lys Val Val Lys Ala 
    690                 695                 700                 


Lys Lys Met Ser Glu Lys Glu Gly Ala His Tyr Ile Asp Phe Arg Glu 
705                 710                 715                 720 


Ile Leu Ala Gln Thr Met Cys Lys Glu Ala Glu Lys Thr Ala Val Asn 
                725                 730                 735     


Lys Val Arg Arg Ala Phe Phe His His His Leu Lys Phe Val Ile Asp 
            740                 745                 750         


Glu Phe Gly Leu Phe Ser Asp Val Met Lys Lys Tyr Gly Ile Glu Lys 
        755                 760                 765             


Glu Trp Lys Phe Pro Val Lys 
    770                 775 


<210> 5
<211> 2325
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 5
atggcccagg tgagcaagca gacctccaag aagagggagc tgagcatcga cgagtaccag       60

ggcgcccgga agtggtgctt caccattgcc ttcaacaagg ccctggtgaa ccgggacaag      120

aacgacggcc tgttcgtgga aagcctgctg agacacgaga agtacagcaa gcacgactgg      180

tacgacgaag atacccgggc cctgatcaag tgcagcaccc aggccgccaa cgccaaggct      240

gaagccctgc ggaactactt cagtcactac cggcatagcc ctggctgcct gaccttcacc      300

gccgaggacg aactgcggac catcatggag agagcctatg agcgggccat cttcgagtgc      360

agaagaagag agacagaggt gatcatcgag tttcccagcc tgttcgaggg cgaccggatc      420

accaccgccg gcgtggtgtt tttcgtgagc tttttcgtgg aaagaagagt gctggatcgg      480

ctgtatggag ccgtgtccgg cctgaagaag aatgagggac agtacaagct gacccggaag      540

gccctgagca tgtactgcct gaaggacagc agattcacca aggcctggga taagcgggtg      600

ctgctgttca gagacatcct ggcccagctg ggaagaatcc ccgccgaggc ctacgagtac      660

taccacggcg agcagggtga taagaagaga gctaacgaca atgagggcac aaatcccaag      720

cggcacaagg acaagttcat cgaatttgca ctgcactacc tggaagccca gcacagcgag      780

atctgcttcg gcagacgcca catcgtgcgg gaagaggccg gcgccggcga tgagcacaag      840

aagcaccgga ccaagggaaa ggtggtggtg gacttcagca agaaggacga ggaccagagc      900

tactatatct ccaagaacaa cgtgatcgtg cggatcgaca agaacgccgg ccctagaagc      960

taccggatgg gcctgaacga gctgaagtac ctcgtgctgc tgagcctgca ggggaagggc     1020

gacgatgcca tcgccaagct gtacagatac agacagcacg tggagaacat cctggatgtg     1080

gtgaaggtga ccgataagga taaccacgtg ttcctgcccc gcttcgtgct ggagcagcac     1140

ggcatcggca gaaaggcctt caagcagcgg atcgatggac gggtgaagca cgtgcggggc     1200

gtgtgggaga agaagaaggc cgccaccaat gaaatgaccc tgcacgagaa ggccagagac     1260

atcctgcagt acgtgaacga aaactgcacc cggtccttca accctggcga atacaacaga     1320

ctgctggtgt gcctggtggg caaggacgtg gagaactttc aggccggcct gaagcggctg     1380

cagctggccg aaaggatcga tggccgggtg tactccatct tcgcccagac cagcaccatc     1440

aatgagatgc accaggtggt gtgcgaccag atcctgaacc ggctgtgcag aatcggcgac     1500

cagaagctgt acgattacgt gggactgggc aagaaggacg aaatcgacta caagcagaag     1560

gtggcctggt tcaaggagca catcagcatc cggagaggat tcctgagaaa gaagttctgg     1620

tacgatagca agaagggatt cgcaaagctg gtggaggaac acctggagtc cggcggcggc     1680

cagcgcgacg tgggcctgga caagaagtac taccacatcg acgccatcgg cagattcgag     1740

ggcgccaacc ccgccctgta cgagaccctg gccagagatc ggctgtgcct catgatggcc     1800

cagtacttcc tgggcagcgt gagaaaggaa ctgggcaaca agattgtgtg gagcaacgac     1860

agcatcgaac tgcctgtgga aggctctgtg ggaaatgaga agagcatcgt gttctccgtg     1920

tctgactacg gcaagctgta cgtgctggac gatgccgaat tcctgggccg gatctgcgaa     1980

tacttcatgc cccacgaaaa gggcaagatc cgggcccaca cagtggccga aaagggcttt     2040

agagcataca acgacctgca gaagaagtgc gtggaggccg tgctggcttt cgaagagaag     2100

gtggtgaagg ccaagaagat gagcgagaag gaaggcgccc actacatcga cttccgggag     2160

atcctggccc agaccatgtg caaggaggcc gaaaagaccg cagtgaacaa ggtgagacgc     2220

gccttcttcc accaccacct gaagttcgtg attgacgagt tcggcctgtt cagcgacgtg     2280

atgaagaagt acggcatcga gaaggaatgg aagttccctg tcaag                     2325


<210> 6
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 6
gctggagcag cccccgattt gtggggtgat tacagc                                 36


<210> 7
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 7
gtgctgtagg aagctcatct ctcctatgtg                                        30


<210> 8
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 8
ggtactcctg gaagatgtcc accagggtct                                        30


<210> 9

<400> 9
000


<210> 10
<211> 141
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 10
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc t                                                141


<210> 11
<211> 141
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 11
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag ctgcctgcag g                                                141


<210> 12
<211> 261
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 12
taggtcttga aaggagtggg aattggctcc ggtgcccgtc agtgggcaga gcgcacatcg       60

cccacagtcc ccgagaagtt ggggggaggg gtcggcaatt gatccggtgc ctagagaagg      120

tggcgcgggg taaactggga aagtgatgtc gtgtactggc tccgcctttt tcccgagggt      180

gggggagaac cgtatataag tgcagtagtc gccgtgaacg ttctttttcg caacgggttt      240

gccgccagaa cacagggttg g                                                261


<210> 13
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 13
gccaccatg                                                                9


<210> 14
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 14
cccaagaaga agcggaaggt g                                                 21


<210> 15
<211> 135
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 15
aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca       60

aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct      120

tatcatgtct ggatc                                                       135


<210> 16
<211> 241
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 16
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattggaa ttaatttgac tgtaaacaca aagatattag tacaaaatac gtgacgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga      240

c                                                                      241


<210> 17
<211> 3569
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 17
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccatc gatggcgcgc cggattcgac attgattatt      180

gataggtctt gaaaggagtg ggaattggct ccggtgcccg tcagtgggca gagcgcacat      240

cgcccacagt ccccgagaag ttggggggag gggtcggcaa ttgatccggt gcctagagaa      300

ggtggcgcgg ggtaaactgg gaaagtgatg tcgtgtactg gctccgcctt tttcccgagg      360

gtgggggaga accgtatata agtgcagtag tcgccgtgaa cgttcttttt cgcaacgggt      420

ttgccgccag aacacagggt tggaccggtg ccaccatgcc caagaagaag cggaaggtgg      480

cccaggtgag caagcagacc tccaagaaga gggagctgag catcgacgag taccagggcg      540

cccggaagtg gtgcttcacc attgccttca acaaggccct ggtgaaccgg gacaagaacg      600

acggcctgtt cgtggaaagc ctgctgagac acgagaagta cagcaagcac gactggtacg      660

acgaagatac ccgggccctg atcaagtgca gcacccaggc cgccaacgcc aaggctgaag      720

ccctgcggaa ctacttcagt cactaccggc atagccctgg ctgcctgacc ttcaccgccg      780

aggacgaact gcggaccatc atggagagag cctatgagcg ggccatcttc gagtgcagaa      840

gaagagagac agaggtgatc atcgagtttc ccagcctgtt cgagggcgac cggatcacca      900

ccgccggcgt ggtgtttttc gtgagctttt tcgtggaaag aagagtgctg gatcggctgt      960

atggagccgt gtccggcctg aagaagaatg agggacagta caagctgacc cggaaggccc     1020

tgagcatgta ctgcctgaag gacagcagat tcaccaaggc ctgggataag cgggtgctgc     1080

tgttcagaga catcctggcc cagctgggaa gaatccccgc cgaggcctac gagtactacc     1140

acggcgagca gggtgataag aagagagcta acgacaatga gggcacaaat cccaagcggc     1200

acaaggacaa gttcatcgaa tttgcactgc actacctgga agcccagcac agcgagatct     1260

gcttcggcag acgccacatc gtgcgggaag aggccggcgc cggcgatgag cacaagaagc     1320

accggaccaa gggaaaggtg gtggtggact tcagcaagaa ggacgaggac cagagctact     1380

atatctccaa gaacaacgtg atcgtgcgga tcgacaagaa cgccggccct agaagctacc     1440

ggatgggcct gaacgagctg aagtacctcg tgctgctgag cctgcagggg aagggcgacg     1500

atgccatcgc caagctgtac agatacagac agcacgtgga gaacatcctg gatgtggtga     1560

aggtgaccga taaggataac cacgtgttcc tgccccgctt cgtgctggag cagcacggca     1620

tcggcagaaa ggccttcaag cagcggatcg atggacgggt gaagcacgtg cggggcgtgt     1680

gggagaagaa gaaggccgcc accaatgaaa tgaccctgca cgagaaggcc agagacatcc     1740

tgcagtacgt gaacgaaaac tgcacccggt ccttcaaccc tggcgaatac aacagactgc     1800

tggtgtgcct ggtgggcaag gacgtggaga actttcaggc cggcctgaag cggctgcagc     1860

tggccgaaag gatcgatggc cgggtgtact ccatcttcgc ccagaccagc accatcaatg     1920

agatgcacca ggtggtgtgc gaccagatcc tgaaccggct gtgcagaatc ggcgaccaga     1980

agctgtacga ttacgtggga ctgggcaaga aggacgaaat cgactacaag cagaaggtgg     2040

cctggttcaa ggagcacatc agcatccgga gaggattcct gagaaagaag ttctggtacg     2100

atagcaagaa gggattcgca aagctggtgg aggaacacct ggagtccggc ggcggccagc     2160

gcgacgtggg cctggacaag aagtactacc acatcgacgc catcggcaga ttcgagggcg     2220

ccaaccccgc cctgtacgag accctggcca gagatcggct gtgcctcatg atggcccagt     2280

acttcctggg cagcgtgaga aaggaactgg gcaacaagat tgtgtggagc aacgacagca     2340

tcgaactgcc tgtggaaggc tctgtgggaa atgagaagag catcgtgttc tccgtgtctg     2400

actacggcaa gctgtacgtg ctggacgatg ccgaattcct gggccggatc tgcgaatact     2460

tcatgcccca cgaaaagggc aagatccggg cccacacagt ggccgaaaag ggctttagag     2520

catacaacga cctgcagaag aagtgcgtgg aggccgtgct ggctttcgaa gagaaggtgg     2580

tgaaggccaa gaagatgagc gagaaggaag gcgcccacta catcgacttc cgggagatcc     2640

tggcccagac catgtgcaag gaggccgaaa agaccgcagt gaacaaggtg agacgcgcct     2700

tcttccacca ccacctgaag ttcgtgattg acgagttcgg cctgttcagc gacgtgatga     2760

agaagtacgg catcgagaag gaatggaagt tccctgtcaa gcccaagaag aagcggaagg     2820

tgtagaagct taacttgttt attgcagctt ataatggtta caaataaagc aatagcatca     2880

caaatttcac aaataaagca tttttttcac tgcattctag ttgtggtttg tccaaactca     2940

tcaatgtatc ttatcatgtc tggatcacta gtgagggcct atttcccatg attccttcat     3000

atttgcatat acgatacaag gctgttagag agataattgg aattaatttg actgtaaaca     3060

caaagatatt agtacaaaat acgtgacgta gaaagtaata atttcttggg tagtttgcag     3120

ttttaaaatt atgttttaaa atggactatc atatgcttac cgtaacttga aagtatttcg     3180

atttcttggc tttatatatc ttgtggaaag gacgaaacac cggctggagc agcccccgat     3240

ttgtggggtg attacagcgt gctgtaggaa gctcatctct cctatgtggc tggagcagcc     3300

cccgatttgt ggggtgatta cagcggtact cctggaagat gtccaccagg gtctgctgga     3360

gcagcccccg atttgtgggg tgattacagc tttttttacg cgttagttat taatagtgcg     3420

tcggccgcag gaacccctag tgatggagtt ggccactccc tctctgcgcg ctcgctcgct     3480

cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt     3540

gagcgagcga gcgcgcagct gcctgcagg                                       3569


<210> 18

<400> 18
000


<210> 19

<400> 19
000


<210> 20
<211> 7
<212> PRT
<213> Simian virus 40

<400> 20
Pro Lys Lys Lys Arg Lys Val 
1               5           


<210> 21
<211> 16
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Nucleoplasmin bipartite NLS sequence"

<400> 21
Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210> 22
<211> 9
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      C-myc NLS sequence"

<400> 22
Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   


<210> 23
<211> 11
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      C-myc NLS sequence"

<400> 23
Arg Gln Arg Arg Asn Glu Leu Lys Arg Ser Pro 
1               5                   10      


<210> 24
<211> 38
<212> PRT
<213> Homo sapiens

<400> 24
Asn Gln Ser Ser Asn Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly 
1               5                   10                  15      


Arg Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro 
            20                  25                  30          


Arg Asn Gln Gly Gly Tyr 
        35              


<210> 25
<211> 42
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      IBB domain from importin-alpha sequence"

<400> 25
Arg Met Arg Ile Glx Phe Lys Asn Lys Gly Lys Asp Thr Ala Glu Leu 
1               5                   10                  15      


Arg Arg Arg Arg Val Glu Val Ser Val Glu Leu Arg Lys Ala Lys Lys 
            20                  25                  30          


Asp Glu Gln Ile Leu Lys Arg Arg Asn Val 
        35                  40          


<210> 26
<211> 8
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Myoma T protein sequence"

<400> 26
Val Ser Arg Lys Arg Pro Arg Pro 
1               5               


<210> 27
<211> 8
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Myoma T protein sequence"

<400> 27
Pro Pro Lys Lys Ala Arg Glu Asp 
1               5               


<210> 28
<211> 8
<212> PRT
<213> Homo sapiens

<400> 28
Pro Gln Pro Lys Lys Lys Pro Leu 
1               5               


<210> 29
<211> 5
<212> PRT
<213> Influenza virus

<400> 29
Asp Arg Leu Arg Arg 
1               5   


<210> 30
<211> 7
<212> PRT
<213> Influenza virus

<400> 30
Pro Lys Gln Lys Lys Arg Lys 
1               5           


<210> 31
<211> 10
<212> PRT
<213> Hepatitis delta virus

<400> 31
Arg Lys Leu Lys Lys Lys Ile Lys Lys Leu 
1               5                   10  


<210> 32
<211> 10
<212> PRT
<213> Mus musculus

<400> 32
Arg Glu Lys Lys Lys Phe Leu Lys Arg Arg 
1               5                   10  


<210> 33
<211> 20
<212> PRT
<213> Homo sapiens

<400> 33
Lys Arg Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys 
1               5                   10                  15      


Lys Ser Lys Lys 
            20  


<210> 34
<211> 17
<212> PRT
<213> Homo sapiens

<400> 34
Arg Lys Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys 
1               5                   10                  15      


Lys 
    


<210> 35
<211> 6
<212> PRT
<213> Homo sapiens

<400> 35
Pro Lys Leu Lys Arg Gln 
1               5       


<210> 36
<211> 4
<212> PRT
<213> Homo sapiens

<400> 36
Arg Pro Arg Lys 
1               


<210> 37
<211> 8
<212> PRT
<213> Chicken anemia virus

<400> 37
Arg Arg Ala Arg Arg Pro Arg Gly 
1               5               


<210> 38
<211> 21
<212> PRT
<213> Homo sapiens

<400> 38
Gly Lys Arg Lys Leu Ile Thr Ser Glu Glu Glu Arg Ser Pro Ala Lys 
1               5                   10                  15      


Arg Gly Arg Lys Ser 
            20      


<210> 39
<211> 22
<212> PRT
<213> Homo sapiens

<400> 39
Lys Gly Lys Lys Gly Arg Thr Gln Lys Glu Lys Lys Ala Ala Arg Ala 
1               5                   10                  15      


Arg Ser Lys Gly Lys Asn 
            20          


<210> 40
<211> 28
<212> PRT
<213> Homo sapiens

<400> 40
Arg Lys Arg Cys Ala Ala Gly Val Gly Gly Gly Pro Ala Gly Cys Pro 
1               5                   10                  15      


Ala Pro Gly Ser Thr Pro Leu Lys Lys Pro Arg Arg 
            20                  25              


<210> 41
<211> 36
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown:
      NLS ERK5 sequence"

<400> 41
Arg Lys Pro Val Thr Ala Gln Glu Arg Gln Arg Glu Arg Glu Glu Lys 
1               5                   10                  15      


Arg Arg Arg Arg Gln Glu Arg Ala Lys Glu Arg Glu Lys Arg Arg Gln 
            20                  25                  30          


Glu Arg Glu Arg 
        35      


<210> 42
<211> 27
<212> PRT
<213> Saccharomyces cerevisiae

<400> 42
Arg Ser Gly Gly Asn His Arg Arg Asn Gly Arg Gly Gly Arg Gly Gly 
1               5                   10                  15      


Tyr Asn Arg Arg Asn Asn Gly Tyr His Pro Tyr 
            20                  25          


<210> 43
<211> 27
<212> PRT
<213> Human betaherpesvirus 5

<400> 43
Thr Leu Leu Leu Arg Glu Thr Met Asn Asn Leu Gly Val Ser Asp His 
1               5                   10                  15      


Ala Val Leu Ser Arg Lys Thr Pro Gln Pro Tyr 
            20                  25          


<210> 44
<211> 18
<212> PRT
<213> Homo sapiens

<400> 44
Pro Gly Lys Met Asp Lys Gly Glu His Arg Gln Glu Arg Arg Asp Arg 
1               5                   10                  15      


Pro Tyr 
        


<210> 45
<211> 21
<212> PRT
<213> Homo sapiens

<400> 45
Gly Lys Lys Lys Lys Gly Lys Pro Gly Lys Arg Arg Glu Gln Arg Lys 
1               5                   10                  15      


Lys Lys Arg Arg Thr 
            20      


<210> 46
<211> 27
<212> PRT
<213> Saccharomyces cerevisiae

<400> 46
Ser Ala Asn Lys Val Thr Lys Asn Lys Ser Asn Ser Ser Pro Tyr Leu 
1               5                   10                  15      


Asn Lys Arg Lys Gly Lys Pro Gly Pro Asp Ser 
            20                  25          


<210> 47
<211> 43
<212> PRT
<213> Homo sapiens

<400> 47
Val His Ser His Lys Lys Lys Lys Ile Pro Thr Ser Pro Thr Phe Thr 
1               5                   10                  15      


Thr Pro Lys Thr Leu Thr Leu Arg Arg Gln Pro Lys Tyr Pro Arg Lys 
            20                  25                  30          


Ser Ala Pro Arg Arg Asn Lys Leu Asp His Tyr 
        35                  40              


<210> 48
<211> 10
<212> PRT
<213> Homo sapiens

<400> 48
Arg Lys His Lys Thr Asn Arg Lys Pro Arg 
1               5                   10  


<210> 49
<211> 6660
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 49
gaattcactg gccgtcgttt tacaacgtcg tgactgggaa aaccctggcg ttacccaact       60

taatcgcctt gcagcacatc cccctttcgc cagctggcgt aatagcgaag aggcccgcac      120

cgatggatcc cgccgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      180

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      240

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      300

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      360

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      420

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      480

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      540

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      600

gcggtaggcg tgtacggtgg gaggtctata taagcagagc tggtttagtg aaccgtcaga      660

tccgatggtg agcaagggcg aggaggataa catggccatc atcaaggagt tcatgcgctt      720

caaggtgcac atggagggct ccgtgaacgg ccacgagttc gagatcgagg gcgagggcga      780

gggccgcccc tacgagggca cccagaccgc caagctgaag gtgaccaagg gtggccccct      840

gcccttcgcc tgggacatcc tgtcccctca gttcatgtac ggctccaagg cctacgtgaa      900

gcaccccgcc gacatccccg actacttgaa gctgtccttc cccgagggct tcaagtggga      960

gcgcgtgatg aacttcgagg acggcggcgt ggtgaccgtg acccaggact cctccctgca     1020

ggacggcgag ttcatctaca aggtgaagct gcgcggcacc aacttcccct ccgacggccc     1080

cgtaatgcag aagaaaacca tgggctggga ggcctcctcc gagcggatgt accccgagga     1140

cggcgccctg aagggcgaga tcaagcagag gctgaagctg aaggacggcg gccactacga     1200

cgctgaggtc aagaccacct acaaggccaa gaagcccgtg cagctgcccg gcgcctacaa     1260

cgtcaacatc aagttggaca tcacctccca caacgaggac tacaccatcg tggaacagta     1320

cgaacgcgcc gagggccgcc actccaccgg cggcatggac gagctgtaca agtaactctt     1380

ggcccggatc cctgtgcctt ctagttgcca gccatctgtt gtttgcccct cccccgtgcc     1440

ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg aggaaattgc     1500

atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc aggacagcaa     1560

gggggaggat tgggaaaaca atagcaggca tgctggggat gcggtgggct ctatggaagc     1620

tagcagcaaa tccttccaga cccaaccaaa ccaatcgtag taaccattca ggaacgcaac     1680

cgcagcttag accaaaacag gaagctatgg gcctgcttag gtgacgtctc tcgtcaggtt     1740

gaatggcatg gtcgctggct ggatgcagaa agctggaagt gtgtgtttac cgcagcatta     1800

aagcagcagg atgttgttcc taaccttgcc gggaatggct ttgtggtaat aggccagtca     1860

accagcagga tgcgtgtagg cgaatttgcg gagctattag agcttataca ggcattcggt     1920

acagagcgtg gcgttaagtg gtcagacgaa gcgagactgg ctctggagtg gaaagcgaga     1980

tggggagaca gggctgcgcc ataaatgtcg ttagtttctc cggtggcagg acgtcagcat     2040

atttgctctg gctaatggag caaaagcgac gggcaggtaa agacgtgcat tacgttttca     2100

tggatacagg ttgtgaacat ccaatgacat atcggtttgt cagggaagtt gtgaagttct     2160

gggatatacc gctcaccgta ttgcaggttg atatcaaccc ggagcttgga cagccaaatg     2220

gttatacggt atgggaacca aaggatattc agacgcgaat gcctgttctg aagccattta     2280

tcgatatggt aaagaaatat ggcactccat acgtcggcgg cgcgttctgc actgacagat     2340

taaaactcgt tcccttcacc aaatactgtg atgaccattt cgggcgaggg aattacacca     2400

cgtggattgg catcagagct gatgaaccga agcggctaaa gccaaagcct ggaatcagat     2460

atcttgctga actgtcagac tttgagaagg aagatatcct cgcatggtgg aagcaacaac     2520

cattcgattt gcaaataccg gaacatctcg gtaactgcat attctgcatt aaaaaatcaa     2580

cgcaaaaaat cggacttgcc tgcaaagatg aggagggatt gcagcgtgtt tttaatgagg     2640

tcatcacggg atcccatgtg cgtgacggac atcgggaaac gccaaaggag attatgtacc     2700

gaggaagaat gtcgctggac ggtatcgcga aaatgtattc agaaaatgat tatcaagccc     2760

tgtatcagga catggtacga gctaaaagat tcgataccgg ctcttgttct gagtcatgcg     2820

aaatatttgg agggcagctt gatttcgact tcgggaggga agctgcgcca tgcgatgtta     2880

tcggtgcggt gaatgcaaag aagataaccg cttccgacca aatcaacctt actggaatcg     2940

atggtgtctc cggtgtgaaa gaacaccaac aggggtgtta ccactaccgc aggaaaagga     3000

ggacgtgccg cgagacagcg acgaagtatc accgacataa tctgcgaaaa ctgcaaatac     3060

cttccaacga aacgcaccag aaataaaccc aagccaatcc caaaagaatc tgacgtaaaa     3120

accttcaact acacggctca cctgtgggat atccggtggc taagacgtcg tgcgaggaaa     3180

acaaggccat tgaccaaaat cgaagttacg aacaagaaag cgtcgagcga gctttaacgt     3240

gcgctaactg cggtcagaag ctgcatgtgc tggaagttca cgtgtgtgag cactgctgcg     3300

cagaactgat gagcgatccg aatagctcga tgcacgagga agaaggccgc cgctaaacca     3360

gcgcgaagac gatgtaaaaa cgatgaatgc cgggaatggt ttcaccctgc attcgctaat     3420

cagtggtggt gctctccaga gtgtggaacc aagatagcac tcgaacgacg aagtaaagaa     3480

cgcgaaaaag cggaaaaagc agcagagaag aaacgacgac gagaggagca gaaacagaaa     3540

gataaactta agattcgaaa actcgcctta aagccccgca gttactggat taaacaagcc     3600

caacaagccg taaacgcctt catcagagaa agagaccgcg acttaccatg tatctcgtgc     3660

ggaacgctca cgtctgctca gtgggatgcc ggacattacc ggacaactgc tgcggcacct     3720

caactccgat ttaatgaacg caatattcac aagcaatgcg tggtgtgcaa ccagcacaaa     3780

agcggaaatc tcgttccgta tcgcgtcgaa ctgattagcc gcatcgggca ggaagcagta     3840

gacgaaatcg aatcaaacca taaccgccat cgctggacta tcgaagagtg caaggcgatc     3900

aaggcagagt accaacagaa actcaaagac ctgcgaaata gcagaagtga ggccgcgcca     3960

cgttctcagt aaaaaccatt ccagacatgc tcgttgaagc atacggaaat cagacagaag     4020

tagcacgcag actgaaatgt agtcgcggta cggtcagaaa atacgttgat gataaagacg     4080

ggaaaatgca cgccatcgtc aacgacgttc tcatggttca tcgcggatgg agtgaaagag     4140

gcccgctatt acgaaaaaat tgatggcagc aaataccgaa atatttgggt agttggcgat     4200

ctgcacggat gctacacgaa cctgatgaac aaactggata cgattggatt cgacaacaaa     4260

aaagacctgc ttatctcggt gggcgatttg gttgatcgtg gtgcagagaa cgttgaatgc     4320

ctggaattaa tcacattccc ctggttcaga gctgtacgtg gaaaccatga gcaaatgatg     4380

attgatggct tatcagagcg tggaaacgtt aatcactggc tgcttaatgg cggtggctgg     4440

ttctttaatc tcgattacga caaagaaatt ctggctaaag ctcttgccca taaagcagat     4500

gaacttccgt taatcatcga actggtgagc aaagataaaa aatatgttat ctgccacgcc     4560

gattatccct ttgacgaata cgagtttgga aagccagttg atcatcagca ggtaatctgg     4620

aaccgcgaac gaatcagcaa ctcacaaaac gggatcgtga aagaaatcaa aggcgcggac     4680

acgttcatct ttggtcatac gccagcagtg aaaccactca agtttgccaa ccaaatgtat     4740

atcgataccg gcgcagtgtt ctgcggaaac ctaacattga ttcaggtaca gggagaaggc     4800

gcgccagact cgaaagcgta gctacgcgga acccctattt gtttattttt ctaaatacat     4860

tcaaatatgt atccgctcat gagacaataa ccctgataaa tgcttcaata atattgaaaa     4920

aggaagagta tgagtattca acatttccgt gtcgccctta ttcccttttt tgcggcattt     4980

tgccttcctg tttttgctca cccagaaacg ctggtgaaag taaaagatgc tgaagatcag     5040

ttgggtgcac gagtgggtta catcgaactg gatctcaaca gcggtaagat ccttgagagt     5100

tttcgccccg aagaacgttt tccaatgatg agcactttta aagttctgct atgtggcgcg     5160

gtattatccc gtattgacgc cgggcaagag caactcggtc gccgcataca ctattctcag     5220

aatgacttgg ttgagtactc accagtcaca gaaaagcatc ttacggatgg catgacagta     5280

agagaattat gcagtgctgc cataaccatg agtgataaca ctgcggccaa cttacttctg     5340

acaacgatcg gaggaccgaa ggagctaacc gcttttttgc acaacatggg ggatcatgta     5400

actcgccttg atcgttggga accggagctg aatgaagcca taccaaacga cgagcgtgac     5460

accacgatgc ctgtagcaat ggcaacaacg ttgcgcaaac tattaactgg cgaactactt     5520

actctagctt cccggcaaca attaatagac tggatggagg cggataaagt tgcaggacca     5580

cttctgcgct cggcccttcc ggctggctgg tttattgctg ataaatctgg agccggtgag     5640

cgtgggtctc gcggtatcat tgcagcactg gggccagatg gtaagccctc ccgtatcgta     5700

gttatctaca cgacggggag tcaggcaact atggatgaac gaaatagaca gatcgctgag     5760

ataggtgcct cactgattaa gcattggtaa ctgtcagacc aagtttactc atatatactt     5820

tagattgatt taaaacttca tttttaattt aaaaggatct aggtgaagat cctttttgat     5880

aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc agaccccgta     5940

gaaaagatca aaggatcttc ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa     6000

acaaaaaaac caccgctacc agcggtggtt tgtttgccgg atcaagagct accaactctt     6060

tttccgaagg taactggctt cagcagagcg cagataccaa atactgttct tctagtgtag     6120

ccgtagttag gccaccactt caagaactct gtagcaccgc ctacatacct cgctctgcta     6180

atcctgttac cagtggctgc tgccagtggc gataagtcgt gtcttaccgg gttggactca     6240

agacgatagt taccggataa ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag     6300

cccagcttgg agcgaacgac ctacaccgaa ctgagatacc tacagcgtga gctatgagaa     6360

agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga     6420

acaggagagc gcacgaggga gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc     6480

gggtttcgcc acctctgact tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc     6540

ctatggaaaa acgccagcaa cgcggccttt ttacggttcc tggccttttg ctggcctttt     6600

gctcacatgt tctttcctgc gttatcccct gattctctcg agatctaggt ttacgacaag     6660


<210> 50
<211> 508
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 50
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      360

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      420

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      480

acggtgggag gtctatataa gcagagct                                         508


<210> 51
<211> 711
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 51
atggtgagca agggcgagga ggataacatg gccatcatca aggagttcat gcgcttcaag       60

gtgcacatgg agggctccgt gaacggccac gagttcgaga tcgagggcga gggcgagggc      120

cgcccctacg agggcaccca gaccgccaag ctgaaggtga ccaagggtgg ccccctgccc      180

ttcgcctggg acatcctgtc ccctcagttc atgtacggct ccaaggccta cgtgaagcac      240

cccgccgaca tccccgacta cttgaagctg tccttccccg agggcttcaa gtgggagcgc      300

gtgatgaact tcgaggacgg cggcgtggtg accgtgaccc aggactcctc cctgcaggac      360

ggcgagttca tctacaaggt gaagctgcgc ggcaccaact tcccctccga cggccccgta      420

atgcagaaga aaaccatggg ctgggaggcc tcctccgagc ggatgtaccc cgaggacggc      480

gccctgaagg gcgagatcaa gcagaggctg aagctgaagg acggcggcca ctacgacgct      540

gaggtcaaga ccacctacaa ggccaagaag cccgtgcagc tgcccggcgc ctacaacgtc      600

aacatcaagt tggacatcac ctcccacaac gaggactaca ccatcgtgga acagtacgaa      660

cgcgccgagg gccgccactc caccggcggc atggacgagc tgtacaagta a               711


<210> 52
<211> 225
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 52
ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc       60

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc      120

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt      180

gggaaaacaa tagcaggcat gctggggatg cggtgggctc tatgg                      225


<210> 53
<211> 12
<212> PRT
<213> Mus musculus

<400> 53
Ser Ala Leu Ile Lys Lys Lys Lys Lys Met Ala Pro 
1               5                   10          


<210> 54
<211> 6
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown:
      NLS-RARalpha sequence"

<400> 54
Arg Asn Lys Lys Lys Lys 
1               5       


<210> 55
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (3)..(3)
<223> /replace="F"

<220>
<221> VARIANT
<222> (4)..(4)
<223> /replace="Y"

<220>
<221> SITE
<222> (1)..(6)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 55
Arg Asn Tyr Phe Ser His 
1               5       


<210> 56
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 56
Arg Asn Tyr Phe Ser His 
1               5       


<210> 57
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 57
Arg Asn Phe Tyr Ser His 
1               5       


<210> 58
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (3)..(3)
<223> /replace="K"

<220>
<221> SITE
<222> (1)..(6)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 58
Arg Asn Ala Ala Leu His 
1               5       


<210> 59
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 59
Arg Ala Phe Phe His His 
1               5       


<210> 60
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 60
Arg Arg Ala Phe Phe His 
1               5       


<210> 61
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 61
Gly Ser Gly Gly Gly Gly Ser 
1               5           


<210> 62
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 62
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 63
<211> 336
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown:
      ADAR1DD-WT sequence"

<400> 63
Ser Leu Gly Thr Gly Asn Arg Cys Val Lys Gly Asp Ser Leu Ser Leu 
1               5                   10                  15      


Lys Gly Glu Thr Val Asn Asp Cys His Ala Glu Ile Ile Ser Arg Arg 
            20                  25                  30          


Gly Phe Ile Arg Phe Leu Tyr Ser Glu Leu Met Lys Tyr Asn Ser Gln 
        35                  40                  45              


Thr Ala Lys Asp Ser Ile Phe Glu Pro Ala Lys Gly Gly Glu Lys Leu 
    50                  55                  60                  


Gln Ile Lys Lys Thr Val Ser Phe His Leu Tyr Ile Ser Thr Ala Pro 
65                  70                  75                  80  


Cys Gly Asp Gly Ala Leu Phe Asp Lys Ser Cys Ser Asp Arg Ala Met 
                85                  90                  95      


Glu Ser Thr Glu Ser Arg His Tyr Pro Val Phe Glu Asn Pro Lys Gln 
            100                 105                 110         


Gly Lys Leu Arg Thr Lys Val Glu Asn Gly Glu Gly Thr Ile Pro Val 
        115                 120                 125             


Glu Ser Ser Asp Ile Val Pro Thr Trp Asp Gly Ile Arg Leu Gly Glu 
    130                 135                 140                 


Arg Leu Arg Thr Met Ser Cys Ser Asp Lys Ile Leu Arg Trp Asn Val 
145                 150                 155                 160 


Leu Gly Leu Gln Gly Ala Leu Leu Thr His Phe Leu Gln Pro Ile Tyr 
                165                 170                 175     


Leu Lys Ser Val Thr Leu Gly Tyr Leu Phe Ser Gln Gly His Leu Thr 
            180                 185                 190         


Arg Ala Ile Cys Cys Arg Val Thr Arg Asp Gly Ser Ala Phe Glu Asp 
        195                 200                 205             


Gly Leu Arg His Pro Phe Ile Val Asn His Pro Lys Val Gly Arg Val 
    210                 215                 220                 


Ser Ile Tyr Asp Ser Lys Arg Gln Ser Gly Lys Thr Lys Glu Thr Ser 
225                 230                 235                 240 


Val Asn Trp Cys Leu Ala Asp Gly Tyr Asp Leu Glu Ile Leu Asp Gly 
                245                 250                 255     


Thr Arg Gly Thr Val Asp Gly Pro Arg Asn Glu Leu Ser Arg Val Ser 
            260                 265                 270         


Lys Lys Asn Ile Phe Leu Leu Phe Lys Lys Leu Cys Ser Phe Arg Tyr 
        275                 280                 285             


Arg Arg Asp Leu Leu Arg Leu Ser Tyr Gly Glu Ala Lys Lys Ala Ala 
    290                 295                 300                 


Arg Asp Tyr Glu Thr Ala Lys Asn Tyr Phe Lys Lys Gly Leu Lys Asp 
305                 310                 315                 320 


Met Gly Tyr Gly Asn Trp Ile Ser Lys Pro Gln Glu Glu Lys Asn Phe 
                325                 330                 335     


<210> 64
<211> 336
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 64
Ser Leu Gly Thr Gly Asn Arg Cys Val Lys Gly Asp Ser Leu Ser Leu 
1               5                   10                  15      


Lys Gly Glu Thr Val Asn Asp Cys His Ala Glu Ile Ile Ser Arg Arg 
            20                  25                  30          


Gly Phe Ile Arg Phe Leu Tyr Ser Glu Leu Met Lys Tyr Asn Ser Gln 
        35                  40                  45              


Thr Ala Lys Asp Ser Ile Phe Glu Pro Ala Lys Gly Gly Glu Lys Leu 
    50                  55                  60                  


Gln Ile Lys Lys Thr Val Ser Phe His Leu Tyr Ile Ser Thr Ala Pro 
65                  70                  75                  80  


Cys Gly Asp Gly Ala Leu Phe Asp Lys Ser Cys Ser Asp Arg Ala Met 
                85                  90                  95      


Glu Ser Thr Glu Ser Arg His Tyr Pro Val Phe Glu Asn Pro Lys Gln 
            100                 105                 110         


Gly Lys Leu Arg Thr Lys Val Glu Asn Gly Gln Gly Thr Ile Pro Val 
        115                 120                 125             


Glu Ser Ser Asp Ile Val Pro Thr Trp Asp Gly Ile Arg Leu Gly Glu 
    130                 135                 140                 


Arg Leu Arg Thr Met Ser Cys Ser Asp Lys Ile Leu Arg Trp Asn Val 
145                 150                 155                 160 


Leu Gly Leu Gln Gly Ala Leu Leu Thr His Phe Leu Gln Pro Ile Tyr 
                165                 170                 175     


Leu Lys Ser Val Thr Leu Gly Tyr Leu Phe Ser Gln Gly His Leu Thr 
            180                 185                 190         


Arg Ala Ile Cys Cys Arg Val Thr Arg Asp Gly Ser Ala Phe Glu Asp 
        195                 200                 205             


Gly Leu Arg His Pro Phe Ile Val Asn His Pro Lys Val Gly Arg Val 
    210                 215                 220                 


Ser Ile Tyr Asp Ser Lys Arg Gln Ser Gly Lys Thr Lys Glu Thr Ser 
225                 230                 235                 240 


Val Asn Trp Cys Leu Ala Asp Gly Tyr Asp Leu Glu Ile Leu Asp Gly 
                245                 250                 255     


Thr Arg Gly Thr Val Asp Gly Pro Arg Asn Glu Leu Ser Arg Val Ser 
            260                 265                 270         


Lys Lys Asn Ile Phe Leu Leu Phe Lys Lys Leu Cys Ser Phe Arg Tyr 
        275                 280                 285             


Arg Arg Asp Leu Leu Arg Leu Ser Tyr Gly Glu Ala Lys Lys Ala Ala 
    290                 295                 300                 


Arg Asp Tyr Glu Thr Ala Lys Asn Tyr Phe Lys Lys Gly Leu Lys Asp 
305                 310                 315                 320 


Met Gly Tyr Gly Asn Trp Ile Ser Lys Pro Gln Glu Glu Lys Asn Phe 
                325                 330                 335     


<210> 65
<211> 385
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown:
      ADAR2DD-WT sequence"

<400> 65
Gln Leu His Leu Pro Gln Val Leu Ala Asp Ala Val Ser Arg Leu Val 
1               5                   10                  15      


Leu Gly Lys Phe Gly Asp Leu Thr Asp Asn Phe Ser Ser Pro His Ala 
            20                  25                  30          


Arg Arg Lys Val Leu Ala Gly Val Val Met Thr Thr Gly Thr Asp Val 
        35                  40                  45              


Lys Asp Ala Lys Val Ile Ser Val Ser Thr Gly Thr Lys Cys Ile Asn 
    50                  55                  60                  


Gly Glu Tyr Met Ser Asp Arg Gly Leu Ala Leu Asn Asp Cys His Ala 
65                  70                  75                  80  


Glu Ile Ile Ser Arg Arg Ser Leu Leu Arg Phe Leu Tyr Thr Gln Leu 
                85                  90                  95      


Glu Leu Tyr Leu Asn Asn Lys Asp Asp Gln Lys Arg Ser Ile Phe Gln 
            100                 105                 110         


Lys Ser Glu Arg Gly Gly Phe Arg Leu Lys Glu Asn Val Gln Phe His 
        115                 120                 125             


Leu Tyr Ile Ser Thr Ser Pro Cys Gly Asp Ala Arg Ile Phe Ser Pro 
    130                 135                 140                 


His Glu Pro Ile Leu Glu Glu Pro Ala Asp Arg His Pro Asn Arg Lys 
145                 150                 155                 160 


Ala Arg Gly Gln Leu Arg Thr Lys Ile Glu Ser Gly Glu Gly Thr Ile 
                165                 170                 175     


Pro Val Arg Ser Asn Ala Ser Ile Gln Thr Trp Asp Gly Val Leu Gln 
            180                 185                 190         


Gly Glu Arg Leu Leu Thr Met Ser Cys Ser Asp Lys Ile Ala Arg Trp 
        195                 200                 205             


Asn Val Val Gly Ile Gln Gly Ser Leu Leu Ser Ile Phe Val Glu Pro 
    210                 215                 220                 


Ile Tyr Phe Ser Ser Ile Ile Leu Gly Ser Leu Tyr His Gly Asp His 
225                 230                 235                 240 


Leu Ser Arg Ala Met Tyr Gln Arg Ile Ser Asn Ile Glu Asp Leu Pro 
                245                 250                 255     


Pro Leu Tyr Thr Leu Asn Lys Pro Leu Leu Ser Gly Ile Ser Asn Ala 
            260                 265                 270         


Glu Ala Arg Gln Pro Gly Lys Ala Pro Asn Phe Ser Val Asn Trp Thr 
        275                 280                 285             


Val Gly Asp Ser Ala Ile Glu Val Ile Asn Ala Thr Thr Gly Lys Asp 
    290                 295                 300                 


Glu Leu Gly Arg Ala Ser Arg Leu Cys Lys His Ala Leu Tyr Cys Arg 
305                 310                 315                 320 


Trp Met Arg Val His Gly Lys Val Pro Ser His Leu Leu Arg Ser Lys 
                325                 330                 335     


Ile Thr Lys Pro Asn Val Tyr His Glu Ser Lys Leu Ala Ala Lys Glu 
            340                 345                 350         


Tyr Gln Ala Ala Lys Ala Arg Leu Phe Thr Ala Phe Ile Lys Ala Gly 
        355                 360                 365             


Leu Gly Ala Trp Val Glu Lys Pro Thr Glu Gln Asp Gln Phe Ser Leu 
    370                 375                 380                 


Thr 
385 


<210> 66
<211> 385
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 66
Gln Leu His Leu Pro Gln Val Leu Ala Asp Ala Val Ser Arg Leu Val 
1               5                   10                  15      


Leu Gly Lys Phe Gly Asp Leu Thr Asp Asn Phe Ser Ser Pro His Ala 
            20                  25                  30          


Arg Arg Lys Val Leu Ala Gly Val Val Met Thr Thr Gly Thr Asp Val 
        35                  40                  45              


Lys Asp Ala Lys Val Ile Ser Val Ser Thr Gly Thr Lys Cys Ile Asn 
    50                  55                  60                  


Gly Glu Tyr Met Ser Asp Arg Gly Leu Ala Leu Asn Asp Cys His Ala 
65                  70                  75                  80  


Glu Ile Ile Ser Arg Arg Ser Leu Leu Arg Phe Leu Tyr Thr Gln Leu 
                85                  90                  95      


Glu Leu Tyr Leu Asn Asn Lys Asp Asp Gln Lys Arg Ser Ile Phe Gln 
            100                 105                 110         


Lys Ser Glu Arg Gly Gly Phe Arg Leu Lys Glu Asn Val Gln Phe His 
        115                 120                 125             


Leu Tyr Ile Ser Thr Ser Pro Cys Gly Asp Ala Arg Ile Phe Ser Pro 
    130                 135                 140                 


His Glu Pro Ile Leu Glu Glu Pro Ala Asp Arg His Pro Asn Arg Lys 
145                 150                 155                 160 


Ala Arg Gly Gln Leu Arg Thr Lys Ile Glu Ser Gly Gln Gly Thr Ile 
                165                 170                 175     


Pro Val Arg Ser Asn Ala Ser Ile Gln Thr Trp Asp Gly Val Leu Gln 
            180                 185                 190         


Gly Glu Arg Leu Leu Thr Met Ser Cys Ser Asp Lys Ile Ala Arg Trp 
        195                 200                 205             


Asn Val Val Gly Ile Gln Gly Ser Leu Leu Ser Ile Phe Val Glu Pro 
    210                 215                 220                 


Ile Tyr Phe Ser Ser Ile Ile Leu Gly Ser Leu Tyr His Gly Asp His 
225                 230                 235                 240 


Leu Ser Arg Ala Met Tyr Gln Arg Ile Ser Asn Ile Glu Asp Leu Pro 
                245                 250                 255     


Pro Leu Tyr Thr Leu Asn Lys Pro Leu Leu Ser Gly Ile Ser Asn Ala 
            260                 265                 270         


Glu Ala Arg Gln Pro Gly Lys Ala Pro Asn Phe Ser Val Asn Trp Thr 
        275                 280                 285             


Val Gly Asp Ser Ala Ile Glu Val Ile Asn Ala Thr Thr Gly Lys Asp 
    290                 295                 300                 


Glu Leu Gly Arg Ala Ser Arg Leu Cys Lys His Ala Leu Tyr Cys Arg 
305                 310                 315                 320 


Trp Met Arg Val His Gly Lys Val Pro Ser His Leu Leu Arg Ser Lys 
                325                 330                 335     


Ile Thr Lys Pro Asn Val Tyr His Glu Ser Lys Leu Ala Ala Lys Glu 
            340                 345                 350         


Tyr Gln Ala Ala Lys Ala Arg Leu Phe Thr Ala Phe Ile Lys Ala Gly 
        355                 360                 365             


Leu Gly Ala Trp Val Glu Lys Pro Thr Glu Gln Asp Gln Phe Ser Leu 
    370                 375                 380                 


Thr 
385 


<210> 67
<211> 198
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown:
      AID-APOBEC1 sequence"

<400> 67
Met Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu Tyr Gln Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Ala Thr Ser Phe Ser Leu Asp Phe Gly Tyr 
        35                  40                  45              


Leu Arg Asn Lys Asn Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Asp 
                85                  90                  95      


Phe Leu Arg Gly Asn Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu Arg Arg 
        115                 120                 125             


Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr Phe Lys Asp Tyr 
    130                 135                 140                 


Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn His Glu Arg Thr Phe Lys 
145                 150                 155                 160 


Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Ser Arg Gln Leu 
                165                 170                 175     


Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 
            180                 185                 190         


Phe Arg Thr Leu Gly Leu 
        195             


<210> 68
<211> 208
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown:
      Lamprey_AID-APOBEC1 sequence"

<400> 68
Met Thr Asp Ala Glu Tyr Val Arg Ile His Glu Lys Leu Asp Ile Tyr 
1               5                   10                  15      


Thr Phe Lys Lys Gln Phe Phe Asn Asn Lys Lys Ser Val Ser His Arg 
            20                  25                  30          


Cys Tyr Val Leu Phe Glu Leu Lys Arg Arg Gly Glu Arg Arg Ala Cys 
        35                  40                  45              


Phe Trp Gly Tyr Ala Val Asn Lys Pro Gln Ser Gly Thr Glu Arg Gly 
    50                  55                  60                  


Ile His Ala Glu Ile Phe Ser Ile Arg Lys Val Glu Glu Tyr Leu Arg 
65                  70                  75                  80  


Asp Asn Pro Gly Gln Phe Thr Ile Asn Trp Tyr Ser Ser Trp Ser Pro 
                85                  90                  95      


Cys Ala Asp Cys Ala Glu Lys Ile Leu Glu Trp Tyr Asn Gln Glu Leu 
            100                 105                 110         


Arg Gly Asn Gly His Thr Leu Lys Ile Trp Ala Cys Lys Leu Tyr Tyr 
        115                 120                 125             


Glu Lys Asn Ala Arg Asn Gln Ile Gly Leu Trp Asn Leu Arg Asp Asn 
    130                 135                 140                 


Gly Val Gly Leu Asn Val Met Val Ser Glu His Tyr Gln Cys Cys Arg 
145                 150                 155                 160 


Lys Ile Phe Ile Gln Ser Ser His Asn Gln Leu Asn Glu Asn Arg Trp 
                165                 170                 175     


Leu Glu Lys Thr Leu Lys Arg Ala Glu Lys Arg Arg Ser Glu Leu Ser 
            180                 185                 190         


Ile Met Ile Gln Val Lys Ile Leu His Thr Thr Lys Ser Pro Ala Val 
        195                 200                 205             


<210> 69
<211> 229
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown:
      APOBEC1_BE1 sequence"

<400> 69
Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys 
225                 


<210> 70
<211> 36
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 70
ggcccaacau gaggaucacc caugucugca ggggcc                                 36


<210> 71
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 71
ggcccaugcu gucuaagaca gcaugggcc                                         29


<210> 72
<211> 34
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 72
ggcccuaagg guuuauaugg aaacccuuag ggcc                                   34


<210> 73
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 73
gagggcagaa tcatcacgaa g                                                 21


<210> 74
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 74
gtgaggtttg atccgcataa tc                                                22


<210> 75
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 75
ttggtggagc gatttgtctg                                                   20


<210> 76
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 76
gaatggggtt caacgggtta                                                   20


<210> 77
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 77
gtgctgtagg aagctcatct ctcctat                                           27


<210> 78
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 78
gaagatgtcc accagggtct                                                   20


<210> 79
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 79
gctactgccg tccgattgag                                                   20


<210> 80
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 80
cactccaggg cttcatcgtt                                                   20


<210> 81
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      probe"

<400> 81
tccaggagta ccccgacgag atag                                              24


<210> 82
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 82
cggcgagcag ggtgataaga                                                   20


<210> 83
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 83
ccaggtagtg cagtgcaaat t                                                 21


<210> 84
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      probe"

<400> 84
tccttgtgcc gcttgggatt tgtg                                              24


<210> 85
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 85
ggtactcctg gaagatgtcc                                                   20


<210> 86
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 86
tgtaatcacc ccacaaatcg                                                   20


<210> 87
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      probe"

<400> 87
accagggtct gctggagcag cc                                                22


<210> 88
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 88
cctgcaggca g                                                            8


<210> 89
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 89
ttaattaagg                                                              8


<210> 90
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 90
aaagcccggg c                                                            8

