                         б

<110>  Ͼ˹Ƽ޹˾
 
<120>  ʹ˫زϵͳͿ

<130>  BD-C22264WO

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  57
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  Avastinǰеı

<400>  1
atgggctggt cctgcatcat cctgtttctg gtggccaccg ctacaggagt gcactcc          57


<210>  2
<211>  1359
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  Avastinı

<400>  2
gaggtgcagc tggtcgaatc cggcggaggc ctggtgcagc ccggcgggtc tctgcggctg       60

tcttgtgccg cttctggcta caccttcacc aactacggca tgaattgggt cagacaggcc      120

cctggcaagg gcctggaatg ggtgggctgg atcaacacct ataccggcga gcccacctac      180

gccgccgact tcaagcggcg gttcacgttc agcctggata cctccaaatc tacagcctac      240

ctgcagatga actccctgag agccgaggac accgctgtgt actactgcgc caagtaccct      300

cactactacg gctcttctca ctggtatttc gacgtgtggg gccagggaac actggtcaca      360

gtgtcctctg cctctaccaa gggcccttct gtgtttcctc tggcccctag cagcaagtcc      420

acctccggcg gcaccgccgc cctgggctgc ctggtgaagg actacttccc agaacctgtg      480

accgtgtctt ggaactccgg cgctctgacc tctggcgtgc acacatttcc agctgttctg      540

cagtcctccg gactgtactc tctgtcctcc gttgtgaccg tgccttccag cagcttgggc      600

acacagacct acatctgcaa cgtgaaccac aagccttcta acaccaaagt ggataagaag      660

gtggaaccta agtcctgcga caagacccac acctgccctc cttgtcctgc tcctgagctg      720

ctgggcggac cttctgtgtt cctgttccct cctaagccca aggacaccct gatgatctct      780

agaacccccg aggtgacatg cgtggtcgtg gacgtgtctc acgaggatcc tgaagtgaag      840

ttcaactggt acgtggacgg cgtggaagtg cacaacgcca agaccaagcc tagagaggaa      900

cagtacaact ctacctacag agtggtgtcc gtgctgaccg tgctgcacca ggactggctg      960

aacggcaaag agtacaagtg caaggtgtcc aacaaggctc tgcctgctcc tatcgagaag     1020

accatctcca aggccaaagg ccagcctcgc gagcctcaag tgtacaccct gcccccatct     1080

cgggaagaga tgaccaagaa ccaggtgtct ctaacctgtc tggtcaaggg cttctacccc     1140

tccgacatcg ccgtggagtg ggagtccaac ggccagcctg agaacaacta caaaaccacc     1200

cctcccgtgc tggactccga tggctccttc ttcctgtact ccaagctgac cgtggacaag     1260

tccagatggc agcagggcaa cgtgttctcc tgctccgtga tgcacgaggc cctgcataat     1320

cactacaccc agaagtctct gtccctgtct cctggcaag                            1359


<210>  3
<211>  75
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  F2A

<400>  3
ggcagcggcg tgaagcagac cctgaacttc gacctgctga agctggccgg cgacgtggag       60

agcaaccccg gcccc                                                        75


<210>  4
<211>  57
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  Avastinǰеı

<400>  4
atgggctggt cctgcatcat cctgttcctg gtggctaccg ctaccggcgt gcactct          57


<210>  5
<211>  645
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  Avastinı

<400>  5
gatatccaga tgacccagtc tcccagctct ctgtctgctt ctgtgggcga cagagtgacc       60

atcacctgtt ctgcctctca ggacatctcc aactacctga actggtacca gcagaagcct      120

ggcaaggctc ctaaagtgct gatctacttc acctccagcc tgcactccgg agtgcccagc      180

cggttctccg gctctggctc cggcaccgac ttcaccctga caatctcttc tctgcagcct      240

gaggacttcg ccacctacta ctgccagcag tactctaccg tgccttggac cttcggccag      300

ggaaccaaag tggaaatcaa gcggaccgtg gccgctccat ccgtgttcat cttccctcct      360

tccgacgaac agctgaagtc tggcacagcc tccgtggtgt gcctgctgaa caacttctac      420

cctagagagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caactcccaa      480

gagtccgtca ccgagcagga ttccaaggac tccacctact ccctgtcctc cacactgacc      540

ctgtctaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgagctctc ctgtgaccaa gtccttcaac agaggcgagt gttga                      645


<210>  6
<211>  57
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ABTAAǰı

<400>  6
atgggctggt cctgcatcat cctgttcctg gtggccaccg ctaccggagt gcactcc          57


<210>  7
<211>  1335
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ABTAAı

<400>  7
gacgtgcagc tgcaagagtc cggccctggc ctggtgaagc cttcccagtc cctgtccctg       60

acctgcaccg tgaccggcta ctccatcacc tccgactacg cctggaactg gatcagacag      120

ttccccggca acaagctgga atggatgggc tacatcaact actctggaaa caccgactac      180

aacccttctc tgaagtccag atcctctatc accagagata cctccaagaa ccagttcttc      240

ctgcagctga actccgtgac caccggcgac accgccacct actactgcgc cagaggcaac      300

ttcgagggcg ccatggacta ctggggccag ggcacctctg tgacagtgtc ctccgcctct      360

acaaagggcc ccagcgtttt cccactggct ccctgtagca gaagcaccag cgaatctaca      420

gccgctctgg gctgcctggt caaggactac tttcctgagc ctgtgaccgt gtcctggaac      480

tctggcgctc tgacaagcgg agtgcacacc tttccagccg tgctgcaaag cagcggcctg      540

tactctctga gcagcgtggt cacagtgcct agctctagcc tgggcaccaa gacctacacc      600

tgtaatgtgg accacaagcc tagcaacacc aaggtggaca agcgcgtgga atctaagtac      660

ggccctcctt gtcctccatg tcctgcacct gagtttctcg gcggaccctc cgtgttcctg      720

tttcctccaa agcctaagga taccctgatg atcagcagaa cccctgaagt gacctgcgtg      780

gtggtggacg tgtcccaaga ggatcctgag gtgcagttca attggtacgt ggacggcgtg      840

gaagtgcaca acgccaagac caagcctaga gaggaacagt tcaacagcac ctacagagtg      900

gtgtccgtgc tgacagtgct gcaccaggat tggctgaacg gcaaagagta caagtgcaag      960

gtgtccaaca agggcctgcc tagcagcatc gagaaaacca tcagcaaggc caagggccag     1020

ccaagagaac cccaggtgta cacactgcct ccaagccaag aggaaatgac caagaaccag     1080

gtgtccctga cctgcctcgt gaagggattc tacccctccg atatcgccgt ggaatgggag     1140

agcaatggac agcccgagaa caactacaag acaacccctc ctgtgctgga cagcgacggc     1200

tcattcttcc tgtacagcag actgaccgtg gacaagagca gatggcaaga gggcaacgtg     1260

ttctcctgca gcgtgatgca cgaggccctg cacaaccact acacccagaa gtctctgtcc     1320

ctgtctctgg gcaag                                                      1335


<210>  8
<211>  75
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  F2A

<400>  8
ggcagcggcg tgaagcagac cctgaacttc gacctgctga agctggccgg cgacgtggag       60

agcaaccccg gcccc                                                        75


<210>  9
<211>  57
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ABTAAǰı

<400>  9
atgggctggt cctgcatcat cctgttcctg gtggccaccg ctaccggagt gcactcc          57


<210>  10
<211>  645
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ABTAAı

<400>  10
tccatcgtga tgacccagac ccctaagttc ctgctggtgt ctgctggcga cagagtgacc       60

atcacctgca aggcctctca gtccgtgtcc aacgacgtgg cctggtacca gcagaagcct      120

ggccagtctc ccaagctgct gatctactac gcctccaaca gataccccgg cgtgcctgac      180

cggttcaccg gctctggcta cggcaccgac ttcaccttta caatctccac cgtgcaggcc      240

gaggacctgg ccgtgtactt ctgccagcag gactactcct ctccttggac cttcggcggc      300

ggaaccaagc tggaaatcaa gagaaccgtg gccgccccta gcgtgttcat ctttcctccc      360

tctgacgagc agctgaaatc tggcaccgct tccgtggtct gcctgctgaa caacttctac      420

cccagagagg ctaaggtgca gtggaaagtg gacaacgccc tgcagtctgg caactcccaa      480

gaaagcgtga ccgagcagga ctccaaggac tctacataca gcctgtcctc caccctgacc      540

ctgtccaagg ccgattacga gaagcacaag gtctacgctt gtgaagtgac ccaccaggga      600

ctgtcctccc ctgtgaccaa gtctttcaat cggggcgagt gctga                      645


<210>  11
<211>  45
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ĵı

<400>  11
ggcggcggtg gctccggtgg aggtggatct ggcggtggag gatct                       45


<210>  12
<211>  738
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  VEGF VL-VH (scFv)

<400>  12
gatatccagc tgacccagtc tccttctagc ttgtctgcct ctgtgggcga cagagtgacc       60

atcacctgct ccgccagcca ggacatctcc aactacctga actggtacca gcagaagcct      120

ggcaaggctc ctaaggtgct gatctacttc acctcctctc tgcactctgg agtgccctcc      180

cggttcagtg gttctggctc tggcaccgac tttaccctga ccatctcttc cctgcagccc      240

gaggacttcg ccacgtacta ctgccagcag tactccaccg tgccttggac ctttggccag      300

ggcaccaagg tggagatcaa gggcggcggc ggctctggcg gcggaggctc cggcggtggc      360

ggcagcgaag tgcagctggt ggaatccggc ggaggcctgg tgcagcctgg cggatctctg      420

cggctgagct gtgccgcttc tggctacgat ttcacccact acggcatgaa ctgggtgcgg      480

caggcccctg gcaaaggcct ggaatgggtc ggatggatca acacatacac cggcgagcct      540

acctacgctg ccgacttcaa gcggagattc accttcagcc tggacacctc taaatctacc      600

gcctacctgc agatgaactc cctgagagcc gaggataccg ccgtgtacta ctgcgccaag      660

tacccctact attatggcac atctcactgg tatttcgacg tgtggggcca gggcaccctg      720

gtcaccgtgt cctcttga                                                    738


<210>  13
<211>  642
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ABTAAı

<400>  13
tccatcgtga tgacccagac ccctaagttc ctgctggtgt ctgctggcga cagagtgacc       60

atcacctgca aggcctctca gtccgtgtcc aacgacgtgg cctggtacca gcagaagcct      120

ggccagtctc ccaagctgct gatctactac gcctccaaca gataccccgg cgtgcctgac      180

cggttcaccg gctctggcta cggcaccgac ttcaccttta caatctccac cgtgcaggcc      240

gaggacctgg ccgtgtactt ctgccagcag gactactcct ctccttggac cttcggcggc      300

ggaaccaagc tggaaatcaa gagaaccgtg gccgccccta gcgtgttcat ctttcctccc      360

tctgacgagc agctgaaatc tggcaccgct tccgtggtct gcctgctgaa caacttctac      420

cccagagagg ctaaggtgca gtggaaagtg gacaacgccc tgcagtctgg caactcccaa      480

gaaagcgtga ccgagcagga ctccaaggac tctacataca gcctgtcctc caccctgacc      540

ctgtccaagg ccgattacga gaagcacaag gtctacgctt gtgaagtgac ccaccaggga      600

ctgtcctccc ctgtgaccaa gtctttcaat cggggcgagt gc                         642


<210>  14
<211>  36
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ĵı

<400>  14
gaatcgaagt acggacctcc atctccacct agtcca                                 36


<210>  15
<211>  1338
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ABTAAı

<400>  15
gacgtgcagc tgcaagagtc cggccctggc ctggtgaagc cttcccagtc cctgtccctg       60

acctgcaccg tgaccggcta ctccatcacc tccgactacg cctggaactg gatcagacag      120

ttccccggca acaagctgga atggatgggc tacatcaact actctggaaa caccgactac      180

aacccttctc tgaagtccag atcctctatc accagagata cctccaagaa ccagttcttc      240

ctgcagctga actccgtgac caccggcgac accgccacct actactgcgc cagaggcaac      300

ttcgagggcg ccatggacta ctggggccag ggcacctctg tgacagtgtc ctccgcctct      360

acaaagggcc ccagcgtttt cccactggct ccctgtagca gaagcaccag cgaatctaca      420

gccgctctgg gctgcctggt caaggactac tttcctgagc ctgtgaccgt gtcctggaac      480

tctggcgctc tgacaagcgg agtgcacacc tttccagccg tgctgcaaag cagcggcctg      540

tactctctga gcagcgtggt cacagtgcct agctctagcc tgggcaccaa gacctacacc      600

tgtaatgtgg accacaagcc tagcaacacc aaggtggaca agcgcgtgga atctaagtac      660

ggccctcctt gtcctccatg tcctgcacct gagtttctcg gcggaccctc cgtgttcctg      720

tttcctccaa agcctaagga taccctgatg atcagcagaa cccctgaagt gacctgcgtg      780

gtggtggacg tgtcccaaga ggatcctgag gtgcagttca attggtacgt ggacggcgtg      840

gaagtgcaca acgccaagac caagcctaga gaggaacagt tcaacagcac ctacagagtg      900

gtgtccgtgc tgacagtgct gcaccaggat tggctgaacg gcaaagagta caagtgcaag      960

gtgtccaaca agggcctgcc tagcagcatc gagaaaacca tcagcaaggc caagggccag     1020

ccaagagaac cccaggtgta cacactgcct ccaagccaag aggaaatgac caagaaccag     1080

gtgtccctga cctgcctcgt gaagggattc tacccctccg atatcgccgt ggaatgggag     1140

agcaatggac agcccgagaa caactacaag acaacccctc ctgtgctgga cagcgacggc     1200

tcattcttcc tgtacagcag actgaccgtg gacaagagca gatggcaaga gggcaacgtg     1260

ttctcctgca gcgtgatgca cgaggccctg cacaaccact acacccagaa gtctctgtcc     1320

ctgtctctgg gcaagtga                                                   1338


<210>  16
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  GSͷ

<400>  16
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  17
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  GSͷ

<400>  17
Gly Gly Gly Gly Ser Gly Gly Gly Ser
1               5                   


<210>  18
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ǰ

<400>  18

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  19
<211>  453
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Avastin

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Pro His Tyr Tyr Gly Ser Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  20
<211>  214
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Avastin

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  21
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ABTAAɱ

<400>  21

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Asn Tyr Ser Gly Asn Thr Asp Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ser Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Gly Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Phe Glu Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  22
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ABTAAɱ

<400>  22

Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Tyr Pro Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  23
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ľͷ

<400>  23

Glu Ser Lys Tyr Gly Pro Pro Ser Pro Pro Ser Pro 
1               5                   10          


