                               SEQUENCE LISTING

<110> NEW YORK UNIVERSITY
 
<120> APPLICATION OF APOPTOSIS INHIBITOR 5 (API5) FOR EPITHELIAL 
      RESTITUTION

<130> 243735.000245

<140>
<141>

<150> 63/157,225
<151> 2021-03-05

<160> 79    

<170> PatentIn version 3.5

<210> 1
<211> 524
<212> PRT
<213> Homo sapiens

<400> 1
Met Pro Thr Val Glu Glu Leu Tyr Arg Asn Tyr Gly Ile Leu Ala Asp 
1               5                   10                  15      


Ala Thr Glu Gln Val Gly Gln His Lys Asp Ala Tyr Gln Val Ile Leu 
            20                  25                  30          


Asp Gly Val Lys Gly Gly Thr Lys Glu Lys Arg Leu Ala Ala Gln Phe 
        35                  40                  45              


Ile Pro Lys Phe Phe Lys His Phe Pro Glu Leu Ala Asp Ser Ala Ile 
    50                  55                  60                  


Asn Ala Gln Leu Asp Leu Cys Glu Asp Glu Asp Val Ser Ile Arg Arg 
65                  70                  75                  80  


Gln Ala Ile Lys Glu Leu Pro Gln Phe Ala Thr Gly Glu Asn Leu Pro 
                85                  90                  95      


Arg Val Ala Asp Ile Leu Thr Gln Leu Leu Gln Thr Asp Asp Ser Ala 
            100                 105                 110         


Glu Phe Asn Leu Val Asn Asn Ala Leu Leu Ser Ile Phe Lys Met Asp 
        115                 120                 125             


Ala Lys Gly Thr Leu Gly Gly Leu Phe Ser Gln Ile Leu Gln Gly Glu 
    130                 135                 140                 


Asp Ile Val Arg Glu Arg Ala Ile Lys Phe Leu Ser Thr Lys Leu Lys 
145                 150                 155                 160 


Thr Leu Pro Asp Glu Val Leu Thr Lys Glu Val Glu Glu Leu Ile Leu 
                165                 170                 175     


Thr Glu Ser Lys Lys Val Leu Glu Asp Val Thr Gly Glu Glu Phe Val 
            180                 185                 190         


Leu Phe Met Lys Ile Leu Ser Gly Leu Lys Ser Leu Gln Thr Val Ser 
        195                 200                 205             


Gly Arg Gln Gln Leu Val Glu Leu Val Ala Glu Gln Ala Asp Leu Glu 
    210                 215                 220                 


Gln Thr Phe Asn Pro Ser Asp Pro Asp Cys Val Asp Arg Leu Leu Gln 
225                 230                 235                 240 


Cys Thr Arg Gln Ala Val Pro Leu Phe Ser Lys Asn Val His Ser Thr 
                245                 250                 255     


Arg Phe Val Thr Tyr Phe Cys Glu Gln Val Leu Pro Asn Leu Gly Thr 
            260                 265                 270         


Leu Thr Thr Pro Val Glu Gly Leu Asp Ile Gln Leu Glu Val Leu Lys 
        275                 280                 285             


Leu Leu Ala Glu Met Ser Ser Phe Cys Gly Asp Met Glu Lys Leu Glu 
    290                 295                 300                 


Thr Asn Leu Arg Lys Leu Phe Asp Lys Leu Leu Glu Tyr Met Pro Leu 
305                 310                 315                 320 


Pro Pro Glu Glu Ala Glu Asn Gly Glu Asn Ala Gly Asn Glu Glu Pro 
                325                 330                 335     


Lys Leu Gln Phe Ser Tyr Val Glu Cys Leu Leu Tyr Ser Phe His Gln 
            340                 345                 350         


Leu Gly Arg Lys Leu Pro Asp Phe Leu Thr Ala Lys Leu Asn Ala Glu 
        355                 360                 365             


Lys Leu Lys Asp Phe Lys Ile Arg Leu Gln Tyr Phe Ala Arg Gly Leu 
    370                 375                 380                 


Gln Val Tyr Ile Arg Gln Leu Arg Leu Ala Leu Gln Gly Lys Thr Gly 
385                 390                 395                 400 


Glu Ala Leu Lys Thr Glu Glu Asn Lys Ile Lys Val Val Ala Leu Lys 
                405                 410                 415     


Ile Thr Asn Asn Ile Asn Val Leu Ile Lys Asp Leu Phe His Ile Pro 
            420                 425                 430         


Pro Ser Tyr Lys Ser Thr Val Thr Leu Ser Trp Lys Pro Val Gln Lys 
        435                 440                 445             


Val Glu Ile Gly Gln Lys Arg Ala Ser Glu Asp Thr Thr Ser Gly Ser 
    450                 455                 460                 


Pro Pro Lys Lys Ser Ser Ala Gly Pro Lys Arg Asp Ala Arg Gln Ile 
465                 470                 475                 480 


Tyr Asn Pro Pro Ser Gly Lys Tyr Ser Ser Asn Leu Gly Asn Phe Asn 
                485                 490                 495     


Tyr Glu Gln Arg Gly Ala Phe Arg Gly Ser Arg Gly Gly Arg Gly Trp 
            500                 505                 510         


Gly Thr Arg Gly Asn Arg Ser Arg Gly Arg Leu Tyr 
        515                 520                 


<210> 2
<211> 504
<212> PRT
<213> Mus musculus

<400> 2
Met Pro Thr Val Glu Glu Leu Tyr Arg Asn Tyr Gly Ile Leu Ala Asp 
1               5                   10                  15      


Ala Thr Glu Gln Val Gly Gln His Lys Asp Ala Tyr Gln Val Ile Leu 
            20                  25                  30          


Asp Gly Val Lys Gly Gly Thr Lys Glu Lys Arg Leu Ala Ala Gln Phe 
        35                  40                  45              


Ile Pro Lys Phe Phe Lys His Phe Pro Glu Leu Ala Asp Ser Ala Ile 
    50                  55                  60                  


Asn Ala Gln Leu Asp Leu Cys Glu Asp Glu Asp Val Ser Ile Arg Arg 
65                  70                  75                  80  


Gln Ala Ile Lys Glu Leu Pro Gln Phe Ala Thr Gly Glu Asn Leu Pro 
                85                  90                  95      


Arg Val Ala Asp Ile Leu Thr Gln Leu Leu Gln Thr Asp Asp Ser Ala 
            100                 105                 110         


Glu Phe Asn Leu Val Asn Asn Ala Leu Leu Ser Ile Phe Lys Met Asp 
        115                 120                 125             


Ala Lys Gly Thr Leu Gly Gly Leu Phe Ser Gln Ile Leu Gln Gly Glu 
    130                 135                 140                 


Asp Ile Val Arg Glu Arg Ala Ile Lys Phe Leu Ser Thr Lys Leu Lys 
145                 150                 155                 160 


Thr Leu Pro Asp Glu Val Leu Thr Lys Glu Val Glu Glu Leu Ile Leu 
                165                 170                 175     


Thr Glu Ser Lys Lys Val Leu Glu Asp Val Thr Gly Glu Glu Phe Val 
            180                 185                 190         


Leu Phe Met Lys Ile Leu Ser Gly Leu Lys Ser Leu Gln Thr Val Ser 
        195                 200                 205             


Gly Arg Gln Gln Leu Val Glu Leu Val Ala Glu Gln Ala Asp Leu Glu 
    210                 215                 220                 


Gln Ala Phe Ser Pro Ser Asp Pro Asp Cys Val Asp Arg Leu Leu Gln 
225                 230                 235                 240 


Cys Thr Arg Gln Ala Val Pro Leu Phe Ser Lys Asn Val His Ser Thr 
                245                 250                 255     


Arg Phe Val Thr Tyr Phe Cys Glu Gln Val Leu Pro Asn Leu Ser Thr 
            260                 265                 270         


Leu Thr Thr Pro Val Glu Gly Leu Asp Ile Gln Leu Glu Val Leu Lys 
        275                 280                 285             


Leu Leu Ala Glu Met Ser Ser Phe Cys Gly Asp Met Glu Lys Leu Glu 
    290                 295                 300                 


Thr Asn Leu Arg Lys Leu Phe Asp Lys Leu Leu Glu Tyr Met Pro Leu 
305                 310                 315                 320 


Pro Pro Glu Glu Ala Glu Asn Gly Glu Asn Ala Gly Asn Glu Glu Pro 
                325                 330                 335     


Lys Leu Gln Phe Ser Tyr Val Glu Cys Leu Leu Tyr Ser Phe His Gln 
            340                 345                 350         


Leu Gly Arg Lys Leu Pro Asp Phe Leu Thr Ala Lys Leu Asn Ala Glu 
        355                 360                 365             


Lys Leu Lys Asp Phe Lys Ile Arg Leu Gln Tyr Phe Ala Arg Gly Leu 
    370                 375                 380                 


Gln Val Tyr Ile Arg Gln Leu Arg Leu Ala Leu Gln Gly Lys Thr Gly 
385                 390                 395                 400 


Glu Ala Leu Lys Thr Glu Glu Asn Lys Ile Lys Val Val Ala Leu Lys 
                405                 410                 415     


Ile Thr Asn Asn Ile Asn Val Leu Ile Lys Asp Leu Phe His Ile Pro 
            420                 425                 430         


Pro Ser Tyr Lys Ser Thr Val Thr Leu Ser Trp Lys Pro Val Gln Lys 
        435                 440                 445             


Val Glu Ile Gly Gln Lys Arg Thr Ser Glu Asp Thr Ser Ser Gly Ser 
    450                 455                 460                 


Pro Pro Lys Lys Ser Pro Gly Gly Pro Lys Arg Asp Ala Arg Gln Ile 
465                 470                 475                 480 


Tyr Asn Pro Pro Ser Gly Lys Tyr Ser Ser Asn Leu Ser Asn Phe Asn 
                485                 490                 495     


Tyr Glu Arg Ser Leu Gln Gly Lys 
            500                 


<210> 3
<211> 481
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Met Lys His His His His His His Ser Ser Gly Leu Asn Asp Ile Phe 
1               5                   10                  15      


Glu Ala Gln Lys Ile Glu Trp His Glu Glu Asn Leu Tyr Phe Gln Gly 
            20                  25                  30          


Ser Met Pro Thr Val Glu Glu Leu Tyr Arg Asn Tyr Gly Ile Leu Ala 
        35                  40                  45              


Asp Ala Thr Glu Gln Val Gly Gln His Lys Asp Ala Tyr Gln Val Ile 
    50                  55                  60                  


Leu Asp Gly Val Lys Gly Gly Thr Lys Glu Lys Arg Leu Ala Ala Gln 
65                  70                  75                  80  


Phe Ile Pro Lys Phe Phe Lys His Phe Pro Glu Leu Ala Asp Ser Ala 
                85                  90                  95      


Ile Asn Ala Gln Leu Asp Leu Cys Glu Asp Glu Asp Val Ser Ile Arg 
            100                 105                 110         


Arg Gln Ala Ile Lys Glu Leu Pro Gln Phe Ala Thr Gly Glu Asn Leu 
        115                 120                 125             


Pro Arg Val Ala Asp Ile Leu Thr Gln Leu Leu Gln Thr Asp Asp Ser 
    130                 135                 140                 


Ala Glu Phe Asn Leu Val Asn Asn Ala Leu Leu Ser Ile Phe Lys Met 
145                 150                 155                 160 


Asp Ala Lys Gly Thr Leu Gly Gly Leu Phe Ser Gln Ile Leu Gln Gly 
                165                 170                 175     


Glu Asp Ile Val Arg Glu Arg Ala Ile Lys Phe Leu Ser Thr Lys Leu 
            180                 185                 190         


Lys Thr Leu Pro Asp Glu Val Leu Thr Lys Glu Val Glu Glu Leu Ile 
        195                 200                 205             


Leu Thr Glu Ser Lys Lys Val Leu Glu Asp Val Thr Gly Glu Glu Phe 
    210                 215                 220                 


Val Leu Phe Met Lys Ile Leu Ser Gly Leu Lys Ser Leu Gln Thr Val 
225                 230                 235                 240 


Ser Gly Arg Gln Gln Leu Val Glu Leu Val Ala Glu Gln Ala Asp Leu 
                245                 250                 255     


Glu Gln Thr Phe Asn Pro Ser Asp Pro Asp Cys Val Asp Arg Leu Leu 
            260                 265                 270         


Gln Cys Thr Arg Gln Ala Val Pro Leu Phe Ser Lys Asn Val His Ser 
        275                 280                 285             


Thr Arg Phe Val Thr Tyr Phe Cys Glu Gln Val Leu Pro Asn Leu Gly 
    290                 295                 300                 


Thr Leu Thr Thr Pro Val Glu Gly Leu Asp Ile Gln Leu Glu Val Leu 
305                 310                 315                 320 


Lys Leu Leu Ala Glu Met Ser Ser Phe Cys Gly Asp Met Glu Lys Leu 
                325                 330                 335     


Glu Thr Asn Leu Arg Lys Leu Phe Asp Lys Leu Leu Glu Tyr Met Pro 
            340                 345                 350         


Leu Pro Pro Glu Glu Ala Glu Asn Gly Glu Asn Ala Gly Asn Glu Glu 
        355                 360                 365             


Pro Lys Leu Gln Phe Ser Tyr Val Glu Cys Leu Leu Tyr Ser Phe His 
    370                 375                 380                 


Gln Leu Gly Arg Lys Leu Pro Asp Phe Leu Thr Ala Lys Leu Asn Ala 
385                 390                 395                 400 


Glu Lys Leu Lys Asp Phe Lys Ile Arg Leu Gln Tyr Phe Ala Arg Gly 
                405                 410                 415     


Leu Gln Val Tyr Ile Arg Gln Leu Arg Leu Ala Leu Gln Gly Lys Thr 
            420                 425                 430         


Gly Glu Ala Leu Lys Thr Glu Glu Asn Lys Ile Lys Val Val Ala Leu 
        435                 440                 445             


Lys Ile Thr Asn Asn Ile Asn Val Leu Ile Lys Asp Leu Phe His Ile 
    450                 455                 460                 


Pro Pro Ser Tyr Lys Ser Thr Val Thr Leu Ser Trp Lys Pro Val Gln 
465                 470                 475                 480 


Lys 
    


<210> 4
<211> 481
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Met Lys His His His His His His Ser Ser Gly Leu Asn Asp Ile Phe 
1               5                   10                  15      


Glu Ala Gln Lys Ile Glu Trp His Glu Glu Asn Leu Tyr Phe Gln Gly 
            20                  25                  30          


Ser Met Pro Thr Val Glu Glu Leu Lys Arg Asn Lys Gly Ile Leu Ala 
        35                  40                  45              


Asp Ala Thr Glu Gln Val Gly Gln His Lys Asp Ala Tyr Gln Val Ile 
    50                  55                  60                  


Leu Asp Gly Val Lys Gly Gly Thr Lys Glu Lys Arg Leu Ala Ala Gln 
65                  70                  75                  80  


Phe Ile Pro Lys Phe Phe Lys His Phe Pro Glu Leu Ala Asp Ser Ala 
                85                  90                  95      


Ile Asn Ala Gln Leu Asp Leu Cys Glu Asp Glu Asp Val Ser Ile Arg 
            100                 105                 110         


Arg Gln Ala Ile Lys Glu Leu Pro Gln Phe Ala Thr Gly Glu Asn Leu 
        115                 120                 125             


Pro Arg Val Ala Asp Ile Leu Thr Gln Leu Leu Gln Thr Asp Asp Ser 
    130                 135                 140                 


Ala Glu Phe Asn Leu Val Asn Asn Ala Leu Leu Ser Ile Phe Lys Met 
145                 150                 155                 160 


Asp Ala Lys Gly Thr Leu Gly Gly Leu Phe Ser Gln Ile Leu Gln Gly 
                165                 170                 175     


Glu Asp Ile Val Arg Glu Arg Ala Ile Lys Phe Leu Ser Thr Lys Leu 
            180                 185                 190         


Lys Thr Leu Pro Asp Glu Val Leu Thr Lys Glu Val Glu Glu Leu Ile 
        195                 200                 205             


Leu Thr Glu Ser Lys Lys Val Leu Glu Asp Val Thr Gly Glu Glu Phe 
    210                 215                 220                 


Val Leu Phe Met Lys Ile Leu Ser Gly Leu Lys Ser Leu Gln Thr Val 
225                 230                 235                 240 


Ser Gly Arg Gln Gln Leu Val Glu Leu Val Ala Glu Gln Ala Asp Leu 
                245                 250                 255     


Glu Gln Thr Phe Asn Pro Ser Asp Pro Asp Cys Val Asp Arg Leu Leu 
            260                 265                 270         


Gln Cys Thr Arg Gln Ala Val Pro Leu Phe Ser Lys Asn Val His Ser 
        275                 280                 285             


Thr Arg Phe Val Thr Tyr Phe Cys Glu Gln Val Leu Pro Asn Leu Gly 
    290                 295                 300                 


Thr Leu Thr Thr Pro Val Glu Gly Leu Asp Ile Gln Leu Glu Val Leu 
305                 310                 315                 320 


Lys Leu Leu Ala Glu Met Ser Ser Phe Cys Gly Asp Met Glu Lys Leu 
                325                 330                 335     


Glu Thr Asn Leu Arg Lys Leu Phe Asp Lys Leu Leu Glu Tyr Met Pro 
            340                 345                 350         


Leu Pro Pro Glu Glu Ala Glu Asn Gly Glu Asn Ala Gly Asn Glu Glu 
        355                 360                 365             


Pro Lys Leu Gln Phe Ser Tyr Val Glu Cys Leu Leu Tyr Ser Phe His 
    370                 375                 380                 


Gln Leu Gly Arg Lys Leu Pro Asp Phe Leu Thr Ala Lys Leu Asn Ala 
385                 390                 395                 400 


Glu Lys Leu Lys Asp Phe Lys Ile Arg Leu Gln Tyr Phe Ala Arg Gly 
                405                 410                 415     


Leu Gln Val Tyr Ile Arg Gln Leu Arg Leu Ala Leu Gln Gly Lys Thr 
            420                 425                 430         


Gly Glu Ala Leu Lys Thr Glu Glu Asn Lys Ile Lys Val Val Ala Leu 
        435                 440                 445             


Lys Ile Thr Asn Asn Ile Asn Val Leu Ile Lys Asp Leu Phe His Ile 
    450                 455                 460                 


Pro Pro Ser Tyr Lys Ser Thr Val Thr Leu Ser Trp Lys Pro Val Gln 
465                 470                 475                 480 


Lys 
    


<210> 5
<211> 481
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Met Lys His His His His His His Ser Ser Gly Leu Asn Asp Ile Phe 
1               5                   10                  15      


Glu Ala Gln Lys Ile Glu Trp His Glu Glu Asn Leu Tyr Phe Gln Gly 
            20                  25                  30          


Ser Met Pro Thr Val Glu Glu Leu Tyr Arg Asn Tyr Gly Ile Leu Ala 
        35                  40                  45              


Asp Ala Thr Glu Gln Val Gly Gln His Lys Asp Ala Tyr Gln Val Ile 
    50                  55                  60                  


Leu Asp Gly Val Lys Gly Gly Thr Lys Glu Lys Arg Leu Ala Ala Gln 
65                  70                  75                  80  


Phe Ile Pro Lys Phe Phe Lys His Phe Pro Glu Leu Ala Asp Ser Ala 
                85                  90                  95      


Ile Asn Ala Gln Leu Asp Leu Cys Glu Asp Glu Asp Val Ser Ile Arg 
            100                 105                 110         


Arg Gln Ala Ile Lys Glu Leu Pro Gln Phe Ala Thr Gly Glu Asn Leu 
        115                 120                 125             


Pro Arg Val Ala Asp Ile Leu Thr Gln Leu Leu Gln Thr Asp Asp Ser 
    130                 135                 140                 


Ala Glu Phe Asn Leu Val Asn Asn Ala Leu Leu Ser Ile Phe Lys Met 
145                 150                 155                 160 


Asp Ala Lys Gly Thr Leu Gly Gly Leu Phe Ser Gln Ile Leu Gln Gly 
                165                 170                 175     


Glu Asp Ile Val Arg Glu Arg Ala Ile Lys Phe Leu Ser Thr Lys Leu 
            180                 185                 190         


Lys Thr Leu Pro Asp Glu Val Leu Thr Lys Glu Val Glu Glu Leu Ile 
        195                 200                 205             


Leu Thr Glu Ser Lys Lys Val Leu Lys Lys Val Thr Gly Glu Glu Phe 
    210                 215                 220                 


Val Leu Phe Met Lys Ile Leu Ser Gly Leu Lys Ser Leu Gln Thr Val 
225                 230                 235                 240 


Ser Gly Arg Gln Gln Leu Val Glu Leu Val Ala Glu Gln Ala Asp Leu 
                245                 250                 255     


Glu Gln Thr Phe Asn Pro Ser Asp Pro Asp Cys Val Asp Arg Leu Leu 
            260                 265                 270         


Gln Cys Thr Arg Gln Ala Val Pro Leu Phe Ser Lys Asn Val His Ser 
        275                 280                 285             


Thr Arg Phe Val Thr Tyr Phe Cys Glu Gln Val Leu Pro Asn Leu Gly 
    290                 295                 300                 


Thr Leu Thr Thr Pro Val Glu Gly Leu Asp Ile Gln Leu Glu Val Leu 
305                 310                 315                 320 


Lys Leu Leu Ala Glu Met Ser Ser Phe Cys Gly Asp Met Glu Lys Leu 
                325                 330                 335     


Glu Thr Asn Leu Arg Lys Leu Phe Asp Lys Leu Leu Glu Tyr Met Pro 
            340                 345                 350         


Leu Pro Pro Glu Glu Ala Glu Asn Gly Glu Asn Ala Gly Asn Glu Glu 
        355                 360                 365             


Pro Lys Leu Gln Phe Ser Tyr Val Glu Cys Leu Leu Tyr Ser Phe His 
    370                 375                 380                 


Gln Leu Gly Arg Lys Leu Pro Asp Phe Leu Thr Ala Lys Leu Asn Ala 
385                 390                 395                 400 


Glu Lys Leu Lys Asp Phe Lys Ile Arg Leu Gln Tyr Phe Ala Arg Gly 
                405                 410                 415     


Leu Gln Val Tyr Ile Arg Gln Leu Arg Leu Ala Leu Gln Gly Lys Thr 
            420                 425                 430         


Gly Glu Ala Leu Lys Thr Glu Glu Asn Lys Ile Lys Val Val Ala Leu 
        435                 440                 445             


Lys Ile Thr Asn Asn Ile Asn Val Leu Ile Lys Asp Leu Phe His Ile 
    450                 455                 460                 


Pro Pro Ser Tyr Lys Ser Thr Val Thr Leu Ser Trp Lys Pro Val Gln 
465                 470                 475                 480 


Lys 
    


<210> 6
<211> 239
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Met Lys His His His His His His Ser Ser Gly Leu Asn Asp Ile Phe 
1               5                   10                  15      


Glu Ala Gln Lys Ile Glu Trp His Glu Glu Asn Leu Tyr Phe Gln Gly 
            20                  25                  30          


Ser Met Pro Thr Val Glu Glu Leu Tyr Arg Asn Tyr Gly Ile Leu Ala 
        35                  40                  45              


Asp Ala Thr Glu Gln Val Gly Gln His Lys Asp Ala Tyr Gln Val Ile 
    50                  55                  60                  


Leu Asp Gly Val Lys Gly Gly Thr Lys Glu Lys Arg Leu Ala Ala Gln 
65                  70                  75                  80  


Phe Ile Pro Lys Phe Phe Lys His Phe Pro Glu Leu Ala Asp Ser Ala 
                85                  90                  95      


Ile Asn Ala Gln Leu Asp Leu Cys Glu Asp Glu Asp Val Ser Ile Arg 
            100                 105                 110         


Arg Gln Ala Ile Lys Glu Leu Pro Gln Phe Ala Thr Gly Glu Asn Leu 
        115                 120                 125             


Pro Arg Val Ala Asp Ile Leu Thr Gln Leu Leu Gln Thr Asp Asp Ser 
    130                 135                 140                 


Ala Glu Phe Asn Leu Val Asn Asn Ala Leu Leu Ser Ile Phe Lys Met 
145                 150                 155                 160 


Asp Ala Lys Gly Thr Leu Gly Gly Leu Phe Ser Gln Ile Leu Gln Gly 
                165                 170                 175     


Glu Asp Ile Val Arg Glu Arg Ala Ile Lys Phe Leu Ser Thr Lys Leu 
            180                 185                 190         


Lys Thr Leu Pro Asp Glu Val Leu Thr Lys Glu Val Glu Glu Leu Ile 
        195                 200                 205             


Leu Thr Glu Ser Lys Lys Val Leu Glu Asp Val Thr Gly Glu Glu Phe 
    210                 215                 220                 


Val Leu Phe Met Lys Ile Leu Ser Gly Leu Lys Ser Leu Gln Thr 
225                 230                 235                 


<210> 7
<211> 448
<212> PRT
<213> Homo sapiens

<400> 7
Met Pro Thr Val Glu Glu Leu Tyr Arg Asn Tyr Gly Ile Leu Ala Asp 
1               5                   10                  15      


Ala Thr Glu Gln Val Gly Gln His Lys Asp Ala Tyr Gln Val Ile Leu 
            20                  25                  30          


Asp Gly Val Lys Gly Gly Thr Lys Glu Lys Arg Leu Ala Ala Gln Phe 
        35                  40                  45              


Ile Pro Lys Phe Phe Lys His Phe Pro Glu Leu Ala Asp Ser Ala Ile 
    50                  55                  60                  


Asn Ala Gln Leu Asp Leu Cys Glu Asp Glu Asp Val Ser Ile Arg Arg 
65                  70                  75                  80  


Gln Ala Ile Lys Glu Leu Pro Gln Phe Ala Thr Gly Glu Asn Leu Pro 
                85                  90                  95      


Arg Val Ala Asp Ile Leu Thr Gln Leu Leu Gln Thr Asp Asp Ser Ala 
            100                 105                 110         


Glu Phe Asn Leu Val Asn Asn Ala Leu Leu Ser Ile Phe Lys Met Asp 
        115                 120                 125             


Ala Lys Gly Thr Leu Gly Gly Leu Phe Ser Gln Ile Leu Gln Gly Glu 
    130                 135                 140                 


Asp Ile Val Arg Glu Arg Ala Ile Lys Phe Leu Ser Thr Lys Leu Lys 
145                 150                 155                 160 


Thr Leu Pro Asp Glu Val Leu Thr Lys Glu Val Glu Glu Leu Ile Leu 
                165                 170                 175     


Thr Glu Ser Lys Lys Val Leu Glu Asp Val Thr Gly Glu Glu Phe Val 
            180                 185                 190         


Leu Phe Met Lys Ile Leu Ser Gly Leu Lys Ser Leu Gln Thr Val Ser 
        195                 200                 205             


Gly Arg Gln Gln Leu Val Glu Leu Val Ala Glu Gln Ala Asp Leu Glu 
    210                 215                 220                 


Gln Thr Phe Asn Pro Ser Asp Pro Asp Cys Val Asp Arg Leu Leu Gln 
225                 230                 235                 240 


Cys Thr Arg Gln Ala Val Pro Leu Phe Ser Lys Asn Val His Ser Thr 
                245                 250                 255     


Arg Phe Val Thr Tyr Phe Cys Glu Gln Val Leu Pro Asn Leu Gly Thr 
            260                 265                 270         


Leu Thr Thr Pro Val Glu Gly Leu Asp Ile Gln Leu Glu Val Leu Lys 
        275                 280                 285             


Leu Leu Ala Glu Met Ser Ser Phe Cys Gly Asp Met Glu Lys Leu Glu 
    290                 295                 300                 


Thr Asn Leu Arg Lys Leu Phe Asp Lys Leu Leu Glu Tyr Met Pro Leu 
305                 310                 315                 320 


Pro Pro Glu Glu Ala Glu Asn Gly Glu Asn Ala Gly Asn Glu Glu Pro 
                325                 330                 335     


Lys Leu Gln Phe Ser Tyr Val Glu Cys Leu Leu Tyr Ser Phe His Gln 
            340                 345                 350         


Leu Gly Arg Lys Leu Pro Asp Phe Leu Thr Ala Lys Leu Asn Ala Glu 
        355                 360                 365             


Lys Leu Lys Asp Phe Lys Ile Arg Leu Gln Tyr Phe Ala Arg Gly Leu 
    370                 375                 380                 


Gln Val Tyr Ile Arg Gln Leu Arg Leu Ala Leu Gln Gly Lys Thr Gly 
385                 390                 395                 400 


Glu Ala Leu Lys Thr Glu Glu Asn Lys Ile Lys Val Val Ala Leu Lys 
                405                 410                 415     


Ile Thr Asn Asn Ile Asn Val Leu Ile Lys Asp Leu Phe His Ile Pro 
            420                 425                 430         


Pro Ser Tyr Lys Ser Thr Val Thr Leu Ser Trp Lys Pro Val Gln Lys 
        435                 440                 445             


<210> 8
<211> 206
<212> PRT
<213> Homo sapiens

<400> 8
Met Pro Thr Val Glu Glu Leu Tyr Arg Asn Tyr Gly Ile Leu Ala Asp 
1               5                   10                  15      


Ala Thr Glu Gln Val Gly Gln His Lys Asp Ala Tyr Gln Val Ile Leu 
            20                  25                  30          


Asp Gly Val Lys Gly Gly Thr Lys Glu Lys Arg Leu Ala Ala Gln Phe 
        35                  40                  45              


Ile Pro Lys Phe Phe Lys His Phe Pro Glu Leu Ala Asp Ser Ala Ile 
    50                  55                  60                  


Asn Ala Gln Leu Asp Leu Cys Glu Asp Glu Asp Val Ser Ile Arg Arg 
65                  70                  75                  80  


Gln Ala Ile Lys Glu Leu Pro Gln Phe Ala Thr Gly Glu Asn Leu Pro 
                85                  90                  95      


Arg Val Ala Asp Ile Leu Thr Gln Leu Leu Gln Thr Asp Asp Ser Ala 
            100                 105                 110         


Glu Phe Asn Leu Val Asn Asn Ala Leu Leu Ser Ile Phe Lys Met Asp 
        115                 120                 125             


Ala Lys Gly Thr Leu Gly Gly Leu Phe Ser Gln Ile Leu Gln Gly Glu 
    130                 135                 140                 


Asp Ile Val Arg Glu Arg Ala Ile Lys Phe Leu Ser Thr Lys Leu Lys 
145                 150                 155                 160 


Thr Leu Pro Asp Glu Val Leu Thr Lys Glu Val Glu Glu Leu Ile Leu 
                165                 170                 175     


Thr Glu Ser Lys Lys Val Leu Glu Asp Val Thr Gly Glu Glu Phe Val 
            180                 185                 190         


Leu Phe Met Lys Ile Leu Ser Gly Leu Lys Ser Leu Gln Thr 
        195                 200                 205     


<210> 9
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Met Lys His His His His His His Ser Ser Gly Leu Asn Asp Ile Phe 
1               5                   10                  15      


Glu Ala Gln Lys Ile Glu Trp His Glu 
            20                  25  


<210> 10
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Glu Asn Leu Tyr Phe Gln Gly Ser 
1               5               


<210> 11
<211> 481
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Met Lys His His His His His His Ser Ser Gly Leu Asn Asp Ile Phe 
1               5                   10                  15      


Glu Ala Gln Lys Ile Glu Trp His Glu Glu Asn Leu Tyr Phe Gln Gly 
            20                  25                  30          


Ser Met Pro Thr Val Glu Glu Leu Lys Arg Asn Lys Gly Ile Leu Ala 
        35                  40                  45              


Asp Ala Thr Glu Gln Val Gly Gln His Lys Asp Ala Tyr Gln Val Ile 
    50                  55                  60                  


Leu Asp Gly Val Lys Gly Gly Thr Lys Glu Lys Arg Leu Ala Ala Gln 
65                  70                  75                  80  


Phe Ile Pro Lys Phe Phe Lys His Phe Pro Glu Leu Ala Asp Ser Ala 
                85                  90                  95      


Ile Asn Ala Gln Leu Asp Leu Cys Glu Asp Glu Asp Val Ser Ile Arg 
            100                 105                 110         


Arg Gln Ala Ile Lys Glu Leu Pro Gln Phe Ala Thr Gly Glu Asn Leu 
        115                 120                 125             


Pro Arg Val Ala Asp Ile Leu Thr Gln Leu Leu Gln Thr Asp Asp Ser 
    130                 135                 140                 


Ala Glu Phe Asn Leu Val Asn Asn Ala Leu Leu Ser Ile Phe Lys Met 
145                 150                 155                 160 


Asp Ala Lys Gly Thr Leu Gly Gly Leu Phe Ser Gln Ile Leu Gln Gly 
                165                 170                 175     


Glu Asp Ile Val Arg Glu Arg Ala Ile Lys Phe Leu Ser Thr Lys Leu 
            180                 185                 190         


Lys Thr Leu Pro Asp Glu Val Leu Thr Lys Glu Val Glu Glu Leu Ile 
        195                 200                 205             


Leu Thr Glu Ser Lys Lys Val Leu Lys Lys Val Thr Gly Glu Glu Phe 
    210                 215                 220                 


Val Leu Phe Met Lys Ile Leu Ser Gly Leu Lys Ser Leu Gln Thr Val 
225                 230                 235                 240 


Ser Gly Arg Gln Gln Leu Val Glu Leu Val Ala Glu Gln Ala Asp Leu 
                245                 250                 255     


Glu Gln Thr Phe Asn Pro Ser Asp Pro Asp Cys Val Asp Arg Leu Leu 
            260                 265                 270         


Gln Cys Thr Arg Gln Ala Val Pro Leu Phe Ser Lys Asn Val His Ser 
        275                 280                 285             


Thr Arg Phe Val Thr Tyr Phe Cys Glu Gln Val Leu Pro Asn Leu Gly 
    290                 295                 300                 


Thr Leu Thr Thr Pro Val Glu Gly Leu Asp Ile Gln Leu Glu Val Leu 
305                 310                 315                 320 


Lys Leu Leu Ala Glu Met Ser Ser Phe Cys Gly Asp Met Glu Lys Leu 
                325                 330                 335     


Glu Thr Asn Leu Arg Lys Leu Phe Asp Lys Leu Leu Glu Tyr Met Pro 
            340                 345                 350         


Leu Pro Pro Glu Glu Ala Glu Asn Gly Glu Asn Ala Gly Asn Glu Glu 
        355                 360                 365             


Pro Lys Leu Gln Phe Ser Tyr Val Glu Cys Leu Leu Tyr Ser Phe His 
    370                 375                 380                 


Gln Leu Gly Arg Lys Leu Pro Asp Phe Leu Thr Ala Lys Leu Asn Ala 
385                 390                 395                 400 


Glu Lys Leu Lys Asp Phe Lys Ile Arg Leu Gln Tyr Phe Ala Arg Gly 
                405                 410                 415     


Leu Gln Val Tyr Ile Arg Gln Leu Arg Leu Ala Leu Gln Gly Lys Thr 
            420                 425                 430         


Gly Glu Ala Leu Lys Thr Glu Glu Asn Lys Ile Lys Val Val Ala Leu 
        435                 440                 445             


Lys Ile Thr Asn Asn Ile Asn Val Leu Ile Lys Asp Leu Phe His Ile 
    450                 455                 460                 


Pro Pro Ser Tyr Lys Ser Thr Val Thr Leu Ser Trp Lys Pro Val Gln 
465                 470                 475                 480 


Lys 
    


<210> 12
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10      


<210> 13
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu 
1               5                   10                  15      


Asp Asp 
        


<210> 14
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Gln Arg Leu Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Glu Asp Asp Phe 
            20  


<210> 15
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Gln Gly Leu Ile Gly Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Asp Ser Val Lys 
            20      


<210> 16
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Gly Glu Trp Trp Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Glu Glu Glu Asp 
            20  


<210> 17
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Gln Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Glu Asp Asp Phe 
            20  


<210> 18
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu 
1               5                   10                  15      


Asp 
    


<210> 19
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu 
1               5                   10                  15      


<210> 20
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15  


<210> 21
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu Asp 
1               5                   10                  15      


<210> 22
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Glu Val Arg Ser Phe Cys Thr Asp Trp Pro Ala Glu Lys Ser Cys Lys 
1               5                   10                  15      


Pro Leu Arg Gly 
            20  


<210> 23
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Arg Ala Pro Glu Ser Phe Val Cys Tyr Trp Glu Thr Ile Cys Phe Glu 
1               5                   10                  15      


Arg Ser Glu Gln 
            20  


<210> 24
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Glu Met Cys Tyr Phe Pro Gly Ile Cys Trp Met 
1               5                   10      


<210> 25
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Gly Glu Asn Trp Cys Asp Ser Thr Leu Met Ala Tyr Asp Leu Cys Gly 
1               5                   10                  15      


Gln Val Asn Met 
            20  


<210> 26
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 26
Met Asp Glu Leu Ala Phe Tyr Cys Gly Ile Trp Glu Cys Leu Met His 
1               5                   10                  15      


Gln Glu Gln Lys 
            20  


<210> 27
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Asp Leu Cys Asp Val Asp Phe Cys Trp Phe 
1               5                   10  


<210> 28
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 28
Lys Ser Cys Ser Glu Leu His Trp Leu Leu Val Glu Glu Cys Leu Phe 
1               5                   10                  15      


<210> 29
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 29
Arg Asn Glu Asp Pro Cys Val Val Leu Leu Glu Met Gly Leu Glu Cys 
1               5                   10                  15      


Trp Glu Gly Val 
            20  


<210> 30
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Asp Thr Cys Val Asp Leu Val Arg Leu Gly Leu Glu Cys Trp Gly 
1               5                   10                  15  


<210> 31
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 31
Gln Arg Gln Met Val Asp Phe Cys Leu Pro Gln Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Asp Gly Phe 
            20  


<210> 32
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 32
Asp Leu Cys Leu Arg Asp Trp Gly Cys Leu Trp 
1               5                   10      


<210> 33
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 33
Gln Arg Gln Met Val Asp Phe Cys Leu Pro Gln Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Asp Gly Phe 
            20  


<210> 34
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 34
Gln Arg His Pro Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Asp Asp Asp 
            20  


<210> 35
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 35
Asn Arg Gln Met Glu Asp Ile Cys Leu Pro Gln Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Asp Asp Phe 
            20  


<210> 36
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 36
Gln Arg Leu Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Asp Arg Phe 
            20  


<210> 37
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 37
Gln Trp His Met Glu Asp Ile Cys Leu Pro Gln Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Asp Val Leu 
            20  


<210> 38
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 38
Gln Trp Gln Met Glu Asn Val Cys Leu Pro Lys Trp Gly Cys Leu Trp 
1               5                   10                  15      


Glu Glu Leu Asp 
            20  


<210> 39
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 39
Leu Trp Ala Met Glu Asp Ile Cys Leu Pro Lys Trp Gly Cys Leu Trp 
1               5                   10                  15      


Glu Asp Asp Phe 
            20  


<210> 40
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 40
Leu Arg Leu Met Asp Asn Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Asp Asp Gly Phe 
            20  


<210> 41
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 41
His Ser Gln Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Asp Glu Leu 
            20  


<210> 42
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 42
Gln Trp Gln Val Met Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Ala Asp Glu Tyr 
            20  


<210> 43
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 43
Gln Gly Leu Ile Gly Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Asp Ser Val 
            20  


<210> 44
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 44
His Arg Leu Val Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Asn Asp Phe 
            20  


<210> 45
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 45
Gln Met His Met Met Asp Ile Cys Leu Pro Lys Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Asp Thr Ser 
            20  


<210> 46
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 46
Leu Arg Ile Phe Glu Asp Ile Cys Leu Pro Lys Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Glu Gly Phe 
            20  


<210> 47
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 47
Gln Ser Tyr Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Ser 
1               5                   10                  15      


Asp Asp Ala Ser 
            20  


<210> 48
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 48
Gln Gly Asp Phe Trp Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Ser 
1               5                   10                  15      


Gly Glu Gly Tyr 
            20  


<210> 49
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 49
Arg Trp Gln Thr Glu Asp Val Cys Leu Pro Lys Trp Gly Cys Leu Phe 
1               5                   10                  15      


Gly Asp Gly Val 
            20  


<210> 50
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 50
Gln Gly Leu Ile Gly Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Asp Ser Val 
            20  


<210> 51
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 51
Leu Ile Phe Met Glu Asp Val Cys Leu Pro Gln Trp Gly Cys Leu Trp 
1               5                   10                  15      


Glu Asp Gly Val 
            20  


<210> 52
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 52
Gln Arg Asp Met Gly Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Glu Asp Gly Val 
            20  


<210> 53
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 53
Gln Arg His Met Met Asp Phe Cys Leu Pro Lys Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Asp Gly Tyr 
            20  


<210> 54
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 54
Gln Arg Pro Ile Met Asp Phe Cys Leu Pro Lys Trp Gly Cys Leu Trp 
1               5                   10                  15      


Glu Asp Gly Phe 
            20  


<210> 55
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 55
Glu Arg Gln Met Val Asp Phe Cys Leu Pro Lys Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Asp Gly Phe 
            20  


<210> 56
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 56
Gln Gly Tyr Met Val Asp Phe Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Asp Ala Asn 
            20  


<210> 57
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 57
Lys Met Gly Arg Val Asp Phe Cys Leu Pro Lys Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Asp Glu Leu 
            20  


<210> 58
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 58
Gln Ser Gln Leu Glu Asp Phe Cys Leu Pro Lys Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Asp Gly Phe 
            20  


<210> 59
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 59
Gln Gly Gly Met Gly Asp Phe Cys Leu Pro Gln Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Glu Asp Leu 
            20  


<210> 60
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 60
Gln Arg Leu Met Trp Glu Ile Cys Leu Pro Leu Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Asp Gly Leu 
            20  


<210> 61
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 61
Gln Arg Gln Ile Met Asp Phe Cys Leu Pro His Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Asp Gly Phe 
            20  


<210> 62
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 62
Gly Arg Gln Val Val Asp Phe Cys Leu Pro Lys Trp Gly Cys Leu Trp 
1               5                   10                  15      


Glu Glu Gly Leu 
            20  


<210> 63
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 63
Gln Met Gln Met Ser Asp Phe Cys Leu Pro Gln Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Asp Gly Tyr 
            20  


<210> 64
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 64
Lys Ser Arg Met Gly Asp Phe Cys Leu Pro Glu Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Asp Glu Leu 
            20  


<210> 65
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 65
Glu Arg Gln Met Glu Asp Phe Cys Leu Pro Gln Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Asp Gly Val 
            20  


<210> 66
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 66
Gln Arg Gln Val Val Asp Phe Cys Leu Pro Gln Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Asp Gly Ser 
            20  


<210> 67
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 67
Trp Trp Glu Gln Asp Arg Asp Trp Asp Phe Asp Val Phe Gly Gly Gly 
1               5                   10                  15      


Thr Pro 
        


<210> 68
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 68
Glu Tyr Glu Lys Glu Tyr Glu 
1               5           


<210> 69
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 69
Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu 
1               5                   10                  15      


Asp Asp 
        


<210> 70
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Variable lysine

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Variable lysine

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Variable lysine

<400> 70
Ala Lys Lys Pro Gly Lys Ala Lys Pro Gly 
1               5                   10  


<210> 71
<211> 232
<212> PRT
<213> Homo sapiens

<400> 71
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Glu Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210> 72
<211> 232
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 72
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210> 73
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 73
Gly Ser Gly Glu Gly Glu Gly Ser Glu Gly Ser Gly 
1               5                   10          


<210> 74
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 74
Gly Gly Ser Glu Gly Glu Gly Ser Glu Gly Gly Ser 
1               5                   10          


<210> 75
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 75
Gly Gly Gly Gly Ser 
1               5   


<210> 76
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 76
Met Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr 
1               5                   10                  15      


Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg 
            20                  25                  30          


Tyr Tyr Arg Ile Thr Tyr Gly Arg Glu Val Gln Lys Tyr Ser Asp Leu 
        35                  40                  45              


Gly Pro Leu Tyr Ile Tyr Gln Glu Phe Thr Val Pro Gly Ser Lys Ser 
    50                  55                  60                  


Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr 
65                  70                  75                  80  


Val Tyr Ala Val Thr Gly Ser Gly Glu Ser Pro Ala Ser Ser Lys Pro 
                85                  90                  95      


Ile Ser Ile Asn Tyr Arg Thr Glu Ile Asp Lys 
            100                 105         


<210> 77
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 77
Met Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr 
1               5                   10                  15      


Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg 
            20                  25                  30          


Tyr Tyr Arg Ile Thr Tyr Gly Arg Glu Val Gln Lys Tyr Ser Asp Trp 
        35                  40                  45              


Gly Pro Leu Tyr Ile Tyr Asn Glu Phe Thr Val Pro Gly Ser Lys Ser 
    50                  55                  60                  


Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr 
65                  70                  75                  80  


Val Tyr Ala Val Thr Gly Ser Gly Glu Ser Pro Ala Ser Ser Lys Pro 
                85                  90                  95      


Ile Ser Ile Asn Tyr Arg Thr Glu Ile Asp Lys 
            100                 105         


<210> 78
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 78
His His His His His His 
1               5       


<210> 79
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 79
Gly Gly Gly Ser 
1               


