                         SEQUENCE LISTING

<110>  THE CHILDREN'S MEDICAL CENTER CORPORATION
 
<120>  STROMA-FREE NK CELL DIFFERENTIATION FROM HUMAN PLURIPOTENT STEM 
       CELLS

<130>  701039-097920WOPT

<150>  63/157,112
<151>  2021-03-05

<160>  53    

<170>  PatentIn version 3.5

<210>  1
<211>  8873
<212>  DNA
<213>  Homo sapiens

<400>  1
actgaccatt tggcgatcca ttgagaggag ggtttggaaa agtggctcct ttgtgacagc       60

tctcgccaga ttggggggct gctgatttgc atctcattag ccatgcgggc ggccggctga      120

atataagggc ggcaggcgcc ggcgagagcc agatcctctg cgcgcacccg cggagacccg      180

acccggccga gggcagagcg caggggaacc cgggcagccg cggcgcagag cctcctccca      240

cggcccggcc cctccggtcc tgcgcgtgtg tactggatgg cattggctgg attcatcgga      300

aagacgcgga tctttgctgt gacaccggag atcggagccc ggagtgctcc cggaacgacc      360

gccgccgccg agtgacaccg ggccgcgatc cgcaggggcc gccgcgcaca cccgccgccg      420

ccgaccgtcc cctcagcgcg cgccgctggc cccggattat cgccttgccc gtgggatttc      480

cagaccgcgg ctttctaatc ggctcgggag gaagctctgc agctctcttg ggaattaagc      540

tcaatctctg gactctctct ctttctcttt ctccccctcc ctctcctgcg aagaagctca      600

agacaaaacc aggaagccgg cgaccctcac ctcctcgggg gctgggagga aggaggaaaa      660

cgaaagtcgc cgccgccgcg ctgtcccccg agagctgcct ttcctcgggc atccctgggg      720

ctgccgcggg acctcgcagg gcggatataa agaaccgcgg ccttgggaag aggcggagac      780

cggcttttaa agaaagaagt cctgggtcct gcggtctggg gcgaggcaag ggcgcttttc      840

tgcccacgct ccccgtggcc catcgatccc ccgcgcgtcc gccgctgttc taaggagaga      900

agtgggggcc ccccaggctc gcgcgtggag cgaagcagca tgggcagtcg gtgcgcgctg      960

gccctggcgg tgctctcggc cttgctgtgt caggtaggcg ggcaggtggg ggcgccgcgg     1020

ccccgcgggg tctcacgggt agccggggcg cggggcagga gcgcgcgggg aggggcggac     1080

agcggcacgg gccgcgccag ccacggcccg gaagatgaat cccgggggcg acgaccccag     1140

cgccggccgt gcagcgagcg cgctcggccc ctgagccctt ccaggctctc cgcacacccc     1200

ccacccaggc ctcacgcccc ctagctcggg cgggacccgc gtcctcacgc ccccgccctc     1260

ccccgtgcag gtctggagct ctggggtgtt cgaactgaag ctgcaggagt tcgtcaacaa     1320

gaaggggctg ctggggaacc gcaactgctg ccgcgggggc gcggggccac cgccgtgcgc     1380

ctgccggacc ttcttccgcg tgtgcctcaa gcactaccag gccagcgtgt cccccgagcc     1440

gccctgcacc tacggcagcg ccgtcacccc cgtgctgggc gtcgactcct tcagtctgcc     1500

cgacggcggg ggcgccgact ccgcgttcag caaccccatc cgcttcccct tcggcttcac     1560

ctggccggtg agtgccgcac ctgcgcgcgc cgggccggcc ctgaagctgg gcgggctgca     1620

ggacgcgctg ggatcccgcc ttgggcgctc ggtggcggga cctcggggac cccgcgaggc     1680

gcaggtgggc gctgcgatct gcctagcggc ggccccagga ctccagccca gcagcgcgga     1740

cacctcgccc cggggccccg cggcctgcag gaggggaccg cgctggggcg aggaggagag     1800

gccgagcgcg cccgggagat ttccgtatcc ggcctctgtg ccaggtctcc agtcagaggc     1860

gccccttcac gtgggaaggt tctggtttcc cgactcctag acgcgttggt ggcgcgatta     1920

cccgcgcagc gcgaccgcta ccacccggag cgtgcccatc ccccaagaaa aatgacaagg     1980

gccctcgggc ctcttccacc ccatcctgcc tgcattctct ctctctctct aattaaaaaa     2040

acaacgtaat atcctgtagt acaggctgaa aaaacacgtc aggaaaccac tctttaaaaa     2100

gttcttccat ttccttaggg aaggtgagag caggcaggag gtgcgtggag accctctcca     2160

gacacgctgc cccagacctg cagccttcag gcctctgttg ctgacctggc tgttaggaat     2220

gactgctttt tgccgttttc ttttcgttac ctttctgggt tgtctaacgt cttctcccct     2280

ctctcccagg gcaccttctc tctgattatt gaagctctcc acacagattc tcctgatgac     2340

ctcgcaacag gtaaaaacaa aacccaaacc ccaaaactgc tttccccagt taatagcatt     2400

ggactttgcc cacccatccc ccagccaaac ccggacagct ttcattctgc acgtgcccca     2460

gaaagttcag ggtggagcag cttgggcctc cttcccgtgc tgaatgtctc ggcccacccc     2520

cgctctgtcc cgagtcacag ggttctcgtt cagaaccaac caggagcatc ttctccccgt     2580

agaaaaccca gaaagactca tcagccgcct ggccacccag aggcacctga cggtgggcga     2640

ggagtggtcc caggacctgc acagcagcgg ccgcacggac ctcaagtact cctaccgctt     2700

cgtgtgtgac gaacactact acggagaggg ctgctccgtt ttctgccgtc cccgggacga     2760

tgccttcggc cacttcacct gtggggagcg tggggagaaa gtgtgcaacc ctggctggaa     2820

agggccctac tgcacagagc gtgagtctct gggaaggcac cgctggctca ctcgtccacg     2880

aacacggacc gcgcgcaggg acggggcttc ctgagccacg gggggcttgg gactgtagag     2940

atgttctggt ggggaaactg aggcccagag gacagaagtg gattgctata agtcacagct     3000

cgtcagtggg ggggttgggg tcaacgcaga cattttaaca tcccaggctg tgtttatcca     3060

ctatcggaac tgcctttctt aatcagggag gattttagag acagggccag gggtcaggaa     3120

gtaaagccag tgctaccccc agggtgtgtg tattagagag ggagaggagg aaggaaggga     3180

ggaacacaga gagagcttgt gtgtcagggg caccatttca acccgagttc ccagtgctgg     3240

aacagcatca cactgggaaa cgttccattt tctctctgga gctggtgtgc ttgacctctc     3300

tggagcaaac gcctttccgg atactccctg tgacacgcac tgtctatgct ggccagagag     3360

caggctttca ctcctgtggg ctgctgaggc caggtctcca aggcctgtgt gggcgagggg     3420

tgcacagccc cgtctggctt gaatgctcag gcagcacctt gtctggagaa gcaatgtctt     3480

cccaatagtg acagaggctc tacctgcctc ttattaggta ttgatgtgtc aatgtcatgg     3540

caggcaggtg actagggcag ggttggggcc gtgctggctc ctggttctgg ctcatgggga     3600

cctcaggagc cctctctcca gctgactgag gcctcgcctg cacgcctggc cgtcccagcc     3660

cattggtacc ggatttctct acagctgggg attgggtagg tcctggagct gcccagaaac     3720

tccagggaac tgtcattctc cttccttgga actggacaac cttggagagg ggctctggga     3780

ggcccagaac ctctggcagg agctgggtag tgcctggggt tgagggtggg tcttcccatt     3840

cactgagtgc cttgatgtcc ttgctcctta gcttcccaaa ttccctccgg aacttactga     3900

gctccttcta agctttgcct tggcctgaac tggttctggg gaaaaacaaa aaaacaaaaa     3960

acaacttgtg gagctgcttg ttaatgagtt tcataaccag gcagcaagag ccagctccaa     4020

gcctcaagcc cactgtctac tccctgccct gcgggagcct ctggccagtc tgctgcctcc     4080

cacccttcct ccctgcctct cttcaccaca gggtagccag aaacttaaac ttttttcttc     4140

aaacactgaa gtctctcccc gcccccagct cgcgcgtgcc atagattaga tctctccggg     4200

gataggcgca gggacacccg ccggctccca ttggcggaag gggtgcgtgt gcgtgtgtgt     4260

gtgtgtgtgt gtgtgtacac gcgaggggtg tgtgtgagga ggtggggccg ggggcgcggg     4320

ggaggccggc attgttgcgc tggggcagct gccgtggagg acagacaatg gagcagctgt     4380

cctgccctgg caccctgcat accagctgtc cactcttatc tgcacacaca ctttctggga     4440

tattaagagg tggagctttg tgcacagaat tgggaagtgg gggaggagga gggggaagac     4500

ttctgaccct ctcttagaag aaaaggggat agggtggggg tgggggcttc cgagagccct     4560

tttgtccttg agcccctgtg ttaagaagaa tgctcatccc cagggctgag tcaagtccca     4620

ggctactagg caggggggtc agtcctccac aacctgggaa gattaactca gctgggattt     4680

gctgactgaa gccggcgagt tgtgtcctgg ccccaagggc ggcagccctg ttgggacgta     4740

cttggcgtgg ggcttgaccc tgtttttcct ttgcttgtag cgatctgcct gcctggatgt     4800

gatgagcagc atggattttg tgacaaacca ggggaatgca agtaagtctg cacaaggtgg     4860

tgttttgttt tgttgccttt tcttgttatc ttttcacagc tggtgtattt gtaaaaacag     4920

ccctaggtga tcattcgaaa aactccagta agattgattg aacagggggc cgttttctca     4980

tgtttctact taatcaatgt ttggcagcat gtaaggtcat ggagttgtca ttcgtctaag     5040

ccccttaacg gctatgagaa tttacagata gtagtttaaa aagagttggc acaggaaatg     5100

atagtatagt tcaatggttc tcaaatgttg cctcatccta gaatcactca gggagtgatt     5160

tttgagatgc tgacactggt gctgccctaa cacccaagaa gccagaacct ctggtggggc     5220

ccaggcccag gctgcagctc ccaaggtgac ccagtgttct gctaatctgg agaaccagag     5280

gctcactggt gctgcgggaa gatggtttct agggtgagaa tgtccactgc aaagccagca     5340

acagtcaacg tccatctgag tcttctgctt ttctccaagg tgcagagtgg gctggcaggg     5400

ccggtactgt gacgagtgta tccgctatcc aggctgtctc catggcacct gccagcagcc     5460

ctggcagtgc aactgccagg aaggctgggg gggccttttc tgcaaccagg gtaagccttc     5520

tctccctgag gcagcctgct ccctccagag cagccctgga cttccctggc tgtttgatca     5580

ctggaaaaat aaagtcttcc tgcatttgat gtcgagcttc ctatctccta cttttcctgt     5640

ccccaccctt cacagacctg aactactgca cacaccataa gccctgcaag aatggagcca     5700

cctgcaccaa cacgggccag gggagctaca cttgctcttg ccggcctggg tacacaggtg     5760

ccacctgcga gctggggatt gacgagtgtg accccagccc ttgtaagaac ggagggagct     5820

gcacggtgag tcggaggctc catggcatct cacccggaag ctggggtgcc ctggtgttga     5880

atggagtgtg tgggctcctt ggagcaactt tggaaagcct tttctgacct ctccatcgtg     5940

taggatctcg agaacagcta ctcctgtacc tgcccacccg gcttctacgg caaaatctgt     6000

gaattgagtg ccatgacctg tgcggacggc ccttgcttta acgggggtcg gtgctcagac     6060

agccccgatg gagggtacag ctgccgctgc cccgtgggct actccggctt caactgtgag     6120

aagaaaattg actactgcag ctcttcaccc tgttctaatg gtaagggggc agctggtgat     6180

tgctcagaga ctcgggcgag cggtcaatac tgaggtggca ttaaaaacaa gcatttgtga     6240

gtgacctcga gtttatgaat cacttttatc cagaccgcca ggaattctcg atggaaactc     6300

tatctttgag tctggaaagg cctggggaat gagagaggcc agggcatttg ttatgaagtt     6360

ctctgtggaa acctagacca agcagtgaat gacttgctca gggccacaag gtgcttcggg     6420

cacctgcggc cgcctgaggt tcagtaagtg atgcccacag gtgccggcca ctccagcttg     6480

ggaggatggc ccagctgtgt ggccacccag cacagtagtt gggggtgtcc ctgagtgagg     6540

acagagagcc tcctgctagc agcgaggggc tggctgccca aaggagacac acagcaagga     6600

gagctgggcc ccagatgtgc cggagcattc cggaatggtc atccttcccc tccctccctc     6660

ccctgttgtc agtgcctgct cctctcactt gctgtgtaac tgtgggcaag gacaccctcg     6720

ttaagcctca gtttccccat ctgaaacctg ggtcgagtgg cacatgctct tgcccggctg     6780

ttgtggcgac taatgcagcc accagagtgt tctgcacagc gcctgtccag atgctggccg     6840

tgtggtttct gacttgtaga gctagacctg gacacctctc gtatttgagg tcctaaacca     6900

tgtcaccttg cgctgtggac tcattcaggc cacagactgt ctttggtttg tctggtttct     6960

acagtgtcag acagatagat gcttcagagt gactttttgg tgaacaaacc tacgaggaga     7020

cacgtgatgt tcatgtccct gtgttccagg tgccaagtgt gtggacctcg gtgatgccta     7080

cctgtgccgc tgccaggccg gcttctcggg gaggcactgt gacgacaacg tggacgactg     7140

cgcctcctcc ccgtgcgcca acgggggcac ctgccgggat ggcgtgaacg acttctcctg     7200

cacctgcccg cctggctaca cgggcaggaa ctgcagtgcc cccgtcagca ggtgcgagca     7260

cgcaccctgc cacaatgggg ccacctgcca cgagaggggc caccgctatg tgtgcgagtg     7320

tgcccgaggc tacgggggtc ccaactgcca gttcctgctc cccgagctgc ccccgggccc     7380

agcggtggtg gacctcactg agaagctaga gggccagggc gggccattcc cctgggtggc     7440

cgtgtgcgcc ggggtcatcc ttgtcctcat gctgctgctg ggctgtgccg ctgtggtggt     7500

ctgcgtccgg ctgaggctgc agaagcaccg gcccccagcc gacccctgcc ggggggagac     7560

ggagaccatg aacaacctgg ccaactgcca gcgtgagaag gacatctcag tcagcatcat     7620

cggggccacg cagatcaaga acaccaacaa gaaggcggac ttccacgggg accacagcgc     7680

cgacaagaat ggcttcaagg cccgctaccc agcggtggac tataacctcg tgcaggacct     7740

caagggtgac gacaccgccg tcagggacgc gcacagcaag cgtgacacca agtgccagcc     7800

ccagggctcc tcaggggagg agaaggggac cccgaccaca ctcagggggt gcgtgctgcg     7860

ggccgggcat caggaggggg tacctggggg gtgtcttcct ggaaccactg ctccgtttct     7920

cttcccaaat gttctcatgc attcattgtg gattttctct attttccttt tagtggagaa     7980

gcatctgaaa gaaaaaggcc ggactcgggc tgttcaactt caaaagacac caagtaccag     8040

tcggtgtacg tcatatccga ggagaaggat gagtgcgtca tagcaactga ggtcagtgca     8100

ggcagcagcc gctccctcct cctcggcatg ggagcacctg aagctggagc acgggaatcg     8160

gtctcaggct aacttcccat ttgtcttgtg gccccccagg tgtaaaatgg aagtgagatg     8220

gcaagactcc cgtttctctt aaaataagta aaattccaag gatatatgcc ccaacgaatg     8280

ctgctgaaga ggagggaggc ctcgtggact gctgctgaga aaccgagttc agaccgagca     8340

ggttctcctc ctgaggtcct cgacgcctgc cgacagcctg tcgcggcccg gccgcctgcg     8400

gcactgcctt ccgtgacgtc gccgttgcac tatggacagt tgctcttaag agaatatata     8460

tttaaatggg tgaactgaat tacgcataag aagcatgcac tgcctgagtg tatattttgg     8520

attcttatga gccagtcttt tcttgaatta gaaacacaaa cactgccttt attgtccttt     8580

ttgatacgaa gatgtgcttt ttctagatgg aaaagatgtg tgttattttt tggatttgta     8640

aaaatatttt tcatgatatc tgtaaagctt gagtattttg tgatgttcgt tttttataat     8700

ttaaattttg gtaaatatgt acaaaggcac ttcgggtcta tgtgactata tttttttgta     8760

tataaatgta tttatggaat attgtgcaaa tgttatttga gttttttact gttttgttaa     8820

tgaagaaatt cctttttaaa atatttttcc aaaataaatt ttatgaatga caa            8873


<210>  2
<211>  3779
<212>  DNA
<213>  Homo sapiens

<400>  2
actgaccatt tggcgatcca ttgagaggag ggtttggaaa agtggctcct ttgtgacagc       60

tctcgccaga ttggggggct gctgatttgc atctcattag ccatgcgggc ggccggctga      120

atataagggc ggcaggcgcc ggcgagagcc agatcctctg cgcgcacccg cggagacccg      180

acccggccga gggcagagcg caggggaacc cgggcagccg cggcgcagag cctcctccca      240

cggcccggcc cctccggtcc tgcgcgtgtg tactggatgg cattggctgg attcatcgga      300

aagacgcgga tctttgctgt gacaccggag atcggagccc ggagtgctcc cggaacgacc      360

gccgccgccg agtgacaccg ggccgcgatc cgcaggggcc gccgcgcaca cccgccgccg      420

ccgaccgtcc cctcagcgcg cgccgctggc cccggattat cgccttgccc gtgggatttc      480

cagaccgcgg ctttctaatc ggctcgggag gaagctctgc agctctcttg ggaattaagc      540

tcaatctctg gactctctct ctttctcttt ctccccctcc ctctcctgcg aagaagctca      600

agacaaaacc aggaagccgg cgaccctcac ctcctcgggg gctgggagga aggaggaaaa      660

cgaaagtcgc cgccgccgcg ctgtcccccg agagctgcct ttcctcgggc atccctgggg      720

ctgccgcggg acctcgcagg gcggatataa agaaccgcgg ccttgggaag aggcggagac      780

cggcttttaa agaaagaagt cctgggtcct gcggtctggg gcgaggcaag ggcgcttttc      840

tgcccacgct ccccgtggcc catcgatccc ccgcgcgtcc gccgctgttc taaggagaga      900

agtgggggcc ccccaggctc gcgcgtggag cgaagcagca tgggcagtcg gtgcgcgctg      960

gccctggcgg tgctctcggc cttgctgtgt caggtctgga gctctggggt gttcgaactg     1020

aagctgcagg agttcgtcaa caagaagggg ctgctgggga accgcaactg ctgccgcggg     1080

ggcgcggggc caccgccgtg cgcctgccgg accttcttcc gcgtgtgcct caagcactac     1140

caggccagcg tgtcccccga gccgccctgc acctacggca gcgccgtcac ccccgtgctg     1200

ggcgtcgact ccttcagtct gcccgacggc gggggcgccg actccgcgtt cagcaacccc     1260

atccgcttcc ccttcggctt cacctggccg ggcaccttct ctctgattat tgaagctctc     1320

cacacagatt ctcctgatga cctcgcaaca gaaaacccag aaagactcat cagccgcctg     1380

gccacccaga ggcacctgac ggtgggcgag gagtggtccc aggacctgca cagcagcggc     1440

cgcacggacc tcaagtactc ctaccgcttc gtgtgtgacg aacactacta cggagagggc     1500

tgctccgttt tctgccgtcc ccgggacgat gccttcggcc acttcacctg tggggagcgt     1560

ggggagaaag tgtgcaaccc tggctggaaa gggccctact gcacagagcc gatctgcctg     1620

cctggatgtg atgagcagca tggattttgt gacaaaccag gggaatgcaa gtgcagagtg     1680

ggctggcagg gccggtactg tgacgagtgt atccgctatc caggctgtct ccatggcacc     1740

tgccagcagc cctggcagtg caactgccag gaaggctggg ggggcctttt ctgcaaccag     1800

gacctgaact actgcacaca ccataagccc tgcaagaatg gagccacctg caccaacacg     1860

ggccagggga gctacacttg ctcttgccgg cctgggtaca caggtgccac ctgcgagctg     1920

gggattgacg agtgtgaccc cagcccttgt aagaacggag ggagctgcac ggatctcgag     1980

aacagctact cctgtacctg cccacccggc ttctacggca aaatctgtga attgagtgcc     2040

atgacctgtg cggacggccc ttgctttaac gggggtcggt gctcagacag ccccgatgga     2100

gggtacagct gccgctgccc cgtgggctac tccggcttca actgtgagaa gaaaattgac     2160

tactgcagct cttcaccctg ttctaatggt gccaagtgtg tggacctcgg tgatgcctac     2220

ctgtgccgct gccaggccgg cttctcgggg aggcactgtg acgacaacgt ggacgactgc     2280

gcctcctccc cgtgcgccaa cgggggcacc tgccgggatg gcgtgaacga cttctcctgc     2340

acctgcccgc ctggctacac gggcaggaac tgcagtgccc ccgtcagcag gtgcgagcac     2400

gcaccctgcc acaatggggc cacctgccac gagaggggcc accgctatgt gtgcgagtgt     2460

gcccgaggct acgggggtcc caactgccag ttcctgctcc ccgagctgcc cccgggccca     2520

gcggtggtgg acctcactga gaagctagag ggccagggcg ggccattccc ctgggtggcc     2580

gtgtgcgccg gggtcatcct tgtcctcatg ctgctgctgg gctgtgccgc tgtggtggtc     2640

tgcgtccggc tgaggctgca gaagcaccgg cccccagccg acccctgccg gggggagacg     2700

gagaccatga acaacctggc caactgccag cgtgagaagg acatctcagt cagcatcatc     2760

ggggccacgc agatcaagaa caccaacaag aaggcggact tccacgggga ccacagcgcc     2820

gacaagaatg gcttcaaggc ccgctaccca gcggtggact ataacctcgt gcaggacctc     2880

aagggtgacg acaccgccgt cagggacgcg cacagcaagc gtgacaccaa gtgccagccc     2940

cagggctcct caggggagga gaaggggacc ccgaccacac tcaggggtgg agaagcatct     3000

gaaagaaaaa ggccggactc gggctgttca acttcaaaag acaccaagta ccagtcggtg     3060

tacgtcatat ccgaggagaa ggatgagtgc gtcatagcaa ctgaggtgta aaatggaagt     3120

gagatggcaa gactcccgtt tctcttaaaa taagtaaaat tccaaggata tatgccccaa     3180

cgaatgctgc tgaagaggag ggaggcctcg tggactgctg ctgagaaacc gagttcagac     3240

cgagcaggtt ctcctcctga ggtcctcgac gcctgccgac agcctgtcgc ggcccggccg     3300

cctgcggcac tgccttccgt gacgtcgccg ttgcactatg gacagttgct cttaagagaa     3360

tatatattta aatgggtgaa ctgaattacg cataagaagc atgcactgcc tgagtgtata     3420

ttttggattc ttatgagcca gtcttttctt gaattagaaa cacaaacact gcctttattg     3480

tcctttttga tacgaagatg tgctttttct agatggaaaa gatgtgtgtt attttttgga     3540

tttgtaaaaa tatttttcat gatatctgta aagcttgagt attttgtgat gttcgttttt     3600

tataatttaa attttggtaa atatgtacaa aggcacttcg ggtctatgtg actatatttt     3660

tttgtatata aatgtattta tggaatattg tgcaaatgtt atttgagttt tttactgttt     3720

tgttaatgaa gaaattcctt tttaaaatat ttttccaaaa taaattttat gaatgacaa      3779


<210>  3
<211>  2172
<212>  DNA
<213>  Homo sapiens

<400>  3
atgggcagtc ggtgcgcgct ggccctggcg gtgctctcgg ccttgctgtg tcaggtctgg       60

agctctgggg tgttcgaact gaagctgcag gagttcgtca acaagaaggg gctgctgggg      120

aaccgcaact gctgccgcgg gggcgcgggg ccaccgccgt gcgcctgccg gaccttcttc      180

cgcgtgtgcc tcaagcacta ccaggccagc gtgtcccccg agccgccctg cacctacggc      240

agcgccgtca cccccgtgct gggcgtcgac tccttcagtc tgcccgacgg cgggggcgcc      300

gactccgcgt tcagcaaccc catccgcttc cccttcggct tcacctggcc gggcaccttc      360

tctctgatta ttgaagctct ccacacagat tctcctgatg acctcgcaac agaaaaccca      420

gaaagactca tcagccgcct ggccacccag aggcacctga cggtgggcga ggagtggtcc      480

caggacctgc acagcagcgg ccgcacggac ctcaagtact cctaccgctt cgtgtgtgac      540

gaacactact acggagaggg ctgctccgtt ttctgccgtc cccgggacga tgccttcggc      600

cacttcacct gtggggagcg tggggagaaa gtgtgcaacc ctggctggaa agggccctac      660

tgcacagagc cgatctgcct gcctggatgt gatgagcagc atggattttg tgacaaacca      720

ggggaatgca agtgcagagt gggctggcag ggccggtact gtgacgagtg tatccgctat      780

ccaggctgtc tccatggcac ctgccagcag ccctggcagt gcaactgcca ggaaggctgg      840

gggggccttt tctgcaacca ggacctgaac tactgcacac accataagcc ctgcaagaat      900

ggagccacct gcaccaacac gggccagggg agctacactt gctcttgccg gcctgggtac      960

acaggtgcca cctgcgagct ggggattgac gagtgtgacc ccagcccttg taagaacgga     1020

gggagctgca cggatctcga gaacagctac tcctgtacct gcccacccgg cttctacggc     1080

aaaatctgtg aattgagtgc catgacctgt gcggacggcc cttgctttaa cgggggtcgg     1140

tgctcagaca gccccgatgg agggtacagc tgccgctgcc ccgtgggcta ctccggcttc     1200

aactgtgaga agaaaattga ctactgcagc tcttcaccct gttctaatgg tgccaagtgt     1260

gtggacctcg gtgatgccta cctgtgccgc tgccaggccg gcttctcggg gaggcactgt     1320

gacgacaacg tggacgactg cgcctcctcc ccgtgcgcca acgggggcac ctgccgggat     1380

ggcgtgaacg acttctcctg cacctgcccg cctggctaca cgggcaggaa ctgcagtgcc     1440

cccgtcagca ggtgcgagca cgcaccctgc cacaatgggg ccacctgcca cgagaggggc     1500

caccgctatg tgtgcgagtg tgcccgaggc tacgggggtc ccaactgcca gttcctgctc     1560

cccgagctgc ccccgggccc agcggtggtg gacctcactg agaagctaga gggccagggc     1620

gggccattcc cctgggtggc cgtgtgcgcc ggggtcatcc ttgtcctcat gctgctgctg     1680

ggctgtgccg ctgtggtggt ctgcgtccgg ctgaggctgc agaagcaccg gcccccagcc     1740

gacccctgcc ggggggagac ggagaccatg aacaacctgg ccaactgcca gcgtgagaag     1800

gacatctcag tcagcatcat cggggccacg cagatcaaga acaccaacaa gaaggcggac     1860

ttccacgggg accacagcgc cgacaagaat ggcttcaagg cccgctaccc agcggtggac     1920

tataacctcg tgcaggacct caagggtgac gacaccgccg tcagggacgc gcacagcaag     1980

cgtgacacca agtgccagcc ccagggctcc tcaggggagg agaaggggac cccgaccaca     2040

ctcaggggtg gagaagcatc tgaaagaaaa aggccggact cgggctgttc aacttcaaaa     2100

gacaccaagt accagtcggt gtacgtcata tccgaggaga aggatgagtg cgtcatagca     2160

actgaggtgt aa                                                         2172


<210>  4
<211>  723
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Ser Arg Cys Ala Leu Ala Leu Ala Val Leu Ser Ala Leu Leu 
1               5                   10                  15      


Cys Gln Val Trp Ser Ser Gly Val Phe Glu Leu Lys Leu Gln Glu Phe 
            20                  25                  30          


Val Asn Lys Lys Gly Leu Leu Gly Asn Arg Asn Cys Cys Arg Gly Gly 
        35                  40                  45              


Ala Gly Pro Pro Pro Cys Ala Cys Arg Thr Phe Phe Arg Val Cys Leu 
    50                  55                  60                  


Lys His Tyr Gln Ala Ser Val Ser Pro Glu Pro Pro Cys Thr Tyr Gly 
65                  70                  75                  80  


Ser Ala Val Thr Pro Val Leu Gly Val Asp Ser Phe Ser Leu Pro Asp 
                85                  90                  95      


Gly Gly Gly Ala Asp Ser Ala Phe Ser Asn Pro Ile Arg Phe Pro Phe 
            100                 105                 110         


Gly Phe Thr Trp Pro Gly Thr Phe Ser Leu Ile Ile Glu Ala Leu His 
        115                 120                 125             


Thr Asp Ser Pro Asp Asp Leu Ala Thr Glu Asn Pro Glu Arg Leu Ile 
    130                 135                 140                 


Ser Arg Leu Ala Thr Gln Arg His Leu Thr Val Gly Glu Glu Trp Ser 
145                 150                 155                 160 


Gln Asp Leu His Ser Ser Gly Arg Thr Asp Leu Lys Tyr Ser Tyr Arg 
                165                 170                 175     


Phe Val Cys Asp Glu His Tyr Tyr Gly Glu Gly Cys Ser Val Phe Cys 
            180                 185                 190         


Arg Pro Arg Asp Asp Ala Phe Gly His Phe Thr Cys Gly Glu Arg Gly 
        195                 200                 205             


Glu Lys Val Cys Asn Pro Gly Trp Lys Gly Pro Tyr Cys Thr Glu Pro 
    210                 215                 220                 


Ile Cys Leu Pro Gly Cys Asp Glu Gln His Gly Phe Cys Asp Lys Pro 
225                 230                 235                 240 


Gly Glu Cys Lys Cys Arg Val Gly Trp Gln Gly Arg Tyr Cys Asp Glu 
                245                 250                 255     


Cys Ile Arg Tyr Pro Gly Cys Leu His Gly Thr Cys Gln Gln Pro Trp 
            260                 265                 270         


Gln Cys Asn Cys Gln Glu Gly Trp Gly Gly Leu Phe Cys Asn Gln Asp 
        275                 280                 285             


Leu Asn Tyr Cys Thr His His Lys Pro Cys Lys Asn Gly Ala Thr Cys 
    290                 295                 300                 


Thr Asn Thr Gly Gln Gly Ser Tyr Thr Cys Ser Cys Arg Pro Gly Tyr 
305                 310                 315                 320 


Thr Gly Ala Thr Cys Glu Leu Gly Ile Asp Glu Cys Asp Pro Ser Pro 
                325                 330                 335     


Cys Lys Asn Gly Gly Ser Cys Thr Asp Leu Glu Asn Ser Tyr Ser Cys 
            340                 345                 350         


Thr Cys Pro Pro Gly Phe Tyr Gly Lys Ile Cys Glu Leu Ser Ala Met 
        355                 360                 365             


Thr Cys Ala Asp Gly Pro Cys Phe Asn Gly Gly Arg Cys Ser Asp Ser 
    370                 375                 380                 


Pro Asp Gly Gly Tyr Ser Cys Arg Cys Pro Val Gly Tyr Ser Gly Phe 
385                 390                 395                 400 


Asn Cys Glu Lys Lys Ile Asp Tyr Cys Ser Ser Ser Pro Cys Ser Asn 
                405                 410                 415     


Gly Ala Lys Cys Val Asp Leu Gly Asp Ala Tyr Leu Cys Arg Cys Gln 
            420                 425                 430         


Ala Gly Phe Ser Gly Arg His Cys Asp Asp Asn Val Asp Asp Cys Ala 
        435                 440                 445             


Ser Ser Pro Cys Ala Asn Gly Gly Thr Cys Arg Asp Gly Val Asn Asp 
    450                 455                 460                 


Phe Ser Cys Thr Cys Pro Pro Gly Tyr Thr Gly Arg Asn Cys Ser Ala 
465                 470                 475                 480 


Pro Val Ser Arg Cys Glu His Ala Pro Cys His Asn Gly Ala Thr Cys 
                485                 490                 495     


His Glu Arg Gly His Arg Tyr Val Cys Glu Cys Ala Arg Gly Tyr Gly 
            500                 505                 510         


Gly Pro Asn Cys Gln Phe Leu Leu Pro Glu Leu Pro Pro Gly Pro Ala 
        515                 520                 525             


Val Val Asp Leu Thr Glu Lys Leu Glu Gly Gln Gly Gly Pro Phe Pro 
    530                 535                 540                 


Trp Val Ala Val Cys Ala Gly Val Ile Leu Val Leu Met Leu Leu Leu 
545                 550                 555                 560 


Gly Cys Ala Ala Val Val Val Cys Val Arg Leu Arg Leu Gln Lys His 
                565                 570                 575     


Arg Pro Pro Ala Asp Pro Cys Arg Gly Glu Thr Glu Thr Met Asn Asn 
            580                 585                 590         


Leu Ala Asn Cys Gln Arg Glu Lys Asp Ile Ser Val Ser Ile Ile Gly 
        595                 600                 605             


Ala Thr Gln Ile Lys Asn Thr Asn Lys Lys Ala Asp Phe His Gly Asp 
    610                 615                 620                 


His Ser Ala Asp Lys Asn Gly Phe Lys Ala Arg Tyr Pro Ala Val Asp 
625                 630                 635                 640 


Tyr Asn Leu Val Gln Asp Leu Lys Gly Asp Asp Thr Ala Val Arg Asp 
                645                 650                 655     


Ala His Ser Lys Arg Asp Thr Lys Cys Gln Pro Gln Gly Ser Ser Gly 
            660                 665                 670         


Glu Glu Lys Gly Thr Pro Thr Thr Leu Arg Gly Gly Glu Ala Ser Glu 
        675                 680                 685             


Arg Lys Arg Pro Asp Ser Gly Cys Ser Thr Ser Lys Asp Thr Lys Tyr 
    690                 695                 700                 


Gln Ser Val Tyr Val Ile Ser Glu Glu Lys Asp Glu Cys Val Ile Ala 
705                 710                 715                 720 


Thr Glu Val 
            


<210>  5
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  5

Met Gly Ser Arg Cys Ala Leu Ala Leu Ala Val Leu Ser Ala Leu Leu 
1               5                   10                  15      


Cys Gln Val Trp Ser Ser Gly Val Phe Glu Leu Lys Leu Gln Glu Phe 
            20                  25                  30          


Val Asn Lys Lys Gly Leu Leu Gly Asn Arg Asn Cys Cys Arg Gly Gly 
        35                  40                  45              


Ala Gly Pro Pro Pro Cys Ala Cys Arg Thr Phe Phe Arg Val Cys Leu 
    50                  55                  60                  


Lys His Tyr Gln Ala Ser Val Ser Pro Glu Pro Pro Cys Thr Tyr Gly 
65                  70                  75                  80  


Ser Ala Val Thr Pro Val Leu Gly Val Asp Ser Phe Ser Leu Pro Asp 
                85                  90                  95      


Gly Gly Gly Ala Asp Ser Ala Phe Ser Asn Pro Ile Arg Phe Pro Phe 
            100                 105                 110         


Gly Phe Thr Trp Pro Gly Thr Phe Ser Leu Ile Ile Glu Ala Leu His 
        115                 120                 125             


Thr Asp Ser Pro Asp Asp Leu Ala Thr Glu Asn Pro Glu Arg Leu Ile 
    130                 135                 140                 


Ser Arg Leu Ala Thr Gln Arg His Leu Thr Val Gly Glu Glu Trp Ser 
145                 150                 155                 160 


Gln Asp Leu His Ser Ser Gly Arg Thr Asp Leu Lys Tyr Ser Tyr Arg 
                165                 170                 175     


Phe Val Cys Asp Glu His Tyr Tyr Gly Glu Gly Cys Ser Val Phe Cys 
            180                 185                 190         


Arg Pro Arg Asp Asp Ala Phe Gly His Phe Thr Cys Gly Glu Arg Gly 
        195                 200                 205             


Glu Lys Val Cys Asn Pro Gly Trp Lys Gly Pro Tyr Cys Thr Glu Pro 
    210                 215                 220                 


Ile Cys Leu Pro Gly Cys Asp Glu Gln His Gly Phe Cys Asp Lys Pro 
225                 230                 235                 240 


Gly Glu Cys Lys Cys Arg Val Gly Trp Gln Gly Arg Tyr Cys Asp Glu 
                245                 250                 255     


Cys Ile Arg Tyr Pro Gly Cys Leu His Gly Thr Cys Gln Gln Pro Trp 
            260                 265                 270         


Gln Cys Asn Cys Gln Glu Gly Trp Gly Gly Leu Phe Cys Asn Gln Asp 
        275                 280                 285             


Leu Asn Tyr Cys Thr His His Lys Pro Cys Lys Asn Gly Ala Thr Cys 
    290                 295                 300                 


Thr Asn Thr Gly Gln Gly Ser Tyr Thr Cys Ser Cys Arg Pro Gly Tyr 
305                 310                 315                 320 


Thr Gly Ala Thr Cys Glu Leu Gly Ile Asp Glu Cys Asp Pro Ser Pro 
                325                 330                 335     


Cys Lys Asn Gly Gly Ser Cys Thr Asp Leu Glu Asn Ser Tyr Ser Cys 
            340                 345                 350         


Thr Cys Pro Pro Gly Phe Tyr Gly Lys Ile Cys Glu Leu Ser Ala Met 
        355                 360                 365             


Thr Cys Ala Asp Gly Pro Cys Phe Asn Gly Gly Arg Cys Ser Asp Ser 
    370                 375                 380                 


Pro Asp Gly Gly Tyr Ser Cys Arg Cys Pro Val Gly Tyr Ser Gly Phe 
385                 390                 395                 400 


Asn Cys Glu Lys Lys Ile Asp Tyr Cys Ser Ser Ser Pro Cys Ser Asn 
                405                 410                 415     


Gly Ala Lys Cys Val Asp Leu Gly Asp Ala Tyr Leu Cys Arg Cys Gln 
            420                 425                 430         


Ala Gly Phe Ser Gly Arg His Cys Asp Asp Asn Val Asp Asp Cys Ala 
        435                 440                 445             


Ser Ser Pro Cys Ala Asn Gly Gly Thr Cys Arg Asp Gly Val Asn Asp 
    450                 455                 460                 


Phe Ser Cys Thr Cys Pro Pro Gly Tyr Thr Gly Arg Asn Cys Ser Ala 
465                 470                 475                 480 


Pro Val Ser Arg Cys Glu His Ala Pro Cys His Asn Gly Ala Thr Cys 
                485                 490                 495     


His Glu Arg Gly His Arg Tyr Val Cys Glu Cys Ala Arg Gly Tyr Gly 
            500                 505                 510         


Gly Pro Asn Cys Gln Phe Leu Leu Pro Glu Leu Pro Pro Gly Pro Ala 
        515                 520                 525             


Val Val Asp Leu Thr Glu Lys Leu 
    530                 535     


<210>  6
<211>  9734
<212>  DNA
<213>  Homo sapiens

<400>  6
agtagcggcg ctgcgcgcag gccgggaaca cgaggccaag agccgcagcc ccagccgcct       60

tggtgcagcg tacaccggca ctagcccgct tgcagcccca ggattagaca gaagacgcgt      120

cctcggcgcg gtcgccgccc agccgtagtc acctggatta cctacagcgg cagctgcagc      180

ggagccagcg agaaggccaa aggggagcag cgtcccgaga ggagcgcctc ttttcaggga      240

ccccgccggc tggcggacgc gcgggaaagc ggcgtcgcga acagagccag attgagggcc      300

cgcgggtgga gagagcgacg cccgagggga tggcggcagc gtcccggagc gcctctggct      360

gggcgctact gctgctggtg gcactttggc agcaggtaac acgtcccgcg ccctctccgt      420

cccctctgcc gcgctctggg cctcagcccc gggcaccagc tgagctgacc ggtcccctcc      480

ctccttccct cggtccctgt gcaatagcgc gcggccggct ccggcgtctt ccagctgcag      540

ctgcaggagt tcatcaacga gcgcggcgta ctggccagtg ggcggccttg cgagcccggc      600

tgccggactt tcttccgcgt ctgccttaag cacttccagg cggtcgtctc gcccggaccc      660

tgcaccttcg ggaccgtctc cacgccggta ttgggcacca actccttcgc tgtccgggac      720

gacagtagcg gcggggggcg caaccctctc caactgccct tcaatttcac ctggccggtg      780

agcacagcct gggcgcactg ggaggtcgca gaagccgaga gaggaggcgc cctgggacca      840

aagccccctc cccagatttc cttgtacaca cacccccacc cccaaaaagc ccaggatgca      900

ttctttcctg gctcttcccg actctctcct gagactgatc ccagaaaagg ctctcaccag      960

tctccgtctt cccagtttat gtcctcccgt ccccagctct tgggacacga ttttcattac     1020

ctaccactct ggggcggtac cctaccaccc cctcctccag tggctctccc ttacactctc     1080

ccgtctctca accctccctc taccgggggt tctcctctcg ccttccctgc tcaagcgcta     1140

cactgtgcac agccccgtta tgttgacccg ggcgcagtaa ctgaatcctg caattagatt     1200

aattaaacag gctgccgcaa ggcaccccca cctctccccg cttgctcatc tcgccatctc     1260

tccgtccccc cacccccttt cccagggtac cttctcgctc atcatcgaag cttggcacgc     1320

gccaggagac gacctgcggc caggtgagta gctcgctccg ccaccacagg ggggcgacac     1380

ggcgcagcgc cgaaagagtt aatctgttct aggcggggga agtgcgggct tgggggtggg     1440

aggcaggacg cttagcttgg cctggagctg cgccccgcgc tggacgctcg gattccgctc     1500

gctgcctgga ctcagagcac aattgcgttt cctgcgggtt atttttggcg tgggaacgcg     1560

gggagtacgg cggtgagaaa ggctgaagct gccagcgccg ctgacgggcc ccttcctgta     1620

ttttacacct ttcgcgaatt ccgctccttt ggaaagggaa taatggcttt gggatgttgt     1680

tctgacacag aggaaaagga tatttcagca gcacaacaat tctcactttg aaaaggaaaa     1740

aagaaaacca ttacccacct ctggaggcag aacccctgaa tgggcaccaa aggaccccct     1800

gctcccaggg tcctctctag cctggggagc ttttctttct ttttctcttt tttccatttt     1860

gacctctttt cctctttccc ctccctatct gcctccaaga ccctgggata tcttaacatc     1920

cttctattgt cccctttttg aatactatca ggccccctgc acatgcacac acgtagggca     1980

gctacgtagc ggggctttgg gtccctctgg cctgttcttg ctggcaggcg ggggtcatct     2040

ggataactgg gctgattggt tggctgatca ccatcatcac agccaagaag gacattggcc     2100

agccgtcact ggcacccttg gggactggcg acccttccct gacccgaccc tctgccccct     2160

cagaggcctt gccaccagat gcactcatca gcaagatcgc catccagggc tccctagctg     2220

tgggtcagaa ctggttattg gatgagcaaa ccagcaccct cacaaggctg cgctactctt     2280

accgggtcat ctgcagtgac aactactatg gagacaactg ctcccgcctg tgcaagaagc     2340

gcaatgacca cttcggccac tatgtgtgcc agccagatgg caacttgtcc tgcctgcccg     2400

gttggactgg ggaatattgc caacagcgta agcagtcaag ctcccacctg tgtggaaggg     2460

gagggtcccc tgaggaaaca cagtggagct tcttggtcac agcttgcctc ccttgaagag     2520

tgggtctggg cctcctacta gctgggcctc agggatgctg agggtgggct tgacctcaga     2580

cctcctgtct cttcccagtg ctcctcccat catgccaaag cccacaagaa ccccatcatg     2640

acattccatc cagtttggct tctccttccc tgtgccatta tttcacttta agacactcgg     2700

ggctcctctg ggaggccagg agtaggaaga gggcccagga gagctagggg atccccaggg     2760

ccagcaggtg agaatggggc ttaagagtcc ttggtatccc agcctcaccc agctctgtgt     2820

tcttccctta gctatctgtc tttcgggctg tcatgaacag aatggctact gcagcaagcc     2880

agcagagtgc ctgtgagtag gggacaggaa gtggtgagtg ggagccctcc cttggccaag     2940

gcctctcacc tcactctgcc tctctcttgt tccccagctg ccgcccaggc tggcagggcc     3000

ggctgtgtaa cgaatgcatc ccccacaatg gctgtcgcca cggcacctgc agcactccct     3060

ggcaatgtac ttgtgatgag ggctggggag gcctgttttg tgaccaaggt gagtcagggt     3120

gaagagaggg tgcagagggt gcaagagata tggggctggg gggtggaaat ccgattcgtc     3180

acctggatcc ttcttacttg gtgactgcag acttggcttt cccatgatct tccaaggatc     3240

ttgggtcttt taaggatctt tacaactggc ccagaatgag gcggtgggtc cttctccagg     3300

tgcggcggca gggggtggtg gagccagggt ggctgaaaaa cccagggggg tgacaaggtc     3360

ggcagcctgg aggttgcact cataaatcct agcaaagcca aagagagagg gatggcaggc     3420

tcagttcctc tttcaacccc gtagttacct attaaccccc tgagtgtttg cttaccttcc     3480

agggctgttt gagcagctct cccctaaaca gctgtccggt ggggtgtgcc caccggccac     3540

ctgaggctgt gggtgagctg ggcctctggg cggagtggca tctaaccgac ttttcggtgt     3600

gggcacaaac ggcctcccct gctcttacct agttaccacc tgcctgaacc catgcggtct     3660

ctacctggtg tttaggggta gtcactctct ggctatacag gggcctttca gccccaacct     3720

tgggggagga ggaagccttt tttcttgcat cctgctagcc agctgcagcc agctgcagct     3780

cccattttca ggatcaaatg ggtgcacctg ctgcccagag acaccggcgc aggcctgggt     3840

agggtgggca gagagcttgc cagggtggaa agaaattgcc taggccctga cttgctgtca     3900

acaaggggct tgggattcag tccctgtgtt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt     3960

ctgtcccttt actaccatcc ccaccccaac actcacacac ctggttcctg ctcattctct     4020

tccctctcca ccatatttgc tcccaggtga cacagtcata tactcatcat atgcaaacac     4080

agcacttgca ggccatatat ttactctgtc tggttctccc tccctgtcct tcccaaataa     4140

aaaaacaaat acttatattt caaaataccc ttgtaacacc tcttccttta aaaaatgccc     4200

gattactgcc tatggtggct ctcatctctc ctctaccatt tctacctgtt gaaattttat     4260

ccctccttcc aggcttatct cagctgcccc tcctccatga agccttttct gacttcctcc     4320

ccgacatgtg gccttgccct ctgctcttct tccttatctt catcctactt gggttggcag     4380

tttgtgagtt tccctggcag gacgtcttcc agttccagtt gtgttgtttc acttttggtt     4440

gactgcactg gtcatatgtg attcaaggtg ctttaagaaa catgattttc atcctggcta     4500

acacagtgaa accctgtctg tattaaaaat acaaaagtta gccaggtgtg gtggcaggca     4560

cctgtagccc cagctgctgg gaaggctgag gcaggagaat ggcgaagtag agcttgcagt     4620

gagccgaggt cgtgccactg cactccagcc tgagtgacag agcaagactc cgtctcaaaa     4680

aaaaaaaaaa aaaaaaaaaa aagaaacatg attttaggct gggtgcgatg gcctgtaatc     4740

ccagcacttt gggaggccga ggtaggtgga tcacttgaag tcaggagttc gagaccatcc     4800

tggccatcct ggtgaaaccc ctgtaaaaat acaaatatta atcgggcaca gtggcgcatg     4860

cctgtaatcc cagctactta gaaggttgag gtatgagaat cgcttgaacc cggaaggcga     4920

aggttgtagt gagcctatat cacatcactg cactccagcc tgggcgacag agtgagactc     4980

tgttaaaaaa aaaaaaaaaa gaaggaaaga aagagaaaga gagagaaaga aagaaagaaa     5040

gagaaagaaa aaagatttta ttggtggtgg aggaaggatg tttgggcctg ggagactttg     5100

agttgaggtg tctttgagcc aaacatgggg gcaaacatgg actgcaagga gcctggaggt     5160

gagtgcattc cctggccctg ctcagctgct tggttcctgt ttctgcagat ctcaactact     5220

gcacccacca ctccccatgc aagaatgggg caacgtgctc caacagtggg cagcgaagct     5280

acacctgcac ctgtcgccca ggctacactg gtgtggactg tgagctggag ctcagcgagt     5340

gtgacagcaa cccctgtcgc aatggaggca gctgtaaggt gaggcccaga ccagcgcagg     5400

aagacagagg tgtcaggtgg tgtctgggca tccctaacct aggcagttag tggatgtaca     5460

gccatggaca ggcattgtgg gcaggtggag cccagccttc agtcacacat ccctgccccc     5520

cagggtctga ctttggcccc tttatggtct ctctccagga ccaggaggat ggctaccact     5580

gcctgtgtcc tccgggctac tatggcctgc attgtgaaca cagcaccttg agctgcgccg     5640

actccccctg cttcaatggg ggctcctgcc gggagcgcaa ccagggggcc aactatgctt     5700

gtgaatgtcc ccccaacttc accggctcca actgcgagaa gaaagtggac aggtgcacca     5760

gcaacccctg tgccaacggt gcgtgctgct gccctgctaa cctggtggac tggccctggg     5820

gctgagagag acttctggtg agggagggtc aggagaggag cgaggcattg tctgccactc     5880

tggcccccca tctgctctgg agggcgaaga gcttgcttga tcagctgggg ggctgtggaa     5940

gcggagctgg ttagttgcac gcaggcctta ggagcagggg tggtatgcac cctgcatagc     6000

ttccattcct attcccatgt cagaaccccg tcctggctgg ggtggcctct gaccctcccc     6060

aggaagtcct gagctggaga gagggatgtt ggaggcttca tgtttctcct caaaggaggc     6120

agtgattcag tcagagccct gctcctggag gcctcatctt gccccgtgcc caggtagagc     6180

atgaggtagc atgaggcatc ttgaatgttt gcaccttttg aggcacaaag cctgttggta     6240

atccttgtct atctggctcc caggtgaccc tctgtgaggc aggcaggcag gcagcgctca     6300

ggagctggag aggggtggga agggctgaga gggagtctgc tctctcactg aagcctctgg     6360

cactgccatt tcttcatcac tgaatgggaa actataatac ctgtcctctg tccttcatgt     6420

ggttgtgaag atgaagtaaa acagtcatga ttgtacttat ccgagcatta actatatacc     6480

aaacatgggc tcttgccttc atgtaccttc ccggctatcc tatgaagggg ctagcattct     6540

actccagtct aacaaatggg gaaactgagg cttagagaca cggttaagca gcaagtgcca     6600

gatctcaggc cacagagtga cagctgaggt cccaactcaa gcctatctgt ctgattctac     6660

gttaaagttc tgtaagatgc tagtcatttt tatacatgag cccactgagg ccgagagaat     6720

caaggtcatg ctaaactcca ggtctcctga ctctgtgcag ttctctttgt agtgggctct     6780

gcaggtggag gtagaagggc ccgaacgtgt tcctggaatg gggctcccac cccctgcccc     6840

agggagctcc caggctatca ctgacttgtg tctcatgcgt cctcacaggg ggacagtgcc     6900

tgaaccgagg tccaagccgc atgtgccgct gccgtcctgg attcacgggc acctactgtg     6960

aactccacgt cagcgactgt gcccgtaacc cttgcgccca cggtggcact tgccatgacc     7020

tggagaatgg gctcatgtgc acctgccctg ccggcttctc tggccgacgc tgtgaggtgc     7080

ggacatccat cgatgcctgt gcctcgagtc cctgcttcaa cagggccacc tgctacaccg     7140

acctctccac agacaccttt gtgtgcaact gcccttatgg ctttgtgggc agccgctgcg     7200

agttccccgt gggcttgccg cccagcttcc cctgggtggc cgtctcgctg ggtgtggggc     7260

tggcagtgct gctggtactg ctgggcatgg tggcagtggc tgtgcggcag ctgcggcttc     7320

gacggccgga cgacggcagc agggaagcca tgaacaactt gtcggacttc cagaaggaca     7380

acctgattcc tgccgcccag cttaaaaaca caaaccagaa gaaggagctg gaagtggact     7440

gtggcctgga caagtccaac tgtggcaaac agcaaaacca cacattggac tataatctgg     7500

ccccagggcc cctggggcgg gggaccatgc caggaaagtt tccccacagt gacaagagct     7560

taggagagaa ggcgccactg cggttacaca ggtgagtggc acccagaagc ccagggcctg     7620

gccaccggcc ccgacatggt tctgcctagg ctcctcttag gccaggcggg aagcagttaa     7680

gcagctgagg ttttgttact gacaggaaga tcctccagta ggatttctgt caggggtcct     7740

ttgtccttcc ctcccattca ttcatttgtt cattcacaca tgtcaagtgt ccctagggtg     7800

tctcttgtga cttccgtctt tccacagtgt ggcttgcctc tagtggcagc actggcttta     7860

tgcagggctc agacccttct ggtgaggttg ggaggcctgt gactctctta ggggcctttt     7920

cctaagtgcc cccctgcagc agcccagcac tgggcacgtc cagcccctgt gtcttcccca     7980

agaaccaccc tgcagatgcc ctttggctct ccagggtcct ccctcccccc aagcctctcc     8040

ccgtccctcc cttacacgcc tgtcttgtgt tccctcagtg aaaagccaga gtgtcggata     8100

tcagcgatat gctcccccag ggactccatg taccagtctg tgtgtttgat atcagaggag     8160

aggaatgaat gtgtcattgc cacggaggtg agtgctgggc tcgcctttcc ttctgccttt     8220

tgtgggaggg aaagtggcct ggtcactctt gacccatggg ccattcctga agggtaggtc     8280

agaaccctgc cttggcaggc caagttcagt ggactcttgg gtccctgctg gcctcattgc     8340

cactaagggt gtgaaacagg aaccatggcg gcaagcctgg tctggtcctt tcctgctgta     8400

ttggtgctgg gttgggcagc cacggcactg ctggccagcc tctgatgggt gagggggccc     8460

ctcacccctt gtgcccttcc tgccccttcc cactggcttc ctccattgac ctcatgagcg     8520

caagctccca ggcccgtgtg tgtgttgggc cgaagactgg ggaggactgc cccacctgcc     8580

cttagcccct gcctgcccca tcgccttctc ccagggaggc ccagggaggg cctggaggga     8640

gtgcgcatgc ccagggtaac ctgtttccct gccttccgct tgctcccagg tataaggcag     8700

gagcctacct ggacatccct gctcagcccc gcggctggac cttccttctg cattgtttac     8760

attgcatcct ggatgggacg tttttcatat gcaacgtgct gctctcagga ggaggaggga     8820

atggcaggaa ccggacagac tgtgaacttg ccaagagatg caataccctt ccacaccttt     8880

gggtgtctgt ctggcatcag attggcagct gcaccaacca gaggaacaga agagaagaga     8940

gatgccactg ggcactgccc tgccagtagt ggccttcagg gggctccttc cggggctccg     9000

gcctgttttc cagagagagt ggcagtagcc ccatggggcc cggagctgct gtggcctcca     9060

ctggcatccg tgtttccaaa agtgcctttg gcccaggctc cacggcgaca gttgggccca     9120

aatcagaaag gagagagggg gccaatgagg gcagggcctc ctgtgggctg gaaaaccact     9180

gggtgcgtct cttgctgggg tttgccctgg aggtgaggtg agtgctcgag ggaggggagt     9240

gctttctgcc ccatgcctcc aactactgta tgcaggcctg gctctctggt ctaggccctt     9300

tgggcaagaa tgtccgtcta cccggcttcc accaccctct ggccctgggc ttctgtaagc     9360

agacaggcag agggcctgcc cctcccacca gccaagggtg ccaggcctaa ctggggcact     9420

cagggcagtg tgttggaaat tccactgagg gggaaatcag gtgctgcggc cgcctgggcc     9480

ctttcctccc tcaagcccat ctccacaacc tcgagcctgg gctctggtcc actactgccc     9540

cagaccaccc tcaaagctgg tcttcagaaa tcaataatat gagtttttat tttgtttttt     9600

tttttttttt tgtagtttat tttggagtct agtatttcaa taatttaaga atcagaagca     9660

ctgacctttc tacattttat aacattattt tgtatataat gtgtatttat aatatgaaac     9720

agatgtgtac agga                                                       9734


<210>  7
<211>  3426
<212>  DNA
<213>  Homo sapiens

<400>  7
agtagcggcg ctgcgcgcag gccgggaaca cgaggccaag agccgcagcc ccagccgcct       60

tggtgcagcg tacaccggca ctagcccgct tgcagcccca ggattagaca gaagacgcgt      120

cctcggcgcg gtcgccgccc agccgtagtc acctggatta cctacagcgg cagctgcagc      180

ggagccagcg agaaggccaa aggggagcag cgtcccgaga ggagcgcctc ttttcaggga      240

ccccgccggc tggcggacgc gcgggaaagc ggcgtcgcga acagagccag attgagggcc      300

cgcgggtgga gagagcgacg cccgagggga tggcggcagc gtcccggagc gcctctggct      360

gggcgctact gctgctggtg gcactttggc agcagcgcgc ggccggctcc ggcgtcttcc      420

agctgcagct gcaggagttc atcaacgagc gcggcgtact ggccagtggg cggccttgcg      480

agcccggctg ccggactttc ttccgcgtct gccttaagca cttccaggcg gtcgtctcgc      540

ccggaccctg caccttcggg accgtctcca cgccggtatt gggcaccaac tccttcgctg      600

tccgggacga cagtagcggc ggggggcgca accctctcca actgcccttc aatttcacct      660

ggccgggtac cttctcgctc atcatcgaag cttggcacgc gccaggagac gacctgcggc      720

cagaggcctt gccaccagat gcactcatca gcaagatcgc catccagggc tccctagctg      780

tgggtcagaa ctggttattg gatgagcaaa ccagcaccct cacaaggctg cgctactctt      840

accgggtcat ctgcagtgac aactactatg gagacaactg ctcccgcctg tgcaagaagc      900

gcaatgacca cttcggccac tatgtgtgcc agccagatgg caacttgtcc tgcctgcccg      960

gttggactgg ggaatattgc caacagccta tctgtctttc gggctgtcat gaacagaatg     1020

gctactgcag caagccagca gagtgcctct gccgcccagg ctggcagggc cggctgtgta     1080

acgaatgcat cccccacaat ggctgtcgcc acggcacctg cagcactccc tggcaatgta     1140

cttgtgatga gggctgggga ggcctgtttt gtgaccaaga tctcaactac tgcacccacc     1200

actccccatg caagaatggg gcaacgtgct ccaacagtgg gcagcgaagc tacacctgca     1260

cctgtcgccc aggctacact ggtgtggact gtgagctgga gctcagcgag tgtgacagca     1320

acccctgtcg caatggaggc agctgtaagg accaggagga tggctaccac tgcctgtgtc     1380

ctccgggcta ctatggcctg cattgtgaac acagcacctt gagctgcgcc gactccccct     1440

gcttcaatgg gggctcctgc cgggagcgca accagggggc caactatgct tgtgaatgtc     1500

cccccaactt caccggctcc aactgcgaga agaaagtgga caggtgcacc agcaacccct     1560

gtgccaacgg gggacagtgc ctgaaccgag gtccaagccg catgtgccgc tgccgtcctg     1620

gattcacggg cacctactgt gaactccacg tcagcgactg tgcccgtaac ccttgcgccc     1680

acggtggcac ttgccatgac ctggagaatg ggctcatgtg cacctgccct gccggcttct     1740

ctggccgacg ctgtgaggtg cggacatcca tcgatgcctg tgcctcgagt ccctgcttca     1800

acagggccac ctgctacacc gacctctcca cagacacctt tgtgtgcaac tgcccttatg     1860

gctttgtggg cagccgctgc gagttccccg tgggcttgcc gcccagcttc ccctgggtgg     1920

ccgtctcgct gggtgtgggg ctggcagtgc tgctggtact gctgggcatg gtggcagtgg     1980

ctgtgcggca gctgcggctt cgacggccgg acgacggcag cagggaagcc atgaacaact     2040

tgtcggactt ccagaaggac aacctgattc ctgccgccca gcttaaaaac acaaaccaga     2100

agaaggagct ggaagtggac tgtggcctgg acaagtccaa ctgtggcaaa cagcaaaacc     2160

acacattgga ctataatctg gccccagggc ccctggggcg ggggaccatg ccaggaaagt     2220

ttccccacag tgacaagagc ttaggagaga aggcgccact gcggttacac agtgaaaagc     2280

cagagtgtcg gatatcagcg atatgctccc ccagggactc catgtaccag tctgtgtgtt     2340

tgatatcaga ggagaggaat gaatgtgtca ttgccacgga ggtataaggc aggagcctac     2400

ctggacatcc ctgctcagcc ccgcggctgg accttccttc tgcattgttt acattgcatc     2460

ctggatggga cgtttttcat atgcaacgtg ctgctctcag gaggaggagg gaatggcagg     2520

aaccggacag actgtgaact tgccaagaga tgcaataccc ttccacacct ttgggtgtct     2580

gtctggcatc agattggcag ctgcaccaac cagaggaaca gaagagaaga gagatgccac     2640

tgggcactgc cctgccagta gtggccttca gggggctcct tccggggctc cggcctgttt     2700

tccagagaga gtggcagtag ccccatgggg cccggagctg ctgtggcctc cactggcatc     2760

cgtgtttcca aaagtgcctt tggcccaggc tccacggcga cagttgggcc caaatcagaa     2820

aggagagagg gggccaatga gggcagggcc tcctgtgggc tggaaaacca ctgggtgcgt     2880

ctcttgctgg ggtttgccct ggaggtgagg tgagtgctcg agggagggga gtgctttctg     2940

ccccatgcct ccaactactg tatgcaggcc tggctctctg gtctaggccc tttgggcaag     3000

aatgtccgtc tacccggctt ccaccaccct ctggccctgg gcttctgtaa gcagacaggc     3060

agagggcctg cccctcccac cagccaaggg tgccaggcct aactggggca ctcagggcag     3120

tgtgttggaa attccactga gggggaaatc aggtgctgcg gccgcctggg ccctttcctc     3180

cctcaagccc atctccacaa cctcgagcct gggctctggt ccactactgc cccagaccac     3240

cctcaaagct ggtcttcaga aatcaataat atgagttttt attttgtttt tttttttttt     3300

tttgtagttt attttggagt ctagtatttc aataatttaa gaatcagaag cactgacctt     3360

tctacatttt ataacattat tttgtatata atgtgtattt ataatatgaa acagatgtgt     3420

acagga                                                                3426


<210>  8
<211>  2058
<212>  DNA
<213>  Homo sapiens

<400>  8
atggcggcag cgtcccggag cgcctctggc tgggcgctac tgctgctggt ggcactttgg       60

cagcagcgcg cggccggctc cggcgtcttc cagctgcagc tgcaggagtt catcaacgag      120

cgcggcgtac tggccagtgg gcggccttgc gagcccggct gccggacttt cttccgcgtc      180

tgccttaagc acttccaggc ggtcgtctcg cccggaccct gcaccttcgg gaccgtctcc      240

acgccggtat tgggcaccaa ctccttcgct gtccgggacg acagtagcgg cggggggcgc      300

aaccctctcc aactgccctt caatttcacc tggccgggta ccttctcgct catcatcgaa      360

gcttggcacg cgccaggaga cgacctgcgg ccagaggcct tgccaccaga tgcactcatc      420

agcaagatcg ccatccaggg ctccctagct gtgggtcaga actggttatt ggatgagcaa      480

accagcaccc tcacaaggct gcgctactct taccgggtca tctgcagtga caactactat      540

ggagacaact gctcccgcct gtgcaagaag cgcaatgacc acttcggcca ctatgtgtgc      600

cagccagatg gcaacttgtc ctgcctgccc ggttggactg gggaatattg ccaacagcct      660

atctgtcttt cgggctgtca tgaacagaat ggctactgca gcaagccagc agagtgcctc      720

tgccgcccag gctggcaggg ccggctgtgt aacgaatgca tcccccacaa tggctgtcgc      780

cacggcacct gcagcactcc ctggcaatgt acttgtgatg agggctgggg aggcctgttt      840

tgtgaccaag atctcaacta ctgcacccac cactccccat gcaagaatgg ggcaacgtgc      900

tccaacagtg ggcagcgaag ctacacctgc acctgtcgcc caggctacac tggtgtggac      960

tgtgagctgg agctcagcga gtgtgacagc aacccctgtc gcaatggagg cagctgtaag     1020

gaccaggagg atggctacca ctgcctgtgt cctccgggct actatggcct gcattgtgaa     1080

cacagcacct tgagctgcgc cgactccccc tgcttcaatg ggggctcctg ccgggagcgc     1140

aaccaggggg ccaactatgc ttgtgaatgt ccccccaact tcaccggctc caactgcgag     1200

aagaaagtgg acaggtgcac cagcaacccc tgtgccaacg ggggacagtg cctgaaccga     1260

ggtccaagcc gcatgtgccg ctgccgtcct ggattcacgg gcacctactg tgaactccac     1320

gtcagcgact gtgcccgtaa cccttgcgcc cacggtggca cttgccatga cctggagaat     1380

gggctcatgt gcacctgccc tgccggcttc tctggccgac gctgtgaggt gcggacatcc     1440

atcgatgcct gtgcctcgag tccctgcttc aacagggcca cctgctacac cgacctctcc     1500

acagacacct ttgtgtgcaa ctgcccttat ggctttgtgg gcagccgctg cgagttcccc     1560

gtgggcttgc cgcccagctt cccctgggtg gccgtctcgc tgggtgtggg gctggcagtg     1620

ctgctggtac tgctgggcat ggtggcagtg gctgtgcggc agctgcggct tcgacggccg     1680

gacgacggca gcagggaagc catgaacaac ttgtcggact tccagaagga caacctgatt     1740

cctgccgccc agcttaaaaa cacaaaccag aagaaggagc tggaagtgga ctgtggcctg     1800

gacaagtcca actgtggcaa acagcaaaac cacacattgg actataatct ggccccaggg     1860

cccctggggc gggggaccat gccaggaaag tttccccaca gtgacaagag cttaggagag     1920

aaggcgccac tgcggttaca cagtgaaaag ccagagtgtc ggatatcagc gatatgctcc     1980

cccagggact ccatgtacca gtctgtgtgt ttgatatcag aggagaggaa tgaatgtgtc     2040

attgccacgg aggtataa                                                   2058


<210>  9
<211>  685
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Ala Ala Ser Arg Ser Ala Ser Gly Trp Ala Leu Leu Leu Leu 
1               5                   10                  15      


Val Ala Leu Trp Gln Gln Arg Ala Ala Gly Ser Gly Val Phe Gln Leu 
            20                  25                  30          


Gln Leu Gln Glu Phe Ile Asn Glu Arg Gly Val Leu Ala Ser Gly Arg 
        35                  40                  45              


Pro Cys Glu Pro Gly Cys Arg Thr Phe Phe Arg Val Cys Leu Lys His 
    50                  55                  60                  


Phe Gln Ala Val Val Ser Pro Gly Pro Cys Thr Phe Gly Thr Val Ser 
65                  70                  75                  80  


Thr Pro Val Leu Gly Thr Asn Ser Phe Ala Val Arg Asp Asp Ser Ser 
                85                  90                  95      


Gly Gly Gly Arg Asn Pro Leu Gln Leu Pro Phe Asn Phe Thr Trp Pro 
            100                 105                 110         


Gly Thr Phe Ser Leu Ile Ile Glu Ala Trp His Ala Pro Gly Asp Asp 
        115                 120                 125             


Leu Arg Pro Glu Ala Leu Pro Pro Asp Ala Leu Ile Ser Lys Ile Ala 
    130                 135                 140                 


Ile Gln Gly Ser Leu Ala Val Gly Gln Asn Trp Leu Leu Asp Glu Gln 
145                 150                 155                 160 


Thr Ser Thr Leu Thr Arg Leu Arg Tyr Ser Tyr Arg Val Ile Cys Ser 
                165                 170                 175     


Asp Asn Tyr Tyr Gly Asp Asn Cys Ser Arg Leu Cys Lys Lys Arg Asn 
            180                 185                 190         


Asp His Phe Gly His Tyr Val Cys Gln Pro Asp Gly Asn Leu Ser Cys 
        195                 200                 205             


Leu Pro Gly Trp Thr Gly Glu Tyr Cys Gln Gln Pro Ile Cys Leu Ser 
    210                 215                 220                 


Gly Cys His Glu Gln Asn Gly Tyr Cys Ser Lys Pro Ala Glu Cys Leu 
225                 230                 235                 240 


Cys Arg Pro Gly Trp Gln Gly Arg Leu Cys Asn Glu Cys Ile Pro His 
                245                 250                 255     


Asn Gly Cys Arg His Gly Thr Cys Ser Thr Pro Trp Gln Cys Thr Cys 
            260                 265                 270         


Asp Glu Gly Trp Gly Gly Leu Phe Cys Asp Gln Asp Leu Asn Tyr Cys 
        275                 280                 285             


Thr His His Ser Pro Cys Lys Asn Gly Ala Thr Cys Ser Asn Ser Gly 
    290                 295                 300                 


Gln Arg Ser Tyr Thr Cys Thr Cys Arg Pro Gly Tyr Thr Gly Val Asp 
305                 310                 315                 320 


Cys Glu Leu Glu Leu Ser Glu Cys Asp Ser Asn Pro Cys Arg Asn Gly 
                325                 330                 335     


Gly Ser Cys Lys Asp Gln Glu Asp Gly Tyr His Cys Leu Cys Pro Pro 
            340                 345                 350         


Gly Tyr Tyr Gly Leu His Cys Glu His Ser Thr Leu Ser Cys Ala Asp 
        355                 360                 365             


Ser Pro Cys Phe Asn Gly Gly Ser Cys Arg Glu Arg Asn Gln Gly Ala 
    370                 375                 380                 


Asn Tyr Ala Cys Glu Cys Pro Pro Asn Phe Thr Gly Ser Asn Cys Glu 
385                 390                 395                 400 


Lys Lys Val Asp Arg Cys Thr Ser Asn Pro Cys Ala Asn Gly Gly Gln 
                405                 410                 415     


Cys Leu Asn Arg Gly Pro Ser Arg Met Cys Arg Cys Arg Pro Gly Phe 
            420                 425                 430         


Thr Gly Thr Tyr Cys Glu Leu His Val Ser Asp Cys Ala Arg Asn Pro 
        435                 440                 445             


Cys Ala His Gly Gly Thr Cys His Asp Leu Glu Asn Gly Leu Met Cys 
    450                 455                 460                 


Thr Cys Pro Ala Gly Phe Ser Gly Arg Arg Cys Glu Val Arg Thr Ser 
465                 470                 475                 480 


Ile Asp Ala Cys Ala Ser Ser Pro Cys Phe Asn Arg Ala Thr Cys Tyr 
                485                 490                 495     


Thr Asp Leu Ser Thr Asp Thr Phe Val Cys Asn Cys Pro Tyr Gly Phe 
            500                 505                 510         


Val Gly Ser Arg Cys Glu Phe Pro Val Gly Leu Pro Pro Ser Phe Pro 
        515                 520                 525             


Trp Val Ala Val Ser Leu Gly Val Gly Leu Ala Val Leu Leu Val Leu 
    530                 535                 540                 


Leu Gly Met Val Ala Val Ala Val Arg Gln Leu Arg Leu Arg Arg Pro 
545                 550                 555                 560 


Asp Asp Gly Ser Arg Glu Ala Met Asn Asn Leu Ser Asp Phe Gln Lys 
                565                 570                 575     


Asp Asn Leu Ile Pro Ala Ala Gln Leu Lys Asn Thr Asn Gln Lys Lys 
            580                 585                 590         


Glu Leu Glu Val Asp Cys Gly Leu Asp Lys Ser Asn Cys Gly Lys Gln 
        595                 600                 605             


Gln Asn His Thr Leu Asp Tyr Asn Leu Ala Pro Gly Pro Leu Gly Arg 
    610                 615                 620                 


Gly Thr Met Pro Gly Lys Phe Pro His Ser Asp Lys Ser Leu Gly Glu 
625                 630                 635                 640 


Lys Ala Pro Leu Arg Leu His Ser Glu Lys Pro Glu Cys Arg Ile Ser 
                645                 650                 655     


Ala Ile Cys Ser Pro Arg Asp Ser Met Tyr Gln Ser Val Cys Leu Ile 
            660                 665                 670         


Ser Glu Glu Arg Asn Glu Cys Val Ile Ala Thr Glu Val 
        675                 680                 685 


<210>  10
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  10

Met Ala Ala Ala Ser Arg Ser Ala Ser Gly Trp Ala Leu Leu Leu Leu 
1               5                   10                  15      


Val Ala Leu Trp Gln Gln Arg Ala Ala Gly Ser Gly Val Phe Gln Leu 
            20                  25                  30          


Gln Leu Gln Glu Phe Ile Asn Glu Arg Gly Val Leu Ala Ser Gly Arg 
        35                  40                  45              


Pro Cys Glu Pro Gly Cys Arg Thr Phe Phe Arg Val Cys Leu Lys His 
    50                  55                  60                  


Phe Gln Ala Val Val Ser Pro Gly Pro Cys Thr Phe Gly Thr Val Ser 
65                  70                  75                  80  


Thr Pro Val Leu Gly Thr Asn Ser Phe Ala Val Arg Asp Asp Ser Ser 
                85                  90                  95      


Gly Gly Gly Arg Asn Pro Leu Gln Leu Pro Phe Asn Phe Thr Trp Pro 
            100                 105                 110         


Gly Thr Phe Ser Leu Ile Ile Glu Ala Trp His Ala Pro Gly Asp Asp 
        115                 120                 125             


Leu Arg Pro Glu Ala Leu Pro Pro Asp Ala Leu Ile Ser Lys Ile Ala 
    130                 135                 140                 


Ile Gln Gly Ser Leu Ala Val Gly Gln Asn Trp Leu Leu Asp Glu Gln 
145                 150                 155                 160 


Thr Ser Thr Leu Thr Arg Leu Arg Tyr Ser Tyr Arg Val Ile Cys Ser 
                165                 170                 175     


Asp Asn Tyr Tyr Gly Asp Asn Cys Ser Arg Leu Cys Lys Lys Arg Asn 
            180                 185                 190         


Asp His Phe Gly His Tyr Val Cys Gln Pro Asp Gly Asn Leu Ser Cys 
        195                 200                 205             


Leu Pro Gly Trp Thr Gly Glu Tyr Cys Gln Gln Pro Ile Cys Leu Ser 
    210                 215                 220                 


Gly Cys His Glu Gln Asn Gly Tyr Cys Ser Lys Pro Ala Glu Cys Leu 
225                 230                 235                 240 


Cys Arg Pro Gly Trp Gln Gly Arg Leu Cys Asn Glu Cys Ile Pro His 
                245                 250                 255     


Asn Gly Cys Arg His Gly Thr Cys Ser Thr Pro Trp Gln Cys Thr Cys 
            260                 265                 270         


Asp Glu Gly Trp Gly Gly Leu Phe Cys Asp Gln Asp Leu Asn Tyr Cys 
        275                 280                 285             


Thr His His Ser Pro Cys Lys Asn Gly Ala Thr Cys Ser Asn Ser Gly 
    290                 295                 300                 


Gln Arg Ser Tyr Thr Cys Thr Cys Arg Pro Gly Tyr Thr Gly Val Asp 
305                 310                 315                 320 


Cys Glu Leu Glu Leu Ser Glu Cys Asp Ser Asn Pro Cys Arg Asn Gly 
                325                 330                 335     


Gly Ser Cys Lys Asp Gln Glu Asp Gly Tyr His Cys Leu Cys Pro Pro 
            340                 345                 350         


Gly Tyr Tyr Gly Leu His Cys Glu His Ser Thr Leu Ser Cys Ala Asp 
        355                 360                 365             


Ser Pro Cys Phe Asn Gly Gly Ser Cys Arg Glu Arg Asn Gln Gly Ala 
    370                 375                 380                 


Asn Tyr Ala Cys Glu Cys Pro Pro Asn Phe Thr Gly Ser Asn Cys Glu 
385                 390                 395                 400 


Lys Lys Val Asp Arg Cys Thr Ser Asn Pro Cys Ala Asn Gly Gly Gln 
                405                 410                 415     


Cys Leu Asn Arg Gly Pro Ser Arg Met Cys Arg Cys Arg Pro Gly Phe 
            420                 425                 430         


Thr Gly Thr Tyr Cys Glu Leu His Val Ser Asp Cys Ala Arg Asn Pro 
        435                 440                 445             


Cys Ala His Gly Gly Thr Cys His Asp Leu Glu Asn Gly Leu Met Cys 
    450                 455                 460                 


Thr Cys Pro Ala Gly Phe Ser Gly Arg Arg Cys Glu Val Arg Thr Ser 
465                 470                 475                 480 


Ile Asp Ala Cys Ala Ser Ser Pro Cys Phe Asn Arg Ala Thr Cys Tyr 
                485                 490                 495     


Thr Asp Leu Ser Thr Asp Thr Phe Val Cys Asn Cys Pro Tyr Gly Phe 
            500                 505                 510         


Val Gly Ser Arg Cys Glu Phe Pro Val Gly Leu Pro Pro Ser 
        515                 520                 525     


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  11
ctatctggca gtgcgagaat g                                                 21


<210>  12
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  12
agacgtgcaa gcaggtcttt c                                                 21


<210>  13
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  13
tggatgactt atgcgtgatt t                                                 21


<210>  14
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  14
caacagaact ttatggtaga a                                                 21


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  15
ccgccgtggt ttgtattcat t                                                 21


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  16
gcttcctctt caacctcaat a                                                 21


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  17
ccgccgtggt ttgtattcat t                                                 21


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  18
gctcttcttt gattacaggt a                                                 21


<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  19
gctactcgga aaggaaacaa a                                                 21


<210>  20
<211>  128
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  20
attacagcaa gatggaaata ccaaatcccc ctacctccaa atgtatcact tactggaaaa       60

gaaaagtgaa atctgaatac atgcgacttc gacaacttaa acggcttcag gcaaatatgg      120

gtgcaaag                                                               128


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  21
tcgacaactt aaacggcttc                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  22
tgcgacttcg acaacttaaa                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  23
cctccaaatg tatcacttac                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  24
taaacggctt caggcaaata                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  25
aaacggcttc aggcaaatat                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  26
catttggagg tagggggatt                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  27
ccagtaagtg atacatttgg                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  28
gtgatacatt tggaggtagg                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  29
aagtgataca tttggaggta                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  30
agtgatacat ttggaggtag                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  31
tttccagtaa gtgatacatt                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  32
taagtgatac atttggaggt                                                   20


<210>  33
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  33
gctttgtatg tggcaaattt tgcaaaggtt caagaaaaaa cccagatcct caatgaagaa       60

tggaagaagc ttcgtgtcca acctgttcag tcaatgaagc ctgtgagtgg acaccctttt      120

ctcaaaaag                                                              129


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  34
gcttcattga ctgaacaggt                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  35
acaggcttca ttgactgaac                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  36
agaaaagggt gtccactcac                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  37
tccattcttc attgaggatc                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  38
ccattcttca ttgaggatct                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  39
cccagatcct caatgaagaa                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  40
gtatgtggca aattttgcaa                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  41
cagtcaatga agcctgtgag                                                   20


<210>  42
<211>  754
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  42

Ser Gly Val Phe Glu Leu Lys Leu Gln Glu Phe Val Asn Lys Lys Gly 
1               5                   10                  15      


Leu Leu Gly Asn Arg Asn Cys Cys Arg Gly Gly Ala Gly Pro Pro Pro 
            20                  25                  30          


Cys Ala Cys Arg Thr Phe Phe Arg Val Cys Leu Lys His Tyr Gln Ala 
        35                  40                  45              


Ser Val Ser Pro Glu Pro Pro Cys Thr Tyr Gly Ser Ala Val Thr Pro 
    50                  55                  60                  


Val Leu Gly Val Asp Ser Phe Ser Leu Pro Asp Gly Gly Gly Ala Asp 
65                  70                  75                  80  


Ser Ala Phe Ser Asn Pro Ile Arg Phe Pro Phe Gly Phe Thr Trp Pro 
                85                  90                  95      


Gly Thr Phe Ser Leu Ile Ile Glu Ala Leu His Thr Asp Ser Pro Asp 
            100                 105                 110         


Asp Leu Ala Thr Glu Asn Pro Glu Arg Leu Ile Ser Arg Leu Ala Thr 
        115                 120                 125             


Gln Arg His Leu Thr Val Gly Glu Glu Trp Ser Gln Asp Leu His Ser 
    130                 135                 140                 


Ser Gly Arg Thr Asp Leu Lys Tyr Ser Tyr Arg Phe Val Cys Asp Glu 
145                 150                 155                 160 


His Tyr Tyr Gly Glu Gly Cys Ser Val Phe Cys Arg Pro Arg Asp Asp 
                165                 170                 175     


Ala Phe Gly His Phe Thr Cys Gly Glu Arg Gly Glu Lys Val Cys Asn 
            180                 185                 190         


Pro Gly Trp Lys Gly Pro Tyr Cys Thr Glu Pro Ile Cys Leu Pro Gly 
        195                 200                 205             


Cys Asp Glu Gln His Gly Phe Cys Asp Lys Pro Gly Glu Cys Lys Cys 
    210                 215                 220                 


Arg Val Gly Trp Gln Gly Arg Tyr Cys Asp Glu Cys Ile Arg Tyr Pro 
225                 230                 235                 240 


Gly Cys Leu His Gly Thr Cys Gln Gln Pro Trp Gln Cys Asn Cys Gln 
                245                 250                 255     


Glu Gly Trp Gly Gly Leu Phe Cys Asn Gln Asp Leu Asn Tyr Cys Thr 
            260                 265                 270         


His His Lys Pro Cys Lys Asn Gly Ala Thr Cys Thr Asn Thr Gly Gln 
        275                 280                 285             


Gly Ser Tyr Thr Cys Ser Cys Arg Pro Gly Tyr Thr Gly Ala Thr Cys 
    290                 295                 300                 


Glu Leu Gly Ile Asp Glu Cys Asp Pro Ser Pro Cys Lys Asn Gly Gly 
305                 310                 315                 320 


Ser Cys Thr Asp Leu Glu Asn Ser Tyr Ser Cys Thr Cys Pro Pro Gly 
                325                 330                 335     


Phe Tyr Gly Lys Ile Cys Glu Leu Ser Ala Met Thr Cys Ala Asp Gly 
            340                 345                 350         


Pro Cys Phe Asn Gly Gly Arg Cys Ser Asp Ser Pro Asp Gly Gly Tyr 
        355                 360                 365             


Ser Cys Arg Cys Pro Val Gly Tyr Ser Gly Phe Asn Cys Glu Lys Lys 
    370                 375                 380                 


Ile Asp Tyr Cys Ser Ser Ser Pro Cys Ser Asn Gly Ala Lys Cys Val 
385                 390                 395                 400 


Asp Leu Gly Asp Ala Tyr Leu Cys Arg Cys Gln Ala Gly Phe Ser Gly 
                405                 410                 415     


Arg His Cys Asp Asp Asn Val Asp Asp Cys Ala Ser Ser Pro Cys Ala 
            420                 425                 430         


Asn Gly Gly Thr Cys Arg Asp Gly Val Asn Asp Phe Ser Cys Thr Cys 
        435                 440                 445             


Pro Pro Gly Tyr Thr Gly Arg Asn Cys Ser Ala Pro Val Ser Arg Cys 
    450                 455                 460                 


Glu His Ala Pro Cys His Asn Gly Ala Thr Cys His Glu Arg Gly His 
465                 470                 475                 480 


Arg Tyr Val Cys Glu Cys Ala Arg Gly Tyr Gly Gly Pro Asn Cys Gln 
                485                 490                 495     


Phe Leu Leu Pro Glu Leu Pro Pro Gly Pro Ala Val Val Asp Leu Thr 
            500                 505                 510         


Glu Lys Leu Glu Ile Glu Gly Arg Met Asp Pro Pro Lys Ser Cys Asp 
        515                 520                 525             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    530                 535                 540                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
545                 550                 555                 560 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                565                 570                 575     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            580                 585                 590         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        595                 600                 605             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    610                 615                 620                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
625                 630                 635                 640 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                645                 650                 655     


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
            660                 665                 670         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        675                 680                 685             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    690                 695                 700                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
705                 710                 715                 720 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                725                 730                 735     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            740                 745                 750         


Gly Lys 
        


<210>  43
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  43

Ser Gly Val Phe Gln Leu Gln Leu Gln Glu Phe Ile Asn Glu Arg Gly 
1               5                   10                  15      


Val Leu Ala Ser Gly Arg Pro Cys Glu Pro Gly Cys Arg Thr Phe Phe 
            20                  25                  30          


Arg Val Cys Leu Lys His Phe Gln Ala Val Val Ser Pro Gly Pro Cys 
        35                  40                  45              


Thr Phe Gly Thr Val Ser Thr Pro Val Leu Gly Thr Asn Ser Phe Ala 
    50                  55                  60                  


Val Arg Asp Asp Ser Ser Gly Gly Gly Arg Asn Pro Leu Gln Leu Pro 
65                  70                  75                  80  


Phe Asn Phe Thr Trp Pro Gly Thr Phe Ser Leu Ile Ile Glu Ala Trp 
                85                  90                  95      


His Ala Pro Gly Asp Asp Leu Arg Pro Glu Ala Leu Pro Pro Asp Ala 
            100                 105                 110         


Leu Ile Ser Lys Ile Ala Ile Gln Gly Ser Leu Ala Val Gly Gln Asn 
        115                 120                 125             


Trp Leu Leu Asp Glu Gln Thr Ser Thr Leu Thr Arg Leu Arg Tyr Ser 
    130                 135                 140                 


Tyr Arg Val Ile Cys Ser Asp Asn Tyr Tyr Gly Asp Asn Cys Ser Arg 
145                 150                 155                 160 


Leu Cys Lys Lys Arg Asn Asp His Phe Gly His Tyr Val Cys Gln Pro 
                165                 170                 175     


Asp Gly Asn Leu Ser Cys Leu Pro Gly Trp Thr Gly Glu Tyr Cys Gln 
            180                 185                 190         


Gln Pro Ile Cys Leu Ser Gly Cys His Glu Gln Asn Gly Tyr Cys Ser 
        195                 200                 205             


Lys Pro Ala Glu Cys Leu Cys Arg Pro Gly Trp Gln Gly Arg Leu Cys 
    210                 215                 220                 


Asn Glu Cys Ile Pro His Asn Gly Cys Arg His Gly Thr Cys Ser Thr 
225                 230                 235                 240 


Pro Trp Gln Cys Thr Cys Asp Glu Gly Trp Gly Gly Leu Phe Cys Asp 
                245                 250                 255     


Gln Asp Leu Asn Tyr Cys Thr His His Ser Pro Cys Lys Asn Gly Ala 
            260                 265                 270         


Thr Cys Ser Asn Ser Gly Gln Arg Ser Tyr Thr Cys Thr Cys Arg Pro 
        275                 280                 285             


Gly Tyr Thr Gly Val Asp Cys Glu Leu Glu Leu Ser Glu Cys Asp Ser 
    290                 295                 300                 


Asn Pro Cys Arg Asn Gly Gly Ser Cys Lys Asp Gln Glu Asp Gly Tyr 
305                 310                 315                 320 


His Cys Leu Cys Pro Pro Gly Tyr Tyr Gly Leu His Cys Glu His Ser 
                325                 330                 335     


Thr Leu Ser Cys Ala Asp Ser Pro Cys Phe Asn Gly Gly Ser Cys Arg 
            340                 345                 350         


Glu Arg Asn Gln Gly Ala Asn Tyr Ala Cys Glu Cys Pro Pro Asn Phe 
        355                 360                 365             


Thr Gly Ser Asn Cys Glu Lys Lys Val Asp Arg Cys Thr Ser Asn Pro 
    370                 375                 380                 


Cys Ala Asn Gly Gly Gln Cys Leu Asn Arg Gly Pro Ser Arg Met Cys 
385                 390                 395                 400 


Arg Cys Arg Pro Gly Phe Thr Gly Thr Tyr Cys Glu Leu His Val Ser 
                405                 410                 415     


Asp Cys Ala Arg Asn Pro Cys Ala His Gly Gly Thr Cys His Asp Leu 
            420                 425                 430         


Glu Asn Gly Leu Met Cys Thr Cys Pro Ala Gly Phe Ser Gly Arg Arg 
        435                 440                 445             


Cys Glu Val Arg Thr Ser Ile Asp Ala Cys Ala Ser Ser Pro Cys Phe 
    450                 455                 460                 


Asn Arg Ala Thr Cys Tyr Thr Asp Leu Ser Thr Asp Thr Phe Val Cys 
465                 470                 475                 480 


Asn Cys Pro Tyr Gly Phe Val Gly Ser Arg Cys Glu Phe Pro Val Gly 
                485                 490                 495     


Leu Pro Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
            500                 505                 510         


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        515                 520                 525             


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    530                 535                 540                 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
545                 550                 555                 560 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                565                 570                 575     


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
            580                 585                 590         


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
        595                 600                 605             


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
    610                 615                 620                 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
625                 630                 635                 640 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                645                 650                 655     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            660                 665                 670         


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        675                 680                 685             


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    690                 695                 700                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
705                 710                 715                 720 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                725                 


<210>  44
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  44

Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
1               5                   10                  15      


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys 
225                 230     


<210>  45
<211>  3702
<212>  DNA
<213>  Homo sapiens

<400>  45
atgcggggtc taccgagagg gagggggttg atgcgggccc gggggagggg tcgtgcggcc       60

cctccgggca gccgaggccg cggaaggggg gggccccaca gaggaagagg taggccccgg      120

agcctactct ctcttcccag ggcccaggca tcctggaccc cccaactctc tactgggctg      180

accagccctc ctgtcccttg tctcccctcc cagggggagg cccccgctga gatgggggcg      240

ctgctgctgg agaaggaaac cagaggagcc accgagagag ttcatggctc tttgggggac      300

acccctcgta gtgaagaaac cctgcccaag gccacccccg actccctgga gcctgctggc      360

ccctcatctc cagcctctgt cactgtcact gttggtgatg agggggctga cacccctgta      420

ggggctacac cactcattgg ggatgaatct gagaatcttg agggagatgg ggacctccgt      480

gggggccgga tcctgctggg ccatgccaca aagtcattcc cctcttcccc cagcaagggg      540

ggttcctgtc ctagccgggc caagatgtca atgacagggg cgggaaaatc acctccatct      600

gtccagagtt tggctatgag gctactgagt atgccaggag cccagggagc tgcagcagca      660

gggtctgaac cccctccagc caccacgagc ccagagggac agcccaaggt ccaccgagcc      720

cgcaaaacca tgtccaaacc aggaaatgga cagcccccgg tccctgagaa gcggccccct      780

gaaatacagc atttccgcat gagtgatgat gtccactcac tgggaaaggt gacctcagat      840

ctggccaaaa ggaggaagct gaactcagga ggtggcctgt cagaggagtt aggttctgcc      900

cggcgttcag gagaagtgac cctgacgaaa ggggaccccg ggtccctgga ggagtgggag      960

acggtggtgg gtgatgactt cagtctctac tatgattcct actctgtgga tgagcgcgtg     1020

gactccgaca gcaagtctga agttgaagct ctaactgaac aactaagtga agaggaggag     1080

gaggaagagg aggaagaaga agaagaggaa gaggaggagg aagaggaaga agaagaggaa     1140

gatgaggagt cagggaatca gtcagatagg agtggttcca gtggccggcg caaggccaag     1200

aagaaatggc gaaaagacag cccatgggtg aagccgtctc ggaaacggcg caagcgggag     1260

cctccgcggg ccaaggagcc acgaggggtg tccaatgaca catcttcgct ggagacagag     1320

cgagggtttg aggagttgcc cctgtgcagc tgccgcatgg aggcacccaa gattgaccgc     1380

atcagcgaga gggcggggca caagtgcatg gccactgaga gtgtggacgg agagctgtca     1440

ggctgcaatg ccgccatcct caagcgggag accatgaggc catccagccg tgtggccctg     1500

atggtgctct gtgagaccca ccgcgcccgc atggtcaaac accactgctg cccgggctgc     1560

ggctacttct gcacggcggg caccttcctg gagtgccacc ctgacttccg tgtggcccac     1620

cgcttccaca aggcctgtgt gtctcagctg aatgggatgg tcttctgtcc ccactgtggg     1680

gaggatgctt ctgaagctca agaggtgacc atcccccggg gtgacggggt gaccccaccg     1740

gccggcactg cagctcctgc acccccaccc ctgtcccagg atgtccccgg gagagcagac     1800

acttctcagc ccagtgcccg gatgcgaggg catggggaac cccggcgccc gccctgcgat     1860

cccctggctg acaccattga cagctcaggg ccctccctga ccctgcccaa tgggggctgc     1920

ctttcagccg tggggctgcc actggggcca ggccgggagg ccctggaaaa ggccctggtc     1980

atccaggagt cagagaggcg gaagaagctc cgtttccacc ctcggcagtt gtacctgtcc     2040

gtgaagcagg gcgagctgca gaaggtgatc ctgatgctgt tggacaacct ggaccccaac     2100

ttccagagcg accagcagag caagcgcacg cccctgcatg cagccgccca gaagggctcc     2160

gtggagatct gccatgtgct gctgcaggct ggagccaaca taaatgcagt ggacaaacag     2220

cagcggacgc cactgatgga ggccgtggtg aacaaccacc tggaggtagc ccgttacatg     2280

gtgcagcgtg gtggctgtgt ctatagcaag gaggaggacg gttccacctg cctccaccac     2340

gcagccaaaa tcgggaactt ggagatggtc agcctgctgc tgagcacagg acaggtggac     2400

gtcaacgccc aggacagtgg ggggtggacg cccatcatct gggctgcaga gcacaagcac     2460

atcgaggtga tccgcatgct actgacgcgg ggcgccgacg tcaccctcac tgacaacgag     2520

gagaacatct gcctgcactg ggcctccttc acgggcagcg ccgccatcgc cgaagtcctt     2580

ctgaatgcgc gctgtgacct ccatgctgtc aactaccatg gggacacccc cctgcacatc     2640

gcagctcggg agagctacca tgactgcgtg ctgttattcc tgtcacgtgg ggccaaccct     2700

gagctgcgga acaaagaggg ggacacagca tgggacctga ctcccgagcg ctccgacgtg     2760

tggtttgcgc ttcaactcaa ccgcaagctc cgacttgggg tgggaaatcg ggccatccgc     2820

acagagaaga tcatctgccg ggacgtggct cggggctatg agaacgtgcc cattccctgt     2880

gtcaacggtg tggatgggga gccctgccct gaggattaca agtacatctc agagaactgc     2940

gagacgtcca ccatgaacat cgatcgcaac atcacccacc tgcagcactg cacgtgtgtg     3000

gacgactgct ctagctccaa ctgcctgtgc ggccagctca gcatccggtg ctggtatgac     3060

aaggatgggc gattgctcca ggaatttaac aagattgagc ctccgctgat tttcgagtgt     3120

aaccaggcgt gctcatgctg gagaaactgc aagaaccggg tcgtacagag tggcatcaag     3180

gtgcggctac agctctaccg aacagccaag atgggctggg gggtccgcgc cctgcagacc     3240

atcccacagg ggaccttcat ctgcgagtat gtcggggagc tgatctctga tgctgaggct     3300

gatgtgagag aggatgattc ttacctcttc gacttagaca acaaggatgg agaggtgtac     3360

tgcatagatg cccgttacta tggcaacatc agccgcttca tcaaccacct gtgtgacccc     3420

aacatcattc ccgtccgggt cttcatgctg caccaagacc tgcgatttcc acgcatcgcc     3480

ttcttcagtt cccgagacat ccggactggg gaggagctag ggtttgacta tggcgaccgc     3540

ttctgggaca tcaaaagcaa atatttcacc tgccaatgtg gctctgagaa gtgcaagcac     3600

tcagccgaag ccattgccct ggagcagagc cgtctggccc gcctggaccc acaccctgag     3660

ctgctgcccg agctcggctc cctgccccct gtcaacacat ga                        3702


<210>  46
<211>  1233
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Arg Gly Leu Pro Arg Gly Arg Gly Leu Met Arg Ala Arg Gly Arg 
1               5                   10                  15      


Gly Arg Ala Ala Pro Pro Gly Ser Arg Gly Arg Gly Arg Gly Gly Pro 
            20                  25                  30          


His Arg Gly Arg Gly Arg Pro Arg Ser Leu Leu Ser Leu Pro Arg Ala 
        35                  40                  45              


Gln Ala Ser Trp Thr Pro Gln Leu Ser Thr Gly Leu Thr Ser Pro Pro 
    50                  55                  60                  


Val Pro Cys Leu Pro Ser Gln Gly Glu Ala Pro Ala Glu Met Gly Ala 
65                  70                  75                  80  


Leu Leu Leu Glu Lys Glu Thr Arg Gly Ala Thr Glu Arg Val His Gly 
                85                  90                  95      


Ser Leu Gly Asp Thr Pro Arg Ser Glu Glu Thr Leu Pro Lys Ala Thr 
            100                 105                 110         


Pro Asp Ser Leu Glu Pro Ala Gly Pro Ser Ser Pro Ala Ser Val Thr 
        115                 120                 125             


Val Thr Val Gly Asp Glu Gly Ala Asp Thr Pro Val Gly Ala Thr Pro 
    130                 135                 140                 


Leu Ile Gly Asp Glu Ser Glu Asn Leu Glu Gly Asp Gly Asp Leu Arg 
145                 150                 155                 160 


Gly Gly Arg Ile Leu Leu Gly His Ala Thr Lys Ser Phe Pro Ser Ser 
                165                 170                 175     


Pro Ser Lys Gly Gly Ser Cys Pro Ser Arg Ala Lys Met Ser Met Thr 
            180                 185                 190         


Gly Ala Gly Lys Ser Pro Pro Ser Val Gln Ser Leu Ala Met Arg Leu 
        195                 200                 205             


Leu Ser Met Pro Gly Ala Gln Gly Ala Ala Ala Ala Gly Ser Glu Pro 
    210                 215                 220                 


Pro Pro Ala Thr Thr Ser Pro Glu Gly Gln Pro Lys Val His Arg Ala 
225                 230                 235                 240 


Arg Lys Thr Met Ser Lys Pro Gly Asn Gly Gln Pro Pro Val Pro Glu 
                245                 250                 255     


Lys Arg Pro Pro Glu Ile Gln His Phe Arg Met Ser Asp Asp Val His 
            260                 265                 270         


Ser Leu Gly Lys Val Thr Ser Asp Leu Ala Lys Arg Arg Lys Leu Asn 
        275                 280                 285             


Ser Gly Gly Gly Leu Ser Glu Glu Leu Gly Ser Ala Arg Arg Ser Gly 
    290                 295                 300                 


Glu Val Thr Leu Thr Lys Gly Asp Pro Gly Ser Leu Glu Glu Trp Glu 
305                 310                 315                 320 


Thr Val Val Gly Asp Asp Phe Ser Leu Tyr Tyr Asp Ser Tyr Ser Val 
                325                 330                 335     


Asp Glu Arg Val Asp Ser Asp Ser Lys Ser Glu Val Glu Ala Leu Thr 
            340                 345                 350         


Glu Gln Leu Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
        355                 360                 365             


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Glu Ser 
    370                 375                 380                 


Gly Asn Gln Ser Asp Arg Ser Gly Ser Ser Gly Arg Arg Lys Ala Lys 
385                 390                 395                 400 


Lys Lys Trp Arg Lys Asp Ser Pro Trp Val Lys Pro Ser Arg Lys Arg 
                405                 410                 415     


Arg Lys Arg Glu Pro Pro Arg Ala Lys Glu Pro Arg Gly Val Ser Asn 
            420                 425                 430         


Asp Thr Ser Ser Leu Glu Thr Glu Arg Gly Phe Glu Glu Leu Pro Leu 
        435                 440                 445             


Cys Ser Cys Arg Met Glu Ala Pro Lys Ile Asp Arg Ile Ser Glu Arg 
    450                 455                 460                 


Ala Gly His Lys Cys Met Ala Thr Glu Ser Val Asp Gly Glu Leu Ser 
465                 470                 475                 480 


Gly Cys Asn Ala Ala Ile Leu Lys Arg Glu Thr Met Arg Pro Ser Ser 
                485                 490                 495     


Arg Val Ala Leu Met Val Leu Cys Glu Thr His Arg Ala Arg Met Val 
            500                 505                 510         


Lys His His Cys Cys Pro Gly Cys Gly Tyr Phe Cys Thr Ala Gly Thr 
        515                 520                 525             


Phe Leu Glu Cys His Pro Asp Phe Arg Val Ala His Arg Phe His Lys 
    530                 535                 540                 


Ala Cys Val Ser Gln Leu Asn Gly Met Val Phe Cys Pro His Cys Gly 
545                 550                 555                 560 


Glu Asp Ala Ser Glu Ala Gln Glu Val Thr Ile Pro Arg Gly Asp Gly 
                565                 570                 575     


Val Thr Pro Pro Ala Gly Thr Ala Ala Pro Ala Pro Pro Pro Leu Ser 
            580                 585                 590         


Gln Asp Val Pro Gly Arg Ala Asp Thr Ser Gln Pro Ser Ala Arg Met 
        595                 600                 605             


Arg Gly His Gly Glu Pro Arg Arg Pro Pro Cys Asp Pro Leu Ala Asp 
    610                 615                 620                 


Thr Ile Asp Ser Ser Gly Pro Ser Leu Thr Leu Pro Asn Gly Gly Cys 
625                 630                 635                 640 


Leu Ser Ala Val Gly Leu Pro Leu Gly Pro Gly Arg Glu Ala Leu Glu 
                645                 650                 655     


Lys Ala Leu Val Ile Gln Glu Ser Glu Arg Arg Lys Lys Leu Arg Phe 
            660                 665                 670         


His Pro Arg Gln Leu Tyr Leu Ser Val Lys Gln Gly Glu Leu Gln Lys 
        675                 680                 685             


Val Ile Leu Met Leu Leu Asp Asn Leu Asp Pro Asn Phe Gln Ser Asp 
    690                 695                 700                 


Gln Gln Ser Lys Arg Thr Pro Leu His Ala Ala Ala Gln Lys Gly Ser 
705                 710                 715                 720 


Val Glu Ile Cys His Val Leu Leu Gln Ala Gly Ala Asn Ile Asn Ala 
                725                 730                 735     


Val Asp Lys Gln Gln Arg Thr Pro Leu Met Glu Ala Val Val Asn Asn 
            740                 745                 750         


His Leu Glu Val Ala Arg Tyr Met Val Gln Arg Gly Gly Cys Val Tyr 
        755                 760                 765             


Ser Lys Glu Glu Asp Gly Ser Thr Cys Leu His His Ala Ala Lys Ile 
    770                 775                 780                 


Gly Asn Leu Glu Met Val Ser Leu Leu Leu Ser Thr Gly Gln Val Asp 
785                 790                 795                 800 


Val Asn Ala Gln Asp Ser Gly Gly Trp Thr Pro Ile Ile Trp Ala Ala 
                805                 810                 815     


Glu His Lys His Ile Glu Val Ile Arg Met Leu Leu Thr Arg Gly Ala 
            820                 825                 830         


Asp Val Thr Leu Thr Asp Asn Glu Glu Asn Ile Cys Leu His Trp Ala 
        835                 840                 845             


Ser Phe Thr Gly Ser Ala Ala Ile Ala Glu Val Leu Leu Asn Ala Arg 
    850                 855                 860                 


Cys Asp Leu His Ala Val Asn Tyr His Gly Asp Thr Pro Leu His Ile 
865                 870                 875                 880 


Ala Ala Arg Glu Ser Tyr His Asp Cys Val Leu Leu Phe Leu Ser Arg 
                885                 890                 895     


Gly Ala Asn Pro Glu Leu Arg Asn Lys Glu Gly Asp Thr Ala Trp Asp 
            900                 905                 910         


Leu Thr Pro Glu Arg Ser Asp Val Trp Phe Ala Leu Gln Leu Asn Arg 
        915                 920                 925             


Lys Leu Arg Leu Gly Val Gly Asn Arg Ala Ile Arg Thr Glu Lys Ile 
    930                 935                 940                 


Ile Cys Arg Asp Val Ala Arg Gly Tyr Glu Asn Val Pro Ile Pro Cys 
945                 950                 955                 960 


Val Asn Gly Val Asp Gly Glu Pro Cys Pro Glu Asp Tyr Lys Tyr Ile 
                965                 970                 975     


Ser Glu Asn Cys Glu Thr Ser Thr Met Asn Ile Asp Arg Asn Ile Thr 
            980                 985                 990         


His Leu Gln His Cys Thr Cys Val  Asp Asp Cys Ser Ser  Ser Asn Cys 
        995                 1000                 1005             


Leu Cys  Gly Gln Leu Ser Ile  Arg Cys Trp Tyr Asp  Lys Asp Gly 
    1010                 1015                 1020             


Arg Leu  Leu Gln Glu Phe Asn  Lys Ile Glu Pro Pro  Leu Ile Phe 
    1025                 1030                 1035             


Glu Cys  Asn Gln Ala Cys Ser  Cys Trp Arg Asn Cys  Lys Asn Arg 
    1040                 1045                 1050             


Val Val  Gln Ser Gly Ile Lys  Val Arg Leu Gln Leu  Tyr Arg Thr 
    1055                 1060                 1065             


Ala Lys  Met Gly Trp Gly Val  Arg Ala Leu Gln Thr  Ile Pro Gln 
    1070                 1075                 1080             


Gly Thr  Phe Ile Cys Glu Tyr  Val Gly Glu Leu Ile  Ser Asp Ala 
    1085                 1090                 1095             


Glu Ala  Asp Val Arg Glu Asp  Asp Ser Tyr Leu Phe  Asp Leu Asp 
    1100                 1105                 1110             


Asn Lys  Asp Gly Glu Val Tyr  Cys Ile Asp Ala Arg  Tyr Tyr Gly 
    1115                 1120                 1125             


Asn Ile  Ser Arg Phe Ile Asn  His Leu Cys Asp Pro  Asn Ile Ile 
    1130                 1135                 1140             


Pro Val  Arg Val Phe Met Leu  His Gln Asp Leu Arg  Phe Pro Arg 
    1145                 1150                 1155             


Ile Ala  Phe Phe Ser Ser Arg  Asp Ile Arg Thr Gly  Glu Glu Leu 
    1160                 1165                 1170             


Gly Phe  Asp Tyr Gly Asp Arg  Phe Trp Asp Ile Lys  Ser Lys Tyr 
    1175                 1180                 1185             


Phe Thr  Cys Gln Cys Gly Ser  Glu Lys Cys Lys His  Ser Ala Glu 
    1190                 1195                 1200             


Ala Ile  Ala Leu Glu Gln Ser  Arg Leu Ala Arg Leu  Asp Pro His 
    1205                 1210                 1215             


Pro Glu  Leu Leu Pro Glu Leu  Gly Ser Leu Pro Pro  Val Asn Thr 
    1220                 1225                 1230             


<210>  47
<211>  2427
<212>  DNA
<213>  Homo sapiens

<400>  47
atggccgccg ccgatgccga ggcagttccg gcgagggggg agcctcagca ggattgctgt       60

gtgaaaaccg agctgctggg agaagagaca cctatggctg ccgatgaagg ctcagcagag      120

aaacaggcag gagaggccca catggctgcg gacggtgaga ccaatgggtc ttgtgaaaac      180

agcgatgcca gcagtcatgc aaatgctgca aagcacactc aggacagcgc aagggtcaac      240

ccccaggatg gcaccaacac actaactcgg atagcggaaa atggggtttc agaaagagac      300

tcagaagcgg cgaagcaaaa ccacgtcact gccgacgact ttgtgcagac ttctgtcatc      360

ggcagcaacg gatacatctt aaataagccg gccctacagg cacagccctt gaggactacc      420

agcactctgg cctcttcgct gcctggccat gctgcaaaaa cccttcctgg aggggctggc      480

aaaggcagga ctccaagcgc ttttccccag acgccagccg ccccaccagc cacccttggg      540

gaggggagtg ctgacacaga ggacaggaag ctcccggccc ctggcgccga cgtcaaggtc      600

cacagggcac gcaagaccat gccgaagtcc gtcgtgggcc tgcatgcagc cagtaaagat      660

cccagagaag ttcgagaagc tagagatcat aaggaaccaa aagaggagat caacaaaaac      720

atttctgact ttggacgaca gcagctttta ccccccttcc catcccttca tcagtcgcta      780

cctcagaacc agtgctacat ggccaccaca aaatcacaga cagcttgctt gccttttgtt      840

ttagcagctg cagtatctcg gaagaaaaaa cgaagaatgg gaacctatag cctggttcct      900

aagaaaaaga ccaaagtatt aaaacagagg acggtgattg agatgtttaa gagcataact      960

cattccactg tgggttccaa gggggagaag gacctgggcg ccagcagcct gcacgtgaat     1020

ggggagagcc tggagatgga ctcggatgag gacgactcag aggagctcga ggaggacgac     1080

ggccatggtg cagagcaggc ggccgcgttc cccacagagg acagcaggac ttccaaggag     1140

agcatgtcgg aggctgatcg cgcccagaag atggacgggg agtccgagga ggagcaggag     1200

tccgtggaca ccggggagga ggaggaaggc ggtgacgagt ctgacctgag ttcggaatcc     1260

agcattaaga agaaatttct caagaggaaa ggaaagaccg acagtccctg gatcaagcca     1320

gccaggaaaa ggaggcggag aagtagaaag aagcccagcg gtgccctcgg ttctgagtcg     1380

tataagtcat ctgcaggaag cgctgagcag acggcaccag gagacagcac agggtacatg     1440

gaagtttctc tggactccct ggatctccga gtcaaaggaa ttctgtcttc acaagcagaa     1500

gggttggcca acggtccaga tgtgctggag acagacggcc tccaggaagt gcctctctgc     1560

agctgccgga tggaaacacc gaagagtcga gagatcacca cactggccaa caaccagtgc     1620

atggctacag agagcgtgga ccatgaattg ggccggtgca caaacagcgt ggtcaagtat     1680

gagctgatgc gcccctccaa caaggccccg ctcctcgtgc tgtgtgaaga ccaccggggc     1740

cgcatggtga agcaccagtg ctgtcctggc tgtggctact tctgcacagc gggtaatttt     1800

atggagtgtc agcccgagag cagcatctct caccgtttcc acaaagactg tgcctctcga     1860

gtcaataacg ccagctattg tccccactgt ggggaggaga gctccaaggc caaagaggtg     1920

acgatagcta aagcagacac cacctcgacc gtgacaccag tccccgggca ggagaagggc     1980

tcggccctgg agggcagggc cgacaccaca acgggcagtg ctgccgggcc accactctcg     2040

gaggacgaca agctgcaggg tgcagcctcc cacgtgcccg agggctttga tccaacggga     2100

cctgctgggc ttgggaggcc aactcccggc ctttcccagg gaccagggaa ggaaaccttg     2160

gagagcgctc tcatcgccct cgactcggaa aaacccaaga agcttcgctt ccacccaaag     2220

cagctgtact tctccgccag gcaaggggag cttcagaagg tgctcctcat gctggtggac     2280

ggaattgacc ccaacttcaa aatggagcac cagaataagc gctctccact gcacgccgcg     2340

gcagaggctg gacacgtgga catctgccac atgctggttc agttctgcag gctgggaagc     2400

ccaaggtcga ggggctgcct ttggtga                                         2427


<210>  48
<211>  808
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ala Ala Ala Asp Ala Glu Ala Val Pro Ala Arg Gly Glu Pro Gln 
1               5                   10                  15      


Gln Asp Cys Cys Val Lys Thr Glu Leu Leu Gly Glu Glu Thr Pro Met 
            20                  25                  30          


Ala Ala Asp Glu Gly Ser Ala Glu Lys Gln Ala Gly Glu Ala His Met 
        35                  40                  45              


Ala Ala Asp Gly Glu Thr Asn Gly Ser Cys Glu Asn Ser Asp Ala Ser 
    50                  55                  60                  


Ser His Ala Asn Ala Ala Lys His Thr Gln Asp Ser Ala Arg Val Asn 
65                  70                  75                  80  


Pro Gln Asp Gly Thr Asn Thr Leu Thr Arg Ile Ala Glu Asn Gly Val 
                85                  90                  95      


Ser Glu Arg Asp Ser Glu Ala Ala Lys Gln Asn His Val Thr Ala Asp 
            100                 105                 110         


Asp Phe Val Gln Thr Ser Val Ile Gly Ser Asn Gly Tyr Ile Leu Asn 
        115                 120                 125             


Lys Pro Ala Leu Gln Ala Gln Pro Leu Arg Thr Thr Ser Thr Leu Ala 
    130                 135                 140                 


Ser Ser Leu Pro Gly His Ala Ala Lys Thr Leu Pro Gly Gly Ala Gly 
145                 150                 155                 160 


Lys Gly Arg Thr Pro Ser Ala Phe Pro Gln Thr Pro Ala Ala Pro Pro 
                165                 170                 175     


Ala Thr Leu Gly Glu Gly Ser Ala Asp Thr Glu Asp Arg Lys Leu Pro 
            180                 185                 190         


Ala Pro Gly Ala Asp Val Lys Val His Arg Ala Arg Lys Thr Met Pro 
        195                 200                 205             


Lys Ser Val Val Gly Leu His Ala Ala Ser Lys Asp Pro Arg Glu Val 
    210                 215                 220                 


Arg Glu Ala Arg Asp His Lys Glu Pro Lys Glu Glu Ile Asn Lys Asn 
225                 230                 235                 240 


Ile Ser Asp Phe Gly Arg Gln Gln Leu Leu Pro Pro Phe Pro Ser Leu 
                245                 250                 255     


His Gln Ser Leu Pro Gln Asn Gln Cys Tyr Met Ala Thr Thr Lys Ser 
            260                 265                 270         


Gln Thr Ala Cys Leu Pro Phe Val Leu Ala Ala Ala Val Ser Arg Lys 
        275                 280                 285             


Lys Lys Arg Arg Met Gly Thr Tyr Ser Leu Val Pro Lys Lys Lys Thr 
    290                 295                 300                 


Lys Val Leu Lys Gln Arg Thr Val Ile Glu Met Phe Lys Ser Ile Thr 
305                 310                 315                 320 


His Ser Thr Val Gly Ser Lys Gly Glu Lys Asp Leu Gly Ala Ser Ser 
                325                 330                 335     


Leu His Val Asn Gly Glu Ser Leu Glu Met Asp Ser Asp Glu Asp Asp 
            340                 345                 350         


Ser Glu Glu Leu Glu Glu Asp Asp Gly His Gly Ala Glu Gln Ala Ala 
        355                 360                 365             


Ala Phe Pro Thr Glu Asp Ser Arg Thr Ser Lys Glu Ser Met Ser Glu 
    370                 375                 380                 


Ala Asp Arg Ala Gln Lys Met Asp Gly Glu Ser Glu Glu Glu Gln Glu 
385                 390                 395                 400 


Ser Val Asp Thr Gly Glu Glu Glu Glu Gly Gly Asp Glu Ser Asp Leu 
                405                 410                 415     


Ser Ser Glu Ser Ser Ile Lys Lys Lys Phe Leu Lys Arg Lys Gly Lys 
            420                 425                 430         


Thr Asp Ser Pro Trp Ile Lys Pro Ala Arg Lys Arg Arg Arg Arg Ser 
        435                 440                 445             


Arg Lys Lys Pro Ser Gly Ala Leu Gly Ser Glu Ser Tyr Lys Ser Ser 
    450                 455                 460                 


Ala Gly Ser Ala Glu Gln Thr Ala Pro Gly Asp Ser Thr Gly Tyr Met 
465                 470                 475                 480 


Glu Val Ser Leu Asp Ser Leu Asp Leu Arg Val Lys Gly Ile Leu Ser 
                485                 490                 495     


Ser Gln Ala Glu Gly Leu Ala Asn Gly Pro Asp Val Leu Glu Thr Asp 
            500                 505                 510         


Gly Leu Gln Glu Val Pro Leu Cys Ser Cys Arg Met Glu Thr Pro Lys 
        515                 520                 525             


Ser Arg Glu Ile Thr Thr Leu Ala Asn Asn Gln Cys Met Ala Thr Glu 
    530                 535                 540                 


Ser Val Asp His Glu Leu Gly Arg Cys Thr Asn Ser Val Val Lys Tyr 
545                 550                 555                 560 


Glu Leu Met Arg Pro Ser Asn Lys Ala Pro Leu Leu Val Leu Cys Glu 
                565                 570                 575     


Asp His Arg Gly Arg Met Val Lys His Gln Cys Cys Pro Gly Cys Gly 
            580                 585                 590         


Tyr Phe Cys Thr Ala Gly Asn Phe Met Glu Cys Gln Pro Glu Ser Ser 
        595                 600                 605             


Ile Ser His Arg Phe His Lys Asp Cys Ala Ser Arg Val Asn Asn Ala 
    610                 615                 620                 


Ser Tyr Cys Pro His Cys Gly Glu Glu Ser Ser Lys Ala Lys Glu Val 
625                 630                 635                 640 


Thr Ile Ala Lys Ala Asp Thr Thr Ser Thr Val Thr Pro Val Pro Gly 
                645                 650                 655     


Gln Glu Lys Gly Ser Ala Leu Glu Gly Arg Ala Asp Thr Thr Thr Gly 
            660                 665                 670         


Ser Ala Ala Gly Pro Pro Leu Ser Glu Asp Asp Lys Leu Gln Gly Ala 
        675                 680                 685             


Ala Ser His Val Pro Glu Gly Phe Asp Pro Thr Gly Pro Ala Gly Leu 
    690                 695                 700                 


Gly Arg Pro Thr Pro Gly Leu Ser Gln Gly Pro Gly Lys Glu Thr Leu 
705                 710                 715                 720 


Glu Ser Ala Leu Ile Ala Leu Asp Ser Glu Lys Pro Lys Lys Leu Arg 
                725                 730                 735     


Phe His Pro Lys Gln Leu Tyr Phe Ser Ala Arg Gln Gly Glu Leu Gln 
            740                 745                 750         


Lys Val Leu Leu Met Leu Val Asp Gly Ile Asp Pro Asn Phe Lys Met 
        755                 760                 765             


Glu His Gln Asn Lys Arg Ser Pro Leu His Ala Ala Ala Glu Ala Gly 
    770                 775                 780                 


His Val Asp Ile Cys His Met Leu Val Gln Phe Cys Arg Leu Gly Ser 
785                 790                 795                 800 


Pro Arg Ser Arg Gly Cys Leu Trp 
                805             


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic oligopeptide

<400>  49

Ile Glu Gly Arg Met Asp Pro 
1               5           


<210>  50
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  50
aatggccaaa aagcatgtag                                                   20


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  51
ggtgagtgag taaacaagcc                                                   20


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  52
gtaaacaagc ctgggccggg                                                   20


<210>  53
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  53
gtgagtgagt aaacaagcct                                                   20


