                         SEQUENCE LISTING

<110>  ALNYLAM PHARMACEUTICALS, INC.
 
<120>  DOSING OF SIRNA COMPOUNDS TO THE CISTERNA MAGNA

<130>  BN00005.0182

<150>  63/157,474
<151>  2021-03-05

<150>  63/214,716
<151>  2021-06-24

<160>  60    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  1

Gly Arg Gly Asp Ser Pro Lys Cys 
1               5               


<210>  2
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  2

Arg Gly Asp Phe Cys 
1               5   


<210>  3
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  3

Ala Ala Leu Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Glu Ala 
1               5                   10                  15      


Leu Glu Ala Leu Ala Glu Ala Ala Ala Ala Gly Gly Cys 
            20                  25                  


<210>  4
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  4

Ala Ala Leu Ala Glu Ala Leu Ala Glu Ala Leu Ala Glu Ala Leu Ala 
1               5                   10                  15      


Glu Ala Leu Ala Glu Ala Leu Ala Ala Ala Ala Gly Gly Cys 
            20                  25                  30  


<210>  5
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  5

Ala Leu Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Glu Ala 
1               5                   10                  15  


<210>  6
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  6

Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Trp Asp Tyr Gly 
            20          


<210>  7
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  7

Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Trp Tyr Gly 
            20              


<210>  8
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  8

Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Trp Tyr Gly Cys Gly Leu Phe Glu Ala Ile Glu Gly 
            20                  25                  30          


Phe Ile Glu Asn Gly Trp Glu Gly Met Ile Asp Gly Trp Tyr Gly Cys 
        35                  40                  45              


<210>  9
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  9

Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Gly Cys Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile 
            20                  25                  30          


Glu Asn Gly Trp Glu Gly Met Ile Asp Gly Gly Cys 
        35                  40                  


<210>  10
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  10

Gly Leu Phe Gly Ala Leu Ala Glu Ala Leu Ala Glu Ala Leu Ala Glu 
1               5                   10                  15      


His Leu Ala Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Ala Gly 
            20                  25                  30          


Gly Ser Cys 
        35  


<210>  11
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  11

Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Leu Ala Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Ala Gly Gly 
            20                  25                  30          


Ser Cys 
        


<210>  12
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  12

Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Asn Ile Asp Gly Lys Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu 
            20                  25                  30          


Asn Gly Trp Glu Gly Asn Ile Asp Gly 
        35                  40      


<210>  13
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  13

Leu Phe Glu Ala Leu Leu Glu Leu Leu Glu Ser Leu Trp Glu Leu Leu 
1               5                   10                  15      


Leu Glu Ala 
            


<210>  14
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  14

Gly Leu Phe Lys Ala Leu Leu Lys Leu Leu Lys Ser Leu Trp Lys Leu 
1               5                   10                  15      


Leu Leu Lys Ala 
            20  


<210>  15
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  15

Gly Leu Phe Arg Ala Leu Leu Arg Leu Leu Arg Ser Leu Trp Arg Leu 
1               5                   10                  15      


Leu Leu Arg Ala 
            20  


<210>  16
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  16

Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala Leu Ala Lys His 
1               5                   10                  15      


Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Ala Cys Glu Ala 
            20                  25                  30  


<210>  17
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  17

Gly Leu Phe Phe Glu Ala Ile Ala Glu Phe Ile Glu Gly Gly Trp Glu 
1               5                   10                  15      


Gly Leu Ile Glu Gly Cys 
            20          


<210>  18
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  18

Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      


Ile Ser Trp Ile Lys Arg Lys Arg Gln Gln 
            20                  25      


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  19

His His His His His Trp Tyr Gly 
1               5               


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  20

Cys His Lys Lys Lys Lys Lys Lys His Cys 
1               5                   10  


<210>  21
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  21

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  22
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  22

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln Cys 
1               5                   10                  


<210>  23
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  23

Gly Ala Leu Phe Leu Gly Trp Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210>  24
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  24

Leu Leu Ile Ile Leu Arg Arg Arg Ile Arg Lys Gln Ala His Ala His 
1               5                   10                  15      


Ser Lys 
        


<210>  25
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  25

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Lys Ile Asn Leu Lys 
1               5                   10                  15      


Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25      


<210>  26
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  26

Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  27

Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  28

Lys Phe Phe Lys Phe Phe Lys Phe Phe Lys 
1               5                   10  


<210>  29
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  29

Leu Leu Gly Asp Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly Lys Glu 
1               5                   10                  15      


Phe Lys Arg Ile Val Gln Arg Ile Lys Asp Phe Leu Arg Asn Leu Val 
            20                  25                  30          


Pro Arg Thr Glu Ser 
        35          


<210>  30
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  30

Ser Trp Leu Ser Lys Thr Ala Lys Lys Leu Glu Asn Ser Ala Lys Lys 
1               5                   10                  15      


Arg Ile Ser Glu Gly Ile Ala Ile Ala Ile Gln Gly Gly Pro Arg 
            20                  25                  30      


<210>  31
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  31

Ala Cys Tyr Cys Arg Ile Pro Ala Cys Ile Ala Gly Glu Arg Arg Tyr 
1               5                   10                  15      


Gly Thr Cys Ile Tyr Gln Gly Arg Leu Trp Ala Phe Cys Cys 
            20                  25                  30  


<210>  32
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  32

Asp His Tyr Asn Cys Val Ser Ser Gly Gly Gln Cys Leu Tyr Ser Ala 
1               5                   10                  15      


Cys Pro Ile Phe Thr Lys Ile Gln Gly Thr Cys Tyr Arg Gly Lys Ala 
            20                  25                  30          


Lys Cys Cys Lys 
        35      


<210>  33
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  33

Arg Arg Arg Pro Arg Pro Pro Tyr Leu Pro Arg Pro Arg Pro Pro Pro 
1               5                   10                  15      


Phe Phe Pro Pro Arg Leu Pro Pro Arg Ile Pro Pro Gly Phe Pro Pro 
            20                  25                  30          


Arg Phe Pro Pro Arg Phe Pro Gly Lys Arg 
        35                  40          


<210>  34
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  34

Ile Leu Pro Trp Lys Trp Pro Trp Trp Pro Trp Arg Arg 
1               5                   10              


<210>  35
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  35

Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 
1               5                   10                  15      


<210>  36
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  36

Ala Ala Leu Leu Pro Val Leu Leu Ala Ala Pro 
1               5                   10      


<210>  37
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  37

Arg Lys Cys Arg Ile Val Val Ile Arg Val Cys Arg 
1               5                   10          


<210>  38
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  38
aaaauccaac cuacaaguuc a                                                 21


<210>  39
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  39
ugaacutgua gguuggauuu ucg                                               23


<210>  40
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  40
cgaaaaucca accuacaagu ucu                                               23


<210>  41
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  41
ugaacutgua gguuggauuu ucg                                               23


<210>  42
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  42
ugaacutgua gguuggauuu ucg                                               23


<210>  43
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  43
aaaauccaac cuacaaguuc a                                                 21


<210>  44
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  44
ugaacutgua gguuggauuu ucg                                               23


<210>  45
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  45
ggcuacgaaa auccaaccua a                                                 21


<210>  46
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  46
aaagagcaaa acuauucaga a                                                 21


<210>  47
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  47
aaagagcaaa acuauucaga a                                                 21


<210>  48
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  48
uuuaugauuu acucauuauc a                                                 21


<210>  49
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  49
ggcuacgaaa auccaaccua a                                                 21


<210>  50
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  50
aaagagcaaa acuauucaga a                                                 21


<210>  51
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  51
aaagagcaaa acuauucaga a                                                 21


<210>  52
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  52
uuuaugauuu acucauuauc a                                                 21


<210>  53
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  53
uuaggutgga utuucguagc cgu                                               23


<210>  54
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  54
uucugaauag utuugcucuu ucu                                               23


<210>  55
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  55
uucugaauag utuugcucuu ucu                                               23


<210>  56
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  56
ugauaaugag uaaaucauaa aug                                               23


<210>  57
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  57
uuaggutgga utuucguagc cgu                                               23


<210>  58
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  58
uucugaauag utuugcucuu ucu                                               23


<210>  59
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  59
uucugaauag utuugcucuu ucu                                               23


<210>  60
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  60
ugauaaugag uaaaucauaa aug                                               23


