                         SEQUENCE LISTING

<110>  The Regents of the University of California
       WANG, Lei
       LIU, Jun
 
<120>  BIOREACTIVE COMPOUNDS AND METHODS OF USE THEREOF

<130>  048536-709001WO

<150>  63/214,432
<151>  2021-06-24

<150>  63/155,222
<151>  2021-03-01

<160>  101   

<170>  PatentIn version 3.5

<210>  1
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  1

Met Thr Val Lys Tyr Thr Asp Ala Gln Ile Gln Arg Leu Arg Glu Tyr 
1               5                   10                  15      


Gly Asn Gly Thr Tyr Glu Gln Lys Val Phe Glu Asp Leu Ala Ser Arg 
            20                  25                  30          


Asp Ala Ala Phe Ser Lys Glu Met Ser Val Ala Ser Thr Asp Asn Glu 
        35                  40                  45              


Lys Lys Ile Lys Gly Met Ile Ala Asn Pro Ser Arg His Gly Leu Thr 
    50                  55                  60                  


Gln Leu Met Asn Asp Ile Ala Asp Ala Leu Val Ala Glu Gly Phe Ile 
65                  70                  75                  80  


Glu Val Arg Thr Pro Ile Phe Ile Ser Lys Asp Ala Leu Ala Arg Met 
                85                  90                  95      


Thr Ile Thr Glu Asp Lys Pro Leu Phe Lys Gln Val Phe Trp Ile Asp 
            100                 105                 110         


Glu Lys Arg Ala Leu Arg Pro Met Leu Ala Pro Asn Leu Tyr Ser Val 
        115                 120                 125             


Met Arg Asp Leu Arg Asp His Thr Asp Gly Pro Val Lys Ile Phe Glu 
    130                 135                 140                 


Met Gly Ser Cys Phe Arg Lys Glu Ser His Ser Gly Met His Leu Glu 
145                 150                 155                 160 


Glu Phe Thr Met Leu Asn Leu Val Asp Met Gly Pro Arg Gly Asp Ala 
                165                 170                 175     


Thr Glu Val Leu Lys Asn Tyr Ile Ser Val Val Met Lys Ala Ala Gly 
            180                 185                 190         


Leu Pro Asp Tyr Asp Leu Val Gln Glu Glu Ser Asp Val Tyr Lys Glu 
        195                 200                 205             


Thr Ile Asp Val Glu Ile Asn Gly Gln Glu Val Cys Ser Ala Ala Val 
    210                 215                 220                 


Gly Pro His Tyr Leu Asp Ala Ala His Asp Val His Glu Pro Trp Ser 
225                 230                 235                 240 


Gly Ala Gly Phe Gly Leu Glu Arg Leu Leu Thr Ile Arg Glu Lys Tyr 
                245                 250                 255     


Ser Thr Val Lys Lys Gly Gly Ala Ser Ile Ser Tyr Leu Asn Gly Ala 
            260                 265                 270         


Lys Ile Asn 
        275 


<210>  2
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  2

Met Thr Val Lys Tyr Thr Asp Ala Gln Ile Gln Arg Leu Arg Glu Tyr 
1               5                   10                  15      


Gly Asn Gly Thr Tyr Glu Gln Lys Val Phe Glu Asp Leu Ala Ser Arg 
            20                  25                  30          


Asp Ala Ala Phe Ser Lys Glu Met Ser Val Ala Ser Thr Asp Asn Glu 
        35                  40                  45              


Lys Lys Ile Lys Gly Met Ile Ala Asn Pro Ser Arg His Gly Leu Thr 
    50                  55                  60                  


Gln Leu Met Asn Asp Ile Ala Asp Ala Leu Val Ala Glu Gly Phe Ile 
65                  70                  75                  80  


Glu Val Arg Thr Pro Ile Phe Ile Ser Lys Asp Ala Leu Ala Arg Met 
                85                  90                  95      


Thr Ile Thr Glu Asp Lys Pro Leu Phe Lys Gln Val Phe Trp Ile Asp 
            100                 105                 110         


Glu Lys Arg Ala Leu Arg Pro Met Leu Ala Pro Asn Leu Gly Ser Val 
        115                 120                 125             


Ala Arg Asp Leu Arg Asp His Thr Asp Gly Pro Val Lys Ile Phe Glu 
    130                 135                 140                 


Met Gly Ser Cys Phe Arg Lys Glu Ser His Ser Gly Met His Leu Glu 
145                 150                 155                 160 


Glu Phe Thr Met Leu Asn Leu Phe Asp Met Gly Pro Arg Gly Asp Ala 
                165                 170                 175     


Thr Glu Val Leu Lys Asn Tyr Ile Ser Val Val Met Lys Ala Ala Gly 
            180                 185                 190         


Leu Pro Asp Tyr Asp Leu Val Gln Glu Glu Ser Asp Val Tyr Lys Glu 
        195                 200                 205             


Thr Ile Asp Val Glu Ile Asn Gly Gln Glu Val Cys Ser Ala Ala Val 
    210                 215                 220                 


Gly Pro Thr Pro Ile Asp Ala Ala His Asp Val His Glu Pro Trp Ser 
225                 230                 235                 240 


Gly Ala Gly Phe Gly Leu Glu Arg Leu Leu Thr Ile Arg Glu Lys Tyr 
                245                 250                 255     


Ser Thr Val Lys Lys Gly Gly Ala Ser Ile Ser Tyr Leu Asn Gly Ala 
            260                 265                 270         


Lys Ile Asn 
        275 


<210>  3
<211>  71
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  3
gggggacggt ccggcgacca gcgggtctct aaaacctagc cagcggggtt cgacgccccg       60

gtctctcgcc a                                                            71


<210>  4
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  4

Ala Ala Gly Leu His Leu Gln Glu Ser Ile Ala Glu Gln Gly Ala Leu 
1               5                   10                  15      


Arg 
    


<210>  5
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  5

Ile Glu Leu Ser Ser Ala Gln Gln Thr Asp Val Asn Leu Pro Tyr Ile 
1               5                   10                  15      


Thr Ala Asp Ala Thr Gly Pro Lys 
            20                  


<210>  6
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  6

Trp Lys Glu Gly Glu Ala Thr Leu Ala Pro Ser Leu Asp Leu Val Gly 
1               5                   10                  15      


Lys 
    


<210>  7
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  7

Asp Val Thr Ser Leu Leu Glu Asp Pro Lys Ala Tyr Ala Leu Ser Ile 
1               5                   10                  15      


Asp Leu Leu Val Glu Arg 
            20          


<210>  8
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  8

Ser Gln Thr Val His Phe Cys Ile Gly Asn Pro Val Thr Val Ala Asn 
1               5                   10                  15      


Ser Ile Pro Gln Ala Gly Ser Lys 
            20                  


<210>  9
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  9

Thr Ile Ala Thr Glu Asn Ala Pro Ala Ala Ile Gly Pro Tyr Val Gln 
1               5                   10                  15      


Gly Val Asp Leu Gly Asn Met Ile Ile Thr Ser Gly Gln Ile Pro Val 
            20                  25                  30          


Asn Pro Lys 
        35  


<210>  10
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  10

His Ile Ala His Asp Phe Asn Asp Pro Leu Thr Trp Ser His Asn Arg 
1               5                   10                  15      


<210>  11
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  11

Ala Ser Glu Ile Ser Ile Lys Ala Gly Ala Asp Phe Ile Lys Thr Ser 
1               5                   10                  15      


Thr Gly Lys 
            


<210>  12
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  12

Leu Leu Gln Ala Val Leu Ala Lys Gln Glu Ala Trp Glu Tyr Val Thr 
1               5                   10                  15      


Phe Gln Asp Asp Ala Glu Leu Pro Leu Ala Phe Lys 
            20                  25              


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  13

Val Ala Ala Asp Tyr Leu Lys Gln Lys 
1               5                   


<210>  14
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  14

Leu Thr Ile Pro Glu Glu Lys Leu Ala Val Leu Lys 
1               5                   10          


<210>  15
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  15

Gly Ala Ala Ile Val Gly Ile Phe His Asp Glu Ala Val Arg Asn Asp 
1               5                   10                  15      


Val Ala Asp Arg 
            20  


<210>  16
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  16

Ile Glu Leu Ser Ser Ala Gln Gln Thr Asp Val Asn Leu Pro Tyr Ile 
1               5                   10                  15      


Thr Ala Asp Ala Thr Gly Pro Lys 
            20                  


<210>  17
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  17

Ala Lys Leu Glu Ser Leu Val Glu Asp Leu Val Asn Arg 
1               5                   10              


<210>  18
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  18

Ala Ala Gln Tyr Val Ala Ser His Pro Gly Glu Val Cys Pro Ala Lys 
1               5                   10                  15      


<210>  19
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  19

Glu Gly Glu Ala Thr Leu Ala Pro Ser Leu Asp Leu Val Gly Lys Ile 
1               5                   10                  15      


<210>  20
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  20

Ser Gln Thr Val His Phe Gln Gly Asn Pro Val Thr Val Ala Asn Ser 
1               5                   10                  15      


Ile Pro Gln Ala Gly Ser Lys 
            20              


<210>  21
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  21

Ser Val Asn Asp Val Lys Ala Asp Glu Gln Ile Leu Asp Ile Gly Asp 
1               5                   10                  15      


Ala Ser Ala Gln Glu Leu Ala Glu Ile Leu Lys 
            20                  25          


<210>  22
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  22

Thr Met Lys Ala Gln Gln Pro Pro Ile Arg 
1               5                   10  


<210>  23
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  23

His Glu Pro Glu Leu Gly Leu Ala Ser Gly Thr Asp Gly Leu Lys Leu 
1               5                   10                  15      


Thr Arg 
        


<210>  24
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  24

Thr Ala His Ile Ala Leu Met Asp Ile Asp Pro Thr Arg Leu Glu Glu 
1               5                   10                  15      


Ser His Ile Val Val Arg 
            20          


<210>  25
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  25

Val Gly Asp Ile Val Ile Phe Asn Asp Gly Tyr Gly Val Lys 
1               5                   10                  


<210>  26
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  26

Glu Ala Asp Ile Ile Ile Ser Ser Thr Ala Ser Pro Leu Pro Ile Ile 
1               5                   10                  15      


Gly Lys Gly Met Val Glu Arg 
            20              


<210>  27
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  27

His Asn Asp Ala His Leu Thr Leu Ile His Ile Asp Asp Gly Leu Ser 
1               5                   10                  15      


Glu Leu Tyr Pro Gly Ile Tyr Phe Pro Ala Thr Glu Asp Ile Leu Gln 
            20                  25                  30          


Leu Leu Lys 
        35  


<210>  28
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  28

Met Xaa Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
    50                  55                  60                  


Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Arg 
65                  70                  75                  80  


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                85                  90                  95      


Thr Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
    130                 135                 140                 


Phe Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly 
145                 150                 155                 160 


Ile Lys Ala Asn Phe Lys Ile Arg His Asn Val Glu Asp Gly Ser Val 
                165                 170                 175     


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            180                 185                 190         


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser 
        195                 200                 205             


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
    210                 215                 220                 


Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys Gly Ser 
225                 230                 235                 240 


His His His His His His 
                245     


<210>  29
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (86)..(86)
<223>  Xaa can be any naturally occurring amino acid

<400>  29

Met Lys Leu Phe Tyr Lys Pro Gly Ala Cys Ser Leu Ala Ser His Ile 
1               5                   10                  15      


Thr Leu Arg Glu Ser Gly Lys Asp Phe Thr Leu Val Ser Val Asp Leu 
            20                  25                  30          


Met Lys Lys Arg Leu Glu Asn Gly Asp Asp Tyr Phe Ala Val Asn Pro 
        35                  40                  45              


Lys Gly Gln Val Pro Ala Leu Leu Leu Asp Asp Gly Thr Leu Leu Thr 
    50                  55                  60                  


Glu Gly Val Ala Ile Met Gln Tyr Leu Ala Asp Ser Val Pro Asp Arg 
65                  70                  75                  80  


Gln Leu Leu Ala Pro Xaa Asn Ser Ile Ser Arg Tyr Lys Thr Ile Glu 
                85                  90                  95      


Trp Leu Asn Tyr Ile Ala Thr Glu Leu His Lys Gly Phe Thr Pro Leu 
            100                 105                 110         


Phe Arg Pro Asp Thr Pro Glu Glu Tyr Lys Pro Thr Val Arg Ala Gln 
        115                 120                 125             


Leu Glu Lys Lys Leu Gln Tyr Val Asn Glu Ala Leu Lys Asp Glu His 
    130                 135                 140                 


Trp Ile Cys Gly Gln Arg Phe Thr Ile Ala Asp Ala Tyr Leu Phe Thr 
145                 150                 155                 160 


Val Leu Arg Trp Ala Tyr Ala Val Lys Leu Asn Leu Glu Gly Leu Glu 
                165                 170                 175     


His Ile Ala Ala Phe Met Gln Arg Met Ala Glu Arg Pro Glu Val Gln 
            180                 185                 190         


Asp Ala Leu Ser Ala Glu Gly Leu Lys His His His His His His 
        195                 200                 205         


<210>  30
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (65)..(65)
<223>  Xaa can be any naturally occurring amino acid

<400>  30

Met Lys Leu Phe Tyr Lys Pro Gly Ala Cys Ser Leu Ala Ser His Ile 
1               5                   10                  15      


Thr Leu Arg Glu Ser Gly Lys Asp Phe Thr Leu Val Ser Val Asp Leu 
            20                  25                  30          


Met Lys Lys Arg Leu Glu Asn Gly Asp Asp Tyr Phe Ala Val Asn Pro 
        35                  40                  45              


Lys Gly Gln Val Pro Ala Leu Leu Leu Asp Asp Gly Thr Leu Leu Thr 
    50                  55                  60                  


Xaa Gly Val Ala Ile Met Gln Tyr Leu Ala Asp Ser Val Pro Asp Arg 
65                  70                  75                  80  


Gln Leu Leu Ala Pro Val Asn Ser Ile Ser Arg Tyr Lys Thr Ile Glu 
                85                  90                  95      


Trp Leu Asn Tyr Ile Ala Thr Glu Leu His Lys Gly Phe Thr Pro Leu 
            100                 105                 110         


Phe Arg Pro Asp Thr Pro Glu Glu Tyr Lys Pro Thr Val Arg Ala Gln 
        115                 120                 125             


Leu Glu Lys Lys Leu Gln Tyr Val Asn Glu Ala Leu Lys Asp Glu His 
    130                 135                 140                 


Trp Ile Cys Gly Gln Arg Phe Thr Ile Ala Asp Ala Tyr Leu Phe Thr 
145                 150                 155                 160 


Val Leu Arg Trp Ala Tyr Ala Val Lys Leu Asn Leu Glu Gly Leu Glu 
                165                 170                 175     


His Ile Ala Ala Phe Met Gln Arg Met Ala Glu Arg Pro Glu Val Gln 
            180                 185                 190         


Asp Ala Leu Ser Ala Glu Gly Leu Lys His His His His His His 
        195                 200                 205         


<210>  31
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (86)..(86)
<223>  Xaa can be any naturally occurring amino acid

<400>  31

Met Lys Leu Phe Tyr Lys Pro Gly Ala Cys Ser Leu Ala Ser His Ile 
1               5                   10                  15      


Thr Leu Arg Glu Ser Gly Lys Asp Phe Thr Leu Val Ser Val Asp Leu 
            20                  25                  30          


Met Lys Lys Arg Leu Glu Asn Gly Asp Asp Tyr Phe Ala Val Asn Pro 
        35                  40                  45              


Lys Gly Gln Val Pro Ala Leu Leu Leu Asp Asp Gly Thr Leu Leu Thr 
    50                  55                  60                  


Glu Gly Val Ala Ile Met Gln Tyr Leu Ala Asp Ser Val Pro Asp Arg 
65                  70                  75                  80  


Gln Leu Leu Ala Pro Xaa Asn Ser Ile Ser Arg Ala Lys Thr Ile Glu 
                85                  90                  95      


Trp Leu Asn Tyr Ile Ala Thr Glu Leu His Lys Gly Phe Thr Pro Leu 
            100                 105                 110         


Phe Arg Pro Asp Thr Pro Glu Glu Tyr Lys Pro Thr Val Arg Ala Gln 
        115                 120                 125             


Leu Glu Lys Lys Leu Gln Tyr Val Asn Glu Ala Leu Lys Asp Glu His 
    130                 135                 140                 


Trp Ile Cys Gly Gln Arg Phe Thr Ile Ala Asp Ala Tyr Leu Phe Thr 
145                 150                 155                 160 


Val Leu Arg Trp Ala Tyr Ala Val Lys Leu Asn Leu Glu Gly Leu Glu 
                165                 170                 175     


His Ile Ala Ala Phe Met Gln Arg Met Ala Glu Arg Pro Glu Val Gln 
            180                 185                 190         


Asp Ala Leu Ser Ala Glu Gly Leu Lys His His His His His His 
        195                 200                 205         


<210>  32
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (86)..(86)
<223>  Xaa can be any naturally occurring amino acid

<400>  32

Met Lys Leu Phe Tyr Lys Pro Gly Ala Cys Ser Leu Ala Ser His Ile 
1               5                   10                  15      


Thr Leu Arg Glu Ser Gly Lys Asp Phe Thr Leu Val Ser Val Asp Leu 
            20                  25                  30          


Met Lys Lys Arg Leu Glu Asn Gly Asp Asp Tyr Phe Ala Val Asn Pro 
        35                  40                  45              


Lys Gly Gln Val Pro Ala Leu Leu Leu Asp Asp Gly Thr Leu Leu Thr 
    50                  55                  60                  


Glu Gly Val Ala Ile Met Gln Ala Leu Ala Asp Ser Val Pro Asp Arg 
65                  70                  75                  80  


Gln Leu Leu Ala Pro Xaa Asn Ser Ile Ser Arg Ala Lys Thr Ile Glu 
                85                  90                  95      


Trp Leu Asn Tyr Ile Ala Thr Glu Leu His Lys Gly Phe Thr Pro Leu 
            100                 105                 110         


Phe Arg Pro Asp Thr Pro Glu Glu Tyr Lys Pro Thr Val Arg Ala Gln 
        115                 120                 125             


Leu Glu Lys Lys Leu Gln Tyr Val Asn Glu Ala Leu Lys Asp Glu His 
    130                 135                 140                 


Trp Ile Cys Gly Gln Arg Phe Thr Ile Ala Asp Ala Tyr Leu Phe Thr 
145                 150                 155                 160 


Val Leu Arg Trp Ala Tyr Ala Val Lys Leu Asn Leu Glu Gly Leu Glu 
                165                 170                 175     


His Ile Ala Ala Phe Met Gln Arg Met Ala Glu Arg Pro Glu Val Gln 
            180                 185                 190         


Asp Ala Leu Ser Ala Glu Gly Leu Lys His His His His His His 
        195                 200                 205         


<210>  33
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  33

Met Thr Ser Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu 
1               5                   10                  15      


Val Gln Pro Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu 
            20                  25                  30          


Glu His Leu Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys 
        35                  40                  45              


Phe Glu Leu Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly 
    50                  55                  60                  


Asp Val Lys Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp 
65                  70                  75                  80  


Lys His Asn Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser 
                85                  90                  95      


Met Leu Glu Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile 
            100                 105                 110         


Ala Tyr Ser Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys 
        115                 120                 125             


Leu Pro Glu Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr 
    130                 135                 140                 


Tyr Leu Asn Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp 
145                 150                 155                 160 


Ala Leu Asp Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe 
                165                 170                 175     


Pro Lys Leu Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile 
            180                 185                 190         


Asp Lys Tyr Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly 
        195                 200                 205             


Trp Gln Ala Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu 
    210                 215                 220                 


Val Pro Arg Gly Ser His His His His His His 
225                 230                 235 


<210>  34
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  Xaa can be any naturally occurring amino acid

<400>  34

Met Thr Ser Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu 
1               5                   10                  15      


Val Gln Pro Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu 
            20                  25                  30          


Glu His Leu Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys 
        35                  40                  45              


Phe Glu Leu Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly 
    50                  55                  60                  


Asp Val Lys Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp 
65                  70                  75                  80  


Lys His Asn Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser 
                85                  90                  95      


Met Leu Glu Gly Xaa Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile 
            100                 105                 110         


Ala Tyr Ser Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys 
        115                 120                 125             


Leu Pro Glu Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr 
    130                 135                 140                 


Tyr Leu Asn Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp 
145                 150                 155                 160 


Ala Leu Asp Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe 
                165                 170                 175     


Pro Lys Leu Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile 
            180                 185                 190         


Asp Lys Tyr Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly 
        195                 200                 205             


Trp Gln Ala Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Leu 
    210                 215                 220                 


Val Pro Arg Gly Ser His His His His His His 
225                 230                 235 


<210>  35
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  35

Met Gly Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg 
            20                  25                  30          


Ser Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Asp Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser His His 
        115                 120                 125             


His His His His 
    130         


<210>  36
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa can be any naturally occurring amino acid

<400>  36

Met Gly Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Xaa Ser Arg 
            20                  25                  30          


Ser Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Asp Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser His His 
        115                 120                 125             


His His His His 
    130         


<210>  37
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa can be any naturally occurring amino acid

<400>  37

Met Gly Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Xaa Arg 
            20                  25                  30          


Ser Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Asp Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser His His 
        115                 120                 125             


His His His His 
    130         


<210>  38
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  38
gttgttcata tgaccgtgaa gtacaccgac gcccag                                 36


<210>  39
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  39
caggtttggc gccagcatcg ggcg                                              24


<210>  40
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  n is a, c, g, or t

<400>  40
cgcccgatgc tggcgccaaa cctgnnkagc gtgnnkcgtg acctgcgcga tcacaccgac       60


<210>  41
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  41
cagcatggtg aactcctcca g                                                 21


<210>  42
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  n is a, c, g, or t

<400>  42
ctggaggagt tcaccatgct gnnkctgnnk gatatgggtc cgcgcggcga c                51


<210>  43
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  43
gacccacagc cgcgctgcac acttcctgac cgttaatttc cacgtcgatg                  50


<210>  44
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (31)..(32)
<223>  n is a, c, g, or t

<400>  44
gtgtgcagcg cggctgtggg tccannknnk nnkgatgcgg cccatgacgt gcatgagccg       60


<210>  45
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  45
ggtggtctgc agttaattga ttttggcacc attcaggtag                             40


<210>  46
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  46
ggtggtcata tgtagaaggg cgaggagctg ttcac                                  35


<210>  47
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  47
gttgttaagc ttttagtgat ggtgatggtg atggctgccc ttgtacagct cgtccatg         58


<210>  48
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  48
gagacccaag ctggctagcg ccaccatgac cgtgaagtac accgacgc                    48


<210>  49
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  49
ggctgatcag cgggtttaaa gcggccgctt aattgatttt ggcaccattc                  50


<210>  50
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  50
gttgttaagc ttttaatggt gatggtgatg gtgctttaag ccttccgctg acag             54


<210>  51
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  51
gaccgccagt tgctggcacc gtagaacagt atttcccgct ataaaac                     47


<210>  52
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  52
gttttatagc gggaaatact gttctacggt gccagcaact ggcggtc                     47


<210>  53
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  53
gcaccgtaga acagtatttc ccgcgctaaa accatcgaat ggct                        44


<210>  54
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  54
gcgcgggaaa tactgttcta cggtgccagc aactggcggt cggg                        44


<210>  55
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  55
tgacggaagg cgtagcgatt atgcaggctc ttgccgacag cgtccccga                   49


<210>  56
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  56
gcctgcataa tcgctacgcc ttccgtcagc aaagtaccgt catcca                      46


<210>  57
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  57
ctgctggatg acggtacttt gctgacgtag ggcgtagcga ttatgcagta t                51


<210>  58
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  58
ctacgtcagc aaagtaccgt catccagcag caatgcaggc acctgcccct t                51


<210>  59
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  59
ctttaagaag gagatataca tatgactagt atgtccccta tactag                      46


<210>  60
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  60
ccgccaaaac agccaagctt ttagtgatgg tgatggtgat gggatccacg cggaaccaga       60

tccg                                                                    64


<210>  61
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  61
gatttcaatg cttgaaggat aggttttgga tattagatac ggtg                        44


<210>  62
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  62
caccgtatct aatatccaaa acctatcctt caagcattga aatc                        44


<210>  63
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  63
gtgataaatg gcgaaacaaa gcgtttgaat tgggtttgga gtttc                       45


<210>  64
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  64
gaaactccaa acccaattca aacgctttgt ttcgccattt atcac                       45


<210>  65
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  65
gttgttaagc ttgccaccat gaaattgttc tacaaaccgg gtg                         43


<210>  66
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  66
ggtggtctcg agttaatggt gatggtgatg gtgctttaag                             40


<210>  67
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  67
tgaaggtgat aaatggcgaa acaaatcgtt tgaattgggt ttggag                      46


<210>  68
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  68
gatttgtttc gccatttatc accttcatcg cgctcataca aatgc                       45


<210>  69
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  69
tgaaggtgat aaatggcgaa acaaaacgtt tgaattgggt ttggag                      46


<210>  70
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  70
gttttgtttc gccatttatc accttcatcg cgctcataca aatgc                       45


<210>  71
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  71
gatgaaggtg ataaatggcg aaacaaatat tttgaattgg gtttggagtt                  50


<210>  72
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  72
atatttgttt cgccatttat caccttcatc gcgctcatac aaatgctc                    48


<210>  73
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  73
gatgaaggtg ataaatggcg aaacaaacac tttgaattgg gtttggagtt                  50


<210>  74
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  74
gtgtttgttt cgccatttat caccttcatc gcgctcatac aaatgctc                    48


<210>  75
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  75
ctaacaggag gaattactag tatgaccgtg aagtacaccg ac                          42


<210>  76
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  76
caatgatgat gatgatgatg gtcgacttaa ttgattttgg caccattc                    48


<210>  77
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  77
taagaaggag atatacatat gaaatacctg ctgccgaccg                             40


<210>  78
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  78
tccgccaaaa cagccaagct tttagtggtg gtggtgatga tgggacgaga                  50


<210>  79
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  79
tgacctgtgc tgcgagcggc cgtaccagct agagctacgg catgggttgg ttt              53


<210>  80
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  80
ctagctggta cggccgctcg cagcacaggt caaacggaga ctgccaccgg tt               52


<210>  81
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  81
cctgtgctgc gagcggccgt accagccgct agtacggcat gggttggttt cgt              53


<210>  82
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  82
ctagcggctg gtacggccgc tcgcagcaca ggtcaaacgg agactgccac cg               52


<210>  83
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  83
ttctgcctgg tatggcactc tgtaggaata cgactactgg gg                          42


<210>  84
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  84
ctacagagtg ccataccagg cagaacccgc cgccgcggcg ca                          42


<210>  85
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  85
gttgttcata tgaaattgtt ctacaaaccg ggtgcctgc                              39


<210>  86
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  86

Met His His His His His His Thr Val Lys Tyr Thr Asp Ala Gln Ile 
1               5                   10                  15      


Gln Arg Leu Arg Glu Tyr Gly Asn Gly Thr Tyr Glu Gln Lys Val Phe 
            20                  25                  30          


Glu Asp Leu Ala Ser Arg Asp Ala Ala Phe Ser Lys Glu Met Ser Val 
        35                  40                  45              


Ala Ser Thr Asp Asn Glu Lys Lys Ile Lys Gly Met Ile Ala Asn Pro 
    50                  55                  60                  


Ser Arg His Gly Leu Thr Gln Leu Met Asn Asp Ile Ala Asp Ala Leu 
65                  70                  75                  80  


Val Ala Glu Gly Phe Ile Glu Val Arg Thr Pro Ile Phe Ile Ser Lys 
                85                  90                  95      


Asp Ala Leu Ala Arg Met Thr Ile Thr Glu Asp Lys Pro Leu Phe Lys 
            100                 105                 110         


Gln Val Phe Trp Ile Asp Glu Lys Arg Ala Leu Arg Pro Met Leu Ala 
        115                 120                 125             


Pro Asn Leu Gly Ser Val Ala Arg Asp Leu Arg Asp His Thr Asp Gly 
    130                 135                 140                 


Pro Val Lys Ile Phe Glu Met Gly Ser Cys Phe Arg Lys Glu Ser His 
145                 150                 155                 160 


Ser Gly Met His Leu Glu Glu Phe Thr Met Leu Asn Leu Phe Asp Met 
                165                 170                 175     


Gly Pro Arg Gly Asp Ala Thr Glu Val Leu Lys Asn Tyr Ile Ser Val 
            180                 185                 190         


Val Met Lys Ala Ala Gly Leu Pro Asp Tyr Asp Leu Val Gln Glu Glu 
        195                 200                 205             


Ser Asp Val Tyr Lys Glu Thr Ile Asp Val Glu Ile Asn Gly Gln Glu 
    210                 215                 220                 


Val Cys Ser Ala Ala Val Gly Pro Thr Pro Ile Asp Ala Ala His Asp 
225                 230                 235                 240 


Val His Glu Pro Trp Ser Gly Ala Gly Phe Gly Leu Glu Arg Leu Leu 
                245                 250                 255     


Thr Ile Arg Glu Lys Tyr Ser Thr Val Lys Lys Gly Gly Ala Ser Ile 
            260                 265                 270         


Ser Tyr Leu Asn Gly Ala Lys Ile Asn 
        275                 280     


<210>  87
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  87

Met Thr Val Lys Tyr Thr Asp Ala Gln Ile Gln Arg Leu Arg Glu Tyr 
1               5                   10                  15      


Gly Asn Gly Thr Tyr Glu Gln Lys Val Phe Glu Asp Leu Ala Ser Arg 
            20                  25                  30          


Asp Ala Ala Phe Ser Lys Glu Met Ser Val Ala Ser Thr Asp Asn Glu 
        35                  40                  45              


Lys Lys Ile Lys Gly Met Ile Ala Asn Pro Ser Arg His Gly Leu Thr 
    50                  55                  60                  


Gln Leu Met Asn Asp Ile Ala Asp Ala Leu Val Ala Glu Gly Phe Ile 
65                  70                  75                  80  


Glu Val Arg Thr Pro Ile Phe Ile Ser Lys Asp Ala Leu Ala Arg Met 
                85                  90                  95      


Thr Ile Thr Glu Asp Lys Pro Leu Phe Lys Gln Val Phe Trp Ile Asp 
            100                 105                 110         


Glu Lys Arg Ala Leu Arg Pro Met Leu Ala Pro Asn Leu Gly Ser Val 
        115                 120                 125             


Ala Arg Asp Leu Arg Asp His Thr Asp Gly Pro Val Lys Ile Phe Glu 
    130                 135                 140                 


Met Gly Ser Cys Phe Arg Lys Glu Ser His Ser Gly Met His Leu Glu 
145                 150                 155                 160 


Glu Phe Thr Met Leu Asn Leu Phe Asp Met Gly Pro Arg Gly Asp Ala 
                165                 170                 175     


Thr Glu Val Leu Lys Asn Tyr Ile Ser Val Val Met Lys Ala Ala Gly 
            180                 185                 190         


Leu Pro Asp Tyr Asp Leu Val Gln Glu Glu Ser Asp Val Tyr Lys Glu 
        195                 200                 205             


Thr Ile Asp Val Glu Ile Asn Gly Gln Glu Val Cys Ser Ala Ala Val 
    210                 215                 220                 


Gly Pro Thr Pro Ile Asp Ala Ala His Asp Val His Glu Pro Trp Ser 
225                 230                 235                 240 


Gly Ala Gly Phe Gly Leu Glu Arg Leu Leu Thr Ile Arg Glu Lys Tyr 
                245                 250                 255     


Ser Thr Val Lys Lys Gly Gly Ala Ser Ile Ser Tyr Leu Asn Gly Ala 
            260                 265                 270         


Lys Ile Asn His His His His His His 
        275                 280     


<210>  88
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  88

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  89
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa is FSK

<400>  89

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Xaa Ser Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  90
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa is FSK

<400>  90

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Xaa Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  91
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is FSY

<400>  91

Xaa Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  92
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  Xaa is FSY

<400>  92

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Xaa Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  93
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (113)..(113)
<223>  Xaa is FSY

<400>  93

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
            100                 105                 110         


Xaa Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  94
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (116)..(116)
<223>  Xaa is FSY

<400>  94

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Xaa Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  95
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  95

Arg Thr Ser Arg Ser Tyr Gly Met Gly 
1               5                   


<210>  96
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  96

Gly Ile Ser Trp Arg Gly Asp Ser 
1               5               


<210>  97
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  97

Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr 
1               5                   10                  15  


<210>  98
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is FSK

<400>  98

Arg Thr Ser Xaa Ser Tyr Gly Met Gly 
1               5                   


<210>  99
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is FSK

<400>  99

Arg Thr Ser Arg Xaa Tyr Gly Met Gly 
1               5                   


<210>  100
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa is FSY

<400>  100

Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Xaa Phe Ser Tyr Glu Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  101
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa is FSY

<400>  101

Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Xaa 
1               5                   10                  15  


