                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
       Riley, James L
       Ellis, Gavin
 
<120>  	Targeting T Regulatory Cells to Islet Cells To Stall or Reverse 
       Type 1 Diabetes

<130>  046483-7319WO1(02482)

<150>  US Provisional Patent Application No. 63/200,343
<151>  2021-03-02

<160>  64    

<170>  PatentIn version 3.5

<210>  1
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4hD29 nanobody aa

<400>  1

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asn 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Pro Asp Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Leu Tyr Lys Cys 
                85                  90                  95      


Ala Thr Gly Ala Ala Pro Arg Ile Pro Thr Thr Leu Arg Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  2
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4hD29 nanobody

<400>  2
caagtgcaac ttcaagagtc cggcggtgga cttgtccagc caggagggag cctgcgactt       60

tcctgcgccg ccagtgggtt cacattttcc agtaattata tgacttgggt acgacaggca      120

cctggcaaag gccctgagtg ggtctcagga attaacccgg atggttccag cacatactac      180

gcggattctg ttaagggccg ctttaccatc tcaagggata acgctaagaa taccctttat      240

ctccagatga acagtctcaa aagcgaggac accgcattgt ataaatgtgc aacaggggct      300

gctcctagga ttccaaccac attgagaggt caaggcactc aggtgactgt ctcctca         357


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4hD29 CDR1

<400>  3

Gly Phe Thr Phe Ser Ser Asn Tyr 
1               5               


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4hD29 CDR2

<400>  4

Ile Asn Pro Asp Gly Ser Ser Thr 
1               5               


<210>  5
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 signal peptide aa

<400>  5

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  6
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 signal peptide

<400>  6
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccg                                                                     63


<210>  7
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 hinge aa

<400>  7

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  8
<211>  687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG4 hinge

<400>  8
gagagcaagt acggcccccc ttgccccagc tgtccggcac cagagttcga agggggaccc       60

tccgtctttc tcttcccccc taagcccaag gataccctga tgatttcacg cactcctgag      120

gtaacttgcg tggtcgtaga tgttagccag gaagatccag aagttcagtt taattggtac      180

gttgatgggg tggaggtgca caatgccaaa actaaaccca gagaggaaca gttccagtct      240

acttatcgag tggttagcgt tctgaccgtc ctgcaccagg actggctgaa cggaaaggaa      300

tataaatgca aggtcagtaa caaggggctc cctagctcca tcgagaaaac gatatcaaaa      360

gcaaagggac agccaagaga gcctcaggtc tacactcttc ctccaagcca ggaagaaatg      420

accaaaaacc aggtttccct tacctgtctg gttaagggct tttacccatc cgatattgcg      480

gtggaatggg aatccaacgg tcaaccggaa aacaattaca agaccacccc tccggtcctg      540

gacagcgatg gaagtttttt tttgtattcc aggctcaccg tcgataaaag taggtggcag      600

gaaggaaacg tcttttcctg cagtgtgatg catgaagcgc tgcataatca ttatacacag      660

aagtccttga gtcttagcct cgggaaa                                          687


<210>  9
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 transmembrane domain

<400>  9
ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg       60

gcctttatta ttttctgggt g                                                 81


<210>  10
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 transmembrane domain aa

<400>  10

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  11
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 intracellular domain aa

<400>  11

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  12
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 intracellular domain

<400>  12
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc       60

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc      120

tcc                                                                    123


<210>  13
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta domain aa

<400>  13

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  14
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 zeta domain

<400>  14
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  15
<211>  553
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4hD29-28z CAR aa

<400>  15

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly 
            20                  25                  30          


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        35                  40                  45              


Gly Phe Thr Phe Ser Ser Asn Tyr Met Thr Trp Val Arg Gln Ala Pro 
    50                  55                  60                  


Gly Lys Gly Pro Glu Trp Val Ser Gly Ile Asn Pro Asp Gly Ser Ser 
65                  70                  75                  80  


Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                85                  90                  95      


Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu 
            100                 105                 110         


Asp Thr Ala Leu Tyr Lys Cys Ala Thr Gly Ala Ala Pro Arg Ile Pro 
        115                 120                 125             


Thr Thr Leu Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu Ser 
    130                 135                 140                 


Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Glu Gly 
145                 150                 155                 160 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                165                 170                 175     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
            180                 185                 190         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        195                 200                 205             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln Ser Thr Tyr 
    210                 215                 220                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
225                 230                 235                 240 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
                245                 250                 255     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            260                 265                 270         


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
        275                 280                 285             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    290                 295                 300                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
305                 310                 315                 320 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
                325                 330                 335     


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
            340                 345                 350         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        355                 360                 365             


Leu Gly Lys Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
    370                 375                 380                 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
385                 390                 395                 400 


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
                405                 410                 415     


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
            420                 425                 430         


Asp Phe Ala Ala Tyr Arg Ser Ile Asp Arg Val Lys Phe Ser Arg Ser 
        435                 440                 445             


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
    450                 455                 460                 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
465                 470                 475                 480 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
                485                 490                 495     


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
            500                 505                 510         


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
        515                 520                 525             


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
    530                 535                 540                 


Leu His Met Gln Ala Leu Pro Pro Arg 
545                 550             


<210>  16
<211>  1662
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4hD29-28z CAR

<400>  16
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggatccc aagtgcaact tcaagagtcc ggcggtggac ttgtccagcc aggagggagc      120

ctgcgacttt cctgcgccgc cagtgggttc acattttcca gtaattatat gacttgggta      180

cgacaggcac ctggcaaagg ccctgagtgg gtctcaggaa ttaacccgga tggttccagc      240

acatactacg cggattctgt taagggccgc tttaccatct caagggataa cgctaagaat      300

accctttatc tccagatgaa cagtctcaaa agcgaggaca ccgcattgta taaatgtgca      360

acaggggctg ctcctaggat tccaaccaca ttgagaggtc aaggcactca ggtgactgtc      420

tcctcagaga gcaagtacgg ccccccttgc cccagctgtc cggcaccaga gttcgaaggg      480

ggaccctccg tctttctctt cccccctaag cccaaggata ccctgatgat ttcacgcact      540

cctgaggtaa cttgcgtggt cgtagatgtt agccaggaag atccagaagt tcagtttaat      600

tggtacgttg atggggtgga ggtgcacaat gccaaaacta aacccagaga ggaacagttc      660

cagtctactt atcgagtggt tagcgttctg accgtcctgc accaggactg gctgaacgga      720

aaggaatata aatgcaaggt cagtaacaag gggctcccta gctccatcga gaaaacgata      780

tcaaaagcaa agggacagcc aagagagcct caggtctaca ctcttcctcc aagccaggaa      840

gaaatgacca aaaaccaggt ttcccttacc tgtctggtta agggctttta cccatccgat      900

attgcggtgg aatgggaatc caacggtcaa ccggaaaaca attacaagac cacccctccg      960

gtcctggaca gcgatggaag tttttttttg tattccaggc tcaccgtcga taaaagtagg     1020

tggcaggaag gaaacgtctt ttcctgcagt gtgatgcatg aagcgctgca taatcattat     1080

acacagaagt ccttgagtct tagcctcggg aaattttggg tgctggtggt ggttggtgga     1140

gtcctggctt gctatagctt gctagtaaca gtggccttta ttattttctg ggtgaggagt     1200

aagaggagca ggctcctgca cagtgactac atgaacatga ctccccgccg ccccgggccc     1260

acccgcaagc attaccagcc ctatgcccca ccacgcgact tcgcagccta tcgctccatc     1320

gatagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag     1380

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt     1440

ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac     1500

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag     1560

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac     1620

acctacgacg cccttcacat gcaggccctg ccccctcgct aa                        1662


<210>  17
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2hD1 nanobody aa

<400>  17

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Pro Tyr Gly Tyr Thr 
            20                  25                  30          


Phe Ser Ser Tyr Cys Met Arg Trp Phe Arg Gln Ala Pro Gly Lys Asp 
        35                  40                  45              


Arg Glu Gly Val Ala Arg Phe Glu Arg Asn Gly Leu Thr Thr Tyr Tyr 
    50                  55                  60                  


Asp Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Val Lys 
65                  70                  75                  80  


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
                85                  90                  95      


Thr Tyr Tyr Cys Ala Ala Ala Pro Lys Gln Leu Arg Thr Cys Gly Asp 
            100                 105                 110         


Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  18
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2hD1 nanobody

<400>  18
caggttcaat tgcaagagtc cggcggcggg cttgtgcaac caggcggcag cttgcgcctc       60

tcatgtgctg catccggtta cccatatggc tacacgttta gttcttactg tatgcgatgg      120

ttccggcagg cgcctgggaa ggatcgggaa ggggttgcta ggtttgaaag aaacggactt      180

accacttact atgacgactc cgttaaaggt agatttacta tatcccagga caatgtgaaa      240

aataccgtgt acttgcaaat gaatagcttg aaaccagagg acactgcaac atactattgc      300

gctgctgccc caaaacaact gaggacgtgt ggggattaca actattgggg gcaaggcact      360

caagtcactg tcagttct                                                    378


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2hD1 CDR1

<400>  19

Gly Tyr Thr Phe Ser Ser Tyr Cys 
1               5               


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2hD1 CDR2

<400>  20

Phe Glu Arg Asn Gly Leu Thr Thr 
1               5               


<210>  21
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2hD1 CDR3

<400>  21

Ala Ala Ala Pro Lys Gln Leu Arg Thr Cys Gly Asp Tyr Asn Tyr 
1               5                   10                  15  


<210>  22
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 hinge aa

<400>  22

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  23
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 hinge

<400>  23
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgat                                                       135


<210>  24
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2hD1-28z CAR aa

<400>  24

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly 
            20                  25                  30          


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        35                  40                  45              


Gly Tyr Pro Tyr Gly Tyr Thr Phe Ser Ser Tyr Cys Met Arg Trp Phe 
    50                  55                  60                  


Arg Gln Ala Pro Gly Lys Asp Arg Glu Gly Val Ala Arg Phe Glu Arg 
65                  70                  75                  80  


Asn Gly Leu Thr Thr Tyr Tyr Asp Asp Ser Val Lys Gly Arg Phe Thr 
                85                  90                  95      


Ile Ser Gln Asp Asn Val Lys Asn Thr Val Tyr Leu Gln Met Asn Ser 
            100                 105                 110         


Leu Lys Pro Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Ala Ala Pro Lys 
        115                 120                 125             


Gln Leu Arg Thr Cys Gly Asp Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
    130                 135                 140                 


Val Thr Val Ser Ser Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro 
145                 150                 155                 160 


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
                165                 170                 175     


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
            180                 185                 190         


Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
        195                 200                 205             


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
    210                 215                 220                 


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
225                 230                 235                 240 


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
                245                 250                 255     


Arg Asp Phe Ala Ala Tyr Arg Ser Ile Asp Arg Val Lys Phe Ser Arg 
            260                 265                 270         


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
        275                 280                 285             


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
    290                 295                 300                 


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
305                 310                 315                 320 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
                325                 330                 335     


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
            340                 345                 350         


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
        355                 360                 365             


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    370                 375             


<210>  25
<211>  1137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2hD1-28z CAR

<400>  25
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggatccc aggttcaatt gcaagagtcc ggcggcgggc ttgtgcaacc aggcggcagc      120

ttgcgcctct catgtgctgc atccggttac ccatatggct acacgtttag ttcttactgt      180

atgcgatggt tccggcaggc gcctgggaag gatcgggaag gggttgctag gtttgaaaga      240

aacggactta ccacttacta tgacgactcc gttaaaggta gatttactat atcccaggac      300

aatgtgaaaa ataccgtgta cttgcaaatg aatagcttga aaccagagga cactgcaaca      360

tactattgcg ctgctgcccc aaaacaactg aggacgtgtg gggattacaa ctattggggg      420

caaggcactc aagtcactgt cagttcttcc ggaaccacga cgccagcgcc gcgaccacca      480

acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc gcccagaggc gtgccggcca      540

gcggcggggg gcgcagtgca cacgaggggg ctggacttcg cctgtgattt ttgggtgctg      600

gtggtggttg gtggagtcct ggcttgctat agcttgctag taacagtggc ctttattatt      660

ttctgggtga ggagtaagag gagcaggctc ctgcacagtg actacatgaa catgactccc      720

cgccgccccg ggcccacccg caagcattac cagccctatg ccccaccacg cgacttcgca      780

gcctatcgct ccatcgatag agtgaagttc agcaggagcg cagacgcccc cgcgtaccag      840

cagggccaga accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt      900

ttggacaaga gacgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct      960

caggaaggcc tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt     1020

gggatgaaag gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt     1080

acagccacca aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgctaa        1137


<210>  26
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2hD6 nanobody aa

<400>  26

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Tyr Thr Tyr Ser Tyr Ser 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val 
        35                  40                  45              


Ala Ser Ile His Thr Gly Thr Gly Thr Ala Asn Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Ile Ala Ala Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Pro Gly Ser Ala Ala Leu Arg Cys Thr Thr Asp Tyr Ser 
            100                 105                 110         


Lys Pro His Asp Phe Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  27
<211>  390
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2hD6 nanobody

<400>  27
caggtccaac tccaggaatc cggtggtggg tctgtgcagg cagggggcag tctgaggttg       60

tcatgtgccg ctagttcata cacatactct tactcttgta tggcctggtt tcgacaggca      120

cccggcaaag agcgggagag agttgccagc attcacacag gaactggaac cgccaattat      180

gcagattctg ctaagggtcg gtttacaata agccaggata ttgcagcgaa taccgtatat      240

ttgcaaatga acagccttaa gctcgaagat actgcaatgt attactgcgc tgcacgacca      300

gggtctgctg cccttaggtg tacgactgat tatagcaagc cgcatgattt tacttactgg      360

gggcagggga cacaggttac tgtatcctct                                       390


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2hD6 CDR1

<400>  28

Ser Tyr Thr Tyr Ser Tyr Ser Cys 
1               5               


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2hD6 CDR2

<400>  29

Ile His Thr Gly Thr Gly Thr Ala 
1               5               


<210>  30
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2hD6 CDR3

<400>  30

Ala Ala Arg Pro Gly Ser Ala Ala Leu Arg Cys Thr Thr Asp Tyr Ser 
1               5                   10                  15      


Lys Pro His Asp Phe Thr Tyr 
            20              


<210>  31
<211>  382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2hD6-28z CAR aa

<400>  31

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly 
            20                  25                  30          


Gly Ser Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        35                  40                  45              


Ser Tyr Thr Tyr Ser Tyr Ser Cys Met Ala Trp Phe Arg Gln Ala Pro 
    50                  55                  60                  


Gly Lys Glu Arg Glu Arg Val Ala Ser Ile His Thr Gly Thr Gly Thr 
65                  70                  75                  80  


Ala Asn Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Gln Asp 
                85                  90                  95      


Ile Ala Ala Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Leu Glu 
            100                 105                 110         


Asp Thr Ala Met Tyr Tyr Cys Ala Ala Arg Pro Gly Ser Ala Ala Leu 
        115                 120                 125             


Arg Cys Thr Thr Asp Tyr Ser Lys Pro His Asp Phe Thr Tyr Trp Gly 
    130                 135                 140                 


Gln Gly Thr Gln Val Thr Val Ser Ser Ser Gly Thr Thr Thr Pro Ala 
145                 150                 155                 160 


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
                165                 170                 175     


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
            180                 185                 190         


Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly 
        195                 200                 205             


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
    210                 215                 220                 


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
225                 230                 235                 240 


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
                245                 250                 255     


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Ile Asp Arg Val 
            260                 265                 270         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        275                 280                 285             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    290                 295                 300                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
305                 310                 315                 320 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                325                 330                 335     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            340                 345                 350         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        355                 360                 365             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    370                 375                 380         


<210>  32
<211>  1149
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2hD6-28z CAR

<400>  32
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggatccc aggtccaact ccaggaatcc ggtggtgggt ctgtgcaggc agggggcagt      120

ctgaggttgt catgtgccgc tagttcatac acatactctt actcttgtat ggcctggttt      180

cgacaggcac ccggcaaaga gcgggagaga gttgccagca ttcacacagg aactggaacc      240

gccaattatg cagattctgc taagggtcgg tttacaataa gccaggatat tgcagcgaat      300

accgtatatt tgcaaatgaa cagccttaag ctcgaagata ctgcaatgta ttactgcgct      360

gcacgaccag ggtctgctgc ccttaggtgt acgactgatt atagcaagcc gcatgatttt      420

acttactggg ggcaggggac acaggttact gtatcctctt ccggaaccac gacgccagcg      480

ccgcgaccac caacaccggc gcccaccatc gcgtcgcagc ccctgtccct gcgcccagag      540

gcgtgccggc cagcggcggg gggcgcagtg cacacgaggg ggctggactt cgcctgtgat      600

ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg      660

gcctttatta ttttctgggt gaggagtaag aggagcaggc tcctgcacag tgactacatg      720

aacatgactc cccgccgccc cgggcccacc cgcaagcatt accagcccta tgccccacca      780

cgcgacttcg cagcctatcg ctccatcgat agagtgaagt tcagcaggag cgcagacgcc      840

cccgcgtacc agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag      900

gagtacgatg ttttggacaa gagacgtggc cgggaccctg agatgggggg aaagccgaga      960

aggaagaacc ctcaggaagg cctgtacaat gaactgcaga aagataagat ggcggaggcc     1020

tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggcctttac     1080

cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc     1140

cctcgctaa                                                             1149


<210>  33
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2hD38 nanobody aa

<400>  33

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Asn Thr Gln Gly Asn Tyr 
            20                  25                  30          


Cys Leu Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Gly Gly Ile Lys Thr Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Thr Ser Val Thr Cys Phe Ala Ser Ser Trp Ala Arg Leu 
            100                 105                 110         


Asn Ala Tyr Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  34
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2hD38 nanobody

<400>  34
caggtgcaac ttcaagaatc aggagggggt tccgttcaag ccggtgggtc actgaggctt       60

tcttgcgctg cttcagaaaa cactcagggc aactactgcc tcgcgtggtt tcgacaagca      120

ccagggaagg aacgggaagg agtggcttcc ataagcagcg gaggaatcaa aacatactac      180

gctgacaccg ttaagggccg gttcaccatc agccgcgata atgccgaaaa tactgtgtac      240

ttgcagatga attccctcaa accagaggat acggctattt actactgtgc agcacggacc      300

agcgtgacct gcttcgcctc ctcatgggct aggctcaacg cttacgccta ttggggacag      360

ggaactcagg tcacagtaag cagc                                             384


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2hD38 CDR1

<400>  35

Glu Asn Thr Gln Gly Asn Tyr Cys 
1               5               


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2hD38 CDR2

<400>  36

Ile Ser Ser Gly Gly Ile Lys Thr 
1               5               


<210>  37
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2hD38 CDR3

<400>  37

Ala Ala Arg Thr Ser Val Thr Cys Phe Ala Ser Ser Trp Ala Arg Leu 
1               5                   10                  15      


Asn Ala Tyr Ala Tyr 
            20      


<210>  38
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2hD38-28z CAR aa

<400>  38

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly 
            20                  25                  30          


Gly Ser Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        35                  40                  45              


Glu Asn Thr Gln Gly Asn Tyr Cys Leu Ala Trp Phe Arg Gln Ala Pro 
    50                  55                  60                  


Gly Lys Glu Arg Glu Gly Val Ala Ser Ile Ser Ser Gly Gly Ile Lys 
65                  70                  75                  80  


Thr Tyr Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                85                  90                  95      


Asn Ala Glu Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
            100                 105                 110         


Asp Thr Ala Ile Tyr Tyr Cys Ala Ala Arg Thr Ser Val Thr Cys Phe 
        115                 120                 125             


Ala Ser Ser Trp Ala Arg Leu Asn Ala Tyr Ala Tyr Trp Gly Gln Gly 
    130                 135                 140                 


Thr Gln Val Thr Val Ser Ser Ser Gly Thr Thr Thr Pro Ala Pro Arg 
145                 150                 155                 160 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
                165                 170                 175     


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
            180                 185                 190         


Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val 
        195                 200                 205             


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
    210                 215                 220                 


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
225                 230                 235                 240 


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
                245                 250                 255     


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Ile Asp Arg Val Lys Phe 
            260                 265                 270         


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
        275                 280                 285             


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
    290                 295                 300                 


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
305                 310                 315                 320 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
                325                 330                 335     


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
            340                 345                 350         


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
        355                 360                 365             


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    370                 375                 380 


<210>  39
<211>  1143
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2hD38-28z CAR

<400>  39
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggatccc aggtgcaact tcaagaatca ggagggggtt ccgttcaagc cggtgggtca      120

ctgaggcttt cttgcgctgc ttcagaaaac actcagggca actactgcct cgcgtggttt      180

cgacaagcac cagggaagga acgggaagga gtggcttcca taagcagcgg aggaatcaaa      240

acatactacg ctgacaccgt taagggccgg ttcaccatca gccgcgataa tgccgaaaat      300

actgtgtact tgcagatgaa ttccctcaaa ccagaggata cggctattta ctactgtgca      360

gcacggacca gcgtgacctg cttcgcctcc tcatgggcta ggctcaacgc ttacgcctat      420

tggggacagg gaactcaggt cacagtaagc agctccggaa ccacgacgcc agcgccgcga      480

ccaccaacac cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc      540

cggccagcgg cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatttttgg      600

gtgctggtgg tggttggtgg agtcctggct tgctatagct tgctagtaac agtggccttt      660

attattttct gggtgaggag taagaggagc aggctcctgc acagtgacta catgaacatg      720

actccccgcc gccccgggcc cacccgcaag cattaccagc cctatgcccc accacgcgac      780

ttcgcagcct atcgctccat cgatagagtg aagttcagca ggagcgcaga cgcccccgcg      840

taccagcagg gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac      900

gatgttttgg acaagagacg tggccgggac cctgagatgg ggggaaagcc gagaaggaag      960

aaccctcagg aaggcctgta caatgaactg cagaaagata agatggcgga ggcctacagt     1020

gagattggga tgaaaggcga gcgccggagg ggcaaggggc acgatggcct ttaccagggt     1080

ctcagtacag ccaccaagga cacctacgac gcccttcaca tgcaggccct gccccctcgc     1140

taa                                                                   1143


<210>  40
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  40

Gly Ser Gly Gly Ser 
1               5   


<210>  41
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  41

Gly Gly Gly Ser 
1               


<210>  42
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  42

Gly Gly Gly Gly Ser 
1               5   


<210>  43
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  43

Gly Gly Ser Gly 
1               


<210>  44
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  44

Gly Gly Ser Gly Gly 
1               5   


<210>  45
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  45

Gly Ser Gly Ser Gly 
1               5   


<210>  46
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  46

Gly Ser Gly Gly Gly 
1               5   


<210>  47
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  47

Gly Gly Gly Ser Gly 
1               5   


<210>  48
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  48

Gly Ser Ser Ser Gly 
1               5   


<210>  49
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  49

Gly Gly Gly Gly Ser 
1               5   


<210>  50
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  50

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  51
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  51

Gly Gly Thr Gly Gly Cys Gly Gly Thr Gly Gly Cys Thr Cys Gly Gly 
1               5                   10                  15      


Gly Cys Gly Gly Thr Gly Gly Thr Gly Gly Gly Thr Cys Gly Gly Gly 
            20                  25                  30          


Thr Gly Gly Cys Gly Gly Cys Gly Gly Ala Thr Cys Thr 
        35                  40                  45  


<210>  52
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  52

Asp Lys Thr His Thr 
1               5   


<210>  53
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  53

Cys Pro Pro Cys 
1               


<210>  54
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  54

Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
1               5                   10                  15  


<210>  55
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  55

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
1               5                   10          


<210>  56
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  56

Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
1               5                   10  


<210>  57
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  57

Lys Cys Cys Val Asp Cys Pro 
1               5           


<210>  58
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  58

Lys Tyr Gly Pro Pro Cys Pro 
1               5           


<210>  59
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  59

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  60
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  60

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210>  61
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  61

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro 
    


<210>  62
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  62

Ser Pro Asn Met Val Pro His Ala His His Ala Gln 
1               5                   10          


<210>  63
<211>  1515
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huFAP CAR

<400>  63
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggcagcg acatcgtgat gagccagagc cccagcagcc tggccgtgtc cgtgggcgag      120

aaagtgacca tgagctgcaa gagcagccag agcctgctgt acagccggaa ccagaagaac      180

tacctggcct ggttccagca gaagcccggc cagtccccca agctgctgat cttctgggcc      240

agcacccgcg agagcggcgt gccagataga ttcaccggca gcggcttcgg caccgacttc      300

aacctgacca tcagcagcgt gcaggccgag gatctggccg tgtacgactg ccagcagtac      360

ttcagctacc ccctgacctt cggagccggc accaagctgg aactgaaggg cggaggcggc      420

tctggcggcg gaggaagttc tggcggaggc tctgaggtgc agctgcagca gagcggccct      480

gagctggtga aacctggcgc cagcgtgaag atgtcctgca agaccagccg gtacaccttc      540

accgagtaca ccatccactg ggtgcgccag tctcacggca agagcctgga atggatcggc      600

ggcatcaacc ccaacaacgg catccccaac tacaaccaga agttcaaggg cagagccacc      660

ctgaccgtgg gcaagtccag cagcaccgcc tacatggaac tgcggagcct gaccagcgag      720

gacagcgctg tgtacttctg cgccagacgg cggatcgcct acggctatga cgagggccac      780

gccatggact actggggaca gggcaccagc gtgaccgtgt ctagctccgg aaccacgacg      840

ccagcgccgc gaccaccaac accggcgccc accatcgcgt cgcagcccct gtccctgcgc      900

ccagaggcgt gccggccagc ggcggggggc gcagtgcaca cgagggggct ggacttcgcc      960

tgtgattttt gggtgctggt ggtggttggt ggagtcctgg cttgctatag cttgctagta     1020

acagtggcct ttattatttt ctgggtgagg agtaagagga gcaggctcct gcacagtgac     1080

tacatgaaca tgactccccg ccgccccggg cccacccgca agcattacca gccctatgcc     1140

ccaccacgcg acttcgcagc ctatcgctcc atcgatagag tgaagttcag caggagcgca     1200

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     1260

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1320

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     1380

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1440

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     1500

ctgccccctc gctaa                                                      1515


<210>  64
<211>  756
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huFAP-F19-L2H scFv

<400>  64
gacatcgtga tgagccagag ccccagcagc ctggccgtgt ccgtgggcga gaaagtgacc       60

atgagctgca agagcagcca gagcctgctg tacagccgga accagaagaa ctacctggcc      120

tggttccagc agaagcccgg ccagtccccc aagctgctga tcttctgggc cagcacccgc      180

gagagcggcg tgccagatag attcaccggc agcggcttcg gcaccgactt caacctgacc      240

atcagcagcg tgcaggccga ggatctggcc gtgtacgact gccagcagta cttcagctac      300

cccctgacct tcggagccgg caccaagctg gaactgaagg gcggaggcgg ctctggcggc      360

ggaggaagtt ctggcggagg ctctgaggtg cagctgcagc agagcggccc tgagctggtg      420

aaacctggcg ccagcgtgaa gatgtcctgc aagaccagcc ggtacacctt caccgagtac      480

accatccact gggtgcgcca gtctcacggc aagagcctgg aatggatcgg cggcatcaac      540

cccaacaacg gcatccccaa ctacaaccag aagttcaagg gcagagccac cctgaccgtg      600

ggcaagtcca gcagcaccgc ctacatggaa ctgcggagcc tgaccagcga ggacagcgct      660

gtgtacttct gcgccagacg gcggatcgcc tacggctatg acgagggcca cgccatggac      720

tactggggac agggcaccag cgtgaccgtg tctagc                                756


