                         SEQUENCE LISTING

<110>  Biotempt B.V.
 
<120>  Chemotactic autophagy-inhibiting peptide, compositions and 
       methods related thereto.

<130>  P129548PC00

<140>  PCT/NL2022/050115
<141>  2022-03-02

<150>  EP 21160152.1
<151>  2021-03-02

<160>  82    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  1

Ile Ser His Lys Asp Met Gln Leu Gly Arg 
1               5                   10  


<210>  2
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  constrained human C5a analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  is D-ala

<400>  2

Tyr Ser Phe Lys Pro Met Pro Leu Xaa Arg 
1               5                   10  


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  unconstrained sister analog C5a65-74465, F67++

<400>  3

Tyr Ser Phe Lys Asp Met Gln Leu Gly Arg 
1               5                   10  


<210>  4
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 partial agonist

<400>  4

Arg Ser Val Met 
1               


<210>  5
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 superagonist

<400>  5

Ala Ser Leu Trp 
1               


<210>  6
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FPR agonist


<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  is D-Met

<400>  6

Trp Lys Tyr Met Val Xaa 
1               5       


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPGPH

<400>  7

Pro Pro Gly Pro His 
1               5   


<210>  8
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  part of IL-8 sequence

<400>  8

Glu Ser Gly Pro His 
1               5   


<210>  9
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  analog of WKYMVm

<400>  9

Trp Arg Trp Trp Trp Trp 
1               5       


<210>  10
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tetrapeptide

<400>  10

Leu Gln Gly Val 
1               


<210>  11
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tetrapeptide

<400>  11

Ala Gln Gly Val 
1               


<210>  12
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  autophagy-inhibiting peptide

<400>  12

Leu Pro Asp Ile Ser Leu Lys Asp Leu Gln Phe Leu Gln Ser Phe Cys 
1               5                   10                  15      


Pro Ser Glu Val Gln 
            20      


<210>  13
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG-domain amino acid motif


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa can be any amino acid

<220>
<221>  VARIANT
<222>  (3)..(4)
<223>  Xaa can be any amino acid

<400>  13

Xaa Gly Xaa Xaa Pro Gly 
1               5       


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemoattractant motif


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  is D-ala

<400>  14

Tyr Ser Phe Lys Pro Met Pro Leu Xaa Arg 
1               5                   10  


<210>  15
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  molecule specifically recognizing an CXC receptor


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  X is an autophagy inhibiting amino acid

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  X = 1-23 autophagy inhibiting amino acid(s)

<400>  15

Xaa Pro Gly Xaa 
1               


<210>  16
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  molecule specifically recognizing an CXC receptor


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  X = 1-24 autophagy inhibiting amino acid(s)

<400>  16

Xaa Pro Gly Pro 
1               


<210>  17
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  molecule specifically recognizing an CXC receptor


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  X = 1-24 autophagy inhibiting amino acid(s)

<400>  17

Pro Gly Pro Xaa 
1               


<210>  18
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  molecule specifically recognizing an CXC receptor


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  X is an autophagy inhibiting amino acid

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  X = 1-23 autophagy inhibiting amino acid(s)

<400>  18

Xaa Pro Gly Pro Xaa 
1               5   


<210>  19
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemoattractant motif comprising autophagy-inhibiting peptide


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  X is no amino acid or Xaa can be any amino acid

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  X is no amino acid or Xaa can be any amino acid

<400>  19

Xaa Pro Gly Pro Xaa 
1               5   


<210>  20
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemoattractant motif comprising autophagy-inhibiting peptide


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa can be any amino acid

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa can be any amino acid

<400>  20

Xaa Pro Gly Pro Xaa 
1               5   


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  21

Ala Gln Gly Val Ala Pro Gly Gln 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  22

Leu Gln Gly Val Ala Pro Gly Gln 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  23

Ala Gln Gly Val Leu Pro Gly Gln 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  24

Leu Gln Gly Val Leu Pro Gly Gln 
1               5               


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  25

Ala Gln Gly Gln Ala Pro Gly Gln 
1               5               


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  26

Leu Gln Gly Gln Ala Pro Gly Gln 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  27

Ala Gln Gly Gln Leu Pro Gly Gln 
1               5               


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  28

Leu Gln Gly Gln Leu Pro Gly Gln 
1               5               


<210>  29
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bacteria-derived N-formyl peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  FORMYLATION

<400>  29

Met Ile Phe Leu 
1               


<210>  30
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bacteria-derived N-formyl peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  FORMYLATION

<400>  30

Met Ile Val Ile Leu 
1               5   


<210>  31
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bacteria-derived N-formyl peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  FORMYLATION

<400>  31

Met Ile Gly Trp Ile 
1               5   


<210>  32
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bacteria-derived N-formyl peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  FORMYLATION

<400>  32

Met Ile Val Thr Leu Phe 
1               5       


<210>  33
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bacteria-derived N-formyl peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  FORMYLATION

<400>  33

Met Ile Gly Trp Ile Ile 
1               5       


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bacteria-derived N-formyl peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  FORMYLATION

<400>  34

Met Phe Glu Asp Ala Val Ala Trp Phe 
1               5                   


<210>  35
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mitochondria-derived N-formyl peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  FORMYLATION

<400>  35

Met Met Tyr Ala Leu Phe 
1               5       


<210>  36
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mitochondria-derived N-formyl peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  FORMYLATION

<400>  36

Met Leu Lys Leu Ile Val 
1               5       


<210>  37
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mitochondria-derived N-formyl peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  FORMYLATION

<400>  37

Met Tyr Phe Ile Asn Ile Leu Thr Leu 
1               5                   


<210>  38
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mitochondria-derived N-formyl peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  FORMYLATION

<400>  38

Met Phe Ala Asp Arg Trp 
1               5       


<210>  39
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mitochondria-derived N-formyl peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Nle

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  FORMYLATION

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Nle

<400>  39

Xaa Leu Phe Xaa Tyr Lys 
1               5       


<210>  40
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Host-derived peptide D2D3


<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  is D-Pro

<400>  40

Ser Arg Ser Arg Tyr Xaa 
1               5       


<210>  41
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Agonist from peptide library

<400>  41

Trp Lys Tyr Met Val Met 
1               5       


<210>  42
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Agonist from peptide library

<400>  42

Met Met Trp Leu Leu 
1               5   


<210>  43
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Agonist from peptide library


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  FORMYLATION

<400>  43

Met Met Trp Leu Leu 
1               5   


<210>  44
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  formyl-peptide receptor binding motif


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  FORMYLATION

<400>  44

Met Ile Val Thr Phe Leu 
1               5       


<210>  45
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  formyl-peptide receptor binding motif


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  FORMYLATION

<400>  45

Met Tyr Val Lys Trp Pro Trp Tyr Val Trp Leu 
1               5                   10      


<210>  46
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  formyl-peptide receptor binding motif

<400>  46

Leu Glu Ser Ile Phe Arg Ser Leu Leu Phe Arg Val Met 
1               5                   10              


<210>  47
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  formyl-peptide receptor binding motif

<400>  47

Lys Trp Pro Trp Tyr Val Trp Leu 
1               5               


<210>  48
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  formyl-peptide receptor binding motif

<400>  48

Lys Trp Pro Trp Tyr Ile Trp Leu 
1               5               


<210>  49
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  formyl-peptide receptor binding motif

<400>  49

Lys Trp Pro Trp Trp Val Trp Leu 
1               5               


<210>  50
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  formyl-peptide receptor binding motif

<400>  50

Lys Trp Pro Trp Trp Ile Trp Leu 
1               5               


<210>  51
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  autophagy-inhibiting-peptide

<400>  51

Gln Gln Gly Val 
1               


<210>  52
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  autophagy-inhibiting-peptide

<400>  52

Leu Gln Gly Val 
1               


<210>  53
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  autophagy-inhibiting-peptide

<400>  53

Gly Gln Gly Val 
1               


<210>  54
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  autophagy-inhibiting-peptide

<400>  54

Pro Gln Gly Val 
1               


<210>  55
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  autophagy-inhibiting-peptide

<400>  55

Val Gln Gly Val 
1               


<210>  56
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  autophagy-inhibiting-peptide

<400>  56

Ala Leu Gly Val 
1               


<210>  57
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  autophagy-inhibiting-peptide

<400>  57

Leu Leu Gly Val 
1               


<210>  58
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  autophagy-inhibiting-peptide

<400>  58

Gln Leu Gly Val 
1               


<210>  59
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  autophagy-inhibiting-peptide

<400>  59

Gly Leu Gly Val 
1               


<210>  60
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  autophagy-inhibiting-peptide

<400>  60

Pro Leu Gly Val 
1               


<210>  61
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  autophagy-inhibiting-peptide

<400>  61

Val Leu Gly Val 
1               


<210>  62
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  autophagy-inhibiting-peptide

<400>  62

Gln Ala Gly Val 
1               


<210>  63
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  autophagy-inhibiting-peptide

<400>  63

Gln Leu Gly Val 
1               


<210>  64
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  autophagy-inhibiting-peptide

<400>  64

Gln Gly Gly Val 
1               


<210>  65
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  autophagy-inhibiting-peptide

<400>  65

Gln Pro Gly Val 
1               


<210>  66
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  autophagy-inhibiting-peptide

<400>  66

Gln Val Gly Val 
1               


<210>  67
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  autophagy-inhibiting-peptide

<400>  67

Leu Ala Gly Val 
1               


<210>  68
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  autophagy-inhibiting-peptide

<400>  68

Leu Gly Gly Val 
1               


<210>  69
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  autophagy-inhibiting-peptide

<400>  69

Leu Pro Gly Val 
1               


<210>  70
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  autophagy-inhibiting-peptide

<400>  70

Leu Val Gly Val 
1               


<210>  71
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  71

Lys Trp Pro Trp Tyr Ile Trp Leu Ala Gln Gly Val 
1               5                   10          


<210>  72
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  72

Lys Trp Pro Trp Tyr Ile Trp Leu Ala Gln Leu Pro Gly Pro 
1               5                   10                  


<210>  73
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  73

Lys Trp Pro Trp Tyr Ile Trp Leu Gln Gly Val Leu Pro Ala Leu Pro 
1               5                   10                  15      


<210>  74
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  74

Lys Trp Pro Trp Tyr Ile Trp Leu Gln Gly Leu Gln Pro Gly Gln 
1               5                   10                  15  


<210>  75
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  75

Trp Pro Trp Tyr Ile Trp Leu Gln Gly Leu Gln Pro Gly Gln 
1               5                   10                  


<210>  76
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  FORMYLATION

<400>  76

Met Leu Phe Leu Gln Gly Leu Gln Pro Gly Gln 
1               5                   10      


<210>  77
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  77

Pro Gly Pro Ala Gln Gly Leu Gln Pro Gly Gln 
1               5                   10      


<210>  78
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  78

Pro Gly Pro Leu Gln Gly Leu Gln Pro Gly Gln 
1               5                   10      


<210>  79
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  79

Pro Gly Pro Ala Gln Gly Val Ala Pro Gly Pro 
1               5                   10      


<210>  80
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  FORMYLATION

<400>  80

Met Leu Phe Leu Gln Gly Val Ala Pro Gly Pro 
1               5                   10      


<210>  81
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  is D-Ala

<400>  81

Tyr Ser Phe Lys Pro Met Pro Leu Xaa Arg Ala Gln Gly Val Leu Pro 
1               5                   10                  15      


Gly 
    


<210>  82
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  is D-Ala

<400>  82

Tyr Ser Phe Lys Pro Met Pro Leu Xaa Arg Ala Gln Gly Val Leu Pro 
1               5                   10                  15      


Gly Leu Gln Gly Val Leu Pro Gly 
            20                  


