                         SEQUENCE LISTING

<110>  Technion Research and Development Foundation Ltd.
 
<120>  UBIQUITIN LIGASE KPC1-PEPTIDE BASED PROTEOLYSIS TARGETING 
       CHIMERAS (PROTAC) AND USES THEREOF

<130>  2850680-JDB

<150>  US 63/156,188
<151>  2021-03-03

<150>  US 63/324,071
<151>  2021-09-22

<160>  68    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus of NF-kappaB1 p105 targeting/ recruiting component


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid repeated n times, wherein n is zero or an 
       integer between 1 to 7

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa may be Phe, Trp or Tyr

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is repeated m times, wherein m is an integer between 1 to 7

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa may be Phe, Trp or Tyr

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is repeated n times, wherein n is zero or an integer between 
       1 to 7

<400>  1

Xaa Xaa Xaa Xaa Xaa 
1               5   


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component

<400>  2

Arg Ile Trp Val Trp Leu Leu 
1               5           


<210>  3
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component

<400>  3

Ile Trp Val Trp Leu Leu 
1               5       


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KPC1-derived (residues 968-974) NF-kappaB1 p105 
       targeting/recruiting component

<400>  4

Trp Ile Leu Val Arg Leu Trp 
1               5           


<210>  5
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KPC1-derived (residues 969-974) peptide

<400>  5

Ile Leu Val Arg Leu Trp 
1               5       


<210>  6
<211>  1314
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Ser Lys Gly Ala Gly Met Ser Phe Ser Arg Lys Ser Tyr Arg 
1               5                   10                  15      


Leu Thr Ser Asp Ala Glu Lys Ser Arg Val Thr Gly Ile Val Gln Glu 
            20                  25                  30          


Lys Leu Leu Asn Asp Tyr Leu Asn Arg Ile Phe Ser Ser Ser Glu His 
        35                  40                  45              


Ala Pro Pro Ala Ala Thr Ser Arg Lys Pro Leu Asn Phe Gln Asn Leu 
    50                  55                  60                  


Pro Glu His Leu Asp Gln Leu Leu Gln Val Asp Asn Glu Glu Glu Glu 
65                  70                  75                  80  


Ser Gln Gly Gln Val Glu Gly Arg Leu Gly Pro Ser Thr Val Val Leu 
                85                  90                  95      


Asp His Thr Gly Gly Phe Glu Gly Leu Leu Leu Val Asp Asp Asp Leu 
            100                 105                 110         


Leu Gly Val Ile Gly His Ser Asn Phe Gly Thr Ile Arg Ser Thr Thr 
        115                 120                 125             


Cys Val Tyr Lys Gly Lys Trp Leu Tyr Glu Val Leu Ile Ser Ser Gln 
    130                 135                 140                 


Gly Leu Met Gln Ile Gly Trp Cys Thr Ile Ser Cys Arg Phe Asn Gln 
145                 150                 155                 160 


Glu Glu Gly Val Gly Asp Thr His Asn Ser Tyr Ala Tyr Asp Gly Asn 
                165                 170                 175     


Arg Val Arg Lys Trp Asn Val Thr Thr Thr Asn Tyr Gly Lys Ala Trp 
            180                 185                 190         


Ala Ala Gly Asp Ile Val Ser Cys Leu Ile Asp Leu Asp Asp Gly Thr 
        195                 200                 205             


Leu Ser Phe Cys Leu Asn Gly Val Ser Leu Gly Thr Ala Phe Glu Asn 
    210                 215                 220                 


Leu Ser Arg Gly Leu Gly Met Ala Tyr Phe Pro Ala Ile Ser Leu Ser 
225                 230                 235                 240 


Phe Lys Glu Ser Val Ala Phe Asn Phe Gly Ser Arg Pro Leu Arg Tyr 
                245                 250                 255     


Pro Val Ala Gly Tyr Arg Pro Leu Gln Asp Pro Pro Ser Ala Asp Leu 
            260                 265                 270         


Val Arg Ala Gln Arg Leu Leu Gly Cys Phe Arg Ala Val Leu Ser Val 
        275                 280                 285             


Glu Leu Asp Pro Val Glu Gly Arg Leu Leu Asp Lys Glu Ser Ser Lys 
    290                 295                 300                 


Trp Arg Leu Arg Gly Gln Pro Thr Val Leu Leu Thr Leu Ala His Ile 
305                 310                 315                 320 


Phe His His Phe Ala Pro Leu Leu Arg Lys Val Tyr Leu Val Glu Ala 
                325                 330                 335     


Val Leu Met Ser Phe Leu Leu Gly Ile Val Glu Lys Gly Thr Pro Thr 
            340                 345                 350         


Gln Ala Gln Ser Val Val His Gln Val Leu Asp Leu Leu Trp Leu Phe 
        355                 360                 365             


Met Glu Asp Tyr Glu Val Gln Asp Cys Leu Lys Gln Leu Met Met Ser 
    370                 375                 380                 


Leu Leu Arg Leu Tyr Arg Phe Ser Pro Ile Val Pro Asp Leu Gly Leu 
385                 390                 395                 400 


Gln Ile His Tyr Leu Arg Leu Thr Ile Ala Ile Leu Arg His Glu Lys 
                405                 410                 415     


Ser Arg Lys Phe Leu Leu Ser Asn Val Leu Phe Asp Val Leu Arg Ser 
            420                 425                 430         


Val Val Phe Phe Tyr Ile Lys Ser Pro Leu Arg Val Glu Glu Ala Gly 
        435                 440                 445             


Leu Gln Glu Leu Ile Pro Thr Thr Trp Trp Pro His Cys Ser Ser Arg 
    450                 455                 460                 


Glu Gly Lys Glu Ser Thr Glu Met Lys Glu Glu Thr Ala Glu Glu Arg 
465                 470                 475                 480 


Leu Arg Arg Arg Ala Tyr Glu Arg Gly Cys Gln Arg Leu Arg Lys Arg 
                485                 490                 495     


Ile Glu Val Val Glu Glu Leu Gln Val Gln Ile Leu Lys Leu Leu Leu 
            500                 505                 510         


Asp Asn Lys Asp Asp Asn Gly Gly Glu Ala Ser Arg Tyr Ile Phe Leu 
        515                 520                 525             


Thr Lys Phe Arg Lys Phe Leu Gln Glu Asn Ala Ser Gly Arg Gly Asn 
    530                 535                 540                 


Met Pro Met Leu Cys Pro Pro Glu Tyr Met Val Cys Phe Leu His Arg 
545                 550                 555                 560 


Leu Ile Ser Ala Leu Arg Tyr Tyr Trp Asp Glu Tyr Lys Ala Ser Asn 
                565                 570                 575     


Pro His Ala Ser Phe Ser Glu Glu Ala Tyr Ile Pro Pro Gln Val Phe 
            580                 585                 590         


Tyr Asn Gly Lys Val Asp Tyr Phe Asp Leu Gln Arg Leu Gly Gly Leu 
        595                 600                 605             


Leu Ser His Leu Arg Lys Thr Leu Lys Asp Asp Leu Ala Ser Lys Ala 
    610                 615                 620                 


Asn Ile Val Ile Asp Pro Leu Glu Leu Gln Ser Thr Ala Met Asp Asp 
625                 630                 635                 640 


Leu Asp Glu Asp Glu Glu Pro Ala Pro Ala Met Ala Gln Arg Pro Met 
                645                 650                 655     


Gln Ala Leu Ala Val Gly Gly Pro Leu Pro Leu Pro Arg Pro Gly Trp 
            660                 665                 670         


Leu Ser Ser Pro Thr Leu Gly Arg Ala Asn Arg Phe Leu Ser Thr Ala 
        675                 680                 685             


Ala Val Ser Leu Met Thr Pro Arg Arg Pro Leu Ser Thr Ser Glu Lys 
    690                 695                 700                 


Val Lys Val Arg Thr Leu Ser Val Glu Gln Arg Thr Arg Glu Asp Ile 
705                 710                 715                 720 


Glu Gly Ser His Trp Asn Glu Gly Leu Leu Leu Gly Arg Pro Pro Glu 
                725                 730                 735     


Glu Pro Glu Gln Pro Leu Thr Glu Asn Ser Leu Leu Glu Val Leu Asp 
            740                 745                 750         


Gly Ala Val Met Met Tyr Asn Leu Ser Val His Gln Gln Leu Gly Lys 
        755                 760                 765             


Met Val Gly Val Ser Asp Asp Val Asn Glu Tyr Ala Met Ala Leu Arg 
    770                 775                 780                 


Asp Thr Glu Asp Lys Leu Arg Arg Cys Pro Lys Arg Arg Lys Asp Ile 
785                 790                 795                 800 


Leu Ala Glu Leu Thr Lys Ser Gln Lys Val Phe Ser Glu Lys Leu Asp 
                805                 810                 815     


His Leu Ser Arg Arg Leu Ala Trp Val His Ala Thr Val Tyr Ser Gln 
            820                 825                 830         


Glu Lys Met Leu Asp Ile Tyr Trp Leu Leu Arg Val Cys Leu Arg Thr 
        835                 840                 845             


Ile Glu His Gly Asp Arg Thr Gly Ser Leu Phe Ala Phe Met Pro Glu 
    850                 855                 860                 


Phe Tyr Leu Ser Val Ala Ile Asn Ser Tyr Ser Ala Leu Lys Asn Tyr 
865                 870                 875                 880 


Phe Gly Pro Val His Ser Met Glu Glu Leu Pro Gly Tyr Glu Glu Thr 
                885                 890                 895     


Leu Thr Arg Leu Ala Ala Ile Leu Ala Lys His Phe Ala Asp Ala Arg 
            900                 905                 910         


Ile Val Gly Thr Asp Ile Arg Asp Ser Leu Met Gln Ala Leu Ala Ser 
        915                 920                 925             


Tyr Val Cys Tyr Pro His Ser Leu Arg Ala Val Glu Arg Ile Pro Glu 
    930                 935                 940                 


Glu Gln Arg Ile Ala Met Val Arg Asn Leu Leu Ala Pro Tyr Glu Gln 
945                 950                 955                 960 


Arg Pro Trp Ala Gln Thr Asn Trp Ile Leu Val Arg Leu Trp Arg Gly 
                965                 970                 975     


Cys Gly Phe Gly Tyr Arg Tyr Thr Arg Leu Pro His Leu Leu Lys Thr 
            980                 985                 990         


Lys Leu Glu Asp Ala Asn Leu Pro  Ser Leu Gln Lys Pro  Cys Pro Ser 
        995                 1000                 1005             


Thr Leu  Leu Gln Gln His Met  Ala Asp Leu Leu Gln  Gln Gly Pro 
    1010                 1015                 1020             


Asp Val  Ala Pro Ser Phe Leu  Asn Ser Val Leu Asn  Gln Leu Asn 
    1025                 1030                 1035             


Trp Ala  Phe Ser Glu Phe Ile  Gly Met Ile Gln Glu  Ile Gln Gln 
    1040                 1045                 1050             


Ala Ala  Glu Arg Leu Glu Arg  Asn Phe Val Asp Ser  Arg Gln Leu 
    1055                 1060                 1065             


Lys Val  Cys Ala Thr Cys Phe  Asp Leu Ser Val Ser  Leu Leu Arg 
    1070                 1075                 1080             


Val Leu  Glu Met Thr Ile Thr  Leu Val Pro Glu Ile  Phe Leu Asp 
    1085                 1090                 1095             


Trp Thr  Arg Pro Thr Ser Glu  Met Leu Leu Arg Arg  Leu Ala Gln 
    1100                 1105                 1110             


Leu Leu  Asn Gln Val Leu Asn  Arg Val Thr Ala Glu  Arg Asn Leu 
    1115                 1120                 1125             


Phe Asp  Arg Val Val Thr Leu  Arg Leu Pro Gly Leu  Glu Ser Val 
    1130                 1135                 1140             


Asp His  Tyr Pro Ile Leu Val  Ala Val Thr Gly Ile  Leu Val Gln 
    1145                 1150                 1155             


Leu Leu  Val Arg Gly Pro Ala  Ser Glu Arg Glu Gln  Ala Thr Ser 
    1160                 1165                 1170             


Val Leu  Leu Ala Asp Pro Cys  Phe Gln Leu Arg Ser  Ile Cys Tyr 
    1175                 1180                 1185             


Leu Leu  Gly Gln Pro Glu Pro  Pro Ala Pro Gly Thr  Ala Leu Pro 
    1190                 1195                 1200             


Ala Pro  Asp Arg Lys Arg Phe  Ser Leu Gln Ser Tyr  Ala Asp Tyr 
    1205                 1210                 1215             


Ile Ser  Ala Asp Glu Leu Ala  Gln Val Glu Gln Met  Leu Ala His 
    1220                 1225                 1230             


Leu Thr  Ser Ala Ser Ala Gln  Ala Ala Ala Ala Ser  Leu Pro Thr 
    1235                 1240                 1245             


Ser Glu  Glu Asp Leu Cys Pro  Ile Cys Tyr Ala His  Pro Ile Ser 
    1250                 1255                 1260             


Ala Val  Phe Gln Pro Cys Gly  His Lys Ser Cys Lys  Ala Cys Ile 
    1265                 1270                 1275             


Asn Gln  His Leu Met Asn Asn  Lys Asp Cys Phe Phe  Cys Lys Thr 
    1280                 1285                 1290             


Thr Ile  Val Ser Val Glu Asp  Trp Glu Lys Gly Ala  Asn Thr Ser 
    1295                 1300                 1305             


Thr Thr  Ser Ser Ala Ala 
    1310                 


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus of NF-kappaB1 p105 targeting/ recruiting component


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid repeated n times, wherein n is zero or an 
       integer between 1 to 7

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid repeated n times, wherein n is zero or an 
       integer between 1 to 7

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is any amino acid repeated n times, wherein n is zero or an 
       integer between 1 to 7

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is any amino acid repeated n times, wherein n is zero or an 
       integer between 1 to 7

<400>  7

Xaa Trp Xaa Val Xaa Trp Xaa 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component, (SEQ ID NO. 2 
       with the SG  linker (KVS-4))

<400>  8

Arg Ile Trp Val Trp Leu Leu Ser Gly 
1               5                   


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component, KVS-1 peptide

<400>  9

Arg Ile Phe Val Phe Leu Leu 
1               5           


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component, KVS-5 peptide

<400>  10

Arg Ile Tyr Val Phe Leu Leu 
1               5           


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component, KVS-3

<400>  11

Arg Ile His Val His Leu Leu 
1               5           


<210>  12
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component, KVS-2A

<400>  12

Ala Ile Trp Val Trp Leu Leu 
1               5           


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component, KVS-2B

<400>  13

Lys Ile Trp Val Trp Leu Leu 
1               5           


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component, KVS-2C


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Arg is in the D-form

<400>  14

Arg Ile Trp Val Trp Leu Leu 
1               5           


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component KVS-2D


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Citrulline

<400>  15

Xaa Ile Trp Val Trp Leu Leu 
1               5           


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component KVS-6

<400>  16

Gly Arg Ile Trp Val Trp Leu Leu 
1               5               


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component KVS-7 (INCLUDNG 
       LINKER)

<400>  17

Arg Ile Trp Val Trp Leu Leu Cys Gly 
1               5                   


<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component KVS-8

<400>  18

Arg Ala Trp Val Trp Leu Leu 
1               5           


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component KVS-9

<400>  19

Arg Ile Ala Val Trp Leu Leu 
1               5           


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component KVS-10

<400>  20

Arg Ile Trp Ala Trp Leu Leu 
1               5           


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component KVS-11

<400>  21

Arg Ile Trp Val Ala Leu Leu 
1               5           


<210>  22
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component KVS-12

<400>  22

Arg Ile Trp Val Trp Ala Leu 
1               5           


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component KVS-13

<400>  23

Arg Ile Trp Val Trp Leu Ala 
1               5           


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component KVS-14


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Lys is linked to one Arg on its side chain

<400>  24

Arg Arg Lys Arg Ile Trp Val Trp Leu Leu 
1               5                   10  


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component KVS-15

<400>  25

Arg Lys Arg Ile Trp Val Trp Leu Leu 
1               5                   


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component KVS-16


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Lys is linked to one Arg on its side chain

<400>  26

Arg Lys Arg Ile Trp Val Trp Leu Leu 
1               5                   


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component KVS-18

<400>  27

Arg Arg Arg Ile Trp Val Trp Leu Leu 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component (WT sequence, 
       with linker) KVS-19

<400>  28

Trp Ile Leu Val Arg Leu Trp Ser Gly 
1               5                   


<210>  29
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid repeated n times, wherein n is zero or an 
       integer between 1 to 7

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid repeated m times, wherein m is an integer 
       between 1 to 7

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is any amino acid repeated n times, wherein n is zero or an 
       integer between 1 to 7

<400>  29

Xaa Trp Xaa Trp Xaa 
1               5   


<210>  30
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid repeated n times, wherein n is zero or an 
       integer between 1 to 7

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid repeated m times, wherein m is an integer 
       between 1 to 7

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is any amino acid repeated n times, wherein n is zero or an 
       integer between 1 to 7

<400>  30

Xaa Trp Xaa Tyr Xaa 
1               5   


<210>  31
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid repeated n times, wherein n is zero or an  
       integer between 1 to 7

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid repeated m times, wherein m is  an integer 
       between 1 to 7

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is any amino acid repeated n times, wherein n is zero or an 
       integer between 1 to 7

<400>  31

Xaa Tyr Xaa Trp Xaa 
1               5   


<210>  32
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid repeated n times, wherein n is zero or an 
       integer between 1 to 7

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid repeated m times, wherein m is an integer 
       between 1 to 7

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is any amino acid repeated n times, wherein n is zero or an 
       integer between 1 to 7

<400>  32

Xaa Trp Xaa Phe Xaa 
1               5   


<210>  33
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is any amino acid repeated n times, wherein n is zero or an 
       integer between 1 to 7

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is any amino acid repeated m times, wherein m is an integer 
       between 1 to 7

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is any amino acid repeated n times, wherein n is zero or an 
       integer between 1 to 7

<400>  33

Xaa Phe Xaa Trp Xaa 
1               5   


<210>  34
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid repeated n times, wherein n is zero or an 
       integer between 1 to 7

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid repeated m times, wherein m is an integer 
       between 1 to 7

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is any amino acid repeated n times, wherein n is zero or an 
       integer between 1 to 7

<400>  34

Xaa Tyr Xaa Tyr Xaa 
1               5   


<210>  35
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid repeated n times, wherein n is zero or an 
       integer between 1 to 7

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid repeated m times, wherein m is an integer 
       between 1 to 7

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is any amino acid repeated n times, wherein n is zero or an 
       integer between 1 to 7

<400>  35

Xaa Phe Xaa Tyr Xaa 
1               5   


<210>  36
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid repeated n times, wherein n is zero or an 
       integer between 1 to 7

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid repeated m times, wherein m is an integer 
       between 1 to 7

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is any amino acid repeated n times, wherein n is zero or an 
       integer between 1 to 7

<400>  36

Xaa Tyr Xaa Phe Xaa 
1               5   


<210>  37
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid repeated n times, wherein n is zero or an 
       integer between 1 to 7

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid repeated m times, wherein m is an integer 
       between 1 to 7

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is any amino acid repeated n times, wherein n is zero or an 
       integer between 1 to 7

<400>  37

Xaa Phe Xaa Phe Xaa 
1               5   


<210>  38
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component, PROTAC 2 no 
       linker

<400>  38

Ile Leu Val Arg Leu 
1               5   


<210>  39
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component (for PROTAC 5)

<400>  39

Ile Trp Val Trp Leu Leu Ser Gly 
1               5               


<210>  40
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Kpc1delta1-1039-FLAG

<400>  40

Met Ala Phe Ser Glu Phe Ile Gly Met Ile Gln Glu Ile Gln Gln Ala 
1               5                   10                  15      


Ala Glu Arg Leu Glu Arg Asn Phe Val Asp Ser Arg Gln Leu Lys Val 
            20                  25                  30          


Cys Ala Thr Cys Phe Asp Leu Ser Val Ser Leu Leu Arg Val Leu Glu 
        35                  40                  45              


Met Thr Ile Thr Leu Val Pro Glu Ile Phe Leu Asp Trp Thr Arg Pro 
    50                  55                  60                  


Thr Ser Glu Met Leu Leu Arg Arg Leu Ala Gln Leu Leu Asn Gln Val 
65                  70                  75                  80  


Leu Asn Arg Val Thr Ala Glu Arg Asn Leu Phe Asp Arg Val Val Thr 
                85                  90                  95      


Leu Arg Leu Pro Gly Leu Glu Ser Val Asp His Tyr Pro Ile Leu Val 
            100                 105                 110         


Ala Val Thr Gly Ile Leu Val Gln Leu Leu Val Arg Gly Pro Ala Ser 
        115                 120                 125             


Glu Arg Glu Gln Ala Thr Ser Val Leu Leu Ala Asp Pro Cys Phe Gln 
    130                 135                 140                 


Leu Arg Ser Ile Cys Tyr Leu Leu Gly Gln Pro Glu Pro Pro Ala Pro 
145                 150                 155                 160 


Gly Thr Ala Leu Pro Ala Pro Asp Arg Lys Arg Phe Ser Leu Gln Ser 
                165                 170                 175     


Tyr Ala Asp Tyr Ile Ser Ala Asp Glu Leu Ala Gln Val Glu Gln Met 
            180                 185                 190         


Leu Ala His Leu Thr Ser Ala Ser Ala Gln Ala Ala Ala Ala Ser Leu 
        195                 200                 205             


Pro Thr Ser Glu Glu Asp Leu Cys Pro Ile Cys Tyr Ala His Pro Ile 
    210                 215                 220                 


Ser Ala Val Phe Gln Pro Cys Gly His Lys Ser Cys Lys Ala Cys Ile 
225                 230                 235                 240 


Asn Gln His Leu Met Asn Asn Lys Asp Cys Phe Phe Cys Lys Thr Thr 
                245                 250                 255     


Ile Val Ser Val Glu Asp Trp Glu Lys Gly Ala Asn Thr Ser Thr Thr 
            260                 265                 270         


Ser Ser Ala Ala Met Asp Tyr Lys Asp Asp Asp Asp Lys 
        275                 280                 285 


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component (proviso for 
       Cereblon protac)

<400>  41

Trp Ile Leu Val Arg Leu Trp Gly Gly 
1               5                   


<210>  42
<211>  7
<212>  PRT
<213>  NF-kB1 p105 targeting/ recruiting component

<400>  42

Ile Leu Val Arg Leu Ser Gly 
1               5           


<210>  43
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component

<400>  43

Ile Trp Val Trp Leu Leu Ser 
1               5           


<210>  44
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kB1 p105 targeting/ recruiting component, KVS-1 peptide

<400>  44

Arg Ile Phe Val Phe Leu Leu Ser Gly 
1               5                   


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kB1 p105 targeting/ recruiting component, KVS-5 peptide

<400>  45

Arg Ile Tyr Val Phe Leu Leu Ser Gly 
1               5                   


<210>  46
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component, KVS-3

<400>  46

Arg Ile His Val His Leu Leu Ser Gly 
1               5                   


<210>  47
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component, KVS-2A

<400>  47

Ala Ile Trp Val Trp Leu Leu Ser Gly 
1               5                   


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component, KVS-2B

<400>  48

Lys Ile Trp Val Trp Leu Leu Ser Gly 
1               5                   


<210>  49
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component, KVS-2C


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Arg is in D-form

<400>  49

Arg Ile Trp Val Trp Leu Leu Ser Gly 
1               5                   


<210>  50
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component KVS-2D


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Citruline

<400>  50

Xaa Ile Trp Val Trp Leu Leu Ser Gly 
1               5                   


<210>  51
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component KVS-6

<400>  51

Gly Arg Ile Trp Val Trp Leu Leu Cys Gly 
1               5                   10  


<210>  52
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component KVS-8

<400>  52

Arg Ala Trp Val Trp Leu Leu Ser Gly 
1               5                   


<210>  53
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component KVS-9

<400>  53

Arg Ile Ala Val Trp Leu Leu Ser Gly 
1               5                   


<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component KVS-10

<400>  54

Arg Ile Trp Ala Trp Leu Leu Ser Gly 
1               5                   


<210>  55
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component KVS-11

<400>  55

Arg Ile Trp Val Ala Leu Leu Ser Gly 
1               5                   


<210>  56
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component KVS-12

<400>  56

Arg Ile Trp Val Trp Ala Leu Ser Gly 
1               5                   


<210>  57
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component KVS-13

<400>  57

Arg Ile Trp Val Trp Leu Ala Ser Gly 
1               5                   


<210>  58
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component KVS-14


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Lys is linked to one Arg on its side chain

<400>  58

Arg Arg Lys Arg Ile Trp Val Trp Leu Leu Ser Gly 
1               5                   10          


<210>  59
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component KVS-18

<400>  59

Arg Arg Arg Ile Trp Val Trp Leu Leu Ser Gly 
1               5                   10      


<210>  60
<211>  969
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  UniProtKB - P19838 NFKB1_HUMAN, Nuclear factor NF-kappa-B p105 
       subunit

<400>  60

Met Ala Glu Asp Asp Pro Tyr Leu Gly Arg Pro Glu Gln Met Phe His 
1               5                   10                  15      


Leu Asp Pro Ser Leu Thr His Thr Ile Phe Asn Pro Glu Val Phe Gln 
            20                  25                  30          


Pro Gln Met Ala Leu Pro Thr Ala Asp Gly Pro Tyr Leu Gln Ile Leu 
        35                  40                  45              


Glu Gln Pro Lys Gln Arg Gly Phe Arg Phe Arg Tyr Val Cys Glu Gly 
    50                  55                  60                  


Pro Ser His Gly Gly Leu Pro Gly Ala Ser Ser Glu Lys Asn Lys Lys 
65                  70                  75                  80  


Ser Tyr Pro Gln Val Lys Ile Cys Asn Tyr Val Gly Pro Ala Lys Val 
                85                  90                  95      


Ile Val Gln Leu Val Thr Asn Gly Lys Asn Ile His Leu His Ala His 
            100                 105                 110         


Ser Leu Val Gly Lys His Cys Glu Asp Gly Ile Cys Thr Val Thr Ala 
        115                 120                 125             


Gly Pro Lys Asp Met Val Val Gly Phe Ala Asn Leu Gly Ile Leu His 
    130                 135                 140                 


Val Thr Lys Lys Lys Val Phe Glu Thr Leu Glu Ala Arg Met Thr Glu 
145                 150                 155                 160 


Ala Cys Ile Arg Gly Tyr Asn Pro Gly Leu Leu Val His Pro Asp Leu 
                165                 170                 175     


Ala Tyr Leu Gln Ala Glu Gly Gly Gly Asp Arg Gln Leu Gly Asp Arg 
            180                 185                 190         


Glu Lys Glu Leu Ile Arg Gln Ala Ala Leu Gln Gln Thr Lys Glu Met 
        195                 200                 205             


Asp Leu Ser Val Val Arg Leu Met Phe Thr Ala Phe Leu Pro Asp Ser 
    210                 215                 220                 


Thr Gly Ser Phe Thr Arg Arg Leu Glu Pro Val Val Ser Asp Ala Ile 
225                 230                 235                 240 


Tyr Asp Ser Lys Ala Pro Asn Ala Ser Asn Leu Lys Ile Val Arg Met 
                245                 250                 255     


Asp Arg Thr Ala Gly Cys Val Thr Gly Gly Glu Glu Ile Tyr Leu Leu 
            260                 265                 270         


Cys Asp Lys Val Gln Lys Asp Asp Ile Gln Ile Arg Phe Tyr Glu Glu 
        275                 280                 285             


Glu Glu Asn Gly Gly Val Trp Glu Gly Phe Gly Asp Phe Ser Pro Thr 
    290                 295                 300                 


Asp Val His Arg Gln Phe Ala Ile Val Phe Lys Thr Pro Lys Tyr Lys 
305                 310                 315                 320 


Asp Ile Asn Ile Thr Lys Pro Ala Ser Val Phe Val Gln Leu Arg Arg 
                325                 330                 335     


Lys Ser Asp Leu Glu Thr Ser Glu Pro Lys Pro Phe Leu Tyr Tyr Pro 
            340                 345                 350         


Glu Ile Lys Asp Lys Glu Glu Val Gln Arg Lys Arg Gln Lys Leu Met 
        355                 360                 365             


Pro Asn Phe Ser Asp Ser Phe Gly Gly Gly Ser Gly Ala Gly Ala Gly 
    370                 375                 380                 


Gly Gly Gly Met Phe Gly Ser Gly Gly Gly Gly Gly Gly Thr Gly Ser 
385                 390                 395                 400 


Thr Gly Pro Gly Tyr Ser Phe Pro His Tyr Gly Phe Pro Thr Tyr Gly 
                405                 410                 415     


Gly Ile Thr Phe His Pro Gly Thr Thr Lys Ser Asn Ala Gly Met Lys 
            420                 425                 430         


His Gly Thr Met Asp Thr Glu Ser Lys Lys Asp Pro Glu Gly Cys Asp 
        435                 440                 445             


Lys Ser Asp Asp Lys Asn Thr Val Asn Leu Phe Gly Lys Val Ile Glu 
    450                 455                 460                 


Thr Thr Glu Gln Asp Gln Glu Pro Ser Glu Ala Thr Val Gly Asn Gly 
465                 470                 475                 480 


Glu Val Thr Leu Thr Tyr Ala Thr Gly Thr Lys Glu Glu Ser Ala Gly 
                485                 490                 495     


Val Gln Asp Asn Leu Phe Leu Glu Lys Ala Met Gln Leu Ala Lys Arg 
            500                 505                 510         


His Ala Asn Ala Leu Phe Asp Tyr Ala Val Thr Gly Asp Val Lys Met 
        515                 520                 525             


Leu Leu Ala Val Gln Arg His Leu Thr Ala Val Gln Asp Glu Asn Gly 
    530                 535                 540                 


Asp Ser Val Leu His Leu Ala Ile Ile His Leu His Ser Gln Leu Val 
545                 550                 555                 560 


Arg Asp Leu Leu Glu Val Thr Ser Gly Leu Ile Ser Asp Asp Ile Ile 
                565                 570                 575     


Asn Met Arg Asn Asp Leu Tyr Gln Thr Pro Leu His Leu Ala Val Ile 
            580                 585                 590         


Thr Lys Gln Glu Asp Val Val Glu Asp Leu Leu Arg Ala Gly Ala Asp 
        595                 600                 605             


Leu Ser Leu Leu Asp Arg Leu Gly Asn Ser Val Leu His Leu Ala Ala 
    610                 615                 620                 


Lys Glu Gly His Asp Lys Val Leu Ser Ile Leu Leu Lys His Lys Lys 
625                 630                 635                 640 


Ala Ala Leu Leu Leu Asp His Pro Asn Gly Asp Gly Leu Asn Ala Ile 
                645                 650                 655     


His Leu Ala Met Met Ser Asn Ser Leu Pro Cys Leu Leu Leu Leu Val 
            660                 665                 670         


Ala Ala Gly Ala Asp Val Asn Ala Gln Glu Gln Lys Ser Gly Arg Thr 
        675                 680                 685             


Ala Leu His Leu Ala Val Glu His Asp Asn Ile Ser Leu Ala Gly Cys 
    690                 695                 700                 


Leu Leu Leu Glu Gly Asp Ala His Val Asp Ser Thr Thr Tyr Asp Gly 
705                 710                 715                 720 


Thr Thr Pro Leu His Ile Ala Ala Gly Arg Gly Ser Thr Arg Leu Ala 
                725                 730                 735     


Ala Leu Leu Lys Ala Ala Gly Ala Asp Pro Leu Val Glu Asn Phe Glu 
            740                 745                 750         


Pro Leu Tyr Asp Leu Asp Asp Ser Trp Glu Asn Ala Gly Glu Asp Glu 
        755                 760                 765             


Gly Val Val Pro Gly Thr Thr Pro Leu Asp Met Ala Thr Ser Trp Gln 
    770                 775                 780                 


Val Phe Asp Ile Leu Asn Gly Lys Pro Tyr Glu Pro Glu Phe Thr Ser 
785                 790                 795                 800 


Asp Asp Leu Leu Ala Gln Gly Asp Met Lys Gln Leu Ala Glu Asp Val 
                805                 810                 815     


Lys Leu Gln Leu Tyr Lys Leu Leu Glu Ile Pro Asp Pro Asp Lys Asn 
            820                 825                 830         


Trp Ala Thr Leu Ala Gln Lys Leu Gly Leu Gly Ile Leu Asn Asn Ala 
        835                 840                 845             


Phe Arg Leu Ser Pro Ala Pro Ser Lys Thr Leu Met Asp Asn Tyr Glu 
    850                 855                 860                 


Val Ser Gly Gly Thr Val Arg Glu Leu Val Glu Ala Leu Arg Gln Met 
865                 870                 875                 880 


Gly Tyr Thr Glu Ala Ile Glu Val Ile Gln Ala Ala Ser Ser Pro Val 
                885                 890                 895     


Lys Thr Thr Ser Gln Ala His Ser Leu Pro Leu Ser Pro Ala Ser Thr 
            900                 905                 910         


Arg Gln Gln Ile Asp Glu Leu Arg Asp Ser Asp Ser Val Cys Asp Ser 
        915                 920                 925             


Gly Val Glu Thr Ser Phe Arg Lys Leu Ser Phe Thr Glu Ser Leu Thr 
    930                 935                 940                 


Ser Gly Ala Ser Leu Leu Thr Leu Asn Lys Met Pro His Asp Tyr Gly 
945                 950                 955                 960 


Gln Glu Gly Pro Leu Glu Gly Lys Ile 
                965                 


<210>  61
<211>  435
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  UniProtKB - P19838 NFKB1_HUMAN, Nuclear factor NF-kappa-B p50

<400>  61

Met Ala Glu Asp Asp Pro Tyr Leu Gly Arg Pro Glu Gln Met Phe His 
1               5                   10                  15      


Leu Asp Pro Ser Leu Thr His Thr Ile Phe Asn Pro Glu Val Phe Gln 
            20                  25                  30          


Pro Gln Met Ala Leu Pro Thr Ala Asp Gly Pro Tyr Leu Gln Ile Leu 
        35                  40                  45              


Glu Gln Pro Lys Gln Arg Gly Phe Arg Phe Arg Tyr Val Cys Glu Gly 
    50                  55                  60                  


Pro Ser His Gly Gly Leu Pro Gly Ala Ser Ser Glu Lys Asn Lys Lys 
65                  70                  75                  80  


Ser Tyr Pro Gln Val Lys Ile Cys Asn Tyr Val Gly Pro Ala Lys Val 
                85                  90                  95      


Ile Val Gln Leu Val Thr Asn Gly Lys Asn Ile His Leu His Ala His 
            100                 105                 110         


Ser Leu Val Gly Lys His Cys Glu Asp Gly Ile Cys Thr Val Thr Ala 
        115                 120                 125             


Gly Pro Lys Asp Met Val Val Gly Phe Ala Asn Leu Gly Ile Leu His 
    130                 135                 140                 


Val Thr Lys Lys Lys Val Phe Glu Thr Leu Glu Ala Arg Met Thr Glu 
145                 150                 155                 160 


Ala Cys Ile Arg Gly Tyr Asn Pro Gly Leu Leu Val His Pro Asp Leu 
                165                 170                 175     


Ala Tyr Leu Gln Ala Glu Gly Gly Gly Asp Arg Gln Leu Gly Asp Arg 
            180                 185                 190         


Glu Lys Glu Leu Ile Arg Gln Ala Ala Leu Gln Gln Thr Lys Glu Met 
        195                 200                 205             


Asp Leu Ser Val Val Arg Leu Met Phe Thr Ala Phe Leu Pro Asp Ser 
    210                 215                 220                 


Thr Gly Ser Phe Thr Arg Arg Leu Glu Pro Val Val Ser Asp Ala Ile 
225                 230                 235                 240 


Tyr Asp Ser Lys Ala Pro Asn Ala Ser Asn Leu Lys Ile Val Arg Met 
                245                 250                 255     


Asp Arg Thr Ala Gly Cys Val Thr Gly Gly Glu Glu Ile Tyr Leu Leu 
            260                 265                 270         


Cys Asp Lys Val Gln Lys Asp Asp Ile Gln Ile Arg Phe Tyr Glu Glu 
        275                 280                 285             


Glu Glu Asn Gly Gly Val Trp Glu Gly Phe Gly Asp Phe Ser Pro Thr 
    290                 295                 300                 


Asp Val His Arg Gln Phe Ala Ile Val Phe Lys Thr Pro Lys Tyr Lys 
305                 310                 315                 320 


Asp Ile Asn Ile Thr Lys Pro Ala Ser Val Phe Val Gln Leu Arg Arg 
                325                 330                 335     


Lys Ser Asp Leu Glu Thr Ser Glu Pro Lys Pro Phe Leu Tyr Tyr Pro 
            340                 345                 350         


Glu Ile Lys Asp Lys Glu Glu Val Gln Arg Lys Arg Gln Lys Leu Met 
        355                 360                 365             


Pro Asn Phe Ser Asp Ser Phe Gly Gly Gly Ser Gly Ala Gly Ala Gly 
    370                 375                 380                 


Gly Gly Gly Met Phe Gly Ser Gly Gly Gly Gly Gly Gly Thr Gly Ser 
385                 390                 395                 400 


Thr Gly Pro Gly Tyr Ser Phe Pro His Tyr Gly Phe Pro Thr Tyr Gly 
                405                 410                 415     


Gly Ile Thr Phe His Pro Gly Thr Thr Lys Ser Asn Ala Gly Met Lys 
            420                 425                 430         


His Gly Thr 
        435 


<210>  62
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WILVRLW-Kpc1delta1-1039-FLAG

<400>  62

Met Trp Ile Leu Val Arg Leu Trp Ala Phe Ser Glu Phe Ile Gly Met 
1               5                   10                  15      


Ile Gln Glu Ile Gln Gln Ala Ala Glu Arg Leu Glu Arg Asn Phe Val 
            20                  25                  30          


Asp Ser Arg Gln Leu Lys Val Cys Ala Thr Cys Phe Asp Leu Ser Val 
        35                  40                  45              


Ser Leu Leu Arg Val Leu Glu Met Thr Ile Thr Leu Val Pro Glu Ile 
    50                  55                  60                  


Phe Leu Asp Trp Thr Arg Pro Thr Ser Glu Met Leu Leu Arg Arg Leu 
65                  70                  75                  80  


Ala Gln Leu Leu Asn Gln Val Leu Asn Arg Val Thr Ala Glu Arg Asn 
                85                  90                  95      


Leu Phe Asp Arg Val Val Thr Leu Arg Leu Pro Gly Leu Glu Ser Val 
            100                 105                 110         


Asp His Tyr Pro Ile Leu Val Ala Val Thr Gly Ile Leu Val Gln Leu 
        115                 120                 125             


Leu Val Arg Gly Pro Ala Ser Glu Arg Glu Gln Ala Thr Ser Val Leu 
    130                 135                 140                 


Leu Ala Asp Pro Cys Phe Gln Leu Arg Ser Ile Cys Tyr Leu Leu Gly 
145                 150                 155                 160 


Gln Pro Glu Pro Pro Ala Pro Gly Thr Ala Leu Pro Ala Pro Asp Arg 
                165                 170                 175     


Lys Arg Phe Ser Leu Gln Ser Tyr Ala Asp Tyr Ile Ser Ala Asp Glu 
            180                 185                 190         


Leu Ala Gln Val Glu Gln Met Leu Ala His Leu Thr Ser Ala Ser Ala 
        195                 200                 205             


Gln Ala Ala Ala Ala Ser Leu Pro Thr Ser Glu Glu Asp Leu Cys Pro 
    210                 215                 220                 


Ile Cys Tyr Ala His Pro Ile Ser Ala Val Phe Gln Pro Cys Gly His 
225                 230                 235                 240 


Lys Ser Cys Lys Ala Cys Ile Asn Gln His Leu Met Asn Asn Lys Asp 
                245                 250                 255     


Cys Phe Phe Cys Lys Thr Thr Ile Val Ser Val Glu Asp Trp Glu Lys 
            260                 265                 270         


Gly Ala Asn Thr Ser Thr Thr Ser Ser Ala Ala Met Asp Tyr Lys Asp 
        275                 280                 285             


Asp Asp Asp Lys 
    290         


<210>  63
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WILVRLW-Kpc1delta1-1061-FLAG

<400>  63

Met Trp Ile Leu Val Arg Leu Trp Phe Val Asp Ser Arg Gln Leu Lys 
1               5                   10                  15      


Val Cys Ala Thr Cys Phe Asp Leu Ser Val Ser Leu Leu Arg Val Leu 
            20                  25                  30          


Glu Met Thr Ile Thr Leu Val Pro Glu Ile Phe Leu Asp Trp Thr Arg 
        35                  40                  45              


Pro Thr Ser Glu Met Leu Leu Arg Arg Leu Ala Gln Leu Leu Asn Gln 
    50                  55                  60                  


Val Leu Asn Arg Val Thr Ala Glu Arg Asn Leu Phe Asp Arg Val Val 
65                  70                  75                  80  


Thr Leu Arg Leu Pro Gly Leu Glu Ser Val Asp His Tyr Pro Ile Leu 
                85                  90                  95      


Val Ala Val Thr Gly Ile Leu Val Gln Leu Leu Val Arg Gly Pro Ala 
            100                 105                 110         


Ser Glu Arg Glu Gln Ala Thr Ser Val Leu Leu Ala Asp Pro Cys Phe 
        115                 120                 125             


Gln Leu Arg Ser Ile Cys Tyr Leu Leu Gly Gln Pro Glu Pro Pro Ala 
    130                 135                 140                 


Pro Gly Thr Ala Leu Pro Ala Pro Asp Arg Lys Arg Phe Ser Leu Gln 
145                 150                 155                 160 


Ser Tyr Ala Asp Tyr Ile Ser Ala Asp Glu Leu Ala Gln Val Glu Gln 
                165                 170                 175     


Met Leu Ala His Leu Thr Ser Ala Ser Ala Gln Ala Ala Ala Ala Ser 
            180                 185                 190         


Leu Pro Thr Ser Glu Glu Asp Leu Cys Pro Ile Cys Tyr Ala His Pro 
        195                 200                 205             


Ile Ser Ala Val Phe Gln Pro Cys Gly His Lys Ser Cys Lys Ala Cys 
    210                 215                 220                 


Ile Asn Gln His Leu Met Asn Asn Lys Asp Cys Phe Phe Cys Lys Thr 
225                 230                 235                 240 


Thr Ile Val Ser Val Glu Asp Trp Glu Lys Gly Ala Asn Thr Ser Thr 
                245                 250                 255     


Thr Ser Ser Ala Ala Met Asp Tyr Lys Asp Asp Asp Asp Lys 
            260                 265                 270 


<210>  64
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NF-kappaB1 p105 targeting/ recruiting component

<400>  64

Ile Leu Val Arg Leu Trp 
1               5       


<210>  65
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RIWVWLL-KPC1delta1-1039-FLAG

<400>  65

Met Arg Ile Trp Val Trp Leu Leu Ala Phe Ser Glu Phe Ile Gly Met 
1               5                   10                  15      


Ile Gln Glu Ile Gln Gln Ala Ala Glu Arg Leu Glu Arg Asn Phe Val 
            20                  25                  30          


Asp Ser Arg Gln Leu Lys Val Cys Ala Thr Cys Phe Asp Leu Ser Val 
        35                  40                  45              


Ser Leu Leu Arg Val Leu Glu Met Thr Ile Thr Leu Val Pro Glu Ile 
    50                  55                  60                  


Phe Leu Asp Trp Thr Arg Pro Thr Ser Glu Met Leu Leu Arg Arg Leu 
65                  70                  75                  80  


Ala Gln Leu Leu Asn Gln Val Leu Asn Arg Val Thr Ala Glu Arg Asn 
                85                  90                  95      


Leu Phe Asp Arg Val Val Thr Leu Arg Leu Pro Gly Leu Glu Ser Val 
            100                 105                 110         


Asp His Tyr Pro Ile Leu Val Ala Val Thr Gly Ile Leu Val Gln Leu 
        115                 120                 125             


Leu Val Arg Gly Pro Ala Ser Glu Arg Glu Gln Ala Thr Ser Val Leu 
    130                 135                 140                 


Leu Ala Asp Pro Cys Phe Gln Leu Arg Ser Ile Cys Tyr Leu Leu Gly 
145                 150                 155                 160 


Gln Pro Glu Pro Pro Ala Pro Gly Thr Ala Leu Pro Ala Pro Asp Arg 
                165                 170                 175     


Lys Arg Phe Ser Leu Gln Ser Tyr Ala Asp Tyr Ile Ser Ala Asp Glu 
            180                 185                 190         


Leu Ala Gln Val Glu Gln Met Leu Ala His Leu Thr Ser Ala Ser Ala 
        195                 200                 205             


Gln Ala Ala Ala Ala Ser Leu Pro Thr Ser Glu Glu Asp Leu Cys Pro 
    210                 215                 220                 


Ile Cys Tyr Ala His Pro Ile Ser Ala Val Phe Gln Pro Cys Gly His 
225                 230                 235                 240 


Lys Ser Cys Lys Ala Cys Ile Asn Gln His Leu Met Asn Asn Lys Asp 
                245                 250                 255     


Cys Phe Phe Cys Lys Thr Thr Ile Val Ser Val Glu Asp Trp Glu Lys 
            260                 265                 270         


Gly Ala Asn Thr Ser Thr Thr Ser Ser Ala Ala Met Asp Tyr Lys Asp 
        275                 280                 285             


Asp Asp Asp Lys 
    290         


<210>  66
<211>  1323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KPC1-FLAG

<400>  66

Met Ala Ser Lys Gly Ala Gly Met Ser Phe Ser Arg Lys Ser Tyr Arg 
1               5                   10                  15      


Leu Thr Ser Asp Ala Glu Lys Ser Arg Val Thr Gly Ile Val Gln Glu 
            20                  25                  30          


Lys Leu Leu Asn Asp Tyr Leu Asn Arg Ile Phe Ser Ser Ser Glu His 
        35                  40                  45              


Ala Pro Pro Ala Ala Thr Ser Arg Lys Pro Leu Asn Phe Gln Asn Leu 
    50                  55                  60                  


Pro Glu His Leu Asp Gln Leu Leu Gln Val Asp Asn Glu Glu Glu Glu 
65                  70                  75                  80  


Ser Gln Gly Gln Val Glu Gly Arg Leu Gly Pro Ser Thr Val Val Leu 
                85                  90                  95      


Asp His Thr Gly Gly Phe Glu Gly Leu Leu Leu Val Asp Asp Asp Leu 
            100                 105                 110         


Leu Gly Val Ile Gly His Ser Asn Phe Gly Thr Ile Arg Ser Thr Thr 
        115                 120                 125             


Cys Val Tyr Lys Gly Lys Trp Leu Tyr Glu Val Leu Ile Ser Ser Gln 
    130                 135                 140                 


Gly Leu Met Gln Ile Gly Trp Cys Thr Ile Ser Cys Arg Phe Asn Gln 
145                 150                 155                 160 


Glu Glu Gly Val Gly Asp Thr His Asn Ser Tyr Ala Tyr Asp Gly Asn 
                165                 170                 175     


Arg Val Arg Lys Trp Asn Val Thr Thr Thr Asn Tyr Gly Lys Ala Trp 
            180                 185                 190         


Ala Ala Gly Asp Ile Val Ser Cys Leu Ile Asp Leu Asp Asp Gly Thr 
        195                 200                 205             


Leu Ser Phe Cys Leu Asn Gly Val Ser Leu Gly Thr Ala Phe Glu Asn 
    210                 215                 220                 


Leu Ser Arg Gly Leu Gly Met Ala Tyr Phe Pro Ala Ile Ser Leu Ser 
225                 230                 235                 240 


Phe Lys Glu Ser Val Ala Phe Asn Phe Gly Ser Arg Pro Leu Arg Tyr 
                245                 250                 255     


Pro Val Ala Gly Tyr Arg Pro Leu Gln Asp Pro Pro Ser Ala Asp Leu 
            260                 265                 270         


Val Arg Ala Gln Arg Leu Leu Gly Cys Phe Arg Ala Val Leu Ser Val 
        275                 280                 285             


Glu Leu Asp Pro Val Glu Gly Arg Leu Leu Asp Lys Glu Ser Ser Lys 
    290                 295                 300                 


Trp Arg Leu Arg Gly Gln Pro Thr Val Leu Leu Thr Leu Ala His Ile 
305                 310                 315                 320 


Phe His His Phe Ala Pro Leu Leu Arg Lys Val Tyr Leu Val Glu Ala 
                325                 330                 335     


Val Leu Met Ser Phe Leu Leu Gly Ile Val Glu Lys Gly Thr Pro Thr 
            340                 345                 350         


Gln Ala Gln Ser Val Val His Gln Val Leu Asp Leu Leu Trp Leu Phe 
        355                 360                 365             


Met Glu Asp Tyr Glu Val Gln Asp Cys Leu Lys Gln Leu Met Met Ser 
    370                 375                 380                 


Leu Leu Arg Leu Tyr Arg Phe Ser Pro Ile Val Pro Asp Leu Gly Leu 
385                 390                 395                 400 


Gln Ile His Tyr Leu Arg Leu Thr Ile Ala Ile Leu Arg His Glu Lys 
                405                 410                 415     


Ser Arg Lys Phe Leu Leu Ser Asn Val Leu Phe Asp Val Leu Arg Ser 
            420                 425                 430         


Val Val Phe Phe Tyr Ile Lys Ser Pro Leu Arg Val Glu Glu Ala Gly 
        435                 440                 445             


Leu Gln Glu Leu Ile Pro Thr Thr Trp Trp Pro His Cys Ser Ser Arg 
    450                 455                 460                 


Glu Gly Lys Glu Ser Thr Glu Met Lys Glu Glu Thr Ala Glu Glu Arg 
465                 470                 475                 480 


Leu Arg Arg Arg Ala Tyr Glu Arg Gly Cys Gln Arg Leu Arg Lys Arg 
                485                 490                 495     


Ile Glu Val Val Glu Glu Leu Gln Val Gln Ile Leu Lys Leu Leu Leu 
            500                 505                 510         


Asp Asn Lys Asp Asp Asn Gly Gly Glu Ala Ser Arg Tyr Ile Phe Leu 
        515                 520                 525             


Thr Lys Phe Arg Lys Phe Leu Gln Glu Asn Ala Ser Gly Arg Gly Asn 
    530                 535                 540                 


Met Pro Met Leu Cys Pro Pro Glu Tyr Met Val Cys Phe Leu His Arg 
545                 550                 555                 560 


Leu Ile Ser Ala Leu Arg Tyr Tyr Trp Asp Glu Tyr Lys Ala Ser Asn 
                565                 570                 575     


Pro His Ala Ser Phe Ser Glu Glu Ala Tyr Ile Pro Pro Gln Val Phe 
            580                 585                 590         


Tyr Asn Gly Lys Val Asp Tyr Phe Asp Leu Gln Arg Leu Gly Gly Leu 
        595                 600                 605             


Leu Ser His Leu Arg Lys Thr Leu Lys Asp Asp Leu Ala Ser Lys Ala 
    610                 615                 620                 


Asn Ile Val Ile Asp Pro Leu Glu Leu Gln Ser Thr Ala Met Asp Asp 
625                 630                 635                 640 


Leu Asp Glu Asp Glu Glu Pro Ala Pro Ala Met Ala Gln Arg Pro Met 
                645                 650                 655     


Gln Ala Leu Ala Val Gly Gly Pro Leu Pro Leu Pro Arg Pro Gly Trp 
            660                 665                 670         


Leu Ser Ser Pro Thr Leu Gly Arg Ala Asn Arg Phe Leu Ser Thr Ala 
        675                 680                 685             


Ala Val Ser Leu Met Thr Pro Arg Arg Pro Leu Ser Thr Ser Glu Lys 
    690                 695                 700                 


Val Lys Val Arg Thr Leu Ser Val Glu Gln Arg Thr Arg Glu Asp Ile 
705                 710                 715                 720 


Glu Gly Ser His Trp Asn Glu Gly Leu Leu Leu Gly Arg Pro Pro Glu 
                725                 730                 735     


Glu Pro Glu Gln Pro Leu Thr Glu Asn Ser Leu Leu Glu Val Leu Asp 
            740                 745                 750         


Gly Ala Val Met Met Tyr Asn Leu Ser Val His Gln Gln Leu Gly Lys 
        755                 760                 765             


Met Val Gly Val Ser Asp Asp Val Asn Glu Tyr Ala Met Ala Leu Arg 
    770                 775                 780                 


Asp Thr Glu Asp Lys Leu Arg Arg Cys Pro Lys Arg Arg Lys Asp Ile 
785                 790                 795                 800 


Leu Ala Glu Leu Thr Lys Ser Gln Lys Val Phe Ser Glu Lys Leu Asp 
                805                 810                 815     


His Leu Ser Arg Arg Leu Ala Trp Val His Ala Thr Val Tyr Ser Gln 
            820                 825                 830         


Glu Lys Met Leu Asp Ile Tyr Trp Leu Leu Arg Val Cys Leu Arg Thr 
        835                 840                 845             


Ile Glu His Gly Asp Arg Thr Gly Ser Leu Phe Ala Phe Met Pro Glu 
    850                 855                 860                 


Phe Tyr Leu Ser Val Ala Ile Asn Ser Tyr Ser Ala Leu Lys Asn Tyr 
865                 870                 875                 880 


Phe Gly Pro Val His Ser Met Glu Glu Leu Pro Gly Tyr Glu Glu Thr 
                885                 890                 895     


Leu Thr Arg Leu Ala Ala Ile Leu Ala Lys His Phe Ala Asp Ala Arg 
            900                 905                 910         


Ile Val Gly Thr Asp Ile Arg Asp Ser Leu Met Gln Ala Leu Ala Ser 
        915                 920                 925             


Tyr Val Cys Tyr Pro His Ser Leu Arg Ala Val Glu Arg Ile Pro Glu 
    930                 935                 940                 


Glu Gln Arg Ile Ala Met Val Arg Asn Leu Leu Ala Pro Tyr Glu Gln 
945                 950                 955                 960 


Arg Pro Trp Ala Gln Thr Asn Trp Ile Leu Val Arg Leu Trp Arg Gly 
                965                 970                 975     


Cys Gly Phe Gly Tyr Arg Tyr Thr Arg Leu Pro His Leu Leu Lys Thr 
            980                 985                 990         


Lys Leu Glu Asp Ala Asn Leu Pro  Ser Leu Gln Lys Pro  Cys Pro Ser 
        995                 1000                 1005             


Thr Leu  Leu Gln Gln His Met  Ala Asp Leu Leu Gln  Gln Gly Pro 
    1010                 1015                 1020             


Asp Val  Ala Pro Ser Phe Leu  Asn Ser Val Leu Asn  Gln Leu Asn 
    1025                 1030                 1035             


Trp Ala  Phe Ser Glu Phe Ile  Gly Met Ile Gln Glu  Ile Gln Gln 
    1040                 1045                 1050             


Ala Ala  Glu Arg Leu Glu Arg  Asn Phe Val Asp Ser  Arg Gln Leu 
    1055                 1060                 1065             


Lys Val  Cys Ala Thr Cys Phe  Asp Leu Ser Val Ser  Leu Leu Arg 
    1070                 1075                 1080             


Val Leu  Glu Met Thr Ile Thr  Leu Val Pro Glu Ile  Phe Leu Asp 
    1085                 1090                 1095             


Trp Thr  Arg Pro Thr Ser Glu  Met Leu Leu Arg Arg  Leu Ala Gln 
    1100                 1105                 1110             


Leu Leu  Asn Gln Val Leu Asn  Arg Val Thr Ala Glu  Arg Asn Leu 
    1115                 1120                 1125             


Phe Asp  Arg Val Val Thr Leu  Arg Leu Pro Gly Leu  Glu Ser Val 
    1130                 1135                 1140             


Asp His  Tyr Pro Ile Leu Val  Ala Val Thr Gly Ile  Leu Val Gln 
    1145                 1150                 1155             


Leu Leu  Val Arg Gly Pro Ala  Ser Glu Arg Glu Gln  Ala Thr Ser 
    1160                 1165                 1170             


Val Leu  Leu Ala Asp Pro Cys  Phe Gln Leu Arg Ser  Ile Cys Tyr 
    1175                 1180                 1185             


Leu Leu  Gly Gln Pro Glu Pro  Pro Ala Pro Gly Thr  Ala Leu Pro 
    1190                 1195                 1200             


Ala Pro  Asp Arg Lys Arg Phe  Ser Leu Gln Ser Tyr  Ala Asp Tyr 
    1205                 1210                 1215             


Ile Ser  Ala Asp Glu Leu Ala  Gln Val Glu Gln Met  Leu Ala His 
    1220                 1225                 1230             


Leu Thr  Ser Ala Ser Ala Gln  Ala Ala Ala Ala Ser  Leu Pro Thr 
    1235                 1240                 1245             


Ser Glu  Glu Asp Leu Cys Pro  Ile Cys Tyr Ala His  Pro Ile Ser 
    1250                 1255                 1260             


Ala Val  Phe Gln Pro Cys Gly  His Lys Ser Cys Lys  Ala Cys Ile 
    1265                 1270                 1275             


Asn Gln  His Leu Met Asn Asn  Lys Asp Cys Phe Phe  Cys Lys Thr 
    1280                 1285                 1290             


Thr Ile  Val Ser Val Glu Asp  Trp Glu Lys Gly Ala  Asn Thr Ser 
    1295                 1300                 1305             


Thr Thr  Ser Ser Ala Ala Met  Asp Tyr Lys Asp Asp  Asp Asp Lys 
    1310                 1315                 1320             


<210>  67
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Kpc1delta1-967

<400>  67

Met Trp Ile Leu Val Arg Leu Trp Arg Gly Cys Gly Phe Gly Tyr Arg 
1               5                   10                  15      


Tyr Thr Arg Leu Pro His Leu Leu Lys Thr Lys Leu Glu Asp Ala Asn 
            20                  25                  30          


Leu Pro Ser Leu Gln Lys Pro Cys Pro Ser Thr Leu Leu Gln Gln His 
        35                  40                  45              


Met Ala Asp Leu Leu Gln Gln Gly Pro Asp Val Ala Pro Ser Phe Leu 
    50                  55                  60                  


Asn Ser Val Leu Asn Gln Leu Asn Trp Ala Phe Ser Glu Phe Ile Gly 
65                  70                  75                  80  


Met Ile Gln Glu Ile Gln Gln Ala Ala Glu Arg Leu Glu Arg Asn Phe 
                85                  90                  95      


Val Asp Ser Arg Gln Leu Lys Val Cys Ala Thr Cys Phe Asp Leu Ser 
            100                 105                 110         


Val Ser Leu Leu Arg Val Leu Glu Met Thr Ile Thr Leu Val Pro Glu 
        115                 120                 125             


Ile Phe Leu Asp Trp Thr Arg Pro Thr Ser Glu Met Leu Leu Arg Arg 
    130                 135                 140                 


Leu Ala Gln Leu Leu Asn Gln Val Leu Asn Arg Val Thr Ala Glu Arg 
145                 150                 155                 160 


Asn Leu Phe Asp Arg Val Val Thr Leu Arg Leu Pro Gly Leu Glu Ser 
                165                 170                 175     


Val Asp His Tyr Pro Ile Leu Val Ala Val Thr Gly Ile Leu Val Gln 
            180                 185                 190         


Leu Leu Val Arg Gly Pro Ala Ser Glu Arg Glu Gln Ala Thr Ser Val 
        195                 200                 205             


Leu Leu Ala Asp Pro Cys Phe Gln Leu Arg Ser Ile Cys Tyr Leu Leu 
    210                 215                 220                 


Gly Gln Pro Glu Pro Pro Ala Pro Gly Thr Ala Leu Pro Ala Pro Asp 
225                 230                 235                 240 


Arg Lys Arg Phe Ser Leu Gln Ser Tyr Ala Asp Tyr Ile Ser Ala Asp 
                245                 250                 255     


Glu Leu Ala Gln Val Glu Gln Met Leu Ala His Leu Thr Ser Ala Ser 
            260                 265                 270         


Ala Gln Ala Ala Ala Ala Ser Leu Pro Thr Ser Glu Glu Asp Leu Cys 
        275                 280                 285             


Pro Ile Cys Tyr Ala His Pro Ile Ser Ala Val Phe Gln Pro Cys Gly 
    290                 295                 300                 


His Lys Ser Cys Lys Ala Cys Ile Asn Gln His Leu Met Asn Asn Lys 
305                 310                 315                 320 


Asp Cys Phe Phe Cys Lys Thr Thr Ile Val Ser Val Glu Asp Trp Glu 
                325                 330                 335     


Lys Gly Ala Asn Thr Ser Thr Thr Ser Ser Ala Ala 
            340                 345             


<210>  68
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6HISRGS-Kpc1delta1-967

<400>  68

Met His His His His His His Arg Gly Ser Trp Ile Leu Val Arg Leu 
1               5                   10                  15      


Trp Arg Gly Cys Gly Phe Gly Tyr Arg Tyr Thr Arg Leu Pro His Leu 
            20                  25                  30          


Leu Lys Thr Lys Leu Glu Asp Ala Asn Leu Pro Ser Leu Gln Lys Pro 
        35                  40                  45              


Cys Pro Ser Thr Leu Leu Gln Gln His Met Ala Asp Leu Leu Gln Gln 
    50                  55                  60                  


Gly Pro Asp Val Ala Pro Ser Phe Leu Asn Ser Val Leu Asn Gln Leu 
65                  70                  75                  80  


Asn Trp Ala Phe Ser Glu Phe Ile Gly Met Ile Gln Glu Ile Gln Gln 
                85                  90                  95      


Ala Ala Glu Arg Leu Glu Arg Asn Phe Val Asp Ser Arg Gln Leu Lys 
            100                 105                 110         


Val Cys Ala Thr Cys Phe Asp Leu Ser Val Ser Leu Leu Arg Val Leu 
        115                 120                 125             


Glu Met Thr Ile Thr Leu Val Pro Glu Ile Phe Leu Asp Trp Thr Arg 
    130                 135                 140                 


Pro Thr Ser Glu Met Leu Leu Arg Arg Leu Ala Gln Leu Leu Asn Gln 
145                 150                 155                 160 


Val Leu Asn Arg Val Thr Ala Glu Arg Asn Leu Phe Asp Arg Val Val 
                165                 170                 175     


Thr Leu Arg Leu Pro Gly Leu Glu Ser Val Asp His Tyr Pro Ile Leu 
            180                 185                 190         


Val Ala Val Thr Gly Ile Leu Val Gln Leu Leu Val Arg Gly Pro Ala 
        195                 200                 205             


Ser Glu Arg Glu Gln Ala Thr Ser Val Leu Leu Ala Asp Pro Cys Phe 
    210                 215                 220                 


Gln Leu Arg Ser Ile Cys Tyr Leu Leu Gly Gln Pro Glu Pro Pro Ala 
225                 230                 235                 240 


Pro Gly Thr Ala Leu Pro Ala Pro Asp Arg Lys Arg Phe Ser Leu Gln 
                245                 250                 255     


Ser Tyr Ala Asp Tyr Ile Ser Ala Asp Glu Leu Ala Gln Val Glu Gln 
            260                 265                 270         


Met Leu Ala His Leu Thr Ser Ala Ser Ala Gln Ala Ala Ala Ala Ser 
        275                 280                 285             


Leu Pro Thr Ser Glu Glu Asp Leu Cys Pro Ile Cys Tyr Ala His Pro 
    290                 295                 300                 


Ile Ser Ala Val Phe Gln Pro Cys Gly His Lys Ser Cys Lys Ala Cys 
305                 310                 315                 320 


Ile Asn Gln His Leu Met Asn Asn Lys Asp Cys Phe Phe Cys Lys Thr 
                325                 330                 335     


Thr Ile Val Ser Val Glu Asp Trp Glu Lys Gly Ala Asn Thr Ser Thr 
            340                 345                 350         


Thr Ser Ser Ala Ala 
        355         


