                         SEQUENCE LISTING

<110>  Starget Pharma Ltd.
 
<120>  CONFORMATIONAL CONSTRAINED SOMATOSTATIN RECEPTOR 3 PEPTIDE 
       LIGANDS AND THEIR CONJUGATES AND USES THEREOF

<130>  3296-1-2

<150>  US 63/156374
<151>  2021-03-04

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Phenylalanine

<220>
<221>  DISULFID
<222>  (3)..(9)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  N-Thioethyl glycine

<400>  1

Xaa Arg Cys Phe Xaa Lys Thr Phe Xaa 
1               5                   


<210>  2
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Phenylalanine

<220>
<221>  DISULFID
<222>  (3)..(9)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  N-Thioethyl glycine

<400>  2

Xaa Lys Cys Phe Xaa Lys Thr Phe Xaa 
1               5                   


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  DOTA covalently bound to D-Phenylalanine

<220>
<221>  DISULFID
<222>  (3)..(9)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  N-Thioethyl glycine

<400>  3

Xaa Arg Cys Phe Xaa Lys Thr Phe Xaa 
1               5                   


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  gallium-DOTA covalently bound to D-Phenylalanine

<220>
<221>  DISULFID
<222>  (3)..(9)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  N-Thioethyl glycine

<400>  4

Xaa Arg Cys Phe Xaa Lys Thr Phe Xaa 
1               5                   


<210>  5
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Copper-DOTA covalently bound to D-Phenylalanine

<220>
<221>  DISULFID
<222>  (3)..(9)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  N-Thioethyl glycine

<400>  5

Xaa Arg Cys Phe Xaa Lys Thr Phe Xaa 
1               5                   


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Lutetium-DOTA covalently bound to D-Phenylalanine

<220>
<221>  DISULFID
<222>  (3)..(9)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  N-Thioethyl glycine

<400>  6

Xaa Arg Cys Phe Xaa Lys Thr Phe Xaa 
1               5                   


<210>  7
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  DOTA-GABA covalently  bound to D-Phenylalanine

<220>
<221>  DISULFID
<222>  (3)..(9)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  N-Thioethyl glycine

<400>  7

Xaa Arg Cys Phe Xaa Lys Thr Phe Xaa 
1               5                   


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Gallium-DOTA-GABA covalently bound to D-Phenylalanine

<220>
<221>  DISULFID
<222>  (3)..(9)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  N-Thioethyl glycine

<400>  8

Xaa Arg Cys Phe Xaa Lys Thr Phe Xaa 
1               5                   


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  DOTA covalently bound to D-Phenylalanine

<220>
<221>  DISULFID
<222>  (3)..(9)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  N-Thioethyl glycine

<400>  9

Xaa Lys Cys Phe Xaa Lys Thr Phe Xaa 
1               5                   


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Gallium-DOTA covalently bound to D-Phenylalanine

<220>
<221>  DISULFID
<222>  (3)..(9)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  N-Thioethyl glycine

<400>  10

Xaa Lys Cys Phe Xaa Lys Thr Phe Xaa 
1               5                   


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  DOTA covalently bound to glycine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Phenylalanine

<220>
<221>  DISULFID
<222>  (4)..(10)

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  N-Thioethyl glycine

<400>  11

Gly Xaa Arg Cys Phe Xaa Lys Thr Phe Xaa 
1               5                   10  


<210>  12
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  DOTA covalently bound to alanine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Phenylalanine

<220>
<221>  DISULFID
<222>  (4)..(10)

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  N-Thioethyl glycine

<400>  12

Ala Xaa Arg Cys Phe Xaa Lys Thr Phe Xaa 
1               5                   10  


<210>  13
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  D-Phenylalanine

<220>
<221>  DISULFID
<222>  (6)..(12)

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  N-Thioethyl glycine

<400>  13

Arg Gly Asp Xaa Arg Cys Phe Xaa Lys Thr Phe Xaa 
1               5                   10          


<210>  14
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  DOTA covalently bound to arginine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  D-Phenylalanine

<220>
<221>  DISULFID
<222>  (6)..(12)

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  N-Thioethyl glycine

<400>  14

Arg Gly Asp Xaa Arg Cys Phe Xaa Lys Thr Phe Xaa 
1               5                   10          


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  DOTA-8-aminooctanoic acid covalently  bound to D-Phenylalanine

<220>
<221>  DISULFID
<222>  (3)..(9)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  N-Thioethyl glycine

<400>  15

Xaa Arg Cys Phe Xaa Lys Thr Phe Xaa 
1               5                   


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  DOTA covalently bound to lysine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Phenylalanine

<220>
<221>  DISULFID
<222>  (3)..(9)

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  N-Thioethyl glycine

<400>  16

Lys Xaa Arg Cys Phe Xaa Lys Thr Phe Xaa 
1               5                   10  


<210>  17
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  DOTA covalently  bound to lysine

<220>
<221>  DISULFID
<222>  (1)..(6)

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Phenylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  GABA covalently bound to D-Phenylalanine

<220>
<221>  DISULFID
<222>  (9)..(15)

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  N-Thioethyl glycine

<400>  17

Lys Xaa Arg Gly Asp Glu Xaa Lys Cys Phe Xaa Lys Thr Phe Xaa 
1               5                   10                  15  


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  DOTA covalently bound to 4Amb D-Phenylalanine

<220>
<221>  DISULFID
<222>  (3)..(9)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  N-Thioethyl glycine

<400>  18

Xaa Arg Cys Phe Xaa Lys Thr Phe Xaa 
1               5                   


<210>  19
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  DOTA covalently bound to Phenylalanine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  D-Phenylalanine

<220>
<221>  DISULFID
<222>  (5)..(11)

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  N-Thioethyl glycine

<400>  19

Phe Phe Xaa Arg Cys Phe Xaa Lys Thr Phe Xaa 
1               5                   10      


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  DOTA covalently bound to Phenylalanine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Phenylalanine

<220>
<221>  DISULFID
<222>  (4)..(10)

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  N-Thioethyl glycine

<400>  20

Phe Xaa Arg Cys Phe Xaa Lys Thr Phe Xaa 
1               5                   10  


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  DOTA covalently bound to D-Phenylalanine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ornithine

<220>
<221>  DISULFID
<222>  (3)..(9)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  N-Thioethyl glycine

<400>  21

Xaa Xaa Cys Phe Xaa Lys Thr Phe Xaa 
1               5                   


<210>  22
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  DOTA covalently bound to D-Phenylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Ornithine

<220>
<221>  DISULFID
<222>  (5)..(11)

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  N-Thioethyl glycine

<400>  22

Xaa Glu Glu Xaa Cys Phe Xaa Lys Thr Phe Xaa 
1               5                   10      


<210>  23
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  DOTA covalently bound to D-Phenylalanine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Ornithine

<220>
<221>  DISULFID
<222>  (4)..(10)

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  N-Thioethyl glycine

<400>  23

Xaa Glu Xaa Cys Phe Xaa Lys Thr Phe Xaa 
1               5                   10  


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  DOTA covalently bound to D-Phenylalanine

<220>
<221>  DISULFID
<222>  (3)..(9)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  N-Thioethyl glycine

<400>  24

Xaa Lys Cys Tyr Xaa Lys Thr Phe Xaa 
1               5                   


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  DOTA covalently bound to D-Phenylalanine

<220>
<221>  DISULFID
<222>  (3)..(9)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  N-Thioethyl glycine

<400>  25

Xaa Arg Cys Tyr Xaa Lys Thr Phe Xaa 
1               5                   


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Phenylalanine

<220>
<221>  DISULFID
<222>  (3)..(9)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  N-Thioethyl glycine

<400>  26

Xaa Arg Cys Phe Xaa Lys Thr Tyr Xaa 
1               5                   


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  CPT-8-aminooctanoic acid covalently bound to D-Phenylalanine

<220>
<221>  DISULFID
<222>  (3)..(9)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  N-Thioethyl glycine

<400>  27

Xaa Arg Cys Phe Xaa Lys Thr Phe Xaa 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Niraparib--CO(CH2)3CO covalently bound to D-Phenylalanine

<220>
<221>  DISULFID
<222>  (3)..(9)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Tryptophan

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  N-Thioethyl glycine

<400>  28

Xaa Arg Cys Phe Xaa Lys Thr Phe Xaa 
1               5                   


