                         SEQUENCE LISTING

<110>  THE NATIONAL INSTITUTE FOR BIOTECHNOLOGY IN THE NEGEV LTD.
 
<120>  MODULATORS OF PHOSPHATIDYLSERINE DECARBOXYLASE AND USE THEREOF

<130>  NIBN/013 PCT

<150>  US 61/155,819
<151>  2021-03-03

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  1

Ala Leu Leu Thr Ser Gly Thr Ser Asp Pro Arg Ala Arg Val Thr Tyr 
1               5                   10                  15      


Gly Thr Pro Ser Leu Trp Ala Arg Leu 
            20                  25  


<210>  2
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  2

Met Ser Thr Glu Glu Ala Arg Phe Leu Thr Tyr His Met Trp Pro Leu 
1               5                   10                  15      


Thr Phe Leu Ser Pro Ser Glu Leu Ala 
            20                  25  


<210>  3
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  3

Phe Gln Gln Leu Thr Cys Val Leu Pro Ile Leu Asp Asn Leu Leu Lys 
1               5                   10                  15      


Ala Asn Val Ile Asn Lys Gln Glu His 
            20                  25  


<210>  4
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  4

Ala Leu Ser Thr Ser Ser Pro Ile Pro Ser Val Pro Gln Ser Gln Ala 
1               5                   10                  15      


Gln Pro Gln Thr Gly Ser Gly Ala Ser 
            20                  25  


<210>  5
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  5

Ser Val Pro Gln Ser Gln Ala Gln Pro Gln Thr Gly Ser Gly Ala Ser 
1               5                   10                  15      


Arg Ala Leu Pro Ser Trp Gln Glu Val 
            20                  25  


<210>  6
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  6

Lys Asp Gln Arg Arg Asn Val Gly Asn Met Gln Pro Thr Ala Gln Tyr 
1               5                   10                  15      


Ser Gly Ser Ser Thr Ile Ser Leu 
            20                  


<210>  7
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  7

Pro Asn Gln Ser Ser Arg Ala Phe Gln Gly Thr Asp His Ser Ser Asp 
1               5                   10                  15      


Leu Ala Phe Asp Phe Leu Ser Gln Gln 
            20                  25  


<210>  8
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  8

Glu Met Asn Ser Val Lys Leu Arg Ser Val Lys Arg Ser Glu Gln Asp 
1               5                   10                  15      


Val Lys Pro Lys Pro Val Asp Ala Thr 
            20                  25  


<210>  9
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  9

Asn His Ser Gln Val Val Gln Pro Val Thr Thr Thr Gly Pro Glu His 
1               5                   10                  15      


Ser Lys Pro Leu Glu Lys Ser Asp Gly 
            20                  25  


<210>  10
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  10

Asp Val Asp Lys Leu Arg Glu Gln Leu Ser Thr Ser Glu Asn Ala Leu 
1               5                   10                  15      


Thr Gly Arg Ile Leu Asp Leu Lys Thr 
            20                  25  


<210>  11
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  11

Lys Ala Asp Gly Ile Met Trp Leu Ala Lys Ala Cys Trp Ser Ile Gln 
1               5                   10                  15      


Ser Glu Met Pro Cys Ile Gln Ala Gln 
            20                  25  


<210>  12
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  12

Gly Val Arg Thr Cys Glu Gly Cys Lys Gly Phe Phe Lys Arg Thr Val 
1               5                   10                  15      


Gln Lys Asn Ala Lys Tyr Ile Cys Leu 
            20                  25  


<210>  13
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  13

Glu Met Glu Ala Ser Thr Tyr Asp Gly Phe Ile Trp Lys Ile Ser Asp 
1               5                   10                  15      


Phe Ala Arg Lys Arg Gln Glu 
            20              


<210>  14
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  14

Arg Thr Arg Glu Ala Ser Glu Asn Ser Gly Thr Arg Ser Arg Ala Trp 
1               5                   10                  15      


Leu Ala Val Ala Leu Gly Ala Gly Gly 
            20                  25  


<210>  15
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

Synthetic Peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-amino acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  2,6-dimethyl-L-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Ornithine

<400>  15

Arg Xaa Xaa Phe 
1               


<210>  16
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-amino acid

<400>  16

Arg Arg Arg Lys 
1               


<210>  17
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  D-amino acid

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  2,6-dimethyl-L-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (28)..(29)
<223>  Ornithine

<400>  17

Ala Leu Ser Thr Ser Ser Pro Ile Pro Ser Val Pro Gln Ser Gln Ala 
1               5                   10                  15      


Gln Pro Gln Thr Gly Ser Gly Ala Ser Arg Xaa Xaa Phe 
            20                  25                  


<210>  18
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-amino acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  2,6-dimethyl-L-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Ornithine

<400>  18

Arg Xaa Xaa Phe Ala Leu Ser Thr Ser Ser Pro Ile Pro Ser Val Pro 
1               5                   10                  15      


Gln Ser Gln Ala Gln Pro Gln Thr Gly Ser Gly Ala Ser 
            20                  25                  


<210>  19
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-amino acid

<400>  19

Arg Arg Arg Lys Ala Leu Ser Thr Ser Ser Pro Ile Pro Ser Val Pro 
1               5                   10                  15      


Gln Ser Gln Ala Gln Pro Gln Thr Gly Ser Gly Ala Ser 
            20                  25                  


<210>  20
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  D-amino acid

<400>  20

Ala Leu Ser Thr Ser Ser Pro Ile Pro Ser Val Pro Gln Ser Gln Ala 
1               5                   10                  15      


Gln Pro Gln Thr Gly Ser Gly Ala Ser Arg Arg Arg Lys 
            20                  25                  


<210>  21
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  D-amino acid

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  2,6-dimethyl-L-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Ornithine

<400>  21

Pro Asn Gln Ser Ser Arg Ala Phe Gln Gly Thr Asp His Ser Ser Asp 
1               5                   10                  15      


Leu Ala Phe Asp Phe Leu Ser Gln Gln Arg Xaa Xaa Phe 
            20                  25                  


<210>  22
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-amino acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  2,6-dimethyl-L-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Ornithine

<400>  22

Arg Xaa Xaa Phe Pro Asn Gln Ser Ser Arg Ala Phe Gln Gly Thr Asp 
1               5                   10                  15      


His Ser Ser Asp Leu Ala Phe Asp Phe Leu Ser Gln Gln 
            20                  25                  


<210>  23
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-amino acid

<400>  23

Arg Arg Arg Lys Pro Asn Gln Ser Ser Arg Ala Phe Gln Gly Thr Asp 
1               5                   10                  15      


His Ser Ser Asp Leu Ala Phe Asp Phe Leu Ser Gln Gln 
            20                  25                  


<210>  24
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  D-amino acid

<400>  24

Pro Asn Gln Ser Ser Arg Ala Phe Gln Gly Thr Asp His Ser Ser Asp 
1               5                   10                  15      


Leu Ala Phe Asp Phe Leu Ser Gln Gln Arg Arg Arg Lys 
            20                  25                  


<210>  25
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  D-amino acid

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  2,6-dimethyl-L-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Ornithine

<400>  25

Ala Leu Leu Thr Ser Gly Thr Ser Asp Pro Arg Ala Arg Val Thr Tyr 
1               5                   10                  15      


Gly Thr Pro Ser Leu Trp Ala Arg Leu Arg Xaa Xaa Phe 
            20                  25                  


<210>  26
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-amino acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  2,6-dimethyl-L-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Ornithine

<400>  26

Arg Xaa Xaa Phe Ala Leu Leu Thr Ser Gly Thr Ser Asp Pro Arg Ala 
1               5                   10                  15      


Arg Val Thr Tyr Gly Thr Pro Ser Leu Trp Ala Arg Leu 
            20                  25                  


<210>  27
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-amino acid

<400>  27

Arg Arg Arg Lys Ala Leu Leu Thr Ser Gly Thr Ser Asp Pro Arg Ala 
1               5                   10                  15      


Arg Val Thr Tyr Gly Thr Pro Ser Leu Trp Ala Arg Leu 
            20                  25                  


<210>  28
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  D-amino acid

<400>  28

Ala Leu Leu Thr Ser Gly Thr Ser Asp Pro Arg Ala Arg Val Thr Tyr 
1               5                   10                  15      


Gly Thr Pro Ser Leu Trp Ala Arg Leu Arg Arg Arg Lys 
            20                  25                  


<210>  29
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-amino acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  2,6-dimethyl-L-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Ornithine

<400>  29

Arg Xaa Xaa Phe Phe Gln Gln Leu Thr Cys Val Leu Pro Ile Leu Asp 
1               5                   10                  15      


Asn Leu Leu Lys Ala Asn Val Ile Asn Lys Gln Glu His 
            20                  25                  


<210>  30
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  D-amino acid

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  2,6-dimethyl-L-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Ornithine

<400>  30

Phe Gln Gln Leu Thr Cys Val Leu Pro Ile Leu Asp Asn Leu Leu Lys 
1               5                   10                  15      


Ala Asn Val Ile Asn Lys Gln Glu His Arg Xaa Xaa Phe 
            20                  25                  


<210>  31
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-amino acid

<400>  31

Arg Arg Arg Lys Phe Gln Gln Leu Thr Cys Val Leu Pro Ile Leu Asp 
1               5                   10                  15      


Asn Leu Leu Lys Ala Asn Val Ile Asn Lys Gln Glu His 
            20                  25                  


<210>  32
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Met Cys Gln Ser Glu Ala Arg Gln Gly Pro Glu Leu Arg Ala Ala 
1               5                   10                  15      


Lys Trp Leu His Phe Pro Gln Leu Ala Leu Arg Arg Arg Leu Gly Gln 
            20                  25                  30          


Leu Ser Cys Met Ser Arg Pro Ala Leu Lys Leu Arg Ser Trp Pro Leu 
        35                  40                  45              


Thr Val Leu Tyr Tyr Leu Leu Pro Leu Gly Ala Leu Arg Pro Leu Ser 
    50                  55                  60                  


Arg Val Gly Trp Arg Pro Val Ser Arg Val Ala Leu Tyr Lys Ser Val 
65                  70                  75                  80  


Pro Thr Arg Leu Leu Ser Arg Ala Trp Gly Arg Leu Asn Gln Val Glu 
                85                  90                  95      


Leu Pro His Trp Leu Arg Arg Pro Val Tyr Ser Leu Tyr Ile Trp Thr 
            100                 105                 110         


Phe Gly Val Asn Met Lys Glu Ala Ala Val Glu Asp Leu His His Tyr 
        115                 120                 125             


Arg Asn Leu Ser Glu Phe Phe Arg Arg Lys Leu Lys Pro Gln Ala Arg 
    130                 135                 140                 


Pro Val Cys Gly Leu His Ser Val Ile Ser Pro Ser Asp Gly Arg Ile 
145                 150                 155                 160 


Leu Asn Phe Gly Gln Val Lys Asn Cys Glu Val Glu Gln Val Lys Gly 
                165                 170                 175     


Val Thr Tyr Ser Leu Glu Ser Phe Leu Gly Pro Arg Thr Cys Thr Glu 
            180                 185                 190         


Asp Leu Pro Phe Pro Pro Ala Ala Ser Cys Asp Ser Phe Lys Asn Gln 
        195                 200                 205             


Leu Val Thr Arg Glu Gly Asn Glu Leu Tyr His Cys Val Ile Tyr Leu 
    210                 215                 220                 


Ala Pro Gly Asp Tyr His Cys Phe His Ser Pro Thr Asp Trp Thr Val 
225                 230                 235                 240 


Ser His Arg Arg His Phe Pro Gly Ser Leu Met Ser Val Asn Pro Gly 
                245                 250                 255     


Met Ala Arg Trp Ile Lys Glu Leu Phe Cys His Asn Glu Arg Val Val 
            260                 265                 270         


Leu Thr Gly Asp Trp Lys His Gly Phe Phe Ser Leu Thr Ala Val Gly 
        275                 280                 285             


Ala Thr Asn Val Gly Ser Ile Arg Ile Tyr Phe Asp Arg Asp Leu His 
    290                 295                 300                 


Thr Asn Ser Pro Arg His Ser Lys Gly Ser Tyr Asn Asp Phe Ser Val 
305                 310                 315                 320 


Val Gly Ser Leu Thr Arg 
                325     


<210>  33
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  33
aagcgguguu ucucagaatt gtt                                               23


<210>  34
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  34
aacaauucug agaaacccgc tt                                                22


<210>  35
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(25)
<223>  D-amino acid

<400>  35

Ala Leu Leu Thr Ser Gly Thr Ser Asp Pro Arg Ala Arg Val Thr Tyr 
1               5                   10                  15      


Gly Thr Pro Ser Leu Trp Ala Arg Leu 
            20                  25  


<210>  36
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  36

His Ala Ile Tyr Pro Arg His 
1               5           


<210>  37
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  37

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  38
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(26)
<223>  D-amino acid

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  2,6-dimethyl-L-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Ornithine

<400>  38

Ala Leu Leu Thr Ser Gly Thr Ser Asp Pro Arg Ala Arg Val Thr Tyr 
1               5                   10                  15      


Gly Thr Pro Ser Leu Trp Ala Arg Leu Arg Xaa Xaa Phe 
            20                  25                  


