                         SEQUENCE LISTING

<110>  Synklino ApS
 
<120>  Compositions for ex vivo organ care

<130>  P5923PC00

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  1

Gln His His Gly Val Thr Lys Cys Asn Ile Thr Cys Ser Lys Met Thr 
1               5                   10                  15      


Ser Lys Ile Pro Val Ala Leu Leu Ile His Tyr Gln Gln Asn Gln Ala 
            20                  25                  30          


Ser Cys Gly Lys Arg Ala Ile Ile Leu Glu Thr Arg Gln His Arg Leu 
        35                  40                  45              


Phe Cys Ala Asp Pro Lys Glu Gln Trp Val Lys Asp Ala Met Gln His 
    50                  55                  60                  


Leu Asp Arg Gln Ala Ala Ala Leu Thr Arg Asn Gly 
65                  70                  75      


<210>  2
<211>  340
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  2

Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro 
1               5                   10                  15      


Leu Glu Thr Phe Thr Arg His Arg Gln Arg Arg Gly Trp Glu Gln Leu 
            20                  25                  30          


Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala 
        35                  40                  45              


Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu 
    50                  55                  60                  


Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln 
65                  70                  75                  80  


Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu 
                85                  90                  95      


Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Ser 
            100                 105                 110         


Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr 
        115                 120                 125             


Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Ile Ser Phe Ser Thr Arg 
    130                 135                 140                 


Gly Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln 
145                 150                 155                 160 


Leu Glu Glu Arg Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu 
                165                 170                 175     


Glu Ala Ala Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln 
            180                 185                 190         


Asp Leu Asp Ala Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala 
        195                 200                 205             


Leu Ala Tyr Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg 
    210                 215                 220                 


Ile Arg Asn Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu 
225                 230                 235                 240 


Pro Gly Phe Tyr Arg Thr Gly Leu Thr Leu Ala Ala Pro Glu Ala Ala 
                245                 250                 255     


Gly Glu Val Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp 
            260                 265                 270         


Ala Ile Thr Gly Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu 
        275                 280                 285             


Gly Trp Pro Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro 
    290                 295                 300                 


Thr Asp Pro Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro 
305                 310                 315                 320 


Asp Lys Glu Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro 
                325                 330                 335     


Gly Lys Pro Pro 
            340 


<210>  3
<211>  112
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  3

Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro 
1               5                   10                  15      


Leu Glu Thr Phe Thr Arg His Arg Gln Arg Arg Gly Trp Glu Gln Leu 
            20                  25                  30          


Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala 
        35                  40                  45              


Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu 
    50                  55                  60                  


Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln 
65                  70                  75                  80  


Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu 
                85                  90                  95      


Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Ser 
            100                 105                 110         


<210>  4
<211>  15
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  4

Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro 
1               5                   10                  15  


<210>  5
<211>  213
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  5

Thr Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Ile Ser Phe Ser Thr 
1               5                   10                  15      


Arg Gly Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg 
            20                  25                  30          


Gln Leu Glu Glu Arg Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe 
        35                  40                  45              


Leu Glu Ala Ala Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser 
    50                  55                  60                  


Gln Asp Leu Asp Ala Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro 
65                  70                  75                  80  


Ala Leu Ala Tyr Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly 
                85                  90                  95      


Arg Ile Arg Asn Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser 
            100                 105                 110         


Leu Pro Gly Phe Tyr Arg Thr Gly Leu Thr Leu Ala Ala Pro Glu Ala 
        115                 120                 125             


Ala Gly Glu Val Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu 
    130                 135                 140                 


Asp Ala Ile Thr Gly Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile 
145                 150                 155                 160 


Leu Gly Trp Pro Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile 
                165                 170                 175     


Pro Thr Asp Pro Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile 
            180                 185                 190         


Pro Asp Lys Glu Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln 
        195                 200                 205             


Pro Gly Lys Pro Pro 
    210             


<210>  6
<211>  421
<212>  PRT
<213>  artificial sequence

<220>
<223>  fusion protein SYN002

<400>  6

Met Gln His His Gly Val Thr Lys Cys Asn Ile Thr Cys Ser Lys Met 
1               5                   10                  15      


Thr Ser Lys Ile Pro Val Ala Leu Leu Ile His Tyr Gln Gln Asn Gln 
            20                  25                  30          


Ala Ser Cys Gly Lys Arg Ala Ile Ile Leu Glu Thr Arg Gln His Arg 
        35                  40                  45              


Leu Ala Cys Ala Asp Pro Lys Glu Gln Trp Val Lys Asp Ala Met Gln 
    50                  55                  60                  


His Leu Asp Arg Gln Ala Ala Ala Leu Thr Arg Asn Gly Gly Gly Ser 
65                  70                  75                  80  


Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro Leu Glu Thr 
                85                  90                  95      


Phe Thr Arg His Arg Gln Arg Arg Gly Trp Glu Gln Leu Glu Gln Cys 
            100                 105                 110         


Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu 
        115                 120                 125             


Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu Ala Ser Pro 
    130                 135                 140                 


Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln 
145                 150                 155                 160 


Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe Val 
                165                 170                 175     


Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Ser Gly Pro Ala 
            180                 185                 190         


Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu 
        195                 200                 205             


Phe Leu Gly Asp Gly Gly Asp Ile Ser Phe Ser Thr Arg Gly Thr Gln 
    210                 215                 220                 


Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu 
225                 230                 235                 240 


Arg Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala 
                245                 250                 255     


Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp 
            260                 265                 270         


Ala Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr 
        275                 280                 285             


Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg Ile Arg Asn 
    290                 295                 300                 


Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe 
305                 310                 315                 320 


Tyr Arg Thr Gly Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val 
                325                 330                 335     


Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr 
            340                 345                 350         


Gly Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro 
        355                 360                 365             


Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro 
    370                 375                 380                 


Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Lys Glu 
385                 390                 395                 400 


Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro 
                405                 410                 415     


Pro Lys Asp Glu Leu 
            420     


<210>  7
<211>  397
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Pro Ile Ser Leu Ser Trp Leu Leu Arg Leu Ala Thr Phe Cys 
1               5                   10                  15      


His Leu Thr Val Leu Leu Ala Gly Gln His His Gly Val Thr Lys Cys 
            20                  25                  30          


Asn Ile Thr Cys Ser Lys Met Thr Ser Lys Ile Pro Val Ala Leu Leu 
        35                  40                  45              


Ile His Tyr Gln Gln Asn Gln Ala Ser Cys Gly Lys Arg Ala Ile Ile 
    50                  55                  60                  


Leu Glu Thr Arg Gln His Arg Leu Phe Cys Ala Asp Pro Lys Glu Gln 
65                  70                  75                  80  


Trp Val Lys Asp Ala Met Gln His Leu Asp Arg Gln Ala Ala Ala Leu 
                85                  90                  95      


Thr Arg Asn Gly Gly Thr Phe Glu Lys Gln Ile Gly Glu Val Lys Pro 
            100                 105                 110         


Arg Thr Thr Pro Ala Ala Gly Gly Met Asp Glu Ser Val Val Leu Glu 
        115                 120                 125             


Pro Glu Ala Thr Gly Glu Ser Ser Ser Leu Glu Pro Thr Pro Ser Ser 
    130                 135                 140                 


Gln Glu Ala Gln Arg Ala Leu Gly Thr Ser Pro Glu Leu Pro Thr Gly 
145                 150                 155                 160 


Val Thr Gly Ser Ser Gly Thr Arg Leu Pro Pro Thr Pro Lys Ala Gln 
                165                 170                 175     


Asp Gly Gly Pro Val Gly Thr Glu Leu Phe Arg Val Pro Pro Val Ser 
            180                 185                 190         


Thr Ala Ala Thr Trp Gln Ser Ser Ala Pro His Gln Pro Gly Pro Ser 
        195                 200                 205             


Leu Trp Ala Glu Ala Lys Thr Ser Glu Ala Pro Ser Thr Gln Asp Pro 
    210                 215                 220                 


Ser Thr Gln Ala Ser Thr Ala Ser Ser Pro Ala Pro Glu Glu Asn Ala 
225                 230                 235                 240 


Pro Ser Glu Gly Gln Arg Val Trp Gly Gln Gly Gln Ser Pro Arg Pro 
                245                 250                 255     


Glu Asn Ser Leu Glu Arg Glu Glu Met Gly Pro Val Pro Ala His Thr 
            260                 265                 270         


Asp Ala Phe Gln Asp Trp Gly Pro Gly Ser Met Ala His Val Ser Val 
        275                 280                 285             


Val Pro Val Ser Ser Glu Gly Thr Pro Ser Arg Glu Pro Val Ala Ser 
    290                 295                 300                 


Gly Ser Trp Thr Pro Lys Ala Glu Glu Pro Ile His Ala Thr Met Asp 
305                 310                 315                 320 


Pro Gln Arg Leu Gly Val Leu Ile Thr Pro Val Pro Asp Ala Gln Ala 
                325                 330                 335     


Ala Thr Arg Arg Gln Ala Val Gly Leu Leu Ala Phe Leu Gly Leu Leu 
            340                 345                 350         


Phe Cys Leu Gly Val Ala Met Phe Thr Tyr Gln Ser Leu Gln Gly Cys 
        355                 360                 365             


Pro Arg Lys Met Ala Gly Glu Met Ala Glu Gly Leu Arg Tyr Ile Pro 
    370                 375                 380                 


Arg Ser Cys Gly Ser Asn Ser Tyr Val Leu Val Pro Val 
385                 390                 395         


<210>  8
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  8

Lys Asp Glu Leu 
1               


<210>  9
<211>  638
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  9

Met His Leu Thr Pro His Trp Ile Pro Leu Val Ala Ser Leu Gly Leu 
1               5                   10                  15      


Leu Ala Gly Gly Ser Phe Ala Ser Ala Ala Glu Glu Ala Phe Asp Leu 
            20                  25                  30          


Trp Asn Glu Cys Ala Lys Ala Cys Val Leu Asp Leu Lys Asp Gly Val 
        35                  40                  45              


Arg Ser Ser Arg Met Ser Val Asp Pro Ala Ile Ala Asp Thr Asn Gly 
    50                  55                  60                  


Gln Gly Val Leu His Tyr Ser Met Val Leu Glu Gly Gly Asn Asp Ala 
65                  70                  75                  80  


Leu Lys Leu Ala Ile Asp Asn Ala Leu Ser Ile Thr Ser Asp Gly Leu 
                85                  90                  95      


Thr Ile Arg Leu Glu Gly Gly Val Glu Pro Asn Lys Pro Val Arg Tyr 
            100                 105                 110         


Ser Tyr Thr Arg Gln Ala Arg Gly Ser Trp Ser Leu Asn Trp Leu Val 
        115                 120                 125             


Pro Ile Gly His Glu Lys Pro Ser Asn Ile Lys Val Phe Ile His Glu 
    130                 135                 140                 


Leu Asn Ala Gly Asn Gln Leu Ser His Met Ser Pro Ile Tyr Thr Ile 
145                 150                 155                 160 


Glu Met Gly Asp Glu Leu Leu Ala Lys Leu Ala Arg Asp Ala Thr Phe 
                165                 170                 175     


Phe Val Arg Ala His Glu Ser Asn Glu Met Gln Pro Thr Leu Ala Ile 
            180                 185                 190         


Ser His Ala Gly Val Ser Val Val Met Ala Gln Ala Gln Pro Arg Arg 
        195                 200                 205             


Glu Lys Arg Trp Ser Glu Trp Ala Ser Gly Lys Val Leu Cys Leu Leu 
    210                 215                 220                 


Asp Pro Leu Asp Gly Val Tyr Asn Tyr Leu Ala Gln Gln Arg Cys Asn 
225                 230                 235                 240 


Leu Asp Asp Thr Trp Glu Gly Lys Ile Tyr Arg Val Leu Ala Gly Asn 
                245                 250                 255     


Pro Ala Lys His Asp Leu Asp Ile Lys Pro Thr Val Ile Ser His Arg 
            260                 265                 270         


Leu His Phe Pro Glu Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln 
        275                 280                 285             


Ala Cys His Leu Pro Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg 
    290                 295                 300                 


Gly Trp Glu Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val 
305                 310                 315                 320 


Ala Leu Tyr Leu Ala Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val 
                325                 330                 335     


Ile Arg Asn Ala Leu Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu 
            340                 345                 350         


Ala Ile Arg Glu Gln Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala 
        355                 360                 365             


Ala Ala Glu Ser Glu Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu 
    370                 375                 380                 


Ala Gly Ala Ala Ser Ala Asp Val Val Ser Leu Thr Cys Pro Val Ala 
385                 390                 395                 400 


Ala Gly Glu Cys Ala Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu 
                405                 410                 415     


Arg Asn Tyr Pro Thr Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Ile 
            420                 425                 430         


Ser Phe Ser Thr Arg Gly Thr Gln Asn Trp Thr Val Glu Arg Leu Leu 
        435                 440                 445             


Gln Ala His Arg Gln Leu Glu Glu Arg Gly Tyr Val Phe Val Gly Tyr 
    450                 455                 460                 


His Gly Thr Phe Leu Glu Ala Ala Gln Ser Ile Val Phe Gly Gly Val 
465                 470                 475                 480 


Arg Ala Arg Ser Gln Asp Leu Asp Ala Ile Trp Arg Gly Phe Tyr Ile 
                485                 490                 495     


Ala Gly Asp Pro Ala Leu Ala Tyr Gly Tyr Ala Gln Asp Gln Glu Pro 
            500                 505                 510         


Asp Ala Arg Gly Arg Ile Arg Asn Gly Ala Leu Leu Arg Val Tyr Val 
        515                 520                 525             


Pro Arg Ser Ser Leu Pro Gly Phe Tyr Arg Thr Gly Leu Thr Leu Ala 
    530                 535                 540                 


Ala Pro Glu Ala Ala Gly Glu Val Glu Arg Leu Ile Gly His Pro Leu 
545                 550                 555                 560 


Pro Leu Arg Leu Asp Ala Ile Thr Gly Pro Glu Glu Glu Gly Gly Arg 
                565                 570                 575     


Leu Glu Thr Ile Leu Gly Trp Pro Leu Ala Glu Arg Thr Val Val Ile 
            580                 585                 590         


Pro Ser Ala Ile Pro Thr Asp Pro Arg Asn Val Gly Gly Asp Leu Asp 
        595                 600                 605             


Pro Ser Ser Ile Pro Asp Lys Glu Gln Ala Ile Ser Ala Leu Pro Asp 
    610                 615                 620                 


Tyr Ala Ser Gln Pro Gly Lys Pro Pro Arg Glu Asp Leu Lys 
625                 630                 635             


<210>  10
<211>  354
<212>  PRT
<213>  cytomegalovirus

<400>  10

Met Thr Pro Thr Thr Thr Thr Ala Glu Leu Thr Thr Glu Phe Asp Tyr 
1               5                   10                  15      


Asp Glu Ala Ala Thr Pro Cys Val Phe Thr Asp Val Leu Asn Gln Ser 
            20                  25                  30          


Lys Pro Val Thr Leu Phe Leu Tyr Gly Val Val Phe Leu Phe Gly Ser 
        35                  40                  45              


Ile Gly Asn Phe Leu Val Ile Phe Thr Ile Thr Trp Arg Arg Arg Ile 
    50                  55                  60                  


Gln Cys Ser Gly Asp Val Tyr Phe Ile Asn Leu Ala Ala Ala Asp Leu 
65                  70                  75                  80  


Leu Phe Val Cys Thr Leu Pro Leu Trp Met Gln Tyr Leu Leu Asp His 
                85                  90                  95      


Asn Ser Leu Ala Ser Val Pro Cys Thr Leu Leu Thr Ala Cys Phe Tyr 
            100                 105                 110         


Val Ala Met Phe Ala Ser Leu Cys Phe Ile Thr Glu Ile Ala Leu Asp 
        115                 120                 125             


Arg Tyr Tyr Ala Ile Val Tyr Met Arg Tyr Arg Pro Val Lys Gln Ala 
    130                 135                 140                 


Cys Leu Phe Ser Ile Phe Trp Trp Ile Phe Ala Val Ile Ile Ala Ile 
145                 150                 155                 160 


Pro His Phe Met Val Val Thr Lys Lys Asp Asn Gln Cys Met Thr Asp 
                165                 170                 175     


Tyr Asp Tyr Leu Glu Val Ser Tyr Pro Ile Ile Leu Asn Val Glu Leu 
            180                 185                 190         


Met Leu Gly Ala Phe Val Ile Pro Leu Ser Val Ile Ser Tyr Cys Tyr 
        195                 200                 205             


Tyr Arg Ile Ser Arg Ile Val Ala Val Ser Gln Ser Arg His Lys Gly 
    210                 215                 220                 


Arg Ile Val Arg Val Leu Ile Ala Val Val Leu Val Phe Ile Ile Phe 
225                 230                 235                 240 


Trp Leu Pro Tyr His Leu Thr Leu Phe Val Asp Thr Leu Lys Leu Leu 
                245                 250                 255     


Lys Trp Ile Ser Ser Ser Cys Glu Phe Glu Arg Ser Leu Lys Arg Ala 
            260                 265                 270         


Leu Ile Leu Thr Glu Ser Leu Ala Phe Cys His Cys Cys Leu Asn Pro 
        275                 280                 285             


Leu Leu Tyr Val Phe Val Gly Thr Lys Phe Arg Gln Glu Leu His Cys 
    290                 295                 300                 


Leu Leu Ala Glu Phe Arg Gln Arg Leu Phe Ser Arg Asp Val Ser Trp 
305                 310                 315                 320 


Tyr His Ser Met Ser Phe Ser Arg Arg Ser Ser Pro Ser Arg Arg Glu 
                325                 330                 335     


Thr Ser Ser Asp Thr Leu Ser Asp Glu Val Cys Arg Val Ser Gln Ile 
            340                 345                 350         


Ile Pro 
        


<210>  11
<211>  397
<212>  PRT
<213>  artificial sequence

<220>
<223>  fusion protein SYN000

<400>  11

Met Gln His His Gly Val Thr Lys Cys Asn Ile Thr Cys Ser Lys Met 
1               5                   10                  15      


Thr Ser Lys Ile Pro Val Ala Leu Leu Ile His Tyr Gln Gln Asn Gln 
            20                  25                  30          


Ala Ser Cys Gly Lys Arg Ala Ile Ile Leu Glu Thr Arg Gln His Arg 
        35                  40                  45              


Leu Phe Cys Ala Asp Pro Lys Glu Gln Trp Val Lys Asp Ala Met Gln 
    50                  55                  60                  


His Leu Asp Arg Gln Ala Ala Ala Leu Thr Arg Asn Arg Gln Pro Arg 
65                  70                  75                  80  


Gly Trp Glu Gln Leu Glu Gln Ser Gly Tyr Pro Val Gln Arg Leu Val 
                85                  90                  95      


Ala Leu Tyr Leu Ala Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val 
            100                 105                 110         


Ile Arg Asn Ala Leu Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu 
        115                 120                 125             


Ala Ile Arg Glu Gln Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala 
    130                 135                 140                 


Ala Ala Glu Ser Glu Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu 
145                 150                 155                 160 


Ala Gly Ala Ala Ser Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu 
                165                 170                 175     


Arg Asn Tyr Pro Thr Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Ile 
            180                 185                 190         


Ser Phe Ser Thr Arg Gly Thr Gln Asn Trp Thr Val Glu Arg Leu Leu 
        195                 200                 205             


Gln Ala His Arg Gln Leu Glu Glu Arg Gly Tyr Val Phe Val Gly Tyr 
    210                 215                 220                 


His Gly Thr Phe Leu Glu Ala Ala Gln Ser Ile Val Phe Gly Gly Val 
225                 230                 235                 240 


Arg Ala Arg Ser Gln Asp Leu Asp Ala Ile Trp Arg Gly Phe Tyr Ile 
                245                 250                 255     


Ala Gly Asp Pro Ala Leu Ala Tyr Gly Tyr Ala Gln Asp Gln Glu Pro 
            260                 265                 270         


Asp Ala Arg Gly Arg Ile Arg Asn Gly Ala Leu Leu Arg Val Tyr Val 
        275                 280                 285             


Pro Arg Ser Ser Leu Pro Gly Phe Tyr Arg Thr Gly Leu Thr Leu Ala 
    290                 295                 300                 


Ala Pro Glu Ala Ala Gly Glu Val Glu Arg Leu Ile Gly His Pro Leu 
305                 310                 315                 320 


Pro Leu Arg Leu Asp Ala Ile Thr Gly Pro Glu Glu Glu Gly Gly Arg 
                325                 330                 335     


Leu Glu Thr Ile Leu Gly Trp Pro Leu Ala Glu Arg Thr Val Val Ile 
            340                 345                 350         


Pro Ser Ala Ile Pro Thr Asp Pro Arg Asn Val Gly Gly Asp Leu Asp 
        355                 360                 365             


Pro Ser Ser Ile Pro Asp Lys Glu Gln Ala Ile Ser Ala Leu Pro Asp 
    370                 375                 380                 


Tyr Ala Ser Gln Pro Gly Lys Pro Pro Lys Asp Glu Leu 
385                 390                 395         


<210>  12
<211>  396
<212>  PRT
<213>  artificial sequence

<220>
<223>  fusion protein SYN001

<400>  12

Met Gln His His Gly Val Thr Lys Cys Asn Ile Thr Cys Ser Lys Met 
1               5                   10                  15      


Thr Ser Lys Ile Pro Val Ala Leu Leu Ile His Tyr Gln Gln Asn Gln 
            20                  25                  30          


Ala Ser Cys Gly Lys Arg Ala Ile Ile Leu Glu Thr Arg Gln His Arg 
        35                  40                  45              


Leu Ala Cys Ala Asp Pro Lys Glu Gln Trp Val Lys Asp Ala Met Gln 
    50                  55                  60                  


His Leu Asp Arg Gln Ala Ala Ala Leu Thr Arg Asn Arg Gln Pro Arg 
65                  70                  75                  80  


Gly Trp Glu Gln Leu Glu Gln Ser Gly Tyr Pro Val Gln Arg Leu Val 
                85                  90                  95      


Ala Leu Tyr Leu Ala Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val 
            100                 105                 110         


Ile Arg Asn Ala Leu Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu 
        115                 120                 125             


Ala Ile Arg Glu Gln Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala 
    130                 135                 140                 


Ala Ala Glu Ser Glu Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu 
145                 150                 155                 160 


Ala Gly Ala Ala Ser Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu 
                165                 170                 175     


Arg Asn Tyr Pro Thr Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Ile 
            180                 185                 190         


Ser Phe Ser Thr Arg Gly Thr Gln Asn Trp Thr Val Glu Arg Leu Leu 
        195                 200                 205             


Gln Ala His Arg Gln Leu Glu Glu Arg Gly Tyr Val Phe Val Gly Tyr 
    210                 215                 220                 


His Gly Thr Phe Leu Glu Ala Ala Gln Ser Ile Val Phe Gly Gly Val 
225                 230                 235                 240 


Arg Ala Arg Ser Gln Asp Leu Asp Ala Ile Trp Arg Gly Phe Tyr Ile 
                245                 250                 255     


Ala Gly Asp Pro Ala Leu Ala Tyr Gly Tyr Ala Gln Asp Gln Glu Pro 
            260                 265                 270         


Asp Ala Arg Gly Arg Ile Arg Asn Gly Ala Leu Leu Arg Val Tyr Val 
        275                 280                 285             


Pro Arg Ser Ser Leu Pro Gly Phe Tyr Arg Thr Gly Leu Thr Leu Ala 
    290                 295                 300                 


Ala Pro Glu Ala Ala Gly Glu Val Glu Arg Leu Ile Gly His Pro Leu 
305                 310                 315                 320 


Pro Leu Arg Leu Asp Ala Ile Thr Gly Pro Glu Glu Glu Gly Gly Arg 
                325                 330                 335     


Leu Glu Thr Ile Leu Gly Trp Pro Leu Ala Glu Arg Thr Val Val Ile 
            340                 345                 350         


Pro Ser Ala Ile Pro Thr Asp Pro Arg Asn Val Gly Gly Asp Leu Asp 
        355                 360                 365             


Pro Ser Ser Ile Pro Asp Lys Glu Gln Ala Ile Ser Ala Leu Pro Asp 
    370                 375                 380                 


Tyr Ala Ser Gln Pro Gly Lys Pro Pro Lys Asp Glu 
385                 390                 395     


<210>  13
<211>  421
<212>  PRT
<213>  artificial sequence

<220>
<223>  fusion protein SYN014

<400>  13

Met Gln His His Gly Val Thr Lys Cys Asn Ile Thr Cys Ser Lys Met 
1               5                   10                  15      


Thr Ser Lys Ile Pro Val Ala Leu Leu Ile His Tyr Gln Gln Asn Gln 
            20                  25                  30          


Ala Ser Cys Gly Lys Arg Ala Ile Ile Leu Glu Thr Arg Gln His Arg 
        35                  40                  45              


Leu Phe Cys Ala Asp Pro Lys Glu Gln Trp Val Lys Asp Ala Met Gln 
    50                  55                  60                  


His Leu Asp Arg Gln Ala Ala Ala Leu Thr Arg Asn Gly Gly Gly Ser 
65                  70                  75                  80  


Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro Leu Glu Thr 
                85                  90                  95      


Phe Thr Arg His Arg Gln Arg Arg Gly Trp Glu Gln Leu Glu Gln Cys 
            100                 105                 110         


Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu 
        115                 120                 125             


Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu Ala Ser Pro 
    130                 135                 140                 


Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln 
145                 150                 155                 160 


Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe Val 
                165                 170                 175     


Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Ser Gly Pro Ala 
            180                 185                 190         


Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu 
        195                 200                 205             


Phe Leu Gly Asp Gly Gly Asp Ile Ser Phe Ser Thr Arg Gly Thr Gln 
    210                 215                 220                 


Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu 
225                 230                 235                 240 


Arg Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala 
                245                 250                 255     


Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp 
            260                 265                 270         


Ala Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr 
        275                 280                 285             


Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg Ile Arg Asn 
    290                 295                 300                 


Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe 
305                 310                 315                 320 


Tyr Arg Thr Gly Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val 
                325                 330                 335     


Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr 
            340                 345                 350         


Gly Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro 
        355                 360                 365             


Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro 
    370                 375                 380                 


Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Lys Glu 
385                 390                 395                 400 


Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro 
                405                 410                 415     


Pro Lys Asp Glu Leu 
            420     


<210>  14
<211>  421
<212>  PRT
<213>  artificial sequence

<220>
<223>  fusion protein SYN016

<400>  14

Met Gln His His Gly Val Thr Lys Cys Asn Ile Thr Cys Ser Lys Met 
1               5                   10                  15      


Thr Ser Lys Ile Pro Val Ala Leu Leu Ile His Tyr Gln Gln Asn Gln 
            20                  25                  30          


Ala Ser Cys Gly Lys Arg Ala Ile Ile Leu Glu Thr Arg Gln His Arg 
        35                  40                  45              


Leu Ala Cys Ala Asp Pro Lys Glu Gln Trp Val Lys Asp Ala Met Gln 
    50                  55                  60                  


His Leu Asp Arg Gln Ala Ala Ala Leu Thr Arg Asn Gly Gly Gly Ser 
65                  70                  75                  80  


Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro Leu Glu Thr 
                85                  90                  95      


Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys 
            100                 105                 110         


Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu 
        115                 120                 125             


Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu Ala Ser Pro 
    130                 135                 140                 


Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln 
145                 150                 155                 160 


Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe Val 
                165                 170                 175     


Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Ser Gly Pro Ala 
            180                 185                 190         


Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu 
        195                 200                 205             


Phe Leu Gly Asp Gly Gly Asp Ile Ser Phe Ser Thr Arg Gly Thr Gln 
    210                 215                 220                 


Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu 
225                 230                 235                 240 


Arg Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala 
                245                 250                 255     


Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp 
            260                 265                 270         


Ala Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr 
        275                 280                 285             


Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg Ile Arg Asn 
    290                 295                 300                 


Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe 
305                 310                 315                 320 


Tyr Arg Thr Gly Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val 
                325                 330                 335     


Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr 
            340                 345                 350         


Gly Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro 
        355                 360                 365             


Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro 
    370                 375                 380                 


Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Lys Glu 
385                 390                 395                 400 


Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro 
                405                 410                 415     


Pro Lys Asp Glu Leu 
            420     


<210>  15
<211>  421
<212>  PRT
<213>  artificial sequence

<220>
<223>  fusion protein SYN017

<400>  15

Met Gln His His Gly Val Thr Lys Cys Asn Ile Thr Cys Ser Lys Met 
1               5                   10                  15      


Thr Ser Lys Ile Pro Val Ala Leu Leu Ile His Tyr Gln Gln Asn Gln 
            20                  25                  30          


Ala Ser Cys Gly Lys Arg Ala Ile Ile Leu Glu Thr Arg Gln His Arg 
        35                  40                  45              


Leu Phe Cys Ala Asp Pro Lys Glu Gln Trp Val Lys Asp Ala Met Gln 
    50                  55                  60                  


His Leu Asp Arg Gln Ala Ala Ala Leu Thr Arg Asn Gly Gly Gly Ser 
65                  70                  75                  80  


Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro Leu Glu Thr 
                85                  90                  95      


Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys 
            100                 105                 110         


Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu 
        115                 120                 125             


Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu Ala Ser Pro 
    130                 135                 140                 


Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln 
145                 150                 155                 160 


Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe Val 
                165                 170                 175     


Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Ser Gly Pro Ala 
            180                 185                 190         


Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu 
        195                 200                 205             


Phe Leu Gly Asp Gly Gly Asp Ile Ser Phe Ser Thr Arg Gly Thr Gln 
    210                 215                 220                 


Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu 
225                 230                 235                 240 


Arg Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala 
                245                 250                 255     


Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp 
            260                 265                 270         


Ala Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr 
        275                 280                 285             


Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg Ile Arg Asn 
    290                 295                 300                 


Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe 
305                 310                 315                 320 


Tyr Arg Thr Gly Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val 
                325                 330                 335     


Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr 
            340                 345                 350         


Gly Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro 
        355                 360                 365             


Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro 
    370                 375                 380                 


Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Lys Glu 
385                 390                 395                 400 


Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro 
                405                 410                 415     


Pro Lys Asp Glu Leu 
            420     


<210>  16
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site


<220>
<221>  PEPTIDE
<222>  (1)..(4)
<223>  cleavage site

<400>  16

Arg Gln Arg Arg 
1               


<210>  17
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site


<220>
<221>  PEPTIDE
<222>  (1)..(4)
<223>  cleavage site

<400>  17

Arg Gln Lys Arg 
1               


<210>  18
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site


<220>
<221>  PEPTIDE
<222>  (1)..(4)
<223>  cleavage site

<400>  18

Arg Ser Lys Arg 
1               


<210>  19
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site


<220>
<221>  PEPTIDE
<222>  (1)..(4)
<223>  cleavage site

<400>  19

Arg Ser Arg Arg 
1               


<210>  20
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site


<220>
<221>  PEPTIDE
<222>  (1)..(4)
<223>  cleavage site

<400>  20

Arg Thr Lys Arg 
1               


<210>  21
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site


<220>
<221>  PEPTIDE
<222>  (1)..(4)
<223>  cleavage site

<400>  21

Arg Thr Arg Arg 
1               


<210>  22
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site


<220>
<221>  PEPTIDE
<222>  (1)..(4)
<223>  cleavage site

<400>  22

Arg Asn Lys Arg 
1               


<210>  23
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site


<220>
<221>  PEPTIDE
<222>  (1)..(4)
<223>  cleavage site

<400>  23

Arg Asn Arg Arg 
1               


