                         SEQUENCE LISTING

<110>  SORRENTO THERAPEUTICS, INC.
       LEVENA (SUZHOU) BIOPHARMA CO., LTD.
       LEVENA BIOPHARMA US, INC.
 
<120>  ANTIBODY-DRUG CONJUGATES COMPRISING AN ANTI-BCMA ANTIBODY

<130>  01223-0089-00PCT

<150>  PCT/CN2021/078886
<151>  2021-03-03

<150>  PCT/CN2021/095379
<151>  2021-05-24

<150>  PCT/CN2022/077512
<151>  2022-02-23

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCA7-2C5 (VL - CDR1)

<400>  1

Thr Gly Thr Ser Ser Ala His Gly Gly His Tyr Tyr Val Ser 
1               5                   10                  


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCA7-2C5 (VL - CDR2)

<400>  2

Asp Val Ser Asn Arg Pro Ser 
1               5           


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCA7-2C5 (VL - CDR3)

<400>  3

Gly Ser Tyr Thr Ser Ser Gly Ser Tyr Val 
1               5                   10  


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCA7-2C5 (VH - CDR1)

<400>  4

Thr Ala Trp Met Ser 
1               5   


<210>  5
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCA7-2C5 (VH - CDR2)

<400>  5

Arg Ile Lys Ser Lys Ser Asp Gly Gly Thr Thr Asp Tyr Ala Ala Pro 
1               5                   10                  15      


Val Lys Gly 
            


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCA7-2C5 (VH - CDR3)

<400>  6

Ala Lys Gly Gly Gly Thr Tyr Gly Tyr 
1               5                   


<210>  7
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCA7-2C5 light chain variable sequence

<400>  7

Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Ala His Gly Gly His 
            20                  25                  30          


Tyr Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Thr Ser Ser 
                85                  90                  95      


Gly Ser Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  8
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCA7-2C5 heavy chain variable sequence; BCA7-2E1 heavy chain 
       variable sequence

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Ser Thr Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Ser Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Phe Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Lys Gly Gly Gly Thr Tyr Gly Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  9
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCA7-2E1 (VL - CDR1)

<400>  9

Thr Gly Thr Ser Ser Asp Gly Gly Gly His Thr Tyr Val Ser 
1               5                   10                  


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCA7-2E1 (VL - CDR2)

<400>  10

Asp Val Ser Asn Arg Pro Ser 
1               5           


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCA7-2E1 (VL - CDR3)

<400>  11

Gly Ser Tyr Thr Ser Ser Gly Ser Tyr Val 
1               5                   10  


<210>  12
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCA7-2E1 (VH - CDR1)

<400>  12

Thr Ala Trp Met Ser 
1               5   


<210>  13
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCA7-2E1 (VH - CDR2)

<400>  13

Arg Ile Lys Ser Lys Ser Asp Gly Gly Thr Thr Asp Tyr Ala Ala Pro 
1               5                   10                  15      


Val Lys Gly 
            


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCA7-2E1 (VH - CDR3)

<400>  14

Ala Lys Gly Gly Gly Thr Tyr Gly Tyr 
1               5                   


<210>  15
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCA7-2E1 light chain variable sequence

<400>  15

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Gly Gly Gly His 
            20                  25                  30          


Thr Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Trp Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Thr Ser Ser 
                85                  90                  95      


Gly Ser Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  16
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              


Val Lys Gly Thr Asn Ala Ile Leu Trp Thr Cys Leu Gly Leu Ser Leu 
    50                  55                  60                  


Ile Ile Ser Leu Ala Val Phe Val Leu Met Phe Leu Leu Arg Lys Ile 
65                  70                  75                  80  


Asn Ser Glu Pro Leu Lys Asp Glu Phe Lys Asn Thr Gly Ser Gly Leu 
                85                  90                  95      


Leu Gly Met Ala Asn Ile Asp Leu Glu Lys Ser Arg Thr Gly Asp Glu 
            100                 105                 110         


Ile Ile Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys 
        115                 120                 125             


Glu Asp Cys Ile Lys Ser Lys Pro Lys Val Asp Ser Asp His Cys Phe 
    130                 135                 140                 


Pro Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr Thr Lys 
145                 150                 155                 160 


Thr Asn Asp Tyr Cys Lys Ser Leu Pro Ala Ala Leu Ser Ala Thr Glu 
                165                 170                 175     


Ile Glu Lys Ser Ile Ser Ala Arg 
            180                 


